PMID
int64 35.7M
36.4M
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36,344,062
|
editori commentari two fixat point better medial patellofemor ligament reconstruct minim complic bone tunnel avoid medial patellofemor ligament mpfl reconstruct gain popular past year studi show clear advantag techniqu mpfl repair medial imbric treatment patellar instabl debat continu type fixat patella tunnel versus sutur anchor well number fixat point fact senior patellofemor surgeon opt away patellar boni fixat altogeth avoid complic associ patellar fixat fractur penetr articular cartilag practic prefer use sutur sutur anchor patellar fixat minim risk fractur signific cartilag damag compar tunnel drill placement larger sutur anchor graft choic mpfl reconstruct shown relat unimport reason typic choos gracili allograft avoid graft site morbid hamstr weak
|
D057071;D007593;D050723;D031222
|
T033;T037;T030
|
36,344,061
|
editori commentari gait symmetri anterior cruciat ligament reconstruct improv use function rehabilit brace resist knee motion effort rehabilit journey solv sever known function clinic problem anterior cruciat ligament reconstruct direct toward implement effect recoveri strategi start day surgeri resist train reliabl approach restor general knee function earli postop stage may difficult appli proper load strategi obtain tangibl improv owe surgeri relat impair accord appli continu light resist function task gait may help address issu brace model provid resist knee motion recent develop shown help restor proper walk pattern term moment rang motion symmetri therefor adopt brace model may regard suitabl option consid boost achiev rehabilit mileston therefor general improv rehabilit qualiti
|
D000070598;D059549
|
T061;T037
|
36,344,060
|
editori commentari import capsular closur follow hip arthroscopi leav trace outdoorsman rambl decad long paradigm shift evid base enorm increas preval hip arthroscop procedur hip capsular closur follow arthroscopi rare procedur perform major surgic case result improv surgeon experi refin surgic technolog techniqu explos research regard stabil hip joint view inher stabl becom clear meticul capsular manag closur maintain joint stabil treatment andor prevent micro instabl recent research show hip capsular closur improv outcom return sport rate highest demand athlet hip arthroscopi close capsul
|
D001182;D057925
|
T060;T046;T061
|
36,344,059
|
editori commentari routin preoper magnet reson imag hip arthroscopi wast health care dollar delay surgic intervent decis make discret health care provid mandat health care insur make accur preoper diagnosi critic optim outcom hip arthroscopi detail histori thorough physic examin imag studi diagnost inject must consid decis make process today health care climat imper obtain essenti indic preoper inform mind health care dollar magnet reson imag mri hip shown high sensit modal hip pelvi disord howev critic recogn acetabular labral tear hip patholog high preval asymptomat young adult popul certain situat mri obtain suspect arthrit symptom avascular necrosi synovi disord uncommon osseous tumor howev patient general present atyp symptom addit obtain mri delay surgic intervent shown lead inferior outcom prior studi mri imper patient present typic intermitt deep anterior later groin pain prolong sit twist pivot transit sit stand typic physic examin includ posit hip imping test fadir anterior imping test recreat patient present complaint appropri imag includ plain radiograph reveal adequ acetabular coverag signific dysplast acetabular overcoverag pincer type femoracetabular imping cam type femoracetabular imping well maintain joint space view includ fals profil radiograph evalu anterior joint space final diagnost inject invalu confirm hip joint proper sourc pain criteria met strong believ mri unlik alter surgic decis make process end treat clinician determin mri necessari base present symptom examin rather insur appli blanket requir preauthor physician autonomi would ultim lead effici cost effect patient care medicin art unjustifi handcuf artist without evid could result inferior result
|
D057925
|
T046
|
36,344,058
|
editori commentari racial econom inequ lead diminish access rotat cuff repair treat one review us state health care data pertain rotat cuff repair key differ relat patient race ethnic incom status eventu surgeri black race hispan ethnic medicaid insur associ lower rate rotat cuff repair asian race male gender worker compens insur associ greater rate consider covari make us awar specif dispar lead differ rotat cuff repair greater health care access general patient physician system factor critic reach better level understand potenti treatment need improv inclus equiti patient seek rotat cuff repair
|
D017006;D000070636
|
T033;T023;T037;T047
|
36,344,057
|
editori commentari shoulder hill sach lesion remplissag medial anchor posit must optim achiev stabil yet minim extern rotat loss track hill sach lesion hsl signific risk factor recurr shoulder instabl arthroscop bankart repair bankart repair combin remplissag better restor shoulder stabil versus isol bankart repair treat combin bankart lesion track hsl howev remplissag may nonanatom associ limit shoulder extern rotat er especi arm shoulder abduct posit excess medial placement remplissag anchor associ postop er loss increas glenohumer cartilag degener use medial anchor result lower articular forc thus patient shoulder instabl recommend use remplissag anchor bankart lesion plus track hsl anchor place medial achiev stabil medial result postop stiff signific er loss
|
D000070896;D007593;D012783;D012785
|
T030;T033;T023;T037;T047
|
36,344,056
|
editori commentari classic arthroscop anterolater acromioplasti translat clinic meaning differ later acromi overcoverag despit time honor tradit classic neer acromioplasti come increas scrutini recent literatur particular perform absenc rotat cuff repair american medic associ current procedur terminolog committe transit acromioplasti procedur definit relat current procedur terminolog code procedur ad shoulder arthroscopi sever author sought investig true valu arthroscop subacromi decompress extrins sourc imping common indic acromioplasti includ bursal side tear promin type iii hook acromi morpholog calcifi coracoacromi ligament sever rotat cuff tendinopathi howev classic arthroscop acromioplasti may meaning address later outlet imping acromi overcoverag measur elev critic shoulder angl acromi index therebi lead persist abduct imping mechan abras case later acromi resect mm may preferenti consid decreas patholog critic shoulder angl reduc risk primari secondari rotat cuff tendon failur
|
D001182;D000070636
|
T061;T060;T033;T037;T047
|
36,344,055
|
dermal allograft augment rotat cuff tear larg massiv rotat cuff tear continu challeng shoulder surgeon given high percentag retear repair tear sever surgic technic advanc propos use graft xenograft synthet allograft augment repair grow last sever year attempt improv structur integr postop outcom patch augment dermal allograft common use show promis biomechan structur function outcom sever factor associ heal outcom includ age tear size fatti degener rotat cuff heal index use assess patient hamada grade elev retear risk potenti indic repair graft augment score point repres reason threshold addit dermal allograft due signific reduct heal rate compar patient score point point without augment repair biomechan studi demonstr greater maximum failur load compar standard repair heal rate rotat cuff repair use scaffold rang compar nonaug repair moreov use repair augment associ improv rang motion function score compar nonaug repair allograft show best visual analog scale pain score postop extern rotat result given favor heal rate function outcom low complic rate augment rotat cuff repair dermal allograft may suitabl option activ patient diminish chanc postop heal
|
D000070636
|
T033;T047;T037
|
36,344,053
|
earli treatment shoulder patholog necessari enough perform delay treatment shoulder instabl result bone loss requir complic surgeri turn result less optim outcom similar delay treatment repair rotat cuff tear result irrepar tear requir complic surgeri result less optim outcom delay treatment shoulder patholog problem solut includ educ research investig
|
D007593;D012785;D000070636
|
T030;T033;T023;T037;T047
|
36,344,052
|
aronia melanocarpa polysaccharid amelior liver fibrosi tgf mediat activ pikakt pathway modul gut microbiota purpos experi investig anti hepat fibrosi effect aronia melanocarpa polysaccharid amp taa induc liver fibrosi mice mechan well chang intestin flora vivo establish dose mgkg taa ip everi three day last eight week colchicin mgkg amp mgkg given intragastr administr ig day intraperiton inject taa amp treatment signific inhibit activ liver injuri marker alt ast serum histopatholog stain demonstr amp signific revers taa induc hepatocyt necrosi collagen deposit addit amp treatment block tgf smad pathway inhibit product ecm allevi liver fibrosi furthermor amp treatment enhanc phosphoryl pikakt decreas express downstream apoptosi relat protein liver thus effect allevi taa induc liver fibrosi addit rdna gene sequenc analysi show amp treatment help restor imbalanc ecosystem gut microb increas proport bacteroidet proteobacteria increas speci rich find clear show amp effect method treat liver fibrosi possibl improv gut microbiota
|
D000069196;D046936
|
T007;T002;T001
|
36,344,051
|
crocetin protect mitochondri damag induc uv irradi corneal epitheli cell line hce cell corneal epithelium locat outermost layer ocular surfac continu expos environment factor ultraviolet uv radiat sunlight uv irradi caus excess product reactiv oxygen speci ros cell result oxid damag membran bound organell mitochondria eventu lead cell death crocetin natur carotenoid found plant various biolog properti includ antioxid activ studi investig effect crocetin uv induc cell injuri corneal epithelium use vitro system human corneal epitheli cell transform hce cell line pretreat crocetin suppress reduct cell viabil induc uv exposur crocetin amelior decreas oxygen consumpt rate mitochondri fragment occur follow uv irradi crocetin inhibit ros product activ apoptosi pathway also preserv defect epitheli cell polar barrier function uv irradi hce cell reduct apic mucin express partial recov presenc crocetin take find togeth conclud crocetin protect effect uv irradi induc mitochondri injuri corneal epitheli cell
|
D014466;D004847
|
T070;T025
|
36,344,050
|
evalu counter histamin h receptor antagonist base effect murin model allergen induc nasal hyperrespons cell play essenti role develop allergen induc nasal hyperrespons nhr pathophysiolog respons allerg rhiniti effect histamin h receptor antagonist antihistamin murin nhr model investig intragastr epinastin fexofenadin loratadin administr suppress allergen induc immedi nasal respons nhr immun mice regardless allevi stimul induc th cytokin express loratadin desloratadin vitro allergen induc nhr nasal eosinophil infiltr th cell transfer mice unaffect loratadin vivo influenc cell mediat nhr exclud pharmacolog effect antihistamin
|
D006634;D017336
|
T121;T109
|
36,344,049
|
endoplasm reticulum stress regul high temperatur requir htra modul invas angiogenesi relat gene human trophoblast pathogenesi hypertens disord pregnanc hdp affect pregnant women still incomplet understood previous studi show endoplasm reticulum er stress influenc high temperatur requir serin peptidas htra express trophoblast invas howev involv er stress regul htra subtyp express pathophysiolog hdp character extravil trophoblast evt investig htrsvneo evt cell line treat er stress induc thapsigargin thap tunicamycin tuni treatment either thap tuni inhibit trophoblast invas reduc htra htra express alter htra htra express knockdown htra htra also inhibit trophoblast invas furthermor treatment either er stress induc htra silenc increas ratio solubl fms like tyrosin kinas placent growth factor sfltplgf marker hdp immunohistochem analysi reveal htra local evt endometri decidua placenta patient hdp result suggest factor caus er stress could result inhibit evt invas via htra
|
D014327;D040281
|
T018;T126;T116;T192
|
36,344,048
|
stathmin express alter antiprolif effect eribulin leiomyosarcoma cell uterin leiomyosarcoma aggress soft tissu tumor stathmin phosphoprotein modul microtubul dynam high express mani malign includ leiomyosarcoma microtubul depolymer agent eribulin recent approv treat malign soft tissu tumor although eribulin inhibit microtubul polymer littl known relationship eribulin treatment stathmin dynam studi explor role stathmin express action eribulin leiomyosarcoma cell eribulin induc phosphoryl stathmin reduc express subunit c protein phosphatas ppa leiomyosarcoma cell line ppa activ fti reduc level phosphoryl stathmin eribulin decreas stathmin protein level without affect stathmin mrna express furthermor stathmin knockdown attenu inhibitori effect eribulin cell viabil wherea stathmin overexpress enhanc anti prolif effect eribulin eribulin resist leiomyosarcoma cell line enhanc express class tubulin tubb multi drug resist protein mdr breast cancer resist protein bcrp decreas express stathmin taken togeth result suggest stathmin express modul pharmacolog efficaci eribulin uterin leiomyosarcoma cell
|
D050777;D007890
|
T123;T191;T116
|
36,344,047
|
target l type amino acid transport urolog malign current status futur perspect amino acid transport respons uptak amino acid critic cell prolifer l type amino acid transport play major role uptak essenti amino acid l type amino acid transport lat exert function properti form dimer fhc util cancer specif research diagnost imag therapeut agent malign tumor target lat progress various field hormon sensit prostat cancer regul l type amino acid transport lat androgen receptor ar identifi hand castrat resist prostat cancer negat regul lat ar determin furthermor fhc bind partner lat identifi specif downstream target androgen receptor splice variant ar v lat suggest contribut acquir castrat resist prostat cancer make lat complet differ therapeut target anti androgen taxan increas express lat also found renal bladder cancer suggest contribut acquir malign progress japan clinic trial lat inhibitor solid tumor progress clinic applic underway articl summar relationship lat urolog malign
|
D011471;D014571
|
T191
|
36,344,046
|
distinct effect orexin spontan evok synapt current rat nucleus tractus solitarius orexin produc hypothalam area orexin contain neuron distribut widespread area central nervous system orexin regul sever physiolog function arous food intak autonom control presenc orexin contain neuron termin orexin receptor confirm nucleus tractus solitarius nts receiv primari affer fiber peripher organ includ baroreceptor howev neuron effect orexin receptor ox r activ examin aim determin effect ox r activ excitatori synapt transmiss ox r activ increas frequenc spontan excitatori synapt current sepsc effect block prior applic l name contrast amplitud evok excitatori postsynapt current eepsc suppress ox r activ effect prevent cannabinoid receptor blocker pretreat l name altogeth result suggest ox r activ increas sepsc frequenc stimul product wherea inhibit eepsc releas endocannabinoid nts thus ox r activ distinct effect spontan evok excitatori synapt transmiss nts
|
D017552;D009435
|
T023;T043
|
36,344,045
|
deriv methoxetamin major methoxetamin metabolit potent block nmda receptor n methyl aspart receptor nmdar brain influenc psychoact drug chlorophenyl methylamino cyclohexan one ketamin analog ethylamino methoxyphenyl cyclohexanon methoxetamin recreat methoxetamin use caus sever toxic methoxetamin relat death also report therefor ban mani countri sinc methoxetamin deriv ethylamino tolyl cyclohexan one deoxymethoxetamin isopropylamino methoxyphenyl cyclohexan one methoxisopropamin sold onlin design drug howev deoxymethoxetamin methoxisopropamin act nmdar remain unknown studi first perform silico dock studi nmdar deoxymethoxetamin methoxisopropamin addit major methoxetamin metabolit amino methoxyphenyl cyclohexanon n desethyl methoxetamin ethylamino hydroxyphenyl cyclohexanon desmethyl methoxetamin dock studi suggest compound interact nmdar also determin half maxim inhibitori concentr ic methoxetamin relat compound nmdar use nmdar express cartwheel interneuron mice patch clamp record found ic methoxetamin deoxymethoxetamin methoxisopropamin n desethyl methoxetamin desmethyl methoxetamin nmdar respect result indic methoxetamin relat compound act potent nmdar blocker thus deoxymethoxetamin methoxisopropamin may caus damag block nmdar serious concern n desethyl methoxetamin desmethyl methoxetamin may caus sever advers effect methoxetamin metabol
|
D003512;D016194
|
T192;T116;T109
|
36,344,044
|
oroxylin phosphon deriv potenti enosno mediat relax attenu vasoconstrictor induc contract mous aorta oroxylin oroa flavonoid isol scutellaria baicalensi allevi cardiovascular dysfunct sever procedur synthes oroa develop show low product yield regioselect synthes oroa baicalin use one pot reaction increas overal yield also determin chemic properti mechan action synthes oroa oroa phosphat diethyl ester oroa oet vascular function induct vascular reactiv oroa oroa oet evalu use blood vessel myographi biochem analysi assess nitric oxid synthas mediat nitric oxid product mous aortic arteri oroa oroa oet induc sustain vasorelax part mediat endothelium isol normal arteri pre contract phenylephrin oroa oroa oet signific attenu vasoconstrictor induc contractil respons dilat effect block non select nitric oxid synthas inhibitor n omega nitro l arginin methyl ester tetraethylammonium h oxadiazolo quinoxalin one notabl preincub oroa oroa oet potenti acetylcholin induc relax endotheli nitric oxid product arteri endothelium oroa oroa oet protect cardiovascular dysfunct synthesi lead compound use improv yield oroa natur sourc also potenti regul vascular tone
|
D014662;D063065
|
T121;T131;T109
|
36,344,043
|
mechan canagliflozin induc vasodil resist mesenter arteri regul system blood pressur canagliflozin sodium glucos co transport sglt inhibitor report produc benefici cardiovascular effect includ reduct arteri contractil blood pressur howev whether canagliflozin could direct relax resist mesenter arteri under molecular mechan role regul system blood pressur remain unclear investig mechan regul small mesenter arteri contractil relev blood pressur regul pressur myographi data show canagliflozin applic rapid produc concentr depend vasodil mesenter arteri vasodil inhibit concurr inhibit smooth muscl cell voltag gate k channel k v dpo k v nm guangxitoxin k v linopirdin inhibit small intermedi larg conduct ca activ k channel sk ca apamin ik ca tram bk ca paxillin respect atp sensit k atp channel glibenclamid serca pump thapsigargin inhibit sglts phlorizin inhibit endotheli signal alter canagliflozin evok vasodil consist acut canagliflozin treatment mgkg bodi weight lower system blood pressur vivo overal data suggest canagliflozin stimul k v k v k v channel lead vasodil reduct system blood pressur
|
D014664;D000068896
|
T121;T109;T042
|
36,344,042
|
camostat mesil serin proteas inhibitor exert aquaret effect decreas urinari exosom aqp level serin proteas sps play physiolog role kidney previous report synthet sp inhibitor camostat mesil cm suppress sodium reabsorpt renal tubul show natriuret effect aldosteron infus rat aim explor novel physiolog role sps renal tubul understand mechan action sp inhibitor administ cm healthi rat spragu dawley rat classifi control cm subcutan sustain releas pellet group sacrif day cm signific increas urin volum approxim two fold urinari sodium osmolyt excret independ manner indic occurr free water excret serum vasopressin potassium calcium level osmol renal medulla affect free water reabsorpt renal tubul remain unchang cm administr cm decreas urinari exosom aqp excret suggest suppress aqp activ collect duct chang revers desmopressin infus water diuresi caus cm independ action prostasin tmprss result reveal associ sp inhibit free water handl demonstr cm administr exert diuret effect aqp downregul suggest sp inhibitor new class aquaret drug
|
D051399;D015842
|
T123;T121;T116
|
36,344,041
|
effect novel hepat b anti viral drug e cfcp renal organ acid transport current emerg drug resist import issu treatment hepat b virus hbv recent collabor group develop novel long act anti hbv drug e cfcp howev studi effect e cfcp kidney remain unclarifi use cell viabil uptak assay examin effect e cfcp function renal organ anion transport oat cytotox shown relat e cfcp renal oat either assay thus studi suggest e cfcp may novel excel candid drug treatment drug resist hbv
|
D006509;D027361
|
T123;T047;T116
|
36,344,033
|
concomit common iliac common femor arteri pseudoaneurysm reveal behcet diseas vascular involv one major caus mortal morbid behet diseas bd vasculo behet patient risk multipl vessel relat complic includ thrombos stenos occlus aneurysm report describ case young woman admit depart manag concomit common iliac common femor arteri pseudoaneurysm reveal behet diseas
|
D001528;D017541;D000783;D013927
|
T047;T046;T190
|
36,344,032
|
iliac arterioven fistula follow lumbar disc surgeri case report iliac arterioven av fistula lumbar disc surgeri uncommon entiti limit report case report describ year old man histori l l spinal discectomi complain congest heart failur symptom four year later comput tomographi angiographi cta reveal av fistula connect right common iliac arteri vein av closur later sutur common iliac arteri vein perform transperiton aorto iliac approach postop patient symptom orthopnea resolv follow six year unev
|
D008159;D001164
|
T023;T190
|
36,344,030
|
cerebr venous thrombosi associ infect endocard young patient cerebr venous thrombosi cvt rare complic infect endocard constitut diagnost therapeut emerg report case cerebr thrombophleb due infect endocard order discuss diagnosi manag situat patient year old man present sudden explos headach mening syndrom right hemiparesi right hypoesthesia cerebr ct angiographi show left parieto occipit intraventricular hematoma without classic aneurysm mycot aneurysm arterioven malform inject brain magnet reson imag found cvt front stop opacif left later branch superior sagitt sinus presenc fever poor oral status heart murmur justifi prescript transthorac echodoppl show veget healthi aortic valv patient put antibiot anticoagul favor evolut absenc usual risk factor cvt negat thrombophilia test inflammatori prothrombot state associ infect reinforc causal link infect endocard cvt format etiolog cvt variabl multipl requir comprehens assess infect endocard one rare etiolog cvt case anticoagul antibiot drug indic take account risk intracerebr bleed
|
D020767;D020246;D004696
|
T047;T046
|
36,344,029
|
specif manag lipodermatosclerosi sclerot hypoderm acut chronic phase lipodermatosclerosi sclerot hypoderm present complic venous insuffici particular post thrombot syndrom high risk progress leg ulcer howev also describ obes patient without venous insuffici even cours various system diseas includ scleroderma often affect middl age women usual bilater typic invert champagn bottl leg appear pathogen role venous hypertens explain compress band stock basi treatment acut phase may preced complic chronic form pain sever compress toler acut phase non steroid anti inflammatori drug intra lesion use triamcinolon capsaicin transderm patch indic neuropath pain propos chronic form treatment superfici venous insuffici andor incontin perfor vein document duplex ultrasound scan usual propos whenev possibl associ elast compress pentoxifyllin colchicin use without clear evid clinic efficaci final advanc clinic present appear sclerot gaiter associ ulcer surgic treatment excis cutan graft associ perfor vein ligat fasciotomi may discuss last resort treatment
|
D012594;D014689;D003872;D054070
|
T047
|
36,344,028
|
peri procedur complic follow endovascular revascular critic limb ischemia revascular procedur consid cornerston therapi patient critic limb ischemia cli multipl procedur often requir attain limb salvag aim present studi determin preval peri procedur complic endovascular procedur determin clinic biolog characterist patient associ risk peri procedur complic
|
D058729;D019161;D057510
|
T061;T121;T047;T109
|
36,344,027
|
aortic thrombosi dramat vascular complic covid diseas report clinic outcom covid relat acut aortic thrombosi aat
|
D000086382;D001018;D001157;D013927
|
T047;T046;T067
|
36,344,025
|
hemostat thrombot consider diagnosi manag childhood arteri ischem stroke narrat review although rare children arteri ischem stroke ai associ increas mortal neurolog morbid incid ai neonat period approxim year estim mortal signific proport children surviv ai experi life long neurolog deficit includ hemiparesi epilepsi cognit delay low incid childhood ai coupl atyp clinic present lack awar contribut delay diagnosi consequ earli initi treatment random clinic trial demonstr efficaci safeti reperfus therapi includ thrombolysi endovascular thrombectomi appropri select adult patient similar data children unavail consequ clinic decis surround reperfus therapi childhood ai either extrapol adult data base local experi etiolog childhood ai multifactori often occur set acquir congenit risk factor includ thrombophilia multipl studi investig associ thrombophilia incid childhood ai impact stroke recurr therefor durat intens antithrombot therapi less clear despit limit signific progress made last decad manag childhood ai progress attribut intern consortium select cohort feder fund clinic trial narrat review author systemat apprais literatur summar hemostat thrombot consider diagnosi manag childhood ai focus evid support reperfus therapi relev thrombophilia test durat drug choic secondari prophylaxi
|
D002545;D000083242;D006490;D020521;D019851
|
T121;T047;T046
|
36,344,024
|
perinat stroke fetus preterm term infant perinat stroke well defin heterogen group disord involv focal disrupt cerebr blood flow week gestat day postnat life focus lifetim risk stroke occur first week birth morbid perinat stroke high common caus hemiparet cerebr palsi result lifelong disabl becom appar throughout childhood perinat stroke classifi time diagnosi acut retrospect vessel involv arteri venous under caus hemorrhag ischem perinat stroke primarili report disord term infant howev preterm brain possess differ vulner predispos infant stroke injuri utero birth accur diagnosi perinat stroke syndrom import implic investig manag prognosi classif perinat stroke age present fetal preterm neonat term neonat infancychildhood summar review includ detail descript risk factor diagnosi treatment outcom controversi resourc famili support
|
D002547;D020521
|
T019;T047
|
36,344,022
|
neuroimag pediatr stroke pediatr stroke unfortun rare condit associ sever disabl mortal complex potenti clinic manifest result delay seek care diagnosi neuroimag play import role multidisciplinari respons pediatr stroke patient rapid develop adult endovascular thrombectomi creat new momentum health profession care pediatr stroke patient neuroimag critic make decis identifi appropri candid thrombectomi review articl review current neuroimag techniqu imag work strategi special consider pediatr stroke resourc limit area recommend substitut imag approach provid final promis new techniqu hypothesi driven research protocol discuss
|
D059906;D020521
|
T060;T047
|
36,344,021
|
close gap pediatr hemorrhag stroke systemat review pediatr hemorrhag stroke hs account larg proport childhood stroke top caus pediatr death morbid mortal lead signific socio econom psychosoci burden understand publish data recogn manag children hs conduct systemat review literatur present search pubm embas cinahl cochran librari databas limit english languag includ studi conduct usa terminolog use interchang hs includ intraparenchymalintracrani hemorrhag spontan ich cerebrovascular accid cva key assess inform prognosi manag includ clinic score glasgow coma scale neuroimag hs etiolog report system coagulopathi genet acquir patholog iatrogen focal cerebrovascular lesion brain arterioven malform cavern malform aneurysm tumor vascular sever scale use measur outcom glasgow outcom score gos king outcom score head injuri koschi modifi rankin scale mrs pediatr stroke outcom measur psom studi describ treatment risk lesion studi describ neurocrit care manag includ rais icp seizur vasospasm blood pressur predictor poor outcom includ ethnic comorbid locat bleed hematoma total brain volum motor cognit outcom follow independ pattern studi report cognit outcom rehabilit transit care model interdisciplinari approach manag hs urgent need inform larger cohort studi target key clinic question eg develop field guid clinician manag patient hs reproduc intern
|
D000083302;D020521
|
T047
|
36,344,020
|
acut hospit manag pediatr stroke field pediatr stroke histor hamper limit evid small patient cohort howev landscap childhood stroke rapid chang due part increas awar import pediatr stroke emerg dedic pediatr stroke center care pathway alert system acut pediatr stroke manag hing time diagnosi confirm neuroimag appropri consider recan therapi implement neuroprotect measur attent secondari prevent pediatr stroke high heterogen etiolog manag strategi must individu determin child under stroke etiolog essenti appropri tailor hyperacut stroke manag determin best approach secondari prevent herein review method recognit diagnosi manag current knowledg gap promis research pediatr stroke
|
D020521
|
T047
|
36,344,019
|
pediatr moyamoya biomark narrow knowledg gap moyamoya progress cerebrovascular disord lead stenosi arteri distal intern carotid proxim middl cerebr proxim anterior cerebr arteri circl willi typic network collater form bypass stenosi maintain cerebr blood flow moyamoya progress affect anterior circul common posterior circul cerebr blood flow becom increas reliant extern carotid suppli children moyamoya increas risk ischem symptom includ stroke transient ischem attack tia addit cognit declin may occur time even absenc clinic stroke standard care stroke prevent children symptomat moyamoya revascular surgeri treatment children asymptomat moyamoya revascular surgeri howev remain controversi therefor biomark need assist diagnosi also determin ischem risk identifi best surgic candid review discuss current knowledg well gap research relat pediatr moyamoya biomark includ neurolog present cognit neuroimag genet biolog biomark diseas sever ischem risk
|
D002548;D009072;D020521
|
T061;T047
|
36,344,018
|
cerebr arteriopathi childhood current approach half previous healthi children present first arteri ischem stroke cerebr arteriopathi cerebr arteriopathi childhood congenit reflect abnorm vessel develop acquir caus disrupt vascular homeostasi distinguish differ type cerebr arteriopathi children challeng great clinic valu may dictat differ diseas treatment cours clinic radiolog outcom furthermor children stroke due specif arteriopathi exhibit distinct featur compar stroke due caus differ type arteriopathi featur becom crucial manag pediatr stroke choos appropri diagnost treatment strategi object articl provid reader comprehens date review classif symptom diagnosi treatment outcom cerebr arteriopathi children
|
D002539;D020521;D002561
|
T047
|
36,344,013
|
secondari use data extract clinic inform system assess adher tidal volum impact outcom extract data clinic inform system automat calcul high resolut qualiti indic assess adher recommend low tidal volum
|
D012121;D007362
|
T061;T073;T093
|
36,344,012
|
intermedi tidal volum accept option ventil patient acut respiratori distress syndrom evid prove low surpass high tidal volum v acut respiratori distress syndrom ard intermedi v common set ard patient demonstr effect low v non ard patient effect intermedi v ard studi object studi
|
D012121;D012128
|
T061;T047
|
36,344,010
|
review util routin mortal review among death general intern medicin ward canadian tertiari care hospit hospit morbid mortal review common qualiti assur activ intend uncov latent unrecognis system issu contribut prevent advers event patient harm mortal review may routin mandat hospit polici accredit purpos howev patient care certain specialti general intern medicin gim affect substanti burden chronic diseas advanc age frailti limit life expect mani death could view reason forese unrel poor qualiti care
|
D000086382
|
T047;T067
|
36,344,008
|
comprehens self track blood glucos lifestyl mobil applic manag gestat diabet studi protocol randomis control trial emom gdm studi gestat diabet gdm caus various advers short term long term consequ mother child incid increas global far promis digit health intervent gdm manag involv healthcar profession provid guidanc feedback princip aim studi evalu effect comprehens real time self track emom gdm mobil applic app glucos level women gdm broad differ matern neonat outcom
|
D016640;D063731
|
T047;T170
|
36,344,007
|
agreement laboratori base non laboratori base cardiovascular risk chart cross section analysi nation health survey peru determin agreement cardiovascular diseas cvd risk predict comput non laboratori base model laboratori base model nation repres sampl peruvian adult
|
D002318;D003920
|
T047
|
36,344,006
|
updat systemat review australian school base prevent programm alcohol drug review protocol adolesc onset substanc use associ neurodevelopment social psycholog harm thus alcohol drug prevent programm essenti promot health well period school uniqu posit deliv prevent programm last decad seen larg expans school base alcohol drug prevent programm australia warrant updat comprehens review conduct teesson et al propos review aim identifi school base substanc use prevent programm triall australia sinc evalu efficaci identifi intervent compon associ effect assist school identifi adopt effect evid base programm inform futur programm develop evalu polici
|
D006293;D019966
|
T033;T058;T170;T048
|
36,344,005
|
compar restrict versus liber oxygen strategi trauma patient traumox trial protocol randomis clinic trial supplement oxygen common use trauma patient although may lead hyperoxaemia associ pulmonari complic increas mortal primari object trial traumox compar restrict versus liber oxygen strategi first hour follow trauma
|
D000086402;D000086382
|
T005;T067;T047
|
36,344,004
|
dietari andor physic activ intervent women overweight obes prior fertil treatment protocol systemat review individu particip data meta analysi dietari andor physic activ intervent often recommend women overweight obes first step prior fertil treatment howev randomis control trial rcts far shown inconsist result therefor propos individu particip data meta analysi ipdma evalu effect safeti dietari andor physic activ intervent women infertil overweight obes reproduct matern perinat outcom explor subgroup women benefit specif intervent combin treatment covari interact
|
D007246;D050177
|
T033;T046
|
36,344,003
|
cohort profil risk risk factor femal breast cancer treatment childhood adolesc cancer intern pool cohort intern consortium pool studi subsequ malign childhood adolesc cancer establish address gap knowledg risk risk factor breast cancer subsequ childhoodadolesc cancer pool individu patient data seven cohort initi pool cohort focus three clinic relev question regard treatment relat subsequ breast cancer risk femal survivor risk relat low dose radiotherapi exposur chest specif chemotherapi agent attain age
|
D001943;D009369;D000073116;D016609;D000970
|
T121;T109;T201;T191;T101
|
36,344,002
|
effect tele exercis rehabilit intervent women high risk osteoporot fractur studi protocol randomis control trial premenopaus postmenopaus osteoporosi associ fragil fractur major public health problem exercis especi moder high intens impact exercis recommend effect low cost non pharmacolog strategi bone strength improv howev evid fractur risk limit addit maintain regular train current problem therefor studi aim conduct randomis control trial moder high intens tele exercis intervent use tele rehabilit app quantifi effect vertic fractur fall prevent women high risk osteoporot fractur
|
D058866;D000069350
|
T047;T058
|
36,344,001
|
intervent support mental health well front line healthcar worker hospit pandem evid review synthesi pandem negat impact healthcar worker hcw mental health well caus addit feel anxieti depress moral distress post traumat stress comprehens review evid synthesi hcw mental health well intervent pandem report mental health outcom conduct address two question mental health support intervent report recent pandem effect improv mental health well hcws mobil app design implement support hcws mental health well pandem
|
D058873;D000086382
|
T047;T067
|
36,344,000
|
communiti collabor improv access outcom breast cancer reconstruct protocol mix method qualit research studi breast reconstruct play import role mani restor form function breast mastectomi howev rate breast reconstruct usa vari signific race ethnic socioeconom status lower rate breast reconstruct non white women women lower socioeconom status may reflect complex interplay patient physician factor access care remain unknown communiti specif barrier may impact receipt breast reconstruct
|
D001943;D016462
|
T061;T191
|
36,343,999
|
sync qualit investig patient experi atrial fibril percept weight manag explor way enhanc design risk factor manag weight loss servic peopl overweightobes atrial fibril af
|
D001281
|
T047;T046
|
36,343,998
|
socioeconom status modif atherosclerot cardiovascular diseas risk predict epidemiolog analysi use data atherosclerosi risk communiti studi examin whether relationship pool cohort equat pce predict year risk atherosclerot cardiovascular diseas ascvd absolut risk ascvd modifi socioeconom status ses
|
D002318;D050197
|
T047;T046
|
36,343,997
|
develop spread framework support scale de implement strategi mix method studi aim increas understand scale de implement strategi identifi determin process develop determin framework
|
D012107;D003695
|
T093;T062;T096;T170;T081;T058;T169
|
36,343,996
|
understand mental health impact need public healthcar profession covid pakistan qualit studi dearth qualit studi constrain depth understand health servic provid perspect experi regard impact covid mental health studi explor mental health impact need public sector healthcar worker covid work secondari level tertiari level healthcar set pakistan
|
D000086382
|
T047;T067
|
36,343,995
|
studi protocol locoregion precis treatment hepatocellular carcinoma transarteri chemoembolis tactida clinic studi idarubicin dose select tissu respons surviv hepatocellular carcinoma hcc common caus cancer relat death often detect intermedi stage standard care intermedi stage hcc transarteri chemoembolis tace idarubicin ida promis drug despit fact tace use sever decad treatment success unpredict clinic trial design believ improv might achiev increas understand interact local pharmacolog tumour target hcc pathophysiolog metabolom molecular mechan drug resist
|
D006528;D016461;D008113
|
T061;T191
|
36,343,994
|
demograph behaviour occup risk factor associ sar cov infect uk healthcar worker retrospect observ studi healthcar worker hcws higher risk sar cov infect general popul group pivot healthcar system resili covid futur pandem investig demograph social behaviour occup risk factor sar cov infect among hcws
|
D000086402;D000086382
|
T005;T067;T047
|
36,343,993
|
covid vaccin hesit periconcept lactat women systemat review meta analysi protocol pandem covid diseas caus sever impact global govern consid vaccin effect measur control pandem howev mani peopl hesit receiv covid vaccin particular periconcept lactat women although research indic pregnant women covid higher risk advers pregnanc birth outcom well sever ill appear lack systemat comprehens evid preval determin covid vaccin hesit among periconcept lactat women result essenti investig periconcept lactat women vaccin view behaviour studi review articl vaccin hesit among periconcept lactat women assess impact covid vaccin hesit pandem
|
D000086663;D000086382
|
T200;T047;T067
|
36,343,992
|
less full time train ltft new norm cross section studi use uk wide onlin survey evalu traine view intent ltft interest less full time train ltft grow among doctor train ltft applic previous limit fulfil specif criteria childcar health reason health educ england hee recent complet pilot ltft third categori lifestyl choic recognis opportun canva traine perspect intent ltft implic workforc plan
|
D033182;D001291
|
T041
|
36,343,991
|
discret choic experi investig prefer psycholog intervent cardiac rehabilit cardiac rehabilit cr offer peopl recent experienc cardiac event often compris exercis educ psycholog care state prefer studi aim investig prefer attribut psycholog therapi intervent cr
|
D057240;D000072038
|
T061;T080
|
36,343,990
|
current practic attitud view provid pregnanc care women type diabet china qualit studi data spars healthcar need relat pregnanc among chines women type diabet td gap need healthcar provis china aim identifi need gap pregnanc care provis
|
D003922
|
T047
|
36,343,989
|
magnitud factor associ musculoskelet disord among patient diabet attend chronic care arba minch general hospit arba minch southern ethiopia cross section studi studi aim assess preval determin musculoskelet disord msds among patient diabet southern ethiopia
|
D002318;D003920;D009140
|
T047
|
36,343,988
|
effect insol adapt flip flop sandal persist heel pain protocol sham control randomis trial persist heel pain preval complaint affect popul insol adapt flip flop sandal altern treatment pain function individu persist heel pain show improv within week treatment studi consid foot postur biomechan prescrib insol persist heel pain verifi effect week treatment pain catastrophis studi investig effect insol adapt flip flop sandal pain intens function function walk capac pain catastrophis individu persist heel pain
|
D006365;D005534
|
T047;T023;T030
|
36,343,986
|
macular neovascularis patient osteogenesi imperfecta exhibit novel cola mutat osteogenesi imperfecta congenit diseas present vari degre connect tissu symptom includ suscept fractur growth disord hear loss discuss case macular neovascularis mnv result metamorphopsia decreas visual acuiti patient osteogenesi imperfecta exhibit novel cola gene mutat ptyr patient woman report experienc distort vision diminish visual acuiti right eye month well histori hear loss rapid improv exud chang suppress relaps achiev two intravitr inject ranibizumab furthermor sinc mnv occur slight inferior fovea centrali improv visual acuiti better previous report fragil bruch membran repres basi onset recurr relaps like patient exhibit mnv highlight need regular follow
|
D010013
|
T047
|
36,343,984
|
mandibular talon cusp rare dental anomali talon cusp rare dental anomali consist supernumerari project cingulum toward incis edg tooth cusp made enamel dentin pulpal tissu may may present occurr mandibular talon cusp rare entiti case report articl report case talon cusp mandibular central incisor along literatur review mandibular talon cusp report histori
|
D014096;D014071
|
T019;T190
|
36,343,983
|
combin hepatocellular carcinoma cholangiocarcinoma patient fontan associ liver diseas present rare case combin hepatocellular carcinoma cholangiocarcinoma woman histori univentricular congenit heart diseas requir multipl correct oper includ fontan procedur workup elev alpha fetal protein right hepat lobe lesion identifi biopsi show poor differenti hepatocellular carcinoma underw success segment liver resect final patholog demonstr combin hepatocellular carcinoma cholangiocarcinoma treat gemcitabineoxaliplatin adjuv chemotherapi evid recurr diseas month follow knowledg first case report success treatment rare malign set fontan associ liver diseas highlight import robust screen protocol patient popul semiannu screen develop primari liver malign start year post fontan continu heart liver transplant may perform import note cirrhosi pre requisit develop hepatocellular carcinoma cholangiocarcinoma patient
|
D006528;D008113;D018281;D001650
|
T191
|
36,343,982
|
immedi delay migrat onyx embolis renal collect system present case onyx embolis renal pseudoaneurysm follow partial nephrectomi collect system involv subsequ migrat onyx renal collect system result renal obstruct occur immedi embolis year embolis case requir ureteroscop surgic intervent first instanc piec remov use basket extract second laser lithotripsi use addit basket extract case embolis coil erod renal collect system second report case onyx migrat first ureteroscopi laser lithotripsi use patient well undergo surveil ultrasound ensur onyx migrat may consider patient pseudoaneurysm embolis especi set prior collect system damag
|
D017541;D017602;D004621
|
T061;T046
|
36,343,981
|
rare case high amylas pleural effus without pancreat oesophag ruptur malign high amylas pleural effus remain entiti includ wide varieti differenti pancreat oesophag ruptur malign pleural effus common encount clinic practic keep clinic pictur suggest pain abdomen preced respiratori complaint differenti hand case evalu contrast enhanc ct thorax abdomen reveal normal pancreat architectur abnorm communic note pancrea pleural space contrast oesophagogram done pancreat rule show evid leak patient underw upper gastrointestin endoscopi suggest ulcer fistul communic pleural space follow nasojejun feed clip fistul tract patient symptom improv
|
D010996;D010195;D005767;D009369
|
T047;T046;T191
|
36,343,977
|
compartment host microbiom tumor microbiota shape checkpoint immunotherapi outcom offer therapeut prospect host microbiom polymorph compartment compos distinct tissu microbiom research field cancer immunotherapi provid improv understand interact gastrointestin microbiom signific tumor associ microbiom recent grasp articl provid state art review tumor associ microbiom shed light local tumor microbiota shape anticanc immun influenc checkpoint immunotherapi outcom direct rout interact cancer cell immun cell microbiota tumor microenviron emphas advoc focus tumor associ microbiom addit spatial separ gut compart sinc mechan under checkpoint immunotherapi modul tumor associ microbiota remain larg elus futur research dissect pathway involv outlin strategi therapeut modul microb product within tumor microenviron detail knowledg mechan govern composit function qualiti tumor microbiom improv cancer immunotherapi advanc precis medicin solid tumor
|
D064307;D009369;D000069196
|
T032;T007;T191;T028;T001
|
36,343,976
|
inhibit dna methyl rna edit upregul immunogen rna transform tumor microenviron prolong surviv ovarian cancer novel therapi urgent need ovarian cancer oc fifth deadliest cancer women preclin work shown dna methyltransferas inhibitor dnmtis revers immunosuppress tumor microenviron oc inhibit dna methyltransferas activ transcript doubl strand ds rna includ transpos element dsrnas activ sensor cytoplasm trigger type interferon ifn signal recruit host immun cell kill tumor cell adenosin deaminas adar induc ifn signal edit mammalian dsrna nucleotid chang read g chang sequenc data edit dsrnas sens dsrna sensor thus adar inhibit type ifn respons negat feedback loop hypothes decreas adar edit would enhanc dnmti induc immun respons
|
D017393;D010051
|
T045;T191
|
36,343,971
|
improv surviv combin chemotherapi extern beam radiat therapi uterin carcinosarcoma evalu differ surviv recurr pattern stage iv uterin carcinosarcoma patient treat surgeri follow adjuv chemotherapi alon radiat alon combin chemotherapi radiat therapi
|
D014594;D002296
|
T191
|
36,343,969
|
covid public health social measur comprehens pictur six asian countri covid pandem last kind world chart way toward equit resili recoveri public health social measur phsms implement sinc begin pandem need made perman featur health system activ readili deploy tackl sudden surg infect go forward although phsms aim blunt spread virus turn protect live preserv health system capac also unintend consequ attribut import interact phsms accompani key indic influenc strength durat phsms element requir depth explor research employ case studi six asian countri name indonesia singapor south korea thailand philippin vietnam paint comprehens pictur phsms protect live livelihood popul nine typolog phsms emerg follow physic distanc border control person protect equip requir transmiss monitor surg health infrastructur capac surg medic suppli surg human resourc vaccin avail roll social econom support measur key indic influenc strength durat phsms follow size communiti transmiss number sever case mortal health system capac vaccin coverag fiscal space technolog interact phsms synergist inhibit depend various contextu factor fundament phsms oper silo suit phsms complementari requir ensur live livelihood safeguard equiti len achiev strong govern structur communiti engag also requir level health system
|
D000086382
|
T047;T067
|
36,343,968
|
digit market formula babi food negat influenc breast feed complementari feed cross section studi video record parent exposur mexico littl evid associ digit market formula babi food infant young child feed iycf practic
|
D001942;D041943
|
T055;T058;T040;T168
|
36,343,937
|
regul oxid stress inflammatori respons human retin pigment epitheli cell age relat macular degener amd eye diseas caus impair vision lead blind incid amd increas age retin pigment epitheli rpe cell maintain retin homeostasi support function photoreceptor pathogenesi amd degener rpe cell preced photoreceptor cell death rpe cell suscept oxid stress chronic inflamm involv nucleotid bind domain leucin rich repeat pyrin domain nlrp inflammasom activ impair autophagi challeng face age rpe cell amd two type amd dri wet diseas form choroid neovascular typic wet amd anti vascular endotheli growth factor anti vegf inject use prevent progress diseas curat treatment cure dri diseas form antioxid propos potenti treatment option age import risk factor amd tobacco smoke import environment risk factor control hydroquinon cytotox immunotox carcinogen pro oxid compon tobacco smoke aim phd thesi studi hydroquinon induc oxid stress nlrp inflammasom activ human rpe cell arp cell age relat eye diseas studi are formul incl omega fatti acid vitamin c e copper zinc lutein zeaxanthin clinic investig po dose combin dietari supplement amd patient evalu possibl treatment restrain option amd resvega tabl similar kind product are ad resveratrol mani compon incorpor within resvega consid belong normal antioxid defenc system retina anoth aim evalu effect resvega hydroquinon induc oxid stress nlrp inflammasom activ induc impair protein clearanc result studi reveal hydroquinon elev activ nadph oxidas subsequ mediat product reactiv oxygen speci ros predispos rpe cell degener reduc level vascular endotheli growth factor vegf pigment epithelium deriv factor pedf hydroquinon induc nlrp independ il releas nlrp accumul insid il prime cell resvega treatment reduc extent hydroquinon induc ros product nlrp inflammasom activ evok impair protein clearanc thus resvega allevi hydroquinon impair protein clearanc induc stress human rpe cell studi need exampl reveal optim rout administr target cell retina sinc oxid stress nlrp inflammasom activ import contributor develop amd repres signific treatment target
|
D014028;D057135
|
T033;T047;T069
|
36,343,936
|
rapid eye movement sleep initi dopamin signal basolater amygdala mice sleep cycl altern rem nrem sleep mechan cycl generat total unknown found period transient increas dopamin level amygdala nrem sleep termin nrem sleep initi rem sleep mechan also play role cataplect attack patholog intrus rem sleep wake narcolept
|
D012895;D066272
|
T023;T041;T042
|
36,343,935
|
begin develop magnetoencephalographi system use superconduct spintron sensor electroencephalographi eeg magnetoencephalographi meg noninvas imag method human brain function tempor resolut millisecond order meg theoret superior spatial resolut eeg howev weak signal meg measur superconduct quantum interfer devic squid squid meg equip extrem high manufactur run cost moreov theoret high spatial resolut practic limit necessari setback distanc sensor scalp dewar vessel contain liquid helium squid requir thick vacuum wall latest develop room temperatur magnetomet tunnel magnet resist tmr sensor may solv problem setback distanc meg scanner review person research histori meg era singl channel squid meg present era singl channel tmr meg also propos major consider futur develop meg system
|
D015225;D001921
|
T060;T023
|
36,343,934
|
motor neuron involv rfc canvasspectrum disord cerebellar ataxia neuropathi vestibular areflexia syndrom canva character triad cerebellar ataxia bilater vestibular impair sensori neuropathi respons anatom region sensori disturb canva report dorsal root ganglion suggest neuronopathi rather neuropathi pathomechan peripher nervous system disord earli motor neuron involv consid rare canva etiolog canva includ homozyg pentanucleotid repeat expans within rfc gene result divers phenotyp motor deficit brisk reflex extensor plantar respons spastic upper motor neuron muscl wast weak cramp fascicul lower motor neuron canva patient aaggg repeat expans may show motor neuron involv consider variat report frequenc contrast although patient acagg repeat expans also show motor neuron involv frequenc remain elus
|
D002524;D010523
|
T033;T184;T047
|
36,343,933
|
peripher neuropathi rfc canvasspectrum disord recent biallel expans aaggg repeat rfc report caus cerebellar ataxia neuropathi vestibular areflexia syndrom mutat also report select nervous disord includ pure sensori axon polyneuropathi thus multisystem disord caus mutat consid rfc relat spectrum disord review previous report rfc relat spectrum disord aspect neuropathi
|
D000071699;D002524;D010523
|
T033;T184;T047
|
36,343,932
|
cerebellar ataxia rfc spectrum disord replic factor c subunit rfc spectrum disord character varieti symptom includ cerebellar ataxia sensori neuropathi vestibular dysfunct may occur singular various combin rfc spectrum disord may mimic clinic manifest imag find multipl system atrophi describ preval genet featur imag find rfc spectrum disord
|
D002524;D010523;D019578
|
T033;T184;T047;T046
|
36,343,931
|
chronic cough canva among patient rfc spectrum disord repres phenotyp cerebellar ataxia neuropathi vestibular areflexia syndrom canva least known manifest chronic paroxysm spasmod dri cough chronic cough key diagnost featur rfc relat diseas often first symptom case preced neurolog symptom ataxia sensori disturb year although pathogenesi cough remain unclear possibl impair vagus nerv includ affer pathway cough reflex cerebellum would contribut generat cough
|
D010523;D002524
|
T033;T184;T047
|
36,343,930
|
vestibular dysfunct replic factor c subunit rfc spectrum disord replic factor c subunit rfc gene relat spectrum disord cerebellar ataxia neuropathi vestibular areflexia syndrom canva bilater vestibular dysfunct case canva present paper show repeat extens aaggg intron region rfc gene show bilater vestibular dysfunct calor test vestibular evok myogen potenti video head impuls test rotari chair test visual enhanc vestibulo ocular reflex test also reveal abnorm suggest presenc combin lesion cerebellum brainstem includ vestibular nuclei
|
D002524
|
T033;T184;T047
|
36,343,929
|
neuropatholog find cerebellar ataxia neuropathi vestibular areflexia syndrom cerebellar ataxia neuropathi vestibular areflexia syndrom canva character neuropatholog chang loss purkinj cell degener posterior column spinal cord peripher nervous system canva associ loss ganglion cell dorsal root vestibular ganglia patient may show degener inferior olivari nucleus corticospin tract facial trigemin ganglia research warrant determin whether differ lesion distribut attribut differ genet abnorm combin date aggreg abnorm protein intranuclear inclus bodi characterist diseas identifi nervous system
|
D000071699;D002524;D010523
|
T033;T184;T047
|
36,343,928
|
rfc gene function intron repeat expans caus cerebellar ataxia neuropathi vestibular areflexia syndrom biallel intron repeat expans rfc gene report caus cerebellar ataxia neuropathi vestibular areflexia syndrom canva clinic featur includ late onset cerebellar ataxia sensori neuropathi neuronopathi bilater vestibular impair autonom dysfunct chronic cough pyramid sign parkinson repeat conform heterogen observ along possibl phenotyp genotyp correl molecular pathogenesi remain uncov
|
D000071699;D002524;D010523;D001342
|
T033;T184;T047
|
36,343,927
|
rfc canvasspectrum disord histor detail clinic divers cerebellar ataxia neuropathi vestibular areflexia syndrom canva refer multi system neurodegen disord middl age onset main present progress imbal imbal attribut isol combin impair cerebellar propriocept vestibular system chronic spasmod cough usual preced neurolog symptom serv use diagnost clue canva diagnost criteria propos canva base cardin featur biallel intron aaggg repeat expans aaggg exp replic factor complex subunit gene rfc identifi genet contributor canva acggg exp rfc subsequ confirm causat factor canva genet screen rfc shown canva overlook entiti patient cerebellar ataxia sensori neuropathi highlight restrict phenotyp exclus involv one aforement system phenotyp spectrum rfc relat disord expand sinc discoveri aaggg exp acggg exp rfc studi report atyp featur includ parkinson motor neuron involv cognit declin sleep disord current wide varieti clinic condit associ biallel intron pentanucleotid repeat expans rfc classifi rfc canvasspectrum disord
|
D002524;D010523
|
T033;T184;T047
|
36,343,647
|
women health issu thrombosi haemostasi last coupl year sex specif health issu continu gain attract physician differ medic special sex differ describ eg pathogenesi mortal patient affect covid metabol regul cancer mechan field haemostasi mani aspect concern risk factor clinic present manag thromboembol diseas bleed disord also display sex differ
|
D000086382;D013927;D001778
|
T047;T046;T067
|
36,343,617
|
autoimmun enceph autoimmun encephalitid form heterogen group neurolog psychiatr diseas antibodi mediat enceph autoantibodi pathogen direct caus enceph antibodi associ enceph paraneoplast time autoantibodi serv diagnost biomark abl predict under tumour
|
D050031;D004660
|
T047
|
36,343,352
|
histori suicid attempt clozapin treatment veteran schizophrenia schizoaffect disord object evalu whether histori suicid attempt increas odd receiv clozapin treatment veteran schizophrenia schizoaffect disord
|
D003024;D012559;D014150;D014728;D011618
|
T121;T098;T109;T039;T048
|
36,343,326
|
littl correl found immigr entri covid infect rate unit state relationship immigr entri covid spread unit state driven much polit discuss polici includ implement titl center diseas control prevent examin relationship covid spread immigr entri compar immigr flow local covid rate use estim border cross border patrol visa issu depart labor season guest worker program analysi captur season guest worker entri nation level show statist signific relationship covid rate analys southwest border cross show small statist signific relationship immigr flow covid rate border counti percent increas local case per resid addit immigr howev estim modest compar fact half month month chang case rate greater percent furthermor modest increas becam nonsignific increas local vaccin rate estim also maintain statist signific analyz altern approach find support exist evid short term impact immigr flow local covid rate minim
|
D000086382;D054242
|
T047;T098;T067
|
36,343,325
|
financi coach offer new path healthi futur tax assist financi literaci educ program boston medic center help famili rise poverti
|
D000071252
|
T065
|
36,343,324
|
pandem recess effect mortal us first year covid almost excess death us march februari result two often counterbalanc mechan predict chang unemploy rate occur period refer recess effect predict pandem effect reflect direct consequ sar cov infect covid accompani impact health medic care chang mortal caus greater jobless use data center diseas control prevent studi decompos total mortal period pandem recess effect addit estim sex race ethnic age fourteen caus although pandem effect increas mani type mortal recess effect reduc type mortal without recess effect would near death actual occur howev dispar impact particular extern caus vehicular alcohol relat fatal homicid rose strong pandem effect contrast recess effect account greater share rise drug mortal offset pandem recess effect result decreas number suicid understand divers impact provid use lesson polici effort mitig current futur health pandem
|
D000086382;D013405
|
T033;T047;T067
|
36,343,323
|
state evict moratorium covid pandem associ improv mental health among peopl rent respons covid pandem mani us state implement evict moratorium evid evict file year show short term declin evict file studi examin short term effect state evict moratorium mental health status renter employ nation repres data behavior risk factor surveil system tripl differ design compar renter homeown leverag state differ moratorium time forti three state washington dc implement evict moratorium vari scope enforc moratorium target whole evict process includ earli stage wherea other focus later stage evict found state moratorium associ improv mental health includ fewer day good mental health past thirti day lower likelihood frequent mental distress fourteen day good mental health past thirti day overal evid studi point potenti short term benefit state evict moratorium mental health well renter would import consid formul polici affect residenti stabil
|
D000086382;D001523
|
T047;T067;T048
|
36,343,322
|
excess death time dual public health crise pars effect pandem drug overdos recess detail examin death us caus age suggest recess contribut excess death overal howev high excess mortal occur drug overdos recess effect covid pandem effect understand risk heighten substanc use mortal help mitig risk next pandem
|
D000086382;D062787
|
T047;T037;T067
|
36,343,321
|
eas cash assist rule covid associ reduc day poor physic mental health unemploy rate soar begin covid pandem us increas financi stress affect physic mental health temporari assist needi famili tanf primari cash assist program low incom famili us benefit condit work activ subject suspens howev mani state loosen requir pandem use tanf polici data data behavior risk factor surveil system period januari decemb tripl differ design found general protect effect support chang tanf poor physic mental health day bing drink covid pandem like tanf particip exampl provid emerg cash benefit alreadi particip tanf waiv work requir waiv paus sanction automat recertifi benefit associ reduct number mental unhealthi day studi provid support increas generos eas administr burden safeti net program buffer negat impact public health econom crise
|
D012946;D000086382
|
T047;T095;T067
|
36,343,320
|
evid child tax credit expans effect well mental health parent us establish child tax credit ctc offer payment parent depend children help defray child rear cost temporari expans ctc increas size payment extend payment famili low earn distribut payment month instead annual quasi experiment evid us experiment evid low middl incom countri show moder larg cash transfer improv subject well mental health estim ctc expans effect subject well mental health adult recipi use data understand america studi nation repres survey respond uniqu respond children found evid ctc expans signific short term impact measur life satisfact anxieti depress symptomolog among adult recipi specul null effect may due expans temporari natur
|
D008603;D013660
|
T081;T064;T041
|
36,343,319
|
racial ethnic dispar pandem era unemploy insur access implic health well research demonstr receiv unemploy insur decreas mental health problem research also found racial ethnic dispar unemploy insur receipt result differ work histori locat examin popul disproportion affect job loss unemploy insur exclus use survey servic worker singl citi parent young children overwhelm elig work histori covid pandem worker identifi white non hispan sampl like get laid white worker among laid worker white worker experienc similar increas materi mental health difficulti similar gain receiv unemploy insur howev worker less like white worker receiv unemploy insur result indic unemploy insur unreal potenti reduc materi health dispar polici implement make coverag effect equit increas access
|
D058873;D000086382
|
T047;T067
|
36,343,318
|
excess death continu unit state root caus address estim excess death begin captur devast health impact covid pandem us death occur larger number american experi diseas complic delay access care increas socioeconom precar take toll high incom countri experienc high death rate pandem decad american experienc poorer health outcom peopl peer countri defici health care system advers socioeconom condit unhealthi physic social environ system racism polici jeopard health pandem expos problem area highlight power polici maker includ state govern alter health outcom
|
D058873;D000086382
|
T047;T067
|
36,343,317
|
confront racism pediatr care primari care pediatrician call profess address racism pediatr care
|
D063505
|
T054
|
36,343,316
|
higher covid vaccin narrow dispar us citi paid sick leav compar without paid sick leav provid worker paid time receiv covid vaccin recov potenti vaccin advers effect hypothes us citi paid sick leav would higher covid vaccin coverag narrow coverag dispar without polici use counti level vaccin data paid sick leav data thirti seven larg us citi estim associ citi level paid sick leav polici vaccin coverag work age popul repeat analysi use coverag popul age sixti five older negat control also examin associ neighborhood social vulner citi paid sick leav polici percent higher vaccin coverag citi without polici found stronger associ paid sick leav vaccin social vulner neighborhood compar least social vulner one associ popul age sixti five older paid sick leav polici associ higher covid vaccin coverag narrow coverag dispar increas access polici may help increas vaccin reduc inequ coverag
|
D018582;D000086382
|
T078;T067;T079;T081;T047
|
36,343,315
|
groceri purchas chang associ north carolina covid food assist incent program mani low incom american experi food insecur may exacerb econom instabl earli stage covid pandem studi assess impact healthi help short term fruit veget incent program aim allevi food insecur improv diet qualiti supplement nutrit assist program particip groceri purchas use transact data larg supermarket chain north carolina compar healthi help particip purchas key food group program purchas control shopper particip feder food assist program period healthi help enrol associ increas month spend fruit veget nut legum increas gram fiber per kilocalori purchas shift composit food purchas relat control shopper find suggest program increas healthi food purchas also increas dollar sale particip retail averag particip use full benefit futur research explor factor associ non underus benefit inform program design outreach
|
D063105;D000086382
|
T047;T064;T067;T057
|
36,343,314
|
mandat narrow gender gap paid sick leav coverag low wage worker us paid sick leav help worker recov ill manag care oblig protect public health yet access paid sick leav remain limit unequ unit state draw survey servic sector worker collect period shift project document limit access paid sick leav stark gender inequ women less like men paid sick leav part time employ gender segreg industri subsector explain part gender dispar howev state local mandat paid sick leav worker worker far like report access benefit gender gap elimin guarante paid sick leav worker would offer rang benefit worker employ public health also offer benefit reduc gender inequ
|
D018582;D012456
|
T078;T081;T079
|
36,343,313
|
medicar bundl payment care improv advanc model impact high risk beneficiari medicar bundl payment care improv advanc model bpci voluntari altern payment model particip hospit held account nineti day episod care meet spend target hospit must either decreas util attract less sick patient popul could lead elimin necessari care avoid patient medic social vulner use public avail data bpci particip along medicar claim period examin patient select chang medicar payment key clinic outcom among three group patient frailti patient multimorbid patient dual enrol medicar medicaid found consist chang patient select associ bpci particip patient frailti multimorbid dual enrol expens baselin medicar payment decreas similar group compar lower risk patient differenti negat chang clinic outcom bpci particip nonparticip among patient medic social vulner
|
D000073496;D064872
|
T033;T184;T046;T061
|
36,343,312
|
rise cross market hospit system market power us although hospit consolid within market well document consolid across market even though econom theori predict evid emerg cross market hospit system rais price exert market power across market negoti common custom primarili insur studi analyz hospit system use american hospit associ annual survey databas defin hospit geograph market commut zone link worker place employ share communiti hospit us part hospit system increas percent percent result hospit within system system percent own hospit multipl commut zone part percent hospit target merger acquisit locat differ commut zone acquir base market power differ among hospit system number system urban commut zone could potenti exert enhanc cross market power increas thirti seven system fifti seven system increas percent increas cross market hospit system warrant concern scrutini potenti anticompetit impact hospit system exert market power across market negoti common custom
|
D004465;D007348
|
T058;T057
|
36,343,311
|
use willing use video telehealth covid pandem examin use willing use video telehealth covid pandem longitudin follow cohort februari march use willing use increas among near subgroup larg increas among black adult adult lower educ attain march black adult adult age high incom adult report greatest willing use video telehealth
|
D000086382;D017216
|
T047;T058;T067
|
36,343,310
|
racial ethnic inequ covid mortal within carcer set analysi texa prison covid pandem taken heighten toll peopl incarcer prison unit state incarcer experienc higher rate infect mortal us popul general less well known degre covid outcom differ among incarcer popul especi race ethnic signific differ found among us popul whole knowledg gap part due lack report covid outcom race ethnic state prison system shed light topic analyz mortal pattern popul incarcer texa state prison facil year begin april first year begin april covid pandem use uniqu data set roster inform texa depart crimin justic medic examin record covid mortal time higher black hispan popul respect compar white popul texa prison strategi covid mitig carcer set vaccin decarcer includ equiti compon minim dispar
|
D000086382
|
T047;T067
|
36,343,275
|
clinic studi arteri percheron infarct arteri percheron aop infarct rare caus acut alter mental status am character bilater paramedian thalam infarct aim studi review clinic manifest radiolog pattern treatment prognosi patient aop infarct retrospect case seri includ patient aop infarct medic center taiwan defin aop infarct acut bilater paramedian thalam infarct magnet reson imag patient categor addit aop territori involv determin outcom modifi rankin scale discharg among includ patient am common present identifi two patient bilater vertebr arteri va five unilater posterior cerebr arteri pca one bilater pca occlus atherosclerosi common presum etiolog two eight patient favor unfavor prognos respect pca occlus rather va ba occlus common angiographi residu symptom often result signific disabl discharg basilar tip syndrom may share indistinguish thalam infarct pattern aop infarct could differenti angiographi infarct territori
|
D013788;D001157
|
T023;T047
|
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