Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
6,100 | Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans. | Beat-to-beat alternans of cellular repolarization is closely linked to ventricular arrhythmias in humans. We hypothesized that sarcoplasmic reticulum calcium reuptake by SERCA2a plays a central role in the mechanism of cellular alternans and that increasing SERCA2a gene expression will retard the development of cellula... |
6,101 | Coronary perfusion pressure and return of spontaneous circulation after prolonged cardiac arrest. | The amount of myocardial perfusion required for successful defibrillation after prolonged cardiac arrest is not known. Coronary perfusion pressure (CPP) is a surrogate for myocardial perfusion. One limited clinical study reported that a threshold of 15 mmHg was necessary for return of spontaneous circulation (ROSC), an... |
6,102 | Comparison of low-energy versus high-energy biphasic defibrillation shocks following prolonged ventricular fibrillation. | Since the initial development of the defibrillator, there has been concern that, while delivery of a large electric shock would stop fibrillation, it would also cause damage to the heart. This concern has been raised again with the development of the biphasic defibrillator.</AbstractText>To compare defibrillation effic... |
6,103 | Public Access Defibrillation. | In the United States, 250,000 people die from a cardiac arrest every year. Despite a well established emergency medical response system, survival from out-of-hospital cardiac arrest remains poor in United States cities. Paramount to achieving successful resuscitation of a cardiac arrest victim is provision of early def... |
6,104 | Study of resuscitated in- and out-hospital cardiorespiratory arrest patients undergoing therapeutic hypothermia. | To determine the characteristics of patients undergoing standard institutional protocol for management of resuscitated patients after a cardiac arrest episode, including therapeutic hypothermia.</AbstractText>This was a retrospective analysis of 26 consecutive patients admitted following cardiac arrest, between January... |
6,105 | A Case of Amiodarone-Induced Thyrotoxicosis: A diagnostic and therapeutic dilemma. | Amiodarone is an iodine rich agent widely used for the treatment of ventricular arrhythmias, paroxysmal supraventricular tachycardia, atrial fibrillation and flutter. However 14-18% of patients treated with amiodarone develop overt thyroid dysfunction in the form of either amiodarone-induced thyrotoxicosis (AIT) or ami... |
6,106 | History of surgery for atrial fibrillation. | There is a rich history of surgery for atrial fibrillation. Initial procedures were aimed at controlling the ventricular response rate. Later procedures were directed at converting atrial fibrillation to normal sinus rhythm. These culminated in the Cox Maze III procedure. While highly effective, the complexity and morb... |
6,107 | The effects of phase duration on defibrillation success of dual time constant biphasic waveforms. | The effects of first and second phase duration of biphasic waveforms on defibrillation success were evaluated in a guinea pig model of ventricular fibrillation (VF). We hypothesized that waveform duration, and especially the first phase duration, played a main role on defibrillation efficacy in comparison to energy, cu... |
6,108 | Predicting survival after out-of-hospital cardiac arrest: role of the Utstein data elements. | Survival after out-of-hospital cardiac arrest depends on the links in the chain of survival. The Utstein elements are designed to assess these links and provide the basis for comparing outcomes within and across communities. We assess whether these measures sufficiently predict survival and explain outcome differences.... |
6,109 | Vasospastic heart failure: multiple spasm may cause transient heart failure? | There have been no reports concerning the correlation between heart failure and coronary artery spasm.</AbstractText>From January 2000 to December 2007, 201 patients with heart failure were hospitalized at our institution. We could perform coronary arteriography and spasm provocation tests in 37 (22 men, 67±11 yea... |
6,110 | Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function. | Plasma B-type natriuretic peptide (BNP) levels are determined by several factors. The presence of atrial fibrillation (AF) is one of these factors. Meanwhile, plasma BNP levels are well correlated with left ventricular (LV) filling pressure in patients with sinus rhythm. Furthermore, LV filling pressure can be estimate... |
6,111 | Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides. | Co-ordinated electrical activation of the heart is maintained by intercellular coupling of cardiomyocytes via gap junctional channels located in the intercalated disks. These channels consist of two hexameric hemichannels, docked to each other, provided by either of the adjacent cells. Thus, a complete gap junction cha... |
6,112 | Relationships of CRP and P wave dispersion with atrial fibrillation in hypertensive subjects. | Although inflammation has been shown to be implicated in the pathophysiology of atrial fibrillation (AF), little is known about its involvement in the accompanying atrial electrical remodeling expressed by P wave dispersion (P(disp)).</AbstractText>Fifty hypertensive subjects with documented paroxysmal AF (AF group) an... |
6,113 | The effect of open-chest cardiac resuscitation on mitral regurgitant flow: an on-line transesophageal echocardiographic study in dogs. | We sought to determine the effect of cardiac massage on a pre-existing regurgitant mitral valve during open-chest cardiopulmonary resuscitation (OCCPR) in an animal experiment.</AbstractText>Our study included 29 dogs that were used as experimental models. We anesthetized them and inserted a transesophageal echocardiog... |
6,114 | Incidence and predictors of silent embolic cerebral infarction following diagnostic coronary angiography. | Coronary angiography (CAG) is an invasive diagnostic procedure, which could lead to procedure related complications. One of the well known post-procedural complications is cerebral embolic infarction with or without symptoms. Silent embolic cerebral infarction (SECI) has clinical significance because it can progress to... |
6,115 | Prevalence of inappropriate use of digoxin in 136 patients on digoxin and prevalence of use of warfarin or aspirin in 89 patients with persistent or paroxysmal atrial fibrillation. | Of 136 patients, mean age 72 years, receiving digoxin in the hospital or in the medical clinic, 47 (35%) had heart failure with reduced left ventricular ejection fraction and symptoms despite optimal medical therapy, 82 (60%) had persistent atrial fibrillation (AF), and 7 (5%) had paroxysmal AF. The prevalence of inapp... |
6,116 | Left atrial pressure reduction for mitral stenosis reverses left atrial direction-dependent conduction abnormalities. | Left atrial (LA) stretch-associated electrophysiological changes in patients with mitral stenosis (MS) predispose to atrial fibrillation. We hypothesized that the normalization of the pressure gradient by percutaneous transvenous mitral balloon valvotomy (PTMV) affects LA but not right atrial (RA) conduction, depending... |
6,117 | RR-interval irregularity precedes ventricular fibrillation in ST elevation acute myocardial infarction. | Sudden cardiac arrest is a leading cause of death in industrialized countries, and ischemic ventricular fibrillation (VF) is a frequent cause.</AbstractText>The purpose of this study was to determine whether patients with ST elevation myocardial infarction (STEMI) who develop ischemic VF show more overall RR-interval i... |
6,118 | The impact of dopamine on hemodynamics, oxygen metabolism, and cerebral resuscitation after restoration of spontaneous circulation in pigs. | Restoration of spontaneous circulation after cardiopulmonary resuscitation in cardiac arrest patients does not always signal a completely successful outcome. Functional deficiencies of the nervous system are found in many survivors of cardiac arrest.</AbstractText>To study the effects of dopamine-induced elevated blood... |
6,119 | Vernakalant hydrochloride for the treatment of atrial fibrillation. | Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Rhythm control strategy for AF is limited by drug toxicity and side effects, and recent trials have shown that this strategy is not superior to a rate control one. New antiarrhythmic drugs, free of undesired effects, would enhance ... |
6,120 | [Effect of shensongyangxin capsule on myocardial remodeling and ventricular fibrillation threshold value in rat with coronary artery ligation]. | To study the effect of shensongyangxin capsule on myocardial remodeling and ventricular fibrillation characteristics in rat with coronary artery ligation.</AbstractText>Twenty-three male rats were randomly divided into sham-group (n = 5), model group (n = 6), anmiodarone group (n = 6) and shensongyangxin capsule group ... |
6,121 | Cardiac resynchronization therapy is effective even in elderly patients with comorbidities. | The purpose of this study was to compare the effects of cardiac resynchronization therapy (CRT) in elderly patients (> or =65 years) with younger patients and to assess the impact of comorbidities in CRT remodeling response.</AbstractText>This is a prospective study of 87 consecutive patients scheduled for CRT who u... |
6,122 | Catheter ablation of arrhythmic storm triggered by monomorphic ectopic beats in patients with coronary artery disease. | Frequent episodes of polymorphic ventricular tachycardias/ventricular fibrillation (VT/VF) in patients with coronary artery disease can be triggered by monomorphic ventricular premature beats (VPBs) and thus, amenable to catheter ablation. The goal of this study was to review single-center experience in catheter ablati... |
6,123 | Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. | Functional foods and nutraceuticals are becoming popular alternatives to pharmacological treatments by providing health benefits and (or) reducing the risk of chronic diseases. Flaxseed is a rich source of 3 components with demonstrated cardioprotective effects: the omega-3 fatty acid alpha-linolenic acid (ALA), dietar... |
6,124 | PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions. | Long-QT syndrome causes torsade de pointes arrhythmia, ventricular fibrillation, and sudden death. The most commonly inherited form of long-QT syndrome, LQT1, is due to mutations on the potassium channel gene KCNQ1, which forms one of the main repolarizing cardiac K(+) channels, IKs. IKs has been shown to be regulated ... |
6,125 | Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. | Intravenous access and drug administration are included in advanced cardiac life support (ACLS) guidelines despite a lack of evidence for improved outcomes. Epinephrine was an independent predictor of poor outcome in a large epidemiological study, possibly due to toxicity of the drug or cardiopulmonary resuscitation (C... |
6,126 | Atrial tachycardia with 1:1 atrioventricular conduction precipitated by propafenone. | A 58-year-old man presented to the emergency department with sudden onset rapid palpitations and significant presyncope while walking on the flat. The previous day he had undergone DC cardioversion for atrial fibrillation (AF) which had been initially successful. However, 6 h after cardioversion he was aware of intermi... |
6,127 | Incidence and predictors of silent cerebral embolism during pulmonary vein catheter ablation for atrial fibrillation. | Left atrial catheter ablation of the pulmonary veins (PV) has evolved as an important therapeutic option for the treatment of atrial fibrillation (AF). We aimed to investigate the incidence and predictors of silent cerebral embolism associated with PV catheter ablation, detected by diffusion-weighted magnetic resonance... |
6,128 | Should patients with asymptomatic severe mitral regurgitation with good left ventricular function undergo surgical repair? | A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, 'Does severe asymptomatic mitral regurgitation (MR) require surgery or is watch and wait the optimal strategy?'. Over 103 papers were found using the reported search, and 10 represented the best evidence... |
6,129 | Frequency of cardiac death in children with idiopathic dilated cardiomyopathy. | The prognosis in children with idiopathic dilated cardiomyopathy (IDC) is guarded, with the 5-year mortality rate ranging from 14% to 50%, owing to sudden cardiac death (SCD) or pump failure. The risk factors for SCD in adults with IDC include asymptomatic nonsustained ventricular tachycardia and poor left ventricular ... |
6,130 | Lethal arrhythmia and corticosteroid insufficiency. | We describe a case of isolated adrenocorticotropic hormone deficiency that showed ventricular fibrillation associated with QT prolongation. A 72-year-old man was admitted because of consciousness disorder caused by severe hypoglycemia. On the second hospital day, QT intervals were unexpectedly prolonged and ventricular... |
6,131 | Pharmacological modulations of cardiac ultra-rapid and slowly activating delayed rectifier currents: potential antiarrhythmic approaches. | Despite the emerging new insights into our understandings of the cellular mechanisms underlying cardiac arrhythmia, medical therapy for this disease remains unsatisfactory. Atrial fibrillation (AF), the most prevalent arrhythmia, is responsible for significant morbidity and mortality. On the other hand, ventricular fib... |
6,132 | Non-atheroprotective effects of statins: a systematic review. | Since the introduction of HMG-CoA reductase inhibitors (statins) for lowering lipids, a large amount of data has been published demonstrating their potential benefits in conditions as varied as cancer, osteoporosis, and Alzheimer's dementia. We reviewed the published literature on MEDLINE from articles between 1950 and... |
6,133 | Diastolic intracellular calcium-membrane voltage coupling gain and postshock arrhythmias: role of purkinje fibers and triggered activity. | Recurrent ventricular arrhythmias after initial successful defibrillation are associated with poor clinical outcome.</AbstractText>We tested the hypothesis that postshock arrhythmias occur because of spontaneous sarcoplasmic reticulum Ca release, delayed afterdepolarization (DAD), and triggered activity (TA) from tissu... |
6,134 | A comparison of atrial arrhythmias after heart or double-lung transplantation at a single center: insights into the mechanism of post-operative atrial fibrillation. | We compared the incidence of atrial arrhythmias in double-lung transplant patients versus heart transplant patients to gain insight into factors that contribute to post-operative atrial fibrillation (AF).</AbstractText>Atrial fibrillation is a common complication after thoracic surgery. Pulmonary vein isolation is an e... |
6,135 | Role of the CHADS2 score in the evaluation of thromboembolic risk in patients with atrial fibrillation undergoing transesophageal echocardiography before pulmonary vein isolation. | The goals of this study were to determine: 1) if low-risk patients assessed by a CHADS(2) score, a clinical scoring system quantifying a risk of stroke in patients with atrial fibrillation (AF), require a routine screening transesophageal echocardiogram (TEE) before pulmonary vein isolation (PVI); and 2) the relationsh... |
6,136 | Atrial fibrillation at baseline and during follow-up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). | The ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) determined that treatment with amlodipine, lisinopril, or doxazosin was not superior to thiazide-like diuretic (chlorthalidone) in preventing coronary heart disease (CHD) or other cardiovascular events. This subanalysis examines ba... |
6,137 | Appropriate evaluation and treatment of heart failure patients after implantable cardioverter-defibrillator discharge: time to go beyond the initial shock. | Multiple clinical trials support the use of implantable cardioverter-defibrillators (ICDs) for prevention of sudden cardiac death in patients with heart failure (HF). Unfortunately, several complicating issues have arisen from the universal use of ICDs in HF patients. An estimated 20% to 35% of HF patients who receive ... |
6,138 | Spontaneous pericardial hematoma with familial amyloid polyneuropathy. | There are more than a few risks of hemorrhage complication in patients with amyloidosis. Although most cases with amyloidosis exhibit minor bleeding manifestations, they can be occasionally associated with life-threatening problems. To our knowledge, there are only a few cases of spontaneous pericardial hematoma associ... |
6,139 | Prevalence, clinical correlates and treatment of permanent atrial fibrillation among the elderly: insights from the first prospective population-based study in rural Greece. | To investigate the prevalence of permanent atrial fibrillation (AF), its clinical associated conditions and treatment status in the elderly population in rural Greece. 720 people (46.1% males) older than 65 years (mean age: 72.5 +/- 5.7 years) living in four villages in rural Greece were screened with an electrocardiog... |
6,140 | Remote monitoring of cardiovascular implantable electronic devices: prerequisite or luxury? | The number of patients implanted with cardiovascular electronic devices (CIED) like implantable defibrillators (ICD), cardiac resynchronisation (CRT) devices, and pacemakers continues to grow. These devices require regular follow-up interrogation in dedicated device clinics. Contemporary CIED are capable of wireless re... |
6,141 | Implantable cardioverter-defibrillators. | The automatic implantable cardioverter-defibrillator (AICD) is the most effective treatment for patients with life-threatening ventricular tachycardia or ventricular fibrillation. The American College of Cardiology/American Heart Association class I, IIa, and III indications for an AICD are discussed. Patients with AIC... |
6,142 | Long-term outcome associated with early repolarization on electrocardiography. | Early repolarization, which is characterized by an elevation of the QRS-ST junction (J point) in leads other than V(1) through V(3) on 12-lead electrocardiography, has been associated with vulnerability to ventricular fibrillation, but little is known about the prognostic significance of this pattern in the general pop... |
6,143 | High-resolution electrical mapping of depolarization and repolarization alternans in an ischemic dog model. | Cardiac electrical alternans have been associated with spontaneous ventricular arrhythmias during myocardial ischemia. The study aims were to use a new algorithm to measure depolarization and repolarization alternans from epicardial electrograms in an ischemia model and to evaluate which features are predictive of vent... |
6,144 | Avoiding medical error during electrical cardioversion of atrial fibrillation: prevention of unsynchronized shock delivery. | Electrical cardioversion of atrial fibrillation is now commonly performed in veterinary medicine. Successful timing of the delivery of energy is important in order to avoid ventricular fibrillation. This brief communication describes how to ensure that proper energy delivery is performed. |
6,145 | Nifekalant versus lidocaine for in-hospital shock-resistant ventricular fibrillation or tachycardia. | To compare the efficacy and safety of nifekalant, a pure class III anti-arrhythmic drug, and lidocaine in patients with shock-resistant in-hospital ventricular fibrillation (VF) or ventricular tachycardia (VT).</AbstractText>Between August 2005 and March 2008, we conducted a prospective, two-arm, cluster observational ... |
6,146 | The feasibility of inducing mild therapeutic hypothermia after cardiac resuscitation using iced saline infusion via an intraosseous needle. | This study was done, using a swine model of prolonged ventricular fibrillation out-of-hospital cardiac arrest, to determine the feasibility of inducing therapeutic hypothermia after successful resuscitation by giving an intraosseous infusion of iced saline.</AbstractText>This study was IACUC approved. Liter bags of nor... |
6,147 | Intranasal cooling with or without intravenous cold fluids during and after cardiac arrest in pigs. | Intranasal balloon catheters circulated with cold saline have previously been used for the induction and maintenance of selective brain cooling in pigs with normal circulation. In the present study, we investigated the feasibility of therapeutic hypothermia initiation, maintenance and rewarming using such intranasal ba... |
6,148 | Statins as antiarrhythmics: a systematic review part I: effects on risk of atrial fibrillation. | Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects.</AbstractText>Studies which reported the association of statins with the incidence of atrial arrhythmias were identified through a systematic review of published literature.</AbstractText>One... |
6,149 | Transcatheter closure of postsurgical residual ventricular septal defects: early and mid-term results. | The incidence of residual ventricular septal defects (VSDs) after surgery is 5-25%. Redo surgery is associated with higher risks.</AbstractText>Between January 2000 to December 2008, 170 patients underwent percutaneous VSD closure in our centre: 22(16M) of these had 23 closures for residual VSDs. Median age was 32.5 yr... |
6,150 | Antiarrhythmic and cardioprotective effects of remifentanil in anesthetized dogs. | To study the antiarrhythmic effect of remifentanil in experimental arrhythmias in dogs.</AbstractText>We used dogs weighing 12 kg-18 kg anesthetized with 30 mg/kg sodium pentobarbital given intravenously. Ventricular arrhythmia, ventricular fibrillation and death were induced with digoxin (9 microg/kg/min). In another ... |
6,151 | Preservation of neurological function following therapeutic hypothermia in a patient of in-hospital cardiac arrest with non-ventricular fibrillation. | A 76-year-old woman with a diagnosis of dilated-phase hypertrophic cardiomyopathy was admitted to our hospital for exacerbation of congestive heart failure. After admission, she developed cardiac arrest and the electrocardiogram showed pulseless electrical activity. Cardiopulmonary resuscitation was started immediately... |
6,152 | Defibrillation efficacy of a subcutaneous array lead: A case report. | We report a case of Brugada syndrome with a high defibrillation threshold (DFT) in whom a subcutaneous array lead was used to lower the DFT in combination with a transvenous right ventricular defibrillation lead. The patient had previously received pacemaker implantation due to sick sinus syndrome. An implantable cardi... |
6,153 | Inward rectifier potassium channels control rotor frequency in ventricular fibrillation. | Ventricular fibrillation (VF) is the most important cause of sudden cardiac death. While traditionally thought to result from random activation of the ventricles by multiple independent wavelets, recent evidence suggests that VF may be determined by the sustained activation of a relatively small number of reentrant sou... |
6,154 | Performance of a consensus scoring algorithm for assessing pediatric advanced life support competency using a computer screen-based simulator. | To develop a computer screen-based simulator that may be used as a pediatric advanced life support (PALS) cognitive skill assessment tool and to pilot test a consensus-based scoring system for the simulator.</AbstractText>Development of an evaluation tool, followed by prospective, observational study of tool performanc... |
6,155 | The influence of endotoxemia on the electroencephalographic and antinociceptive effects of isoflurane in a swine model. | We have previously reported that hemorrhagic shock decreases the minimum alveolar anesthetic concentration (MAC) of isoflurane but minimally alters the electroencephalographic (EEG) effect. In this study, we investigated the influence of endotoxemia on the EEG effect and the MAC of isoflurane.</AbstractText>Eighteen sw... |
6,156 | Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. | The ventricular action potential (AP) shortens exponentially upon a progressive reduction of the preceding diastolic interval. Steep electrical restitution slopes have been shown to promote wavebreaks, thus contributing to electrical instability. The present study was designed to assess the predictive value of electric... |
6,157 | Combined resynchronization therapy and automatic defibrillator in advanced non-ischaemic heart failure: the importance of QRS width. | The combined use of an automatic defibrillator in resynchronization therapy for primary prevention in patients with idiopathic dilated cardiomyopathy is controversial.</AbstractText>We assessed a series of 46 patients (61 +/- 10 years, 64% male) with idiopathic dilated cardiomyopathy undergoing resynchronization therap... |
6,158 | Biometal muscle to restore atrial transport function in a permanent atrial fibrillation animal model: a potential tool in the treatment of end-stage heart failure. | Half of the patients with end-stage heart failure suffer from persistent atrial fibrillation (AF). Atrial kick (AK) accounts for 10-15% of the ejection fraction. A device restoring AK should significantly improve cardiac output (CO) and possibly delay ventricular assist device (VAD) implantation. This study has been de... |
6,159 | Clinical, echocardiographic and histopathologic findings in nine patients with surgically explanted ASD/PFO devices: do we know enough about the healing process in humans? | Atrial septal defects (ASD) and persistent foramen ovale (PFO) are managed in increasing numbers by catheter interventions as an attractive alternative to surgery. Early complications have been described in clinical series whereas late complications are rare. No series are reported with clinical, echocardiographic and ... |
6,160 | Renal function and long-term survival after hospital discharge in heart failure with preserved ejection fraction. | Baseline renal function and worsening of renal function (WRF) during hospitalization for heart failure (HF) have a major prognostic impact in patients with left ventricular systolic dysfunction.</AbstractText>We sought to prospectively investigate the impact of reduced baseline renal function and WRF during hospitaliza... |
6,161 | Right ventricular rupture induced by cardiopulmonary resuscitation. | Right ventricular rupture is a rare complication of cardiopulmonary resuscitation and could be fatal. We report a survival case of right ventricular rupture induced by cardiopulmonary resuscitation in a patient with acute myocardial infarction. A 57-year-old man was admitted to our hospital with ventricular fibrillatio... |
6,162 | Induced moderate hypothermia after cardiac arrest. | The use of induced hypothermia has been considered for treatment of head injuries since the 1900s. However, it was not until 2 landmark studies were published in 2002 that induced hypothermia was considered best practice for patients after cardiac arrest. In 2005, the American Heart Association included recommendations... |
6,163 | Ability of terminal QRS notching to distinguish benign from malignant electrocardiographic forms of early repolarization. | Recent studies have suggested that early repolarization (ER) might be associated with up to 1/3 of idiopathic ventricular tachycardia/ventricular fibrillation (VT/VF) cases ("malignant" ER). We sought to identify electrocardiographic features to distinguish benign from malignant variants of ER. We reviewed the medical ... |
6,164 | The acute effect of Metoprolol upon NT-proBNP level in patients with congestive heart failure. | Brain natriuretic peptide (BNP) is a sensitive and specific marker of left ventricular (LV) function. The acute effect of beta blockers upon plasma BNP levels in CHF patients has been less studied but it is important because of the initial possible depressing effect upon LV function.</AbstractText>To investigate the ac... |
6,165 | Cardiac resynchronization therapy in heart failure patients with atrial fibrillation. | Cardiac resynchronization therapy (CRT) is an important device-based, non-pharmacological approach that has shown, in large randomized trials, to improve left ventricular (LV) function and reduce both morbidity and mortality rates in selected patients affected by advanced heart failure (HF): New York Heart Association ... |
6,166 | Dronedarone: a novel antiarrhythmic agent for the treatment of atrial fibrillation. | To describe the electrophysiological profile and the clinical portfolio of dronedarone, a new multichannel-blocking antiarrhythmic drug developed for the treatment of atrial fibrillation.</AbstractText>Dronedarone is a derivative of amiodarone that is free of iodine and less lipophilic. The drug has - as its predecesso... |
6,167 | Fragmented QRS and other depolarization abnormalities as a predictor of mortality and sudden cardiac death. | Several invasive and noninvasive tests for risk stratification of sudden cardiac death (SCD) have been studied. Tests such as microwave T wave alternans (repolarization abnormality) and signal-averaged ECG (depolarization abnormality) have high negative predictive values but low positive predictive values in patients w... |
6,168 | Left ventricular systolic dysfunction by itself does not influence outcome of atrial fibrillation ablation. | The objective of the study was to analyse the influence of left ventricular (LV) ejection fraction (EF) on the outcomes of atrial fibrillation (AF) ablation after a first procedure. Pre-procedural predictors of recurrences after AF ablation can be useful for patient information and selection of candidates. The independ... |
6,169 | Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs. Brugada syndrome. | The aim of the present study was to identify specific electrocardiogram (ECG) features that predict the development of multiple episodes of ventricular fibrillation (VF) in patients with an early repolarization (ER) pattern and to compare the mode of VF initiation with that observed in typical cases of Brugada syndrome... |
6,170 | Role of ischemic preconditioning and inflammatory response in the development of malignant ventricular arrhythmias after reperfused ST-elevation myocardial infarction. | Sustained ventricular tachycardia and ventricular fibrillation (VT/VF) are major complications of ST-elevation myocardial infarction (STEMI), even in the era of reperfusion therapy. We sought to clarify the determinants of VT/VF after reperfused STEMI.</AbstractText>Consecutive STEMI patients treated with primary percu... |
6,171 | Ventricular fibrillation by hypothermia in spinal fusion surgery: A case report. | A 63-year-old man was scheduled for T12-S1 posterolateral spinal fusion surgery. The patient's vital signs were stable and there were no specific laboratory findings except for high triglycerides. In addition, echocardiography showed mild left ventricular hypertrophy, but normal left ventricular function, no regional w... |
6,172 | A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation. | Myotonic dystrophy type 1 (MD1) is an autosomal dominant disorder characterized by myotonia, progressive muscular weakness, cataract, and cardiac involvement. Cardiac involvement is common and includes conduction system abnormalities, supraventricular and ventricular arrhythmias, and less frequently, myocardial dysfunc... |
6,173 | Tissue Doppler evaluation of the effects of major lung resection on cardiac functions. | The aim of our study was to evaluate the influence of lung resection on cardiac functions by using tissue Doppler echocardiography.</AbstractText>Nineteen consecutive patients (15 males, 4 females; mean age 55+/-8 years) undergoing major lung surgery (16 lobectomy, 3 pneumonectomy) were evaluated in a prospective desig... |
6,174 | Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. | Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention.</AbstractText>To analyze connexin changes and their potential contribution to the atrial fibrillat... |
6,175 | Triggering of nocturnal arrhythmias by sleep-disordered breathing events. | This study sought to evaluate respiratory disturbances as potential triggers for arrhythmia in patients with sleep-disordered breathing (SDB).</AbstractText>SDB is associated with an increased risk of atrial fibrillation and nonsustained ventricular tachycardia (NSVT) as well as a predilection for sudden cardiac death ... |
6,176 | Ventricular arrhythmia in coronary artery disease: limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization. | Estimates of the left ventricular ejection fraction (LVEF) in patients with life-threatening ventricular arrhythmias related to coronary artery disease (CAD) have rarely been reported despite it has become the basis for determining patient's eligibility for prophylactic defibrillator. We aimed to determine the extent a... |
6,177 | Incidence of paroxysmal atrial tachycardias in patients treated with cardiac resynchronization therapy and continuously monitored by device diagnostics. | Little is known about the incidence of paroxysmal atrial tachycardias (PAT) in patients with heart failure (HF). The availability of cardiac resynchronization therapy (CRT) devices with extended diagnostics for AT enables continuous monitoring of PAT episodes. The aim of the study was to assess the incidence over time ... |
6,178 | Thrombus formation due to flow competition after apico-aortic conduit. | We report a case of unusual thrombus formation and describe the risk of perioperative myocardial infarction or stroke in severe aortic stenosis after apico-aortic conduit. An 86-year-old woman was admitted with aggravation of dyspnoea on exertion and chest pain. She was complicated with severe aortic stenosis and liver... |
6,179 | Hypertension and atrial fibrillation. | Atrial fibrillation (AF) is an emerging public health problem. The most important risk factor for developing chronic AF is uncontrolled hypertension. Uncontrolled hypertension promotes the initiation and perpetuation of AF through atrial remodeling. Experimental evidence has demonstrated the important role of the renin... |
6,180 | The genetic basis of long QT and short QT syndromes: a mutation update. | Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization abnormalities that are characterized by length perturbations of the QT interval as measured on electrocardiogram (ECG). Prolonged QT interval and a propensity for ventricular tachycardia of the torsades de pointes (TdP) type are characteristic of... |
6,181 | A comparison between monophasic and biphasic defibrillation for the cardioversion of persistent atrial fibrillation in patients with and without heart failure. | Atrial fibrillation (AF) and heart failure commonly coexist. Restoring sinus rhythm using external direct current cardioversion (DCCV) may improve left ventricular function, exercise capacity and quality of life (QoL). However, DCCV may be less successful at restoring sinus rhythm in patients with heart failure. We aim... |
6,182 | Relationship of indices of inflammation and thrombogenesis to arrhythmia burden in paroxysmal atrial fibrillation. | Atrial fibrillation (AF) is associated with a high risk of stroke. The contribution of arrhythmia to events is clear in sustained forms of AF, but in paroxysmal AF, presently available data have yet to identify what proportion of time spent in AF (ie, arrhythmia burden [AFB]) is of clinical relevance. We aimed to asses... |
6,183 | Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. | Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear. This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective ... |
6,184 | Treatment and outcome of patients after cardiopulmonary resuscitation admitted to the intensive cardiac care unit. | Sudden circulatory arrest is most often of cardiac origin. Our aim was to evaluate circulatory arrest etiology and treatment strategies in patients after cardiopulmonary resuscitation (CPR) with persistent impairment of consciousness in relation to survival and the subsequent quality of life.</AbstractText>Retrospectiv... |
6,185 | Predictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial. | To determine whether predictors of sudden cardiac death (SCD) vary with time after myocardial infarction (MI).</AbstractText>We analysed 11 256 patients enrolled in VALIANT. Landmark analysis and Cox proportional hazards modelling were used to predict SCD during hospitalization, from discharge to 30 days, 30 days to 6 ... |
6,186 | Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity. | Episodes of ventricular fibrillation (VF) and myocardial dysfunction commonly occur after cardiac resuscitation compromising the return of stable circulation. We investigated in a pig model of VF whether limiting Na(+)-induced cytosolic Ca(2+) overload using the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) i... |
6,187 | Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals. | We hypothesized that patients most likely to benefit would be those at high risk with a shorter duration of acute ischemia and who required transfer for percutaneous coronary intervention (PCI).</AbstractText>The FINESSE (Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events) study failed to demonstra... |
6,188 | The utility of transoesophageal echocardiography to determine management in suspected embolic stroke. | Assessment for source of stroke is a common indication for transoesophageal echocardiography (TOE). Although an abnormality is frequently found, it remains uncertain how frequently the findings alter patient management. Also, the role of transthoracic echocardiography (TTE) prior to or instead of TOE is not well define... |
6,189 | Prime time use of tissue Doppler echocardiography: what have we gained? | In daily practice, Tissue Doppler Echocardiography (TDI) is used to estimate left ventricular filling pressures, categorize diastolic dysfunction, identify patients with heart failure (HF) with normal ejection fraction, differentiate constrictive pericarditis from restrictive cardiomyopathy, to prognosticate acute coro... |
6,190 | Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel. | A prerequisite for a normal cardiac function is a proper generation and propagation of electrical impulses. Contraction of the heart is obtained through a delicate matched transmission of the electrical impulses. A pivotal element of the impulse propagation is the depolarizing sodium current, responsible for the initia... |
6,191 | Limited response to cardiac resynchronization therapy in patients with concomitant right ventricular dysfunction. | Patients with left ventricular dysfunction (LVD) and LV dyssynchrony may respond to cardiac resynchronization therapy (CRT). However, right ventricular dysfunction (RVD) is a predictor of decreased survival in patients with LVD, and its influence on clinical response to CRT is unknown. The purpose of this study was to ... |
6,192 | Identification of hemodynamically unstable arrhythmias using subcutaneous photoplethysmography. | Determination of hemodynamic status is central to arrhythmia management in the inpatient setting. In contrast, therapy decisions in implantable cardioverter defibrillators (ICDs) are based exclusively on the arrhythmia's electrical signature. Hemodynamic sensing in ICDs would allow tailoring of therapy according to per... |
6,193 | Automatic detection and classification of human epicardial atrial unipolar electrograms. | This paper describes an unsupervised signal processing method applied to three-channel unipolar electrograms recorded from human atria. These were obtained by epicardial wires sutured on the right and left atria after coronary artery bypass surgery. Atrial (A) and ventricular (V) activations had to be detected and iden... |
6,194 | Short-term memory and restitution during ventricular fibrillation in human hearts: an in vivo study. | Action potential duration (APD) variation is an important determinant of wave break and reentry. The determinants of APD variability during early ventricular fibrillation (VF) in myopathic human hearts have not been studied. The objective of this study was to study the role of APD restitution and short-term cardiac mem... |
6,195 | Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3. | The prognosis of patients with saddleback or noncoved type (non-type 1) ST-elevation in Brugada syndrome is unknown. The purpose of this study was to clarify the long-term prognosis of probands with non-type 1 ECG and those with coved (type 1) Brugada-pattern ECG.</AbstractText>A total of 330 (123 symptomatic, 207 asym... |
6,196 | Relationship of paroxysmal atrial tachyarrhythmias to volume overload: assessment by implanted transpulmonary impedance monitoring. | Clinical experience suggests that atrial tachyarrhythmias (ATs) are a frequent comorbidity in heart failure patients with left ventricular systolic dysfunction and that volume overload may increase AT susceptibility. However, substantiating this apparent relationship in free-living patients is difficult. Recently, cert... |
6,197 | Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. | Xin is a striated muscle-specific F-actin binding protein that has been implicated in cardiomyopathies. In cardiomyocytes, Xin is localized at intercalated discs (IDs). Mice lacking only two of the three Xin isoforms (XinAB(-/-) mice) develop severe cardiac hypertrophy. To further investigate the function of Xin varian... |
6,198 | Role of transesophageal echocardiography among patients with atrial fibrillation undergoing electrophysiology testing. | External or internal shocks administered to terminate ventricular arrhythmias as a part of electrophysiology or implantable cardioverter-defibrillator testing, can inadvertently cardiovert atrial fibrillation (AF). Moreover, anticoagulation therapy is often withheld in these patients in anticipation of an invasive proc... |
6,199 | Predictors of the atrial fibrillation occurrence in patients with Wolff-Parkinson-White syndrome. | Atrial fibrillation (AF) in WPW syndrome occurs earlier and is more common than in the general population.</AbstractText>To evaluate the predisposing factors for the first episode of AF in patients with WPW.</AbstractText>We analysed data on 930 patients (510 males, 420 females) with WPW treated in our centre during 19... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.