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29,500
Percutaneous venous thrombectomy using the Arrow-Trerotola percutaneous thrombolytic device (PTD) with temporary caval filtration: in vitro investigations.
To evaluate the size and quantity of downstream emboli after thrombectomy using the Arrow-Trerotola Percutaneous Thrombolytic Device (PTD) with or without temporary filtration for extensive iliofemoral and iliocaval thrombi in an in vitro flow model.</AbstractText>Iliocaval thrombi were simulated by clotted bovine bloo...
29,501
Endothelial progenitor cells are recruited into resolving venous thrombi.
The purpose of this study was to determine whether endothelial cells of bone marrow origin are involved in thrombus recanalization.</AbstractText>Irradiated mice were reconstituted with bone marrow from transgenic donors expressing green fluorescent protein (GFP) linked to the Tie2 promoter. Thrombi were formed in 2 gr...
29,502
Improving the evidence base for promoting quality and equity of surgical care using population-based linkage of administrative health records.
This paper highlights the uses of population-based linkage of administrative health records to improve the quality, safety, and equity of surgical care. The primary focus of the paper is on the transfer of this type of research into policy and practice. In the modern era of evidence-based medicine, it is essential that...
29,503
Coronary heart disease in menopausal women: implications of primary and secondary prevention trials of hormones.
In direct contrast to the observational studies, both primary and secondary prevention trials of female reproductive hormones have found no benefit for coronary heart disease (CHD). Basic science studies have elucidated several mechanisms by which estrogen may improve coronary arterial physiology and prevent pathology,...
29,504
An adult case of moyamoya syndrome that developed dural sinus thrombosis associated with protein C deficiency: case report and literature review.
We describe a 54-year-old woman exhibiting MMS who developed delayed dural sinus thrombosis associated with PCD. Angiographic findings of the patient were so unusual that bilateral internal carotid arteries were occluded between their origin and the carotid fork with extensive development of collateral circulation via ...
29,505
Clear-cell cancer of the ovary-is it chemosensitive?
The records of all patients with clear-cell ovarian cancer (CCC) who underwent complete surgical staging and chemotherapy between 1984 and 2001 were reviewed and 39 patients identified as suitable for study. The mean patient age was 56 years, and the stage distribution was as follows: stage I, 53%; stage II, 13%; stage...
29,506
[Surgical aspects in the third and fourth kidney retransplant].
A quarter of patients waiting for kidney transplantation are patients with previous graft failure. Outcome of first and second renal transplant make these the gold standard for end renal stage disease, but this is not so clear in the case of third and further renal transplant, especially at the time of organ shortage. ...
29,507
[Management of complications of hemodialysis vascular accesses].
Trombosis of the vascular access is the most frecuent complication among patients with chronic renal disease. From 1995 on we performed the percutaneous recanalization of the access and considered the procedure as the best option. We analized the results in the two groups of patients treated at different periods and em...
29,508
Salvage of free second toe with venous thrombosis by shunting retrograde arterial flow of second dorsal metatarsal artery.
Although there are case reports about salvaging amputated digits without venous return by shunting retrograde blood flow from a distal digital artery to a proximal vein (Smith et al., Plast Reconstr Surg 71:52, 1983), successful salvage of a congested free toe with efferent arteriovenous (AV) shunting retrograde arteri...
29,509
A technique for retroperitoneal pancreas transplantation with portal-enteric drainage.
Pancreas transplantation (PTx) with portal-enteric drainage (PED) has been associated with difficulties in respect to arterial anastomosis and graft accessibility for percutaneous biopsy. We describe a new technique that circumvents these difficulties.</AbstractText>Between April 2001 and April 2004, a total of 113 rec...
29,510
Laparoscopic radical cystectomy in the female.
We detail the technique of completely intracorporeal laparoscopic radical cystectomy in the female patient, which has previously not been well described in the literature. Additionally, perioperative and short-term oncological outcome data are presented.</AbstractText>Since 2000, 11 female patients underwent laparoscop...
29,511
Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction.
Cerebral venous ischemia often induces severe brain edema. Vascular endothelial growth factor (VEGF), which induces angiogenesis, is also known as vascular permeability (VP) factor. The present study was undertaken to investigate whether the inhibition of VEGF could reduce brain edema formation and cerebral venous infa...
29,512
Improved quality of stroke care for hospitalized Medicare beneficiaries in Michigan.
We reported previously that acute ischemic stroke patients encountered delays in obtaining neuroimaging and receiving thrombolysis, and that deep venous thrombosis prophylaxis was used only in a minority of eligible patients. We investigated whether these and other measures improved after a quality improvement initiati...
29,513
Long-term treatment of deep venous thrombosis with a low molecular weight heparin (tinzaparin): a prospective randomized trial.
Evaluation of the effectiveness and safety of the low molecular weight heparin (LMWH) tinzaparin versus unfractionated heparin (UFH) followed by acenocoumarol in proximal deep venous thrombosis (DVT).</AbstractText>Prospective, randomized clinical trial.</AbstractText>Consecutive patients (n=108) with acute leg DVT, co...
29,514
Different antithrombotic properties of factor Xa inhibitor and thrombin inhibitor in rat thrombosis models.
We compared the antithrombotic properties of a factor Xa inhibitor (DX-9065a) with those of a thrombin inhibitor (melagatran) in a rat disseminated intravascular coagulation model and a rat venous thrombosis model. Rat disseminated intravascular coagulation and venous thrombosis models were produced by injection of tis...
29,515
[Mondor's disease: about two cases].
The authors report two cases of Mondor's disease after mammoplasty reduction's surgery. This pathology rare and benign should be known by all surgeons, because it could be a postoperative discord, especially in these lithigious times. If the evolution is favourable in one or two months, the therapeutic urgency is to re...
29,516
Relevance of the criteria commonly used to diagnose myeloproliferative disorder in patients with splanchnic vein thrombosis.
Myeloproliferative disorders (MPD) are reported in 25-65% of patients with splanchnic vein thrombosis (SVT). Diagnostic criteria for MPD have not been fully established in this context. Using clusters of abnormal megakaryocytes in bone marrow (BM) biopsy as a reference standard for Philadelphia negative MPD, we assesse...
29,517
Economic and utilization outcomes associated with choice of treatment for venous thromboembolism in hospitalized patients.
Hospital administrative data were analyzed to assess treatment patterns, in-hospital mortality, rates of hemorrhagic events and thrombus propagation, utilization of health care resources, and hospital costs associated with various treatments during inpatient care for venous thromboembolism (VTE).</AbstractText>Data fro...
29,518
A false aneurysm mistaken for a DVT after hip surgery.
False or pseudoaneurysm formation usually occurs after traumatic, iatrogenic or infective injury to the arterial wall. Despite the high incidence of pseudoaneurysm formation secondary to puncture injury to the common femoral artery false aneurysm formation of the profunda femoris artery (PFA) is a rare complication and...
29,519
Pharmacodynamic effects of low molecular weight heparin in obese subjects following subcutaneous administration of 75 IU/kg on plasma tissue factor pathway inhibitor and nitric oxide.
Pharmacodynamic effects of the low molecular weight heparin tinzaparin on plasma levels of tissue factor pathway inhibitor (TFPI) and nitric oxide (NO) were compared in obese subjects, as well as in normal healthy controls.</AbstractText>Obese (n = 13) patients received a single 75 IU/kg SC injection (the deep vein thr...
29,520
A critical appraisal of non-invasive diagnosis and exclusion of deep vein thrombosis and pulmonary embolism in outpatients with suspected deep vein thrombosis or pulmonary embolism: how many tests do we need?
The requirement for a safe diagnostic strategy should be based on an overall posttest incidence of venous thromboembolism of less than 1% during 3 month follow-up. Compression ultrasonography (CUS) has a negative predictive value (NPV) of 97% to 98% indicating the need of repeated CUS testing. Serial CUS testing is saf...
29,521
Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence.
Thrombophilia is the term now used to describe predisposition to increased risk of venous and occasionally arterial thromboembolism due to hematological abnormalities. It can be a multifactorial disorder where congenital defects of anticoagulant or procoagulant factors may be combined with acquired hematological abnorm...
29,522
Slow continuous intravenous plasmapheresis (SCIP): clinical applications and hemostability of extracorporeal ultrafiltration.
An intravenous plasmapheresis catheter which excludes &gt;99.4% of platelets from external ultrafiltration circuits is currently undergoing safety and efficacy trials for fluid removal from NYHA class II-IV congestive heart failure patients resistant to diuretic drug therapy. In animals, the SCIP catheter allowed a fou...
29,523
Should nephrologists be in charge?
Once, vascular access (VA) for hemodialysis treatment was initiated by nephrologists: Scribner introduced the arteriovenous shunt, Shaldon the central-venous catheters and Brescia-Cimino the arteriovenous fistula. Later on, creating VA became a domain of surgery. Many nephrologists felt out of responsibility. Intervent...
29,524
Pulmonary embolism in a patient with severe congenital deficiency for factor V during treatment with fresh frozen plasma.
Thrombosis is a rare complication in patients with congenital clotting factor deficiencies. In most cases, it is related to inherited procoagulant factors, use of central venous catheters or administration of coagulation factor concentrates. There are only a few case reports about thrombotic events during treatment wit...
29,525
Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits.<Pagination><StartPage>515</StartPage><EndPage>521</EndPage><MedlinePgn>515-21</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Vein graft stenosis is a common ...
Thromboembolic complications, frequently associated with idiopathic membranous glomerulonephritis, are frequent and serious problems associated with nephrotic syndrome. However, ovarian vein thrombosis associated with nephrotic syndrome has never been reported. This study describes the case of a 35-year-old woman with ...
29,526
[Cavernous transformation of portal vein].
Cavernous transformation of the portal vein occurs with long-standing portal vein thrombosis (PVT) because of the development and dilatation of multiple small vessels in and around the recanalising main portal vein. Thrombosis and occlusion of the portal vein leads to portal hypertension with enlarged spleen and the de...
29,527
Heparin-induced cardiac tamponade and life-threatening hyperkalema in a patient with chronic hemodialysis.
Heparin, a commonly used anticoagulant agent, is frequently used in patients undergoing hemodialysis. As with most medications, heparin has a significant side effect profile. Two of its most important side effects, major bleeding and hyperkalemia, may be devastating without immediate diagnosis and treatment. Major blee...
29,528
Anastrozole: new indication. Adjuvant treatment of non metastatic breast cancer: useful for some patients.
(1) For postmenopausal women with hormone-receptor-positive breast cancer, the reference adjuvant treatment after surgical excision is tamoxifen (an anti-estrogen), taken orally at a dose of 20 mg/day for 5 years. (2) Anastrozole is the first aromatase inhibitor to be licensed for this use in France. (3) Marketing auth...
29,529
Experience of temporary inferior vena cava filters inserted in the perinatal period to prevent pulmonary embolism in pregnant women with deep vein thrombosis.
We placed temporary inferior vena cava filters to prevent pulmonary thromboembolism in patients with deep vein thrombosis (DVT) who were presumed to have an increased risk of pulmonary embolism in the perinatal period. These experiences of using temporary inferior vena cava filters in pregnant women are reported.</Abst...
29,530
Transcatheter thrombolytic therapy for acute mesenteric and portal vein thrombosis.
The purpose of this study was to evaluate the utility of transcatheter thrombolytic therapy in 20 patients with acute or subacute (symptoms &lt;40 days) portal and/or mesenteric vein thrombosis with severe symptoms, deteriorating clinical condition, and/or persistent symptoms despite anticoagulation.</AbstractText>This...
29,531
Management of suspected venous thromboembolism: the impact of a multifaceted intervention.
To achieve a common strategy in the event of a suspected venous thromboembolism.</AbstractText>A multifaceted intervention, combining an audit strategy and implementation of local guidelines: phase 1, the first step, consisted of a 6-month audit to identify dysfunction; during phase 2, intervention, local guidelines we...
29,532
Hyperhomocysteinemia and venous thrombosis.
Deep vein thrombosis (DVT) leads to venous ulcers in later life. Venous ulcers are the majority of chronic lower extremity wounds. Recent evidence suggests that hyperhomocysteinemia is an independent risk factor for venous thrombosis. Other evidence suggests that dietary supplementation with folic acids and vitamins he...
29,533
[Neurological manifestations of the antiphospholipid syndrome].
Antiphospholipid syndrome can be associated with several neurological manifestations. The most common symptom is headache. It has also been associated with cognitive dysfunction, probably due to ischemia. A high prevalence of antiphospholipid antibodies has been found in patients with epilepsy and in transverse myeliti...
29,534
[Iliofemoral and iliocaval interventions in deep venous thrombosis].
Significant spontaneous thrombus disintegration in deep venous thrombosis (DVT) occurs very infrequently. On the contrary, these thrombi are prone to appositional growth and migration into the pulmonary arteries. The development of chronic venous insufficiency due to postthrombotic syndrome is a frequent consequence of...
29,535
[Sinus and venous thrombosis--differential diagnosis of acute stroke].
Thrombosis of the cerebral veins and sinus is a rare, but important cause of stroke. The clinical picture varies. This contribution addresses the etiology, clinical picture, imaging procedures, and therapeutic options.
29,536
Survival rate in patients with hepatocellular carcinoma: a retrospective analysis of 389 patients.
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. However, treatment options are limited and often inefficient. The aim of this study was to determine current survival rates for patients diagnosed with HCC and to identify prognostic factors, which will help in choosing optimal therapies for indi...
29,537
Homozygous factor V Leiden mutation in two siblings presenting with acute myocardial infarction: a rare cause of myocardial infarction in the young.
Although factor V Leiden mutation, is the most common established genetic risk factor for venous thrombosis, its effect on the development of myocardial infarction remains unclear. We describe a family case of homozygous factor V Leiden mutation in two siblings presenting with acute myocardial infarction as a rare caus...
29,538
von Willebrand factor multimer composition is modified following oral methionine load in women with thrombosis, but not in healthy women.
Hyperhomocysteinemia is associated with an increased risk of venous and arterial thrombosis, probably by inducing endothelial damage. Von Willebrand factor (VWF) is an endothelial marker protein. It is a plasma multimeric molecule that plays a thrombophilic role. Our purpose was to investigate VWF changes in patients w...
29,539
The effects of ximelagatran and warfarin on the prophylaxis of a caval vein thrombosis and bleeding in the anaesthetized rat.
The antithrombotic and bleeding properties of the oral direct thrombin inhibitor ximelagatran and of warfarin were investigated in an experimental venous thrombosis and bleeding model in anaesthetized rats. Rats were randomized to receive ximelagatran (1-20 micromol/kg), warfarin (0.20-0.82 micromol/kg), or vehicle (ta...
29,540
Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement.
Recombinant human soluble thrombomodulin (ART-123) is composed of the active, extracellular, domain of thrombomodulin. ART-123 binds to thrombin and this complex converts protein C into the natural anticoagulant activated protein C. This study was performed to identify an effective and safe dose of ART-123 for preventi...
29,541
Poor anticoagulation quality in the first 3 months after unprovoked venous thromboembolism is a risk factor for long-term recurrence.
Several factors are associated with an increased risk of recurrent venous thromboembolism (VTE). The aim of the study was to investigate whether the quality of oral anticoagulation therapy (OAT) is a long-term risk factor for recurrence of VTE after OAT interruption.</AbstractText>A total of 297 patients (170 males) wi...
29,542
Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis.
Limited data exist on the risk of pregnancy-associated venous thromboembolism (VTE) in women with a history of VTE.</AbstractText>To evaluate the risk of recurrent pregnancy-associated thrombosis in women with previous VTE in a large retrospective cohort study.</AbstractText>One hundred and fifty-nine women with at lea...
29,543
Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study.
Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT.</AbstractText>We prospectively studied postmenopausal women with suspected DVT in whom HRT use status was ...
29,544
Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome.
About 30% of patients with an episode of adequately treated deep venous thrombosis (DVT) develop the postthrombotic syndrome (PTS) within 2 years. During treatment with vitamin K antagonists (VKA) patients spend only 60% of time between an International Normalized Ratio (INR) of 2.0 and 3.0. We hypothesized that patien...
29,545
Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide.
Oral contraceptive (OC) use increases venous thrombosis (VTE) risk and causes activated protein C (APC) resistance. Plasma glucosylceramide (GlcCer) deficiency is associated with VTE and GlcCer functions as an APC anticoagulant cofactor. Because estradiol decreases GlcCer in cultured cells, we hypothesized OC use would...
29,546
Safety, pharmacokinetics, and immunogenicity of single-dose rFXIII administration to healthy volunteers.
Factor XIII (FXIII) is a transglutaminase that cross-links fibrin and other proteins to improve clot strength and resistance to fibrinolysis. Both congenital and acquired FXIII deficiency may result in a bleeding diathesis, and plasma-derived FXIII has been used to treat many of these clinical conditions.</AbstractText...
29,547
The influence of extreme body weight on clinical outcome of patients with venous thromboembolism: findings from a prospective registry (RIETE).
Data evaluating the safety of using weight-based dosing of low-molecular-weight heparin (LMWH) in either underweight or obese patients with venous thromboembolism (VTE) are limited. Thus, recommendations based on evidence from clinical trials might not be suitable for patients with extreme body weight.</AbstractText>Pa...
29,548
Is chronic HIV infection associated with venous thrombotic disease? A systematic review.
Infection with the human immunodeficiency virus (HIV) is still a major health problem world-wide. HIV infection has changed into a chronic infection with the chance of developing long-term complications. Vascular complications are frequently reported in the current literature. HIV and treatment by highly active antiret...
29,549
Mathematical model for pressure losses in the hemodialysis graft vascular circuit.
Stenosis-induced thrombosis and abandonment of the hemodialysis synthetic graft is an important cause of morbidity and mortality. The graft vascular circuit is a unique low-resistance shunt that has not yet been systematically evaluated. In this study, we developed a mathematical model of this circuit. Pressure losses ...
29,550
Pulmonary embolism: which pediatric trauma patients are at risk?
<AbstractText Label="BACKGROUND/PURPOSE" NlmCategory="OBJECTIVE">Deep vein thrombosis and pulmonary embolism (DVT/PE) are rare in pediatric trauma patients, and guidelines for prophylaxis are scarce. The authors sought to identify subgroups of patients who may be at higher risk of developing DVT/PE.</AbstractText>Case-...
29,551
Evaluation of renal grafts in patients with lupus nephritis as cause of end-stage renal disease.
Kidney transplantation is the best option in end-stage renal disease (ESRD). For many years patients affected with lupus nephritis have had poor graft results. However, this has been changing over recent years with the development of new immunosuppressive drugs and a better comprehension of the natural evolution of the...
29,552
Cost-effectiveness of prophylactic low molecular weight heparin in pregnant women with a prior history of venous thromboembolism.
Women with a history of prior venous thromboembolism have an increased risk for recurrence during pregnancy. Although thromboprophylaxis reduces this risk, recent evidence suggests that, in many cases, prophylaxis can be safely withheld because the estimated recurrence risk is very low. The balance of risks and benefit...
29,553
Quantitative assessment of thrombus burden predicts the outcome of treatment for venous thrombosis: a systematic review.
Clot-burden change in patients receiving anticoagulant therapy, by predicting subsequent recurrent venous thromboembolism, may provide a clinically relevant surrogate endpoint of prognostic importance. The validity of this objective measure is yet to be established.</AbstractText>A PubMed search was performed to retrie...
29,554
Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals.<Pagination><StartPage>133</StartPage><EndPage>137</EndPage><MedlinePgn>133-7</MedlinePgn></Pagination><Abstract><AbstractText>Diabetes mellitus (DM) is complicated by vascular and neurological events. Antipho...
Diabetes mellitus (DM) is complicated by vascular and neurological events. Antiphospholipid (aPL) antibodies have already been associated with many clinical conditions, including venous and arterial thrombosis, as well as recurrent fetal loss. However, a significant association between aPL antibodies and DM has not bee...
29,555
Venous thromboembolism: diagnosis and management of deep venous thrombosis.
Venous thromboembolism (VTE) affects 1-2 per 1000 people in the general population each year. Clinical diagnosis of deep venous thrombosis (DVT) is unreliable, and must be confirmed by compression ultrasonography or venography. A low clinical pretest probability of DVT and negative D-dimer result reliably exclude the d...
29,556
[Isolated splenic vein thrombosis].
We report the case of 61-year-old woman with isolated splenic vein thrombosis resulted from chronic pancreatitis. Left-sided portal hypertension secondary to splenic vein occlusion was responsible for development of the isolated gastric varices. The patient underwent prophylactic, successful splenectomy. Three months a...
29,557
Occupational relevance of subclavian vein thrombosis in association with thoracic outlet syndrome.
Primary subclavian vein thrombosis ("effort thrombosis") is not generally recognized as a work-related disorder, and more knowledge is required on the particular biomechanical risks. An extensive biomechanical risk analysis was performed for a possible work-related case.</AbstractText>A hard-working 43-year-old race-co...
29,558
Hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome.
To report a case of hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome.</AbstractText>Interventional case report: a 49-year-old woman with a history of systemic lupus erythematosus and antiphospholipid antibody syndrome presented with sudden onset of pain, redness, phot...
29,559
The prophylactic use of inferior vena cava filters in patients undergoing high-risk spinal surgery.
Prophylactic inferior vena cava filter (IVCF) placement is advocated in some high-risk groups. We sought data regarding safety and efficacy for prophylactic IVCF placement in patients at high risk for venous thromboembolism (VTE) following major spinal reconstruction. Seventy-four spine surgery patients with contraindi...
29,560
Surrogate end points in clinical research: hazardous to your health.
Surrogate end points in clinical research pose real danger. A surrogate end point is an outcome measure, commonly a laboratory test, that substitutes for a clinical event of true importance. Resistance to activated protein C, for example, has been used as a surrogate for venous thrombosis in women using oral contracept...
29,561
Low-molecular-weight heparin (dalteparin) in women with gynecologic malignancy.
To compare the efficacy of dalteparin, a low-molecular-weight heparin, to unfractionated heparin (UFH) in the prevention of deep venous thrombosis (DVT) and pulmonary embolism in patients after surgery for gynecologic malignancy.</AbstractText>The medical records of all patients undergoing major surgery on the Gynecolo...
29,562
Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism.
The purpose of this research was to determine the levels of platelet, leukocyte, and endothelial activation and markers of cellular interactions in patients with venous thromboembolism (VTE).</AbstractText>The details of interactions between endothelium, platelets, and leukocytes in VTE are not well understood.</Abstra...
29,563
Right portal vein thrombosis after splenectomy for trauma.
Portal vein thrombosis may complicate splenectomy in patients with hemolytic anemia and myeloproliferative disease, whereas the frequency of portal vein thrombosis in case of trauma is not defined. A case of right portal vein thrombosis after splenectomy for trauma is reported in this paper. Hematologic workup did not ...
29,564
Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study.
Temozolomide plus thalidomide is a promising oral combination regimen for the treatment of metastatic melanoma. The current Phase II study examined the efficacy and safety of this combination in chemotherapy-naive patients with brain metastases.</AbstractText>Patients with histologically confirmed metastatic melanoma a...
29,565
Arterial blood flow changes after free tissue transfer in head and neck reconstruction.
The authors measured pedicle arterial flow volume output using color Doppler ultrasonography in 23 patients after free tissue transfer in head and neck reconstruction.</AbstractText>Transferred flaps included six free jejunums, eight free radial forearm flaps, and four anterolateral thigh flaps. Flow volume output coul...
29,566
Central venous lines in children with lesser risk acute lymphoblastic leukemia: optimal type and timing of placement.
In pediatric patients with acute lymphoblastic leukemia (ALL), the optimal time for central venous line (CVL) insertion and the optimal type of CVL (internal v external) is unclear. This study was undertaken to compare complication rates between early versus late line insertion, and between internal versus external lin...
29,567
Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition.
The protein C system provides important control of blood coagulation by regulating the activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively. The system comprises membrane-bound and circulating proteins that assemble into multi-molecular complexes...
29,568
Cerebral MR venography in children: comparison of 2D time-of-flight and gadolinium-enhanced 3D gradient-echo techniques.
To prospectively compare two-dimensional (2D) time-of-flight cerebral magnetic resonance (MR) venography with gadolinium-enhanced three-dimensional (3D) gradient-echo cerebral MR venography in children.</AbstractText>This investigation had investigational review board approval and was Health Insurance Portability and A...
29,569
Normal retinal vasculature despite familial protein C deficiency.
It is unclear whether protein C deficiency is associated with retinal venous occlusive disease.</AbstractText>We performed a cross-sectional study.</AbstractText>Members of a protein C-deficient family, either deficient or nondeficient, with a history of nonocular venous thrombosis were included. All participants compl...
29,570
Extensive upper-extremity venous thrombosis after fluorescein angiography.
To report a case of extensive cephalic and basilic venous thrombosis after fluorescein angiography.</AbstractText>Interventional case report.</AbstractText>A 38-year-old Chinese male presented with blurring of vision in his left eye. Clinical examination revealed central serous retinopathy, and a routine fluorescein an...
29,571
Central retinal vein occlusion with further reduction of retinal blood flow one year after radial optic neurotomy.
To report a case of central retinal vein occlusion (CRVO) that had vitrectomy with radial optic neurotomy (RON), but the retinal blood flow (RBF) was still reduced 1 year later.</AbstractText>Interventional case report.</AbstractText>An 80-year-old woman had undergone vitrectomy and RON for a CRVO. She had a complete o...
29,572
Intravitreal triamcinolone acetonide for cystoid macular edema in nonischemic central retinal vein occlusion.
The effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema from central retinal vein occlusion (CRVO) was investigated.</AbstractText>A noncomparative, prospective, interventional case series.</AbstractText>In a clinical practice, 18 patients were enrolled with nonischemic CRVO ...
29,573
A catastrophic case of skin gangrene.
We describe the case of a 70-year-old male with the catastrophic antiphospholipid syndrome admitted for skin gangrene of the fingers. The initial diagnosis was antiphospholipid antibody syndrome in a patient with rheumatoid arthritis and a history of deep vein thrombosis of the lower limbs. Liver involvement, the chara...
29,574
Clinics in diagnostic imaging (103). Dural sinus thrombosis with cerebral venous infarction.
A 13-year-old boy had a history of severe headache for two weeks. He also had seizures and vomited many times. Neurological examination was normal except for bilateral papilloedema. Sagittal T1-weighted magnetic resonance (MR) images showed loss of the normal flow void in the superior sagittal sinus. There was hyperint...
29,575
[Pulmonary lesions and total parenteral nutrition in children admitted to a pediatric intensive care unit].
To describe lung injuries in autopsied pediatric patients (neonates through 15 years old) subjected or not to total parenteral nutrition, in an intensive care unit.</AbstractText>Sections from six paraffin-embedded lung fragments, from 114 children were studied by routine staining. Demographic, clinical and therapeutic...
29,576
Central venous catheter use in the pediatric patient: mechanical and infectious complications.
Following the introduction and widespread use of central venous catheters (CVCs) in adults, these devices are being used with increasing frequency in the pediatric population. This review will focus on differences between adults and children regarding CVC use and its potential complications. Both mechanical and infecti...
29,577
Venous thromboembolism in the medically ill patient: a call to action.
The risk of venous thromboembolism (VTE) in medical patients is generally underestimated. However, recent studies including two large double-blind placebo-controlled trials, the Prospective Evaluation of Dalteparin Efficacy for Prevention of VTE in Immobilised Patients trial (PREVENT) and prophylaxis in MEDical patient...
29,578
Mondor's disease of the breast: is there any relation to breast cancer?
Ten cases of Mondor's disease of the breast (9 females, 1 male) are described. The diagnosis was based mainly on clinical examination, while breast imaging, used in five cases, was complementary. Most of our cases (9) had complete restoration of the thrombosed subcutaneous breast vein, either spontaneously (4), or afte...
29,579
[Complications of central venous access devices: outcome analysis of 2359 implantations].
The implantation of venous access devices is of great importance in the treatment of oncological patients. Such systems allow a safe application of highly efficacious drugs with great comfort for the patient. Knowing the rate of complications, is wide indication for such implantations justified?</AbstractText>From July...
29,580
Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study.
Current methods of posttraumatic thromboprophylaxis (heparins and sequential compression devices) are inadequate. New methods should be tested. Muscle electrostimulation (MEST) has been used over the years with mixed-but predominantly encouraging-results for a variety of conditions, including prevention of deep venous ...
29,581
Nontraumatic chest wall systemic-to-pulmonary artery fistula.
A congenital chest wall systemic-to-left pulmonary artery fistula fed by the left internal mammary and left gastric arteries in a 31-year-old man is reported. Attempted sclerosis was complicated by rupture of the communicating vessel, hemothorax, and deep vein thrombosis of the legs. Fistula resection and pulmonary dec...
29,582
[Portal vein involvement by hepatocellular carcinoma: diagnosis with three-dimensional contrast-enhanced MR angiography].
To assess the accuracy of three-dimensional contrast-enhanced magnetic resonance angiography (3D CE MRA) in evaluating the portal vein involvement in patients with hepatocellular carcinoma.</AbstractText>Ninety patients with hepatocellular carcinoma underwent 3D CE MRA of the portal venous system, using a high-field 1....
29,583
[Budd-Chiari syndrome with occlusion of hepatic vein: multi-slice spiral CT diagnosis and its clinical significance in the treatment].
To evaluate the multi-slice spiral CT dynamic enhancement features and the diagnostic value of CT angiography in Budd-Chiari syndrome with occlusion of hepatic vein (HVBCS), and to assess the CT clinical significance in the treatment of HVBCS.</AbstractText>Twenty-one patients with HVBCS confirmed by digital subtractio...
29,584
[Application of percutaneous transluminal angioplasty and stent placement at the third hepatic porta in treatment of Budd-Chiari syndrome].
To evaluate percutaneous transluminal angioplasty (PTA) and stent placement at the third hepatic porta in treatment of Budd-Chiari syndrome (BCS).</AbstractText>Twenty patients with BCS, 12 males and 8 females, aged 17 to 53, with the main clinical symptom of abdominal distention and mild abdominal pain, were treated w...
29,585
[Latest cognition of treatment on deep vein thrombosis of lower extremity].
To explore the effects of surgical procedure combined with the intravascular minimal invasive technique for the treatment of deep vein thrombosis (DVT) of lower extremity.</AbstractText>At the curse of disease from six hours to ninety days, one hundred and two patients with DVT including one hundred and three lower ext...
29,586
Survival and complications of indwelling venous catheters for permanent use in hemodialysis patients.
The risk factors influencing the survival of indwelling central vein catheters and their potential complications have not been assessed in depth and on a large scale.</AbstractText>We investigated the general characteristics of 245 single lumen cuffed tunneled catheters and analyzed their survival by Kaplan-Meier and C...
29,587
Lipoprotein(a) levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage.
The aim of the study was to compare lipoprotein(a) [Lp(a)] levels in patients with cTroponin-I (cTn-I)-positive or -negative unstable angina and to investigate their relationship with atherothrombosis. A total of 202 consecutive patients were enrolled in the study. Lp(a), fibrinogen, plasminogen, PAI-1 and t-PA levels ...
29,588
Symptomatic portal system thrombosis in soldiers due to extended stay at extreme altitude.
With induction of Indian Army to heights over 5000 m above mean sealevel (MSL), several new complications of long-term stay at extreme altitude have come to light. The authors' experience with soldiers who developed symptomatic portal system thrombosis (SPST) is described here.</AbstractText>Clinical data were prospect...
29,589
Cost considerations surrounding current and future anticoagulant therapies.
Because the costs of anticoagulation therapy are substantial and the difference between the risks and benefits of this therapy are often narrow, economic analyses are particularly valuable when weighing anticoagulation options. Economic analyses to date suggest that anticoagulation is most effective and results in the ...
29,590
Anticoagulation in special patient populations: are special dosing considerations required?
Optimal dosing of low-molecular-weight heparin (LMWH) therapy has not yet been established for patients with morbid obesity or renal insufficiency or for pregnant women. Monitoring of anti-Xa levels appears to be helpful in guiding LMWH dosing in all of these patient groups. Use of fondaparinux in these populations has...
29,591
Current and emerging options in the management of venous thromboembolism.
Venous thromboembolism (VTE) is a common disease whose diagnosis is challenging. The best diagnostic approaches combine the patient's pretest clinical probability of disease with D-dimer testing and/or diagnostic imaging. In light of several advantages, low-molecular-weight heparins are now recommended over unfractiona...
29,592
Prevention of venous thromboembolism in medical and surgical patients.
Prophylaxis against venous thromboembolism (VTE) should be considered in all hospitalized patients, as VTE is a significant cause of morbidity and mortality in the hospital. Although VTE risk is greatest and VTE prophylaxis is more established in surgical patients, most hospitalized medical patients have one or more ri...
29,593
Deep vein thrombosis (DVT) in advanced cancer patients with lower extremity edema referred for assessment.
Lower extremity edema is a common complication in advanced cancer patients, and deep vein thrombosis (DVT) is one among many causes. Clinical signs and symptoms are known to be unreliable, and radiographic investigations are often required in diagnosing DVT. A retrospective chart review was conducted on 46 advanced can...
29,594
[Critical incidents during regional anesthesia in Japanese Society of Anesthesiologists-Certified Training Hospitals: an analysis of responses to the annual survey conducted between 1999 and 2002 by the Japanese Society of Anesthesiologists].
Recently, a national survey in France including 35,439 patients who had received spinal anesthesia showed that the incidences of cardiac arrest and mortality associated with spinal anesthesia were 2.5 and 0.8 per 10,000 anesthetics, respectively. In this study, we investigated these values using data obtained from annu...
29,595
Preoperative vascular imaging in pediatric liver transplantation.
<AbstractText Label="BACKGROUND/PURPOSE" NlmCategory="OBJECTIVE">There is a considerable variation in the use of vascular imaging techniques in the preoperative assessment of children scheduled for liver transplantation. Duplex Doppler ultrasound scan (US), magnetic resonance angiography (MRA), and conventional angiogr...
29,596
Lower doses of oral estrogen and progestogens as treatment for postmenopausal women.
Estrogen, with or without a progestin, is effective for the treatment of menopausal symptoms. Larger doses of estrogen/progestin have been used than required for the amelioration of menopausal symptoms. Both positive and negative outcomes of hormone therapy are reported in postmenopausal women. The positive aspects hav...
29,597
Prognostic implications of warfarin cessation after major trauma: a population-based cohort analysis.
Warfarin therapy is often withheld from elderly patients who fall or otherwise experience injury because of concerns regarding the long-term risk of hemorrhage in these individuals. We studied whether stopping warfarin after trauma is associated with a higher risk of subsequent adverse cardiovascular events.</AbstractT...
29,598
Experimental percutaneous cannulation of the supraorbital arteries: implication for future therapy.
There is some evidence to suggest that thrombolysis has a beneficial effect in retinal vessel occlusion. However, there is concern that this therapeutic approach carries the risk of hemorrhage. Retrograde cannulation of the supraorbital arteries followed by irrigation with fibrinolytic agents may have the potential to ...
29,599
Venous thromboembolic disease prophylaxis among general surgeons in Malaysia.
The aim of this study was to analyse the current practice of venous thromboembolism (VTE) prophylaxis among general surgeons in Malaysia.</AbstractText>A questionnaire survey was conducted among general surgeons attending the annual Malaysian College of Surgeons meeting in 2002. A total of 110 questionnaires were distr...