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5,500
[Amiodarone-induced liver dysfunctions].
Amiodarone, a diiodinated benzofuran derivative, is widely used for treating ventricular and supraventricular tachyarrhythmias. Amiodarone is highly lipophilic and accumulation in the liver can be 500 times higher than serum amiodarone levels. Due to a long half-life and the lipophilic properties, the stored drug is ca...
5,501
Ventricular fibrillation caused by electrocoagulation in monopolar mode during laparoscopic subphrenic mass resection.
Monopolar is usually a safe and effective electrosurgical unit used in laparoscopic general surgery. However, it can cause adverse outcomes and even cardiac arrest. We present a video of laparoscopic subphrenic mass resection using monopolar coagulation during which ventricular fibrillation occurred and from which the ...
5,502
The correlation between left ventricular failure and right ventricular systolic dysfunction occurring in thyrotoxicosis.
Heart failure rarely occurs in patients with thyrotoxicosis (6%), with half of the cases having left ventricular dysfunction (LVD). Although a few studies reported isolated right heart failure in thyrotoxicosis, there has been no evaluation of relationship between LVD and right ventricular dysfunction (RVD).</AbstractT...
5,503
A randomized invasive cardiac electrophysiology study of the combined ion channel blocker AZD1305 in patients after catheter ablation of atrial flutter.
This study assessed the cardiac electrophysiological and hemodynamic effects of an intravenous infusion of the combined ion channel blocker AZD1305.</AbstractText>After successful ablation of atrial flutter, patients were randomized to receive placebo (n = 12) or AZD1305 (n = 38) in 4 ascending dose groups. Electrophys...
5,504
The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction.
The P-Selectin Gene Polymorphism Val168Met.</AbstractText>Ventricular fibrillation (VF) in the setting of acute myocardial infarction (AMI) is the leading cause of sudden cardiac death (SCD). Family history of SCD is described as risk factor for primary VF during acute AMI. Genetic factors may be associated with primar...
5,505
Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets.
Atrial and ventricular tachyarrhythmias can be perpetuated by up-regulation of inward rectifier potassium channels. Thus, it may be beneficial to block inward rectifier channels under conditions in which their function becomes arrhythmogenic (e.g., inherited gain-of-function mutation channelopathies, ischemia, and chro...
5,506
Mechanisms of hypokalemia-induced ventricular arrhythmogenicity.
Hypokalemia is a common biochemical finding in cardiac patients and may represent a side effect of diuretic therapy or result from endogenous activation of renin-angiotensin system and high adrenergic tone. Hypokalemia is independent risk factor contributing to reduced survival of cardiac patients and increased inciden...
5,507
Single-beat determination of right ventricular function in patients with atrial fibrillation.
In atrial fibrillation (AF), left ventricular (LV) systolic function positively correlates with the ratio of the preceding to prepreceding RR intervals (RRp/RRpp) and single-beat determination of LV function at a beat with equal RRp and RRpp closely estimates the average value over all cardiac cycles. The study was des...
5,508
Survival in out-of-hospital cardiac arrest before and after use of advanced postresuscitation care: a survey focusing on incidence, patient characteristics, survival, and estimated cerebral function after postresuscitation care.
Knowledge of the epidemiology of postresuscitation care is insufficient. We describe the epidemiology of postresuscitation care in a community from a 26-year perspective, focusing on incidence, patient characteristics, survival, and estimated cerebral function in relation to intensified postresuscitation care and initi...
5,509
[ILCOR recommendation on signage of automated external defibrillators (AEDs)].
Early defibrillation is a determinant of survival in both out-of-hospital and in-hospital cardiac arrests from ventricular fibrillation and pulseless ventricular tachycardia. The review summarizes importance of early defibrillation with automated external defibrillators (AED) and presents the International Liaison Comm...
5,510
[Gender differences in non-pharmacological treatment of chronic heart failure].
Prior studies demonstrated sex-related differences in many aspects of chronic heart failure (HF), and in the appropriate use, individual response or complication rates with non-pharmacological treatment, too. There is seasonal variability in morbidity and mortality of HF with significant gender differences, partially d...
5,511
Vagal modulation of heart rate variability during atrial fibrillation in pigs.
Atrial fibrillation (AF) is the most common sustained cardiac dysrhythmia and is associated with an increased risk for sudden cardiac death. The ventricular rhythm is irregular and displays both non-linear and linear patterns; however, it has not been determined whether vagally derived patterns are manifest within the ...
5,512
Assessment of mitral bioprostheses using cardiovascular magnetic resonance.
The orifice area of mitral bioprostheses provides important information regarding their hemodynamic performance. It is usually calculated by transthoracic echocardiography (TTE), however, accurate and reproducible determination may be challenging. Cardiovascular magnetic resonance (CMR) has been proven as an accurate a...
5,513
[Idiopathic premature ventricular complexes originating from the ventricular outflow tract: evaluation, prognosis and management].
Idiopathic premature ventricular complexes originating from the ventricular outflow tract: evaluation, prognosis and management The prognosis of ventricular premature complexes (VPC) in the absence of heart disease is considered benign. VPC usually originate from the right or, less commonly, left ventricular outflow tr...
5,514
Investigation of the relationship between venticular fibrillation duration and cardiac/neurological damage in a rabbit model of electrically induced arrhythmia.
To establish a simple, economic, and reliable alternating current (AC)-induced cardiac arrest (ACCA) model in rabbits for cardiopulmonary cerebral resuscitation research.</AbstractText>Ventricular fibrillation was induced in 27 New Zealand rabbits by external transthoracic AC, which were randomly divided into three gro...
5,515
Novel insights into the role of the sympathetic nervous system in cardiac arrhythmogenesis.
It has long been recognized that increased sympathetic nerve activity during physiologic stress (exercise, swimming, emotion, arousal, loud noise, etc.) has profound influences on the electrical and contractile functions of the heart. In the severely predisposed heart, these stressors may lead to ventricular tachyarrhy...
5,516
BIVentricular versus right ventricular antitachycardia pacing to terminate ventricular tachyarrhythmias in patients receiving cardiac resynchronization therapy: the ADVANCE CRT-D Trial.
This multicenter, prospective, randomized, controlled, parallel trial compares the efficacy of biventricular (BIV) versus right ventricular (RV) antitachycardia pacing (ATP) in terminating all kinds of ventricular tachycardia (VT).</AbstractText>Five hundred twenty-six patients implanted with a cardiac resynchronizatio...
5,517
Risk factors and outcome of new-onset cardiac arrhythmias in vascular surgery patients.
The pathophysiology of new-onset cardiac arrhythmias is complex and may bring about severe cardiovascular complications. The relevance of perioperative arrhythmias during vascular surgery has not been investigated. The aim of this study was to assess risk factors and prognosis of new-onset arrhythmias during vascular s...
5,518
A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm.
The efficacy and safety of vernakalant, a relatively atrial-selective antiarrhythmic agent, in converting atrial fibrillation (AF) to sinus rhythm (SR) were evaluated in this multicenter, open-label study of patients with AF lasting &gt;3 hours and &lt; or =45 days (RCT no. NCT00281554).</AbstractText>Adult patients wi...
5,519
Prevalence and prognostic significance of left ventricular dysfunction in patients presenting acutely with atrial fibrillation.
The prevalence and prognostic importance of CM occurring as a consequence of AF is poorly defined. This study investigated the incidence of CM in patients with AF, its clinical features and long-term outcomes. We demonstrated that CM is common in patients presenting acutely with newly diagnosed rapid AF, and carries a ...
5,520
Effect of uncomplicated obesity on QT interval in young men.
QT prolongation and obesity are associated with ventricular arrhythmia and sudden cardiac death. The relationship between uncomplicated obesity and QT interval prolongation is not clear.</AbstractText>The aim of the study was to investigate the effects of uncomplicated obesity on QT interval in young men.</AbstractText...
5,521
[Hypertension and heart].
Arterial hypertension often leads to diseases of kidneys, vessels and brain. Besides these end organ damages the changes of the heart are of important role. Substantial consequences of hypertension are microangiopathy, interstitial fibrosis and left ventricular hypertrophy. Hence, as an early stage diastolic dysfunctio...
5,522
Sudden death in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is regarded as the most common cause of sudden cardiac death in young people (including trained athletes). However, assessing sudden death (SD) risk and identifying the most appropriate candidates for prophylactic device therapy is a complex process compounded by the unpredictability o...
5,523
Hypertrophic cardiomyopathy: the early years.
Hypertrophic obstructive cardiomyopathy (HOCM) has four major features: (1) severe left ventricular hypertrophy, often most prominent in the basal interventricular septum; (2) frequent familial occurrence with autosomal dominant transmission; (3) occurrence of sudden cardiac death that is usually considered to be due t...
5,524
Intramural dyssynchrony from acute right ventricular apical pacing in human subjects with normal left ventricular function.
Ventricular pacing causes early myocardial shortening at the pacing site and pre-stretch at the opposing ventricular wall. This contraction pattern is energetically inefficient and may lead to decreased cardiac function. This study was designed to describe the acute effects of right ventricular apical (RV(a)) pacing on...
5,525
A report of fetal demise during therapeutic hypothermia after cardiac arrest.
Therapeutic hypothermia is becoming the standard-of-care for coma following out-of-hospital cardiac arrest. Pregnancy has been considered a contraindication for therapeutic hypothermia.</AbstractText>Case report.</AbstractText>A 44-year-old woman presented after a witnessed out-of-hospital ventricular fibrillation card...
5,526
Abnormal atrial repolarization and depolarization contribute to the inducibility of atrial fibrillation in Brugada syndrome.
Brugada syndrome is often accompanied by atrial tachyarrhythmia, such as atrial fibrillation (AF). The aim of this study was to examine atrial vulnerability in patients with Brugada syndrome. Two groups of patients were compared: 18 patients with Brugada syndrome (Brugada syndrome group) and 11 age-matched patients wit...
5,527
Tachycardia-induced cardiomyopathy: evaluation and therapeutic options.
Tachycardia-induced cardiomyopathy is caused by sustained rapid ventricular rates and is one of the well-known forms of reversible myocardial dysfunction. The diagnosis is usually made retrospectively after marked improvement in systolic function is noted following control of the heart rate. Physicians should be aware ...
5,528
Assessment of the post-implant final left ventricular lead position: a comparative study between radiographic and angiographic modalities.
Post-implant lateral and postero-anterior chest X-rays (CXR) are often utilized to determine the final LV lead tip position after cardiac resynchronization therapy (CRT). This study sought to compare post-implant standard CXRs with intra-procedural rotational coronary venous angiography (RCVA) to localize the final LV ...
5,529
Cilostazol attenuates ventricular arrhythmia induction and improves defibrillation efficacy in swine.
Previous reports demonstrated that cilostazol, a phosphodiesterase 3 inhibitor, affected cellular electrophysiology and reduced episodes of ventricular fibrillation (VF) in patients with Brugada syndrome. However, its effects on VF induction and defibrillation efficacy have never been investigated. We tested the hypoth...
5,530
[ICD therapy for the primary prevention of sudden cardiac arrest. The patient after a myocardial infarction].
ICD therapy represents a major advance in the treatment of patients with severely impaired left ventricular function after myocardial infarction. While an ICD implantation also remains a valuable option late (&gt;5 years) after myocardial infarction, patients early after this event are at a competitive risk of arrhythm...
5,531
A first city-wide early defibrillation project in a German city: 5-year results of the Bochum against sudden cardiac arrest study.
Immediate defibrillation is the decisive determinant of prognosis in patients suffering from cardiac/circulatory arrest caused by ventricular fibrillation (VF). Therefore, various national and international associations recommend that first responders use defibrillators as soon as possible and also recommend public acc...
5,532
Electrophysiologic study: its predictive value for ventricular arrhythmias.
Studies have shown the predictive value of inducible ventricular tachycardia and clinical arrhythmia in patients who have structural heart disease. We examined the possible predictive value of electrophysiologic study before the placement of an implantable cardioverter-defibrillator. Our retrospective study group compr...
5,533
Review of the management of sudden cardiac arrest on the football field.
Football is the most popular sport on earth. When a young, fit popular player suddenly collapses and dies during play, the tragic event is frequently screened and publicised worldwide. The reported incidence of sudden cardiac arrest (SCA) varies from 1:65,000 to 1:200,000 athletes. A broad spectrum of cardiac and non-c...
5,534
Influence of the On-X mechanical prosthesis on intermediate-term major thromboembolism and hemorrhage: a prospective multicenter study.
Long-term thromboembolic and hemorrhagic outcomes after mechanical valve replacement have been well described; however, few studies have described these outcomes after valve replacement with the On-X mechanical prosthesis (On-X Life Technologies, Inc, Austin, Tex).</AbstractText>Between 2003 and 2008, 737 patients unde...
5,535
Idiopathic ventricular fibrillation in a 10-year-old boy: technical aspects of radiofrequency ablation and utility of antiarrhythmic therapy.
Idiopathic ventricular fibrillation (VF) is defined as spontaneous VF in the absence of structural heart disease. No prior reports exist addressing the technical aspects of idiopathic VF ablation in a child. We present the case of a 10-year-old boy with idiopathic VF, who presented a unique management challenge, partic...
5,536
Left ventricular lateral annulus and left atrial free-wall velocity time integral indicate thromboembolism in patients with rheumatic atrial fibrillation.
Low wall motion and stasis increase the likelihood of clot formation. We hypothesized that tissue Doppler indices of left atrial (LA) motion are reduced in the presence of LA thrombi and may be predictive for clot formation in patients with atrial fibrillation (AF).</AbstractText>We did an observational study for 3 yea...
5,537
Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs.
The induction of deep cerebral hypothermia via ice-cold saline aortic flush during prolonged ventricular fibrillation cardiac arrest, followed by hypothermic stasis and delayed resuscitation (emergency preservation and resuscitation), improved neurologic outcome after cardiac arrest in pigs, as compared to conventional...
5,538
The R820W mutation in the MYBPC3 gene, associated with hypertrophic cardiomyopathy in cats, causes hypertrophic cardiomyopathy and left ventricular non-compaction in humans.
The R820W mutation in the MYBPC3 gene has been associated with the development of hypertrophic cardiomyopathy (HCM) in rag-doll cats, but had not been described in humans.</AbstractText>To describe the phenotype associated with the R820W mutation identified in a human family.</AbstractText>The R820W was identified by d...
5,539
Freedom SOLO valve: early- and intermediate-term results of a single centre's first 100 cases.
The Freedom SOLO aortic valve is a bovine pericardial stentless valve, which requires only one suture line. The aim of our single-centre retrospective study was to assess postoperative and intermediate-term haemodynamic results of the first 100 consecutively implanted valves.</AbstractText>One hundred patients (39 male...
5,540
Ventricular fibrillation diagnosed during electrophysiological study for non-sustained tachycardia.<Pagination><StartPage>593</StartPage><EndPage>596</EndPage><MedlinePgn>593-6</MedlinePgn></Pagination><Abstract><AbstractText>Ventricular fibrillation diagnoses such as Brugada syndrome pose a risk of sudden incapacitati...
Ventricular fibrillation diagnoses such as Brugada syndrome pose a risk of sudden incapacitation or death in aircrew. This case report presents a 44-yr-old male fighter pilot who unexpectedly developed ventricular fibrillation (VF) during an electrophysiological study (EPS) prior to therapy for non-sustained ventricula...
5,541
Structure-based virtual screening and electrophysiological evaluation of new chemotypes of K(v)1.5 channel blockers.
Atrial fibrillation (AF) is the most prevalent nonfatal cardiac rhythm disorder associated with an increased risk of heart failure and stroke. Considering the ventricular side effects induced by anti-arrhythmic agents in current use, K(v)1.5 channel blockers have attracted a great deal of deliberation owing to their se...
5,542
Frequency of sleep apnea in adults with the Marfan syndrome.
Obstructive and central sleep apneas are treatable disorders, which contribute to cardiovascular morbidity in older adults. Younger adults with Marfan syndrome may also be at risk for sleep apnea, but the relation between cardiovascular complications and sleep apnea is unknown. We used MiniScreen8 portable monitoring d...
5,543
Outpatient cardiology practices with advanced practice nurses and physician assistants provide similar delivery of recommended therapies (findings from IMPROVE HF).
National guidelines recommend a team model of care to facilitate adherence to evidence-based practices; however, previous studies suggesting benefit may have limited generalizability. The aim of this study was to examine the influence of advanced practice nurse (APN) and physician assistant (PA) staffing on the deliver...
5,544
Impact of lipid-lowering therapy on outcomes in atrial fibrillation.
Lipid-lowering therapy (LLT) decreases mortality in select patient populations. LLT has also been shown to have antiarrhythmic effects, thus favorably influencing the incidence and recurrence of atrial fibrillation (AF). However, data are lacking regarding the effect of LLT on mortality in patients with AF. The Atrial ...
5,545
Percutaneous removal of endocardial implantable cardioverter-defibrillator lead displaced to the right pulmonary artery.
We describe a case of percutaneous removal of endocardial implantable cardioverter-defibrillator lead displaced to the right pulmonary artery. The procedure was performed from two accesses; from the lower one (femoral) and then, due to technical problems, from the upper one (subclavian). In the last stage the flattened...
5,546
Electrocardiographic correlates of microalbuminuria in adult Nigerians with essential hypertension.
Microalbuminuria (MA) is a predictor of excess cardiovascular morbidity and mortality in non-diabetic hypertensive patients. This study evaluated the electrocardiographic correlates of MA in adult non-diabetic Nigerians with essential hypertension. Ninety-six newly diagnosed hypertensive patients who consented and met ...
5,547
[Safety of magnetic resonance imaging in patients with pacemaker and implantable defibrillator].
The presence of a cardiac implantable device is ICD considered an absolute contraindication to magnetic resonance imaging (MRI). The purpose of this study was to evaluate the safety of performing MRI in patients with cardiac pacemakers and ICDs that had a compelling clinical need for MRI examination.</AbstractText>Duri...
5,548
[Mistaking a long QT syndrome for epilepsy: does every seizure call for an ECG?].
Syncope is a common and difficult differential diagnosis for epilepsy. One possible cause for a cardiac syncope is a long QT syndrome (LQTS). LQTS with torsade de pointes tachycardia can lead to lethal ventricular fibrillation and cardiac arrest. Patients with LQTS when first diagnosed as suffering from epileptic fits ...
5,549
[Pacemaker ECG quiz no. 22. A CRT non-responder with atrial fibrillation].
A patient with heart failure functional class NYHA III and permanent atrial fibrillation received a system for cardiac resynchronization therapy. Unfortunately, he reports at a follow-up visit about a completely unchanged poor exercise capacity with dyspnea during exercise at a very low level. The ECG reveals an unusua...
5,550
Amiodarone-induced QT prolongation in a newly transplanted heart associated with recurrent ventricular fibrillation.
Anti-arrhythmic drugs such as amiodarone have the potential to prolong QT intervals, which can result in torsades de point arrhythmia. It is unknown whether amiodarone, given to a recipient prior to cardiac transplantation, can cause arrhythmia in a newly transplanted donor heart. We report on a case of a 71-year-old m...
5,551
Catheter ablation for paroxysmal atrial fibrillation: a randomized comparison between multielectrode catheter and point-by-point ablation.
Catheter ablation for paroxysmal atrial fibrillation is widely used for patients with drug-refractory paroxysms of arrhythmia. Recently, novel technologies have been introduced to the market that aim to simplify and shorten the procedure.</AbstractText>&#x2002;To compare the clinical outcome of pulmonary vein (PV) isol...
5,552
Statins and the reduction of sudden cardiac death: antiarrhythmic or anti-ischemic effect?
Sudden cardiac death is an important cause of cardiovascular mortality with the majority of cases occurring in low-risk groups. HMG-CoA reductase inhibitors (statins) have recently been shown to reduce the incidence of ventricular tachycardia (VT)/fibrillation (VF) and sudden cardiac death, and this has been attributed...
5,553
Heart rate and systolic blood pressure in patients with persistent atrial fibrillation. A linguistic analysis.
During atrial fibrillation (AF), ventricular response is highly irregular and thus the beat-to-beat variation of blood pressure is increased because of variations in filling time and in contractility.</AbstractText>Aim of the present study is to investigate the short-term dynamics of RR and SAP series in patients with ...
5,554
Implantable cardioverter-defibrillator shock: appropriate or inappropriate?
A 76-year-old female with a single chamber implantable cardioverter-defibrillator implanted for secondary prevention was referred due to multiple discharges. The device was programmed for ventricular tachycardia (VT) detection at 400 ms, fast VT detection at 280 ms, and ventricular fibrillation detection at 320 ms. Ant...
5,555
Fragmented QRS in prediction of cardiac deaths and heart failure hospitalizations after myocardial infarction.
Increased QRS fragmentation in visual inspection of 12-lead ECG has shown association with cardiac events in postmyocardial infarction (MI) patients. We investigated user-independent computerized intra-QRS fragmentation analysis in prediction of cardiac deaths and heart failure (HF) hospitalizations after MI.</Abstract...
5,556
[Is intraoperative ICD-testing still necessary?].
Intraoperative ICD-testing is traditionally performed in many hospitals in order to ensure reliable sensing, detection, and defibrillation of induced ventricular fibrillation. The technical progress of defibrillators allows rapid detection and delivery of high energy shocks which defibrillates effectively in the vast m...
5,557
ALLHAT: still providing correct answers after 7 years.
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is re-evaluated considering information from recent subgroup and exploratory analyses, other new clinical trials, and meta-analyses. The ALLHAT analyses specifically emphasize heart failure findings, results in Black participants a...
5,558
Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study.
The inverse association between plasma B-type natriuretic peptide (BNP) levels and body mass index (BMI) has been reported in Western populations. Here we analyzed the relationship between plasma BNP and obesity in a general urban Japanese population. We recruited 1,759 subjects without atrial fibrillation or history o...
5,559
Ventricular fibrillation in a man shot with a Taser.
Controversy exists concerning the lethality of Tasers. These are conducted electrical weapons which incapacitate subjects by delivering an electrical charge that causes diffuse muscle contraction. In North America, over 440 deaths have been reported immediately following Taser use. Taser International has recently sugg...
5,560
Uric acid elevation in atrial fibrillation.
Uric acid is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. We therefore investigated the association between AF and uric acid levels.</AbstractText>Consecutive patients with AF and healthy co...
5,561
Hospitalized lithium overdose cases reported to the California Poison Control System.
Lithium overdose primarily results in neurologic toxicity; however, cardiac effects have also been reported. Our aim was to describe a large cohort of hospitalized lithium overdose patients. Specifically we were interested in reported cardiac complications, frequency of hemodialysis (HD), and mortality.</AbstractText>T...
5,562
[Risk stratification in non ischemic cardiomyopathy: a case report--Case 5/2010].
A 65-year-old male patient with rapid increasing shortness of breath and newly diagnosed atrial fibrillation was admitted to our hospital.</AbstractText>The ECG revealed atrial fibrillation. Echocardiography showed severe decreased left ventricular function. The magnetic resonance imaging (MRI) scan confirmed the sever...
5,563
Coexisting sustained tachyarrthymia in patients with atrial fibrillation undergoing catheter ablation.
During the index procedure of catheter ablation (CA) for atrial fibrillation (AF), it is important to assess whether other atrial or ventricular tachyarrhythmia coexist. Their symptoms are often attributed to residual tachycardia after successful elimination of AF by CA. This tachycardia could also be non-pulmonary vei...
5,564
Clinicopathological profiles of progressive heart failure in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is an important cause of heart failure-related disability over a wide range of ages. Profiles of severe progressive heart failure symptoms and death, or heart transplantation deserve more complete definition within large patient cohorts.</AbstractText>Clinical and morphological feature...
5,565
The Utility of Ambulatory Electrocardiographic Monitoring for Detecting Silent Arrhythmias and Clarifying Symptom Mechanism in an Urban Elderly Population with Heart Failure and Hypertension: Clinical Implications.
<b>Background:</b> Atrial and ventriclar tachyarrhythmias, as well as bradyarrhythmias, in the elderly with heart failure (HF) and/or hypertension (HTN) have been well documented. However, the frequency of these arrhythmias, whether silent or symptomatic, and their association with subsequent cardiac events has not bee...
5,566
Antiarrhythmic and nonantiarrhythmic drugs for sudden cardiac death prevention.
Life-threatening ventricular arrhythmias such as sustained ventricular tachycardia and ventricular fibrillation are responsible for two thirds of sudden cardiac deaths annually in the United States. Implantable cardioverter-defibrillator (ICD) therapy prevents mortality from arrhythmic death but is expensive and has so...
5,567
Diagnostic performance of a new multifunctional electrocardiograph during uninterrupted chest compressions in cardiac arrest patients.
External chest compression is considered to play a significant role in cardiopulmonary resuscitation (CPR), but during a rhythm check, chest compressions must be discontinued to avoid artifacts. A new multifunctional electrocardiograph (ECG; Radarcirc) has been developed for use in clinical settings.</AbstractText>The ...
5,568
Effects of angiotensin receptor blockade on atrial electrical remodelling and the 'second factor' in a goat burst-paced model of atrial fibrillation.
Atrial fibrillation (AF) is self-perpetuating, via mechanisms of acute electrical remodelling and 'second factors' acting over a longer time course. Renin-angiotensin system (RAS) blockade may inhibit AF self-perpetuation. We evaluated the effects of RAS blockade with candesartan in a burst-paced goat model of lone AF ...
5,569
[Remote control in ICD therapy].
In several studies, ICD therapy has been shown to be an effective treatment option for patients suffering from or being at risk of malignant ventricular arrhythmias. Given the increasing rate of ICD implantations with the need for in-office interrogations at least twice a year, the number of follow-up visits is constan...
5,570
Reduction in the intensity rate of appropriate shocks for ventricular arrhythmias with statin therapy.
Higher rate of implantable cardioverter-defibrillator (ICD) shocks has been associated with increased mortality and morbidity. The aim of our study was to determine whether statins reduced the intensity rate of appropriate shock therapy for ventricular tachycardia/fibrillation in patients with an ICD placed for left ve...
5,571
[Implantable cardioverter-defibrillator oversensing due to electric shock].
We described the first case of oversensing due to electric shock in Serbia, in a 54-year-old man who had implantable cardioverter-defibrillator (ICD).</AbstractText>In July 2002, the patient had acute anteroseptal myocardial infarction and ventricular fibrillation (VF) which was terminated with six defibrillation shock...
5,572
[Relationship between mortality of patients with atrial fibrillation and mortality of general population in Serbia].
Large population-based observational trials have shown atrial fibrillation (AF) to be an independent risk factor for increased mortality.</AbstractText>To examine all-cause mortality and cardiovascular mortality of patients with AF compared to corresponding mortality in general population of Serbia.</AbstractText>This ...
5,573
Ventricular fibrillation due to coronary spasm at the site of myocardial bridge -A case report-.
Myocardial bridge is a congenital anomaly characterized by narrowing of some of the epicardial coronary arterial segments running in the myocardium during systole. Occasionally, the compression of a coronary artery by a myocardial bridge can be associated with the clinical manifestations of myocardial ischemia, and mig...
5,574
Beta-blockers for chest pain associated with recent cocaine use.
Although beta-blockers prevent adverse events after myocardial infarction, they are contraindicated when chest pain is associated with recent cocaine use. Recommendations against this use of beta-blockers are based on animal studies, small human experiments, and anecdote. We sought to test the hypothesis that beta-bloc...
5,575
Clinical trials update from the American College of Cardiology meeting 2010: DOSE, ASPIRE, CONNECT, STICH, STOP-AF, CABANA, RACE II, EVEREST II, ACCORD, and NAVIGATOR.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure presented at the annual meeting of the American College of Cardiology held in March 2010. Unpublished reports should be considered as preliminary, since analyses may change in the fina...
5,576
Primary prevention of sudden cardiac death by implantable cardioverter-defibrillator therapy in Chinese patients with heart failure: a single-center experience.
An implantable cardioverter-defibrillator (ICD) has been suggested for heart failure patients for primary prevention of sudden cardiac death. However, few data have been reported on the application of ICD as primary prevention of sudden cardiac death in China. We evaluated the value of primary prevention ICD therapy in...
5,577
Distribution of echocardiographic parameters and their associations with cardiovascular risk factors in the Rotterdam Study.
Insight into echocardiographic parameters in the general population may facilitate early recognition of ventricular dysfunction, reducing the population morbidity and mortality of heart failure. We examined the distribution of structural, systolic and diastolic echocardiographic parameters and their associations with c...
5,578
Non-invasive diagnosis of coronary-subclavian steal: role of the Doppler ultrasound.
Coronary subclavian steal syndrome (CSSS) is a well documented cause of graft function failure in patients after left internal mammary artery (LIMA)--left anterior descending (LAD) coronary artery grafting. We present a case of the CSSS in a patient with cardiac arrest due to ventricular fibrillation. To our knowledge ...
5,579
Resuscitation after prolonged cardiac arrest: role of cardiopulmonary bypass and systemic hyperkalemia.
The purpose of this study was to determine (1) the role of emergency cardiopulmonary bypass (CPB) after prolonged cardiac arrest and failed cardiopulmonary resuscitation, and (2) the use of systemic hyperkalemia during CPB to convert intractable ventricular fibrillation (VF).</AbstractText>Thirty-one pigs (34 +/- 2 kg)...
5,580
Predictors of successful defibrillation threshold test during CRT-D implantation.
The assessment of defibrillation energy requirement (DER) is a standard practice during cardioverter-defibrillator (ICD) implantation. It is recommended to assure that the energy at least 10 J below the maximal energy deliverable by the implanted device successfully converts the induced ventricular fibrillation (VF). T...
5,581
Breathing patterns during cardiac arrest.
The absence of respiratory movements is a major criterion recommended for use by bystanders for recognizing an out-of-hospital cardiac arrest (CA), as the persistence of eupneic breathing is considered to be incompatible with CA. The basis for CA-related apnea is, however, uncertain, since brain stem Po(2) is not expec...
5,582
Prevention of atrial fibrillation by Renin-Angiotensin system inhibition a meta-analysis.
The authors reviewed published clinical trial data on the effects of renin-angiotensin system (RAS) inhibition for the prevention of atrial fibrillation (AF), aiming to define when RAS inhibition is most effective.</AbstractText>Individual studies examining the effects of RAS inhibition on AF prevention have reported c...
5,583
Reverse electrical remodeling of the ventricles following successful restoration of sinus rhythm in patients with persistent atrial fibrillation.
Atrial fibrillation (AF) has been shown to be associated with reduced survival and increased ventricular arrhythmogenesis. The purpose of this study was to assess the effects of AF with adequate rate control on the electrophysiologic properties of the ventricles. We hypothesized that AF results in increased ventricular...
5,584
Exercise-induced natriuretic peptide secretion predicts cardioversion outcome in patients with persistent atrial fibrillation: discordant ANP and B-type natriuretic peptide response to exercise testing.
Measurement of natriuretic peptide's (NP) release in response to hemodynamic stress may be complementary to its baseline assessment in individuals. Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) increase in patients with atrial fibrillation (AF) and decrease after successful cardioversion, sugges...
5,585
Ventricular pauses during atrial fibrillation predict relapse after electrical cardioversion: a prospective study.
To investigate the use of ambulatory electrocardiogram (ECG) monitoring in atrial fibrillation (AF) to predict recurrence after electrical cardioversion (ECV).</AbstractText>RR interval variables were obtained from 24 hours ECGs recorded before ECV in 119 patients (85 men, age 66 +/- 10 years) with persistent AF. Patie...
5,586
Therapy with renin-angiotensin system blockers after pulmonary vein isolation in patients with atrial fibrillation: who is a responder?
The data on anti-arrhythmic effect of renin-angiotensin-aldesteron system blockers (RASB) in patients with atrial fibrillation (AF) are controversially discussed. The goal of this analysis was to identify cohort of patients with AF and hypertension, who may have benefit from RASB therapy after pulmonary vein isolation ...
5,587
Low-risk profile for malignant ventricular arrhythmias and sudden cardiac death after surgical ventricular reconstruction.
Although it has been recently demonstrated that there was no significant difference in total survival and clinical outcomes between patients who underwent coronary artery bypass grafting (CABG) with or without surgical ventricular reconstruction (SVR), the question of whether or not SVR decreases the arrhythmic risk pr...
5,588
Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation.
Periods of Highly Organized Activation During VF.</AbstractText>Little is known about long-duration ventricular fibrillation (LDVF), lasting 1-10 minutes when resuscitation is still possible.</AbstractText>To determine global left ventricle (LV) endocardial activation during LDVF, 6 canines (9.5 &#xb1; 0.8 kg) received...
5,589
Autonomic dysfunction and new-onset atrial fibrillation in patients with left ventricular systolic dysfunction after acute myocardial infarction: a CARISMA substudy.
Atrial fibrillation (AF) increases morbidity and mortality in patients with previous myocardial infarction and left ventricular systolic dysfunction. The purpose of this study was to identify patients with a high risk for new-onset AF in this population using invasive and noninvasive electrophysiological tests.</Abstra...
5,590
Ventricular tachyarrhythmia associated with hypertrophic cardiomyopathy: incidence, prognosis, and relation to type of hypertrophy.
To assess the incidence, characteristics, and prognosis of ventricular tachyarrhythmia in hypertrophic cardiomyopathy (HCM).</AbstractText>The study consisted of 66 consecutive patients with HCM who were admitted to Niigata University Hospital between 1992 and 2005. Their clinical characteristics and ECG morphology wer...
5,591
The relation between the color M-mode propagation velocity of the descending aorta and coronary and carotid atherosclerosis and flow-mediated dilatation.
To improve clinical outcomes, noninvasive imaging modalities have been proposed to measure and monitor atherosclerosis. Common carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation (FMD) have correlated with coronary atherosclerosis. Recently, the color M-mode-derived propagation velocity o...
5,592
Intracardiac echocardiography in electrophysiology.
Intracardiac echocardiography (ICE) is a recent, invaluable tool which can provide real-time anatomical guidance in electrophysiological procedures. By inserting intravenously an ultrasound probe and advancing it into the heart, various different views can be obtained which allow to better visualize patient anatomy, to...
5,593
Chronic kidney disease as an independent risk factor for new-onset atrial fibrillation in hypertensive patients.
Chronic kidney disease (CKD) has recently been recognized to be a powerful predictor of cardiovascular morbidity and mortality. Atrial fibrillation (AF), which is a common arrhythmia in hypertensives, is associated with increased risks of cardiovascular events and death. However, the association between CKD and the ons...
5,594
Single-site Bachmann's bundle pacing is beneficial while coronary sinus pacing results in echocardiographic right heart pacemaker syndrome in brady-tachycardia patients.
It has been proposed that multisite atrial pacing (MSAp) restores atrial electrical activation and prevents atrial fibrillation recurrence; however, single-site Bachmann's bundle pacing (BBp) has also been reported as providing effective atrial resynchronization. Coronary sinus pacing (CSp) leads to reversed impulse pr...
5,595
Short-term fluctuations of plasma NT-proBNP levels in patients with new-onset atrial fibrillation: a way to assess time of onset?
The objective of this study was to characterise short-term kinetics of plasma amino-terminal pro-B natriuretic peptide (NT-proBNP) levels in patients with new-onset atrial fibrillation (AF) without heart failure.</AbstractText>Prospective cohort study.</AbstractText>Emergency departments and inpatient services of three...
5,596
Delayed versus immediate defibrillation for out-of-hospital cardiac arrest due to ventricular fibrillation: A systematic review and meta-analysis of randomised controlled trials.
Human studies over the last decade have indicated that delaying initial defibrillation to allow a short period of cardiopulmonary resuscitation (CPR) may promote a more responsive myocardial state that is more likely to respond to defibrillation and result in increased rates of restoration of spontaneous circulation (R...
5,597
Incidence of re-arrest and critical events during prolonged transport of post-cardiac arrest patients.
To determine the feasibility of transporting post-cardiac arrest patients to tertiary-care facilities, the rate of re-arrest, and the rate of critical events during critical care transport team (CCTT) care.</AbstractText>Retrospective chart review of cardiac arrest patients transported via CCTT between 1/1/2001 and 5/3...
5,598
Mechanisms underlying the antifibrillatory action of hyperkalemia in Guinea pig hearts.
Hyperkalemia increases the organization of ventricular fibrillation (VF) and may also terminate it by mechanisms that remain unclear. We previously showed that the left-to-right heterogeneity of excitation and wave fragmentation present in fibrillating guinea pig hearts is mediated by chamber-specific outward conductan...
5,599
Intracardiac echocardiography in complex cardiac catheter ablation procedures.
With the availability of catheter ablation for the elimination of complex cardiac arrhythmias, new imaging tools have enhanced the safety and efficacy of procedures performed in the electrophysiology laboratory. We review the use of intracardiac ultrasound (ICE) as the modality that allows real-time monitoring and reco...