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6,800 | Wolff-Parkinson-White syndrome: where is the pathway? | A 31-year old male presented with atrial fibrillation and ventricular preexcitation that was positive in leads V1-V4, negative in lead II, and positive in lead AVR. The patient was cardioverted and invasive electrophysiologic study was performed. Based on the ECG findings, the coronary sinus and its branches were inter... |
6,801 | Dominant frequency differences in atrial fibrillation patients with and without left ventricular systolic dysfunction. | The aim of this study was to determine the mechanisms of atrial fibrillation (AF) in patients with left ventricular systolic dysfunction (LVSD).</AbstractText>Dominant frequency (DF) spatiotemporal stability was studied in 15 patients with persistent AF (PEAF) and LVSD (Group I), 15 with PEAF without LVSD (Group II), a... |
6,802 | A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation. | Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF. In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF as... |
6,803 | The utility of 12-lead Holter monitoring in patients with permanent atrial fibrillation for the identification of nonresponders after cardiac resynchronization therapy. | This study sought to determine the incidence of ineffective capture using 12-lead Holter monitoring and to assess whether this affects response to cardiac resynchronization therapy (CRT).</AbstractText>Cardiac resynchronization therapy is used in patients with atrial fibrillation (AF), prolonged QRS duration, and heart... |
6,804 | Robotic catheter ablation of ventricular tachycardia in a patient with congenital heart disease and Rastelli repair. | Robotically assisted catheter ablation has been proven feasible in patients with a variety of atrial arrhythmias. The potential to provide improved catheter tip maneuvering and stability potentially makes it ideal for complex ablation procedures. We present the case of a patient with complex congenital heart disease wi... |
6,805 | Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. | In vitro studies and ambulatory ECG recordings from the MERLIN TIMI-36 clinical trial suggest that the novel antianginal agent ranolazine may have the potential to suppress atrial arrhythmias. However, there are no reports of effects of ranolazine on atrial electrophysiologic properties in large intact animals.</Abstra... |
6,806 | Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve preparations. | To examine the effects of chronic amiodarone on the electrophysiology of canine pulmonary vein (PV) sleeve preparations and left ventricular wedge preparation.</AbstractText>Amiodarone is commonly used for the treatment of ventricular and supraventricular arrhythmias. Ectopic activity arising from the PV plays a promin... |
6,807 | [A case of acalcuous cholecystitis developed after cardiopulmonary resuscitation]. | A 47-year-old man was found at his home in a state of cardiopulmonary arrest. His family performed cardiopulmonary resuscitation on him. He was brought to our hospital by ambulance. On arrival, his pupils were dilated and his heart was in a state of ventricular fibrillation. After returning to spontaneous circulation b... |
6,808 | When should serum magnesium be measured prior to non-cardiac surgery? | While prospective data is scant, the advisability of magnesium measurement appears to be convincing in selected circumstances. Electrolyte abnormalities, mainly hypokalemia and hypomagnesemia, are associated with an increased risk for developing cardiac arrhythmias, however, conflicting opinions remain. If performed on... |
6,809 | Guideline for resuscitation in cardiac arrest after cardiac surgery. | The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation including the extrapolation of existing guidelines from the... |
6,810 | Ca2+: is there something new for the cardiovascular anesthesiologist? | Anesthesiologists are frequently called upon to treat abnormalities of heart rhythm or pumping ability. Intracellular Ca is crucial for normal excitation-contraction coupling in the heart and plays a major role in the sequence of events that starts with an electrical signal generated in the atria and ends with myocardi... |
6,811 | [Brugada syndrome--underestimated cause of sudden cardiac death in patients without an organic cardiac disease--a case report]. | We present a case of a 61-year-old man with a history of syncope and sudden cardiac arrest due to ventricular fibrillation, with the symptoms of spontaneous electrocardiographic changes characteristic for the Brugada syndrome. The patient received an implantable cardioverter-defibrillator. This patient was previously h... |
6,812 | Mechanical cardiac remodeling and new-onset atrial fibrillation in long-term follow-up of subjects with chronic Chagas' disease. | Atrial fibrillation (AF) affects subjects with Chagas' disease and is an indicator of poor prognosis. We investigated clinical, echocardiographic and electrocardiographic variables of Chagas' disease in a long-term longitudinal study as predictors of a new-onset AF episode lasting >24 h, nonfatal embolic stroke and ... |
6,813 | Recognition and management of complex rhythm disorders in heterotopic heart transplantation. | Managing arrhythmias is challenging in patients who have undergone heterotopic heart transplantation because of the superimposed rhythms of the native and donor hearts. We present the case of a 43-year-old man with a previously placed biventricular pacemaker who underwent heterotopic heart transplantation and later dev... |
6,814 | Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. | Idiopathic Ventricular Fibrillation (IVF) is defined as spontaneous VF without any known structural or electrical heart disease. A family history is present in up to 20% of probands with the disorder, suggesting that at least a subset of IVF is hereditary. A genome-wide haplotype-sharing analysis was performed for iden... |
6,815 | Ventricular fibrillation in acute mitral valve insufficiency caused by chordae tendineae rupture: report of a surgically corrected case. | In this report, we present the case of a previously healthy 80-year-old woman who was referred to surgery after a cardiac arrest due to ventricular fibrillation successfully resuscitated; the following evaluation revealed acute mitral regurgitation due to chordae tendineae rupture. After mitral valve repair, a single-c... |
6,816 | A randomised, controlled study of rate versus rhythm control in patients with chronic atrial fibrillation and heart failure: (CAFE-II Study). | Atrial fibrillation (AF) and heart failure (HF) often coexist. The aim was to investigate whether restoring sinus rhythm (SR) could improve cardiac function, symptoms, exercise capacity and quality of life (QoL) in patients with chronic heart failure.</AbstractText>Patients with HF and persistent AF receiving guideline... |
6,817 | Heart failure with normal left ventricular ejection fraction. | It is estimated that approximately 50% of the heart failure population has a normal left ventricular ejection fraction, a complex broadly referred to as heart failure with normal left ventricular ejection fraction (HFNEF). While these patients have been considered in epidemiologic studies and clinical trials to represe... |
6,818 | Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart. | The zebrafish (Danio rerio) is an emerging model for cardiovascular research. The zebrafish heart regenerates after 20% ventricular amputation. However, assessment of the physiological responses during heart regeneration has been hampered by the small size of the heart and the necessity of conducting experiments in an ... |
6,819 | Predictors of early mortality in implantable cardioverter-defibrillator recipients. | Multiple trials have shown that implantable cardioverter defibrillators (ICDs) prolong survival in secondary and primary prevention populations. However, in spite of the efficacy of these devices in terminating life-threatening arrhythmias, total mortality remains high.</AbstractText>We evaluated 1703 patients (mean ag... |
6,820 | Pharmacological therapy for atrial fibrillation: current options and new agents. | Atrial fibrillation is the most commonly encountered cardiac arrhythmia and is directly or indirectly responsible for considerable mortality, morbidity and health care burden. The available medical therapy is limited by marginal efficacy, end-organ toxicity, as well as the potential for undesired ventricular proarrhyth... |
6,821 | Epidemiology and outcomes from out-of-hospital cardiac arrest in children: the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest. | Population-based data for pediatric cardiac arrest are scant and largely from urban areas. The Resuscitation Outcomes Consortium (ROC) Epistry-Cardiac Arrest is a population-based emergency medical services registry of out-of-hospital nontraumatic cardiac arrest (OHCA). This study examined age-stratified incidence and ... |
6,822 | Poincaré surface profiles of RR intervals: a novel noninvasive method for the evaluation of preferential AV nodal conduction during atrial fibrillation. | The ventricular response during atrial fibrillation (AF) presents particular characteristics that may play a relevant role in the selection of the most appropriate treatment. Using different ECG signal processing techniques such as RR histogram analysis or histographic Poincaré plots (PPs) (so-called 3-D PPs), clu... |
6,823 | Spatiotemporal frequency analysis of ventricular fibrillation in explanted human hearts. | Ventricular fibrillation (VF) is a medical condition that occurs due to rapid and irregular electrical activity of heart. If undiagnosed or untreated, VF leads to sudden cardiac death. VF has been studied by researchers for over 100 years to elucidate the mechanism that maintains VF, and thus to arrive at therapeutic o... |
6,824 | Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutations. | The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The molecular and cellular mechanisms that lead to Brugada syndrome are not yet completely understood. However, SCN5A ... |
6,825 | Unusual cause of recurrent syncope in a child. | A 5-year-old boy with an unremarkable past medical and family history presented with recurrent syncope precipitated by physical activity. Electrocardiogram performed in the emergency room after one of his episodes revealed atrial flutter. He had a structurally normal heart. Exercise stress test revealed atrial fibrilla... |
6,826 | Ventricular fibrillation triggered during and after radiofrequency energy delivery to the site of origin of idiopathic right ventricular outflow tract arrhythmia. | We observed a case of idiopathic ventricular arrhythmias originating from the right ventricular outflow tract (RVOT). The origin of target premature ventricular contraction (PVC) and nonsustained ventricular tachycardia (VT) was within a wide low-voltage area around the RVOT. During radiofrequency (RF) application to t... |
6,827 | Excellent long-term reproducibility of the electrophysiologic efficacy of quinidine in patients with idiopathic ventricular fibrillation and Brugada syndrome. | Quinidine is very effective in preventing the reinduction of sustained ventricular fibrillation (VF) during electrophysiologic study (EPS) in patients with idiopathic VF and Brugada syndrome. However, there are no data on the long-term reproducibility of this EP efficacy.</AbstractText>Nine patients (seven males and tw... |
6,828 | Role of left ventricular scar and Purkinje-like potentials during mapping and ablation of ventricular fibrillation in dilated cardiomyopathy. | Purkinje-like potentials (PLPs) have been described as important contributors to initiation of ventricular fibrillation (VF) in patients with normal hearts, ischemic cardiomyopathy, and early after-myocardial infarction.</AbstractText>Of the 11 consecutive patients with VF storm, nonischemic cardiomyopathy (68 +/- 22 y... |
6,829 | Fragmented QRS: a predictor of mortality and sudden cardiac death. | Several invasive and noninvasive tests for risk stratification of sudden cardiac death have been studied, mostly in the context of structural heart disease such as coronary artery disease (CAD), cardiomyopathy, and heart failure. Tests such as MTWA (repolarization abnormality) and SAECG (depolarization abnormality) hav... |
6,830 | Analysis of 57,148 transmissions by remote monitoring of implantable cardioverter defibrillators. | Remote monitoring of implantable cardioverter defibrillators (ICD) is designed to decrease the number of ambulatory visits and facilitate the early detection of adverse events. We examined the impact of remote monitoring on clinical workload by a comprehensive analysis of transmitted events.</AbstractText>The study pop... |
6,831 | Impact of AV conduction disorders on SafeR mode performance. | CAN-SAVE R is a Canadian multicenter study that compares the effects of a new pacing mode algorithm designed to minimize right ventricular (V) pacing versus DDD mode with a long atrioventricular (AV) delay in a general population of pacemaker (PM) recipients.</AbstractText>Patients with permanent atrial fibrillation (A... |
6,832 | Coronary blood flow produced by muscle contractions induced by intracardiac electrical CPR during ventricular fibrillation. | It has been reported that transthoracic electrical cardiopulmonary resuscitation (ECPR) generates coronary perfusion pressures (CPP) similar to manual chest compressions (MCC). We hypothesized that intracardiac ECPR produces similar CPP.</AbstractText>ECPR pulse train protocols were applied for 20 seconds in a porcine ... |
6,833 | Spiral-wave turbulence and its control in the presence of inhomogeneities in four mathematical models of cardiac tissue. | Regular electrical activation waves in cardiac tissue lead to the rhythmic contraction and expansion of the heart that ensures blood supply to the whole body. Irregularities in the propagation of these activation waves can result in cardiac arrhythmias, like ventricular tachycardia (VT) and ventricular fibrillation (VF... |
6,834 | Relationship between left atrial size and stroke in patients with sinus rhythm and preserved systolic function. | <AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">Increased left atrial (LA) size has been proposed as a predictor of poor cardiovascular outcome in the elderly. In the present study, we evaluated the relationship between LA size and stroke in subjects of all ages who presented with preserved left ventricul... |
6,835 | Towards predictive modelling of the electrophysiology of the heart. | The simulation of cardiac electrical function is an example of a successful integrative multiscale modelling approach that is directly relevant to human disease. Today we stand at the threshold of a new era, in which anatomically detailed, tomographically reconstructed models are being developed that integrate from the... |
6,836 | Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. | Patients with paroxysmal atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non ST-segment elevation myocardial infarction) during an arrhythmic event. However, in a large proportion of these patients, significant coronary artery disease is excluded by co... |
6,837 | Intramural left atrial haematoma mimicking cardiac tamponade after catheter ablation of atrial fibrillation. | Catheter ablation is an established treatment modality for patients with drug refractory atrial fibrillation (AF). This procedure carries a 6% major complication rate including cardiac tamponade due to cardiac perforation. We report on a patient with clinical signs of cardiac tamponade due to a diffuse intramural left ... |
6,838 | Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives. | Congenital long-QT syndrome (LQTS) is a sporadic or familial inherited arrhythmia. It can lead to sudden death by ventricular fibrillation which occurs at any age but particularly during infancy. Recent studies of postmortem molecular analysis in infants who died of unexplained sudden infant death syndrome (SIDS) showe... |
6,839 | The conundrum of ventricular arrhythmia and cardiomyopathy: which abnormality came first? | Ventricular arrhythmia and cardiomyopathy often coexist. Many patients with abnormal ventricular function have either documented premature ventricular contractions (PVCs) or nonsustained ventricular tachycardia and have an increased risk of sudden death from ventricular fibrillation. Tachycardia is a treatable cause of... |
6,840 | The DAVID (Dual Chamber and VVI Implantable Defibrillator) II trial. | The purpose of this study was to determine whether atrial pacing is a safe alternative to minimal (backup-only) ventricular pacing in defibrillator recipients with impaired ventricular function.</AbstractText>The DAVID (Dual Chamber and VVI Implantable Defibrillator) trial demonstrated that dual chamber rate responsive... |
6,841 | Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients. | Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants... |
6,842 | Defibrillation in clinical practice. | To discuss recent data that may influence defibrillation in clinical practice and improve outcome after cardiac arrest from a shockable rhythm.</AbstractText>Reducing the preshock pause (interval between stopping chest compressions and shock delivery) improves shock success. The preshock pause can be reduced by continu... |
6,843 | Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest. | The pathogenesis of out-of-hospital cardiac arrest (OHCA) without organic heart disease has not been fully investigated.</AbstractText>Induction tests were performed in 12 consecutive patients with OHCA for both coronary vasospasm with intracoronary acetylcholine and ventricular fibrillation (VF) with programmed stimul... |
6,844 | Autonomic elements within the ligament of Marshall and inferior left ganglionated plexus mediate functions of the atrial neural network. | We sought to systematically investigate the role of the ligament of Marshall (LOM) and inferior left ganglionated plexi (ILGP) in modulating electrophysiological functions.</AbstractText>The following structures were exposed in 36 dogs: (1) LOM, (2) superior left GP (SLGP) near the junction of left superior pulmonary v... |
6,845 | Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index. | To investigate association between the Tei index and cardiac complications of ST elevation of Myocardial Infarction.</AbstractText>A total of a 202 adult consecutive patients with first ST elevation MI (STEMI) were studied. Tei index was obtained as: (a _ b)/b, where "a" is the interval between the cessation and onset ... |
6,846 | Implantable cardioverter-defibrillator implantation in a patient with atrial standstill. | We report a 55-year-old female patient who presented with no P waves but with a wide QRS complex escape rhythm at 44 beats/min and prolonged QTc of 0.55 seconds on ECG. The patient had recurrence of ventricular fibrillations and loss of consciousness, and underwent defibrillation and cardiopulmonary resuscitation (CPR)... |
6,847 | Wireless cardiac event alert monitoring is feasible and effective in the emergency department and adjacent waiting areas. | The need for vigilance for unexpected clinical deterioration in the emergency department (ED) waiting area and in unmonitored treatment areas of the ED continues to increase. We sought to determine in an observational study the feasibility and relative false-alarm burden of, and satisfaction with, a novel wireless auto... |
6,848 | [Cardiac autotransplantation in a patient with congestive heart failure]. | Congestive heart failure with intact or moderately lowered left ventricular pump function is caused in some patients by mitral regurgitation. Consequences are dilation of the left atrium, pulmonary hypertension, tricuspid regurgitation, thromboembolic complications, rhythm disturbances, elevated risk of sudden death. E... |
6,849 | Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. | Cardiac hypertrophy, the clinical hallmark of hypertrophic cardiomyopathy (HCM), is a major determinant of morbidity and mortality not only in HCM but also in a number of cardiovascular diseases. There is no effective therapy for HCM and generally for cardiac hypertrophy. Myocardial oxidative stress and thiol-sensitive... |
6,850 | [Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension]. | Aim of the study--investigation of dynamics of levels of serum markers of myocardial fibrosis matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1)--at the background of 3 months hypotensive therapy in 39 patients with arterial hypertension and paroxysmal form of atrial fibrillatio... |
6,851 | [Wolf-Parkinson-White syndrome: stratification of syncope risk factors]. | To evaluate risk factors of syncopes in patients with Wolf-Parkinson-White syndrome (WPWS) using transesophageal pacing (TEP).</AbstractText>82 WPWS patients were divided into two groups: the study group (n = 46) with syncopes and presyncopes, the control group (n = 36) without syncopes. The groups were matched by sex ... |
6,852 | [Pacemaker implantation in a patient with cor triatriatum sinister - preoperative evaluation]. | A case of 72 year old-male with cor triatriatum sinister, permanent atrial fibrillation and symptomatic bradycardia is presented. Patient was scheduled for pacemaker implantation. A preoperative evaluation with transesophageal echocardiography revealed a nonrestrictive membrane in left atrium, normal right superior ven... |
6,853 | Ventricular tachycardia and sudden cardiac death. | Ventricular tachycardia (VT), which most commonly occurs in patients with structural heart disease, can be associated with an increased risk of sudden death. The most common cause of ventricular fibrillation is acute coronary ischemia, whereas a myocardial scar from prior infarct is the most common cause of sustained m... |
6,854 | Mechanisms of VF maintenance: wandering wavelets, mother rotors, or foci. | Ventricular fibrillation (VF), despite its declining incidence as a cause of sudden cardiac death, is still a major health problem. The underlying mechanisms for the maintenance of VF are still disputed. Studies suggest that VF is unlikely one static mechanism but rather a dynamic process of electrical derangement that... |
6,855 | Increased cycle length during long-duration ventricular fibrillation is caused by decreased upstroke velocity as well as prolonged refractoriness. | Cycle length (CL) increases as ventricular fibrillation (VF) progresses.</AbstractText>The purpose of this study was to test the hypotheses that increased CL is due to increased diastolic interval (DI), not increased action potential duration (APD), and that the DI increase is not solely due to increased postrepolariza... |
6,856 | Clinical importance of new-onset atrial fibrillation after cardiac resynchronization therapy. | Data on the occurrence and implications of new-onset atrial fibrillation (AF) following cardiac resynchronization therapy (CRT) are scarce. We studied the incidence of new onset AF in CRT-defibrillator (CRT-D) recipients. The influence of new-onset AF on echocardiographic response to CRT and the rate of adverse events ... |
6,857 | Computer simulation of atypical Brugada syndrome. | Recently, the so-called atypical Brugada syndrome (BS) has been reported in few cases in literature. The typical BS is characterized by ST-segment elevation in the right precordial leads, whereas atypical forms of the disease are distinguished by electrocardiogram abnormalities of the J wave, and ST-segment elevation a... |
6,858 | Intra-arrest hypothermia: both cold liquid ventilation with perfluorocarbons and cold intravenous saline rapidly achieve hypothermia, but only cold liquid ventilation improves resumption of spontaneous circulation. | Rapid intra-arrest induction of hypothermia using total liquid ventilation (TLV) with cold perfluorocarbons improves resuscitation outcome from ventricular fibrillation (VF). Cold saline intravenous infusion during cardiopulmonary resuscitation (CPR) is a simpler method of inducing hypothermia. We compared these 2 meth... |
6,859 | Quinidine revisited. | One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for increased risk of ventricular arrhythmia and death with quinidine emerged, the use of quinidine fell dramatically in favor of newer antiarrhythmic medications. However, recent tr... |
6,860 | [Prevalence of left ventricular hypertrophy, atrial fibrillation and cardiovascular disease in hypertensive patients of Andalusia, Spain. PREHVIA study]. | The objective of the PREHVIA study was to assess the prevalence of electrocardiographic left ventricular hypertrophy (ECG-LVH) and of atrial fibrillation (AF) among Andalusian hypertensive patients, and the relationship of this complications with cardiovascular disease (CVD).</AbstractText>Cross-sectional study with se... |
6,861 | Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice. | Connexin (Cx) 30.2, Cx40 and Cx45 containing gap junctional channels contribute to electrical impulse propagation through the mouse atrioventricular node (AV-node). The cross talk in between these Cxs may be of great importance for AV-nodal conduction. We generated Cx30.2/Cx40 double deficient mice (Cx30.2(LacZ/LacZ)Cx... |
6,862 | Mitral valve disease in pregnancy: outcomes and management. | Young women may have asymptomatic mitral valve disease which becomes unmasked during the haemodynamic stress of pregnancy. Rheumatic mitral stenosis is the most common cardiac disease found in women during pregnancy. The typical increased volume and heart rate of pregnancy are not well tolerated in patients with more t... |
6,863 | Therapeutical hypothermia after cardiopulmonary resuscitation: evidences and practical issues. | Cardiac arrest survivors frequently suffer from ischemic brain injury associated with poor neurological outcome and death. Therapeutic hypothermia improves outcomes in comatose survivors after resuscitation from out-of-hospital cardiac arrest. Considering its formal recommendation as a therapy, post-return of spontaneo... |
6,864 | Autoimmune mechanisms underlying dilated cardiomyopathy. | Autoimmune abnormalities, as well as viral infection and genetic abnormalities, appear to be major predisposing factors for dilated cardiomyopathy (DCM). Abnormalities of cell-mediated immunity are mainly involved in the onset of cardiomyopathy secondary to myocarditis. However, various antimyocardial antibodies are de... |
6,865 | The emerging role of antiarrhythmic compounds with atrial selectivity in the management of atrial fibrillation. | Atrial fibrillation represents a significant source of cardiovascular morbidity and mortality in the United States. Despite a relatively high clinical failure rate, pharmacologic conversion to and maintenance of normal sinus rhythm with antagonists of the HERG potassium channel responsible for carrying the delayed rect... |
6,866 | Bioequivalence of 2 intravenous amiodarone formulations in healthy participants. | Intravenous amiodarone is an effective agent for the treatment of recurrent ventricular fibrillation and hemodynamically unstable ventricular tachycardia. PM101 is a new formulation of intravenous amiodarone that uses a cyclodextrin to maintain amiodarone in the aqueous phase. Eighty-eight participants were enrolled in... |
6,867 | Diagnostic accuracy and image quality of cardiac dual-source computed tomography in patients with arrhythmia. | Cardiac multi-detector computed tomography (MDCT) permits accurate visualization of high-grade coronary artery stenosis. However, in patients with heart rate irregularities, MDCT was found to have limitations. Thus, the aim of the present study was to evaluate the diagnostic accuracy of a new dual-source computed tomog... |
6,868 | Anger-induced T-wave alternans predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators. | This study sought to determine whether T-wave alternans (TWA) induced by anger in a laboratory setting predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators (ICDs).</AbstractText>Anger can precipitate spontaneous ventricular tachycardia/ventricular fibrillation and induce TWA.... |
6,869 | [CRT in atrial fibrillation--methodical and apparatus options in decision-making]. | Heart failure and atrial fibrillation often coexist, especially with increasing degree of heart failure severity. Under this constellation, the advantage of cardiac resynchronization therapy (CRT) is still under discussion and displayed as an unresolved problem in the guidelines for cardiac stimulation and resynchroniz... |
6,870 | [Sandwiched between the single- and triple-chamber ICD: do we still need the dual-chamber ICD?]. | Since it has been shown that adverse events are more frequent with dual-compared to single-chamber ICDs in patients with heart failure, and since the importance of prevention of unnecessary right ventricular pacing and the success of biventricular pacing have been demonstrated in numerous studies, the need for dual-cha... |
6,871 | Scandinavian clinical practice guidelines for therapeutic hypothermia and post-resuscitation care after cardiac arrest. | Sudden cardiac arrest survivors suffer from ischaemic brain injury that may lead to poor neurological outcome and death. The reperfusion injury that occurs is associated with damaging biochemical reactions, which are suppressed by mild therapeutic hypothermia (MTH). In several studies MTH has been proven to be safe, wi... |
6,872 | Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation. | Epinephrine has been the primary drug for cardiopulmonary resuscitation (CPR) for more than a century. The therapeutic rationale was to restore threshold levels of myocardial and cerebral blood flows by its alpha1 (alpha1) and alpha2 (alpha2)-adrenergic agonist vasopressor actions. On the basis of coincidental observat... |
6,873 | Percutaneous left ventricular assist in ischemic cardiac arrest. | Ischemic cardiac arrest represents a challenge for optimal emergency revascularization therapy. A percutaneous left ventricular assist device (LVAD) may be beneficial.</AbstractText>To determine the effect of a percutaneous LVAD during cardiac arrest without chest compressions and to assess the effect of fluid loading.... |
6,874 | A minimally invasive method for induction of myocardial infarction in an animal model using tungsten spirals. | Most animal models use surgical thoracotomy with ligation of a coronary artery to induce myocardial infarction. Incision of the chest wall and myocardium affect remodeling after myocardial infarction. The aim of our study was to evaluate a new minimally invasive technique for inducing acute myocardial infarction in pig... |
6,875 | The MUSIC Risk score: a simple method for predicting mortality in ambulatory patients with chronic heart failure. | The prognosis of chronic heart failure (CHF) is extremely variable, although generally poor. The purpose of this study was to develop prognostic models for CHF patients.</AbstractText>A cohort of 992 consecutive ambulatory CHF patients was prospectively followed for a median of 44 months. Multivariable Cox models were ... |
6,876 | Modulation of gap junctions by nitric oxide contributes to the anti-arrhythmic effect of sodium nitroprusside? | Nitric oxide (NO) donors provide a preconditioning-like anti-arrhythmic protection in the anaesthetized dog. As NO may modulate gap junction (GJ) function, the present study investigated whether this anti-arrhythmic effect is due to a modification of GJs by NO, derived from the NO donor sodium nitroprusside (SNP).</Abs... |
6,877 | Improved outcomes of cardiopulmonary resuscitation in rats with myocardial infarction treated with allogenic bone marrow mesenchymal stem cells. | We hypothesized that rats in which myocardial infarction had been treated with mesenchymal stem cells (MSCs) would have better outcomes following the global myocardial ischemia of cardiac arrest and cardiopulmonary resuscitation (CPR) compared with rats in which myocardial infarction had been treated with phosphate buf... |
6,878 | Usefulness of body surface potential mapping for early identification of the intraventricular conduction disorders in young patients with chronic kidney disease. | Cardiovascular complications are considered a significant problem in patients with chronic kidney disease (CKD). Body surface potential mapping (BSPM) is a noninvasive method that is useful in detecting early changes involving the heart. The aim of the study was to evaluate possible abnormalities within the cardiac int... |
6,879 | Electrophysiologic changes in heart failure: focus on pacemaker channels. | Heart failure is a common clinical syndrome occurring as a result of cardiac overload, injury, and a complex interplay among genetic, neurohormonal, inflammatory, and biochemical factors. Occurrence of arrhythmias in heart failure is largely a consequence of disease-induced electrical remodeling of cardiac myocytes, a ... |
6,880 | Transient outward potassium channel regulation in healthy and diabetic hearts. | Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolarizi... |
6,881 | Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction. | We have previously reported that postresuscitation myocardial dysfunction is accompanied by the release of cytochrome c and caspase-3 activation. We now investigated the role of caspase-3 activation by examining whether such process prompts apoptotic DNA fragmentation, whether caspase-3 inhibition attenuates myocardial... |
6,882 | Assessment of nonlinear heart rate dynamics after beating-heart revascularization. | Advanced nonlinear methods of measuring heart rate variability (HRV) derived from the mathematics of complex dynamics and fractal geometry have provided new insights into the abnormalities of heart rate behavior in various pathologic conditions. These methods have provided additional prognostic information compared wit... |
6,883 | A disappearing left atrial thrombus. | The authors report a case of a migrating left atrial thrombus identified under direct visualization using transthoracic echocardiography in an elderly patient with atrial fibrillation. The left atrial-ventricular-aortic course of the thrombus was observed in real time, and prompt diagnosis and treatment of an acute car... |
6,884 | [Trends in cardiopulmonary resuscitation]. | Less than 10% of those individuals who suffer an episode of sudden cardiac arrest are successfully resuscitated and return home to live productive lives. New approaches to cardiac resuscitation could substantially improve such dismal outcome. Four current trends that have the greatest potential for improving outcome ca... |
6,885 | Magnesium sulphate and amiodarone prophylaxis for prevention of postoperative arrhythmia in coronary by-pass operations. | The aim of this study was to investigate the use of prophylactic magnesium sulphate and amiodarone in treating arrhythmias that may occur following coronary bypass grafting operations.</AbstractText>The study population consisted of 192 consecutive patients who were undergoing coronary artery bypass grafting (CABG). Si... |
6,886 | Minimally invasive mitral valve surgery after previous sternotomy: experience in 181 patients. | This study evaluated the results for minimally invasive mitral valve (MV) surgery in patients who had undergone previous cardiac operations through a sternotomy.</AbstractText>From March 1, 1999 to January 2008, minimally invasive MV reoperations were performed in 181 consecutive patients (110 men) with a mean age of 6... |
6,887 | Anesthetic management of percutaneous aortic valve implantation: focus on challenges encountered and proposed solutions. | To describe 6 months of experience in the anesthetic management of percutaneous aortic valve implantation.</AbstractText>An observational, cohort study.</AbstractText>A university hospital.</AbstractText>Eighteen high-risk patients with relative contraindications to surgical valve replacement (78 +/- 8.7 years, logisti... |
6,888 | Incremental predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide for short-term recurrence in atrial fibrillation ablation. | The objective of this work was to assess the predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients undergoing atrial fibrillation (AF) ablation. Seventy-three consecutive patients with AF (paroxysmal n = 49, persistent n = 24) and preserved left ventricular (LV) sys... |
6,889 | Development and characterization of a mouse in vitro model of ischaemia-induced ventricular fibrillation. | We sought to generate a mouse Langendorff model of ischaemia-induced ventricular fibrillation (VF) that does not depend on triggers such as programmed electrical stimulation.</AbstractText>Hearts from male Tuck Ordinary mice were perfused with Krebs solution (modified to contain low-normal K(+), 3 mmol/L, and high Ca(2... |
6,890 | Percutaneous catheter ablation of arrhythmias in children. | Supraventricular tachycardias (SVTs) are the most common arrhythmias in children, with Wolff-Parkinson-White (WPW) syndrome the most prevalent entity. Percutaneous catheter ablation is now the standard of care for SVT in pediatric patients, although specific techniques are required due to their age.</AbstractText>To ev... |
6,891 | Impact of atrial fibrillation in acute coronary syndromes. | Atrial fibrillation (AF) is a relatively common arrhythmia in the context of acute coronary syndromes (ACS). However, the impact of AF on these patients' survival is not well established. The present study aimed to estimate the prevalence of AF in ACS patients and to evaluate its impact on in-hospital and six-month pos... |
6,892 | The incidence and risk factors of arrhythmias in the early period after cardiac surgery in pediatric patients. | Rhythm disturbances that develop after pediatric surgery for heart disease significantly increase mortality and morbidity risk. The aim of this study was to determine incidence rates of different arrhythmias and identify risk factors for these disturbances in this patient group. The study involved 580 children in the p... |
6,893 | Modulation of the sinus rate during ventricular fibrillation. | During supraventricular and ventricular tachycardia, the arterial baroreflex predominates with minimal contribution from the cardiopulmonary reflex. To our knowledge, the role of the arterial baroreflex gain (BRG) during and immediately following termination of ventricular fibrillation (VF) has not been characterized.<... |
6,894 | Gene Variant of the Bradykinin B2 Receptor Influences Pulmonary Arterial Pressures in Heart Failure Patients. | BACKGROUND: Pulmonary arterial pressure (PAP) varies considerably in heart failure (HF) despite similar degrees of left ventricular (LV) dysfunction. Bradykinin alters vascular tone and common variations in the kinin B2 receptor (BDKRB2) gene exists. We hypothesized that genetic variation in this receptor would influen... |
6,895 | Remote implantable cardioverter defibrillator monitoring in a Brugada syndrome population. | The diagnosis of Brugada syndrome (BS) is typically made in a young and otherwise healthy population. In patients with a high risk of sudden cardiac death (SCD), the only currently recommended therapy is an implantable cardioverter defibrillator (ICD), but these are not without complications. We investigated whether re... |
6,896 | Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias. | The synchronization of coupled oscillators plays an important role in many biological systems, including the heart. In heart diseases, cardiac myocytes can exhibit abnormal electrical oscillations, such as early afterdepolarizations (EADs), which are associated with lethal arrhythmias. A key unanswered question is how ... |
6,897 | [Long QT syndrome: an underestimated cause of sudden infant death]. | Congenital long QT syndrome (LQTS) is an inherited arrhythmia that can be sporadic or familial. It predisposes to sudden cardiac death by ventricular fibrillation, which can occur at any age, particularly in neonates. Recent postmortem molecular screening surveys have shown that 10 to 12% of sudden infant death syndrom... |
6,898 | Acute ischemic heart disease alters ventricular fibrillation waveform characteristics in out-of hospital cardiac arrest. | Although ventricular fibrillation waveform characteristics (VFWC) correlate with coronary perfusion pressure and may predict defibrillation outcome, recent animal data indicate that these waveform characteristics are altered in both acute myocardial infarction (AMI) and chronic coronary heart disease (CHD). We wanted t... |
6,899 | Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy. | Our purpose was to evaluate the efficacy of antiarrhythmic drugs (AADs) in recurrent ventricular fibrillation (VF) associated with inferolateral early repolarization pattern on the electrocardiogram.</AbstractText>Although an implantable cardioverter-defibrillator is the treatment of choice, additional AADs may be nece... |
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