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6,300
Pharmacological modifications of the stretch-induced effects on ventricular fibrillation in perfused rabbit hearts.
Stretch induces modifications in myocardial electrical and mechanical activity. Besides the effects of substances that block the stretch-activated channels, other substances could modulate the effects of stretch through different mechanisms that affect Ca(2+) handling by myocytes. Thirty-six Langendorff-perfused rabbit...
6,301
Specificities of atrial electrophysiology: Clues to a better understanding of cardiac function and the mechanisms of arrhythmias.
The electrical properties of the atria and ventricles differ in several aspects reflecting the distinct role of the atria in cardiac physiology. The study of atrial electrophysiology had greatly contributed to the understanding of the mechanisms of atrial fibrillation (AF). Only the atrial L-type calcium current is reg...
6,302
Supraventricular arrhythmia induction by an implantable cardioverter defibrillator in a patient with hypertrophic cardiomyopathy.
A 23-year-old woman with obstructive hypertrophic cardiomyopathy and history of frequent unexplained syncope had undergone implantable cardioverter defibrillator implantation. She had experienced frequent inappropriate shocks since implantation due to T-wave oversensing. After one of the syncopal attacks, she was found...
6,303
Ventricular fibrillation as the presenting manifestation of adrenocortical carcinoma.
We describe a case of a young adult in whom sudden cardiac death due to ventricular fibrillation was the presenting manifestation of an adrenocortical carcinoma. The arrhythmia was precipitated by severe hypokalemia induced by the aldosterone-secreting tumor. Sudden death has not been previously described as a manifest...
6,304
CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation.
We sought to evaluate the relation between atrial fibrillation (AF) and the extent of myocardial scarring together with left ventricular (LV) and atrial parameters assessed by late gadolinium-enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM).</AbstractText>AF i...
6,305
B-type natriuretic peptide is predictive of hospitalization in community-dwelling elderly without heart diseases.
To examine prospectively the relationship between plasma B-type natriuretic peptide (BNP) levels in community-dwelling elderly and their hospitalization.</AbstractText>A total number of 644 subjects aged 65 years or older were recruited from the annual community health examinations. Those with a history of stroke or ne...
6,306
A smart method of intraoperative explantation of an aortic bioprosthesis.
Structural prosthetic valve deterioration and nonstructural dysfunction are two common causes of nonfatal valve events following implantation of a bioprosthetic valve. Using caution and skill, implantation of a bioprosthesis is relatively easy. On the other hand, explantation of a bioprosthesis is a challenging and tim...
6,307
Impact of apex-sparing partial left ventriculectomy on left ventricular geometry, function, and long-term survival of patients with end-stage dilated cardiomyopathy.
Currently, partial left ventriculectomy (PLV) has not been widely accepted as a treatment option for dilated cardiomyopathy (DCM) because its results thus far have been inconsistent. In an animal study, apex-sparing PLV (AS-PLV) was shown to produce greater improvement in left ventricle (LV) function than conventional ...
6,308
The spectrum of long-term electrophysiologic abnormalities in patients with univentricular hearts.
Patients with univentricular hearts experience a wide range of electrophysiolgic abnormalities which tend to develop years after cardiovascular surgical interventions. Intra-atrial reentrant tachycardia (atrial flutter) in the Fontan population is the most common arrhythmia and, as such, has the largest body of literat...
6,309
[The influence of radiofrequency (RF) ablation of the atrioventricular junction in atrial fibrillation on left ventricular systolic function, exercise tolerance and quality of life].
In patients with drug refractory atrial fibrillation radiofrequency (RF), ablation of the atrioventricular (AV) junction and pacemaker implantation is an alternative procedure. The aim of this study was to assess the left ventricular systolic function, exercise tolerance and quality of life (QOL) in patients who underw...
6,310
Emergency Medical System response to out-of-hospital cardiac arrest in Milan, Italy.
The objective of this study was to investigate how rapidly the Emergency Medical System provides life support to patients suffering out-of-hospital cardiac arrest in Milan, Italy. The study population included 1426 consecutive participants with out-of-hospital cardiac arrest between January 2007 and October 2008. The m...
6,311
Pulse variations of a conducted energy weapon (similar to the TASER X26 device): effects on muscle contraction and threshold for ventricular fibrillation*.
Conducted energy weapons (such as the Advanced TASER X26 model produced by TASER International), incapacitate individuals by causing muscle contractions. To provide information relevant to development of future potential devices, a "Modifiable Electronic Stimulator" was used to evaluate the effects of changing various ...
6,312
Surface vs. aortic flush cooling during cardiac arrest in pigs.
To investigate the feasibility and efficacy of earlier induction of hypothermia already during the 'no-flow' period of cardiac arrest with non-invasive surface cooling or invasive aortic flush cooling.</AbstractText>This was a prospective randomized experimental study that included 14 pigs, Large White breed (30-38 kg)...
6,313
Prevention of sudden cardiac death: return to sport considerations in athletes with identified cardiovascular abnormalities.
Sudden cardiac death in the athlete is uncommon but extremely visible. In athletes under age 30, genetic heart disease, including hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and ion channel disorders account for the majority of the deaths. Commotio cordis, involving blunt trauma to the...
6,314
Incidence and aetiology of sudden cardiac death in young athletes: an international perspective.
The incidence of sudden cardiac death (SCD) among young athletes is estimated to be 1-3 per 100,000 person years, and may be underestimated. The risk of SCD in athletes is higher than in non-athletes because of several factors associated with sports activity that increase the risk in people with an underlying cardiovas...
6,315
Right ventricular apical lead position is associated with prolonged signal-averaged P-wave duration.
The study aimed to determine if right ventricular apical pacing is associated with adverse change in atrial substrate compared with right ventricular septal pacing.</AbstractText>Patients with septal leads and dual-chamber devices with more than 3 months of follow-up and 70% or higher cumulative percentage of ventricul...
6,316
ECG-voltage in alcoholics and non-alcoholics with acute alcohol intoxication.
Alcohol intoxication is probably the most common intoxication worldwide, and may be lethal. The exact mechanism by which ethanol intoxication contributes to death is unknown, although ventricular tachyarrhythmias degenerating into fibrillation is a possible cause. Alcoholics have increased risk of sudden death and, pos...
6,317
Hypothermia after cardiac arrest.
Mild therapeutic hypothermia (32 degrees C-34 degrees C) is the only therapy that improved neurological outcome after cardiac arrest in a randomized, controlled trial. Induced hypothermia after successful resuscitation leads to one additional patient with intact neurological outcome for every 6 patients treated. It pro...
6,318
A rare connection: fasciculoventricular pathway in PRKAG2 disease.
Mutations in the PRKAG2 gene that regulates the gamma 2 subunit of the AMP-dependent protein kinase A have been associated with the development of AV accessory pathways, cardiac hypertrophy, and conduction system abnormalities. The accessory pathways described in PRKAG2 disease have mostly been AV bypass tracts, as mut...
6,319
The effect of the preshock pause on coronary perfusion pressure decay and rescue shock outcome in porcine ventricular fibrillation.
We sought to determine the effect of the preshock pause (PSP) on coronary perfusion pressure (CPP) decay and subsequent rescue shock (RS) outcome in porcine ventricular fibrillation (VF).</AbstractText>Retrospective analysis of digitally recorded CPP tracings was performed. Ventricular fibrillation was electrically ind...
6,320
Impact of the 2005 American Heart Association cardiopulmonary resuscitation and emergency cardiovascular care guidelines on out-of-hospital cardiac arrest survival.
To describe changes in out-of-hospital cardiac arrest (OOHCA) survival before and after the release of the 2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC).</AbstractText>Data were extracted from an OOHCA registry for 1,681 adult cases of c...
6,321
[Optimized CRT programming: relevance and practical application].
Cardiac resynchronization therapy (CRT) can result in significant clinical improvement in patients with congestive heart failure. Non-response to CRT might be attributable to suboptimal programming. Follow-up has to ensure effective left ventricular (LV) stimulation at rest and also sufficient exercise-dependent atrial...
6,322
Myotonic dystrophy as a potential killer.
A 19-year-old man suffered a cardiac arrest during a promenade with his friends. Cardiac resuscitation was started immediately. Anamnesis uncovered that the father as well as a cousin of the patient suffered from myotonic dystrophy (MD). Follow-up ECG monitoring showed intercurrent III degree AV-block as well as severa...
6,323
Effects of intravenous nifekalant as a lifesaving drug for severe ventricular tachyarrhythmias complicating acute coronary syndrome.
Intravenous amiodarone (AMD) has been used for the treatment of ventricular tachycardia/fibrillation (VT/VF) in emergency care medicine. However, AMD acts slowly and is occasionally accompanied by hypotension and bradycardia. The antiarrhythmic effect of intravenous nifekalant (NIF) was assessed in patients with VT/VF ...
6,324
Current status of implantable cardioverter-defibrillator therapy in heart failure.
Sudden cardiac arrest is one of the leading causes of death in patients with heart failure (HF). The implantable cardioverter-defibrillator (ICD) is the only evidence-based treatment strategy for patients who have survived a life-threatening ventricular arrhythmic event. Randomized clinical trials have shown that speci...
6,325
[Ambulatory electrocardiographic recording (Holter) at the moment of a sudden death event].
Arrhythmic sudden cardiac death due to electrical causes is an important clinical and public health problem, which is not yet solved. Ventricular fibrillation is the first cause of the event. It does not adjust to a single model, being a family with diverse electrocardiographic patterns that reveal different disorganiz...
6,326
Subarachnoid Hemorrhage Associated with Ventricular Fibrillation and Out-of-Hospital Cardiac Arrest.
Aneurysmal subarachonoid hemorrhage (SAH) is a common cause of out-of-hospital cardiac arrest (OHCA). Even after successful resuscitation, most of these SAH patients suffer brain death or enter a vegetative state. To our knowledge, survival without neurological damage from SAH following OHCA is quite a rare event. We t...
6,327
Brugada syndrome case: difficult differentiation between a concealed form and tricyclic antidepressant-induced Brugada sign.
We describe a case of Brugada syndrome, in which recurrent syncope with convulsive seizures was induced after antidepressant treatment. The patient had been treated with five kinds of psychotropic drugs. The twelve-lead ECG after the syncope exhibited an RSR'-pattern in the precordial leads, however, a coved type ST-se...
6,328
The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models.
This study was designed to evaluate the effects of pilocarpine and explore the underlying ionic mechanism, using both aconitine-induced rat and ouabain-induced guinea pig arrhythmia models. Confocal microscopy was used to measure intracellular free-calcium concentrations ([Ca(2+)](i)) in isolated myocytes. The current ...
6,329
A comparison of defibrillation efficacy between different impedance compensation techniques in high impedance porcine model.
Impedance compensation methods differ markedly among manufacturers and can play an important role in defibrillation success. In this study we compared the efficacy of two different commercial defibrillators based on defibrillation success in a high impedance porcine model of cardiac arrest. The first defibrillator (A) ...
6,330
Modern pacemakers: hope or hype?
In recent years, the role of implantable pacing devices has expanded beyond the arrhythmia horizon and contemporary pacemakers' attempt to meet the physiological needs of patients. Modern pacemakers' functions include various modes of dual-chamber pacing, rate-response algorithms with dual sensors for optimum physiolog...
6,331
The association between T-wave morphology and life-threatening ventricular tachyarrhythmias in patients with congestive heart failure.
Whether T-wave morphology descriptors on the 12-lead electrocardiogram (ECG) can predict the occurrence of life-threatening ventricular arrhythmia in patients with advanced congestive heart failure is unclear.</AbstractText>Standard 12-lead ECGs were photoscanned and digitized for analysis in 27 heart failure patients ...
6,332
Outpatient electrical cardioversion of atrial fibrillation: 8 years' experience. Analysis of shock-related arrhythmias.
Outpatient electrical cardioversion (EC) of atrial fibrillation is currently the standard of care. Shock-related arrhythmias may be particularly deleterious in this setting. Preoperative identification of high-risk patients may be very useful.</AbstractText>A retrospective analysis was made of 543 consecutive elective ...
6,333
Persistent atrial standstill and idioventricular rhythm in a patient with thalassemia intermedia.
We present a 57-year old male patient with thalassemia intermedia and right heart failure. He had a 30-year history of anemia and short-term iron therapy without blood transfusion. Hemoglobin level was 7.1 g/dl and hematocrit was 22.7%. White blood-cell and platelet counts, and serum ferritin level were normal. Electro...
6,334
Impact of type of atrial fibrillation and repeat catheter ablation on long-term freedom from atrial fibrillation: results from a multicenter study.
<AbstractText Label="BACKGROUND/OBJECTIVE" NlmCategory="OBJECTIVE">The purpose of this prospective multicenter study was to compare results of catheter ablation in patients with paroxysmal atrial fibrillation (PAF) and those with nonparoxysmal atrial fibrillation (NPAF). The impact and the role of repeat catheter ablat...
6,335
Ventricular fibrillation in Rochester, Minnesota: experience over 18 years.
Survival following out-of-hospital cardiac arrest (OHCA) continues to be disappointingly low world-wide, despite advances in technology and international guidelines for resuscitation. Few cities or emergency medical service (EMS) agencies report patient outcomes after OHCA. Among those who do, survival from witnessed V...
6,336
Atrioventricular (AV) node vagal stimulation by transvenous permanent lead implantation to modulate AV node function: safety and feasibility in humans.
Atrioventricular (AV) node vagal stimulation (AVNVS) has recently emerged as a novel approach to controlling AV dromotropic function. Animal studies have demonstrated that selective epicardial AVNVS is effective in controlling ventricular rate (VR) acutely and in the long term. Endocardial AVNVS has been shown to signi...
6,337
d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing.
This study evaluated antiarrhythmic effects of d,l-sotalol in a canine atrial fibrillation (AF) model with left ventricular dysfunction.</AbstractText>Thirteen beagles (Sotalol group n=7 and Control group n=6) were subjected to atrial tachypacing (ATP) (400 beats/min) with intact atrioventricular conduction for 4 weeks...
6,338
Elevated cardiac troponin I and relationship to persistence of electrocardiographic and echocardiographic abnormalities after aneurysmal subarachnoid hemorrhage.
Cardiac injury persistence after aneurysmal subarachnoid hemorrhage (aSAH) is not well described. We hypothesized that post-aSAH cardiac injury, detected by elevated cardiac troponin I (cTnI), is related to aSAH severity and associated with electrocardiographic and structural echocardiographic abnormalities that are pe...
6,339
A case with catecholaminergic polymorphic ventricular tachycardia unmasked after successful ablation of atrial tachycardias from pulmonary veins.
Catecholaminergic polymorphic ventricular tachycardia (VT) is characterized by polymorphic VT during exercise, and the association of atrial fibrillation (AF) has been reported. However, the mechanism of AF in this disease and the relationship between VT and AF has been obscured. We described a 13-year-old girl who ref...
6,340
Improved prognosis after using mild hypothermia to treat cardiorespiratory arrest due to a cardiac cause: comparison with a control group.
Patients who survive a cardiac arrest have a poor short-term prognosis in terms of mortality and neurological function. The use of mild hypothermia has been investigated in only a few randomized studies, but appears to be effective for treating these patients. The aim of this study was to investigate the effect of this...
6,341
Risk of arrhythmias in myotonic dystrophy: trial design of the RAMYD study.
Myotonic dystrophy type 1 (DM1) is the most frequent muscular dystrophy in adults. DM1 is a multisystem disorder also affecting the heart with an increased incidence of sudden death, which has been explained with the common impairment of the conduction system often requiring pacemaker implantation; however, the occurre...
6,342
Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome.
Brugada syndrome is a life-threatening, inherited arrhythmia disorder associated with autosomal dominant mutations in SCN5A, the gene encoding the human cardiac Na+ channel alpha subunit (Nav1.5). Here, we characterized the biophysical properties of a novel Brugada syndrome-associated Nav1.5 mutation, A551T, identified...
6,343
[Rhythm and conductivity disorders in patients at the initial stages of metabolic syndrome].
The aim of the work was to evaluate the prevalence of cardiac rhythm and conductance disturbances in patients with early manifestations of metabolic syndrome (MS). 24-hour ECG monitoring was undertaken in 105 patients meeting AHA/NHLBI (2005) MS criteria and in 79 healthy subjects. Exclusion criteria were the presence ...
6,344
Intrapericardial delivery of amiodarone and sotalol: atrial transmural drug distribution and electrophysiological effects.
Amiodarone and sotalol are frequently used in the treatment of atrial fibrillation. However, oral and intravenous (IV) therapy with these drugs has suboptimal efficacy and is associated with serious extracardiac side effects. We hypothesized that intrapericardial (IPC) delivery produces antiarrhythmic effects at lower ...
6,345
Idiopathic ventricular arrhythmia in a young man: a case report.
Ventricular ectopics can potentially lead to ventricular fibrillation (VF). A case of idiopathic VF that began as ventricular bigeminy is presented. A 30-year-old man lost consciousness transiently while driving but made a complete recovery soon after. He was pale and sweaty at the onset of the event. There was neither...
6,346
Coronary vasospasm triggered ventricular fibrillation delayed after radiofrequency ablation of the right accessory pathway.
Ventricular fibrillation associated with coronary vasospasm developed 8 h after successful radiofrequency (RF) ablation of the right accessory pathway in an 81-year-old male. A segment of the coronary vasospasm was located close to the accessory pathway, where seven RF ablations had been applied. Although rare, physici...
6,347
Intracardiac QT variability in patients with structural heart disease on class III antiarrhythmic drugs.
We previously showed that increased intracardiac repolarization lability predicts life-threatening ventricular arrhythmias in patients with structural heart disease. Patients with structural heart disease frequently take antiarrhythmic drugs (AADs), which directly affect repolarization. The effect of AADs on the predic...
6,348
Use of ECMO to temporize circulatory instability during severe Brugada electrical storm.
We describe the use of extracorporeal membrane oxygenation to temporize circulatory instability during almost incessant ventricular fibrillation in a patient with Brugada syndrome who had electively discontinued chronic amiodarone therapy. The extracorporeal membrane oxygenation was continued for 3 days after emergent ...
6,349
Long-term outcome of mitral valve repair for infective endocarditis.
In patients with mitral endocarditis, reconstruction of the damaged mitral valve (MV) is still challenging, and its durability remains unknown. We evaluated the long-term outcomes of MV repair for mitral regurgitation (MR) in patients with infective endocarditis.</AbstractText>From 1991 to 2006, 633 patients had MV rep...
6,350
Prognosis among survivors of primary ventricular fibrillation in the percutaneous coronary intervention era.
Sudden cardiac death (SCD) constitutes one of the most prevalent modes of death and is mainly caused by primary ventricular fibrillation (VF), that is, VF in the acute setting of a first acute myocardial infarction (MI). Current guidelines for secondary prevention of SCD are based on data from the thrombolysis era. We ...
6,351
Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: a 12-month follow-up study.
Although left ventricular (LV) and left atrial (LA) echo indices may reliably reflect loading conditions in patients with hypertrophic cardiomyopathy (HCM), little is known about 2-dimensional strain imaging. We evaluated LV and LA 2-dimensional strain imaging in relation to long-term outcome in patients with HCM.</Abs...
6,352
Local conduction block of the atria by premature stimulus in a patient with Brugada syndrome.
A 46-year-old man with type II Brugada electrocardiogram pattern changed to a type I Brugada type electrocardiogram pattern by class I antiarrhythmic drug (pilsicainide) underwent electrophysiologic study. Ventricular fibrillation was induced by double extrastimuli from the right ventricular (RV) apex. Monophasic actio...
6,353
Development of a toolbox for electrocardiogram-based interpretation of atrial fibrillation.
Atrial fibrillation (AF) develops as a consequence of an underlying heart disease such as fibrosis, inflammation, hyperthyroidism, elevated intra-atrial pressures, and/or atrial dilatation. The arrhythmia is initiated by, or depends on, ectopic focal activity. Autonomic dysfunction may also play a role. However, in mos...
6,354
New-onset atrial fibrillation as first clinical manifestation of latent Brugada syndrome: prevalence and clinical significance.
To evaluate the prevalence, clinical significance, and prognosis of latent Brugada syndrome (BrS) in patients with new-onset atrial fibrillation (AF) unmasked by class 1C antiarrhythmic drugs.</AbstractText>Between January 2000 and June 2008, all consecutive patients with new-onset AF, who after flecainide exhibited ty...
6,355
Arrhythmias originating from the right ventricular outflow tract: how to distinguish "malignant" from "benign"?
Idiopathic ventricular tachycardia (VT) originating from the right ventricular outflow tract (RVOT) in patients without structural heart diseases is generally considered as a benign ventricular arrhythmia (VA). However, "malignant" VA, ventricular fibrillation (VF), and/or polymorphic VT are occasionally initiated by V...
6,356
Transient local injury current in right ventricular electrogram after implantable cardioverter-defibrillator shock predicts heart failure progression.
This study aimed to identify an early marker of functional impairment after an implantable cardioverter-defibrillator (ICD) shock as a predictor of heart failure progression.</AbstractText>The ICD population has substantial risk of death due to progressive pump failure.</AbstractText>Near-field (NF) bipolar right ventr...
6,357
[Myocardial protection of cold autoblood cardioplegia in infants with congenital heart disease].
To study the effects of cold autoblood cardioplegia on oxygen free radicals in the myocardium in infants who underwent cardiopulmonary bypass and to explore the possible mechanism of myocardial protection of autoblood cardioplegia.</AbstractText>Thirty infants with acyanotic congenital heat disease (CHD) (weight&lt; or...
6,358
[Antiarrhythmic effect of ethyl acetate extract from Chrysanthemum Morifolium Ramat on rats].
To investigate the effect of ethyl acetate extract from Chrysanthemum Morifolium Ramat (CME) on experimental arrhythmia induced by ischemia/reperfusion or aconitine in rats and to explore its underlying mechanisms.</AbstractText>Arrhythmia model in intact rat was induced by aconitine (30 microg/kg body weight, i.v.). I...
6,359
Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity.
To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF).</AbstractText>Ten healthy adult dogs were studied to correlate V(p) with the invasive minimum valu...
6,360
Reconstructing and registering three-dimensional rotational angiogram of left atrium during ablation of atrial fibrillation.
Three-dimensional (3D) image of left atrium (LA) can greatly facilitate ablation of atrial fibrillation (AF). Reconstructing method using computed tomography (CT) has certain limitations. The 3D image of LA can be intraprocedurally reconstructed by a rotational angiography technique.</AbstractText>Forty-six patients un...
6,361
Duality of conduction in an atriofascicular pathway during antidromic tachycardia.
Cycle length alternation in atrioventricular reentrant tachycardia due to alternating conduction time over the dual atrioventricular (AV) nodal pathways has been well described. Atriofascicular pathways with decremental conduction characteristics (Mahaim fibers) are known to contain accessory AV nodal tissue. We descri...
6,362
The use of vasopressin for treating vasodilatory shock and cardiopulmonary arrest.
To discuss 3 potential mechanisms for loss of peripheral vasomotor tone during vasodilatory shock; review vasopressin physiology; review the available animal experimental and human clinical studies of vasopressin in vasodilatory shock and cardiopulmonary arrest; and make recommendations based on review of the data for ...
6,363
Successful biphasic transthoracic defibrillation of a dog with prolonged, refractory ventricular fibrillation.
To describe a case of spontaneous ventricular fibrillation in a dog in which biphasic defibrillation was life saving.</AbstractText>Ventricular fibrillation occurred in a 7-year-old female Australian Heeler during recovery from anesthesia following pacemaker implantation. Resuscitative efforts including immediate deliv...
6,364
Dronedarone: a new antiarrhythmic agent for the treatment of atrial fibrillation.
In the armamentarium for rhythm control, amiodarone has been a mainstay of therapy for the management of atrial fibrillation (AF). Although amiodarone has shown to be effective in maintaining sinus rhythm, it has many extracardiac adverse effects. Dronedarone, a benzofuran amiodarone derivative, is structurally modifie...
6,365
Survival analysis in patients with preserved left ventricular function and standard indications for permanent cardiac pacing randomized to right ventricular apical or septal outflow tract pacing.
Optimal right ventricular (RV) pacing site in patients referred for permanent cardiac pacing remains controversial. A prospective randomized trial was done to compare long-term effect of permanent RV apex (RVA) vs RV outflow tract (RVOT) pacing on the all-cause and cardiovascular mortality.</AbstractText>A total of 122...
6,366
Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.
Non-sustained ventricular tachycardia (NSVT) during ambulatory electrocardiographic monitoring (typically occurring at rest or during sleep) is associated with an increased risk of sudden cardiac death in patients with hypertrophic cardiomyopathy. The prevalence and prognostic significance of ventricular arrhythmias du...
6,367
Anticoagulation in patients with heart failure.
The decision to anti-coagulate patients with heart failure (HF) is a difficult one, with limited data available to support clinical judgment. Thromboembolic complications, both arterial (stroke) and venous (deep vein thrombosis and pulmonary embolism), remain a significant cause of mortality and morbidity in this popul...
6,368
Dronedarone.
Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been dev...
6,369
Anesthetic management of apicoaortic bypass in patients with severe aortic stenosis.
Apicoaortic bypass (AAB), or apicoaortic conduit insertion, is a conventional surgical method that has been regaining attention due to the aging population and the increasing number of repeat surgeries. The indication for the procedure has been extended as an alternative for aortic stenosis when the usual sternotomy or...
6,370
Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training.
Sudden cardiac death resulting from ventricular tachyarrhythmias remains the leading cause of death in industrially developed countries, accounting for between 300,000 and 500,000 deaths each year in the United States. Yet, despite the enormity of this problem, both the identification of factors contributing to ventric...
6,371
T-wave inversion: cardiac memory or myocardial ischemia?
This article presents a case report of a 74-year-old man with T-wave inversion (TwI) in atrial fibrillation noted during routine pacemaker interrogation. The patient was seen for routine pacemaker interrogation, at which time he was noted to have underlying atrial fibrillation. A12-lead electrocardiogram of the atrial ...
6,372
A comparison of 2 types of chest compressions in a porcine model of cardiac arrest.
Chest compressions performed by some medical workers are of poor quality, which are too few and shallow with incomplete release. This study was designed to compare the effects of these clinical quality chest compressions with standard manual chest compressions in a porcine model of cardiac arrest.</AbstractText>Ventric...
6,373
Persistent ventricular fibrillation during therapeutic hypothermia and prolonged high-dose vasopressor therapy: case report.
Recent emphasis on high quality prehospital cardiopulmonary resuscitation has resulted in more out-of-hospital cardiac arrest victims surviving to the emergency department. As such, standardized in-hospital post-cardiac arrest care is necessary to assure optimal neurological recovery. Although therapeutic hypothermia h...
6,374
Potential danger of ocular compression in paroxysmal supraventricular tachycardia in patients with latent preexcitation.
The vagal maneuver is the first line of therapeutic available for patients with paroxysmal supraventricular tachycardia. It increases vagal tone and includes the traditional ocular compression, carotid sinus massage, and Valsalva maneuver. A 40-year-old man was admitted because of 180 beats/min regular narrow QRS-compl...
6,375
Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome.
Enhanced dispersion of repolarization has been proposed as an important mechanism in long QT related arrhythmias. Dispersion can be dynamic and can be augmented with the occurrence of spatially out-of-phase action potential duration (APD) alternans (discordant alternans; DA). We investigated the role of tissue heteroge...
6,376
Modification of cardiovascular ion channels by gene therapy.
Delivery of genes to the heart and vasculature for therapeutic purposes is an exciting strategy that is approaching clinical reality. Abnormalities of expression or function of ion channels is central to many cardiovascular diseases and gene delivery to modify ion channels is an appealing alternative to traditional the...
6,377
[Differences between hospitals in prognosis after resuscitated out-of-hospital cardiac arrest patients].
There are substantial differences in long-term survival of patients resuscitated from out-of-hospital cardiac arrest, and the level of care during hospitalization may be a contributing factor. The purpose of this study was to determine if a difference in long-term prognosis between hospitals could be detected in patien...
6,378
[Hypertension and the heart].
Within the latest ten years research in left ventricular hypertrophy as cardiac target organ damage has uncovered its prognostic importance, and studies indicate that treatment with angiotensin II receptor blockade is most effective in reducing left ventricular hypertrophy. In addition, reduction of left ventricular ma...
6,379
[Aortic valve replacement through right thoracotomy; report of a case].
A 78-year-old female was admitted to our hospital with a diagnosis of severe aortic valve regurgitation. She had had dyspnea on effort and syncope twice in 5 months. She had also suffered from right pneumonia 8 years before, and her respiratory function was severely constrictive. Chest X-ray showed her mediastinum sign...
6,380
Dronedarone: a promising alternative for the management of atrial fibrillation.
Atrial fibrillation (AF) is the most frequently encountered chronic arrhythmia associated with significant morbidity. It is generally encountered in the elderly, and will presumably become more prevalent in the future due to the increasing proportion of the elderly in the population. Major studies on AF have demonstrat...
6,381
Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart.
Gelsolin (gsn) is involved in the reorganization of the cytoskeleton, thereby modulating cardiomyocytal L-type Ca(2+) channels. We investigated global cardiac electrophysiological characteristics in a gsn-deficient (gsn(-/-)) mouse strain.</AbstractText>Using transvenous catheterization, atrial and ventricular stimulat...
6,382
Current concepts and management strategies in atrial flutter.
After atrial fibrillation, atrial flutter (AFL) is the most important and most common atrial tachyarrhythmia. Atrial flutter describes an electrocardiographic model of atrial tachycardia &gt;or=240/min, with a uniform and regular continuous wave-form. There is classically a 2:1 conduction across the atrioventricular (A...
6,383
Bayesian classification of clinical practice guidelines.
Clinical practice guidelines are generally constructed from an admixture of expert consensus opinion, case-control studies, and randomized controlled trials (RCTs) and are categorized according to the methodological quality of the underlying data (level of evidence) and the trade-off between the benefits and risks of t...
6,384
The relationship between high-frequency right ventricular pacing and paroxysmal atrial fibrillation burden.
Right ventricular pacing increases the risk of persistent atrial fibrillation (AF) in the long term. The effects of right ventricular pacing on paroxysmal AF (PAF) are unknown. The aim was to examine the effect of right ventricular pacing on AF burden (AFB) in patients with symptomatic drug-resistant PAF. Pooled analys...
6,385
Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients.
MMP-9 plays an important role in the pathogenesis of arrhythmogenic atrial remodeling, and may contribute to the development and persistence of atrial fibrillation (AF). Functional polymorphisms in the MMP-9 gene which lead to altered MMP-9 production and/or activity may modulate an individual's susceptibility to AF.</...
6,386
Incidence of atrial fibrillation during very long-term follow-up after radiofrequency ablation of typical atrial flutter.
Radiofrequency ablation is an effective treatment for typical atrial flutter (AFL) but long-term results may be hampered by atrial fibrillation (AF).</AbstractText>To determine the incidence and predictors of AF during very long-term follow-up after radiofrequency ablation of typical AFL.</AbstractText>From November 19...
6,387
Who survives cardiac arrest in the intensive care units?
The aim of this study was to evaluate the factors related to outcome regarding in-intensive care unit (ICU) cardiac arrest (IICA) in a university hospital.</AbstractText>Adult nontraumatic ICU patients who sustained IICA were prospectively enrolled. Several patient and event-related variables, as well as outcomes, were...
6,388
[Treatment of atrial fibrillation in heart failure].
Treatment of patients with both atrial fibrillation and heart failure remains uneasy. In theory maintenance of sinus rhythm is desirable but the only pharmacological intervention able to do it safely is amiodarone. A trial of strategy randomisation, restoration of sinus rhythm or slowing of atrial fibrillation, has bee...
6,389
Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging.
It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction.</AbstractText>Forty two patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic resonanc...
6,390
Methods for calculating coronary perfusion pressure during CPR.
Coronary perfusion pressure (CPP) is a major indicator of the effectiveness of cardiopulmonary resuscitation in human and animal research studies, however, methods for calculating CPP differ among research groups. Here we compare the 6 published methods for calculating CPP using the same data set of aortic (Ao) and rig...
6,391
Predictive value of cardiac autonomic indexes and MIBG washout in ICD recipients with mild to moderate heart failure.
We aimed at evaluating the combined use of heart rate variability (HRV), baroreflex sensitivity (BRS), and MIBG imaging in the risk stratification for sudden cardiac death (SCD) of patients with mild to moderate heart failure.</AbstractText>Twenty-five patients (17 male and 8 female, mean age 63 +/- 5 years, mean LVEF ...
6,392
Effect of hypothermia therapy after outpatient cardiac arrest due to ventricular fibrillation.
Several investigators have emphasized the positive effect of hypothermia therapy on patients who have suffered from cardiac arrest. Salvaging patients from circulatory collapse is a pivotal task, but it is unclear whether additional hypothermia can practically contribute to an improvement in the neurological outcome.</...
6,393
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
In the late 1980's reports linking the non-sedating antihistamines terfenadine and astemizole with torsades de pointes, a form of ventricular tachyarrhythmia that can degenerate into ventricular fibrillation and sudden death, appeared in the clinical literature. A substantial body of evidence demonstrates that the arrh...
6,394
Passive oxygen insufflation is superior to bag-valve-mask ventilation for witnessed ventricular fibrillation out-of-hospital cardiac arrest.
Assisted ventilation may adversely affect out-of-hospital cardiac arrest outcomes. Passive ventilation offers an alternate method of oxygen delivery for these patients. We compare the adjusted neurologically intact survival of out-of-hospital cardiac arrest patients receiving initial passive ventilation with those rece...
6,395
Efficacy of antiarrhythmic drugs in arrhythmogenic right ventricular cardiomyopathy: a report from the North American ARVC Registry.
This study sought to examine the efficacy of empiric antiarrhythmic drugs in a rigorously characterized cohort of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients.</AbstractText>Antiarrhythmic drugs are important in protecting against ventricular arrhythmias in ARVC, but no studies have provided data in ...
6,396
Relation of N-terminal pro-B-type natriuretic peptide to symptoms, severity, and left ventricular remodeling in patients with organic mitral regurgitation.
Natriuretic peptides reflect cardiac stress and may therefore be useful in the management of patients with valvular heart disease. Data regarding these biomarkers in organic mitral regurgitation (MR) are sparse. In this study, 144 patients with moderate or severe organic MR were prospectively enrolled in an observation...
6,397
Relation between myocardial infarct size and ventricular tachyarrhythmia among patients with preserved left ventricular ejection fraction following fibrinolytic therapy for ST-segment elevation myocardial infarction.
In the era of early reperfusion therapy for ST-segment elevation myocardial infarction, preserved left ventricular (LV) function is common. Despite preservation of LV ejection fraction (LVEF), there remains a spectrum of risk for adverse cardiovascular events, including ventricular tachycardia (VT) and ventricular fibr...
6,398
Direct His bundle pacing post AVN ablation.
Atrioventricular nodal (AVN) ablation with concomitant pacemaker implantation is one of the strategies that reduce symptoms in patients with atrial fibrillation (AF). However, the long-term adverse effects of right ventricular (RV) apical pacing have led to the search for alternating sites of pacing. Biventricular paci...
6,399
Cardioversion for atrial fibrillation: treatment options and advances.
Atrial fibrillation (AF) is associated with significant morbidity and mortality. There are two basic approaches to managing AF: slowing the ventricular rate, while allowing the arrhythmia to continue (the rate-control approach), and restoring and maintaining sinus rhythm (the rhythm-control approach) with antiarrhythmi...