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9,500 | Peripheral and cerebral atherothrombosis and cardiovascular events in different vascular territories: insights from the Framingham Study. | Major risk factors for clinical atherosclerosis include dyslipidemia, hypertension, glucose intolerance, adiposity, cigarette smoking, hemostatic factors, inflammatory markers, and sedentary lifestyle. Sets of some of these and evidence of vascular damage such as left ventricular hypertrophy and atrial fibrillation are... |
9,501 | Effect of oligomer procyanidins on reperfusion arrhythmias and lactate dehydrogenase release in the isolated rat heart. | The antiarrhythmic effect of an oral 3-week-pretreatment with oligomer procyanidins derived from Vitis vinifera was investigated on the isolated perfused heart after global no-flow ischemia (procyanidin-treated group: n = 9, control group: n = 13). Hearts were perfused with a modified Krebs-Henseleit solution in which ... |
9,502 | Natural history and predictors of outcome in patients with concomitant functional mitral regurgitation at the time of aortic valve replacement. | Concomitant functional mitral regurgitation (FMR) in patients undergoing aortic valve replacement (AVR) is frequently not corrected because it may improve after AVR; however, data supporting this assumption are sparse. We ascertained the impact of clinical and echocardiographic parameters on the outcome of patients wit... |
9,503 | Multislice computed tomography accurately quantifies left atrial size and function after the MAZE procedure. | Although the MAZE procedure allows for the recovery of sinus rhythm and left atrial (LA) mechanical function in the great majority of patients with chronic atrial fibrillation (AF), the effects of MAZE on the precise LA geometry and wall motion remain to be elucidated. We hypothesized that LA size and mechanical functi... |
9,504 | Mitral valve repair versus revascularization alone in the treatment of ischemic mitral regurgitation. | For patients with ischemic mitral regurgitation (MR), it is not clear whether adjunctive mitral valve (MV) repair at the time of coronary artery bypass graft surgery (CABG) is beneficial. We sought to test the hypothesis that MV repair with CABG is superior to CABG alone in improving MR without increasing operative or ... |
9,505 | Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation. | Altered conduction is associated with increased atrial fibrillation (AF) vulnerability in canine models of chronic mitral regurgitation (MR) and heart failure (HF). Rotigaptide (ZP123) augments gap junction conductance, improving cell-to-cell coupling. We studied the effects of rotigaptide on atrial conduction and AF v... |
9,506 | Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial. | Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial.</AbstractText>The Optimal Pharmacologi... |
9,507 | Detection of T-wave alternans using an implantable cardioverter-defibrillator. | Microvolt T-wave alternans (TWA) increases acutely prior to ventricular tachycardia (VT) or ventricular fibrillation (VF) in computer simulations and animal models, suggesting that TWA may provide a warning for VT/VF in patients with an implantable cardioverter-defibrillator (ICD).</AbstractText>The purposes of this st... |
9,508 | Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation. | LQTS may cause sudden cardiac death (SCD), but the mechanisms linking gene mutations to ventricular fibrillation (VF) are unclear.</AbstractText>To determine whether ventricular activation delays in congenital long QT syndrome (LQTS) are associated with VF and to describe these delays clinically by measuring activation... |
9,509 | Sudden cardiac arrest in intercollegiate athletes: detailed analysis and outcomes of resuscitation in nine cases. | Public access defibrillation programs have demonstrated a survival benefit in persons with out-of-hospital cardiac arrest. However, little is known about the effectiveness of early defibrillation in young competitive athletes with sudden cardiac arrest (SCA).</AbstractText>The purpose of this study was to investigate t... |
9,510 | A single moving dipole model of ventricular depolarization. | Modeling abnormal depolarization of the ventricles may provide a means to localize sites of arrhythmia foci from the body surface recordings. In this paper, we present a single moving dipole (SMD) model of the ventricular depolarization. The model can reproduce characteristic QRS patterns comparable to the clinical rec... |
9,511 | The utility of implantable loop recorders for diagnosing unexplained syncope in 100 consecutive patients: five-year, single-center experience. | The purpose of this study was to retrospectively review the 5-year experience of a university hospital with implantable loop recorders (ILR) for the diagnosis of recurrent, unexplained syncope or presyncope.</AbstractText>One hundred patients with syncope or presyncope of unknown etiology (negative tilt-table test, ele... |
9,512 | Successful parental use of an automated external defibrillator for an infant with long-QT syndrome. | Congenital long-QT syndrome with 2:1 atrioventricular block presenting in the perinatal period is rare, has a poor prognosis, and leads to high risk for lethal ventricular arrhythmic events. An implantable cardioverter-defibrillator seems to be the most effective treatment in the prevention of arrhythmic sudden cardiac... |
9,513 | Management of cardiovascular risk in patients receiving calcineurin inhibitors--a case report. | Cardiovascular disease is the main cause of death after renal transplantation. There are few trials evaluating the efficacy of prevention strategies in renal transplant patients on major adverse cardiac events (MACE) and cardiovascular mortality. However, there is general agreement that active prevention strategies can... |
9,514 | External reshaping of the left ventricle in off-pump surgery. | : Dyskinetic areas of the lateral and inferior left ventricular (LV) wall are frequently encountered in patients with coronary artery disease. In clinical practice, all of the techniques described for the restoration of shape and function of the LV require cardiopulmonary bypass. A new technique of LV external reshapin... |
9,515 | Inferior wall myocardial infarction with or without right ventricular involvement--treatment and in-hospital course. | Right ventricular infarction (RVI) is most commonly associated with inferior wall infarction (20-50% of cases). Clinical presentation of RVI may vary.</AbstractText>Assessment of outcome and clinical course of myocardial infarction in patients with inferior wall myocardial infarction with or without RVI. Additionally, ... |
9,516 | Reduced survival following resuscitation in patients with documented clinically abnormal observations prior to in-hospital cardiac arrest. | Patients suffering in-hospital cardiac arrest (IHCA) often have abnormal clinical observations documented prior to the arrest. This study assesses whether these patients have a less favourable outcome following IHCA.</AbstractText>A multiple logistic regression analysis of retrospectively collected hospital chart data ... |
9,517 | A moderate dose of propofol and rapidly induced mild hypothermia with extracorporeal lung and heart assist (ECLHA) improve the neurological outcome after prolonged cardiac arrest in dogs. | Propofol has been shown to protect against neuronal damage induced by brain ischaemia in small animal models. We reported previously that mild hypothermia (33 degrees C) in combination with extracorporeal lung and heart assist (ECLHA) improved the neurological outcome in dogs with cardiac arrest (CA) of 15 min induced ... |
9,518 | Inter-rater reliability for witnessed collapse and presence of bystander CPR. | Witnessed collapse and bystander CPR are the variables most frequently associated with good outcome from out-of-hospital cardiac arrest (OOHCA). The reliability of abstracting witnessed collapse and bystander CPR from prehospital Emergency Medical Services (EMS) patient care records (PCRs) is not known. We sought to de... |
9,519 | [Automatic external defibrillator (AED) and public access defibrillation (PAD)]. | Sudden death is a major public hazard and is usually caused by ventricular fibrillation (VF). Although in the majority of cases witnesses are to be found, resuscitation efforts are begun only in a minority of victims. The only treatment for VF is electrical shock and the time from collapse to resuscitation and defibril... |
9,520 | [Patients with recurrent malignant ventricular arrhythmias--therapeutic challenge]. | Patients with malignant refractory ventricular arrhythmias present a unique therapeutic challenge. In recent years, this challenge has become even more complex due to the wide spread use of implantable cardiac defibrillators. If, in the past, a majority of the patients succumbed due to these arrhythmias, today, due to ... |
9,521 | [Intravenous flecainide administration for conversion of paroxysmal atrial fibrillation in the emergency room]. | Since the removal of intravenous propafenone from the Israeli market, flecainide is the only intravenous antiarrhythmic class 1C drug available nowadays in Israel.</AbstractText>The study aimed to report our experience of intravenous flecainide administration in the treatment of paroxysmal atrial fibrillation (PAF) in ... |
9,522 | [Coronary artery surgery in women]. | Cardiovascular diseases are the leading cause of morbidity and mortality for women in developed countries. Numerous studies have shown that women have higher morbidity and mortality rates than men following coronary artery bypass graft surgery (CABG). Having this evidence as our starting point, we compared the outcomes... |
9,523 | [Methods and pharmacology in cardiopulmonary resuscitation. What's new?]. | Initiation of effective cardiopulmonary resuscitation (CPR) at the earliest possible time is the most important determinant of prognosis for patients with prehospital cardiac arrest. Basic life support CPR, defibrillation by emergency medical systems or first responders as well as vasopressor drugs or antiarrhythmics a... |
9,524 | Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data. | Several randomized trials have compared atrial-based (dual-chamber or atrial) pacing with ventricular pacing in patients with bradycardia. No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goal of this review was to determine whether atrial-based pacing prevents major... |
9,525 | Bradycardia-dependent ECG changes in Brugada syndrome. | In patients with Brugada syndrome (BS), ventricular fibrillation (VF) occurs mainly during sleep; therefore, not only vagal activity but also bradycardia dependent changes in ECG may relate to the nighttime occurrence of VF. The present study aimed to examine the difference in bradycardia-dependent changes in the ECG o... |
9,526 | Location of out-of-hospital cardiac arrests in Takatsuki City: where should automated external defibrillator be placed. | Public access defibrillation has been introduced to improve the outcome of patients experiencing out-of-hospital cardiac arrest (OHCA). The aim of this study was to examine the best location for automated external defibrillators (AED).</AbstractText>All patients who were resuscitated after OHCA by emergency medical tec... |
9,527 | Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNP. | To study the determinants of natriuretic peptides in advanced chronic heart failure (CHF) patients with and without atrial fibrillation (AF) and to evaluate the prognostic value of natriuretic peptides in AF compared with sinus rhythm patients with advanced CHF.</AbstractText>The study group comprised 354 advanced CHF ... |
9,528 | Incidence and types of arrhythmias after mediastinal manipulation during transhiatal esophagectomy. | Transhiatal esophagectomy (THE) is a common operative procedure for carcinoma esophagus. Complications of this procedure include arrhythmias and hypotension during blunt dissection of the esophagus from posterior mediastinum. In the literature, exact incidence and type of arrhythmias have not been reported. We employed... |
9,529 | Transapical aortic valve implantation: an animal feasibility study. | Percutaneous aortic valve implantation has recently been performed in nonsurgical patients with severe aortic stenosis. Retrograde valve delivery has been problematic because of the size of the delivery system and concomitant peripheral vascular disease. We investigated a minimally invasive approach through the left ve... |
9,530 | Paroxysmal atrial fibrillation precipitated by amiodarone-induced thyrotoxicosis five months after cessation of therapy. | Amiodarone is currently indicated for the treatment of life-threatening ventricular dysrhythmias. It is also used for the treatment of supraventricular dysrhythmias and as maintenance therapy after successful cardioversion of atrial flutter or atrial fibrillation. Adverse effects related to its expanded use are increas... |
9,531 | Elimination of cardiac arrhythmias using oral taurine with l-arginine with case histories: Hypothesis for nitric oxide stabilization of the sinus node. | We searched for nutrient deficiencies that could cause cardiac arrhythmias [premature atrial contractions (PACs), premature ventricular contractions (PVCs), atrial fibrillation, and related sinus pauses], and found literature support for deficiencies of taurine and l-arginine. Case histories of people with very frequen... |
9,532 | [Pulmonary vein antrum isolation guided by 3-D mapping system in 100 patients with chronic atrial fibrillation]. | To investigate the efficacy and safety of circumferential pulmonary vein (PV) linear ablation (CPVA) guided by 3-D mapping system in patients with chronic atrial fibrillation (CAF).</AbstractText>From August 2004 to November 2005, 100 consecutive patients with CAF were admitted to undergo CPVA guided by CARTO system an... |
9,533 | Cardiac troponin I and ventricular arrhythmia in patients with chronic heart failure. | Both detectable serum cardiac troponin I (cTnI) and ventricular dysrhythmias are common in patients with chronic heart failure (CHF) and are paralleled with the severity of the CHF. However, the relationship between serum cTnI and ventricular arrhythmia severity in patients with CHF remains unknown; the mechanism of th... |
9,534 | Cardiopulmonary resuscitation in a rat model of chronic myocardial ischemia. | Our group has developed a rat model of cardiac arrest and cardiopulmonary resuscitation (CPR). However, the current rat model uses healthy adult animals. In an effort to more closely reproduce the event of cardiac arrest and CPR in humans with chronic coronary disease, a rat model of coronary artery constriction was in... |
9,535 | [Risk stratification in atrial and ventricular arrhythmias]. | Atrial fibrillation, the most frequent arrhythmia, has a growing incidence with increasing age and the most important complication of the disease is thromboembolic events that may be prevented by antivitamin K. They are the most efficient therapeutic class for the prevention of these events but they are associated with... |
9,536 | Cardiac arrhythmias in the intensive care unit. | Cardiac arrhythmias are a common problem encountered in the intensive care unit (ICU) and represent a major source of morbidity. Arrhythmias are most likely to occur in patients with structural heart disease. The inciting factor for an arrhythmia in a given patient may be an insult such as hypoxia, infection, cardiac i... |
9,537 | [Cardiac arrhythmias in women]. | The aim of this study was to review published data on gender differences in cardiac electrophysiology and in the presentation and clinical treatment of arrhythmias. The evidence from studies published to date show that women have a higher mean resting heart rate, a longer QT interval, a shorter QRS duration, and a lowe... |
9,538 | [The implantable cardioverter-defibrillator and hypertrophic cardiomyopathy. Experience at three centers]. | Although implantable cardioverter-defibrillators (ICDs) are recommended for high-risk patients with hypertrophic cardiomyopathy (HCM), there is no agreement on their general use. Moreover, little information is available on ICD use in this setting in Spain. Our aims were to describe the characteristics of HCM patients ... |
9,539 | High titer of anticardiolipin antibody is associated with first-ever ischemic stroke in Taiwan. | The association between anticardiolipin antibody (aCL) and ischemic stroke is controversial, and there are few case-control studies of Asian populations. The aim of this study, therefore, was to determine whether aCL is an independent risk factor for ischemic stroke in Taiwanese patients over the age of 40 years.</Abst... |
9,540 | Potential benefit of transesophageal defibrillation: an experimental evaluation. | Because of the proximity of the esophagus to the heart, transesophageal defibrillation might increase defibrillation success. We assessed the defibrillation threshold (DFT) of transesophageal defibrillation compared with standard transthoracic defibrillation.</AbstractText>Defibrillation success and DFTs were determine... |
9,541 | Suicide due to oral ingestion of lidocaine: a case report and review of the literature. | The Authors describe a rare case of suicide in a 31-year-old woman, due to oral ingestion of lidocaine; the histological and toxicological findings are discussed to provide useful information to the present experience with this particular modality of death. Histological examination revealed generalized stasis. In the m... |
9,542 | [Management of atrial flutter in 2006]. | Typical or common atrial flutter is a frequent cardiac arrhythmia related to a macroreentrant circuit located entirely within the right atrium. Risks associated with this supraventricular arrhythmia include 1 to 1 conduction with extremely rapid ventricular rates, tachycardia-mediated cardiomyopathy and thromboembolic ... |
9,543 | Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans. | Analysis of repolarization instability, manifested by T-wave alternans (TWA), has proved useful for arrhythmia risk assessment. However, temporal relations between TWA and the spontaneous initiation of ventricular tachyarrhythmias (VTA) in humans are unknown. We examined continuous dynamics of repolarization in Holter ... |
9,544 | Atrial secretion of B-type natriuretic peptide. | In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricula... |
9,545 | Reduced effectiveness of hypothermia in patients lacking the wave V in auditory brainstem responses immediately following resuscitation from cardiac arrest. | Therapeutic hypothermia appears to improve the outcome of pre-hospital cardio-pulmonary arrest (CPA) in patients with an initial cardiac rhythm of ventricular fibrillation or nonperfusing ventricular tachycardia (VF/VT). Notwithstanding, the outcome of this procedure is certainly difficult to predict based solely on th... |
9,546 | Determinants of thoracic electrical impedance in external electrical cardioversion of atrial fibrillation. | The success of external cardioversion (ECV) of atrial fibrillation depends on generating sufficient transmyocardial current for defibrillation with minimal myocardial injury. Thoracic electrical impedance plays an important role in the relation between the delivered energy and transmyocardial current. This study assess... |
9,547 | A coroner's request for closure: the value of the stored electrogram. | Pacemaker diagnostics can be useful to troubleshoot both during life and after death. A 58-year old man with a single chamber ventricular pacemaker and a previous His bundle ablation died suddenly. Interrogation of his pacemaker revealed the cause of death not as pacemaker malfunction, but a fatal ventricular arrhythmi... |
9,548 | Discordant regulation of CRP and NT-proBNP plasma levels after electrical cardioversion of persistent atrial fibrillation. | B-type natriuretic peptide (BNP) and C-reactive protein (CRP) have been suggested to be prognostically relevant markers in patients with cardiovascular disease. Additionally, BNP and CRP plasma levels seem to be independently elevated in patients with atrial fibrillation (AF). However, there are only sparse data about ... |
9,549 | Outcomes and predictors of success of a radiofrequency- or cryothermy-simplified left-sided maze procedure in patients undergoing mitral valve surgery. | Restoration of sinus rhythm with a maze procedure after concomitant mitral valve (MV) surgery has been shown to reduce the rate of stroke and improve cardiac function and quality of life compared to MV surgery alone. Unlike the classical Cox-Maze III operation, a simplified left-sided maze procedure can be performed wi... |
9,550 | Cardiopulmonary exercise testing determination of functional capacity in mitral regurgitation: physiologic and outcome implications. | This study was designed to evaluate prevalence, determinants, and clinical outcome implications of reduced functional capacity (FC) in patients with organic mitral regurgitation (MR).</AbstractText>Evaluation of FC by exercise testing is rarely performed in MR because little is known about the clinical determinants and... |
9,551 | [Influence of age-related complications on clinical outcome in patients with surgical repair of atrial septal defect]. | The influence of perioperative characteristics on postoperative outcome has been obscure in the adult patients with atrial septal defect (ASD). This study was designed to investigate whether perioperative patient profiles and complications will contribute to postoperative outcome following surgical closure of ASD in ad... |
9,552 | Heart failure and diabetes: left ventricular systolic function. | Heart failure is the main cause of mortality and morbidity in general population, annual mortality rate is 20%, in spite of pharmacological treatments or other therapies. Cardio-vascular events and diabetes tight correlation is well known, while it is less evaluated diabetes and heart failure correlation is less studie... |
9,553 | Brugada electrocardiographic pattern due to tricyclic antidepressant overdose. | The Brugada syndrome is an arrhythmogenic disease with characteristic coved ST-segment elevation 2 mm or greater in the right precordial leads (type 1 Brugada electrocardiogram [ECG] pattern or "Brugada sign"] and is estimated to be responsible for at least 20% of sudden deaths in patients with structurally normal hear... |
9,554 | Shortening of the ventricular fibrillatory intervals after administration of verapamil in a patient with Brugada syndrome and vasospastic angina. | A 43-year-old man presented with electrocardiographic findings consistent with Brugada syndrome. Though the baseline coronary angiogram was normal, intracoronary infusion of ergonovine maleate caused complete occlusion of the left anterior descending and a 99% occlusion of the proximal right coronary artery, each relie... |
9,555 | Beat-to-beat variations of the electrocardiogram in survivors of sudden death without structural heart disease. | We sought to determine whether survivors of sudden death without structural heart disease have beat-to-beat electrocardiographic (ECG) characteristics at the microvolt and at the millisecond level that differ from normal subjects.</AbstractText>We studied patients at our implantable cardioverter defibrillator clinic wh... |
9,556 | [Time distribution of ventricular arrhythmias in patients with Brugada syndrome]. | To study the characterization of time distribution of ventricular arrhythmias in patients with Brugada syndrome (BrS) using Holter monitoring and ICD follow-up.</AbstractText>Patients with BrS [all male, mean age (41.07 +/- 11.49) years], were divided into ventricular fibrillation (VF) group (n = 7) and no ventricular ... |
9,557 | Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/Akt pathway in canine hearts. | Recent studies suggest that G-CSF prevents cardiac remodeling following myocardial infarction (MI) likely through regeneration of the myocardium and coronary vessels. However, it remains unclear whether G-CSF administered at the onset of reperfusion prevents ischemia/reperfusion injury in the acute phase. We investigat... |
9,558 | Mechanism by which activation of delta-opioid receptor reduces the severity of postresuscitation myocardial dysfunction. | Postresuscitation myocardial dysfunction has been recognized as a leading cause of early death after initially successful cardiopulmonary resuscitation. We have previously demonstrated that opening adenosine triphosphate (ATP)-sensitive K (KATP) channels or activation of delta-opioid receptors minimized the severity of... |
9,559 | Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. | Very-long-chain n-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish are thought to reduce risk of sudden death, possibly by reducing susceptibility to cardiac arrhythmia.</AbstractText>To study the effect of supplemental fish oil vs placebo on ventricular tachyarrhythmia or death.</AbstractText><AbstractText Labe... |
9,560 | Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. | Mild hypothermia improves outcome when induced after cardiac arrest in humans. Recent studies in both dogs and mice suggest that induction of mild hypothermia during cardiopulmonary resuscitation (CPR) greatly enhances its efficacy. In this study, we evaluate the time window for the beneficial effect of intra-arrest co... |
9,561 | Dual-chamber versus single-chamber detection enhancements for implantable defibrillator rhythm diagnosis: the detect supraventricular tachycardia study. | Delivery of inappropriate shocks caused by misdetection of supraventricular tachycardia (SVT) remains a substantial complication of implanted cardioverter/defibrillator (ICD) therapy. Whether use of optimally programmed dual-chamber ICDs lowers this risk compared with that in single-chamber ICDs is not clear.</Abstract... |
9,562 | Hyperviscosity as a possible risk factor for cerebral ischemic complications in atrial fibrillation patients. | Recent studies have suggested that hyperviscosity is frequent in patients with atrial fibrillation (AF). The aims of this study were to evaluate if hemorheologic alterations play a role in the occurrence of cerebral ischemic events in patients with AF and to explore a possible association between inflammation and hyper... |
9,563 | Relation of right ventricular peak systolic pressure to major adverse events in patients undergoing cardiac resynchronization therapy. | The degree to which increased right-sided heart pressures influence outcome in cardiac resynchronization therapy (CRT) is unclear. High right ventricular (RV) pressures may contribute to septal malpositioning, thus hindering effective resynchronization. We hypothesized that patients with high RV systolic pressures befo... |
9,564 | Short-term triple therapy with aspirin, warfarin, and a thienopyridine among patients undergoing percutaneous coronary intervention. | To assess bleeding complications among patients undergoing percutaneous coronary intervention (PCI) and receiving triple therapy of warfarin, aspirin, and a thienopyridine.</AbstractText>Triple therapy of warfarin, aspirin, and a thienopyridine is strongly discouraged, given the potential risk of bleeding complications... |
9,565 | The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). | Endothelin is elevated in heart failure and contributes to neurohormonal activation, hemodynamic deterioration, and cardiovascular remodeling. Here, we examined its prognostic value in a large population of patients with chronic heart failure.</AbstractText>Big endothelin-1 (Big ET-1) and 4 other neurohormones were mea... |
9,566 | Energy doses for treatment of out-of-hospital pediatric ventricular fibrillation. | To investigate the energy dose used to treat out-of-hospital pediatric ventricular fibrillation and the survival rates of these patients.</AbstractText>We reviewed three emergency medical systems (EMS) for their reports of patients under 1 month to 18 years who received shocks for ventricular fibrillation to determine ... |
9,567 | General anesthesia with thoracic epidural anesthesia in the cardiopulmonary bypass surgery reduces apoptosis by upregulating antiapoptotic protein Bcl-2. | The aim of the paper was to investigate whether thoracic epidural anesthesia (TEA) together with general anaesthesia (GA) play a role on apoptosis in humans before cardiopulmonary bypass (CPB), before aortic cross clamp (ACC) and at 15 min after ACC release (after ischemia and reperfusion).</AbstractText>Eighty patient... |
9,568 | Thromboembolic complications in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. | Incidence and clinical presentation of thromboembolic complications in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) were analysed. In reports on ARVD/C, thromboembolism is rarely mentioned. The possible risk factors are: right ventricle (RV) dilatation, aneurysms, and wall motion abn... |
9,569 | Sudden cardiac death: directing the scope of resuscitation towards the heart and brain. | The fundamental goal of cardiopulmonary resuscitation (CPR) is recovery of the heart and the brain. This is best achieved by (1) immediate CPR for coronary and cerebral perfusion, (2) correction of the cause of cardiac arrest, and (3) controlled cardioplegic cardiac reperfusion. Failure of such an integrated therapy ma... |
9,570 | Cigarette smoking and the risk of supraventricular and ventricular tachyarrhythmias in high-risk cardiac patients with implantable cardioverter defibrillators. | Nicotine elevates serum catecholamine concentration and is therefore potentially arrhythmogenic. However, the effect of cigarette smoking on arrhythmic risk in coronary heart disease patients is not well established.</AbstractText>The risk of appropriate and inappropriate defibrillator therapy by smoking status was ana... |
9,571 | Delayed enhancement cardiac MR imaging in noncompaction of left ventricular myocardium. | A 49-year-old female with a history of paroxysmal atrial fibrillation, presented with worsening dyspnea on minimal exertion. During the follow-up period, transthoracic echocardiography and cardiac magnetic resonance imaging (CMR) were consistent with the diagnosis of noncompaction of the left ventricle. Delayed-enhance... |
9,572 | Systolic outward motion of the left ventricular apical wall as detected by magnetic resonance tagging in patients with apical hypertrophic cardiomyopathy. | Patients with apical hypertrophic cardiomyopathy (APH) associated with paradoxic jet flow (ie, diastolic flow away from the apex) may gradually develop an apical aneurysm, which often leads to arrhythmia and mural thrombus formation. We observed systolic outward motion of the left ventricular apical myocardium in patie... |
9,573 | Risk factors for atrial fibrillation in adult patients in long-term observation following surgical closure of atrial septal defect type II. | The aim of the study was to find the factors predictive for paroxysmal atrial fibrillation (AF) following surgical correction of atrial septal defect type II (ASD t.II).</AbstractText>93 patients, who underwent isolated surgical closure of ASD t.II between 1990 and 2001 were included. Follow-up studies were performed 2... |
9,574 | Sudden death is associated with a widened paced QRS complex in noncoronary cardiac disease. | Recent experimental and clinical trials have provided evidence that increased duration of right ventricular electrogram in response to premature extrastimuli correlates with the risk of ventricular fibrillation in noncoronary heart disease. The aim of the present study was to investigate the duration of the surface QRS... |
9,575 | Clinical trials, the renin angiotensin system and atrial fibrillation. | Atrial fibrillation is the most common clinical arrhythmia. Current treatment strategies are far from optimal. One new research direction is to target the atrial fibrillation substrate and to examine whether drugs can produce atrial structural and/or electrophysiological remodeling and whether this results in a reducti... |
9,576 | One-shock versus three-shock defibrillation protocol significantly improves outcome in a porcine model of prolonged ventricular fibrillation cardiac arrest. | The success of resuscitation with a 1-shock versus the conventional 3-shock defibrillation protocol was investigated subject to the range of treatment variation imposed by automated external defibrillators (AEDs).</AbstractText>Ventricular fibrillation was induced in 44 domestic pigs. After 7 minutes of untreated VF, a... |
9,577 | Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. | Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from SD in relation to other recognized clinical risk markers is unknown.</AbstractText>A total of 917 patients with HCM (554 males, 43+/-15 years... |
9,578 | [Acute myocardial infarction complicated by cardiogenic shock. Difficult decision concerning long-distance transportation to a tertiary centre -- a case report]. | A case of a 60-year-old female with acute myocardial infarction complicated by cardiogenic shock is presented. The patient received thrombolytic therapy, however, developed cardiogenic shock and required resuscitation with intubation, mechanical ventilation and repeated defibrillation due to recurrent ventricular fibri... |
9,579 | Percutaneous coronary intervention for cardiac arrest secondary to ST-elevation acute myocardial infarction. Influence of immediate paramedical/medical assistance on clinical outcome. | Patients with cardiac arrest have been excluded from most randomized trials on percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).</AbstractText>The aim of the study was to evaluate the outcome of patients undergoing primary PCI for acute myocardial infarction who suffered from cardiac arres... |
9,580 | Clinical outcomes in patients undergoing elective coronary artery bypass graft surgery with and without utilization of pulmonary artery catheter-generated data. | The purpose of this study was to determine the frequency of pulmonary artery catheter (PAC) quantitative data requirements for modifying patient management during and after elective coronary artery bypass graft (CABG) surgery.</AbstractText>A prospective observational clinical trial.</AbstractText>University tertiary r... |
9,581 | Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST). | We evaluated the impact of treatment crossovers on study results in the Mode Selection Trial (MOST).</AbstractText>The MOST study, a 2,010-patient, 6-year trial comparing dual-chamber pacing (DDDR) and ventricular pacing (VVIR) in sinus node dysfunction, demonstrated no difference in death or stroke and modest reductio... |
9,582 | Valvular aortic stenosis: disease severity and timing of intervention. | Standard echocardiographic evaluation of aortic stenosis (AS) severity includes measurement of aortic velocity, mean transaortic pressure gradient, and continuity equation valve area. Although these measures are adequate for decision making in most patients, there is no single value that defines severe stenosis. Aortic... |
9,583 | Costs, clinical outcomes, and health-related quality of life of off-pump vs. on-pump coronary bypass surgery. | Off-pump coronary bypass surgery avoids the potential complications of cardiopulmonary bypass. However, its acceptance depends on medical and economic outcome. The aim of this prospective non-randomised study was to compare functional and economic outcome of off-pump and on-pump surgery at 1-year follow-up.</AbstractTe... |
9,584 | Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias. | Radiofrequency catheter ablation or modification of the atrio-ventricular junction is an effective therapy of drug refractory supraventricular tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during nonsustained STs. We aimed to examine the effect of sustained STs and the applied rate-control therapy ... |
9,585 | Implantable cardiac arrhythmia devices--part I: pacemakers. | Implantable cardiac devices have become firmly entrenched as important therapeutic tools for a variety of cardiac conditions. The first part of this two-part review will discuss the contemporary use and follow-up of pacemakers, while the second part will address the use of implantable cardioverter defibrillators and im... |
9,586 | [Short QT Syndromes]. | The inherited short QT syndrome (SQTS) is a novel, genetically determined arrhythmia that resembles the pathophysiological counterpart of congenital long QT syndrome (LQTS). Gain-of-function ion channel mutations in cardiac potassium channel genes are the currently known cause of SQTS and obvious genetic heterogeneity ... |
9,587 | [Morphology and function of the intrinsic cardiac nervous system]. | Access to the intrinsic cardiac autonomic nervous system can now be achieved via percutaneous catheter stimulation techniques. Thereby, cardiac functions like atrioventricular nodal conduction, sinus cycle length and ventricular inotropy can be dynamically regulated. The present article provides examples of this new te... |
9,588 | Outcomes of in-hospital ventricular fibrillation in children. | Ventricular fibrillation and ventricular tachycardia are less common causes of cardiac arrest in children than in adults. These tachyarrhythmias can also begin during cardiopulmonary resuscitation (CPR), presumably as reperfusion arrhythmias. We determined whether the outcome is better for initial than for subsequent v... |
9,589 | Protective effects of Ping-Lv-Mixture (PLM), a medicinal formula on arrhythmias induced by myocardial ischemia-reperfusion. | Ping-Lv-Mixture (PLM) is a Chinese medicinal formula. The present study aimed to determine the effects of PLM on myocardial ischemia-reperfusion (MI/R) induced arrhythmias in rats. Arrhythmia model was established by occlusion of the left arterial descending coronary artery and thereafter reperfusion. A lead II electro... |
9,590 | Diastolic heart failure in the elderly and the potential role of aldosterone antagonists. | The overall incidence of heart failure increases with age, affecting up to 10% of people >65 years of age. Diastolic heart failure is also age-dependent, increasing from <15% in middle-aged patients to >40% in patients > or =70 years of age. Elderly patients usually have other co-morbid conditions such as h... |
9,591 | The effects of altering time delays of coupled pacing during acute atrial fibrillation. | Coupled pacing (CP), which consists of delivering a premature electrical stimulation to the heart after the effective refractory period of ventricular activation, is a novel method for controlling ventricular rate during atrial fibrillation (AF). It also has been established that CP improves pump function by enhancing ... |
9,592 | Importance of spatiotemporal heterogeneity of cellular restitution in mechanism of arrhythmogenic discordant alternans. | Spatially discordant cellular alternans form a substrate for development of unidirectional block and ventricular fibrillation. However, the mechanisms responsible for discordant alternans remain poorly understood. Previous work suggests electrical restitution is critical to the development of alternans in single cells.... |
9,593 | Coronary sinus electrode does not reduce atrial defibrillation thresholds. | Atrial defibrillation can be achieved with a conventional dual-coil, active pectoral implantable cardioverter-defibrillator (ICD) lead system. Shocking vectors that incorporate an additional electrode in the CS have been used, but it is unclear if they improve atrial DFTs.</AbstractText>The objective of this prospectiv... |
9,594 | Extramedullary hematopoiesis-related pleural effusion: the case of beta-thalassemia. | Thalassemia intermedia has a later clinical onset and a milder anemia than thalassemia major, characterized by high output state, left ventricle remodeling, and age-related pulmonary hypertension. Bone deformities, extramedullary hematopoiesis (EMH), and spleen and liver enlargement are the consequences of hypoxia and ... |
9,595 | Non-compaction cardiomyopathy in an adult with hereditary spherocytosis. | A 23-year old male (199 cm, 88 kg) presented muscular weakness due to skeletal myopathy and symptoms of heart failure NYHA functional class II. Total creatine kinase was increased up to 830 U/l, but troponin was negative. Prior episodes of intermittent atrial fibrillation were reported and 6 years ago splenectomy was p... |
9,596 | Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation. | It is well known that vagal nerve tone plays a crucial role in atrial fibrillation (AF). Acetylcholine-activated potassium current (IKACh) mediates much of the cardiac response to vagal nerve stimulation (VNS), but the contribution of IKACh to AF remains unknown. We investigated the role of the IKACh channel in canine ... |
9,597 | Underlying cardiomyopathy in patients with ST-segment elevation in the right precordial leads. | Ventricular fibrillation (VF) and sudden death (SD) may occur in patients with ST-segment elevation in the right precordial leads. The mechanism of such events is unclear, so the aim of the present study was to assess whether there is an underlying morphological or pathological abnormality in these patients.</AbstractT... |
9,598 | Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter. | Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL). However, serious adverse effects, including torsade de pointes (Tdp), have been reported.</AbstractText>Adverse effects of Bpd requiring discontinuation of treatment were evaluated. Bpd was a... |
9,599 | A knowledge-based method for reducing attenuation artefacts caused by cardiac appliances in myocardial PET/CT. | Attenuation artefacts due to implanted cardiac defibrillator leads have previously been shown to adversely impact cardiac PET/CT imaging. In this study, the severity of the problem is characterized, and an image-based method is described which reduces the resulting artefact in PET. Automatic implantable cardioverter de... |
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