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8,600
Left atrial remodelling in mitral regurgitation--methodologic approach, physiological determinants, and outcome implications: a prospective quantitative Doppler-echocardiographic and electron beam-computed tomographic study.
To define accurate and normal range of echocardiographic left atrial (LA) volume measurement and to assess the prevalence, determinants, and outcome implications of LA enlargement in mitral regurgitation (MR).</AbstractText>We prospectively compared LA volume obtained simultaneously by electron beam-computed tomography...
8,601
[Ventricular fibrillation after administration of succinylcholine].<Pagination><StartPage>209</StartPage><EndPage>210</EndPage><MedlinePgn>209-10</MedlinePgn></Pagination><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garc&#xed;a</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="...
Possibility of prevention of atrial fibrillation in patients with permanent pacemakers was analyzed taking into account induction mechanisms. Patients with bradicardiac and ectopic mechanisms of atrial fibrillation induction seem to be optimal candidates for pacemaker therapy. Right ventricular pacing was an independen...
8,602
Usefulness of percutaneous left ventricular assist device as a bridge to recovery from myocarditis.
The TandemHeart percutaneous left ventricular assist device is a left atrial-to-femoral artery bypass system that can be implanted percutaneously within 30 minutes and provides active circulatory support. The TandemHeart has been used mainly for temporary hemodynamic assistance during high-risk coronary interventions a...
8,603
Clinical and echocardiographic markers of mortality risk in patients with atrial fibrillation.
Atrial fibrillation (AF) is independently associated with increases in cardiovascular and all-cause mortality. Although cardiovascular co-morbidities predict stroke risk in AF, their relation with mortality has not been well described. To identify clinical and echocardiographic markers of mortality in patients with AF,...
8,604
Body mass index is an independent determinant of left atrial size.
Obesity is a risk factor for atrial fibrillation (AF) but the mechanisms underlying this association are unclear. We aimed to assess whether body mass index (BMI) is an independent determinant of left atrial size, in subjects in sinus rhythm.</AbstractText>Subjects were consecutive ambulatory patients aged &gt;/=18 yea...
8,605
Biliopancreatic diversion reduces QT interval and dispersion in severely obese patients.
The objectives were to evaluate QT interval (QTc) and QT-interval dispersion (QTd) in severely obese individuals and to determine the effects of biliopancreatic diversion (BPD) and weight loss after BPD on ventricular repolarization parameters.</AbstractText>People with severe obesity (SO) have a 50% to 100% increased ...
8,606
Transmural and endocardial Purkinje activation in pigs before local myocardial activation after defibrillation shocks.
Earliest recorded postshock myocardial activations in pigs originate in the subepicardium of the apex and lateral free wall of the left ventricle (LV) 30-90 ms after the shock.</AbstractText>The purpose of this study was to determine whether the Purkinje system is a candidate for the source of postshock activations by ...
8,607
Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation.
Some patients with Brugada syndrome experience an electrical storm of ventricular fibrillation (VF).</AbstractText>The purpose of this study was to investigate the clinical, laboratory, electrocardiographic, and electrophysiologic characteristics, acute and subsequent chronic treatment, and follow-up data of patients w...
8,608
Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation.
We investigated implementation and efficacy of mild therapeutic hypothermia in the treatment of out-of-hospital cardiac arrest due to ventricular fibrillation.</AbstractText>Two periods were compared, an historical one (36 patients) between 2000 and 2002 where therapeutic hypothermia was never used, and a recent period...
8,609
Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts.
Ventricular fibrillation (VF) studies show that ECG-dominant frequency (DF) decreases as ischemia develops. This study investigates the contribution of the principle ischemic metabolic components to this decline.</AbstractText>Rabbit hearts were Langendorff-perfused at 40 mL/min with Tyrode's solution and loaded with R...
8,610
Postprandial augmentation of bradycardia-dependent ST elevation in patients with Brugada syndrome.
In patients with Brugada syndrome, the circadian variation of ST elevation could be modulated by the autonomic nervous activity and RR interval. Recently, glucose-induced insulin secretion was also reported to contribute to fluctuation of ST elevation. Therefore, we assessed the effects of taking meals on the ST-RR rel...
8,611
Rare survival in a patient with severe complications of acute myocardial infarction: a case report.
A 50-year-old man presented with acute myocardial infarction. Coronary angiography showed the left anterior descending artery (segment 6) was totally occluded. Direct percutaneous transluminal coronary angioplasty was performed, but a distal embolism occurred by the procedure. Consequently, he suffered cardiogenic shoc...
8,612
The quality of chest compressions during cardiopulmonary resuscitation overrides importance of timing of defibrillation.
We address the quality of chest compressions and the impact on initial defibrillation or initial chest compressions after sudden death.</AbstractText>Ventricular fibrillation was induced by occlusion of the left anterior descending coronary artery in 24 domestic pigs with a mean (+/- SD) weight of 40 +/- 2 kg. Cardiac ...
8,613
Parameters characterizing implantable defibrillator output: a proposal.
Recently, a discussion was carried out in Heart Rhythm on the specifications that could characterize implantable defibrillators. It is the intention of this paper to participate in this discussion on defibrillation characteristics and to give recommendations on how this problem could be solved. Theoretical consideratio...
8,614
Exacerbation of acidosis during ischemia and reperfusion arrhythmia in hearts from type 2 Diabetic Otsuka Long-Evans Tokushima Fatty rats.
Sensitivity to ischemia and its underlying mechanisms in type 2 diabetic hearts are still largely unknown. Especially, correlation between reperfusion induced ventricular arrhythmia and changes in intracellular pH has not been elucidated.</AbstractText>Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 16 and 32 we...
8,615
Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline.
Although delayed hospital cooling has been demonstrated to improve outcome after cardiac arrest, in-field cooling started immediately after the return of spontaneous circulation may be more beneficial. The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling.</Ab...
8,616
Angiotensin converting enzyme inhibitor and angiotensin receptor blockade use in relation to outcomes in anticoagulated patients with atrial fibrillation.
The renin-angiotensin-aldosterone-system (RAAS) plays an important role in atrial fibrillation (AF). Evidence shows that blocking the RAAS with angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) has a definite role in preventing new onset AF and in maintaining sinus rhythm in recu...
8,617
Occurrence of "J waves" in 12-lead ECG as a marker of acute ischemia and their cellular basis.
The "J wave" (also referred to as "the Osborn wave,""the J deflection," or "the camel's hump") is a distinctive deflection occurring at the QRS-ST junction. In 1953, Dr. John Osborn described the "J wave" as an "injury current" resulting in ventricular fibrillation during experimental hypothermia. Although "J Wave" is ...
8,618
Single chamber atrial pacing: a realistic option in sinus node disease: a long-term follow-up study of 213 patients.
Despite several decades of experience with atrial pacing, many centers do not apply this mode to any greater extent, mainly because of concerns for the development of future atrioventricular (AV) block or atrial fibrillation. Recent studies have emphasized possible negative effects of right ventricular stimulation, eve...
8,619
The pre-hospital phase of acute myocardial infarction: a national audit is needed in New Zealand.
The outcome of acute myocardial infarction is usually settled before the patient reaches hospital, because ventricular fibrillation, when it occurs, is most common soon after the onset of symptoms. Ventricular fibrillation can be treated as effectively by ambulance personnel as in hospital, and many more deaths can be ...
8,620
Role of p38 mitogen-activated protein kinase on cardiac dysfunction after hemorrhagic shock in rats.
Cardiac dysfunction is a well-known complication of hemorrhagic shock as a consequence of local inflammatory response. Several studies have indicated that p38 mitogen-activated protein kinase (MAPK) is a key mediator in organ dysfunction that is associated with the inflammatory state through the activation of proinflam...
8,621
Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart.
Changes in ventricular fibrillation (VF) organization occurring after the onset of global ischemia are relevant to defibrillation and survival but remain poorly understood. We hypothesized that ischemia-specific dynamic instability of the action potential (AP) causes a loss of spatiotemporal periodicity of propagation ...
8,622
Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability.
Previous studies have demonstrated that the slope of the function relating the action potential duration (APD) and the diastolic interval, known as the APD restitution curve, plays an important role in the initiation and maintenance of ventricular fibrillation. Since the APD restitution slope critically depends on the ...
8,623
Atrial fibrillation reduces the atrial impedance amplitude during cardiac cycle: a novel detection algorithm to improve recognition of atrial fibrillation in pacemaker patients.
In carriers of dual chamber pacemakers and implantable cardioverter-defibrillators (ICD), detection of atrial fibrillation (AF) is crucial for adequate mode switch function and to avoid inappropriate shock delivery. Detection algorithms rely on the atrial rate and on the relationship of atrial to ventricular intracardi...
8,624
Effects of pericardial lidocaine on hemodynamic parameters and responses in dogs anesthetized with midazolam and fentanyl.
Tachycardia during anesthesia should be avoided, especially during off-pump coronary artery bypass graft surgery. Decreasing heart rate without reducing cardiac contractility is an ideal goal. To achieve this, the authors attempted to block the cardiac nerves by pericardial administration of local anesthetic.</Abstract...
8,625
Atrial fibrillation in the Wolff-Parkinson-White syndrome: ECG recognition and treatment in the ED.
Estimated to occur in 0.1% to 0.3% of the population, Wolff-Parkinson-White syndrome (WPW) is a condition where atrial impulses bypass the atrioventricular node and activate the ventricular myocardium directly via an accessory pathway. Clinical clues to the diagnosis include a young patient with previous episodes of pa...
8,626
Thrombolytic therapy vs primary percutaneous intervention after ventricular fibrillation cardiac arrest due to acute ST-segment elevation myocardial infarction and its effect on outcome.
The aim of this study was to evaluate the effect of thrombolytic therapy on neurologic outcome and mortality in patients after cardiac arrest due to acute ST-elevation myocardial infarction and to compare this with those in patients treated with primary percutaneous coronary intervention (PCI). We retrospectively exami...
8,627
Epinephrine, but not vasopressin, improves survival rates in an adult rabbit model of asphyxia cardiac arrest.
Although vasopressin has been reported to be more effective than epinephrine for cardiopulmonary resuscitation in ventricular fibrillation animal models, its efficacy in asphyxia model remains controversy. The purpose of this study was to investigate the effectiveness of vasopressin vs epinephrine on restoration of spo...
8,628
Can untrained laypersons use a defibrillator with dispatcher assistance?
Automated external defibrillators (AEDs) provide an opportunity to improve survival in out-of-hospital cardiac arrest by enabling laypersons not trained in rhythm recognition to deliver lifesaving therapy. This study was performed to examine whether untrained laypersons could safely and effectively use these AEDs with ...
8,629
Organization of ventricular fibrillation in the human heart.
Sudden cardiac death is a major cause of death in the industrialized world, claiming approximately 300,000 victims annually in the United States alone. In most cases, sudden cardiac death is caused by ventricular fibrillation (VF). Experimental studies in large animal hearts have shown that the uncoordinated contractio...
8,630
The obstacles to maximising the impact of public access defibrillation: an assessment of the dispatch mechanism for out-of-hospital cardiac arrest.
To determine the diagnostic accuracy of advanced medical priority dispatch system (AMPDS) software used to dispatch public access defibrillation first responders to out-of-hospital cardiac arrests (OHCA).</AbstractText>All true OHCA events in North and West Belfast in 2004 were prospectively collated. This was achieved...
8,631
Ventricular arrhythmia discriminator programming and the impact on the incidence of inappropriate therapy in patients with implantable cardiac defibrillators.
The incidence of inappropriate therapy from implantable cardioverter defibrillators (ICDs) has been reduced by programming ventricular arrhythmia discriminators (VAD) on at the time of implant.</AbstractText>To determine which VAD is most effective in preventing inappropriate therapy.</AbstractText>Dual chamber ICD (n=...
8,632
Approach to the asymptomatic patients with Brugada syndrome.
Brugada syndrome is an arrhythmogenic disease characterized by an ECG pattern of coved-type ST segment elevation in the right precordial leads and an increased risk of sudden cardiac death (SCD) as a result of polymorphic ventricular tachyarrhythmia or ventricular fibrillation (VF). Data from large patient studies and ...
8,633
Improved survival associated with prophylactic implantable defibrillators in elderly patients with prior myocardial infarction and depressed ventricular function: a MADIT-II substudy.
We aim to evaluate the mortality benefit from defibrillator therapy in eligible elderly patients. Effective primary prevention of sudden cardiac death with implantable cardioverter defibrillators is well demonstrated in patients with coronary disease and depressed ventricular function.</AbstractText>Among 1,232 patient...
8,634
Fatal Loeffler's endocarditis due to hypereosinophilic syndrome.
Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. We report the case of a 54-year-old woman with a remote history of seizure disorder who presented with early signs of right-sided heart failure. Laboratory studies showed significant eosinophilia (8 x 10(9) l(-1)). Computed ...
8,635
Isolated noncompaction of the left ventricular myocardium -- a review of the literature two decades after the initial case description.
Isolated noncompaction of the left ventricular myocardium (INVM), first described in 1984, is an unclassified cardiomyopathy and is assumed to occur as an arrest of the compaction process during the normal development of the heart. Between weeks 5 to 8 of human fetal development, the ventricular myocardium undergoes gr...
8,636
Post automatic implantable cardioverter defibrillator implant therapies: drugs and ablative techniques.
The aim of this article is to report the evidences about the use of drugs and ablation after implantation of a cardioverter defibrillator. Drugs can be utilized to prevent appropriate and inappropriate shocks, can influence positively or negatively defibrillation threshold, can be useful for the treatment of electrical...
8,637
Inefficiency of renin-angiotensin inhibitors in preventing atrial fibrillation in patients with a normal heart.
Recent scientific evidence has emphasized the possible role of inhibitors of the renin-angiotensin system in preventing arrhythmic relapses in patients with paroxysmal or persistent atrial fibrillation and co-existing left ventricular hypertrophy or left ventricular dysfunction.</AbstractText>In order to verify the eff...
8,638
Incidence of shock and quality of life in young patients with implantable cardioverter-defibrillator.
To analyze the incidence and causes of ICD therapies in children and young adults and verify their impact on the quality of life (QoL).</AbstractText>From March/1977 to February/2006, 29 patients (15.7+/-5.4 years old) were submitted to ICD implants. Aborted cardiac arrest (41.5%), sustained ventricular tachycardia (27...
8,639
The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement.
The incidence of patient-prosthesis mismatch after mitral valve replacement and its effect on late outcomes have remained unclear. This study was conducted to determine the impact of patient-prosthesis mismatch on recurrent congestive heart failure, postoperative pulmonary hypertension, and late survival after mitral v...
8,640
Characteristics of congestive heart failure accompanied by atrial fibrillation with special reference to tachycardia-induced cardiomyopathy.
Sustained tachycardia causes left ventricular (LV) systolic dysfunction leading to heart failure (HF), which is widely known as "tachycardia-induced cardiomyopathy (TIC)", but its prevalence and prognosis in Japanese remain unclear.</AbstractText>Of 213 consecutive patients with HF associated with atrial fibrillation (...
8,641
Inappropriate interventions during the long-term follow-up of patients with an implantable defibrillator.
In patients with an implantable defibrillator (ICD), inappropriate ICD interventions alter the quality of life, may cause hospitalisations and limit cost-effectiveness. The aim of the study was to determine the incidence and causes of inappropriate ICD interventions, and to identify patients at risk.</AbstractText>For ...
8,642
[Transapical approach for aortic stented valve implantation: experimental results].
Percutaneous aortic valve replacement has been performed in humans mainly for non-surgical candidates. We evaluated on animals a transapical approach to deliver an aortic stented valve without cardiopulmonary bypass.</AbstractText>A tubular pericardial valve fixed within a cobalt-nickel stent (Medtronic, Inc.) was impl...
8,643
[Long QT syndrome induced by cordaron and quinidine].
The article presents an observation of a 63-year-old female patient suffering from arterial hypertension, coronary artery disease complicated by a persistent form of atrial fibrillation during 1.5 months, and hereditary Minkowski-Chauffard hemolytic anemia. Treatment with cordaron proved to be ineffective, while oral a...
8,644
Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment.
Hypertrophic cardiomyopathy (HCM) is an inherited disease with marked phenotypic variability that includes the extent of hypertrophy, the presence and severity of symptoms, and the natural history of the disease. Symptoms of impaired consciousness (syncope and pre-syncope) occur in approximately 15-25% of patients with...
8,645
Atrial fibrillation and congestive heart failure: a two-way street.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical cardiology, particularly in patients with heart failure. Its prevalence increases with the degree of left ventricular dysfunction and severity of heart failure symptoms. The development of AF in the setting of heart failure...
8,646
Tako-tsubo cardiomyopathy complicating left atrial radiofrequency ablation.
Two female patients undergoing left atrial radiofrequency catheter ablation developed Tako-tsubo cardiomyopathy. This reversible form of left ventricular dysfunction is known to occur under conditions associated with marked sympathetic nervous activation. Radiofrequency catheter ablation in the left atrium can damage a...
8,647
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.
Short QT syndrome (SQTS) is a newly described ion channelopathy, characterized by a short QT interval resulting from an accelerated cardiac repolarization, associated with syncope, atrial fibrillation, and sudden cardiac death due to ventricular fibrillation. As therapeutic options in SQTS are still controversial, we e...
8,648
Anionic currents in hypoxia-mediated cardiac toxicity: a computer study.
Hypoxia-caused modulation of cardiac electrophysiology was modeled by computer simulation. Emphasis was on the effect of activation of anionic channels on the electrical state of the tissue. The model includes implicitly the effect of the presence of reactive oxygen species (ROS) and nitrogen oxide (NO) on myocyte memb...
8,649
[Successful use of an AED following anterior myocardial infarction].
A participant of the annual Hamburg marathon collapses on the finish line. Medics at the scene find a conscious patient and prepare transport to the finish area medical center. During transport the patient becomes unconscious and pulseless. The medics immediately perform basic life support and cardiopulmonary resuscita...
8,650
Determinants of plasma levels of brain natriuretic peptide after acute ischemic stroke or TIA.
Plasma levels of brain natriuretic peptide (BNP) are frequently elevated after an acute stroke and have been shown to be an independent predictor of mortality. However, the relationships between stroke and BNP concentrations have not yet been systematically investigated. Plasma BNP assay and echocardiography were perfo...
8,651
Prediction of atrial fibrillation in patients with cardiac dysfunctions: P wave signal-averaged ECG and chemoreflexsensitivity in atrial fibrillation.
Atrial fibrillation (AF) is a common arrhythmia in advanced heart failure. The occurrence of AF increases the risk of death and hospitalization for patients with heart failure. The results of different studies indicated that patients with paroxysmal AF have a longer filtered P wave duration (FPD), a lower root mean squ...
8,652
Catheter ablation of premature ventricular contractions originating from the His bundle region.
We describe a 35-year-old man with idiopathic frequent premature ventricular contractions (PVCs) originating from the His-bundle region, where a low frequency ventricular potential was recorded in the bipolar recording and QR pattern in the unipolar recording. Electro-anatomical mapping revealed a confined low voltage ...
8,653
Ventricular rate smoothing for atrial fibrillation: a quantitative comparison study.
To quantitatively compare the ventricular rate-smoothing (VRS) effects of different ventricular pacing (VP) protocols for atrial fibrillation (AF).</AbstractText>Using a recently developed open-source model that can simulate the ventricular response in AF and VP, the performance of fixed-rate pacing and four previously...
8,654
Prevalence and prognostic impact of comorbidities in heart failure patients with implantable cardioverter defibrillator.
This study assessed the prevalence and the prognostic impact of comorbidities in heart failure patients with implantatable cardioverter-defibrillator (ICD).</AbstractText>We prospectively enrolled 146 patients with chronic heart failure, an ICD, and systolic dysfunction (mean ejection fraction 29 +/- 10%). Cardiac deat...
8,655
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
The occurrence of ventricular fibrillation (VF) is dependent on the deterioration of channelopathy in the myocardium. It is interesting to investigate molecular changes in relation to abrupt appearance of VF on reperfusion. We aimed to study whether changes in the expression of FKBP12.6 and SERCA2a and the endothelin (...
8,656
[Evaluation of atrial function by echocardiography].
In cardiology, ventricular function has extensively been studied, whereas atrial function received less attention. For such a reason atrial function is less known. The aim of this review was to summarize the role of atrial function and to explain how echocardiography and new echocardiographic-derived techniques may be ...
8,657
[Permanent atrial fibrillation and heart failure: radiofrequency ablation of atrioventricular junction and cardiac resynchronization therapy: review of the literature and of the new techniques for echocardiographic assessment].
Radiofrequency ablation of atrioventricular junction plus pacing therapy ("ablate and pace") is an effective non-pharmacological therapy in patients with medically refractory permanent atrial fibrillation and heart failure. However, the chronic right ventricular pacing may result in regional wall motion abnormalities a...
8,658
A PET study of regional cerebral blood flow after experimental cardiopulmonary resuscitation.
Cerebral blood flow (CBF) during cardiopulmonary resuscitation and after restoration of spontaneous circulation (ROSC) from cardiac arrest has previously been measured with the microspheres and laser Doppler techniques. We used positron emission tomography (PET) with [15O]--water to map the haemodynamic changes after R...
8,659
Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery.
Atrial fibrillation (AF) occurs frequently after coronary artery bypass grafting (CABG) and often results in prolonged postsurgical hospital stays and increased mortality and morbidity. Beta blockers are known to prevent postoperative AF. In this prospective study, we investigated the efficacy of carvedilol compared wi...
8,660
Broad complex atrial fibrillation.
The management of broad complex atrial fibrillation is complex and may be a source of morbidity and mortality if not correctly recognized and treated appropriately. We present a case series of 3 patients who were managed in our emergency department after complaints of palpitations. They presented with varying forms of ...
8,661
External cardiac defibrillation during wet-surface cooling in pigs.
During surface cooling with ice-cold water, safety and effectiveness of transthoracic defibrillation was assessed.</AbstractText>In a pig ventricular fibrillation cardiac arrest model, once (n = 6), defibrillation was done first in a dry and then in a wet condition using the ThermoSuit System (Life Recovery Systems, HD...
8,662
Prevalence and predictors of arrhythmia in end stage renal disease patients on hemodialysis.
Sudden death is common in end-stage renal disease (ESRD). Cardiac arrhythmia is observed frequently in patients with ESRD and is thought to be responsible for this high rate of sudden death. This study investigated the prevalence and the predictors of arrhythmia in patients on maintenance dialysis.</AbstractText>Ninety...
8,663
Idiopathic ventricular fibrillation.
Idiopathic ventricular fibrillation (IVF) is responsible for a sizable part of sudden cardiac death (SCD). Furthermore, it has a high recurrence rate. Recent publications have shown that IVF is often caused by premature ventricular contractions (PVCs) arising from the right ventricular outflow tract (RVOT) or the Purki...
8,664
[Short QT syndrome].
Short QT syndrome is a new genetic disorder associated with familial atrial fibrillation and/or sudden death or syncope. To date, different mutations in genes encoding for cardiac ion channels (KCNH2, KCNQ1, and KCNJ2) have been identified to cause the short QT syndrome. The mutations lead to a gain of function of the ...
8,665
Adherence to resuscitation guidelines during prehospital care of cardiac arrest patients.
The impact of prehospital care after the return of spontaneous circulation in out-of-hospital cardiac arrest patients is not known. This study describes adherence to the resuscitation guidelines, factors associated with poor adherence and possible impact of prehospital postresuscitation care on the outcome of out-of-ho...
8,666
Simultaneous onset of hemorrhagic and ischemic strokes.
Primary brain hemorrhage and infarction only very rarely occur simultaneously. We report a patient with the simultaneous onset of hemorrhagic and ischemic strokes who had uncontrolled hypertension and atrial fibrillation. Neuroradiologic investigations revealed a large right thalamic hematoma with ventricular extension...
8,667
Trauma associated with cardiac dysrhythmias: results from a large matched case-control study.
Various cardiac dysrhythmias such as supraventricular and ventricular premature beats, supraventricular and ventricular paroxysmal tachycardia, atrial and ventricular fibrillation and atrial flutter have been reported in case series, as complications of blunt cardiac and thoracic trauma. The objective of this research ...
8,668
A neurobiological basis for ELF guidelines.
It is well understood that electric currents applied directly to the body can stimulate peripheral nerve and muscle tissue; such effects can be fatal if breathing is inhibited or ventricular fibrillation is induced. Exposure to extremely low frequency electric and magnetic fields will also induce electric fields and cu...
8,669
Effects of rotigaptide, a gap junction modifier, on defibrillation energy and resuscitation from cardiac arrest in rabbits.
The gap junction modifier Rotigaptide (ZP123), which promotes cellular coupling, was hypothesized to decrease defibrillation thresholds during prolonged ventricular fibrillation (VF). Thirty-two New Zealand white rabbits were randomized to receive saline (control, n = 16) or Rotigaptide (n = 16). Following 4 min of unt...
8,670
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function.
Dofetilide is currently recommended as second-tier therapy to maintain sinus rhythm in patients with paroxysmal atrial fibrillation (PAF) and normal left ventricular function, yet limited data support this recommendation. We examined the safety and efficacy of dofetilide in this setting through a retrospective chart re...
8,671
Electrical cardioversion for persistent atrial fibrillation or atrial flutter in clinical practice: predictors of long-term outcome.
Despite the results of Atrial Fibrillation Follow-up Investigation of Rhythm Management and Rate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation trials, which favour a general shift in atrial fibrillation (AF) therapeutic approach towards control of ventricular rate, a strategy based on resto...
8,672
Catheter ablation of cardiac arrhythmias guided by electroanatomic imaging (CARTO): a single-center experience.
Catheter ablation is assuming a larger role in the management of patients with cardiac arrhythmias. Conventional fluoroscopic catheter mapping has limited spatial resolution and involves prolonged fluoroscopy. The non-fluoroscopic electroanatomic mapping technique (CARTO) has been developed to overcome these drawbacks....
8,673
Therapeutic hypothermia for comatose survivors after cardiac arrest.
Unconscious adults with spontaneous circulation after out-of-hospital cardiac arrest should be cooled to 32-34 degrees C (ILCOR recommendations, 2003) when the initial rhythm is ventricular fibrillation.</AbstractText>To assess the technique, safety and efficacy of mild induced hypothermia in patients after OHCA due to...
8,674
Late mortality and determinants in patients with heart failure and preserved systolic left ventricular function: the Israel Nationwide Heart Failure Survey.
Heart failure with preserved systolic left ventricular function is a major cause of cardiac disability.</AbstractText>To examine the prevalence, characteristics and late clinical outcome of patients hospitalized with HF-PSF on a nationwide basis in Israel.</AbstractText>The Israel nationwide HF survey examined prospect...
8,675
Left ventricular diastolic dysfunction in essential hypertension.
T Diastolic dysfunction is very frequent and is actually sign of manifest heart weakness. Over 40% of patients with heart weakness have isolated left ventricular diastolic dysfunction (LVDD). New diagnostics methods as Doppler Echocardiography with close monitoring enables precise and early LVDD diagnose. In all diasto...
8,676
Complications of hypertension and the role of angiotensin receptor blockers in hypertension trials.
Hypertension is a high-prevalence disease that may affect several organs. In recent years, data have accumulated indicating that angiotensin II receptor blockers (ARBs) may have a supplementary effect beyond lowering blood pressure. The aim of this review is to evaluate the impact of ARBs on the most important complica...
8,677
The automated external defibrillator.
Sudden death claims 250,000 lives annually in the U.S. The vast majority of such events are due to ventricular fibrillation and ventricular tachycardia. Even though these arrhythmias can be converted if treated promptly, less than 5% of victims of out-of-hospital cardiac arrest survive to hospitalization. This poor sur...
8,678
NaviStar ThermoCool catheter for ventricular tachycardia.
Despite the relatively short history of catheter ablation, it has clearly demonstrated high efficacy and safety in treating a wide spectrum of cardiac arrhythmias. An important contributor to this success has been the rapid incorporation of evolving technologies that have changed the practice of electrophysiology remar...
8,679
Acute heart failure syndromes: clinical scenarios and pathophysiologic targets for therapy.
Acute heart failure syndromes (AHFS) represent the most common discharge diagnosis in patients over age 65 years, with an exceptionally high mortality and readmission rates at 60-90 days. Recent surveys and registries have generated important information concerning the clinical characteristics of patients with AHFS and...
8,680
[QTc-prolonging drugs and the risk of sudden death].
Various drugs can be associated with QT prolongation. A prolonged QT interval leads to an increased risk for the development of ventricular tachyarrhythmias, particularly polymorphic ventricular tachycardia (torsades de pointes). Polymorphic arrhythmia may rapidly develop into ventricular fibrillation and cause sudden ...
8,681
Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).
In patients with heart failure, rates of clinically apparent stroke range from 1.3% to 3.5% per year. Little is known about the incidence and risk factors in the absence of atrial fibrillation. In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), 2521 patients with moderate heart failure were randomized to re...
8,682
Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data.
Brugada syndrome (BS) is an ion channelopathy with the risk of sudden cardiac death. The role of programmed ventricular stimulation (PVS) in risk stratification has been controversially discussed. Therefore, we performed a meta-analysis on the prognostic role of PVS in BS.</AbstractText>A Medline search until July 2006...
8,683
Cardiology at Westmead Hospital from 1990 to 2007.
Professor John Uther was the Director of Cardiology at Westmead Hospital from 1979 to 1990. Professor David Ross and Dr Pramesh Kovoor followed in this capacity subsequently. Networking between Westmead and metropolitan hospitals was established by conjoint appointment of cardiologists across the facilities. Westmead h...
8,684
Demographic, clinical and echocardiographic determinants of B-type natriuretic peptide plasma concentration. A population-based study.
The aim of this study was to identify determinants of plasma B-type natriuretic peptide (BNP) levels at the population level.</AbstractText>In a cross-sectional study, the authors evaluated 559 community subjects aged &gt; or = 45 years. The association between plasma BNP concentration and the hypothesized determinants...
8,685
Conduction abnormalities and anaesthesia.
Accurate identification of patients at risk for ventricular arrhythmias is critical to prevent sudden cardiac death. The perioperative period is usually regarded as one of risk for potential triggering conditions. This review focuses on the anaesthesiologic risk of inherited arrhythmias whose aetiology is a mutation in...
8,686
Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea.
Obstructive sleep apnea (OSA) and obesity have been linked to systolic and diastolic dysfunction of the left ventricle. Right ventricular function is poorly understood in the 2 clinical conditions. Data from this study show that otherwise healthy obese patients with OSA had increased an left atrial volume index compare...
8,687
Comparison of usefulness of cardiac resynchronization therapy in patients with atrial fibrillation and heart failure versus patients with sinus rhythm and heart failure.
The prevalence of atrial fibrillation (AF) in patients with heart failure is high, but data about the effects of cardiac resynchronization therapy (CRT) in patients with chronic AF are scarce. In this prospective observational study of 263 consecutive patients, CRT was performed in 96 patients (37%) with chronic AF and...
8,688
The role of pacing in rhythm control and management of atrial fibrillation.
Atrial fibrillation is the most common sustained cardiac arrhythmia and is increasing in prevalence with an ageing population. As the arrhythmia is often asymptomatic the true prevalence is likely even higher. Largely because of stroke this arrhythmia places a huge financial burden on the health economy. Despite this, ...
8,689
Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia.
This study tested whether bepridil, a multichannel blocker, would reverse electrical remodeling induced by persistent atrial tachycardia.</AbstractText>Fourteen dogs were subjected to rapid atrial pacing at 400 bpm for 6 weeks after atrioventricular block was created to control the ventricular rate. During the study pe...
8,690
Dronedarone: drondarone, SR 33589, SR 33589B.
Dronedarone, a potassium channel antagonist, is chemically related to amio-darone. It is being developed by sanofi-aventis as a class III antiarrhythmic agent for the treatment of atrial fibrillation and atrial flutter in the US and Europe. Dronedarone has a favourable benefit/risk ratio, with the absence of any proarr...
8,691
Study for relevance of the acute myocardial ischemia to arrhythmia by the optical mapping method.
Ventricular arrhythmias are commonly observed in patients with acute coronary occlusion and ischemia. The purpose of the present study is to determine ischemic electrophysiological effects and their role in ischemia-induced arrhythmia. Optical mapping of the membrane potential with voltage-sensitive dyes was used in th...
8,692
Inductionless or limited shock testing is possible in most patients with implantable cardioverter- defibrillators/cardiac resynchronization therapy defibrillators: results of the multicenter ASSURE Study (Arrhythmia Single Shock Defibrillation Threshold Testing Versus Upper Limit of Vulnerability: Risk Reduction Evalua...
Implantable cardioverter-defibrillators and cardiac resynchronization therapy defibrillators have relied on multiple ventricular fibrillation (VF) induction/defibrillation tests at implantation to ensure that the device can reliably sense, detect, and convert VF. The ASSURE Study (Arrhythmia Single Shock Defibrillation...
8,693
Annual rate of transvenous defibrillation lead defects in implantable cardioverter-defibrillators over a period of &gt;10 years.
The number of patients with longer follow-up after implantation of an implantable cardioverter-defibrillator is increasing continuously. Defibrillation lead failure is a typical long-term complication. Therefore, the long-term reliability of implantable cardioverter-defibrillator leads has become an increasing concern....
8,694
The impedance threshold valve for adult cardiopulmonary resuscitation: a review of the literature.
Heart-lung interaction is an important parameter in the understanding of blood-flow induction during cardiopulmonary resuscitation. The impedance threshold valve is a device which has been created to increase venous return by occluding the airway during the decompression phase of cardiopulmonary resuscitation. This rev...
8,695
Monitoring the quality of cardiopulmonary resuscitation.
Numerous recent reports have described limitations in the quality of cardiopulmonary resuscitation. Thus, there has been increasing interest in the techniques available to monitor quality. This review focuses on the major publications since the review published by the International Liaison Committee on Resuscitation in...
8,696
Attitudes of Ohio dentists and dental hygienists on the use of automated external defibrillators.
The American Heart Association reports that approximately 220,000 people die each year of sudden cardiac arrest. In ventricular fibrillation (VF), the most common abnormal heart rhythm that causes cardiac arrest, the heart's electrical impulses suddenly become chaotic, often without warning. Death will follow within mi...
8,697
Rhythm discrimination during uninterrupted CPR using motion artifact reduction system.
Due to motion artifact in the ECG caused by chest compressions automatic external defibrillators (AEDs) have difficulty recognizing ventricular fibrillation (VF) during cardiopulmonary resuscitation (CPR). Frequent interruption of CPR is required for artifact-free ECG interpretation, but these interruptions reduce the ...
8,698
Supraventricular arrhythmias in noncompaction of left ventricle: is this a frequent complication?
Isolated left ventricular noncompaction is the result of incomplete myocardial morphogenesis, leading to persistence of the embryonic myocardium. The condition is recognised by an excessively prominent trabecular meshwork and deep intertrabecular recesses of the left ventricle. Whether these intertrabecular recesses ar...
8,699
Ventricular fibrillation: how do we put the genie back in the bottle?
I am deeply grateful and honored to receive the 2006 Distinguished Scientist Award from the Heart Rhythm Society. Many outstanding individuals have received this award since it was established in 1982, and it is humbling to realize that my small feet are walking in the footsteps of these giants. I would be remiss if I ...