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5,700
Can sudden cardiac death be prevented?
Hypertrophic cardiomyopathy is regarded as the most common cause of sudden cardiac death in young people (including trained athletes). Introduction of implantable cardioverter-defibrillators to the hypertrophic cardiomyopathy patient population represents a new paradigm for clinical practice and perhaps the most signif...
5,701
Failure in short-term prediction of ventricular tachycardia and ventricular fibrillation from continuous electrocardiogram in intensive care unit patients.
Patients in the intensive care unit (ICU) setting are prone to malignant ventricular arrhythmias. We sought to test whether electrocardiographic (ECG) markers of autonomic tone, ventricular irritability, and repolarization lability could be used in short-term prediction of ventricular arrhythmias in this patient popula...
5,702
Exercise capacity is the most powerful predictor of 2-year mortality in patients with left ventricular systolic dysfunction.
There are few data about predictors of cardiovascular mortality and rehospitalization rate in patients with left ventricular systolic dysfunction (LVSD) after myocardial revascularization and optimization of pharmacological treatment.</AbstractText>1,346 consecutive patients with left ventricular ejection fraction (LVE...
5,703
Development of malignant ventricular arrhythmias in a young male with WPW pattern.
In Wolff-Parkinson-White Syndrome (WPW), presence of accessory pathways causes various tachyarrhythmias that lead to different symptoms and clinical conditions in patients. Atrial fibrillation is observed in about 20-30% of this group of patients. Life threatening malignant ventricular arrhythmias and sudden cardiac de...
5,704
Factors likely to affect the long-term results of ventricular stimulation after myocardial infarction.
The results of programmed ventricular stimulation (PVS) may change after myocardial infarction (MI). The objective was to study the factors that could predict the results of a second PVS.</AbstractText>Left ventricular ejection fraction (LVEF) and QRS duration were determined and PVS performed within 3 to 14 years of o...
5,705
[Life-support training to improve the clinical competence of pharmacy students].
Life-support (particularly, advanced life-support) training is not included in pharmacist education; however, the life-support should be mastered since a pharmacist is a medical professional. We consider it to be important to master other skills before the life-support practicing, because a pharmacist does not check a ...
5,706
A comprehensive investigation of cardiac arrest before and after arrival of emergency medical services.
Many of the factors that affect survival from out-of-hospital cardiac arrest are not relevant in patients who arrest after arrival of emergency medical services (EMS). Because all arrests that occur after arrival of EMS are witnessed and care is immediate, one might expect survival to be very high. Several studies have...
5,707
Antidromic His capture during entrainment of orthodromic AVRT.
A narrow QRS tachycardia with eccentric atrial activation is presented with features favoring an orthodromic atrioventricular re-entrant tachycardia including an extranodal paraHisian response, and a short corrected post-pacing interval to tachycardia cycle length difference following right ventricular entrainment. How...
5,708
Intrathoracic impedance preceding ventricular tachyarrhythmia episodes.
Heart failure is associated with ventricular tachyarrhythmias (VT/VF). Fluid accumulation during worsened heart failure may trigger VT/VF. Increased intrathoracic impedance has been correlated with fluid accumulation during heart failure. Implanted defibrillators capable of daily measures of intrathoracic impedance all...
5,709
Effect of an electronic control device exposure on a methamphetamine-intoxicated animal model.
Because of the prevalence of methamphetamine abuse worldwide, it is not uncommon for subjects in law enforcement encounters to be methamphetamine-intoxicated. Methamphetamine has been present in arrest-related death cases in which an electronic control device (ECD) was used. The primary purpose of this study was to det...
5,710
Out-of-hospital cardiac arrest in denver, colorado: epidemiology and outcomes.
The annual incidence of out-of-hospital cardiac arrest (OOHCA) in the United States is approximately 6 per 10,000 population and survival remains low. Relatively little is known about the performance characteristics of a two-tiered emergency medical services (EMS) system split between fire-based basic life support (BLS...
5,711
Cardiocerebral resuscitation is associated with improved survival and neurologic outcome from out-of-hospital cardiac arrest in elders.
Recent studies have shown that a new emergency medical services (EMS) protocol for treating patients who suffer out-of-hospital cardiac arrest (OHCA), cardiocerebral resuscitation (CCR), significantly improves survival compared to standard advanced life support (ALS). However, due to their different physiology, it is u...
5,712
An unusual presentation of primary renal hypokalemia-hypomagnesemia (Gitelman's syndrome).
Gitelman's syndrome, or congenital hypokalemic hypomagnesemic hypocalciuria with metabolic alkalosis, is widely described as a benign or milder variant of Bartter's syndrome and most commonly presents with transient periods of weakness and fatigue, presyncope, vertigo, ataxia, and blurred vision, though aborted sudden ...
5,713
Left atrial volume combined with atrial pump function identifies hypertensive patients with a history of paroxysmal atrial fibrillation.
Identifying patients at high risk for the occurrence of atrial fibrillation is one means by which subsequent thromboembolic complications may be prevented. Left atrial enlargement is associated with progression of atrial remodeling, which is a substrate for atrial fibrillation, but impaired atrial pump function is also...
5,714
Phase statistics approach to human ventricular fibrillation.
Ventricular fibrillation (VF) is known to be the most dangerous cardiac arrhythmia, frequently leading to sudden cardiac death (SCD). During VF, cardiac output drops to nil and, unless the fibrillation is promptly halted, death usually ensues within minutes. While delivering life saving electrical shocks is a method of...
5,715
Atrium-targeted drug delivery through an amiodarone-eluting bilayered patch.
Clinical studies have demonstrated the efficacy of oral and intravenous amiodarone therapy to prevent postoperative atrial fibrillation. However, because of significant extracardiac side effects, only high-risk patients are eligible for prophylactic amiodarone therapy. This study addressed the hypothesis that atrium-sp...
5,716
Long-term outcome of combined valve repair and maze procedure for nonrheumatic mitral regurgitation.
The long-term outcomes of combined mitral repair and maze procedure for patients with nonrheumatic mitral regurgitation and chronic atrial fibrillation were evaluated.</AbstractText>Between June 1992 and December 2008, 187 patients underwent a combined mitral repair and maze procedure. The mean follow-up period was 7.4...
5,717
Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation.
Familial recurrence of atrial fibrillation (AF) is reported in up to 15% of patients with lone AF. Recently, it was proposed that congenital defects in the morphogenesis of the pulmonary vein myocardium are involved in genetic pathogenesis of lone AF. GATA4 is a cardiac transcription factor essentially involved in myoc...
5,718
Electronic health records and quality of care for heart failure.
Electronic health records (EHRs) are considered an important technology to improve the quality of health care, yet few data exist regarding their effect on delivery of evidence-based care in the outpatient setting.</AbstractText>IMPROVE HF is a prospective cohort study of 15,381 patients with HF or post myocardial infa...
5,719
Improved out-of-hospital cardiac arrest survival after the sequential implementation of 2005 AHA guidelines for compressions, ventilations, and induced hypothermia: the Wake County experience.
We assess survival from out-of-hospital cardiac arrest after community-wide implementation of 2005 American Heart Association guidelines.</AbstractText>This was an observational multiphase before-after cohort in an urban/suburban community (population 840,000) with existing advanced life support. Included were all adul...
5,720
Zoledronic acid and atrial fibrillation in cancer patients.
Treatment with a bisphosphonate was found to be associated with a significantly increased risk for atrial fibrillation (AF) in a few studies. A recent study showed that once-yearly infusions of intravenous zoledronic acid (ZA) significantly increased the risk of serious AF in postmenopausal women with osteoporosis. Thi...
5,721
Catheter ablation of a difficult accessory pathway guided by coronary sinus venography and 3D electroanatomical mapping.
A 38-year-old man with history of unsuccessful catheter ablation of paraseptal accessory pathway (AP) and cardiac arrest was referred for reablation. Coronary sinus (CS) venography and detailed three-dimensional electroanatomical mapping demonstrated a large diverticulum near the CS ostium. A single radiofrequency abla...
5,722
[The echocardiographic diagnostic characteristics and follow-up of apical hypertrophic cardiomyopathy.].
To evaluate the echocardiographic features of apical hypertrophic cardiomyopathy (ApHCM).</AbstractText>Twenty-seven patients with ApHCM including 21 men and 6 women, average age (42.7 +/- 5.1) years old were followed up from 1995 to 2008 to investigate the clinical, electrocardiographic and echocardiographic features....
5,723
Importance of morphological changes in T-U waves during bepridil therapy as a predictor of ventricular arrhythmic event.
Although bepridil is a useful anti-arrhythmic agent for atrial fibrillation, the appearance of serious ventricular arrhythmia, such as torsades de pointes, might be a problem. In this study, T-U wave morphology was evaluated during bepridil therapy and was examined as a predictor of ventricular arrhythmic events.</Abst...
5,724
Acute toxic herbal intake in a suicide attempt and fatal refractory ventricular arrhythmia.
This report involves a 54-year-old man who died following refractory ventricular fibrillation after ingestion of a plant in a suicide attempt. Repeated direct-current cardioversions were unsuccessful and no single anti-arrhythmic agent was effective for arrhythmia control. The routine blood toxicological screening was ...
5,725
Digitalis does not improve left atrial mechanical dysfunction after successful electrical cardioversion of chronic atrial fibrillation.
This study was designed to investigate whether administration of digitalis could improve mechanical function of left atrial appendage (LAA) and left atrium prospectively in patients with atrial stunning. Fifty-four consecutive patients in whom atrial stunning was observed immediately after cardioversion of chronic atri...
5,726
Comparison of thiopental, urethane, and pentobarbital in the study of experimental cardiology in rats in vivo.
Despite earlier research studying the influence of anesthetics in arrhythmia models, a lot of controversy remains. The aim was to compare the influence of three anesthetics (60 mg/kg thiopental, 1200 mg/kg urethane, 60 mg/kg pentobarbital intraperitoneally) on ventricular arrhythmias and to combine it with measured hem...
5,727
DEFI 2005: a randomized controlled trial of the effect of automated external defibrillator cardiopulmonary resuscitation protocol on outcome from out-of-hospital cardiac arrest.
Using automated external defibrillators (AEDs) that implement the Guidelines 2000 resuscitation protocol constrains administration of cardiopulmonary resuscitation (CPR) to &lt;50% of AED connection time. We tested a different AED protocol aimed at increasing the CPR administered to patients with out-of-hospital cardia...
5,728
Progression of preclinical diastolic dysfunction to the development of symptoms.
Preclinical diastolic dysfunction (PDD) has been defined as subjects with normal systolic function, diastolic dysfunction but no symptoms of heart failure (HF). The clinical phenotype and natural history of the syndrome remains poorly defined. This study's objective was to determine the clinical phenotype and progressi...
5,729
A novel cardiac myosin-binding protein C S297X mutation in hypertrophic cardiomyopathy.
Mutations in the cardiac myosin-binding protein C gene (MYBPC3) have been reported to be associated with delayed expression of hypertrophic cardiomyopathy (HCM) and a relatively good prognosis.</AbstractText>The aim of this study was to evaluate clinical manifestations in patients with familial HCM caused by a novel no...
5,730
What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease?
The purpose of our study was to determine what variables were associated with ventricular fibrillation (VF) induced during electrophysiological stimulation test in patients without apparent organic heart disease.</AbstractText>Our study evaluated 77 patients (51+/-15 years) who underwent electrophysiological stimulatio...
5,731
Bioprosthetic mitral valve thrombosis less than one year after replacement and an ablative MAZE procedure: a case report.
Occurrence of bioprosthetic valve thrombosis less than a year after replacement is very uncommon. Here, we describe a case of a 57 year old male, who presented 10 months after receiving a bioprosthetic mitral valve replacement with a two week history of dyspnea on exertion, worsening orthopnea and decreased exercise to...
5,732
Extracorporeal membrane oxygenation as a "bridge to recovery" in a case of myotomy for myocardial bridge complicated by biventricular dysfunction.
The incidence of cardiac dysfunction after routine cardiac surgical procedures is quite high (3-5%), but the majority of patients improve using inotropic drugs or intraaortic balloon counterpulsation. However, approximately 1% of these patients do not benefit from using these supports, and they need more invasive strat...
5,733
Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric window.
After near-defibrillation threshold (DFT) shocks from an implantable cardioverter-defibrillator (ICD), the first postshock activation that leads to defibrillation failure arises focally after an isoelectric window (IW). The mechanisms underlying the IW remain incompletely understood.</AbstractText>The goal of this stud...
5,734
Feasibility of in vivo transesophageal cardiac ablation using a phased ultrasound array.
Over 2.2 million Americans suffer from atrial fibrillation making it one of the most common arrhythmias. Cardiac ablation has shown a high rate of success in treating paroxysmal atrial fibrillation. Prevailing modalities for this treatment are catheter based radio-frequency ablation or surgery. However, there is measur...
5,735
Isolated left ventricular noncompaction: a small, noncompacted segment may cause serious complications.
Isolated left ventricular noncompaction is a rare form of cardiomyopathy. Heart failure with deteriorated systolic function is the hallmark of this cardiomyopathy. Albeit it may cause ventricular tachycardia (VT) and systemic embolism, it is a rarity to see these complications in a patient with noncompaction and normal...
5,736
Glucagon-like peptide-1 (GLP-1) attenuates post-resuscitation myocardial microcirculatory dysfunction.
Post-resuscitation syndrome leads to death in approximately 2 out of every 3 successfully resuscitated victims, and myocardial microcirculatory dysfunction is a major component of this syndrome. The aim of this study was to determine if glucagon-like peptide-1 (GLP-1) improves post-resuscitation myocardial microcircula...
5,737
Extending the use of the pacing pulmonary artery catheter for safe minimally invasive cardiac surgery.
In this study, the therapeutic use of pacing pulmonary artery catheters in association with minimally invasive cardiac surgery was evaluated.</AbstractText>A retrospective study.</AbstractText>A single institutional university hospital.</AbstractText>Two hundred twenty-four consecutive patients undergoing minimally inv...
5,738
The optimal phasic relationship between synchronized shock and mechanical chest compressions.
Pauses for shock delivery in chest compressions are detrimental to the success of resuscitation and may be eliminated with the use of mechanical chest compressors. However, the optimal phasic relationship between mechanical chest compression and defibrillation is still unknown. We therefore undertook a study to assess ...
5,739
Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system.
We examined the impact of acute myocardial ischemia followed by reperfusion (AMI-R) on local and circulating renin-angiotensin system (RAS) in a swine model. The mid left anterior descending artery (n = 6) was occluded for 1 h, followed by reperfusion for 2 h. Monastryl blue/triphenyl tetrazolium chloride staining iden...
5,740
Gender difference in arrhythmic occurrences in patients with nonischemic dilated cardiomyopathy and implantable cardioverter-defibrillator.
Previous studies indicated that women were less likely to experience ventricular arrhythmia recurrence than men among patients with coronary artery disease and implantable cardioverter defibrillator (ICD). However, it is not clear whether the risk for ventricular tachyarrhythmia is gender-dependent in patients with non...
5,741
Permanent His-bundle pacing: seeking physiological ventricular pacing.
Right ventricular apical pacing can have deleterious effects and the His bundle has been widely reported to be an alternative site. This paper presents our experience with permanent His-bundle pacing (HBP).</AbstractText>Patients referred for pacemaker implants (regardless of block type) were screened to determine if t...
5,742
Long-term survival of routine implantable cardioverter/defibrillator recipients appears to be significantly impaired with concomitant diuretics and improved with aldosterone antagonists.
Evidence-based treatment for heart failure (HF) comprises beta-blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone receptor antagonists (ARA). Diuretics (DR) are prescribed in acute and chronic HF, but their impact on survival and ventricular tachyarrhythmias (VT/VF) is un...
5,743
[Detection of ventricular tachycardia and ventricular fibrillation based on joint entropy].
This is a research with the aim of using joint entropy method to analyze the dynamical complexity information on the electrocardiogram signals recording of normal sinus rhythm (NSR), ventricular tachycardia (VT) and ventricular fibrillation (VF). We included the symbolic dynamical theory and surrogate data concept in i...
5,744
[Algorithm study on the three-dimensional cardiac tissue based on the model of ventricular action potential].
Cardiac reentry is one of the important factors to induce arrhythmias. It could lead to ventricular tachycardia (VT) or even fibrillation (VF), resulting in sudden cardiac death. With the wide use of computer in the quantitative study of electrophysiology, the three-dimensional virtual heart for simulations needs to be...
5,745
[Perioperative acquired long QT syndrome: a case report].
Acquired long QT syndrome is a rare condition whose diagnosis is of vital importance given the risk of torsade de pointes and sudden death. This syndrome may be triggered by various events in patients with a genetic predisposition. Patients usually have a normal baseline QT interval. Some of the factors that may prolon...
5,746
Intravenous levosimendan vs. dobutamine in acute decompensated heart failure patients on beta-blockers.
The aim of this study is to compare the effects of a 24 h intravenous infusion of levosimendan and a 48 h infusion of dobutamine on invasive haemodynamics in patients with acutely decompensated chronic NYHA class III-IV heart failure. All patients were receiving optimal oral therapy including a beta-blocker.</AbstractT...
5,747
New antiarrhythmic drugs for treatment of atrial fibrillation.
Inadequacies in current therapies for atrial fibrillation have made new drug development crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In drug development, the focus has been on favourable multichannel-blocking profiles, atrial-specific ion-channels, and novel non-channel ta...
5,748
Functional atrioventricular conduction block in an elderly patient with acquired long QT syndrome: elucidation of the mechanism of block.
The long QT syndrome (LQTS) is occasionally complicated by impaired atrioventricular (AV) conduction. This form of LQTS can manifest before birth or during neonatal life, and no previous report has demonstrated LQTS complicated by impaired AV conduction in elderly patient. This case report describes an elderly patient ...
5,749
[Adenosine induces ventricular arrythmias in hearts with chronic chagas cardiomyopathy].
Adenosine released during ischemia and hypoxia can induce ventricular arrhythmias. This phenomenon is also observed in Chagas disease. This study involved pharmacologic analysis of the arrhythmogenic properties of adenosine in healthy Sprague-Dawley rats (n=14) and in rats with chronic Chagas cardiomyopathy (n=14). Ele...
5,750
Long-term outcome of alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy: a word of caution.
The impact of alcohol septal ablation (ASA)-induced scar is not known. This study sought to examine the long-term outcome of ASA among patients with obstructive hypertrophic cardiomyopathy.</AbstractText>Ninety-one consecutive patients (aged 54+/-15 years) with obstructive hypertrophic cardiomyopathy underwent ASA. Pri...
5,751
Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers.
The regulatory guidelines (ICHS7B) for the identification of only drug-induced long QT and pro-arrhythmias have certain limitations.</AbstractText>Conduction time (CT) was measured in isolated Purkinje fibres, left ventricular perfused wedges and perfused hearts from rabbits, and sodium current was measured in Chinese ...
5,752
The late impact of surgical skills and training on the subcoronary implantation of the Freestyle stentless bioprosthesis.
Recent data have demonstrated an impact of higher postoperative mean pressure gradient (MPG) across the subcoronary Freestyle stentless bioprosthesis on the mid-term quality of life, but not on that of survival. Thus, the question remains that, with a prolonged follow up, would an effect on duration of survival also ev...
5,753
Elderly woman with cerebrovascular accident and refractory arrhythmias.
Fatal bilateral cerebro-vascular accident with variable atrio-ventricular blocks, atrial fibrillation and refractory tachy-arrhythmias in a previously healthy 75-years-old hypertensive female is presented.
5,754
[Stored electrograms in pacemakers and ICDs from St. Jude Medical].
Stored electrograms (EGMs) significantly improve pacemaker and ICD therapy. In pacemaker systems, the main focus of stored EGMs concerns the manual control of device detection of atrial tachyarrhythmias, especially atrial fibrillation. In ICD therapy, stored EGMs allow the discrimination of adequate and inadequate dete...
5,755
[Analysis of intracardial electrograms in pacemakers and ICD systems by Biotronik].
Detailed analysis of stored electrograms is essential for the interpretation of arrhythmias, programming changes, and optimization of the medical therapy in patients with implanted pacemakers and defibrillators. The physician who cares for patients with implantable electrical devices has to be able to understand the de...
5,756
Prevalence of preoperative arrhythmias in children with delayed treatment of severe congenital heart disease.
Our aim was to determine the real importance of rhythm and conduction disorders in children with unoperated severe congenital heart disease.</AbstractText>Consecutive children with delayed treatment of severe congenital heart disease were prospectively studied for the occurrence of arrhythmias before any invasive inves...
5,757
Mechanistic insights into initiation and maintenance of ventricular fibrillation: implications for catheter ablation.
This report is intended to provide an overview of the mechanism(s) of ventricular fibrillation (VF) and its relation to catheter ablation.</AbstractText>We conducted a Pubmed and Medline literature search to identify all experimental and clinical studies published in English involving the mechanisms of VF and catheter ...
5,758
Does the coronary disease increase the hospital mortality in patients with aortic stenosis undergoing valve replacement?
With the increase in life expectancy occurred in recent decades, it has been noted the concomitant increase in the prevalence of aortic stenosis and degenerative disease of atherosclerotic coronary artery. This study aims to evaluate the influence of atherosclerotic coronary artery disease in patients with critical aor...
5,759
Realistic expectations for public access defibrillation programs.
Public access defibrillation programs have increased dramatically over the past 15 years. This review will focus on their effectiveness and operational characteristics and discuss the characteristics of successful programs, which can improve outcomes.</AbstractText>Automated external defibrillators increase survival fr...
5,760
Mesothelial cells vs. skeletal myoblasts for myocardial infarction.
Cell transplantation for the regeneration of ischemic myocardium is limited by poor graft viability and low cell retention. Omental flaps in association with growth factors and cell sheets have recently been used to increase the vascularization of ischemic hearts. This experimental study was undertaken to evaluate the ...
5,761
Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy.
The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence of new-onset atrial fibrillation (AF) and cardiac events in patients with acute myocardial infarction (AMI) and left ventricular (LV) systolic dysfunction.</AbstractText>The study was performed as a substudy ...
5,762
Registration of 4D cardiac CT sequences under trajectory constraints with multichannel diffeomorphic demons.
We propose a framework for the nonlinear spatiotemporal registration of 4D time-series of images based on the Diffeomorphic Demons (DD) algorithm. In this framework, the 4D spatiotemporal registration is decoupled into a 4D temporal registration, defined as mapping physiological states, and a 4D spatial registration, d...
5,763
Impact of preoperative atrial fibrillation on the late outcome of off-pump coronary artery bypass surgery.
The impact of pre-existing atrial fibrillation on the long-term outcome in patients after off-pump coronary revascularisation is not well known. This study aims to determine the independent effects of preoperative atrial fibrillation on the early and late outcomes of off-pump coronary artery bypass surgery.</AbstractTe...
5,764
Primary isolated aortic valve surgery in octogenarians.
We reviewed our surgery registry, to identify predictive risk factors for operative results, and to analyse the long-term survival outcome in octogenarians operated for primary isolated aortic valve replacement (AVR).</AbstractText>A total of 124 consecutive octogenarians underwent open AVR from January 1990 to Decembe...
5,765
Validation of a cutoff value on echo Doppler analysis to replace right heart catheterization during pulmonary hypertension evaluation in heart transplant candidates.
Heart transplantation (OHT) has traditionally been contraindicated in the presence of severe pulmonary hypertension (PH), as detected by right heart catheterization. Noninvasive methods are still not reliably accurate to make this evaluation.</AbstractText>Determine the efficacy of echo Doppler analysis for the diagnos...
5,766
The clinical course of acute ST-elevation myocardial infarction in patients with hypertension.
Arterial hypertension has been documented as one the cardiovascular risk factors. The issue whether hypertension worsens the clinical course and short-term prognosis of patients with acute ST-elevation myocardial infarction (STEMI) has been addressed by several studies, however, the results were not uniform.</AbstractT...
5,767
Determinants of physical fitness in males with systolic heart failure.
Heart failure (HF) is a systemic disease which affects mainly older adults. The main symptom of HF is exercise intolerance which in the course of disease can cause limitations in independent functioning. So far no study on the impact of HF on physical fitness in men, regardless of disease severity, has been reported.</...
5,768
Atypical ST segment elevation and ventricular fibrillation without structural heart disease: a new electrocardiographic presentation of a channelopathy?
Primary electrical syndromes are a group of rare inherited diseases that predispose to arrhythmias in the absence of structural abnormalities of the heart, and are associated with several ion channel mutations. Extrinsic factors, such as fever, may contribute to the development of electrical instability in these patien...
5,769
Percutaneous mitral valve repair with the MitraClip system: acute results from a real world setting.
This study sought to evaluate the feasibility and early outcomes of a percutaneous edge-to-edge repair approach for mitral valve regurgitation with the MitraClip system (Evalve, Inc., Menlo Park, CA, USA). METHODS AND RESULTS PATIENTS: were selected for the procedure based on the consensus of a multidisciplinary team. ...
5,770
Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest.
The objective of this study was to compare the efficacy of terlipressin versus adrenaline in an experimental infant animal model of asphyxial cardiac arrest (ACA).</AbstractText>Prospective randomised animal study.</AbstractText>Laboratory research department of a university hospital.</AbstractText>Seventy-one, 2-month...
5,771
Nationwide public-access defibrillation in Japan.
It is unclear whether dissemination of automated external defibrillators (AEDs) in public places can improve the rate of survival among patients who have had an out-of-hospital cardiac arrest.</AbstractText>From January 1, 2005, through December 31, 2007, we conducted a prospective, population-based, observational stud...
5,772
QRS duration is associated with atrial fibrillation in patients with left ventricular dysfunction.
QRSduration (QRSd) is associated with higher mortality and morbidity in patients with left ventricular (LV) dysfunction. The association between QRSd and atrial fibrillation (AF) has not been studied in this patient population.</AbstractText>To investigate the association between QRSd and AF in patients with LV dysfunc...
5,773
TGF-beta1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease.
Atrial fibrosis was considered a structural basis for the development and sustaining of atrial fibrillation (AF). Transforming growth factor-beta1 (TGF-beta1) was one of the main factors for accelerating collagen production. The contribution of TGF-beta1 in the pathogenesis of AF needs further investigation.</AbstractT...
5,774
Attenuation of post-shock increases in brain natriuretic Peptide with post shock overdrive pacing.
Predischarge defibrillation threshold testing is often performed a few days after ICD implantation in order to validate defibrillation thresholds obtained at the time of implant. Ventricular fibrillation is induced with such testing and causes an increase in serum Brain Natriuretic Peptide (BNP) levels. BNP is an indic...
5,775
Effects of metabolic syndrome on early mortality and morbidity in coronary artery bypass graft patients.
Metabolic syndrome is a well-known cardiovascular risk factor closely related to increased insulin resistance. This study assessed the effects of metabolic syndrome on early post-operative mortality and morbidity in 100 coronary artery bypass graft (CABG) patients: 50 patients with and 50 without metabolic syndrome. A ...
5,776
Inappropriate shock despite successful termination of supraventricular tachycardia by antitachycardia pacing during charging.
We present a case of a 70-year-old man who received an inappropriate implantable cardioverter-defibrillator shock for sinus tachycardia falling outside of the ventricular tachycardia zone. This occurred after termination of supraventricular tachycardia falling into the ventricular fibrillation zone by antitachycardia p...
5,777
A phenotypic combination of idiopathic VF and Brugada syndrome.
This case study shows a young male presenting a mixture of two disease entities: (1) Brugada syndrome with a nearly-normal baseline electrocardiogram and positive Ajmaline drug challenge as well as (2) idiopathic ventricular fibrillation including extremely short-coupled monomorphic ventricular premature beats (VPB) tr...
5,778
Actual pacemaker longevity: the benefit of stimulation by automatic capture verification.
We evaluated the impact of an algorithm for automatic right ventricular (RV) stimulation compared to fixed-output pacing (FOP) stimulation on actual pacemaker longevity over a 9-year follow-up.</AbstractText>Prospective observation of 300 patients implanted with VDDR/DDDR pacemakers in 1999-2000 up to October 31, 2008....
5,779
[Stored electrograms in pacemakers and ICDs].
Stored electrograms (EGMs) represent an important development in pacemaker and ICD therapy. The most important issue in pacemaker EGMs is the confirmation of the detection of atrial tachyarrhythmias, especially atrial fibrillation. In ICD therapy, the discrimination between ventricular and supraventricular tachycardia ...
5,780
Sleep apnea in heart failure patients.
Growing evidence suggests that there may be a strong pathophysiologic link between congestive heart failure (CHF) and nocturnal breathing disorders due to nocturnal oxygen desaturation, intrathoracic pressure swings and sympathetic activation. It seems that sleep apnea contributes to systolic and diastolic heart failur...
5,781
[Atrioventricular synchrony in patients with pacemaker with VDD mode pacing. A 14-year descriptive study].
To analyze the performance of VDD mode pacing in patients with complete AV block with special attention on maintaining AV synchrony.</AbstractText>This is a descriptive, retrospective and observational study of a case series.</AbstractText>Intensive Medicine Department of a tertiary hospital.</AbstractText>All patients...
5,782
Cardiac resynchronization therapy after atrioventricular node ablation for rapid atrial fibrillation in a heart transplant recipient with late allograft dysfunction.
We report the successful use of cardiac resynchronization therapy in an orthotopic heart transplant recipient with late graft dysfunction, severe heart failure, and atrial fibrillation requiring atrioventricular node ablation. This case highlights the potential role for cardiac resynchronization therapy in orthotopic h...
5,783
Racial differences in atrial fibrillation prevalence and left atrial size.
Previous studies relying on clinical care data have suggested that atrial fibrillation is less common in African Americans than Caucasians, but the mechanism remains unknown. Clinical care may itself vary by race, potentially affecting the accuracy of atrial fibrillation ascertainment in studies relying on clinical dat...
5,784
Coronary blood flow and perfusion pressure during coronary angiography in patients with ongoing mechanical chest compression: a report on 6 cases.
Patients with pulseless electrical activity or refractory ventricular fibrillation have a very bad prognosis. Coronary angiography and angioplasty may be required to restore an effective circulation, but this must be performed whilst chest compressions are continued. The LUCAS chest compression device is suitable for t...
5,785
Neuromuscular and cardiac comorbidity determines survival in 140 patients with left ventricular hypertrabeculation/noncompaction.
The prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is controversial. We assessed cardiologic and neurologic predictors for mortality in LVHT patients and how many received implantable cardioverters/defibrillators(ICD) or cardiac resynchronization devices (CRT).</AbstractText>Include...
5,786
Asynchronous contraction of the 2 ventricles caused by ventricular pacing after a Fontan-type operation in a patient with a biventricular heart.
We treated a 6-year-old boy who had polysplenia syndrome and tetralogy of Fallot with a small right ventricle (RV), an atrial septal defect, a hemiazygos connection, and bilateral superior vena cava. Because the RV was too small for a biventricular repair to be performed, the patient underwent a total cavopulmonary shu...
5,787
Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
It has been shown that elevated heart rate identified patients with coronary artery disease and left ventricular dysfunction at increased risk of cardiovascular outcomes.</AbstractText>We sought to assess the prognostic impact of heart rate at presentation in patients with ST-elevation acute myocardial infarction (STEM...
5,788
Bentall procedure in ascending aortic aneurysm: hospital mortality.
Ascending aortic aneurysm disease (AAAD) shows a low frequency, heterogeneous behavior, high risk of rupture, dissection and mortality, making elective surgery necessary. Several procedures have been developed, and the Bentall technique is considered as the reference standard. The objective was to describe the hospital...
5,789
[The role of the accessory pathway radiofrequency catheter ablation in the secondary prevention of the malignant tachyarrhythmias in patients with Wolff-Parkinson-White syndrome].
<AbstractText Label="BACKGROUND/AIM" NlmCategory="OBJECTIVE">The occurrence of atrial fibrillation (AF) in the presence of an accessory pathway (AP) that conducts rapidly is potentially lethal because the rapid ventricular response may lead to ventricular fibrillation (VF). The aim of the study was to determine long-te...
5,790
National Registry on Cardiac Electrophysiology 2007 and 2008.
Clinical electrophysiology remains one of the most dynamic areas of cardiology, with continuing developments in equipping centers with more modern mapping and navigation systems. This has enabled an increase in the number and variety of interventions, resulting in significant improvements in results of therapeutic abla...
5,791
Drug-induced QT prolongation and sudden death.
Prolongation of the QT interval can predispose to a potentially fatal polymorphic ventricular tachycardia called torsades de pointes (TdP). Although usually self-limited, TdP may degenerate into ventricular fibrillation and cause sudden death. Some medications that cause QT prolongation and possible TdP are commonly us...
5,792
[Analysis of response reports of an in-hospital emergency team : Three years experience at a maximum medical care hospital].
In-hospital emergencies can lead to unexpected admission to the ICU, cardiac arrest or even death. Therefore, hospitals have to implement an adequate in-hospital emergency management. The results of the deployment of the in-hospital emergency team of a hospital providing maximum medical care will be presented.</Abstrac...
5,793
Electroanatomic study of the left atrial insertion of an epicardial accessory pathway integrating the coronary sinus.
Endocardial electro-anatomic reconstruction of the left atrium and activation mapping defined a very large atrial accessory pathway insertion with a previously failed ablation attempt. Radiofrequency application inside the coronary sinus (CS), at a site with a sharp electrogram bridging atrial and ventricular electrogr...
5,794
Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation.
Brugada syndrome is a disease known to cause ventricular fibrillation with a structurally normal heart and is linked to SCN5A gene mutation. However, the mechanism by which ventricular fibrillation develops in cases of Brugada-type electrocardiogram without SCN5A mutation has remained unclear. Recently, oxidative stres...
5,795
Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels.
Heart hypertrophy is a common cardiac complication of sustained arterial hypertension and is accompanied by an increased incidence of supraventricular tachyarrhythmia, such as atrial fibrillation and atrial flutter. Verapamil, a phenyalkylamine, belongs to the group of calcium channel antagonists (class IV antiarrhythm...
5,796
Fever-induced precordial ST-segment elevation in a young man.
Brugada syndrome is a rare condition characterized by ST-segment elevation in the right precordial leads. Fever can induce Brugada-like electrocardiographic (ECG) changes. We reported on a 26-year-old male patient with fever and ST-segment elevation in the right precordial leads. Serial cardiac markers were normal and ...
5,797
[Clinical analysis of precaution against atrial fibrillation following cardiac surgery: landiolol or amiodarone?].
Atrial fibrillation following cardiac surgery remains as a most common complication. Tachycardia with atrial fibrillation just after the operation could lead to cardiac deterioration. Although we have to control tachycardia, we often have great difficulties in managing these arrhythmias. Many reports have showed landio...
5,798
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling.
The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology.</AbstractText>In mice with cardiac overexpression of constitutively active Rac1 (RacET), statin-treated RacET, and ...
5,799
Prevalence and clinical characteristics of nondilated cardiomyopathy and the effect of atrial fibrillation.
The treatment of patients with chronic heart failure and those with asymptomatic left ventricular (LV) dysfunction has focused primarily on patients with LV enlargement and a low ejection fraction (EF). Little attention has been paid to those with a normal chamber size and a low EF. We sought to examine the LV geometry...