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5,600
[Life-threatening brady- and tachyarrhythmias].
Bradycardic (heart rate<50/min) and tachycardic heart rhythm disturbances (100/min) require rapid therapeutic strategies. Supraventricular tachycardias (SVT) are sinus tachycardia, atrial tachycardia, AV-nodal reentrant tachycardia and tachycardia due to accessory pathways. Mostly SVT are characterized by small QRS ...
5,601
Emergency revascularization procedures in patients with acute ST-elevation myocardial infarction due to acute total occlusion of unprotected left main coronary artery: a report of five cases.
Several studies have compared the efficacy of elective coronary artery stenting and coronary artery bypass grafting (CABG) in patients with unprotected left main coronary artery (ULMCA) disease. However, a definite reperfusion modality has yet to be established in ST-elevation myocardial infarction (STEMI) due to acute...
5,602
The influence of left ventricular diameter on left atrial appendage size and thrombus formation in patients with dilated cardiomyopathy.
Patients with dilated cardiomyopathy are considered a high risk group for left ventricular (LV) thrombus formation. However, the left atrial appendage (LAA) might be an additional site for thrombus formation in this patient group. We evaluated the association between LV size and left atrium/LAA size and determined the ...
5,603
Inverted graft insertion technique for apicoaortic bypass.
The proximal anastomosis of the apicoarotic bypass is technically demanding. We describe our novel surgical technique to reinforce the proximal anastomosis of the apicoaortic bypass. After moving circular muscle of the left ventricle (LV) under ventricular fibrillation, an inverted tube graft is inserted into LV throug...
5,604
[Evolution and thromboembolic complications of the idiopathic peripartal cardiomyopathy at Dakar University Hospital: forward-looking study about 33 cases].
The aims of this work are to study the nursery futures during idiopathic myocardiopathy of peripartum (IMPP), to measure the prevalence of thromboses and spontaneous contrast during the IMPP and to determine their evolution.</AbstractText>It is about a longitudinal exploratory study carried out with the Aristide-Le-Dan...
5,605
Pravastatin attenuates cardiac dysfunction induced by lysophosphatidylcholine in isolated rat hearts.
Lysophosphatidylcholine (LPC), which accumulates in the ischemic myocardium, is responsible for mechanical and metabolic derangements of hearts, and also contributes to the development of ventricular arrhythmias. We examined the effects of pravastatin on the LPC-induced cardiac dysfunction in isolated rat hearts. Rat h...
5,606
Comparison of the effects of methadone and heroin on human ether-&#xe0;-go-go-related gene channels.
Torsades de pointes (TdP) is a life-threatening form of ventricular arrhythmia that occurs under conditions of delayed cardiac repolarization indicated by prolonged QT intervals in ECG recordings. The main mechanism of QT prolongation and TdP is block of the rapid component of the cardiac delayed rectifier K(+) current...
5,607
Initial serum glucose level and white blood cell predict ventricular arrhythmia after first acute myocardial infarction.
The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications.</AbstractText>This is a 10-year retrospective cohort study. Patients...
5,608
An entirely subcutaneous implantable cardioverter-defibrillator.
Implantable cardioverter-defibrillators (ICDs) prevent sudden death from cardiac causes in selected patients but require the use of transvenous lead systems. To eliminate the need for venous access, we designed and tested an entirely subcutaneous ICD system.</AbstractText>First, we conducted two short-term clinical tri...
5,609
Genetic basis of malignant channelopathies and ventricular fibrillation in the structurally normal heart.
Sudden cardiac death occurs in a minority of patients in the absence of structural or functional abnormalities. In this category, pure electrical heart diseases are responsible for a large number of these unexpected deaths. These conditions include the long QT syndrome, Brugada syndrome, catecholaminergic polymorphic v...
5,610
[A patient with aortic valve stenosis and severe obstruction of the left ventricular outflow tract: a diagnostic challenge].
A 83-year-old male patient was admitted with dyspnoe and paroxysmal atrial fibrillation. A severe aortic stenosis was diagnosed 9 months before.</AbstractText>Echocardiography now revealed severe obstruction of the left ventricular outflow tract, as part of an obstructive cardiomyopathy, mild aortic valve stenosis and ...
5,611
Induction by direct current pulse versus 50-Hz pacing on ventricular fibrillation and defibrillation.
Ventricular fibrillation (VF) induced by different modes of induction may have different characteristics and defibrillation thresholds. This study compares the cycle lengths and defibrillation of VF induced by direct current (DC) pulses vs 50&#xa0;Hz.</AbstractText>We compared induction by DC pulses and 50-Hz pacing in...
5,612
A left ventricular epicardial to right ventricular endocardial dominant frequency gradient exists in human ventricular fibrillation.
We hypothesized that in patients with left ventricular dysfunction undergoing implant of a biventricular ICD, the local dominant frequency during early induced ventricular fibrillation would be higher at an epicardial left ventricular position compared to an endocardial right ventricular position.</AbstractText>Patient...
5,613
The molecular mechanism of protective effects of grape seed proanthocyanidin extract on reperfusion arrhythmias in rats in vivo.
Reperfusion arrhythmias (RA) especially ventricular tachycardia (VT) and ventricular fibrillation (VF) remain the most important causes of sudden death following reperfusion. In isolated rat hearts grape seed proanthocyanidin extract (GSPE) had been proved to reduce the incidence of reperfusion-induced VF and VT. Howev...
5,614
Fundamental frequency and regularity of cardiac electrograms with Fourier organization analysis.
Dominant frequency analysis (DFA) and organization analysis (OA) of cardiac electrograms (EGMs) aims to establish clinical targets for cardiac arrhythmia ablation. However, these previous spectral descriptions of the EGM have often discarded relevant information in the spectrum, such as the harmonic structure or the sp...
5,615
[Effect of beta-adrenoblockers on remodeling of myocardium and adhesive function of endothelium in patients with ischemic heart disease, complicated with chronic heart failure and atrial fibrillation].
To elucidate effect of adrenoblockers on remodeling of myocardium and adhesive function of endothelium in with ischemic heart disease with chronic heart failure (CHF) and addition of atrial fibrillation (AF).</AbstractText>We included into the study 77 patients with functional class II-III CHF and AF of ischemic genesi...
5,616
Prevalence of atrial fibrillation in hospitalized patients over 40 years old: ten-year data from the People's Hospital of Peking University.
The risk factors for atrial fibrillation (AF) are complicated and multifactorial. In the present study we investigated the prevalence of atrial fibrillation in China.</AbstractText>The inpatient medical records of patients over 40 years with AF in the People's Hospital of Peking University from October 1998 to Septembe...
5,617
Admission glucose level and in-hospital outcomes in diabetic and non-diabetic patients with acute myocardial infarction.
Hyperglycemia on admission is a predictor of unfavorable prognosis in patients with acute myocardial infarction (AMI). Data concerning associations between elevated glucose level on admission and other in-hospital complications are still limited.</AbstractText>A total of 607 AMI patients with complete admission glucose...
5,618
Acquired noncompaction associated with coronary heart disease and myopathy.
In a 77-year-old man with a history of arterial hypertension, coronary heart disease, dilative cardiomyopathy, mitral and tricuspid insufficiency, arteriovenous block III, implantation of a pacemaker, atrial fibrillation, and heart failure, left ventricular hypertrabeculation (LVHT) was detected on transthoracic echoca...
5,619
Risk factors for recurrent heart failure events in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).
Risk Factors for Recurrent Heart Failure.</AbstractText>This study was designed to identify risk factors for recurrent heart failure (HF) events in patients with ischemic left ventricular dysfunction enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).</AbstractText>The Prentice, Willia...
5,620
J-wave disappearance immediately after an episode of ventricular fibrillation in a patient with resuscitated sudden cardiac death and Brugada syndrome.
Early repolarization (ER) abnormalities in the inferior-lateral leads are a matter of intense scientific debate because of their demonstrated association with Brugada syndrome (BS) and idiopathic ventricular fibrillation (VF). To add fuel to the fire, we present a case in which ER abnormalities are associated with BS b...
5,621
Safety of remote magnetic navigation in patients with pacemakers and implanted cardioverter defibrillators.
Remote magnetic catheter navigation (MNS) has been shown to be feasible and safe for radiofrequency catheter ablation of various cardiac arrhythmias. However, its safety in patients with implanted pacemakers or cardioverter-defibrillators has not yet been studied.</AbstractText>This retrospective case series study inte...
5,622
Post-conditioning with cyclosporine A fails to reduce the infarct size in an in vivo porcine model.
Cyclosporine A has generated intense interest in the field of cardioprotection due to its ability to protect the mitochondria at reperfusion by blocking the opening of the mitochondrial permeability transition pore. The aim of our study was to examine the cardioprotective effect of Sandimmun, a clinically available for...
5,623
Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic stroke: a prospective study.
Ischemic stroke is a frequent pathology with high rate of recurrence and significant morbidity and mortality. There are several causes of stroke, affecting prognosis, outcomes, and management, but in many cases, the etiology remains undetermined. We hypothesized that atrial fibrillation was involved in this pathology b...
5,624
Ventricular fibrillation induced by radiofrequency ablation for slow ventricular tachycardia associated with left ventricular dysfunction.
A 59-year-old man with premature ventricular contractions (PVCs) and slow ventricular tachycardia (VT) underwent electrophysiologic testing. The left ventricular ejection fraction was 27%. Activation mapping showed the site of earliest activation to be the posterolateral site of the right ventricle inflow tract, and we...
5,625
Mechanisms of defibrillation.
Electrical shock has been the one effective treatment for ventricular fibrillation for several decades. With the advancement of electrical and optical mapping techniques, histology, and computer modeling, the mechanisms responsible for defibrillation are now coming to light. In this review, we discuss recent work that ...
5,626
[Study on effect of total flavonoids from Scutellaria amoena on experimental arrhythmia].
To observe the effect of total flavonoids from Scutellaria amoena on the experimental arrhythmia.</AbstractText>Experimental animals anesthetized with 10% chloral hydrate were evenly randomized into control group, positive control group, and low-dose, middle-dose and high-dose total flavonoids groups. The experimental ...
5,627
New standards in hypertension and cardiovascular risk management: focus on telmisartan.
Blockade of the renin-angiotensin system is an important approach in managing high blood pressure, and has increasingly been shown to affect cardiovascular disease processes mediated by angiotensin II throughout the cardiovascular and renal continua. Telmisartan is an angiotensin II receptor blocker (ARB) displaying un...
5,628
Extending the boundaries of cardiac resynchronization therapy: efficacy in atrial fibrillation, New York heart association class II, and narrow QRS heart failure patients.
Large-scale clinical trials have demonstrated the benefits of cardiac resynchronization therapy (CRT) in patients with New York Heart Association (NYHA) Class III/IV heart failure, systolic left ventricular dysfunction, and a wide QRS. However, additional patient groups may also benefit from CRT.</AbstractText>We meta-...
5,629
Usefulness of left ventricle dyssynchrony assessment before cardiac resynchronization implantation.
A number of trials have demonstrated the effect of cardiac resynchronization therapy (CRT) on functional improvement and reversed left ventricle remodeling. Meeting contemporary guidelines approximately 30- 40% of patients do not respond to CRT (non-responders).</AbstractText>To quantify the predictive ability of basal...
5,630
Left atrial asynchrony is a major predictor of 1-year recurrence of atrial fibrillation after electrical cardioversion.
The level of atrial mechanical asynchrony may vary within the atrial fibrillation population and this may have pathophysiological relevance.</AbstractText>We sought to verify whether the degree of left-atrial mechanical asynchrony associated with atrial fibrillation is a predictor of arrhythmia recurrence after restora...
5,631
Myxoid adrenal cortical carcinoma presenting as primary hyperaldosteronism: case report and review of the literature.
The authors report a case of myxoid adrenal cortical carcinoma (ACC) clinically manifesting as primary hyperaldosteronism. The 82-year-old female patient had a history of hypertension and was sent to the emergency room because of change in consciousness. Ventricular fibrillation occurred, and severe hypokalemia was fou...
5,632
Overview of electrocardiographic findings and clinical presentation of common cardiac arrhythmias.
To review the components and interpretation of the 12-lead electrocardiogram (ECG) and compare and contrast the ECG waveforms and clinical presentation associated with major cardiac arrhythmias.</AbstractText>A 12-lead ECG reflects the electrical activity of the heart from many different perspectives, and individual le...
5,633
Pharmacotherapeutic decision-making for patients with atrial fibrillation.
To discuss the therapeutic goals in patients with atrial fibrillation (AF); antithrombotic, rate-control, and rhythm-control medications used in these patients; rationale for choosing between rate-control and rhythm-control strategies; and safety, efficacy, and patient-specific considerations in choosing among establis...
5,634
First responder resuscitation teams in a rural Norwegian community: sustainability and self-reports of meaningfulness, stress and mastering.
Training of lay first responder personnel situated closer to the potential victims than medical professionals is a strategy potentially capable of shortening the interval between collapse and start of cardiopulmonary resuscitation (CPR) in cases of out-of-hospital cardiac arrest. In this study we trained lay first resp...
5,635
In-treatment reduced left atrial diameter during antihypertensive treatment is associated with reduced new-onset atrial fibrillation in hypertensive patients with left ventricular hypertrophy: The LIFE Study.
It is unclear whether improvement of left atrial (LA) and ventricular (LV) structure results in reduction in new-onset atrial fibrillation (AF). The aim of the present study was to examine whether changes in-treatment LA diameter were related to changes in risk of new-onset AF.</AbstractText>We followed 939 hypertensiv...
5,636
Challenging the superiority of amiodarone for rate control in Wolff-Parkinson-White and atrial fibrillation.
The objective of this review is to explore and challenge the superiority of amiodarone for rate control in Wolff-Parkinson-White syndrome and concomitant atrial fibrillation (WPW-AF). The current recommendation for pharmacological treatment of this condition is amiodarone. A review of the past 25 years of literature fi...
5,637
Dronedarone in patients with congestive heart failure: insights from ATHENA.
Dronedarone is a new multichannel blocking antiarrhythmic drug for treatment of atrial fibrillation (AF). In patients with recently decompensated congestive heart failure (CHF) and depressed LV function, the drug was associated with excess mortality compared with a placebo group. The present study aimed to analyse in d...
5,638
Cardiac arrest outside and inside hospital in a community: mechanisms behind the differences in outcome and outcome in relation to time of arrest.
The aim was to compare characteristics and outcome after cardiac arrest where cardiopulmonary resuscitation was attempted outside and inside hospital over 12 years.</AbstractText>All out-of-hospital cardiac arrests (OHCAs) in G&#xf6;teborg between 1994 and 2006 and all in-hospital cardiac arrests (IHCAs) in 1 of the ci...
5,639
Uni- or bi-ventricular hypertrophy and susceptibility to drug-induced torsades de pointes.
Cardiac hypertrophy is an independent risk factor for torsades de pointes (TdP), a polymorphic ventricular tachycardia that is often drug-induced, that may evolve into ventricular fibrillation and sudden death. Therefore this study was designed to determine if right (RVH), left (LVH), or biventricular (BVH) hypertrophy...
5,640
K+ channels in the heart: new insights and therapeutic implications.
K+ channels in the heart shape the cardiac action potential, and many existing drugs can inhibit or activate these currents. In particular, their potential therapeutic benefit has been explored in the treatment and prevention of abnormal heart rhythm. Their use in the management of malignant ventricular arrhythmias has...
5,641
The differential method of phase space matrix for AF/VF discrimination application.
The advances in electrocardiographic (ECG) technology have facilitated the development of numerous successful clinical applications and commercial monitoring products for diagnosing disease and monitoring health. All of these demand the development of smart algorithms and computational resources for the real-time, earl...
5,642
Antiarrhythmic use from 1991 to 2007: insights from the Canadian Registry of Atrial Fibrillation (CARAF I and II).
The pharmacologic management of atrial fibrillation (AF), the most common sustained cardiac arrhythmia, has been traditionally dichotomized into control of ventricular rate or re-establishment and maintenance of sinus rhythm.</AbstractText>The purpose of this study was to evaluate the use of rate-controlling drugs and ...
5,643
Multiple embolisations in rheumatic heart disease: a case report.
Though systemic thromboembolism is not an infrequent complication of rheumatic valvular disease, multiple embolic phenomena are rare.</AbstractText>To present a patient with rheumatic heart disease associated with multiple embolic complications.</AbstractText>A 44-year-old lady with rheumatic valvular disease and atria...
5,644
Early atropine is safer than conventional atropine administration in the elderly undergoing dobutamine stress echocardiography.
Early injection of atropine during dobutamine stress echocardiography has been demonstrated in retrospective analyses to reduce the duration and dose of dobutamine infusion, while preserving a similar diagnostic accuracy with a lower incidence of adverse effects.</AbstractText>In our prospective study, we sought to exp...
5,645
Safety baseballs and chest protectors: a systematic review on the prevention of commotio cordis.
To determine whether chest protectors and/or safety baseballs reduce the incidence of commotio cordis during sport through a review of the best available evidence.</AbstractText>PubMed, Ovid Medline, and Embase databases from 1950 to 2009. We selected articles according to "death, sudden, cardiac," "commotio cordis," "...
5,646
Relationship of functional mitral regurgitation to new-onset atrial fibrillation in acute myocardial infarction.
<AbstractText Label="BACKGROUND/OBJECTIVE" NlmCategory="OBJECTIVE">The role of factors that increase left atrial pressure or cause acute left atrial dilatation is frequently emphasised in the pathogenesis of atrial fibrillation (AF) in patients with acute myocardial infarction (AMI). This study was designed to test the...
5,647
Ouabain attenuates cardiotoxicity induced by other cardiac steroids.
All cardiac steroids have a similar structure, bind to and inhibit the ubiquitous transmembrane protein Na(+), K(+)-ATPase and increase the force of contraction of heart muscle. However, there are diverse biological responses to different cardiac steroids both at the cellular and at the molecular level. Moreover, we ha...
5,648
[Hundred years of atrial fibrillation: current knowledge and perspectives].
Atrial fibrillation (AF) is the most common sustained arrhythmia in general population. AF in humans was first described in 1903. Gradually, it has been well appreciated that AF is notjust an acceptable alternative for normal rhythm but rather a serious threat, related to increased mortality and cardiovascular morbidit...
5,649
Implementing the 2005 American Heart Association Guidelines improves outcomes after out-of-hospital cardiac arrest.
The purpose of the study was to determine whether applying highly recommended changes in the 2005 American Heart Association (AHA) Guidelines would improve outcomes after out-of-hospital cardiac arrest.</AbstractText>In 2005, AHA recommended multiple ways to improve circulation during cardiopulmonary resuscitation (CPR...
5,650
Dronedarone: an emerging therapy for atrial fibrillation.
Atrial fibrillation (AF) is a common arrhythmia, with a prevalence ranging from 0.1% to 9.0% at different ages, and is associated with increased cardiovascular events and mortality. A significant increase in the prevalence of the disease is expected to occur in the coming years as a consequence of the aging of the popu...
5,651
Sudden death due to isolated right ventricular infarction: a case report.
Isolated right ventricular infarction (RVI) is a rare phenomenon associated with atherosclerotic disease of the acute marginal vessels or of a non-dominant right coronary artery. It may happen in the absence of coronary disease when substantial right ventricular hypertrophy is present. The prognosis is usually good, al...
5,652
Circadian variation of human ventricular fibrillation dominant frequency.
Circadian variation in human ventricular fibrillation (VF) dominant frequency is unknown. If present this would provide evidence of physiological influence on VF. The objective was to quantify the circadian variation in human VF dominant frequency.</AbstractText>Eight-lead Holter ECG recordings were obtained from a pat...
5,653
The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram.
The spatial QRS-T angle (SA), a predictor of sudden cardiac death, is a vectorcardiographic variable. Gold standard vertorcardiograms (VCGs) are recorded by using the Frank electrode positions. However, with the commonly available 12-lead ECG, VCGs must be synthesized by matrix multiplication (inverse Dower matrix/Kors...
5,654
Nifekalant hydrochloride terminated electrical storms after coronary surgery.
An "electrical storm" is a life-threatening condition defined as a recurrent attack of ventricular tachycardia or fibrillation. The current report is a case study of a patient who had electrical storms developing unexpectedly after undergoing coronary artery bypass grafting. The electrical storms were terminated dramat...
5,655
A high-fidelity simulation mannequin to introduce pharmacy students to advanced cardiovascular life support.
To design and implement an advanced cardiac life support (ACLS) workshop featuring a human patient simulator (HPS) for third-year pharmacy students.</AbstractText>The ACLS workshop consisted of a pre-session lecture, a calculation exercise, and a 40-minute ACLS session using an HPS. Twenty-four 5-member teams of studen...
5,656
Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Heart Failure) study.
We sought to determine the utility of combined heart failure (HF) device diagnostic information to predict clinical deterioration of HF in patients with systolic left ventricular dysfunction.</AbstractText>Some implantable devices continuously monitor HF device diagnostic information, but data are limited on the abilit...
5,657
Successful resuscitation after prolonged periods of cardiac arrest: a new field in cardiac surgery.
Cardiopulmonary resuscitation is associated with high mortality and poor neurological recovery. Cardiopulmonary resuscitation can cause ischemia-reperfusion injury of the whole body and brain. We assessed the hypothesis that controlled reperfusion of the whole body with cardiopulmonary bypass would limit reperfusion in...
5,658
Does the E/e' index predict the maintenance of sinus rhythm after catheter ablation of atrial fibrillation?
The role of left ventricular (LV) diastolic dysfunction in recurrent atrial fibrillation (AF) after catheter ablation remains unknown. We investigated LV diastolic function using the ratio of early transmitral flow velocity (E) to early diastolic mitral annular velocity (e') and evaluated its predictive value for AF re...
5,659
Severe obstructive sleep apnea elicits concentric left ventricular geometry.
Obstructive sleep apnea (OSA) has several negative effects on the heart including increase in myocardial end-systolic stress, venous return and sympathetic activity, all potential stimuli of left ventricular (LV) hypertrophy. The impact of the severity of OSA on LV geometry is unknown. We hypothesized that OSA is relat...
5,660
ECG spectral and morphological parameters reviewed and updated to detect adult and paediatric life-threatening arrhythmia.
Since the International Liaison Committee on Resuscitation approved the use of automated external defibrillators (AEDs) in children, efforts have been made to adapt AED algorithms designed for adult patients to detect paediatric ventricular arrhythmias accurately. In this study, we assess the performance of two spectra...
5,661
Rationale and design of the NAGOYA HEART Study: comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance.
Inhibitors of the renin angiotensin system are recommended as the first-line medications for diabetic hypertensive patients. However, there is less evidence supporting this recommendation especially among East Asians, a population with a unique distribution of cardiovascular disease compared to the Western population.<...
5,662
Effects of electric stimulations applied during absolute refractory period on cardiac function of rabbits with heart failure.
The effects of electric currents applied during absolute refractory period (ARP) on the cardiac function of rabbits with heart failure due to myocardial infarction (MI), and the safety of this method were investigated. Thirty rabbits were randomly assigned equally to 3 groups: sham-operated group, LV-anterior wall card...
5,663
Applications of control theory to the dynamics and propagation of cardiac action potentials.
Sudden cardiac arrest is a widespread cause of death in the industrialized world. Most cases of sudden cardiac arrest are due to ventricular fibrillation (VF), a lethal cardiac arrhythmia. Electrophysiological abnormalities such as alternans (a beat-to-beat alternation in action potential duration) and conduction block...
5,664
The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence.
Recent clinical studies show that hypoglycaemia is associated with increased risk of death, especially in patients with coronary artery disease or acute myocardial infarction. This paper reviews data from cellular and clinical research supporting the hypothesis that acute hypoglycaemia increases the risk of malignant v...
5,665
Atrial fibrillation management strategies and early mortality after myocardial infarction: results from the Valsartan in Acute Myocardial Infarction (VALIANT) Trial.
The management of patients with atrial fibrillation (AF) following a myocardial infarction (MI) remains uncertain. This study compared a rate control strategy to an anti-arrhythmic-based rhythm control strategy for the treatment of AF following myocardial infarction.</AbstractText><AbstractText Label="DESIGN, SETTING A...
5,666
Risk factors for appropriate cardioverter-defibrillator shocks, inappropriate cardioverter-defibrillator shocks, and time to mortality in 549 patients with heart failure.
We investigated the risk factors for appropriate and inappropriate implantable cardioverter-defibrillator (ICD) shocks and mortality in 549 patients (mean age 74 years) with heart failure and ICDs. During a mean follow-up of 1,243 + or - 655 days, of the 549 patients, 163 (30%) had appropriate ICD shocks, 71 (13%) had ...
5,667
Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients.
Neuron specific enolase (NSE) has been proven effective in predicting neurological outcome after cardiac arrest with a current cut off recommendation of 33 microg/l. However, most of the corresponding studies were conducted before the introduction of mild therapeutic hypothermia (MTH). Therefore we conducted a study in...
5,668
Impact of Subxiphoid Video Pericardioscopy with a Rigid Shaft on Cardiac Hemodynamics in a Porcine Model.
OBJECTIVE: Single-port subxiphoid videopericardioscopy with a rigid shaft is useful for left atrial exclusion, left ventricular pacing lead implantation, and epicardial mapping, but it may interfere with the cardiac rhythm and adversely alter hemodynamics. We examined the impact of this technique on hemodynamic indices...
5,669
Isolation of pulmonary vein and superior vena cava for paroxysmal atrial fibrillation in a young adult with left ventricular non-compaction.
We report a 19-year-old male patient with left ventricular non-compaction who presented with atrial fibrillation (AF) and ventricular tachycardia. Ventricular tachycardia was induced by AF with rapid ventricular response, but was prevented by electrical isolation of the pulmonary veins and superior vena cava.
5,670
Atrial asynchrony and function before and after electrical cardioversion for persistent atrial fibrillation.
The relation between left atrial (LA) electrical and mechanical activity is a challenging field of investigation. The availability of echocardiographic strain analysis techniques has enhanced our ability to non-invasively assess LA wall mechanical synchrony and performance. The aim of our study was to investigate how n...
5,671
Electromechanical wavebreak in a model of the human left ventricle.
In the present report, we introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model ...
5,672
Minimizing pre- and post-defibrillation pauses increases the likelihood of return of spontaneous circulation (ROSC).
The three-phase model of ventricular fibrillation (VF) arrest suggests a period of compressions to "prime" the heart prior to defibrillation attempts. In addition, post-shock compressions may increase the likelihood of return of spontaneous circulation (ROSC). The optimal intervals for shock delivery following cessatio...
5,673
[Safety analyses from 439 patients underwent endomyocardial biopsy via the right internal jugular vein approach].
Primary indications for endomyocardial biopsy (EMB) include heart transplant rejection surveillance and identifying cardiomyopathy or myocarditis. EMB procedures have not yet gained widespread acceptance because of concerns about possible complications associated with EMB procedures. In this single-center retrospective...
5,674
[Association between metabolic syndrome and incidence of atrial fibrillation in essential hypertensive patients without left ventricular hypertrophy].
To investigate the association between metabolic syndrome (MS) and the incidence of atrial fibrillation (AF) in essential hypertensive (EH) patients without left ventricular hypertrophy.</AbstractText>A total of 972 EH without left ventricular hypertrophy were divided into EH + non MS group (n = 606) and EH + MS group ...
5,675
Favourable outcome after 26 minutes of "Compression only" resuscitation: a case report.
A 49 year old man had ventricular fibrillation in his home, at room temperature, due to an ST-elevation myocardial infarction. He received Cardiac compression only resuscitation (CC-only) for 26 minutes by his wife, followed by four minutes of standard CPR by other lay persons until EMS-arrival. Gasping and moaning wer...
5,676
Impact of dronedarone in atrial fibrillation and flutter on stroke reduction.
Dronedarone has been developed for treatment of atrial fibrillation (AF) or atrial flutter (AFL). It is an amiodarone analogue but noniodinized and without the same adverse effects as amiodarone.</AbstractText>This is a review of 7 studies (DAFNE, ADONIS, EURIDIS, ATHENA, ANDROMEDA, ERATO and DIONYSOS) on dronedarone f...
5,677
First experience of percutaneous radio-frequency ablation for atrial flutter and atrial fibrillation in a patient with HeartMate II left ventricular assist device.
We report the first case of percutaneous radio-frequency (RF) ablation procedure in a patient implanted with a HeartMate II left ventricular assist device for refractory heart failure. This procedure was performed for poorly tolerated recurrent atrial arrhythmias. No harmful consequence happened during or after the pro...
5,678
QRS duration and echocardiographic evidence of left ventricular dyssynchrony in patients with left ventricular systolic dysfunction.
To determine the association between left ventricular (LV) dyssynchrony assessed by tissue Doppler imaging (TDI) in patients with left ventricular ejection fraction (LVEF) &lt; 35% and prolonged ventricular depolarization on electrocardiography.</AbstractText>A cross-sectional study.</AbstractText>The Aga Khan Universi...
5,679
Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice.
Desmin mutations in humans cause desmin-related cardiomyopathy, resulting in heart failure, atrial and ventricular arrhythmias, and sudden cardiac death. The intermediate filament desmin is strongly expressed in striated muscle cells and in Purkinje fibers of the ventricular conduction system. The aim of the present st...
5,680
Predictors of ventricular tachyarrhythmia in high-risk myocardial infarction patients treated with primary coronary intervention.
Background. We investigated the association between clinical characteristics, angiographic data and ventricular arrhythmia in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI)Methods. In patients with STEMI (n=225), a Holter analysis was performed the...
5,681
Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy.
To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function.</AbstractText>A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM patients with L...
5,682
Acute effects of urocortin 2 on cardiac function and propensity for arrhythmias in an animal model of hypertension-induced left ventricular hypertrophy and heart failure.
To test acute effects of the corticotropin-releasing factor-related peptide urocortin 2 (Ucn2) on left ventricular (LV) function and the propensity for ventricular arrhythmias in the isolated heart of an animal model of hypertension-induced heart failure.</AbstractText>Hearts from Dahl salt-sensitive rats with severe L...
5,683
Neurologically intact survival in a porcine model of cardiac arrest: manual cardiopulmonary resuscitation vs. LifeBelt cardiopulmonary resuscitation.
To compare the LifeBelt (Deca-Medica, Inc., Columbus, OH), a novel cardiopulmonary resuscitation (CPR) device, with manual CPR on the outcome of neurologically intact survival in a porcine model of cardiac arrest.</AbstractText>Twenty-two adolescent swine were randomized by permuted block design to resuscitation using ...
5,684
Biatrial pacing vs. intravenous amiodarone in prevention of atrial fibrillation after coronary artery bypass surgery.
This study was aimed to compare the results of post operative biatrial pacing and i.v. amiodarone in prevention of AF. In a single blind randomized clinical trial, 210 patients scheduled for elective CABG surgery were randomized either to receive overdrive biatrial pacing, i.v. amiodarone or no intervention. Incidence ...
5,685
[Surgical outcomes of arrhythmia surgery associated with total cavo-pulmonary connection conversion for failed Fontan].
The occurrence of late-onset supraventricular tachyarrhythmia is one of the major factors for Fontan failure. In 1999, we initiated the arrhythmia surgery with combined total cavo-pulmonary connection (TCPC) conversion for failed Fontan patients.</AbstractText>From 1999 to 2008, a total of 7 patients (5 males) underwen...
5,686
AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog.
Recent development of drugs for the treatment of atrial fibrillation (AF) has focused on atrial selective agents. We examined the atrioventricular differences in sodium channel block of the antiarrhythmic agent AZD1305 in atria and ventricles of anesthetized dogs in vivo, canine isolated arterially perfused preparation...
5,687
Electrophysiologic characteristics and topographic distribution of focal atrial tachycardias in dogs.
Focal atrial tachycardia (FAT) is a common supraventricular tachycardia in dogs.</AbstractText>To evaluate electrophysiologic characteristics and topographic distribution of FAT.</AbstractText>Sixteen dogs with symptomatic FAT.</AbstractText>Retrospective case series. Electrophysiological studies were performed to test...
5,688
Too long or too short? New insights into abnormal cardiac repolarization in people with chronic epilepsy and its potential role in sudden unexpected death.
Sudden unexpected death in epilepsy (SUDEP) is probably caused by periictal cardiorespiratory alterations such as central apnea, bradyarrhythmia, and neurogenic pulmonary edema. These alterations may occur in people with epilepsy and vary in duration and severity. Seizure-related ventricular tachyarrhythmias have also ...
5,689
Concealed automaticity from an island of atrial myocardium post cavotricuspid ablation.
We report the case of a patient with paroxysmal atrial fibrillation in whom 2 previous cavotricuspid isthmus (CTI) ablations were performed for recurrent type I counterclockwise atrial flutter. One year after the last CTI ablation, the patient underwent pulmonary vein isolation for AF and reassessment of conduction blo...
5,690
Regional variations in action potential alternans in isolated murine Scn5a (+/-) hearts during dynamic pacing.
clinical observations suggest that alternans in action potential (AP) characteristics presages breakdown of normal ordered cardiac electrical activity culminating in ventricular arrhythmogenesis. We compared such temporal nonuniformities in monophasic action potential (MAP) waveforms in left (LV) and right ventricular ...
5,691
An unexpected diagnosis: simulation reveals unanticipated deficiencies in resident physician dysrhythmia knowledge.
Decision support tools are an important adjunct to medical resuscitation. We initiated a study comparing the use of the traditional code book method versus a computerized decision support system. However, appropriate use of the tools requires correct initial recognition of the dysrhythmia. Using simulation, numerous de...
5,692
Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts.
Little is known about the three-dimensional (3-D) intramural activation sequences during long-duration ventricular fibrillation (VF), including the role of the subendocardium and its Purkinje fibers (PFs) in long-duration VF maintenance. Our aim was to explore the mechanism of long-duration VF maintenance with 3-D elec...
5,693
Association between renin-angiotensin-aldosterone system blockers and postoperative atrial fibrillation in patients with mild and moderate left ventricular dysfunction.
The aim of the study was to evaluate the association between renin - angiotensin - aldosterone system blockers and risk of postoperative atrial fibrillation (AF) development in patients with mild and moderate left ventricular systolic dysfunction.</AbstractText>The population of this prospective and observational study...
5,694
[Retrospective analysis of 1650 permanent pacemaker implantations experience over two different consecutive time periods in a single cardiology clinic].
Indications for pacing, pacing modes, and demographics of patients who underwent pacemaker implantation between two different time periods were compared in this study.</AbstractText>Pacemaker registry of our cardiology department was used to evaluate these changes from 1986 to 2007 (First period: 1986-1996, second peri...
5,695
Pacemaker/implantable cardioverter-defibrillator interaction.
We describe a case of pacemaker/implantable cardioverter-defibrillator (ICD) interaction in a single system causing failure to detect induced ventricular fibrillation (VF) in an 83-year-old man with ischemic cardiomyopathy. He underwent an ICD generator replacement due to battery depletion. In addition, a right atrial ...
5,696
What can be done when asymptomatic patients discover they have Brugada syndrome? A case report of Brugada syndrome.
Brugada syndrome is an inherited cardiac disorder associated with a specific electrocardiographic pattern, involving ST segment elevation in leads V1 to V3. When not spontaneously terminated, it can lead to ventricular fibrillation and sudden death. We present a case report of a young male whose brother suffered a sudd...
5,697
Connexin-43 redistribution and gap junction activation during forced restraint protects against sudden arrhythmic death in rats.
Connexin-43 (Cx43) expression is reduced or redistributed in heart disease. Restraint or other emotional stressors might cause sudden death in persons with such diseases, but the mechanism of death and its connection to Cx43 during restraint remain unknown. Whether Cx43 distribution or gap junction (GJ) function during...
5,698
Feasibility of cardiac resynchronization therapy in a patient with complex congenital heart disease and dextrocardia, facilitated by cardiac computed tomography and coronary sinus venography.
We describe a case with pacemaker implantation for cardiac resynchronization therapy (CRT) in a patient with complex congenital heart disease, facilitated by cardiac computed tomography (CT) and coronary sinus (CS) venography. A 37-year-old male presented with congenitally corrected transposition of the great arteries ...
5,699
Etiology and outcome of cardioembolic stroke in young adults in Greece.
Cardioembolism is the most frequent cause of ischemic stroke in Greece. However, data regarding this stroke subtype in young adults from Greece and the East Mediterranean area are scarce.</AbstractText>We aimed to determine the source of embolism and evaluate outcomes in a sample of young Greek patients with ischemic s...