PMID
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36.4M
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36,296,728
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chang chemic composit flaxse oil thermal induc oxid result effect dsc thermal properti investig chang chemic composit flaxse oil thermal induc oxid result effect thermal properti sampl differ oxid level obtain heat c two hour four hour oxid degre evalu use peroxid valu pv extinct coeffici nm nm k k total polar compound tpc use chromatographi fatti acid profil triacylglycerol tag profil examin differenti scan calorimetri dsc use determin crystal melt profil thermal induc oxid flaxse oil led signific increas p lt pv k k tpc relat content linolen acid ln lnlnln reduc dramat p lt tpc deriv lipid degrad affect crystal melt profil statist correl show onset temperatur ton crystal curv high correl k tpc relat content lnlnln p lt wherea offset temperatur toff melt curv high correl relat content fatti acid p lt find provid new way rapid evalu oxid level chang chemic composit flaxse oil use dsc
|
D008043;D010938
|
T121;T168;T123;T109
|
36,296,727
|
euodia daniellii hemsl extract activ compon hesperidin acceler cutan wound heal via activ wnt catenin signal pathway activ wnt catenin signal pathway play key role wound heal process tissu regener extract euodia daniellii hemsl e daniellii member rutacea famili activ wnt catenin signal pathway howev function e daniellii wound heal yet elucid perform migrat assay determin wound heal effect e daniellii extract vitro use human keratinocyt dermal fibroblast addit mous acut wound model use investig cutan wound heal effect e daniellii extract vivo confirm potenti mechan e daniellii extract enhanc migrat human keratinocyt dermal fibroblast via activ wnt catenin pathway moreov e daniellii extract increas level keratin pcna collagen sma nuclei accumul catenin vitro e daniellii extract also effici acceler epitheli stimul wound heal vivo furthermor confirm hesperidin one compon e daniellii effici acceler migrat human keratinocyt dermal fibroblast well wound heal vivo via activ wnt catenin pathway overal e daniellii extract activ compon hesperidin potenti use therapeut agent wound heal
|
D006569;D032086
|
T121;T002;T127;T109
|
36,296,726
|
alkaloid deriv z ethylamino pregn en inhibit tripl negat breast cancer metastasi angiogenesi target hsp metastasi import caus cancer relat death previous studi laboratori found pregnan alkaloid pachysandra terminali antimetastat activ breast cancer cell current studi demonstr treatment one alkaloid deriv z ethylamino pregn en led downregul hif vegfvegfr pathway suppress phosphoryl downstream molecul akt mtor fak inhibit breast cancer metastasi angiogenesi vitro vivo furthermor antimetastasi antiangiogenesi effect treatment mgkg effect sorafenib mgkg surfac plasmon reson spr analysi perform result suggest hsp direct target taken togeth result suggest compound might repres candid antitumor agent metastat breast cancer
|
D064726;D000970;D000470
|
T121;T123;T109;T131;T191
|
36,296,725
|
polyacrylonitrileamin polymer nanospher nanofib effici adsorb cr vi remov work polyacrylonitrileamin polymer nanospher panapn nanofib prepar electrospin monodispers amin polymer nanospher apn remov cr vi aqueous solut character result show obtain panapn possess nitrogen function furthermor adsorpt applic result indic panapn nanofib exhibit high adsorpt capac mgg k cr vi remov kinet data show adsorpt process fit pseudo second order thermodynam studi reveal adsorpt cr vi spontan endotherm coexist ion na ca k cl po littl influenc cr vi adsorpt solut dramat decreas remov perform investig remov mechan relat result indic adsorpt behavior possibl involv electrostat adsorpt redox reaction chelat panapn nanofib detoxifi cr vi cr iii subsequ chelat cr iii surfac uniqu structur nitrogen function panapn nanofib make novel prospect candid heavi metal remov
|
D057139;D054118;D014874;D019216
|
T131;T196;T073
|
36,296,723
|
synthesi identif new n n disubstitut thiourea thiazolidinon scaffold base quinolon moieti ureas inhibitor synthesi thiazolidinon base quinolon moieti establish start hydroxyquinol one strategi start reaction ethyl bromoacet hydroxyquinolin give correspond ethyl oxoquinolinyl acet react hydrazin hydrat afford hydrazid deriv subsequ hydrazid react isothiocyan deriv give correspond n n disubstitut thiourea final subject n n disubstitut thiourea dialkyl acetylenedicarboxyl cyclize occur thiazolidinon deriv obtain good yield two seri base quinolon moieti one contain n n disubstitut thiourea contain thiazolidinon function screen vitro ureas inhibit properti use thiourea acetohydroxam acid standard inhibitor inhibit valu synthes thiourea thiazolidinon exhibit moder good inhibitori effect structur activ relationship reveal n methyl quinolonyl moieti exhibit superior effect sinc prove potent inhibitor present seri achiev ic previous compound exhibit relat much greater activ approxim fold potent thiourea acetohydroxam acid refer molecular dock analysi show good protein ligand interact profil ureas target pdbid ubp emphas electron geometr effect n n disubstitut thiourea
|
D014510;D015363
|
T126;T116;T109
|
36,296,722
|
volatil organ compound profil cystoseira corniculata turner zanardini ericaria amentacea cagardh molinari guiri ex cystoseira amentacea cagardh bori de saint vincent volatil organ compound voc fresh frcc air dri drcc cystoseria corniculata fresh frea air dri drea ericaria amentacea adriat sea investig headspac solid phase microextract hs spme hydrodistil hd analys gas chromatographi mass spectrometri gc ms hs frcc hs drcc aliphat compound domin decan ol abund hs frcc hs drcc pentadecan domin monoterpen cyclocitr citral cyclohomocitr sesquiterpen cubenol abund hs frcc notabl differ fresh air dri sampl found benzen deriv fatti acid deriv abund hd frcc hd drcc hs frea hs drea satur aliphat compound well unsatur aliphat compound particular hexan ol z hex en ol predomin show decrement dri pentadecan heptadecan pentadecan hexan ol predomin hd frea percentag decreas hd drea percentag monoterpen decreas dri percentag diterpen especi sesquiterpen increas selinen major terpen abund hd drea signific increment dri could notic fatti acid deriv great divers identifi voc among two macroalga support differ botan classif
|
D055549;D000459;D012717
|
T204;T109
|
36,296,721
|
hydrazin hydrazon adamantin compound show antimycobacteri activ probabl inhibitor mmpl tuberculosi remain import caus morbid mortal throughout world notabl import number multi drug resist case increas concern problem point urgent need novel compound antimycobacteri properti improv exist therapi whole cell base screen compound activ mycobacterium tuberculosi complex strain presenc linezolid perform studi set bioactiv compound antimycobacteri activ vitro identifi minim inhibitori concentr less gml among compound small molecul chemic structur consist adamantan moieti hydrazid hydrazon moieti whole genom sequenc spontan mutant resist compound suggest compound new inhibitor mmpl compound bind pocket alreadi publish mmpl inhibitor without disturb proton motiv forc bovi bcg smegmati compound show strong activ panel ofclin strain tuberculosi vitro compound show toxic mammalian cell protect galleria mellonella larva bovi bcg infect result suggest compound promis anti tb agent potenti improv tb treatment combin standard tb therapi
|
D009169;D014376;D000218
|
T047;T007;T109
|
36,296,720
|
synthesi vitro anti microbi analysi molecular dock studi aliphat hydrazid base benzen sulphonamid deriv potent inhibitor glucosidas ureas uniqu seri sulphonamid deriv attempt synthes studi use new effect method synthes compound verifi use sever spectroscop method includ ftir h nmr c nmr hrei ms bind interact studi use molecular dock enzym ureas glucosidas evalu deriv compar respect standard drug acarbos thiourea almost compound shown excel activ among screen seri analog ic ic emerg potent molecul compar standard drug acarbos ic ureas ic moreov anti microbi studi also demonstr analog found minimum inhibitori concentr mic presenc standard drug streptomycin terinafin
|
D000520;D014510
|
T121;T126;T116
|
36,296,719
|
new process sulfon algalpei biosorb enhanc sr ii remov aqueous solut applic seawat sulfon resin high effici cation exchang wide use metal remov aqueous solut herein new sulfon process design sulfon algalpei composit pei reaction propylen sulfon acid hydroxylamin sulfon acid new sulfon function sorbent sa pei success test batch system strontium recoveri first synthet solut investig multi compon solut final valid seawat sampl chemic modif pei tripl sorption capac sr ii ph remov rate pei sa pei respect sd g l ftir show strong contribut sulfon group function sorbent addit amin carboxyl group support sorption endotherm increas sorption temperatur sulfon improv thermal stabil slight enhanc textur properti may explain fast kinet control pseudo first order rate equat sulfon sorbent show remark prefer sr ii competitor mono di tri valent metal cation sorption properti weak influenc excess nacl explain outstand sorption properti treatment seawat sampl addit sulfon sorbent show excel stabil recycl least cycl loss capac around preliminari result show remark effici sorbent sr ii remov complex solut could open perspect treatment contamin seawat sampl
|
D014874
|
T131
|
36,296,718
|
molecular recognit fda approv small molecul protein kinas drug protein kinas protein kinas key enzym catalyz coval phosphoryl substrat via transfer phosphat atp play crucial role cellular prolifer differenti various cell regulatori process due pivot cellular role aberr function kinas associ cancer mani diseas consequ competit inhibit atp bind site protein kinas emerg effect mean cure diseas decad intens develop protein kinas inhibitor pkis result fda approv pki drug target dozen protein kinas treatment various diseas fda approv protein kinas inhibitor pki drug compet atp bind pocket central question attempt address work base mode non bond interact calcul interact strength mean advanc doubl hybrid dft method bplyp molecular recognit pki drug atp bind pocket systemat analyz found fda approv pki drug studi form one hydrogen bond backbon amid n atom hing region atp bind site mimick adenin base fda approv pki drug featur two aromat ring latter reach far deep hydrophob region ii form multipl ch interact aliphat residu l v v g l stack interact aromat residu f f atp util region extens fda approv pki drug studi one thing common ie frequent form non bond interact total residu l v k e v f g l f atp bind mani common involv residu high conserv residu import structur catalyt function role k e two high conserv residu crucial catalyt function kinas f belong dfg motif dub gate keeper residu f locat hing region g sit linker connect hing helix target high conserv residu protein kinas led promiscu pki drug lack select although format hydrogen bond backbon hing give pki drug ad bind affin much need direct select sacrif mani fda approv pki drug known multipl target moreov target mediat toxic caus lack select one major challeng face pki drug discoveri communiti work suggest road map futur pki drug design ie target non conserv residu atp bind pocket gain better select avoid target mediat toxic
|
D011494;D047428
|
T121;T126;T116
|
36,296,717
|
review cyanid gas elimin method materi cyanid gas high toxic volatil among typic toxic harm pollut human health environ found industri wast gas militari context cyanid gas use system toxic agent paper review cyanid gas elimin method focus adsorpt catalysi approach research progress materi capabl affect cyanid gas adsorpt catalyt degrad discuss depth advantag disadvantag various materi summar final suggest provid futur research direct respect cyanid gas elimin materi
|
D003486;D004785
|
T131;T197
|
36,296,716
|
insight aggreg hen egg white lysozym raman spectroscopi md simul protein misfold aggreg play signific role sever neurodegen diseas present work spontan aggreg hen egg white lysozym hewl alkalin ph ambient temperatur studi obtain molecular insight time depend chang spectral peak indic format sheet effect backbon amino acid aggreg process introduc iodoacetamid reveal crucial role intermolecular disulphid bond amidst monom aggreg process find corrobor molecular dynam md simul protein dock studi md simul help establish visual unfold protein expos alkalin ph protein dock reveal preferenti dimer format hewl monom ph compar neutral ph combin raman spectroscopi md simul power tool studi protein aggreg mechan
|
D009113;D056004
|
T121;T116;T066;T126;T044
|
36,296,715
|
amomum tsao ko essenti oil inhibit inflamm apoptosi pjnk mapk signal pathway allevi gentamicin induc acut kidney injuri clinic applic gentamicin may lead acut kidney injuri aki nephrotox gentamicin relat patholog mechan sever oxid inflammatori cytokin plant deriv essenti oil good anti inflammatori antioxid properti studi aim clarifi protect effect amomum tsao ko essenti oil ao gentamicin induc aki rat possibl mechan rat aki model induc intraperiton inject gentamicin day oral ao treatment renal function patholog chang kidney tissu evalu level kidney tissu oxid stress detect content inflammatori cytokin measur elisa express erk jnk p nf b caspas baxbcl protein estim western blot analysi result show take ao reduc content serum urea creatinin aki rat improv patholog chang oxid stress kidney tissu rat time ao reduc inflamm apoptosi aki regul mapk pathway data show ao protect effect kidney may potenti drug treat kidney injuri
|
D035801;D009822;D058186
|
T047;T037;T002;T109
|
36,296,714
|
understand antilymphoma activ annona macroprophyllata donn acycl terpenoid vivo vitro silico studi annona macroprophyllata donn macroprophyllata use tradit mexican medicin treatment cancer diabet inflamm pain work evalu antitumor activ three acycl terpenoid obtain macroprophyllata assess potenti antilymphoma agent identifi terpenoid farnesyl acet fa phytol pt geranylgeraniol gg use gas chromatographi mass spectroscopi gc ms spectroscop h c nmr method appli petroleum ether extract leav macroprophyllata peam investig antitumor potenti balbc mice inocul u cell assess brine shrimp lethal bsl cytotox activ cell addit assess potenti toxic peam fa pt gg human test acut oral toxic mice result show three terpenoid exhibit consider antilymphoma cytotox activ term lethal determin median lethal dose ld thirteen isol product peam gg pt af exhibit higher lethal valu g ml respect assess cytotox activ u cell calcul mean cytotox concentr cc found fa pt closer respect control drug methotrex mtx term antilymphoma activ found fa pt gg consider inhibit lymph node growth median effect dose ed mg kg femal mg kg male respect regard acut oral toxic classifi three terpenoid categori iv indic high safeti margin human administr final molecular dock studi hydroxi methylglutaryl coenzym hmg coa reductas found bind terpenoid amino acid catalyt site suggest effect upon activ result decreas synthesi intermedi involv prenyl protein involv cancer progress find suggest acycl terpenoid fa pt gg may serv scaffold develop new treatment non hodgkin lymphoma
|
D031041;D000970
|
T121;T002;T109
|
36,296,713
|
bioactiv platinum iv complex incorpor halogen phenylacet new seri cytotox platinum iv complex incorpor halogen phenylacet acid deriv chlorophenylacet acid fluorophenylacet acid bromophenylacet acid iodophenylacet acid synthesis characteris use spectroscop spectrometr techniqu complex assess panel cell line includ ht colon u glioblastoma mcf breast ovarian h lung skin du prostat c neuroblastoma sj g glioblastoma mia pancrea addp resist ovarian variant non tumour deriv mcfa breast line vitro cytotox result confirm superior biolog activ studi complex especi contain fluorophenylacet acid bromophenylacet acid ligand name elicit averag gi valu nm rang cell line test du prostat cell line exhibit highest degre potenc amongst deriv display gi valu nm make fold potent cisplatin nm near fold potent lead complex mess nm cell line notabl addp resist ovarian variant cell line nm found almost fold potent cisplatin reduct reaction experi also undertaken along studi aim determin complex solubl stabil lipophil reactiv oxygen speci product
|
D005909;D010051;D000970
|
T121;T191;T109
|
36,296,712
|
phytochem composit vitro antioxid anti inflammatori anticanc enzym inhibitori activ artemisia nilagirica cb clark pamp plant employ therapeut applic various infecti chronic diseas ancient time various tradit medicin folk system util numer plant plant product act sourc drug candid modern medicin artemisia genus asteracea famili speci howev mani speci less explor biolog efficaci sever other lack scientif explan use artemisia nilagirica plant wide found western ghat kerala india promin member genus current studi phytochem composit antioxid enzym inhibitori anti inflammatori anticanc activ examin result indic ethanol extract nilagirica indic vitro dpph scaveng gml abt scaveng gml h scaveng gml frap gml anti inflammatori effect also notic raw macrophag pretreat extract reduc lps stimul product cytokin p lt nilagirica also effici inhibit activ amylas gml glucosidas gml aldos reductas gml sorbitol dehydrogenas gml also induc signific inhibit prolifer breast mcf ic mdamb ic gml colon gml cancer cell result phytochem screen indic higher level polyphenol flavonoid extract lcms analysi reveal presenc various bioactiv constitu includ artemisinin
|
D019306;D037621
|
T002;T109
|
36,296,711
|
heparin superparamagnet iron oxid nanoparticl theranost applic studi superparamagnet iron oxid nanoparticl spion engin organ coat compos low molecular weight heparin lmwh bovin serum albumin bsa provid heparin base nanoparticl system lmwh spion purpos merg properti heparin skeleton inorgan core build target theranost nanosystem eventu enhanc load chemotherapeut agent iron oxid core prepar via co precipit iron salt alkalin environ oleic acid oa cap dopamin da coval link bsa lmwh amid linkag via carbodiimid coupl follow ligand exchang reaction da bsada lmwh oa conduct biphas system compos water hexan afford lmwh spion stabil water polystyren sulfon pss size morpholog investig via dynam light scatter dls transmiss electron microscopi tem respect lmwh spion cytotox test show margin toxic sampl prepar pss concentr gml inhibitori activ heparanas enzym measur show effect inhibit concentr compar g n desulfo n acetyl heparin non anticoagul antiheparanas heparin deriv roneparstat lmwh spion encapsul paclitaxel ptx enhanc antitumor effect chemotherapeut breast cancer cell like due improv intern nanoformul drug respect free molecul last time domain nmr td nmr experi conduct lmwh spion obtain relax valu within order magnitud current use commerci contrast agent
|
D058185;D053758
|
T130;T073
|
36,296,710
|
potenti neuroprotect effect cyperus esculentus l extract scopolamin induc cognit impair rat extens biolog metabolom approach aim present studi investig phytochem composit tiger nut tn cyperus esculentus l neuroprotect potenti scopolamin scop induc cognit impair rat uhplc esi qtof ms analysi enabl putat annot metabolit saccharid amino acid organ acid fatti acid phenol compound flavonoid treatment tn extract restor scop induc learn memori impair parallel tn extract succeed lower amyloid beta secretas protein express acetylcholin esteras ach activ hippocampus rat tn extract decreas malondialdehyd level restor antioxid level reduc proinflammatori cytokin well baxbcl ratio histopatholog analysi demonstr mark neuroprotect tn treat group conclus present studi reveal tn extract attenu scop induc memori impair diminish amyloid beta aggreg well anti inflammatori antioxid anti apoptot anti ach activ
|
D029786;D018696;D060825
|
T121;T169;T002;T048
|
36,296,709
|
combin therapi carnos acid methotrex effect suppress inflammatori marker oxid stress experiment arthriti combin therapi methotrex mtx common therapeut strategi use treatment patient rheumatoid arthriti ra studi combin natur compound carnos acid ca mtx reduc inflamm oxid stress adjuv arthriti aa
|
D001169;D001172
|
T047;T050
|
36,296,708
|
bioanalyt method develop valid stabil assess xanthohumol rat plasma xanthohumol xh prenyl chalcon divers therapeut effect various diseas present studi bioanalyt method develop xh rat plasma use revers phase high perform liquid chromatographi valid method perform per ich guidelin use curcumin intern standard isocrat elut method use run time min wherein mobil phase ratio v v opa methanol b v v flow rate mlmin inject volum l chromatogram xh curcumin record wavelength nm retent time xh curcumin min respect spike xh plasma extract protein precipit method develop method linear r valu concentr rang ngml along lloq result valid paramet found within accept limit rsd valu less percentag recoveri found greater base rsd percentag recoveri result confirm method precis accur among studi replic lod loq valu plasma sampl found ngml ngml respect stabil studi like freez thaw short term long term stabil studi also perform rsd percentag recoveri xh plasma sampl within accept limit therefor develop bioanalyt method use effect estim xh plasma sampl
|
D047188;D003474
|
T121;T130;T109
|
36,296,707
|
identif natur compound inhibitor pyruv kinas cancer treatment relianc tumor cell aerob glycolysi one emerg hallmark cancer pyruv kinas pkm import enzym glycolyt pathway high express number cancer cell tumor cell heavili depend pkm fulfil diverg energet biosynthet requir suggest novel drug target cancer therapi base context perform enzymat assay base screen hous phenol compound librari identif pkm inhibitor screen identifi silibinin curcumin resveratrol ellag acid potenti inhibitor pkm ic valu respect determin ki constant inhibit type hit compound lineweav burk graph plot silibinin ellag acid perform competit inhibit pkm ki constant curcumin resveratrol identifi non competit inhibitor pkm ki constant silico screen phenol compound three bind site pkm provid insight bind pattern function import amino residu pkm evalu cytotox via mtt assay demonstr ellag acid potent inhibitor cancer cell growth ic result present ellag acid silibinin curcumin resveratrol inhibitor pkm interrog metabol reprogram cancer cell studi also provid foundat research valid potenti identifi bioactiv entiti pkm target cancer therapi
|
D003474;D015470
|
T121;T191;T130;T109
|
36,296,705
|
recoveri terephthal acid densifi post consum plastic mix htl process studi investig hydrotherm liquefact htl pet separ densifi postconsum plastic mix aim recov monom second raw materi made polyolefin remain made pet trace metal paper glass preliminari separ densiti water two batch experi perform sunken fraction compos main pet stainless steel autoclav c min trial result similar yield three phase particular solid yield around weight purif step phase analyz uv vis h nmr ftir spectroscopi result constitut terephthal acid tpa product consider industri interest studi prove hydrotherm liquefact process coupl densiti separ water effect obtain tpa densifi postconsum plastic mix use new pet synthesi
|
D010969;D010795
|
T167;T109
|
36,296,704
|
research progress hypoglycem mechan resist starch review recent year preval diabet rise global resist starch rs known kind promis dietari fiber prevent treatment diabet therefor becom hot topic explor hypoglycem mechan rs review mechan summar accord relev studi recent year general blood glucos could regul rs regul intestin microbiota disord resist digest reduc inflamm regul hypoglycem relat enzym mechan although exact mechan benefici effect rs fulli verifi indic rs use daili dietari intervent reduc risk diabet differ way addit research hypoglycem mechan rs impact rs categori differ experiment anim various dietari habit human subject also discuss review
|
D007004;D003920
|
T121;T039;T047
|
36,296,703
|
chemoprevent effect human colon adenocarcinoma cell styrylquinolin synthesi cytotox proapoptot effect molecular dock analysi seven styrylquinolin synthes studi two styrylquinolin new elucid spectroscop analysi chemoprevent potenti compound evalu sw human colon adenocarcinoma cell metastat deriv sw normal cell hacat accord result compound show antiprolif activ sw sw cell effect seem caus differ mechan action compound induc apoptosi independ ros product evidenc increas level caspas immunomodulatori effect posit regul product differ immunolog marker malign cell line contrast compound generat pro oxid respons inhibit growth cancer cell probabl anoth type cell death apoptosi molecular dock studi indic activ compound could effici bind proapoptot human caspas protein result could provid valuabl inform biochem mechan vitro cytotox respons compound sw colon carcinoma cell line obtain result suggest compound chemoprevent potenti crc studi carri elucid molecular mechan action depth
|
D003110;D000230;D016588;D000970
|
T121;T039;T191;T109
|
36,296,702
|
select plant deriv polyphenol potenti therapeut agent peripher arteri diseas molecular mechan efficaci safeti vascular diseas peripher arteri diseas pad associ diabet mellitus higher risk cardiovascular diseas even death surgic revascular pharmacolog treatment main antiplatelet lipid lower drug antidiabet agent effect respons efficaci therapi over depend patient condit thus demand new cure exist regard new studi natur polyphenol act key point involv pathogenesi vascular diseas thus pad great urgenc purpos review take account mechan lead endothelium dysfunct glycoxid process product advanc glycat end product age result protein misfold suggest plant deriv polyphenol could use pad thus five polyphenol consid baicalein curcumin mangiferin quercetin resveratrol review literatur pubm key molecular mechan preclin clinic studi select compound examin furthermor safeti profil polyphenol outlin togeth unwant effect report human also search databas vigibas
|
D003474;D058729
|
T121;T047;T130;T109
|
36,296,701
|
gallomyrtucommulon g h new phloroglucinol glycosid bioactiv fraction myrtus communi staphylococcus speci myrtacea famili continu sourc antimicrobi agent search novel antimicrobi agent staphylococcus speci bioactiv fraction myrtus communi l grow sardinia island itali investig phytochem analysi led us isol character four alkylphloroglucinol glycosid three gallomyrtucommulon g h myrtucommulonosid isol character first time structur new known compound endopreroxid g myricetin glycosid determin base spectroscop evid includ nmr hr ms spectrometri enrich fraction well pure compound test antimicrobi activ broth micro dilut assay staphylococcus epidermidi aureus result report herein demonstr gallomyrtucommulon g show select antimicrobi activ aureus strain atcc gml gallomyrtucommulon show best growth inhibit valu gml
|
D031651;D000890
|
T121;T002
|
36,296,700
|
antioxid biolog activ lotus root polysaccharid iron iii complex studi synthesi paramet lotus root polysaccharid iron complex lrpf determin optim respons surfac methodolog optimum prepar condit ph solut ratio trisodium citrat lotus root polysaccharid reaction time h uv spectroscopi thermogravimetri ft ir spectroscopi x ray diffract cd nmr use character lrpf lrpf good stabil easili releas iron ion artifici gastrointestin condit lrpf exhibit antioxid activ vitro signific improv antioxid activ vivo addit lrpf good effect treatment iron defici anemia model mice impact gut microbiom reduc iron defici induc pernici regul steroid hormon biosynthesi therefor lrpf use nutrit supplement treat prevent iron defici anemia improv human immun
|
D000975;D018798
|
T123;T121;T039;T044;T047
|
36,296,699
|
optim hplc dad methodolog determin anthocyanin grape skin red greek winegrap cultivar viti vinifera l rapid simpl hplc dad analyt method develop optim determin anthocynanin three red greek winegrap varieti kotsifali limnio vradiano critic paramet acidifi solvent extract temperatur affect extract anthocyanin grape studi find optimum valu develop methodolog valid term select linear accuraci precis present satisfactori result limit quantif loq rang mgkg mgkg limit detect lod rang mgkg mgkg rsd within day day assay lower respect show adequ precis accuraci rang within day assay day assay sixteen sampl main region varieti well offici ampelograph collect greec collect grow season analyz hplc dad notabl differ anthocyanin content detect among cultivar use hierarch cluster analysi hca
|
D027843
|
T129;T168;T116;T002
|
36,296,698
|
mno mediat oxid cyclize formal schiff base easi access divers naphthofuro annul triazin differ type mno induc oxid cyclize dihydrotriazin develop dihydrotriazin consid formal schiff base method provid easi access naphthofuro fuse triazin via c cc oxid coupl reaction reaction sequenc compris nucleophil addit naphthol phenol triazin follow oxid cyclize scope limit novel coupl reaction investig applic synthes compound demonstr synthes carbazol substitut benzofuro fuse triazin scalabl reaction demonstr mmol load mechanist studi strong suggest reaction proceed format coordin manganes complex
|
D012545;D014227
|
T109
|
36,296,697
|
silico method identif potenti activ site therapeut target target identif import step drug discoveri comput aid drug target identif method attract attent compar tradit drug target identif method time consum cost comput aid drug target identif method great reduc search scope experiment target associ cost identifi diseas relat target bind site evalu druggabl predict activ site clinic trial review introduc principl comput base activ site identif method includ identif bind site assess druggabl provid guidelin select method identif bind site assess druggabl addit list databas tool common use method present exampl individu combin applic compar method tool final discuss challeng limit bind site identif druggabl assess current stage provid recommend futur perspect
|
D055808
|
T062
|
36,296,696
|
synthesi anticanc antioxid anti inflammatori antimicrobi activ molecular dock dft studi sultam deriv saccharin seri n substitut saccharin name dioxido oxobenzo isothiazol h yl acetonitril alkyl dioxido oxobenzo isothiazol h yl acet g synthes moder excel yield commerci avail start materi two differ approach chemic structur character spectroscop techniqu h nmr c nmr ir ms synthes compound evalu anti inflammatori toward il tnf antioxid well anticanc activ hepat cancer cell addit anti fungal antibacteri activ gram posit gram negat bacteria test test compound exhibit excel e moder anti inflammatori activ addit ester b f nitril show excel antioxid activ furthermor ester f isopropyl ester exhibit highest cytotox activ compar ester moreov compound evalu select inhibitor human cox enzym use molecular dock calcul free energi bind inhibit constant paramet find bind affin molecular studi show ester f nitril reveal highest bind affin henc enhanc inhibit activ activ site cox enzym test compound negat gibb free electrostat total intermolecular energi standard inhibitor asa result indic test sultam potent anti inflammatori drug compar standard inhibitor final chemic properti quantum factor synthes sultam calcul base densiti function theori dft predict reactiv correl experiment data ester f show lowest ionize potenti lowest energi gap e gap ev correl cytotox activ furthermor spatial electron distribut homo lumo comput clear indic electron donat abil test compound
|
D000975;D000970
|
T123;T121;T109;T039;T044
|
36,296,695
|
chemic composit antioxid antimicrobi activ leav ajuga iva main object research studi biolog characterist term antioxid antimicrobi activ ajuga iva determin best analyt extract method applic speci studi compound short screen nutrit valu term chemic composit also includ iva leav analyz crude protein cp cell wall neutral deterg fiber ndf acid deterg fiber adf acid deterg lignin adl miner fatti acid essenti oil phenol compound matur aerial part iva random collect spring season mogran zaghouan tunisia leav iva contain cp ndf adf adl miner content main compos potassium g dm magnesium dm leav iva linolen linol acid main compon acid profil thymol found domin essenti oil follow vinylguaiacol linalool hplc pda esi msms analysi point presenc phytoecdysteroid phenol acid flavonoid glycosyl deriv naringenin eriodyctiol apigenin detect methanol extract iva leav result underlin import choos proper extract method solvent extract character describ compound profil iva leav result also show iva leav potenti sourc function ingredi benefici health promot properti overal leav iva low biolog activ antioxid antimicrobi activ chemic composit suitabl feed rumin rangeland pastur also low grade antibacteri medicin characterist fed rumin
|
D031328;D009822
|
T002;T109
|
36,296,694
|
phytochemistri bioactiv metabolit tradit use fagopyrum tataricum tartari buckwheat fagopyrum tataricum edibl part main grain sprout tartari buckwheat contain protect substanc make possibl plant surviv high altitud strong natur ultraviolet radiat divers high content phenol substanc import tartari buckwheat grow reproduc unfriend environment effect diseas graze substanc main flavonoid rutin quercetin quercitrin vitexin catechin epicatechin epicatechin gallat phenol acid fagopyrin emodin synthesi protect substanc depend genet layout environment condit main uv radiat temperatur flavonoid glycosid among tartari buckwheat plant bioactiv metabolit flavonoid compound special interest due antioxid properti potenti prevent tired diabet mellitus oxid stress neurodegen disord parkinson diseas process product food item tartari buckwheat metabolit subject molecular transform main tartari buckwheat tradit food product bread groat sprout
|
D019612;D002392;D004642
|
T121;T123;T109;T168;T002
|
36,296,693
|
antiglioma natur product marin associ fungus penicillium sp zz marin deriv penicillium fungi one import sourc discoveri new bioactiv natur product studi character isol structur antiglioma activ twelv compound includ three novel one penipyridinon b penilloid r e penilloid marin fungus penicillium sp zz structur novel compound determin via extens nuclear magnet reson nmr spectroscop analys high resolut electrospray ionize mass spectroscopi hresim data mosher method optic rotat calcul electron circular dichroism ecd calcul penipyridinon b repres first exampl structur type show potent antiglioma activ ic valu umg cell u cell known compound questiomycin xanthocillin x also show antiprolif activ umg u cell ic valu antiglioma activ questiomycin xanthocillin x may relat promot reactiv oxygen speci ros product reduct mitochondri membran potenti mmp enhanc caspas enzym activ
|
D010407;D001688
|
T123;T121;T004
|
36,296,692
|
anticholinesteras activ select medicin plant navarra region spain detail phytochem investig origanum vulgar l ssp vulgar alzheim diseas neurodegen diseas character progress memori loss cognit impair due sever loss cholinerg neuron specif brain area common type dementia age popul although mani anti acetylcholinesteras ach drug alreadi avail market perform sometim yield unexpect result reason research work ongo find potenti anti ach agent natur synthet sourc studi extract nativ natur medicin plant test tlc ellman colorimetr assay gml order determin inhibitori effect ach total extract show high anti ach activ inhibit dose depend manner among ethanol extract aerial part vulgar ssp vulgar show ic valu time lower galantamin research also establish chemic profil oregano extract tlc hplc dad lc ms twenti three compound identifi quantifi dihydroxycinnam acid flavonoid abund one respect final total phenol compound antioxid properti quantifi colorimetr method total phenol content gmg extract antioxid activ measur two radic dpph abt assay oregano extract show high activ pearson correl matrix show relationship syring acid type dihydroxybenzo acid anti ach r antioxid activ r conclus result studi demonstr promis potenti new use medicin herb treatment alzheim origanum vulgar ssp vulgar syring acid anti ach activ benefici antioxid capac highlight potenti candid develop drug treatment alzheim diseas diseas character cholinerg deficit
|
D031341;D010946;D000544;D019636
|
T168;T047;T002;T048
|
36,296,691
|
reaction trifluorotriacet acid lacton hexafluorodehydroacet acid amin synthesi trifluoromethyl pyridon aminoenon dehydroacet acid triacet acid lacton known versatil substrat synthesi varieti azaheterocycl howev fluorin analog poor describ literatur present work investig reaction trifluorotriacet acid lacton hexafluorodehydroacet acid primari amin phenylenediamin phenylhydrazin hexafluorodehydroacet acid react way non fluorin analog give bis trifluoromethyl pyridon trifluorotriacet acid lacton differ regioselect nucleophil attack compar parent structur correspond amino trifluoro oxohex eneamid form product case binucleophil cyclize took place form correspond benzodiazepin pyrazol obtain bis trifluoromethyl pyridon abl react activ methylen compound give fluorin merocyanin dye
|
D000588;D007783
|
T109
|
36,296,690
|
copper ii complex contain fluorophenoxyacet acid hydrazid phenanthrolin prostat cancer cell select low toxic copper ii compound prostat cancer pca second lead caus cancer relat death among men worldwid treatment advanc case base chemotherapi lack specif efficaci due sever side effect resist tradit drug copper complex shown antitumor efficaci low toxic consid promis class metal base drug treatment malign neoplasm thus present studi aim evalu cellular effect copper ii complex fluorophenoxyacet acid hydrazid phenanthrolin pca cell line well mutagenicrecombinogen anticarcinogen potenti drosophila melanogast pnt non tumorigen lncap hormon respons pca pc androgen independ pca cell cultur cytotox assess use mtt assay express level prolifer marker ki cyclin analyz flow cytometri furthermor somat mutat recombin test smart epitheli tumor test ett perform complex select lncap cell signific reduc ki cyclin express level sub toxic concentr complex defin toxic test melanogast mutagenicrecombinogeniccarcinogen effect observ anticarcinogen potenti observ melanogast suggest modul activ complex doxorubicin drug use control carcinogen properti therefor complex possibl start point develop new antitumor agent treatment pca
|
D011471;D000970
|
T121;T191;T109
|
36,296,689
|
bioaccess betalain beetroot beta vulgari l juic differ high pressur techniqu influenc high hydrostat pressur hhp supercrit carbon dioxid sccd bioaccess betalain beetroot beta vulgari l juic investig fresh squeez juic fj treat mild temperatur c min pasteur c min hhp mpa c min hhp hhp hhp sccd mpa c min sccd sccd sccd juic subject vitro digest system equip dialysi content betalain measur aid high perform liquid chromatographi hplc antioxid capac ac abt dpph analyz digest step bioaccess betacyanin betaxanthin assess sccd mpa signific increas pigment bioaccess compar sampl mpa prove particular advantag increas bioaccess total betacyanin betaxanthin respect compar sampl addit higher bioaccess betacyanin note hhp hhp respect compar fj sampl ac measur abt dpph assay unequivoc howev assay show signific higher ac sccd compar respect research contribut extend use hhp andor sccd design food higher health promot potenti
|
D050858;D027461
|
T123;T168;T002;T109
|
36,296,688
|
prepar process optim perform character feed plant essenti oil microcapsul explor safe antibiot substitut one research hotspot anim husbandri ad suitabl plant essenti oil feed could improv growth perform immun capac anim order make plant essenti oil play better role feed applic sodium algin chitosan use wall materi blend plant essenti oil beo core materi prepar beo microcapsul sharp hole condens method basi singl factor experi optim prepar condit beo microcapsul obtain respons surfac experi physicochem properti character analyz fourier transform infrar spectroscopi ftir field scan electron microscop fsem meanwhil releas mechan studi simul gastrointestin sustain releas experi result show optim prepar condit encapsul effici beo microcapsul could reach ftir sem analysi display microcapsul obtain uniform color size complet compact structur vitro studi indic releas amount beo microcapsul simul intestin fluid higher simul intestin fluid consist anim digest absorpt characterist
|
D009822;D048271
|
T121;T109
|
36,296,687
|
optim jinhua ham classif method base volatil flavor substanc determin key odor biomark jinhua ham tradit cure meat food china long time grade main evalu human nose three stick method high subject conduc establish evalu standard odor marker paper analyz well grade grade iii ham provid jinzi ham co ltd jinhua china first use differ extract fiber extract temperatur extract time determin optim condit headspac solid phase microextract hs spme aroma compon jinhua ham analyz headspac solid phase microextract combin gas chromatographi mass spectrometri gc ms oav calcul screen key aroma volatil three kind jinhua ham found total compon detect three type ham among kind key aroma volatil aldehyd alcohol acid three main compon jinhua ham content aldehyd gradual decreas grade grade iii ham content acid gradual increas specul increas acid content caus prolifer microorgan grade iii ham key flavor volatil grade ham hexan methylbutan grade ham strong meat aroma pleasant fatti roast aroma without flavor grade ii ham characterist volatil e e decadien ethyl isovaler detect two volatil contribut great flavor grade ii ham make flavor grade ii ham special fruiti aroma also may prone sour affect flavor ham volatil low threshold valu pyrazin furan sulfur contain compound relat high grade iii ham may also contribut poorer flavor qualiti grade iii ham experi provid reliabl test method evalu basi rate jinhua ham result posit implic establish odor marker base grade criteria
|
D000080305;D055549
|
T168;T109
|
36,296,686
|
acetylcholinesteras inhibitori activ essenti oil vietnames tradit medicin plant essenti oil promis environment friend safe sourc pesticid human use furthermor also interest aromatherapeut agent treatment alzheim diseas inhibit enzym acetylcholinesteras ach evalu import mechan essenti oil speci genera callicarpa premna vitex karomia famili lamiacea evalu inhibit electr eel ach use ellman method essenti oil callicarpa candican show promis activ ic valu gml essenti oil callicarpa sinuata callicarpa petelotii callicarpa nudiflora callicarpa erioclona vitex ajugifolia show good activ ic valu gml essenti oil vitex trifolia subsp trifolia callicarpa rubella show modest activ ic valu respect tran carveol show ic valu gml molecular dock molecular dynam simul perform major compon studi essenti oil investig possibl mechan action potenti inhibitor result obtain suggest essenti oil may use control mosquito vector transmit pathogen virus support treatment alzheim diseas
|
D009822;D010946;D000544;D019686;D020950;D032408;D010575
|
T109;T168;T131;T047;T002;T048
|
36,296,685
|
promot co crystal poli butylen succin poli butylen fumar blend via end group function co crystal play crucial role integr regul thermal mechan properti polym blend poor compat compon crystal phase alway major obstacl co crystal put forward stricter request linkag interact differ entiti basi hydrogen bond interact promot chain stack thus improv miscibl propos crystallinecrystallin blend ureido h pyrimidinon upi function poli butylen succin poli butylen fumar pbs upypbf upi upi group quadrupl hydrogen bond interact employ connect differ chain end could inhibit phase separ improv co crystal pbs upypbf upi blend exhibit complex compon depend cool rate depend co crystal behavior high level co crystal occur rang pbs upi rich fraction proport could approach optim condit aid upi quadrupl hydrogen bond interact work enrich understand co crystal crystallinecrystallin polym blend provid possibl design structur properti polym materi
|
D005650;D011108
|
T121;T122;T104;T109
|
36,296,684
|
dephas process molecular dye lumogen f orang character two dimension electron spectroscopi molecular dye find applic photon quantum technolog polariton optic microcav organ quantum batteri singl photon emitt quantum sens metrolog applic crucial import character dephas mechan work use two dimension electron spectroscopi des studi temperatur depend dephas process prototyp organ dye lumogen f orang model des map use bloch equat two level system obtain dephas time fs room temperatur increas fs k furthermor spectral diffus process observ model combin underdamp overdamp brownian oscil result provid use design paramet advanc optoelectron photon devic incorpor dye molecul
|
D004396;D032084
|
T109;T168;T197;T130;T002
|
36,296,683
|
method rapid screen biolog activ compound present plant base extract recent year increas interest product natur origin extract procedur bioactiv compound plant matric crucial step develop use new bioproduct everyday life utilis analys enabl rapid identif presenc given group compound help earli stage develop new product order save time reduc cost within articl present comparison differ access method identif various bioactiv compound eg saponin carboxyl acid oil fat protein amino acid steroid alkaloid plant base extract addit multielement composit extract also examin appli method allow confirm presenc biolog activ compound bio product obtain ultrasound assist extract later stage procedur supplement advanc analyt techniqu order determin plant chemic content qualit quantit
|
D012503;D000470
|
T123;T121;T131;T109
|
36,296,682
|
mechan regul microglia polar intracerebr hemorrhag intracerebr hemorrhag ich lethal subtyp stroke effect treatment lack neuroinflamm play key role pathogenesi innat immun respons cerebr hemorrhag microglia first appear around injur tissu involv inflammatori cascad respons microglia respond acut brain injuri activ polar either typic like pro inflammatori altern like anti inflammatori phenotyp two polar state produc pro inflammatori anti inflammatori discoveri molecular mechan key signal molecul relat polar microglia brain target regul polar microglia reduc inflammatori respons consid treatment secondari brain tissu ich damag effect strategi therefor promot polar microglia phenotyp ich becom focus attent recent year articl review mechan action microglia phenotyp secondari brain injuri ich moreov discuss compound natur pharmaceut ingredi polar phenotyp
|
D020521;D001930
|
T047;T037
|
36,296,681
|
honey propoli engin collagen peptid promis wound heal matrix mous model studi collagen hydrolys chds fabric honey propoli wax hpw structur modifi spong matrix experiment wound heal mous model scaffold character mean vitro enzymat degrad vitro hpw releas vivo wound heal mous model wound heal specif rna transcript protein marker function activ hpw extract raw propoli determin use total flavonoid antioxid scaveng assay anti hemolyt principl result indic hpw high flavonoid content gml wax antioxid activ effect concentr ec hpw estim mgml use subsequ vivo experi addit dop mixtur chds hpw substanti enhanc wound heal process regul wound biochem marker hexoseamin melondialdehyd chds hpw upregul express growth factor includ vascular endotheli growth factor vegf fold fibroblast growth factor fgf epiderm growth factor egf fold transform growth factor beta tgf fold indic potenti capac perform wound epitheli load ground tissu pro inflammatori marker il pgml tnf pgml signific reduc chd hpw treat wound interest result confirm use mrna protein growth factor wound enhanc load collagen wound site conclus chds hpw exhibit signific reduct inflamm inflammatori marker help obtain faster wound heal process mous model newli engin biospong could develop promis therapeut approach regener repair damag human skin futur
|
D011429;D006722
|
T123;T121;T168
|
36,296,680
|
evalu human osteoblast nip micro pattern pcl carrier contain nanohydroxyapatit reduc graphen oxid use psm content surfac topolog tissu engin scaffold two import paramet regul cell behavior studi phase separ micromold psm method implement develop micro groov imprint poli caprolacton pcl nano hydroxyapatit nhap reduc graphen oxid rgo ternari blend construct physic chemic character cell devoid construct perform ftir xrd tga dsc poros swell wettabl analysi tensil compress mechan test vitro biolog perform human osteoblast cultur micro pattern blend construct evalu mtt alamarblu viabil assay find reveal nhap rgo signific promot cell viabil prolifer micro pattern determin direct cell migrat alkalin phosphatas ca analys carri determin osteogen properti cell laden construct studi describ simpl method generat topolog modifi ternari blend pclnhaprgo construct use psm method contribut cell prolifer migrat particular import regen medicin
|
D011091;D000469
|
T122;T126;T116;T109
|
36,296,679
|
structur predict character canavalia grandiflora congf lectin complex mmp unveil antiglioma potenti legum lectin glioblastoma gbm high malign primari brain tumor poor prognosi invas high resist current therapi gbms abnorm glycosyl pattern associ malign allow use lectin tool recognit therapi specif lectin interact glycan structur found malign cell surfac context present work aim investig antiglioma potenti congf lectin purifi canavalia grandiflora seed c cell treatment c cell congf impair mitochondri transmembran potenti reduc cell viabil induc morpholog chang congf also induc massiv autophagi evalu acridin orang ao stain lcab ii express without promin propidium iodid pi label mechan action appear involv carbohydr bind capac congf silico studi suggest lectin interact glycan structur matrix metalloproteinas mmp promin protein found malign cell like explain observ effect
|
D032449;D007887
|
T002
|
36,296,678
|
polygonatum cyrtonema hua polysaccharid protect bv microglia relief oxid stress ferroptosi regul nrfho pathway neuron regul cell death rcd due accumul ros within central nervous system cns one crucial caus central system diseas caspas depend apoptosi form rcd research progress sever nonapoptot cell death pathway rcds identifi ferroptosi nonapoptot rcd character lipid peroxid plasma membran damag polygonatum cyrtonema hua polysaccharid pcp effect antioxid base protect effect mechan pcp h induc microgli injuri investig furthermor protect mechan pcp ferroptosi microglia explor result indic pcp could reduc oxid stress induc ros accumul activ nrfho signal pathway thus attenu rcd microglia subsequ studi reveal pcp allevi ferroptosi microglia due protein level erastinrsl inhibitor slcagpx activ nrfho signal pathway therefor hypothes pcp exert antioxid anti ferroptosi effect activ express nrfho pathway facilit new idea clinic effect prevent treatment diseas due accumul reactiv oxygen speci cns simultan pcp develop potenti new drug candid treat cns diseas
|
D051267;D031384
|
T123;T116;T002
|
36,296,677
|
dad net classif alzheim diseas use adasyn oversampl techniqu optim neural network alzheim diseas ad neurolog brain disord caus dementia neurolog dysfunct affect memori behavior cognit deep learn dl kind artifici intellig ai pave way new ad detect autom method dl model predict accuraci depend dataset size dl model lose accuraci dataset imbalanc class problem studi aim use deep convolut neural network cnn develop reliabl effici method identifi alzheim diseas use mri studi offer new cnn architectur diagnos alzheim diseas modest number paramet make perfect train smaller dataset propos model correct separ earli stage alzheim diseas display class activ pattern brain heat map propos detect alzheim diseas network dad net develop scratch correct classifi phase alzheim diseas reduc paramet comput cost kaggl mri imag dataset sever problem class imbal therefor use synthet oversampl techniqu distribut imag throughout class avoid problem precis recal f score area curv auc loss use compar propos dad net demenet cnn model accuraci auc f score precis recal dad net achiev follow valu evalu metric respect present dad net outperform state art model evalu metric accord simul result
|
D000544
|
T047;T048
|
36,296,676
|
inhibit glucosidas amylas protein glycat phenol extract cotoneast bullatus cotoneast zabelii cotoneast integerrimus leav fruit focus anti hyperglycem activ kinet paramet cotoneast speci gain signific import tradit asian medicin abil prevent treat hyperglycemia diabet therefor studi aspect benefici health effect hydromethanol extract c bullatus c zabelii c integerrimus leav fruit evalu includ influenc glucosidas amylas nonenzymat protein glycat activ investig relat polyphenol profil extract determin uv spectrophotometr hplc pda fingerprint method reveal leaf fruit extract promis sourc biolog compon caffeic acid pseudodepsid proanthocyanidin flavonol leaf extract c bullatus c zabelii contain highest level polyphenol mgg total respect leaf extract also effect inhibitor digest enzym nonenzymat protein glycat ic valu gml obtain activ leaf extract c bullatus mbl glucosidas amylas glycat inhibit test respect kinet studi mbl display mix type inhibitor enzym correl polyphenol profil activ paramet r gt p lt indic signific contribut proanthocyanidin test activ result support tradit use cotoneast leav fruit diabet suggest hydrophil extract promis function applic
|
D044945;D027824;D003920
|
T121;T047;T002;T109
|
36,296,675
|
review crystallin multibridg cyclophan cage synthesi conform behavior properti paper review stabl conform crystallin three dimension cyclophan cp achiev self assembl base chang type aromat compound regul type number bridg group n cyclophan cps report form supramolecular compound bind organ inorgan anion neutral molecul select n cyclophan n cps stronger donor capabl relat compound n cyclophan n cps expect new type electron donor progress fresh electron conduct materi synthesi conform behavior properti crystallin multi bridg ring summar discuss
|
D008968
|
T082
|
36,296,674
|
hkust go hkust rgo composit impact synthesi method physicochem properti chemic stabil adsorptivecatalyt properti wide studi metal organ framework mof hkust improv combin graphen oxid go reduc graphen oxid rgo chemistri go rgo surfac signific impact interact mof work demonstr go rgo interact hkust influenc morpholog textur properti impact thermal stabil final composit also show synthesi environ eg stir extent influenc format hkust go hkust rgo composit homogen sampl sandwich type composit obtain use reduc graphen oxid decor copper curgo owe presenc cu site allow direct crystallis hkust growth graphen surfac work first part research hkust go hkust rgo deal influenc type graphen materi synthesi paramet composit physicochem properti determin use x ray diffract scan transmiss electron microscopi fourier transform infrar spectroscopi x ray photoelectron spectroscopi thermogravimetr analysi
|
D006108;D000073396
|
T196;T109
|
36,296,673
|
natur compound product anti age perspect age complex process accompani degen impair mani major function human bodi time inevit process influenc hereditari factor lifestyl environment influenc xenobiot pollut infecti agent uv radiat diet born toxin mani extern intern sign symptom relat age process senesc includ skin dryness wrinkl atherosclerosi diabet neurodegen disord cancer etc oxid stress consequ imbal pro antioxid one main provok factor caus age relat damag concern due generat high reactiv byproduct reactiv oxygen nitrogen speci metabol result cellular damag apoptosi antioxid prevent process extend healthi longev due abil inhibit format free radic interrupt propag therebi lower level oxid stress review focus support antioxid system organ balanc diet consumpt necessari amount natur ingredi includ vitamin miner polyunsatur fatti acid pufa essenti amino acid probiot plant fiber nutrit supplement polyphenol phytoextract drink water
|
D000975;D060766
|
T123;T121;T044;T039;T167
|
36,296,672
|
ultrasensit detect cu ii pb ii use water solubl perylen probe select detect metal ion water use sustain detect system crescent import monitor water environ drink water safeti one key element futur chemic scienc use sustain approach design new materi studi design synthes low cost water solubl potassium salt perylen tetracarboxyl acid ptas show select optic respons addit cu pb ion aqueous solut use water solubl chromophor interact metal ion definit intim effici respect standard method employ cosolv detect limit ptas cu pb found use simpl absorb mode even lower nmr experi indic analyt probe system sensit enough detect copper ion drink water lead ion wast water complex ptas ion support nmr studi reveal format new speci ptas analyt combin low cost water solubl chromophor effici analyt probe interact due use aqueous solut result obtain provid basi design sustain sens system
|
D010569;D060766
|
T131;T130;T167;T109
|
36,296,671
|
photocatalyt degrad dye use titania nanoparticl support metal organ materi base iron composit materi base titania nanoparticl tio nps three metal organ framework mof call mil fe fe iii oh bdc mil materi institut lavoisi mil fe fe h oh btc fe btc iron benzenetricarboxyl differ percentag tio nps wt synthes use solvotherm method use photocatalyt materi degrad two dye orang ii reactiv black rb pristin composit materi character x ray diffract raman uv vis fourier transform infrar spectroscopi scan electron microscopi techniqu tio mil composit materi show best result degrad dye reactiv black orang ii dye degrad min respect incorpor tio nps mof decreas recombin chang carrier mof increas photocatalyt activ pristin mof result therefor indic synthes mof nanocomposit good potenti wastewat treatment
|
D000073396;D053758
|
T073;T109
|
36,296,670
|
reagent control high stereoselect difluoromethyl effici access chiral difluoromethylamin ketimin reagent control high stereoselect reaction difluoromethyl phenyl sulfoximin imin report synthet method provid varieti enantiomer enrich difluoromethyl amin main pros approach includ high effici high stereoselect broad substrat scope probabl achiev non chelat transit state
|
D007097;D000588
|
T109
|
36,296,669
|
molecular simul effect cyclic organ compound stabil lccbm hydrat ch separ low concentr coal bed methan lccbm use hydrat base gas separ hbgs method studi contribut differ cyclic organ compound separ ch lccbm lccbm hydrat model construct base mont carlo molecular dynam theori simul effect three cyclic organ compound cyclopentan cp cyclopentanon cp one cyclopentanol cp ol stabil lccbm hydrat p mpa various temperatur discuss structur stabil hydrat depth term final snapshot radial distribut function mean squar displac diffus coeffici potenti energi chang result show ch n lccmm gas mixtur cp show best facilit effect compar two cyclic compound maintain stabil lccbm hydrat well k promot effect cp one cp cp ol temperatur increas k oxygen atom water molecul maintain essenti stabil hydrat structur although orderli decreas signific moreov structur hydrat model contain cp ol destroy k eventu escap ch n molecul solut occur bubbl research result import explor mechan action cyclic promot molecul lccbm hydrat molecul promot prefer
|
D002245;D008697
|
T123;T197;T109
|
36,296,666
|
adalin adalia genus ladybird potent antagonist insect specif mammalian nicotin acetylcholin receptor ladybird beetl coleoptera coccinellida possess strong chemic defenc secret respons stress also found coat egg rich alkaloid respons toxic speci recent studi shown alkaloid sever speci ladybird beetl target nicotin acetylcholin receptor nachr act receptor antagonist explor action adalin found spot adalia bipunctata spot adalia decempunctata ladybird mammalian insect nachr use patch clamp te cell locust brain neuron nativ express nachr well two electrod voltag clamp xenopus laevi oocyt recombin express nachr nachr subtyp antagonis adalin time depend voltag depend non competit manner lowest ic rat locust neuron nachr hold potenti mv data impli adalin act open channel blocker nachr
|
D011978;D001517;D000470
|
T123;T121;T116;T192;T109;T131;T204
|
36,296,665
|
push pull effect terpyridin substitut triphenylamin motiv impact viscos polar proton molecular optic properti introduct electron donat triphenylamin motiv terpyridin terpi moieti cornerston molecular unit coordin chemistri open new way ration design photophys properti organ inorgan compound push pull compound di tert butylphenyl amin phenyl terpyridin tbutpaterpi thorough investig use steadi state time resolv spectroscopi densiti function theori dft calcul result demonstr solvent paramet enorm influenc optic properti molecul act knob extern control photophys intramolecular charg transfer ict process introduc remark solvent polar effect emiss spectra without affect lowest absorpt band confirm dft simul includ solvat effect calcul ascrib lowest absorpt transit two singlet ict excit state sever order magnitud higher oscil strength dark state temperatur viscos investig suggest exist two emit excit state differ structur conform phosphoresc emiss band observ k assign local terpi state final proton studi show tbutpaterpi undergo revers process make promis probe ph level context acid determin
|
D004583;D000588
|
T081;T196;T109
|
36,296,663
|
prepar chiral enantioenrich dens substitut cyclopropyl azol amin ether via formal n substitut bromocylopropan enantiomer enrich cyclopropyl ether amin cyclopropylazol deriv possess three stereogen carbon atom small cycl obtain via diastereoselect formal nucleophil substitut chiral non racem bromocyclopropan key featur methodolog util chiral center cyclopropen intermedi govern configur two adjac stereocent success instal via additionepimer sequenc
|
D000588;D018681
|
T121;T109
|
36,296,661
|
synthesi trifluoromethyl monoterpen amino alcohol first time monoterpen trifluoromethyl hydroxi benzyl oxim synthes yield nucleophil addit ruppert prakash reagent tmscf correspond keto benzyl oxim base nopinon verbanon camphoroquinon trifluoromethyl determin entir proceed chemo stereoselect co rather cn bond trifluoromethyl benzyl oxim reduc correspond trifluoromethyl amino alcohol yield structur configur compound obtain establish
|
D000605;D039821
|
T121;T109
|
36,296,660
|
chemic composit vitro antioxid activ sida rhombifolia l volatil organ compound current studi phytochem constitu volatil organ compound voc obtain sida rhombifolia l identifi gc fid gc ms analysi total volatil organ compound identifi major compon rhombifolia voc identifi palmit acid phytol trimethyl pentadecanon oleic acid pentyl furan linol acid voc rich fatti acid olefin aldehyd keton enol aldehyd keten antioxid capac rhombifolia voc determin diphenyl picryl hydrazyl hydrat dpph azinobi ethylbenzothiazolin sulfon acid diammonium salt abt ferric reducingantioxid power frap method butyl hydroxytoluen bht trolox standard voc show dose depend antioxid activ ic inhibitori concentr valu mgml dpph abt assay respect frap antioxid capac mmg result show voc distil rhombifolia moder antioxid properti util natur botan supplement antioxid
|
D000975;D055549
|
T123;T121;T109;T039;T044
|
36,296,659
|
recent advanc copper base organ complex nanoparticl tumor theranost treatment drug resist form cancer requir consider hallmark featur abnorm cell death mechan mutat drug respond molecular pathway malign cell differ normal counterpart numer aspect includ copper metabol intracellular copper level elev various cancer type phenomenon could employ develop novel oncotherapeut approach copper maintain cell oxid level regul protein activ metabol involv inflamm various copper base compound nanoparticl metal base organ complex show specif activ cancer cell accord preclin studi herein summar major principl copper metabol cancer cell potenti cancer theranost
|
D053758;D009369;D056831
|
T104;T191;T073
|
36,296,658
|
evalu intracellular signal activ opioid receptor agonist nalfurafin analog focus select g protein arrestin mediat pathway opioid receptor or classifi three type opioid analges main mediat activ howev use sometim restrict unfavor effect select agonist nalfurafin initi develop analges indic chang narrow safeti margin activ or main induc two intracellular signal pathway g protein mediat pathway arrestin mediat pathway recent expect analges select activ pathway increas howev structur properti requir select nalfurafin still unknown therefor evalu partial structur nalfurafin necessari select two pathway assay properti nalfurafin six nalfurafin analog syk use cell stabli express or syk activ or concentr depend manner higher ec valu nalfurafin upon bias factor assess syk possess hydroxi group show higher select g protein mediat signal activ nalfurafin suggest direct hydroxi group may affect arrestin mediat pathway conclus nalfurafin analog hydroxi group syk could consid g protein bias agonist
|
D017473;D000701
|
T121;T116;T109;T192;T131
|
36,296,657
|
enhanc degrad antibiot peroxydisulf catalysi cuo cnt simultan oxid electron transfer regim nonrad process peroxydisulf pds oxid system promis method antibiot remov water studi cuo cnt success synthes facil approach catalyz pds remov effici antibiot sulfamethoxazol smx min stoichiometr effici smxpds differ degrad effici common organ contamin reveal select oxid survey system process oxid electron transfer regim exhibit chemic quench test electron paramagnet reson epr determin uv vis spectrophotomet x ray photoelectron spectroscopi xps detect cyclic voltammetri cv measur sustain catalysi promot circul surfac electron rich center cu ii cu iii dissolv oxygen metast cu iii intermedi contribut generat still portion smx remov mild activ pds moreov influenc factor ph dosag water matrix examin suppress accept common anion real water distinguish radic process uniqu intermedi product ascertain via theoret calcul liquid chromatographi mass spectrometri lc ms detect furthermor cuo cnt show satisfactori activ abil cycl experi overal studi develop cnt support cuo unveil mechan catalysi evalu applic potenti nonrad process
|
D004583;D000900
|
T081;T121;T196;T195
|
36,296,656
|
person treatment infantil ascend hereditari spastic paralysi base silico strategi infantil onset hereditari spastic paralysi iahsp rare neurolog diseas diagnos less children worldwid transmit recess pattern origin mutat al gene encod protein alsin involv differenti mainten upper motoneuron exact pathogen mechan iahsp neurodevelopment diseas still larg unknown howev previous studi reveal cytosol compart alsin present activ tetram first assembl dimer pair c termin vps domain key interact site alsin dimer present innov drug discoveri strategi identifi drug candid potenti treat patient harbor two al mutat one truncat lysin consid substitut arginin tryptophan rw c terminus vps protein model approach obtain rw mutant model character impact mutat stabil flexibl vps furthermor show arginin essenti alsin homo dimer mutat tryptophan lead abnorm dimer pattern disrupt format activ tetram final perform virtual screen individu alreadi therapi approv compound mk abl mask mutant residu establish alsin tetram hela cell mk approv compassion use
|
D014364;D008239
|
T121;T123;T116;T109;T046
|
36,296,655
|
pharmacotherapeut applic chemistri chalcon deriv chalcon well examin extant literatur demonstr antibacteri antifung anti inflammatori anticanc properti detail evalu purport health benefit chalcon deriv includ molecular mechan pharmacolog activ explor therefor review aim describ main characterist chalcon deriv includ method synthesi pharmacotherapeut applic molecular mechan presenc reactiv unsatur system chalcon ring show differ potenti pharmacolog properti includ inhibitori activ enzym anticanc anti inflammatori antibacteri antifung antimalari antiprotozo anti filari activ chang structur ad substitu group aromat ring increas potenc reduc toxic broaden pharmacolog action report also summar potenti health benefit chalcon deriv particular antimicrobi activ found sever chalcon compound inhibit divers target antibiot resist develop pathway therefor overcom resist bacteria becom suscept antibacteri compound chalcon compound activ convent antibiot like vancomycin tetracyclin anoth note seri pyran fuse chalcon trichalcon block nf b signal complement system implic inflamm sever compound demonstr potent lipoxygenas inhibit nsaid indomethacin report integr discuss domain medicin chemistri organ synthesi divers pharmacolog applic particular develop new anti infect agent could use refer pharmaceut scientist
|
D002599;D047188;D000962;D000890
|
T121;T109
|
36,296,654
|
self organ porphyrin pom dyad nonplanar diacid oxoanion low dimension h bond network coordin spatial arrang electroact partner crucial design molecular electron photon porphyrin ubiquit reaction center natur synthet porphyrin crystallograph solid state often coerc monolith stack inhibit reactiv use principl self organ exploit charg balanc principl manipul nonplanar porphyrin one two dimension hydrogen bond polym polyoxometal pom bifunct counter anion serv linker herein report crystal structur systemat studi interact dodecasubstitut porphyrin acid nonstandard counterion well induc conform porphyrin core show hydrogen bond chelat viabl method organ electroact center filament monolay surfac deposit ultrathin devic
|
D011166
|
T123;T109
|
36,296,653
|
wast cook oil modifi epoxi asphalt rubber binder improv compat extend allow construct time applic crumb rubber end life tire wast cook oil wco road pavement signific import econom environment viewpoint howev incorpor crumb rubber great shorten allow construct time epoxi asphalt binder due high viscos epoxi asphalt rubber ear binder poor compat crumb rubber asphalt binder lower viscos asphalt rubber extend allow construct time improv compat ear binder wast cook oil wco introduc effect wco viscos time behavior thermal stabil dynam modulus glass transit crosslink densiti damp abil compat mechan properti phase separ wco modifi ear binder investig use brookfield viscomet thermogravimetr analysi dynam mechan analysi univers test machin laser confoc microscopi test result demonstr incorpor wco declin viscos extend allow construct time unmodifi ear binder inclus wco improv compat asphalt crumb rubber damp abil elong break unmodifi ear binder presenc wco margin effect thermal stabil unmodifi ear binder confoc microscopi observ reveal asphalt rubber particl aggreg epoxi phase unmodifi ear binder inclus wco co continu asphalt rubber particl becam spheric
|
D006838;D003296
|
T056;T109
|
36,296,652
|
bimetal au ag nanoparticl advanc nanotechnolog tackl antimicrobi resist date antimicrobi agent avail market absolut control grow threat bacteri strain increas product capac antibiot grow antibacteri resist bacteria major affect varieti busi public health bimetal nanoparticl nps two separ metal found stronger antibacteri potenti monometal version enhanc antibacteri effici bimetal nanoparticl due synergist effect particip monometal counterpart distinguish bacteria mammal exist divers metal transport system metalloprotein necessari use bimetal au ag nps like metal nps due low toxic toward human cell bimetal nps particular gold silver nps might prove effect weapon arsenal beat emerg drug resist bacteria cellular mechan bimetal nanoparticl antibacteri activ consist cell membran degrad disturb homeostasi oxid stress product reactiv oxygen speci synthesi bimetal nanoparticl perform bottom top strategi bottom techniqu general includ sol gel chemic vapor deposit green synthesi co precipit method wherea top techniqu includ laser ablat method review highlight key prospect cellular mechan synthesi process antibacteri capabl wide rang bacteria addit also discuss role au ag nps treatment multidrug resist bacteri infect wound heal
|
D053768;D008667
|
T123;T116;T073
|
36,296,651
|
benzophenon rhamnosid chromon hypericum seniawinii maxim two new benzophenon glycosid hypersen b along four known compound dihydroxi methylpropyl chromon dihydroxi isopropylchromon urachromon b bisapigenin isol hypericum seniawinii structur new compound elucid accord comprehens spectroscop data analys absolut configur determin electron circular dichroism ecd calcul isol compound evalu neuroprotect effect use corticosteron induc pc cell injuri addit compound evalu anti inflammatori activ lipopolysaccharid induc raw cell compound biflavonoid signific inhibit product nitric oxid ic valu
|
D020902;D018696;D044946
|
T121;T169;T002;T109
|
36,296,650
|
new trend qualiti control enantiomer drug qualiti design compliant develop chiral capillari electrophoresi method capillari electrophoresi ce potent method analyz chiral substanc common use enantiosepar chiral puriti control pharmaceut differ matric adopt qualiti design qbd concept analyt method develop optim valid widespread trend observ various analyt approach includ chiral ce applic analyt qbd aqbd lead develop analyt method base sound scienc combin risk manag well understood process clarifi influenc method paramet analyt output design experi doe method employ chemometr tool essenti part qbd base method develop allow simultan evalu experiment paramet well interact intern council harmon ich releas two draft guidelin ich q ich q r intend encourag robust analyt procedur ich q guidelin intend harmon scientif approach analyt procedur develop q r document cover valid principl use analyt procedur includ recent applic requir multivari statist analys aim review provid overview new prospect chiral ce method develop appli enantiomer puriti control pharmaceut use aqbd principl review also provid overview recent research applic ce method chiral drug impur profil
|
D019075;D004340
|
T068;T059
|
36,296,649
|
investig volatil iridoid terpen nepeta cataria l catnip genotyp catnip nepeta cataria l scientif interest larg due product nepetalacton volatil iridoid terpen strong arthropod repel activ howev plant also produc bioactiv volatil iridoid nepetal acid na nepetalactam nt dihydronepetalacton dhnl studi extens germplasm studi plant produc compound scarc present studi evalu chemic divers catnip genotyp focus na nt dhnl total genotyp harvest differ time two year ethanol extract plant screen iridoid ultra high perform liquid chromatographytripl quadrupol mass spectrometri cr cr genotyp highest valu biomass yield cultivar cr highest valu accumul na genotyp uk highest valu accumul nt yield cr highest valu accumul dhnl overal patent cultivar elit select perform better less studi genotyp harvest time influenc accumul secondari metabolit differenti genotyp first germplasm studi focus iridoid compound yet studi necessari genotyp character essenti breed standard product industri
|
D027521;D009822
|
T002;T109
|
36,296,648
|
green extract forsythosid phillyrin phillygenol forsythia suspensa leav use cyclodextrin assist method studi green process cyclodextrin cd assist extract activ ingredi forsythia suspensa leav develop first optim process extract follow ratio forsythia suspensa leav cd solid liquid ratio temperatur c ph yield forsythosid phillyrin phillygenol respect structur characterist cd assist extract forsythia suspensa leav fse cd analyz use powder x ray diffract pxrd fourier transform infrar spectroscopi ft ir differenti scan calorimetri dsc scan electron microscopi sem molecular dock demonstr natur activ product forsythia suspensa leav signific interact cd addit loss forsythosid aqueous fse cd c compar forsythia suspensa leaf extract fse decreas addit aqueous solubl fse cd signific increas gl ec scaveng dpph abt radic decreas ugml ugml respect result show cd assist extract process would promis technolog bioactiv compound extract plant
|
D031657;D003505;D047392
|
T130;T002;T109
|
36,296,647
|
cinnamomum verum j presl bark contain high content nicotinamid mononucleotid global popul age intervent strategi anti age prevent age relat diseas becom topic activ explor today nicotinamid adenin dinucleotid nad import molecul metabol process content tissu cell decreas age supplement nicotinamid mononucleotid nmn import intermedi precursor nad increas nad level safeti demonstr rodent human studi howev high content nmn natur plant fulli explor herbal medicin drug develop identifi leaf cinnamomum verum j presl c verum highest nmn content among plant extract librari pel food experi use ultra perform liquid chromatographi tandem mass spectrometri uplc msms valid result extract quantit analysi bark leaf root stem fresh c verum conduct result reveal bark highest nmn content c verum mg g studi shed light prospect develop natur plant context nmn drug anti age prevent age relat diseas futur focus develop applic c verum pharmaceut formul
|
D009537;D009243
|
T123;T121;T114
|
36,296,646
|
import hormon regul lipid metabol wide varieti kind lipid complex structur determin divers complex function basic characterist water insolubl lipid molecul independ genet inform compos gene protein determin particular lipid human bodi water basic environ gene protein genet system review summar current landscap hormon regul lipid metabol well studi pik akt pathway insulin affect fat synthesi control activ product various transcript factor new mechan thyroid hormon regul discuss receptor may mediat differ procedur effect thyroid hormon mitochondria provid new insight hormon regul lipid metabol physiolog concentr adrenalin induc express extrapituitari prolactin adipos tissu macrophag promot fat weight loss manipul hormon action potenti offer new therapeut horizon global burden obes associ complic morbid mortal
|
D050356;D011388
|
T125;T121;T116;T044
|
36,296,645
|
bioassay guid isol iridoid glucosid stenaria nigrican bite deterr aed aegypti diptera culicida repel assess import fire ant hymenoptera formicida natur product screen program screen natur product repel toxic insect vector methanol extract aerial part stenaria nigrican lam publish chemistri test repel mosquito import hybrid fire ant methanol extract show bite deterr similar deet n n diethyl methylbenzamid aed aegypti l base activ crude extract fraction chloroform ethyl acet methanol subfract activ methanol subfract fraction subfract fraction test bite deterr ae aegypti activ subfract character identifi compound respons activ four undescrib iridoid glucosid three previous report compound isol activ subfract test bite deterr activ base bdi valu compound bite deterr similar deet show potenti use repel mosquito vitro dig bioassay none compound show repel hybrid import fire ant dose gg first report bite deterr repel nigrican extract pure compound iridoid glucosid mosquito import fire ant studi conduct explor repel potenti compound differ formul field condit
|
D000330;D009033;D001000;D007302;D019666;D001688
|
T121;T123;T131;T204;T002
|
36,296,644
|
redox reaction biolog activ molecul upon cold atmospher pressur plasma treatment aqueous solut cold atmospher pressur plasma capp wide use medicin treatment diseas disinfect bio tissu due antibacteri antivir antifung properti agricultur capp acceler imbibit germin seed signific increas plant product plasma also use fix molecular nitrogen capp produc reactiv oxygen nitrogen speci ron plasma treatment bio tissu lead numer side effect lipid peroxid genotox problem dna damag mechan occur side effect treat various organ cold plasma unknown sinc ron uv vis light multicompon biolog tissu simultan involv heterogen environ found capp induc vitro oxid common water solubl redox compound live cell nadh nadph vitamin c interfac air capp water capp capabl reduc nad benzoquinon despit presenc free electron capp prolong plasma treatment aqueous solut vitamin c hydroquinon benzoquinon respect lead decomposit studi mechan plasma induc process help prevent side effect medicin agricultur food disinfect
|
D058626
|
T104
|
36,296,643
|
bio comput evalu compound bacopa monnieri potenti treatment schizophrenia schizophrenia horribl mental disord character distort percept realiti investig identifi singl etiolog schizophrenia multipl hypothes base various aspect diseas specif treatment schizophrenia henc tri investig updat inform store genet databas relat gene could respons schizophrenia relat neuron disord implement combin comput methodolog protein protein interact analysi led system biolog approach silico dock analysi perform explor bind pattern bacopa monnieri natur compound interact stxbp best identifi compound cid base kcalmol bind energi select complex dynam evalu mds method output reveal stxbp cid complex show lowest rmsd valu ie nm henc identifi compound could use develop treat neuron disord vivoin vitro test
|
D034681;D012559
|
T002;T048
|
36,296,642
|
comparison effect cold plasma convent preserv method red wine qualiti use chemometr analysi studi effect cold plasma cp physicochem biolog properti red wine investig comparison effect convent preserv method combin method addit effect storag time applic analyz method evalu studi examin effect differ preserv method ph color phenol content antioxid activ microbiolog puriti red wine chemometr analysi use discov relationship preserv method use wine qualiti wine sampl test reduct phenol compound decreas antioxid activ note storag effect mildest preserv method addit potassium metabisulphit mixtur helium nitrogen use work gas posit note cp treatment affect color wine way percept consum e hen min addit lowest growth microorgan detect cp treat sampl indic potenti cold plasma altern method use potassium metabisulfit wine product may contribut wider use alcohol industri futur
|
D014920;D058626
|
T168;T104
|
36,296,641
|
electron spin reson dosimetri studi irradi sulfit salt studi new materi radiat dosimetri import improv present state art help case accid retrospect dosimetri sulfit compound contain sulfur ion wide use food industri due signific applic compound sulfit interest candid accident dosimetri fortuit radiat detector presenc anion enabl detect electron spin reson esr spectroscopi dose respons behavior signal stabil spectral featur investig sodium sulfit sodium bisulfit sodium metabisulfit potassium metabisulfit crystallin form esr spectrum salt present stabil proport respons dose present potenti dosimetri applic
|
D012492;D013447
|
T104;T197
|
36,296,640
|
metal free synthesi carbamoyl chroman one via cascad radic annul allyloxi arylaldehyd oxam acid effici straightforward approach synthesi carbamoyl chroman one well develop reaction trigger generat carbamoyl radic oxam acid metal free condit subsequ undergo decarboxyl radic cascad cyclize allyloxi arylaldehyd afford various amid contain chroman one scaffold high function group toler broad substrat scope
|
D010072;D002839
|
T116;T109
|
36,296,639
|
antibacteri porous system base polylactid load amikacin three porous matric base poli lactic acid propos herein control releas amikacin materi fabric method spray surfac liquid descript given possibl employ modifi silica nanocarri prolong releas amikacin addit use chitosan improv properti materi eg stabil sorption capac depend actual composit materi exhibit vari efficaci drug load follow gmg matric w v chitosan gmg w v sio amikacin modifi nanoparticl gmg matric without function addit vitro studi confirm extend releas drug amikacin day carri accord mathemat kosmyer pepa model materi test matric also evalu effect inhibit growth bacteria staphylococcus aureus escherichia coli klebsiella pneumonia pseudomona aeruginosa concurr research conduct transderm absorpt morpholog element composit thermogravimetr properti releas drug
|
D000583;D048271
|
T121;T195;T109
|
36,296,638
|
engin rhdl nanoparticl suitabl platform theranost applic reconstitut high densiti lipoprotein rhdls transport specif releas drug imag agent mediat scaveng receptor type b sr b present wide varieti tumor cell provid conveni platform develop theranost system usual phospholipid apo lipoprotein particl surfac motif use conjug molecul multifunct purpos rhdl nanoparticl cholesterol less address region bind molecul function group rhdl surfac maxim efficaci improv radiolabel rhdl theranost system synthes compound bifunct agent coval link cholesterol strategi mean radionuclid bound surfac therapeut agent encapsul lipophil core research hynic ch cholesterol dota benzen p sc nh ch nh cholesterol deriv synthes prepar nanoparticl nps hynic rhdl dota rhdl subsequ link radionuclid spectpet imag target radiotherapi hynic use complex tc dota label molecul ga lu tb ac cu among other vitro studi show nps hynic rhdl dota rhdl maintain specif recognit sr b abil intern releas cytosol cancer cell molecul carri core biodistribut mice show similar behavior rhdl without surfac modif hynic rhdl dota rhdl exhibit differ biodistribut pattern due signific reduct lipophil modifi cholesterol molecul system demonstr characterist develop suitabl theranost platform person cancer treatment
|
D057285;D053758
|
T061;T091;T073
|
36,296,637
|
chemic composit antibacteri antioxid activ five citrus essenti oil increas concern use antimicrobi growth promot anim product prompt need explor use natur altern phytogen compound probiot citrus eo potenti use altern antibiot anim purpos research studi antibacteri antioxid activ five citrus eo grapefruit essenti oil geo sweet orang eo seo bergamot eo beo lemon eo leo activ compon limonen eo dleo chemic composit eo analyz gas chromatographi mass spectrometri gc ms antibacteri activ eo three bacteria escherichia coli salmonella lactobacillus acidophilus test measur minimum inhibitori concentr mic minim bactericid concentr mbc inhibit zone diamet izd antioxid activ eo evalu measur free radic scaveng activ dpph abt found activ compon five citrus eo main terpen content limonen highest antibacteri test show citrus eo select antibacteri activ leo best select antibacteri activ similar leo best scaveng abil dpph radic dleo best scaveng abil abt although main compound five citrus eo limonen select antibacteri antioxid activ might primarili attribut limonen compound combin action
|
D009822;D002957
|
T168;T002;T109
|
36,296,636
|
evalu effect genistein vitro chemoprevent agent colorect cancer strategi improv effici administ oral colorect cancer crc rank third term incid second term mortal preval worldwid relat chemotherapi treatment use drug fluorouracil fu howev use drug generat various toxic effect system level reason new therapeut strategi current sought use neoadjuv adjuv treatment recent research shown natur compound genistein chemotherapeut anticanc effect mechan action genistein molecular target human colon cell fulli elucid result report relat non malign cell line also unclear allow evid select compound may therefor work genistein evalu vitro cancer cell line sw sw non malign cell line hacat result obtain show genistein select sw sw cell line addit inhibit cell viabil antiprolif effect dose depend manner increas product reactiv oxygen speci ros also found suggest associ cell death process various mechan final encapsul strategi propos made possibl demonstr bacteri nanocellulos bnc capabl protect genistein acid condit gastric fluid also allow releas compound colon fluid would allow genistein act local mucosa colon first stage crc occur
|
D019833;D015179
|
T123;T121;T191;T109
|
36,296,635
|
cyclometal palladium ii complex approach first dinuclear bis iminophosphoran phosphan c n metallacycl treatment bis iminophosphoran phosphan ligand e li pdcl gave set novel diphosphan deriv complex bear two metallacycl ring one enclos pn doubl bond unpreced bis iminophosphoran phosphan c n palladacycl case ligand deriv bis diphenylphosphino methan singl doubl palladacycl complex obtain reaction bis diphenylphosphino ethan yield expect product diphosphan bond palladium atom rather novel coordin compound crystal structur c describ
|
D010165;D008697
|
T196;T109
|
36,296,634
|
ultrasensit simultan detect multipl rare modifi nucleosid promis biomark low put breast cancer dna sampl clinic multi dimension diagnosi earli cancer diagnosi essenti success treatment prognosi modifi nucleosid attract widespread attent promis group cancer biomark howev analyz modifi nucleosid extrem low abund great challeng especi analyz multipl modifi nucleosid differ abund simultan work ultrasensit quantif method base chemic label coupl lc msms analysi establish simultan quantif hmdc fdc hmdu fdu addit content mdc canon nucleosid could obtain time upon derivat detect sensit hmdc fdc hmdu fdu dramat enhanc sever hundr time establish method appli simultan detect nine nucleosid differ abund g genom dna breast tissu breast cancer patient dna consumpt less overal report quantif method therebi provid opportun monitor rare modifi nucleosid precious sampl biolog process could investig content hmdc hmdu fdu tumor tissu normal tissu adjac tumor signific chang indic three modifi nucleosid may play certain role format develop tumor potenti cancer biomark detect rate hmdc hmdu fdu alon biomark breast cancer sampl respect detect three cancer biomark simultan two three consist overal trend therefor simultan detect multipl cancer biomark clinic sampl great improv accuraci cancer diagnosi indic method great applic potenti clinic multidimension diagnosi
|
D009705;D001943
|
T121;T191;T114
|
36,296,633
|
anti hiv ermiasolid croton megalocarpus recent year elucid novel anti hiv bioactiv compound natur product gain import rapid research public also control clinic studi report three new anti hiv eudesman type sesquiterpen hydroxi methoxi eudesm en olid dihydroxi eudesm en olid hydroxi h eudesm en olid trivial name ermiasolid c isol bark croton megalocarpus hydroxi methoxi eudesm en olid show highest anti hiv activ inhibit viral replic ic gml hand hydroxi h eudesm en olid dihydroxi eudesm en olid inhibit viral replic ic gml ic gml respect molecular dock studi show propos mechan action lead result inhibit hiv proteas
|
D029802;D045787;D012717;D001688
|
T123;T121;T002;T109
|
36,296,631
|
clinic potenti himalayan herb bergenia ligulata evid base studi herbal product use tradit system medicin ethnic healer age treat various diseas current estim peopl worldwid use herbal tradit medicin various ailment part due easi access low cost lower side effect pose bergenia ligulata herb rang himalaya foothil includ north eastern state india tradit use remedi various diseas promin kidney stone medicin properti b ligulata attribut bergenin potent bioactiv compon apart bergenin compound avail b ligulata arbutin gallic acid protocatechu acid chlorogen acid syring acid catechin ferul acid afzelechin paashaanolacton caryophyllen cineol eudesmol stigmasterol sitosterol parasorb acid methyl buten ol phytol terpinen ol tannic acid isovalar acid avicularin quercetin reynoutrin sitoinosid review summar various medicin properti herb along provid deep insight bioactiv molecul potenti role amelior human ailment addit possibl mechan action herb anti urolithiat antioxid antipyret anti diabet anti inflammatori hepatoprotect properti discuss comprehens document help research better understand medicin use herb studi b ligulata lead discoveri new drug therapeut various ailment
|
D002392;D058633;D031995;D010946
|
T121;T039;T002;T109
|
36,296,630
|
format optim character antioxid activ auricularia amp nbsp auricula juda polysaccharid nanoparticl obtain via antisolv precipit auricularia auricula juda polysaccharid aap base nanoparticl nps prepar via anti solvent precipit approach studi respons surfac methodolog rsm design carri basi singl factor experi use averag size polydispers index pdi indic optim prepar condit determin includ aap concentr mgml ph anti solventsolv volum ratio averag particl size aap nps pdi electr characterist potenti found nm mv respect furthermor fourier transform infrar spectroscopi ftir use determin chemic structur aap nps observ intens aap nps wide spectral band cm signific stronger aap characterist peak carboxyl anion characterist band move shorter wavelength subsequ thermogravimetr analysi show antisolv precipit method improv thermal stabil aap scan electron microscopi sem x ray diffract xrd show morpholog aap nps uniform well distribut singl crystal structur remain unaffect process moreov dpph abt scaveng activ aap nps increas ic valu mgml mgml respect
|
D000975;D053758
|
T123;T121;T073;T039;T044
|
36,296,629
|
develop hpv genotyp detect platform base aggreg induc emiss aie flow hybrid technolog genet mutat caus life threaten diseas cancer sickl cell anemia gene detect thus import diseas risk predict earli diagnosi treatment apart genet defect gene detect techniqu also appli gene relat diseas high risk human health human papillomavirus hpv infect hpv infect strong link cervic cancer achiev high throughput hpv gene detect platform flow hybrid system appear one commerci diagnost techniqu purpos flow hybrid techniqu base vacuum guid flow dna fragment continu direct toward oligoprob immobil test membran howev convent colorimetr method signal read approach suffer problem low sensit contrari fluoresc approach allow sensit detect broad sens rang work fluoresc dye hcap possess aggreg induc emiss aie properti respons alkalin phosphatas develop appli flow hybrid platform achiev hpv genom diagnosi clinic sampl also automat membran reader construct base aie base diagnosi platform identifi diagnost result patient dna total concord rate clinic trial
|
D030361;D002583
|
T047;T191
|
36,296,628
|
potenti corchorus olitorius seed buccal film treatment recurr minor aphthous ulcer human volunt aphthous ulcer common disord among differ age group noxious pain incid aphthous ulcer recurr high may even last maximum day usual patient stand pain studi aim prepar buccoadhes fast dissolv film contain corchorus olitorius seed extract treat recurr minor aphthous ulcer rmau addit clinic experi human volunt excis wound model use assess vivo wound heal potenti corchorus olitorius l seed extract focus wound heal molecular target tgf tnf il addit metabolom profil use hr lcms crude extract corchorus olitorius seed explor moreov molecular dock experi perform elucid bind confirm isol compound three molecular target tnf il gsk addit vitro antioxid potenti c olitorius seed extract use h superoxid radic scaveng activ examin clinic experi human volunt reveal effici prepar c olitorius seed buccal fast dissolv film cobfdf reliev pain wound heal rmau moreov wound heal result reveal c olitorius seed extract enhanc wound closur rate p elev tgf level signific downregul tnf il comparison mebo treat group phenotyp result support biochem histopatholog find metabolom profil use hr lcms crude extract corchorus olitorius seed yield total compound belong divers chemic class final studi highlight potenti c olitorius seed extract wound repair uncov probabl mechan action use silico analysi
|
D032381;D013281
|
T047;T002
|
36,296,627
|
griseofulvin updat overview old current knowledg griseofulvin antifung polyketid metabolit produc main ascomycet sinc commerci introduc griseofulvin use treat dermatophyt infect fungistat gain increas interest multifunct applic last decad due potenti disrupt mitosi cell divis human cancer cell arrest hepat c virus replic addit inhibitori effect other found griseofulvin may enhanc ace function contribut vascular vasodil improv capillari blood flow furthermor molecular dock analysi reveal griseofulvin deriv good bind potenti sar cov main proteas rna depend rna polymeras rdrp spike protein receptor bind domain rbd suggest inhibitori effect sar cov entri viral replic find impli repurpos potenti fda approv drug griseofulvin design develop novel therapeut intervent review summar avail inform discoveri recent progress grow field addit explor possibl mechan lead rare hepat induc griseofulvin found griseofulvin metabolit includ desmethylgriseofulvin dmg desmethylgriseofulvin dmg favor interact cytokeratin intermedi filament protein k k rang kcal mol therefor could respons liver injuri mallori bodi mb format hepatocyt human mous rat treat griseofulvin moreov stronger bind griseofulvin k rodent human may explain observ differ sever hepat rodent human
|
D000086382;D061065
|
T121;T047;T067;T109
|
36,296,626
|
compar studi larvicid activ spinel co nanorod entomopathogen metarhizium brunneum conidia culex pipien herein report synthesi spinel cobalt oxid nanorod co nrs modifi co precipit approach examin larvicid activ culex pipien structur morpholog prepar co nrs emphas use x ray diffract xrd raman spectroscopi energi dispers x ray spectroscopi edax scan electron microscopi sem transmiss electron microscopi tem found co nanostructur face center spinel cubic crystal structur mean crystallit size nm nanostructur rod like shape mean diamet nm averag length nm tga measur reveal high stabil form spinel cubic structur c optic behavior indic direct transit electron optic band gap rang ev uniqu chemic physic properti co nrs enabl employ strong agent kill c pipien comparison studi employ prepar co entomopathogen fungus metarhizium brunneum control agent c pipien larva result reveal prepar nanorod higher mortal c pipien larva compar well known brunneum
|
D003465;D052981;D043942
|
T004;T073;T204
|
36,296,625
|
character optim salep mucilag bionanocomposit film contain allium jesdianum boiss nanoliposom antibacteri food packag util research aim character compar properti nanoliposom nl p load salep mucilag base bionanocomposit film contain free encapsul allium jesdianum boiss essenti oil eo mean size nanoliposom contain allium jesdianum boiss essenti oil nl p eo around nm zeta potenti valu mv entrap effect base evalu nl p prepar use thin film hydrat ultrason approach morpholog studi corrobor find zetas investig nl p eo ad salep mucilag base bionanocomposit film tensil strength ts water solubl ws water content wc water vapor permeabl wvp found decreas contrast contact angl oxygen permeabl p elong break eab increas scan electron microscopi sem atom forc microscopi afm imag indic salep mucilag base bionanocomposit film ad nl p eo disord inner network cross section rough structur surfac compar control film final increas antibacteri activ decreas eo releas rate observ salep mucilag base bionanocomposit film incorpor nl p eo result indic nl p eo innov sustain releas system potenti use develop antibacteri food packag base salep mucilag shelf life extens perish food product
|
D000490;D009822
|
T002;T109
|
36,296,624
|
influenc activ site flexibl effici substrat activ activ site bi zinc metallo lactamas influenc activ site flexibl effici catalyt reaction studi take two member metallo lactamas l ndm substrat imipenem activ site protein cover l loop differ amino acid composit affect rigid flexibl loop ndm bring addit flexibl activ site es complex pronounc wider distribut key interatom distanc distanc nucleophil attack coordin bond length coval bond length substrat substrat activ quantifi fukui electrophil index carbonyl carbon atom substrat also sensit activ site flexibl tighter rigid l enzym substrat complex substrat activ effici ndm contain system one third state activ extent fraction demonstr lower substrat activ effici substrat activ rigid es complex influenc follow chemic reaction rigid l contain system reaction barrier first step reaction lower first intermedi stabil compar ndm contain system
|
D001618;D015032
|
T123;T121;T116;T196;T126
|
36,296,622
|
evalu dna damag effect induc differ tan agent use process natur leather pilot studi hepg cell line long time product process cowhid base use chrome tan howev grow problem chromium wast negat impact human health environ prompt search environment friend process veget tan aldehyd tan present studi investig dna damag effect induc hepg cell h exposur leather sampl cut cm rectangl process differ tan agent main object determin tan procedur result highest dna instabl extent treatment induc dna damag determin use alkalin comet assay tan process use leather process caus primari dna damag hepg cell compar untreat cell effect measur expos cell indic leach potenti genotox chemic surfac variabl highest veget tan follow synthet tan chrome tan result could due complex composit veget synthet tan agent despit limit preliminari result could use gain general insight genotox potenti process use process natur leather plan futur experi specif cell tissu model
|
D013633;D007220
|
T131;T057
|
36,296,620
|
amelior effect imperatorin dermatophagoid pteronyssinus induc allerg asthma suppress th respons mice imperatorin furanocoumarin deriv effect ingredi sever chines medicin herb favor expector analges anti inflammatori effect studi investig whether imperatorin protect effect dermatophagoid pteronyssinus der p induc asthma mice lung bronchial tissu histopatholog examin hematoxylin eosin stain concentr immunoglobin e ige igg igga serum helper th two cytokin eosinophil activ chemokin bronchoalveolar lavag fluid balf detect use enzym immunoassay histolog examin reveal imperatorin reduc inflammatori cell infiltr mucus hypersecret endotheli cell hyperplasia examin also indic imperatorin could reduc inflammatori cell count balf well ige igg express serum igga express signific increas imperatorin reduc product interleukin il il il th promot product interferon il th increas product il bronchoalveolar lavag fluid find suggest imperatorin consider anti inflammatori effect der p induc allerg asthma mice
|
D001249;D011564
|
T121;T047;T109
|
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