PMID
int64 35.7M
36.4M
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36,292,596
|
cerebellar abiotrophi australian work kelpi associ two major risk loci autosom recess form inherit cerebellar abiotrophi ca character degener purkinj granul cell cerebellar cortex occur australian work kelpi dog breed clinic sign ca includ ataxia head tremor motor coordin wide base stanc high step gait investig clinic patholog featur indic two close relat diseas differ age onset genom wide associ studi ca affect normal healthi kelpi identifi two signific associ loci one cfa second cfa dog homozyg risk haplotyp cfa dog show clinic sign ten week age missens variant sixth exon disruptor telomer silenc like dotlprq exon leucin rich repeat ig domain contain lingoprc cfa segreg associ risk marker incomplet penetr affect dog homozyg risk haplotyp cfa later onset ataxia missens variant exon vacuol membran protein vmp ppq cfa segreg fulli penetr mendelian recess later onset ca across mammal varieti causat loci far identifi influenc cerebellar disord reinforc complex pathway contribut cerebellar develop function pathophysiolog mechan may lead cerebellar ataxia
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D004283;D002526;D002524;D019636
|
T033;T184;T047
|
36,292,595
|
microrna epitheli mesenchym transit fuch endotheli corneal dystrophi review mirna express connect epitheli mesenchym transit studi fuch endotheli corneal dystrophi fecd
|
D035683;D005642
|
T123;T047;T114
|
36,292,594
|
genom predictor brisk walk associ elit sprinter status brisk walker physic activ taller reduc bodi fat greater physic fit muscl strength aim studi determin whether genet variant associ increas walk pace overrepres elit sprinter compar control total singl nucleotid polymorph snps previous identifi genom wide associ studi gwas self report walk pace european individu explor relat sprinter status genotyp russian elit sprinter control perform use microarray technolog favor ie high speed walk allel snps fhl rs c slca rs c ef rs znf rs gdf rs g pparg rs aut rs igsf rs cct rs crtac rs adam rs g corf rs akap rs c crtc rs nrxn rs g identifi posit associ sprinter status p amp lt igsf rs surviv correct multipl test p link p increas proport fast twitch muscl fiber vastus laterali physic activ men n polygen analysi reveal individu favor allel snps increas odd ratio elit sprinter compar allel p amp lt use uk biobank data also establish associ favor allel low bmi fat percentag allel increas handgrip strength allel increas height fat free mass conclus identifi new genet marker associ sprinter status
|
D055106;D018737
|
T063;T081;T040
|
36,292,593
|
singl cell sequenc reveal mechan persist truncus arteriosus format pdgfr pdgfr doubl knockout cardiac neural crest cell persist truncus arteriosus pta uncommon complex congenit cardiac malform account congenit heart diseas chds caus defici embryon heart outflow tract oft septat remodel pdgfr pdgfr doubl knockout dko cardiac neural crest cell cnccs report caus pta under mechan remain unclear construct pta mous model pdgfr pdgfr doubl knockout pax cnccs describ condens failur oft septum cncc deriv cell due disturb cell polar dko group addit explor mechan singl cell rna sequenc found two main cell differenti trajectori vascular smooth muscl cell vsmcs cardiomyocyt cms mesenchym cell mss respect interrupt dko group process cm differenti vsmc stagnat transit cm like state contribut failur oft remodel muscular septum format hand penk transit ms ii cluster close relat cell condens oft septum disappear led oft septat absenc direct conclus disturb cncc deriv cell caus pdgfr pdgfr knockout lead oft septat disord occurr pta
|
D009432;D014339
|
T018;T025;T019
|
36,292,592
|
rare diseas educ outsid classroom clinic evalu rare compass program undergradu medic student launch rare compass program first intern educ program pair medic student rare diseas patient order enhanc exposur comfort rare diseas part ongo qualiti improv studi retrospect review four year particip registr data conduct program evalu rare compass program studi period student particip repres associ american medic colleg aamc member medic school rare diseas volunt despit requir person interact student volunt interact person video messag email correspond respect p limit post particip survey student match resid special indic would recommend program peer find suggest rare compass program design increas medic student engag rare diseas patient broad appeal serv novel case studi extracurricular initi support non profit organ augment medic train experi improv understand import often neglect perspect
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D013337;D004504
|
T065;T097
|
36,292,591
|
compar transcriptom srnaom analys reveal regulatori mechan fruit ripen spontan earli ripen navel orang mutant wild type complex molecular regulatori network play import role develop ripen fruit lead signific differ appar characterist compar transcriptom srnaom analys perform reveal regulatori mechan fruit ripen spontan earli ripen navel orang mutant ganqi citrus sinensi l osbeck wild type newhal navel orang studi transcript level total gene found differenti express mt wt four fruit develop stage rna seq addit total differenti express mirna found four period belong famili integr analysi transcriptom srnaom data reveal factor regul mechan format earli ripen trait first secondari metabol materi especi endogen hormon carotenoid cellulos pectin obvious chang fruit ripen mt wt second found larg number differenti express gene ppc snrk jaz arf pg pe involv plant hormon signal transduct starch sucros metabol suggest import metabol pathway fruit ripen third express pattern sever key mirna target gene citrus fruit develop ripen stage examin csi mir csi mir csi mir csi mir mirn suppress specif transcript factor spls arf nac lac tcps thought import regul involv citrus fruit develop ripen present studi analyz ripen relat regulatori factor multipl perspect provid new insight molecular mechan oper earli ripen navel orang mutant ganqi
|
D032084;D035683
|
T168;T123;T002;T114
|
36,292,590
|
chloroplast genom analysi genet inform authent five barleria speci order authent genom inform barleriacristata l b lupulina lindl b repen nee b siamensi craib b strigosa willd cp genom investig reveal general structur total size bp genom encod total gene includ cds trna rrna gene detail found follow differ number type ssrs ident gene content adjac border region except b strigosa reveal shorter ndhf gene sequenc lack ycf gene slight differ genet distanc valu use speci identif three distinct gap nucleotid variat speci locat intergen spacer region lsc cds ssc three effect molecular marker deriv diverg hotspot region includ ccsa ndhd ndha ndhh rps ycf genet relationship deriv cp genom cds phylogenet tree barleria genera acanthacea differ famili scrophulariacea phrymacea show similar result six barleria speci monophylet group inner outer outgroup found perfect discrimin result help authent five barleria speci six genera acanthacea
|
D054628;D027901
|
T002;T028
|
36,292,589
|
free fatti acid overload target mitochondria gene express analysi palmit acid treat endotheli cell lipotox known caus cellular dysfunct death non adipos tissu major caus lipotox accumul satur free fatti acid ffa palmit acid pa common satur fatti acid found human bodi endotheli cell form blood vessel first non adipos cell encount ffa bloodstream ffa overload direct impact metabol evid chang occur mitochondria studi chang pa treat human coronari arteri endotheli cell hcaec dataset obtain gene express omnibus geo analyz obtain differenti express gene deg nucleus mitochondria function pathway enrich analys perform deg result show nuclear mitochondri deg implic sever process eg reactiv oxygen speci ros product mitochondri fusion fission ca sequest membran transport electron transport chain process apoptosi better understand role ffa endotheli cell damag deg lead futur experi base find
|
D019308;D005230
|
T123;T122;T109
|
36,292,588
|
intrins disord bap associ uveal melanoma specif subvari uveal melanoma um associ increas rate metastasi compar subvari brca breast cancer gene associ protein bap encod gene link aggress behavior um
|
D064267;D014604
|
T123;T191;T116
|
36,292,587
|
incident find studi particip research oblig technolog advanc genom test becom commonplac incident find discoveri unrel result increas american colleg genet genom acmg establish recommend return patholog variant gene clinic set base medic action condit gene link prevent treatabl diseas howev lack polici research set pose serious ethic dilemma research potenti threaten particip trust willing contribut process signific risk benefit
|
D033162;D023281
|
T033;T091
|
36,292,586
|
popul structur finless porpois neophocaena phocaenoid discov coastal water republ korea finless porpois neophocaena phocaenoid cuvier distribut coastal water asia throughout indonesia east far north taiwan strait finless porpois declar critic endang wwf world wide fund natur rate vulner iucn red threaten speci list sinc speci distribut near coast mani interact human effect conserv speci requir studi genet divers popul studi sampl obtain bycatch strand individu east south west sea korean porpois main distribut compar bp mtdna sequenc control region pairwis fixat indic fst reveal two popul differ signific fst p contrast high level genet differenti gene flow identifi medium level nm data suggest finless porpois may undergon histor differenti event finless porpois three region could divid two popul west eastsouth
|
D019576
|
T015
|
36,292,585
|
differenti methyl dna region left ventricular hypertrophi african american hypergen studi left ventricular lv hypertrophi lvh independ risk factor cardiovascular diseas african american experi dispar high risk lvh genet studi identifi potenti candid gene variant relat condit epigenet modif may continu help unravel diseas mechan use methyl echocardiographi data african american select hypertens genet epidemiolog network hypergen identifi differenti methyl region dmrs associ lvh dna extract whole blood assay illumina methyl array fit linear mix model examin associ co methyl region lv trait conduct singl cpg analys within signific dmrs identifi associ dmrs eject fraction xkr lv intern diastol dimens trak lv mass index gse rps psmd relat wall thick dnhd singl cpg analysi cpg site annot trak dnhd signific cpgs associ lv trait replic cohort direct effect dnhd consist across cohort note dnhd gse psmd may contribut cardiac structur function futur studi evalu relationship region dna methyl pattern develop lvh
|
D017379;D006973
|
T047
|
36,292,584
|
melatonin function crosstalk phytohormon normal stress condit melatonin discov plant late nineti role signal crosstalk phytohormon remain unknown research melatonin plant risen dramat recent year role putat plant hormon biotic abiot stress condit report present review discuss main function melatonin growth develop plant role abiot stress water stress waterlog drought extrem temperatur low high salin heavi metal light induc stress similar also discuss role melatonin biotic stress antivir antibacteri antifung effect moreov present review meticul discuss crosstalk melatonin phytohormon auxin gibberel acid cytokinin ethylen salicyl acid normal stress condit report melatonin receptor signal plant aspect melatonin suggest phytomelatonin key player crop improv biotic abiot stress regul
|
D010937;D008550
|
T125;T121;T116;T109
|
36,292,583
|
estim metabol effect upon cadmium exposur pregnanc use tensor decomposit simpl tensor decomposit model appli liver transcriptom analysi data elucid caus cadmium induc gene overexpress addit estim mechan prenat cd exposur disrupt insulin metabol offspr numer studi report toxic cd liver transcriptom analysi reveal cd toxic induc intracellular oxid stress mitochondri dysfunct via chang gene express turn induc endoplasm reticulum associ degrad via abnorm protein fold howev specif mechan under effect remain unknown studi found cd induc endoplasm reticulum stress may promot increas express tumor necrosi factor tnf base high express gene involv product sphingolipid also found accumul ceramid may induc intracellular oxid stress overproduct reactiv oxygen speci addit high express set gene involv electron transfer system may contribut oxid stress find allow us identifi mechan intracellular oxid stress lead phosphoryl insulin receptor substrat play signific role insulin signal pathway
|
D002104;D014409
|
T129;T131;T196;T116
|
36,292,582
|
grant motif regul cenp incorpor restrict rna polymeras ii access centromer precis chromosom segreg essenti maintain genom stabil proper execut center centromer chromosom locus mount kinetochor complex mediat attach chromosom spindl microtubul locat centromer epigenet determin centromer specif histon h variant cenp mani human cancer exhibit overexpress cenp correl occurr aneuploidi malign centromer target cenp depend histon fold recent studi show n termin tail domain ntd also play essenti role investig implic ntd confer aneuploidi format cenp overexpress fission yeast seri mutant gene progress lack one amino acid ntd construct overexpress wild type cell use intermedi strength nmt promot construct host disrupt grant genom stabil regul site within cenp n terminus motif ntd result growth retard aneuploidi increas local centromer upregul rna polymeras ii access transcript derepress repress centromer chromatin suggest grant residu fine tune centromer cenp incorpor restrict rna polymeras ii access work highlight import cenp ntd particular grant motif aneuploidi format overexpress cenp fission yeast
|
D006657;D012568
|
T123;T004;T116
|
36,292,581
|
chase consist updat tcp gene famili malus domestica member teosint branch cycloideaprolifer cell factor tcp transcript factor gene famili malus domestica domestica identifi first genom assembl releas higher qualiti genom assembl appl releas consid refer genom moreov sever speci identifi tcp gene name base relat posit gene chromosom present work consist updat tcp gene famili base latest genom assembl domestica compar previous classif number tcp gene decreas result addit three sequenc deduct analysi intragen ident led identif pair ortholog shed light forc shape evolut gene famili furthermor revis nomenclatur system propos base intragen ident homolog arabidopsi thaliana thaliana tcps effort set common standard tcp classif facilit futur interspecif analysi
|
D027845;D017360
|
T168;T002
|
36,292,580
|
genom wide analysi express profil voz gene famili quinoa chenopodium quinoa vascular plant one zinc finger voz protein plant specif transcript factor famili play import role plant develop stress respons howev littl known voz gene quinoa present studi genom wide investig voz gene famili quinoa perform includ gene structur conserv motif phylogeni express profil total four quinoa voz gene distribut three chromosom identifi base phylogenet analysi cqvoz cqvoz belong subfamili ii cqvoz cqvoz belong subfamili iii furthermor voz transcript factor quinoa sugarbeet close relat speci except cqvoz three cqvoz four exon four intron analysi conserv motif indic cqvoz member contain seven common motif multipl sequenc align show cqvoz gene high conserv consensus sequenc might plausibl signific preserv structur integr famili protein tissu express analysi reveal four cqvoz gene high express infloresc relat low leav stem suggest gene obvious tissu express specif express profil quinoa cqvoz various abiot stress demonstr gene differenti induc cold stress salt stress drought stress transcript level cqvoz cqvoz regul salt stress drought stress cqvoz cqvoz regul cold salt drought stress could use abiot stress resist candid gene studi systemat identifi cqvoz gene genom wide level contribut better understand quinoa voz transcript factor famili lay foundat explor molecular mechan develop stress resist quinoa
|
D027465
|
T168;T002
|
36,292,579
|
novel framework analysi share genet background correl trait propos novel effect framework analysi share genet background set genet correl trait use snp level gwas summari statist framework call shaher base construct linear combin trait maxim proport genet varianc explain share genet factor shaher requir full gwas summari statist matric genet phenotyp correl trait input framework allow share unshar genet factor effect analyz test framework use simul studi compar previous develop assess perform use three real dataset anthropometr trait psychiatr condit lipid concentr shaher versatil applic summari statist gwass arbitrari sampl size sampl overlap allow incorpor differ gwas model cox linear logist comput fast
|
D020641;D055106
|
T063;T086
|
36,292,578
|
identif hypomorph fancg variant bernes mountain dog bernes mountain dog bmds overal cancer incid half compris otherwis rare tumor histiocyt sarcoma hs recent studi identifi driver mutat mapk pathway identif key predispos gene elus studi identifi sever loci associ predisposit hs bmds includ near mtapcdkna region causat code variant identifi report presenc code polymorph gene encod fancg near mtapcdkna locus variant conserv region protein appear specif bmds canin fibroblast deriv dog homozyg variant hypersensit cisplatin show canin fancg variant previous defin hypomorph fancg allel human impart similar defect dna repair howev data also indic variant neither necessari suffici develop hs furthermor bmds homozyg fancg allel display none characterist phenotyp associ fanconi anemia fa anemia short statur infertil earlier age onset hs similar find fa defici mice develop overt fa without secondari genet mutat exacerb fa deficit sum data suggest dog deficit fa pathway like mice innat resist develop fa
|
D005199;D054747
|
T047;T191
|
36,292,577
|
increas risk hereditari prostat cancer italian famili hereditari breast ovarian cancer syndrom harbor mutat brca suscept gene hereditari prostat cancer hpca highest herit cancer men interest occur sever hereditari syndrom includ breast ovarian cancer hboc lynch syndrom ls sever gene mutat relat syndrom identifi biomark hpca goal studi screen germlin mutat suscept gene use multigen panel subsequ correl result clinic laboratori paramet undertaken hboc famili includ male prostat cancer pca mutat analysi extend famili member mutat patient screen hboc famili reveal harbor germlin mutat suscept gene harbor pathogen variant pvs variant uncertain signific vus found pvs similar frequenc brca brca gene respect pvs present well establish suscept gene palb tp radc moreov monoallel pvs present mutyh gene whose function tumorigenesi context pca still unclear final report doubl heterozygos dh brca gene singl famili found doubl mutat dm present brca separ famili signific differ mean age onset pca hboc famili without germlin mutat suscept gene mean surviv highest mutat patient compar wild type furthermor pca second recurr cancer cohort result case mutat non mutat famili investig show pvs locat most brca brca gene brca pvs fell exon suggest mutat cluster region relat risk hpca total famili member inherit proband mutat develop cancer remain unaffect
|
D061325;D011471
|
T191
|
36,292,576
|
compar phylogenet analys complet chloroplast genom scrophularia incisa complex scrophulariacea scrophularia incisa complex group close relat desert stepp subshrub includ incisa kiriloviana dentata sect canina compon found northwest china base earlier molecular evid speci boundari phylogenet relationship within complex remain poor resolv character seven complet chloroplast genom encompass repres three taxa complex one close relat speci integrifolia well three speci scrophularia compar genom analys indic genom structur gene order content high conserv among eleven plastom high variabl plastid region simpl sequenc repeat ssrs identifi robust consist phylogenet relationship incisa complex first construct base total plastid genom scrophulariacea within monophylet complex kiriloviana individu pamir plateau identifi earliest diverg clade follow dentata tibet remain individu kiriloviana tianshan mountain incisa qinghai gansu cluster sister clade result evid demonstr capabl plastid genom improv phylogenet resolut speci delimit particular among close relat speci promot understand plastom evolut scrophularia
|
D054628;D032266;D028083
|
T002;T028
|
36,292,575
|
whole exom sequenc reveal pathogen sirt variant brain arterioven malform case report arterioven malform brain bavm plexus patholog arteri vein lack normal capillari system intracrani hemorrhag hemorrhag stroke frequent clinic manifest avm lead lethal outcom especi high among children young peopl recent high throughput genom sequenc method made notabl contribut research progress subject particular whole exom sequenc wes method allow identif novel mutat howev genet mechan caus avm still unclear therefor aim studi investig potenti genet mechan under avm analyz wes data blood tissu sampl year old central asian male diagnos avm identifi polymorph gene silica overrepresent enrich analysi polymorph sirt gene variant gc amp gt indic possibl molecular mechan bavm studi requir evalu function impact sirt gc amp gt may warrant replic biolog investig relat sporad bavm
|
D056564;D002538
|
T019;T126;T116
|
36,292,574
|
review applic near infrar spectroscopi two rare disord execut neurolog dysfunct ucd pku studi rare diseas particular neurolog dysfunct challeng research healthcar profession due complex small popul geograph dispers univers standard biomark generat tool function neuroimag forg collect baselin data well treatment effect howev cost heavili infrastructur requir technolog substanti limit avail thus develop non invas portabl inexpens modal becom major focus research clinician consid neurolog disord diseas execut dysfunct eeg conveni tool obtain biomark correl object sever clinic observ condit howev studi also shown eeg biomark clinic observ alon sensit enough sinc patient present classic phenotyp featur eeg evid dysfunct articl review disord includ two rare disord neurolog dysfunct use function near infrar spectroscopi fnir non invas optic modal obtain hemodynam biomark diseas screen monitor diseas
|
D019265;D035583
|
T047;T059
|
36,292,573
|
develop valid mps base system human appear predict challeng forens sampl forens dna phenotyp fdp provid abil predict human extern trait unknown sampl donor direct minut amount dna found crime scene develop mps multiplex assay aim genotyp dna marker includ hirisplex system simultan predict eye hair skin colour forens sampl blood skelet remain touch dna saliva swab artifici degrad sampl togeth individu known phenotyp set control dna sequenc ion torrent platform order evalu concord test result forens suitabl plex mps assay panel evalu test differ number pcr cycl volum reagent librari prepar studi demonstr full reliabl profil obtain ng even high degrad dna increment number pcr cycl result improv correct genotyp phenotyp sampl low amount degrad dna higher frequenc artefact found high dna degrad level influenc correct genotyp phenotyp critic paramet affect result quantiti input dna eye hair colour predict individu skin colour individu result suggest mps assay robust high sensit use human pigment predict forens genet field
|
D005127;D020641
|
T032;T086
|
36,292,572
|
missens variant gfra npnt associ congenit anomali kidney urinari tract use next generat sequenc ngs help identifi mani gene caus congenit anomali kidney urinari tract cakut bilater renal agenesi bra sever present cakut associ autosom recess inherit gene expand high consanguin popul impact detect recess inherit gene report two famili harbor homozyg missens variant recent describ gene npnt gfra two consanguin famili neonat death due cakut investig fetal ultrasound proband identifi bra first famili sever renal cystic dysplasia second famili exom sequenc coupl homozygos map perform sanger sequenc use confirm segreg allel famili first famili bra identifi homozyg missens variant gfra ca amp gt g p tyrci predict damag protein structur second famili renal cystic dysplasia identifi homozyg missens variant npnt cc amp gt g p alag predict disrupt signal peptid site report two saudi arabian consanguin famili cakut phenotyp includ renal agenesi caus missens variant gfra npnt confirm role two gene human kidney develop
|
D014551
|
T023
|
36,292,571
|
identif two novel epor gene variant primari famili polycythemia case report literatur review primari famili congenit polycythemia rare diseas character increas red cell mass may due pathogen variant epo receptor epor gene date genet variant report associ analyz presenc epor variant two patient polycythemia jak pathogen variant previous discard molecular analysi epor gene perform sanger sequenc code region exonintron boundari exon perform vitro cultur erythroid progenitor cell segreg studi done whenev possibl two patient studi show hypersensit epo vitro cultur analysi epor gene unveil two novel pathogen variant genet test asymptomat relat could guarante surveil proper manag
|
D017467;D011086
|
T033;T047;T116;T192
|
36,292,570
|
paleogenom reveal complex evolutionari histori late pleistocen bison northeastern china stepp bison typic repres mid late pleistocen stepp northern hemispher despit abund fossil remain mani question relat genet divers popul structur dispers rout still elus present near complet partial mitochondri genom well partial nuclear genom fossil bison sampl excav late pleistocen strata northeastern china maximum likelihood bayesian tree suggest bison clade divid three matern haplogroup b c chines individu fall two bayesian analysi show split haplogroup c ancestor haplogroup b date ky bp hpd ky bp addit nuclear phylogenom tree also support basal posit individu carri haplogroup c admixtur analys suggest cadg haplogroup c similar genet structur stepp bison siberia haplogroup b new find indic genet divers pleistocen bison probabl even higher previous thought northeastern chines popul sever mammalian speci includ pleistocen bison genet distinct
|
D016164;D054629
|
T015;T028
|
36,292,569
|
genet dysrupt histaminerg pathway novel delet q locus associ variabl express neuropsychiatr disord involv histaminerg system hs neuropsychiatr diseas well document studi describ patient affect differ neuropsychiatr condit harbour disrupt gene involv hs human histamin synthetis histidin histidin decarboxylas enzym encod hdc gene omim sole enzym organ abl synthetis histamin histidin histamin also contain mani differ food type herebi describ twenti one year old femal diagnos borderlin intellectu disabl autist trait peculiar neuropsycholog featur carri kb interstiti delet chromosom q delet inherit mother affect sever anxieti disord delet region contain entir hdc slca gene partial atpb gene hdc gene previous associ tourett syndrom ts base function role hdc propos gene best candid explain mani trait associ clinic phenotyp patient mother
|
D006640;D005879
|
T047;T126;T116
|
36,292,568
|
popul genet data insert delet marker polish popul background insert delet indel marker show advantag short tandem repeat strs singl nucleotid polymorph snps consid altern marker forens genet method allel frequenc correspond forens effici paramet autosom polymorph indel loci includ investig dipplex kit qiagen obtain sampl unrel polish individu allel frequenc data compar report select popul result loci conform hardi weinberg equilibrium appli bonferroni correct pair wise signific linkag disequilibrium detect conclus dipplex kit differ high among popul worldwid indel marker high discrimin human identif purpos polish popul
|
D005828;D054643
|
T045;T090
|
36,292,567
|
genom wide investig character sweet gene famili focus evolut express hormon abiot stress respons maiz sugar eventu export transport sweet famili import group transport carrier carbon partit plant import function growth develop abiot stress toler although sweet famili import sugar transport littl known function sweet famili maiz zea may especi respons abiot stress explor respons pattern maiz sweet abiot stress bioinformat base approach use predict identifi maiz sweet gene zmsweet famili twenti four zmsweet gene identifi use maizegdb databas phylogenet analysi resolv twenti four gene four clade one tandem five segment duplic event identifi play major role zmsweet famili expans synteni analysi provid insight evolutionari characterist zmsweet gene three graminac crop speci heatmap show zmsweet gene respond least one type abiot stress abscis acid signal pathway among five gene signific induc nacl treatment eight obvious regul peg treatment five regul cd stress reveal potenti function respons abiot stress find help explain evolutionari link zmsweet famili contribut futur studi function characterist zmsweet gene improv abiot stress toler maiz molecular breed
|
D003313;D018506
|
T045;T168;T002
|
36,292,566
|
crisprca mediat gene edit bnfad bnfae modifi fatti acid profil brassica napus fatti acid fa composit determin qualiti oil oilse crop thus major target genet improv fad fatti acid dehydrogenas fae fatti acid elongas critic fa synthet gene focus genet manipul alter fatti acid composit oilse plant studi improv nutrit qualiti rapese cultivar cy oil content eruc acid generat novel knockout plant crisprca mediat genom edit bnfad bnfae gene two guid rnas design target one copi bnfad gene two copi bnfae gene respect number line mutat three target site bnfad bnfae gene identifi sequenc analysi three line show mutat three target site bnfad bnfae gene fatti acid composit analysi seed reveal mutat three site result signific increas oleic acid content compar cy great reduc eruc acid level slight decreas polyunsatur fatti acid content result confirm crisprca system effect tool improv import trait
|
D029688
|
T168;T002
|
36,292,565
|
character crh bind protein crhbp chicken molecular clone tissu distribut investig role negat feedback regul within hypothalamus pituitari adren axi corticotropin acth pituitari hormon play import role stress respons within hypothalamus pituitari adren hpa axi biosynthesi secret acth control multipl factor includ corticotropin releas hormon crh key hypothalamus deriv regul crh bind corticotropin releas hormon receptor crhr anterior pituitari gland regul acth synthesi releas thus crh bind protein crhbp bind crh high affin inhibit crh induc acth secret pituitari cell draw wide attent contrast extens investig crhbp mammal lower vertebr gene structur tissu express physiolog function crhbp bird remain larg unknown present studi use chicken c anim model examin gene structur tissu express function crhbp result show ccrhbp cdna encod amino acid precursor share high sequenc ident mammal reptil frog fish ccrhbp abund express brain cerebrum hypothalamus pituitari ovari ccrhbp inhibit signal ccrhrs induc ccrh thus reduc ccrh induc acth secret cultur chick pituitari cell stress mediat eg glucocorticoid stress signific upregul crhbp mrna express chicken support role negat feedback regul hpa axi present studi enrich understand conserv role crhbp across vertebr addit chicken import poultri anim multipl econom trait tight control hpa axi character chicken crhbp gene help reveal molecular basi chicken hpa axi thus benefici poultri industri
|
D010913;D007030
|
T022;T030
|
36,292,564
|
nois reduct sensit enhanc sleep beauti base tet system tetracyclin induc system wide use control element mammalian gene express despit multipl iter improv induc use still compromis basal promot activ absenc tetracyclin mammalian system previous show introduct gv mutat rtta tetracyclin activ lower basal level express increas fold induct multipl genet element long chimer antigen receptor construct studi confirm gv mutat effect minimis background express absenc induc result increas fold express loss respons due gv mutat compens incorpor four sensit enhanc se mutat without compromis promot tight howev se mutat alon without gv led undesir leaki although cryptic splice site remov rtta alter induc control luciferas report gene simplifi vector system still recommend precaut complex multi gene element contain rtta optim express construct contain gv se mutat current provid best improv fold induct mediat rtta activ mammalian system
|
D013752;D000076962
|
T129;T116;T192;T109;T195
|
36,291,751
|
cholesterol content low densiti lipoprotein associ year mortal acut heart failur patient consid relationship extent metabol derang diseas sever heart failur hypothes lipid content low densiti lipoprotein vldl may prognost valu year mortal acut heart failur ahf baselin serum level vldl cholesterol vldl c vldl triglycerid vldl tg vldl phospholipid vldl pl vldl apolipoprotein b vldl apob measur use nmr spectroscopi calcul ratio respect vldl lipid vldl apob vldl cvldl apob vldl tgvldl apob vldl plvldl apob estim cholesterol triglycerid phospholipid content vldl particl test associ mortal ahf patient patient die within year hospit ahf univari cox regress analys reveal signific invers associ vldl cvldl apob hazard ratio hr confid interv ci p amp lt vldl tgvldl apob hr ci p amp lt vldl plvldl apob hr ci p amp lt year mortal test paramet vldl cvldl apob remain signific adjust age sex well clinic laboratori paramet show signific associ year mortal univari analys conclud cholesterol content circul vldl vldl cvldl apob might prognost valu ahf
|
D008079;D006333
|
T123;T047;T046;T116
|
36,291,750
|
type interferon receptor subunit delet attenu experiment abdomin aortic aneurysm format type interferon receptor signal contribut sever autoimmun vascular diseas lupus atherosclerosi stroke purpos studi assess influenc type interferon receptor defici format progress experiment abdomin aortic aneurysm aaa
|
D017544
|
T047
|
36,291,749
|
new betulin deriv nitrogen heterocycl moieti synthesi anticanc activ vitro part search new medicin substanc potenti applic oncolog synthesi new compound combin betulin molecul indol system carri structur ester deriv obtain steglich reaction confirm spectroscop method h c nmr hr ms obtain new indolyl betulin deriv evalu anticanc activ sever human cancer cell line melanoma breast cancer colorect adenocarcinoma lung cancer well normal human fibroblast signific reduct mcf cell viabil hydroxi lup ene yl h indol yl acet observ concentr gml addit cytometr analysi show compound strong reduc prolifer rate breast cancer cell deriv show promis cytotox effect mcf breast cancer cell pharmacokinet profil predict perform use silico method base result obtain studi conclud indol function triterpen eb promis start point research field breast cancer therapi synthesi new deriv
|
D014315;D000970;D001943
|
T121;T191;T109
|
36,291,748
|
automat cell type annot use marker gene singl cell rna sequenc data recent advanc singl cell rna sequenc scrna seq technolog gain attent cell type annot play essenti role scrna seq data analysi sever comput method propos automat annot tradit cell type annot first cluster cell use unsupervis learn method base gene express profil label cluster use aggreg cluster level express profil marker gene inform procedur reli heavili cluster result puriti cluster guarante fals detect cluster featur may lead wrong annot paper improv procedur propos automat cell type annot method acam acam delin clear framework conduct automat cell annot repres cluster identif repres cluster annot use marker gene remain cell classif experi seven real dataset show better perform acam compar six well known cell type annot method
|
D059010;D059467
|
T081;T059;T086
|
36,291,747
|
heat shock protein upregul supplement complex mrna alter autoimmun glaucoma glaucomat optic neuropathi common caus blind elev intraocular pressur main risk factor also contribut immun system seem like experiment autoimmun glaucoma model use system immun optic nerv homogen antigen ona lead retin ganglion cell rgc optic nerv degener process retina quantit real time pcr immunohistolog day immun furthermor perform mrna profil model first time detect signific rgc loss ona retina accompani upregul mrna express gene belong heat shock protein famili furthermor mrna express level gene immun system cqa cqb il nfkb upregul ona anim laser microdissect inner retin layer use mrna microarray nine probe signific upregul ona anim p amp lt includ hba cxcl fifteen probe signific downregul ona anim p amp lt gdf wwox taken togeth find provid insight pivot role immun respons glaucomat optic neuropathi could help identifi novel diagnost therapeut strategi
|
D005901;D009901
|
T047
|
36,291,746
|
gerstmann strussler scheinker diseas fs mutat induc independ tau prion protein patholog bank vole gerstmann strussler scheinker diseas gss rare genet prion diseas larg gss kindr link serin phenylalanin substitut codon prion protein gene gss fs character conspicu accumul prion protein prp amyloid deposit neurofibrillari tangl recent demonstr transmiss gss fs prion bank vole carri isoleucin prp codon bvi investig transmiss gss fs prion vole carri methionin codon bvm ii induct hyperphosphoryl tau ptau two vole line iii compar phenotyp gss fs induc ptau ptau induc bvm follow intracerebr inocul famili alzheim diseas case carri presenilin mutat fad ps detect prion transmiss bvm despit high suscept bvi previous observ immunohistochemistri establish presenc induc ptau deposit vole brain affect prion furthermor phenotyp ptau deposit vole brain similar gss fs fad ps overal result suggest regardless caus ptau deposit relationship prpsc gss fs human affect brain two compon possess seed properti ptau deposit similar induc gss fs fad ps
|
D016098;D011328
|
T047;T005;T116
|
36,291,745
|
aortic aneurysm dissect heterogen molecular mechan aortic aneurysm dissect aad devast aortic diseas high risk aortic ruptur lead uncontrol bleed death
|
D017545;D000784;D001014
|
T047;T046
|
36,291,744
|
effect psychotrop medic somat sterol biosynthesi adult mice polypharmaci common use treat psychiatr disord combin often includ drug sterol biosynthesi inhibit side effect includ antipsychot aripiprazol ari antidepress trazodon trz effect psychotrop medic poor understood across various tissu type date investig effect ari trz ari trz polypharmaci post lanosterol biosynthesi three cell line neuroa hepg human dermal fibroblast seven peripher tissu adult mous model found ari trz strong interfer function dehydrocholesterol reductas enzym dhcr lead robust elev dehydrocholesterol level dhc reduct desmosterol des across cell line somat tissu ari trz co administr result summat synergist effect across util vitro vivo model find suggest least side effect ari trz receptor mediat aris inhibit dhcr enzym activ propos interfer sterol biosynthesi particular case simultan util medic side effect potenti interfer function develop multipl organ system warrant investig
|
D014150;D014196
|
T121;T039;T109
|
36,291,743
|
model hyperglycaemia epitheli membran model biophys characteris biomimet model valuabl platform improv knowledg molecular mechan govern membran driven process patho physiolog condit includ membran permeabl transport fusion howev current membran model simplist includ membran lipid remodel respons extracellular stimuli studi describ synthesi glycat dimyristoyl phosphatidylethanolamin dmpe glyc structur characteris mass spectrometri esi ms quantifi nmr spectroscopi incorpor complex phospholipid pl membran model enrich cholesterol chol glyco sphingolipid gsl design mimic epitheli membran plcholgsl hyperglycaemia condit characteris synthesis dmpe glyc adduct tandem mass spectrometri esi msms show synthet dmpe glyc adduct correspond amadori product quantif h nmr spectroscopi show yield glycat reaction biophys characteris epitheli membran model show excess glucos alter thermotrop behaviour fluiditi epitheli membran model like impact permeabl solut epitheli membran model develop mimic normo hyperglycaem scenario basi investig poli phenol lipid drug membran interact crucial nutrit pharmaceut structur biochemistri medicin chemistri
|
D006943;D010714
|
T033;T123;T047;T109
|
36,291,742
|
molecular classif gene associ hypox lipid metabol pancreat cancer abnorm lipid metabol often occur hypox microenviron import energi supplement cancer cell prolifer metastasi aim explor lipid metabol characterist gene express featur pancreat ductal adenocarcinoma pdac relat hypoxia identifi biomark molecular classif base hypox lipid metabol evalu pdac prognosi therapi multipl dataset analyz integr includ correspond clinic inform sampl pdac possess distinct metabol profil oxygen level compar normal pancreat tissu accord bioinformat method addit studi untarget metabolom use ultra perform liquid chromatographi tandem mass spectrometri uplc ms reveal lipid metabolit differ affect oxygen analysi pdac gene express profil cancer genom atlas tcga reveal sphingolipid process correl close hif accord charact hif sphingolipid sampl cluster three subgroup use non negat matrix factor cluster cluster patient increas surviv time relat high muc mutat aris cluster may posit influenc cancer surviv rate studi explor express pattern lipid metabol hypoxia microenviron pdac basi metabol signatur identifi prognosi subtyp link lipid metabol hypoxia classif may conduc develop person treatment program target metabol profil
|
D010190;D021441
|
T191
|
36,291,741
|
mitochondri dysfunct high intraocular pressur induc retin ischemia minipig model purpos retin ischemia ri progress neuron death sight threaten condit mitochondri mt dysfunct fusionfiss process suggest play role pathophysiolog ri studi focus chang mt paramet neuroretina retin pigment epithelium rpe choroid porcin high intraocular pressur iop induc ri minipig model method one eye acut iop elev induc minipig compar control eye activ amount respiratori chain complex rcc analyz spectrophotometri western blot respect coenzym q coq content measur use hplc ultrastructur mt studi via transmiss electron microscopi express select mt pathway gene determin rt pcr result function level increas rcc activ decreas total coq content found rpe cell protein level core subunit rcc iii drp signific decreas neuroretina drp opa protein encod gene respons mt qualiti control decreas sampl rpe neuroretina conclus eye minipig consid potenti ri model studi mt dysfunct diseas strategi target mt protect may provid promis way delay acut damag onset ri
|
D002292;D005901;D007680
|
T047;T191
|
36,291,740
|
molecular regul heme oxygenas express ef transcript factor lung fibroblast cell relev idiopath pulmonari fibrosi idiopath pulmonari fibrosi ipf fatal chronic lung diseas heme oxygenas hmoxho enzym catalyz degrad heme role ho pathogenesi ipf studi howev molecular regul ho role ipf still unclear studi found ho protein level signific increas lung myofibroblast ipf patient lung murin model bleomycin induc lung fibrosi addit observ administr ef transcript factor inhibitor elev ho mrna protein level lung fibroblast downregul ef sirna transfect increas ho mrna protein level overexpress ef reduc ho level howev overexpress ef alter hemin induc ho protein level furthermor modul ho level regul tgf induc myofibroblast differenti without alter phosphoryl smad lung fibroblast cell moreov phosphoryl protein kinas b akt signific upregul ho deplet lung fibroblast cell summari studi demonstr ef regul baselin express ho effect modul ho express hemin final elev ho express contribut tgf induc lung myofibroblast differenti activ serinethreonin kinas akt pathway overal find suggest target efho might new therapeut strategi treat fibrot diseas ipf
|
D054990
|
T047
|
36,291,739
|
ep pred machin learn tool bioprospect promiscu ester hydrolas bioprospect novel industri enzym substrat promiscu desir properti increas reusabl enzym among industri enzym ester hydrolas great relev demand ceas increas howev search new substrat promiscu ester hydrolas trivial sinc mechan behind properti great influenc activ site structur physicochem characterist characterist must comput structur rare avail expens measur henc need method predict promiscu sequenc alon report method call ep pred ensembl binari classifi combin three machin learn algorithm svm knn linear model ep pred evalu lipas engin databas togeth hidden markov approach lead final set ten sequenc predict encod promiscu esteras experiment result confirm valid method sinc ten protein found exhibit broad substrat ambigu
|
D065132;D004950
|
T062;T126;T116
|
36,291,738
|
advanc molecular biomark cardiolog cardiovascular diseas cvd repres lead caus death world despit innov therapi advanc general manag patient
|
D002309;D002318
|
T047;T091
|
36,291,737
|
acyl n methylserotonin branch chain acylserotonin lemon citrus seed new lipid antioxid properti potenti pharmacolog applic found previous unknown compound seed lemon citrus speci tangerin grapefruit pomelo structur compound character hr ms spectrometri fluoresc spectroscopi chemic synthesi compound predomin long chain c c satur acyl n methylserotonin main contribut c c homologu usual account acylserotonin respect previous undescrib minor compound branch chain acylserotonin well normal chain acylserotonin recent found baobab seed oil within seed acylserotonin found near exclus inner seed coat probabl biosynthesi proceed hand lemon seedl contain trace amount compound found adult leav compound identifi present studi shown antioxid properti vitro use diphenyl picrylhydrazyl dpph assay investig reaction hexan c c serotonin less activ n c n c serotonin tocopherol branch chain acylserotonin iso c c show higher antioxid activ normal chain compound hand compound show similar consider lower antioxid activ acetonitril hexan
|
D002957
|
T168;T002
|
36,291,736
|
epigenet dimens protein structur intrins weak alphafold program one import lesson learn sequenc human genom protein structur fact larg part human proteom made intrins disord protein idp adopt multipl structur therefor multipl function depend ligand interact condit one wonder valu algorithm develop predict structur protein particular alphafold ai claim solv problem protein structur recent studi highlight particular weak alphafold membran protein base observ propos paradigm refer epigenet dimens protein structur edp take account environment paramet control structur protein beyond amino acid sequenc henc epigenet new studi compar reliabl alphafold robetta algorithm predict new set membran protein involv human patholog found robetta general accur alphafold ascrib membran compat topolog raft lipid eg gangliosid control structur dynam membran protein structur chaperon effect identifi major actor edp paradigm conclud epigenet dimens protein structur intrins weak ai base protein structur predict especi alphafold warrant develop
|
D064267
|
T123;T116
|
36,291,735
|
tnp analogu inhibit virul promot ip kinas arg fungal pathogen cryptococcus neoforman new antifung uniqu mode action urgent need treat increas global burden invas fungal infect fungal inositol polyphosph kinas ipk pathway compris ipk convert ip ip provid promis new target due impact multipl critic cellular function unlik mammalian cell lack redund near ipk fungal pathway essenti virul ip kinas ip k critic dibenzylaminopurin compound n trifluorobenzylamino n p nitrobenzylamino purin tnp commerci avail inhibitor mammalian ipk abil tnp adapt inhibitor fungal ip k investig purifi ip k human pathogen cryptococcus neoforman candida albican optimis enzym surfac plasmon reson spr assay determin half inhibitori concentr ic bind affin kd respect tnp analogu novel chemic rout develop effici prepar tnp analogu tnp analogu demonstr inhibit recombin ip k c neoforman cnarg low ic ip k c albican caipk mani analogu exhibit select cnarg human equival hsipmk result provid foundat improv potenc select tnp seri fungal ip k
|
D003455;D003453
|
T047;T004
|
36,291,734
|
cyclosporin deliveri platform veterinari ophthalmolog new concept advanc ophthalmolog cyclosporin csa select revers immunosuppress agent wide use medic wide spectrum diseas human graft versus host diseas non infecti uveiti rheumatoid arthriti psoriasi atop dermat furthermor csa use treat keratoconjunct sicca chronic superfici kerat immun mediat kerat equin recurr uveiti anim select activ cyclosporin csa demonstr immunomodul characterist lymphocyt prolifer inhibit cytokin gene express moreov lipophil characterist poor bioavail low solubl water besid side effect forc need develop new formul devic provid adequ penetr anterior posterior segment eye review aim summar effect safeti cyclosporin deliveri platform veterinari ophthalmolog
|
D009885;D014605;D007634
|
T047;T091
|
36,291,733
|
smn physiolog downregul wild type motor nerv termin aggreg togeth neurofila sma mous model surviv motor neuron smn essenti ubiquit express protein particip sever aspect rna metabol smn defici caus devast motor neuron diseas call spinal muscular atrophi sma smn form core protein complex local cytoplasm nuclear gem catalyz spliceosom snrnp particl synthesi cultur motor neuron smn also present dendrit axon form part ribonucleoprotein transport granul implic mrna traffick local translat nevertheless distribut regul role smn axon presynapt motor termin vivo still unclear use convent confoc microscopi sted super resolut nanoscopi found smn appear form granul distribut along motor axon nerv termin fluoresc situ hybrid electron microscopi studi also confirm presenc actin mrna ribosom polysom presynapt motor termin key element protein synthesi machineri involv local translat compart smn granul co local microtubul associ protein b mapb neurofila suggest cytoskeleton particip transport posit granul also found smn granul physiolog downregul presynapt element period postnat matur wild type non transgen mice accumul area neurofila aggreg sma mice suggest high express smn nmj togeth cytoskelet defect contribut impair bi direct traffic protein organell axon presynapt termin
|
D007382;D009134
|
T026;T047
|
36,291,732
|
synthesi protein oligonucleotid conjug nucleic acid protein form two key class function biomolecul abil access specif protein oligonucleotid conjug broader rang function molecul becom access leverag programm recognit potenti nucleic acid structur chemic function divers protein herein summar avail conjug strategi access chimer molecul highlight key case studi exampl within field showcas power util technolog
|
D009841;D009696
|
T123;T114
|
36,291,731
|
grape pulp fiber possibl fine agent red wine one biggest problem use tradit fine agent present allergen characterist suitabl vegan consum due anim origin altern tradit proteinac agent could cell wall grape pulp materi could use modifi final phenol concentr wine due affin phenol compound studi abil freez dri grape pulp fiber rich pulp cell wall act fine agent analyz wine three differ varieti cabernet sauvignon syrah monastrel use materi wine chromat characterist total tannin concentr analyz spectrophotometr chromatograph techniqu addit wine contamin ochratoxin histamin check whether materi could also tool remov wine contamin pulp fiber present high capac retain phenol compound especi tannin howev differ depend studi wine largest reduct tannin concentr fine observ materi use cabernet sauvignon wine wherea monastrel wine reduct lower even lower syrah wine fine agent also reduc anthocyanin concentr three red wine although lesser extent reduct observ tannin realli interest result addit fine agent reduc concentr ochratoxin studi wine
|
D027843
|
T129;T168;T116;T002
|
36,291,730
|
zebrafish model sever combin immunodefici scid due jak mutat jak princip activ member interleukin receptor famili play essenti role lymphoid develop inactiv jak mutat caus autosom recess sever combin immunodefici scid studi aim generat equival zebrafish model scid character model across life cours genom edit zebrafish jak creat mutant similar observ human scid homozyg jak mutant show reduc embryon lymphopoiesi continu larval stage adulthood b cell matur adult nk cell also reduc neutrophil impact mutant fish suscept lymphoid leukemia model mani hallmark human scid result inactiv jak mutat use varieti pre clinic applic
|
D016511
|
T047
|
36,291,729
|
method radiolabel nanoparticl spect use part use nanoparticl nps rapid increas nuclear medicin nm diagnost therapeut purpos wide use due chemic physic characterist possibl deliv sever molecul nps synthetis organ andor inorgan materi differ size shape chemic composit charg factor influenc biodistribut clearanc target abil vivo nps design encapsul insid core bind surfac sever molecul includ radionuclid differ clinic applic either diagnost therapeut radioact nps synthetis make call theragnost tool date sever method radiolabel nps vari depend physic chemic properti nps isotop use review analys compar differ method radiolabel nps singl photon emiss comput tomographi spect use
|
D053758
|
T073
|
36,291,728
|
copper depend kinas role cancer incept progress metastasi recent year copper function expand beyond consolid role cofactor enzym catalysi recent paper demonstr new dynam role copper regul cell signal pathway direct interact protein kinas modul activ activ pathway exacerb cancer cell sustain differ step tumor growth dissemin review focus novel propos role transit metal copper regul cell signal pathway direct interact known protein kinas exhibit bind domain metal activ pathway cancer cell support tumor growth dissemin addit descript result recent report literatur subject relev given possibl control cellular level copper homeostat regul overal find may central relev order propos copper homeostat regul possibl target novel therapi may act synergist alreadi exist control cancer growth dissemin
|
D003300;D009369
|
T123;T196;T121;T191
|
36,291,727
|
promis candid tendon heal event pdgf bb tendon injuri one common musculoskelet disord patient seek medic aid reduc qualiti life patient also impos signific econom burden societi administr growth factor wound site feasibl solut enhanc tendon heal platelet deriv growth factor bb pdgf bb well defin safeti profil compar growth factor approv food drug administr fda purpos review summar role pdgf bb tendon heal comprehens review publish literatur experiment studi suggest pdgf bb posit effect tendon heal enhanc inflammatori respons speed angiogenesi stimul tendon cell prolifer increas collagen synthesi increas biomechan repair tendon pdgf bb regard promis candid tendon heal howev order realiz full potenti still need care consid studi key issu dose applic time futur explor applic pdgf bb tendon heal process
|
D011788;D013710
|
T078;T023
|
36,291,726
|
method radiolabel nanoparticl pet use part use radiolabel nanoparticl nps promis nuclear medicin tool diagnost therapeut purpos thank heterogen materi organ inorgan uniqu physic chemic characterist high versatil use sever medic applic particular shown interest result radiolabel probe positron emiss tomographi pet imag high variabl np type possibl use sever isotop radiolabel process impli differ radiolabel method appli previous year review compar summar differ method np radiolabel frequent use pet isotop
|
D049268;D053758
|
T060;T073
|
36,291,725
|
ligand promot surfac solubil tio nanoparticl enterobactin siderophor biolog medium titanium dioxid nanoparticl tio nps increas use consum product particular properti even though tio consid chemic stabl insolubl studi behavior biolog environ great import figur potenti dissolut transform interact tio nps differ size crystallograph form anatas rutil strong chelat enterobactin ent siderophor investig look possibl dissolut first time direct evid anatas tio np surfac dissolut solubil ie remov ti atom locat surfac biolog medium siderophor shown progress format hexacoordin titanium enterobactin ti ent complex observ complex character uv visibl fourier transform infrar ftir spectroscopi support densiti function theori calcul well electrospray ionize mass spectrometri esi ms x ray photoelectron spectroscopi xps maximum ca ti surfac atom found solubil h incub releas ti ent complex micromolar rang could taken bacteria iron deplet medium health environment point view effect associ solubil e tio food addit presenc enterobactin entranc ti enterobactin complex bacteria question
|
D014025;D053758
|
T196;T073
|
36,291,724
|
streptococcus mutan affect surfac topographi electrochem behavior nanostructur bulk ti metabol carbohydr streptococcus mutan lead format lactic acid oral caviti consequ acceler degrad dental implant fabric commerci avail microcrystallin ti microstructur influenc surfac topographi henc interact bacteria cell ti surfac work offer first descript effect mutan surfac topographi properti nanostructur bulk ti promis candid modern narrow dental implant owe superior mechan strength found mutan incub result slight unexpect decreas surfac nanorough previous develop owe privileg oxid area close space boundari howev despit chang nanoscal surfac topographi bacteria incub reduc high level protect afford oxid layer form nanostructur ti surfac result highlight need hitherto ignor consid ti microstructur analyz behavior presenc carbohydr metabol bacteria
|
D013295;D015921
|
T007;T074
|
36,291,723
|
amygdalin review characterist antioxid potenti gastrointestin microbiota intervent anticanc therapeut mechan toxic encapsul bioactiv amygdalin found high concentr bitter almond recogn symbol cyanogen glycosid chemic organ substanc initi develop pharmaceut treat cancer hydrolyz hydrogen cyanid hcn regrett research shown hcn also damag normal cell render non toxic human bodi extrem controversi surround vivo vitro studi make use riski review provid extens updat characterist antioxid potenti gastrointestin microbiota intervent anticanc therapeut mechan toxic encapsul amygdalin antioxid anti tumor anti fibrot antiatherosclerosi anti inflammatori immunomodulatori analges characterist abil improv digest reproduct system neurodegener cardiac hypertrophi benefit amygdalin studi verifi hcn produc amygdalin harm oral high dose although intraven treatment less effect oral method oral rout dose rang g daili amygdalin toxic depend heavili varieti bacteria digest tract unfortun current foolproof method determin microbi consortium provid safe oral dosag everi patient amygdalin encapsul algin chitosan nanoparticl acnp relat new area research amygdalin enhanc cytotox effect malign cell acnp employ activ drug deliveri system releas compound regul sustain manner without caus harm healthi cell tissu conclus larg area research substanc might next step cancer therapi open due unverifi conflict data
|
D000678;D000069196;D048271;D009369
|
T121;T007;T109;T191;T001
|
36,291,722
|
antidepress drug sertralin human cancer cell use fda approv drug new indic repres faster econom way find novel therapeut agent cancer therapi compar develop new drug repurpos drug advantag pharmacolog context sinc drug alreadi extens data relat pharmacokinet facilit approv process differ diseas sever studi report promis anticanc effect sertralin alon combin differ type cancer cell line perform literatur review anticanc potenti sertralin differ human cancer cell specif lung colorect breast hepatocellular leukemia brain skin oral ovarian prostat cancer taken togeth find suggest sertralin decreas cell viabil prolifer migrat invas induc apoptosi caus cell cycl arrest differ type cancer cell besid establish p glycoprotein modul also found drug abl modul autophagi caus dna fragment induc radic oxygen speci ros format moreov found drug target import cellular pathway involv tumorigenes tnf mapk jnk pathway antiapoptot pathway pikaktmtor ampkmtor axi drug also interfer tctpp feedback loop cytosol free ca level togeth result suggest sertralin may promis compound evalu novel cancer therapi
|
D020280;D009369
|
T121;T191;T109
|
36,291,721
|
cardioprotect mechan leonurin myocardi ischemia liver cardiac crosstalk metabolom studi leonurin shown excel anti myocardi ischemia effect previous studi suggest cardiac protect leonurin myocardi ischemia appear inextric link regul liver present howev mechanist studi leonurin regul hepat metabol ischem injuri studi metabolom approach develop give global view metabol profil heart liver myocardi ischemia princip compon analysi orthogon partial least squar discrimin analysi appli filter differenti metabolit debias spars partial correl analysi use analyz correl differenti metabolit heart liver result total thirti one differenti metabolit identifi six myocardi tissu twenti five hepat tissu involv multipl metabol pathway includ glycin serin threonin purin fatti acid amino acid metabol pathway correl analysi reveal net differenti metabolit suggest interact hepat myocardi metabol result suggest leonurin may reduc myocardi injuri myocardi ischemia regul metabol glycin serin threonin purin fatti acid amino acid liver heart
|
D003324;D017202
|
T047
|
36,291,720
|
pten protein phosphatas activ requir tumour suppress mous prostat loss pten function one common event drive aggress prostat cancer biochem pten lipid phosphatas oppos activ oncogen pik akt signal network howev pten also addit potenti mechan action includ protein phosphatas activ use mutant enzym pten yl select lack protein phosphatas activ characteris genet modifi mice lack either full function pten prostat gland lack protein phosphatas activ phenotyp mice carri singl allel either wild type pten ptenyl prostat similar common prostat intraepitheli neoplasia pin similar gene express profil howev latter group lack pten protein phosphatas activ addit show lymphocyt infiltr around pin increas immun cell gene express signatur prostat adenocarcinoma elev prolifer akt activ frequent observ pten fulli delet also identifi common gene express signatur pten loss conserv studi includ nkx tnf cd provid insight tumour develop prostat driven loss pten function show pten protein phosphatas activ requir tumour suppress
|
D011471;D051059
|
T191;T126;T116
|
36,291,719
|
effect posit charg distribut cryoprotect activ dehydrin dehydrin intrins disord protein express ubiquit throughout plant kingdom respons desicc dehydrin found cryoprotect effect lactat dehydrogenas ldh vitro larg part influenc hydrodynam radius rather order amino acid within sequenc altern may sequenc specif effect howev seem differ mechan may underpin cryoprotect confer cold labil yeast frataxin homolog yfh circular dichroism spectroscopi cd use assess degre helic yfh c alon presenc sever dehydrin construct three construct compar wild type ysk kr lysin residu substitut arginin ysk neutral local neutral charg ysk spacek even distribut posit charg result show sequenc rearrang minor substitut littl impact abil dehydrin preserv ldh activ howev posit charg dehydrin local neutral even distribut dehydrin becom less effici promot structur yfh low temperatur suggest stabil charg base interact occur dehydrin yfh dehydrin intrins disord protein express certain organ improv desicc toler protein thought serv mani cellular role stabil membran dna protein howev molecular mechan under function dehydrin well understood examin import posit charg dehydrin sequenc make substitut compar effect cryoprotect two differ protein
|
D064267
|
T123;T116
|
36,291,718
|
isol character hydroxi trimethyl oxo cyclohexen acet acid metabolit bacteri transform abscis acid report discoveri new abscis acid aba metabolit found cours mass spectrometr studi aba metabol rhizospher bacterium rhodococcus sp py analogu aba enrich tritium cyclohexen moieti fed bacteri cell extract contain radioact metabolit purifi analyz determin structur obtain mass spectral fragment pattern nuclear magnet reson spectra new metabolit aba identifi hydroxi trimethyl oxo cyclohexen acet acid name rhodococc acid ra character use sever techniqu metabolit second bacteri aba degrad product addit dehydrovomifoliol describ earlier taken togeth data reveal unknown aba catabol pathway begin side chain disassembl oppos convers cyclohexen moieti plant role aba util bacteria interact microorgan plant also discuss
|
D000040;D019342
|
T123;T121;T130;T109
|
36,291,717
|
dna replic mechan explain structur variat pigeon recess red locus speci adapt environ evolut must act upon genet variat present popul elucid molecular mechan give rise variat thus crucial import understand organ evolv addit variat caus point mutat structur variat delet duplic invers transloc also import sourc varieti mechan involv recombin transposit retrotransposit replic propos generat structur variat capabl explain certain rearrang studi conduct detail analysi two partial overlap rearrang e e allel domest rock pigeon columba livia associ recess red phenotyp find replic mechan best abl explain complex architectur e allel also compat simpler architectur e allel well
|
D010856;D004261
|
T045;T012
|
36,291,716
|
stereoselect membran transport phenylethylamin deriv human monoamin transport organ cation transport stereoselect well known pronounc drug metabol receptor bind howev much less known stereoselect drug membran transport character stereoselect cell uptak chiral phenylethylamin deriv human monoamin transport net dat sert organ cation transport oct oct oct stereoselect differ extens close relat transport high affin monoamin transport mat show fold stereoselect uptak norepinephrin epinephrin well numer analog net dat preferenti transport norepinephrin sert prefer r enantiom contrast net dat show higher transport r epinephrin sert epinephrin general mat stereoselect lower expect high affin sever catecholamin high stereoselect inhibitor use antidepress addit oct differ strong stereoselect oct show almost stereoselect uptak oct character rough fold prefer r enantiom phenylethylamin contrast oct transport norphenylephrin phenylephrin fold fold prefer r enantiom respect para hydroxyl octopamin synephrin show stereoselect oct transport altogeth data demonstr stereoselect high transport substrat specif high divers even homolog transport
|
D027702;D009655
|
T123;T121;T116;T109
|
36,291,715
|
addit natur extract antioxid function preserv qualiti meat product antioxid use prevent oxid reaction inhibit develop unwant sensori characterist decreas nutrit qualiti accept shelf life process meat product improv stabil synthet antioxid although effici relat develop diseas present toxic carcinogen effect thus research meat industri studi natur altern synthet antioxid use meat product thus meet demand consum seek food without addit composit natur extract compound exert antioxid activ differ meat product differ mechan thus review work aim gather studi appli natur extract deriv differ plant sourc possibl antioxid meat product action preserv qualiti product
|
D000975;D008461
|
T123;T121;T168;T039;T044
|
36,291,714
|
divers composit role mirna non neuron cell neuron synaps alzheim diseas neuron interact astrocyt microglia vascular cell interact becom unbalanc diseas state result damag neuron synaps contribut cognit impair import synapt loss synapt dysfunct consid year main patholog factor cognit impair alzheim diseas ad recent mirna emerg essenti regul physiolog patholog process brain focus role mirna regul synapt function well differ cell type brain offer opportun earli prevent diagnosi potenti treatment ad relat cognit impair review recent research conduct mirna regul astrocyt microglia cerebrovasculatur synapt function context ad relat cognit impair also review potenti mirna relat biomark therapeut well emerg imag technolog relev ad research
|
D000544;D035683
|
T123;T047;T114;T048
|
36,291,713
|
high resolut ribosom profil reveal gene specif detail uga code selenoprotein biosynthesi co translat incorpor selenocystein sec selenoprotein occur uga codon process translat elong compet translat termin selenocystein insert sequenc bind protein secisbp great enhanc sec incorpor selenoprotein interact mrna ribosom elong factor sec efsec ribosom profil allow studi process uga code physiolog context cell time individu selenoprotein express cell use hap cell express mutant secisbp show high resolut ribosom profil use assess read effici uga selenoprotein includ sec close c terminus analysi ribosom uga either site p site reveal transcript specif manner secisbp help recruit trnasec stabil mrna propos assess effect perturb uga read determin proport ribosom carri uga p site puga addit new observ frameshift occur ugasec codon selenof selenow secisbp mutant hap cell find corrobor reanalysi neuron specif secisbprq mutant brain
|
D017279;D004251
|
T123;T116;T114;T086
|
36,291,712
|
pancreat cancer research beyond dna mutat pancreat ductal adenocarcinoma pdac caus genet mutat four gene kras proto oncogen gtpase kras tumor protein p tp cyclin depend kinas inhibitor cdkna mother decapentapleg homolog smad also call big chang tumor complex make character earli stage challeng therefor develop innov therapeut approach desir key overcom pdac diagnos earli stage therefor recent studi investig multifac characterist pdac includ cancer cell metabol mesenchym cell includ cancer associ fibroblast immun cell metagenom extend character various biomolecul includ rnas volatil organ compound various alter kras depend well kras independ pathway involv refractori pdac optim combin new technolog expect help treat intract pancreat cancer
|
D055549;D010190;D021441
|
T191;T109
|
36,291,711
|
blood adipokinescytokin young peopl chronic bronchiti abdomin obes pathogenesi develop chronic lung diseas assum particip system inflamm factor well hormon like substanc produc adipos tissu aim studi evalu associ certain adipokinescytokin chronic bronchiti background abdomin obes young peopl studi includ peopl age total peopl select random number method divid two subgroup chronic bronchiti abdomin obes chronic bronchiti without abdomin obes control group patient compar gender age also select group patient chronic bronchiti adiponectin tnfa gip level time higher level c peptid mcp pp group chronic bronchiti time higher compar control adipsin lipocalin il resistin signific higher group chronic bronchiti glucagon amylin ghrelin time lower respect group patient chronic bronchiti background abdomin obes probabl chronic bronchiti increas increas level lipocalin gip tnfa
|
D054392;D029481
|
T123;T047;T116
|
36,291,710
|
mechan periton mesotheli cell periton adhes periton adhes pa fibrot tissu connect abdomin viscer organ peritoneum format pas induc varieti clinic diseas howev current effect strategi prevent treatment pas damag periton mesotheli cell pmcs believ caus pas promot inflamm fibrin deposit fibrosi format earli stage pa format pmcs undergo mesotheli mesenchym transit abil produc extracellular matrix pmcs may transdifferenti myofibroblast acceler format pas therefor aim review understand mechan action pmcs pas offer theoret foundat treatment prevent pas
|
D010537;D005109
|
T023;T024
|
36,291,709
|
high intens exercis train improv basal platelet prostacyclin sensit potenti respons dual anti platelet therapi postmenopaus women risk thrombot event dramat increas age may acceler women cessat endogen estrogen product menopaus patient risk thrombosi prescrib dual anti platelet therapi dapt aspirin py antagonist encourag particip regular physic activ modal improv nitric oxid prostacyclin mediat inhibit platelet aggreg
|
D011464;D013927
|
T123;T046;T121;T109
|
36,291,708
|
differenti effect beta hydroxybutyr enantiom induc pluripot stem deriv cardiac myocyt electrophysiolog beta hydroxybutyr ohb along acetoacet aceton liver produc keton bodi increas fast prolong exercis altern fuel sourc glucos ohb main circul keton bodi g protein coupl receptor ligand also histon deacetylas inhibitor prompt reexamin role health diseas studi compar effect two commerci ohb formul enantiom r ohb racem mixtur ohb induc pluripot stem cell cardiac myocyt ip cms electrophysiolog cardiac myocyt cultur r ohb ohb least ten day lactat select flouvolt fluo use assay ip cms electrophysiolog found formul increas optic potenti amplitud r ohb prolong action potenti durat ohb shorten action potenti durat moreov ohb increas peak calcium transient r ohb reduc peak calcium transient co cultur glucos fatti acid amelior effect suggest ohb fuel sourc effect ohb ip cms electrophysiolog like stereoselect care must taken evalu role exogen ohb health diseas
|
D032383;D000090
|
T025;T109
|
36,291,707
|
construct analysi enzym constrain metabol model corynebacterium glutamicum genom scale metabol model gem power tool interpret predict cellular phenotyp various environment genet perturb howev gem consid stoichiometr constraint simul growth product yield valu show monoton linear increas increas substrat uptak rate deviat experiment measur valu recent integr enzymat constraint stoichiometri base gem proven effect make novel discoveri predict new engin target present first genom scale enzym constrain model eccgl corynebacterium glutamicum reconstruct integr enzym kinet data various sourc use ecmpi workflow base high qualiti gem c glutamicum obtain modifi icw model enzym constrain model improv predict phenotyp simul overflow metabol also recapitul trade biomass yield enzym usag effici final use eccgl identifi sever gene modif target l lysin product agre previous report gene studi show incorpor enzym kinet inform gem enhanc cellular phenotyp predict c glutamicum help identifi key enzym thus provid reliabl guidanc metabol engin
|
D048230
|
T007
|
36,291,706
|
drug diseas associ predict use heterogen network comput drug reposit drug reposit involv identif new therapeut indic approv drug consider reduc time cost develop new drug recent comput drug reposit method use heterogen network identifi drug diseas associ review reveal exist network base approach predict drug diseas associ three major categori graph mine matrix factor complet deep learn select eleven method three categori compar predict perform experi conduct use two uniform dataset drug diseas side separ construct heterogen network use drug drug similar base chemic structur atc code ontolog base diseas diseas similar drug diseas associ improv evalu metric use reflect data imbal posit associ typic spars predict result demonstr method graph mine matrix factor complet categori perform well overal assess furthermor predict drug side higher accuraci diseas side select integr inform drug featur drug drug similar measur crucial improv diseas side predict
|
D058492;D019295
|
T062;T091;T061
|
36,291,705
|
prognost valu high sensit cardiac troponin women high sensit cardiac troponin assay becom gold standard diagnos acut chronic myocardi injuri detect troponin level beyond th percentil includ fourth univers definit myocardi infarct specif recommend use sex specif threshold measur concentr propos diagnost threshold shown inform prognosi differ categori inpati outpati howev clinic investig last twenti year yield conflict result regard increment valu use differ cut off men women advoc sex specif approach claim may help reduc gender bias cardiovascular medicin particular acut coronari syndrom group question alleg increment diagnost prognost valu sex specif threshold ultim assert less present review aim synthes current understand sex base differ cardiac troponin level reapprais avail evid regard prognost signific sex specif diagnost threshold high sensit cardiac troponin assay compar common cut off men women undergo cardiovascular diseas risk assess ii clinic util high sensit cardiac troponin assay cardiovascular diseas prevent women
|
D063507;D054058
|
T047;T054
|
36,291,704
|
editori special issu hyaluron acid human medicin hyaluron acid ha acid non sulfat glycosaminoglycan intens studi biodegrad biocompat materi scaffold regen medicin clinic applic
|
D006820;D001672
|
T123;T122;T121;T109
|
36,291,703
|
crystal structur human copper chaperon atox bound zinc ion bioavail copper cu human cell may depend complex interplay zinc zn ion investig abil zn ion target human cu chaperon atox small cytosol protein capabl anchor cu conserv surfac expos cys x x cys cxxc motif deliv cu transport atpas tran golgi network crystal structur atox load zn display metal ion bridg cxxc motif two atox molecul homodim ident locat zn ion confirm anomal scatter metal collect x ray diffract data near zn k edg furthermor soak experi zn load atox crystal strong chelat agent edta caus limit remov metal ion tetrahedr coordin cage suggest potenti role atox zn metabol general cu zn transport mechan could interlock human cell
|
D056511;D003300
|
T123;T196;T121;T116
|
36,291,702
|
gene deliveri manf beta cell pancreat islet protect nod mice type diabet develop type diabet dysfunct glucos regul occur due death insulin produc beta cell pancreat islet initi process caus inherit adapt immun system predispos respond beta cell antigen notabl insulin coupl unknown environment insult prime autoimmun reaction autoimmun primari driver beta cell death grow evid cellular stress particip loss beta cell beta cell fragil model partial loss islet mass requir compensatori upregul insulin product remain islet drive cellular stress capabl trigger apoptosi remain cell glis manf axi identifi pivot relat fragil robust stress islet potenti oper type type diabet use aav base gene deliveri system enhanc express anti apoptot protein manf beta cell nod mice gene deliveri substanti lower rate diabet develop treat mice manf treat mice demonstr minim insul superior preserv insulin product result demonstr therapeut potenti manf deliveri enhanc beta cell robust avert clinic diabet
|
D003922;D003924;D007515
|
T047;T023
|
36,291,701
|
compar analysi mesophil yqfb type amidohydrolas widespread superfamili human activ signal cointegr homolog asch domain identifi almost year ago howev amount experiment data regard biolog function domain scarc studi aim determin putat cellular function four hypothet asch domain contain amidohydrolas yqfb analogu investig activ toward various n acyl cytosin deriv includ potenti nucleosid deriv prodrug well abil binddegrad nucleic acid vitro accord determin kinet paramet n acetylcytidin assum primari substrat amidohydrolas despit similar protein contain pua domain nucleic acid bind activ detect yqfb like protein suggest vivo enzym part pyrimidin salvag pathway also demonstr possibl express yqfb type amidohydrolas prokaryot eukaryot host small protein size remark halotoler yqfb type amidohydrolas great interest fundament research biotechnolog applic
|
D000581;D011355
|
T120;T126;T116
|
36,291,700
|
qualiti evalu ophiopogon japonicus two authent geograph origin china base physicochem pharmacolog properti polysaccharid ophiopogon japonicus wide use tonic herb china accord origin maidong chines materia medica classifi zhe maidong ophiopogon japonicus zhejiang chuan maidong ophiopogon japonicus sichuan duant maidong liriop muscari hubei maidong liriop spicata term qualiti control polysaccharid base evalu yet conduct studi microwav assist extract mae use prepar polysaccharid batch maidong hpsec mall rid hpaec pad employ investig molecular paramet composit monosaccharid respect abil scaveng abt radic immun promot abil term nitric oxid releas phagocytosi raw macrophag also compar result show polysaccharid differ maidong vari molecular paramet polysaccharid main contain fructos glucos small amount arabinos mannos galactos xylos polysaccharid zhe maidong chuan maidong molar ratio fru glc rough respect zhe maidong exhibit better antioxid immun promot activ fibrous root pharmacolog activ howev account variat growth year final indic qualiti control base multivari statist analysi includ yield antioxid activ content fructos ri signal conclud maidong fibrous root similar compon root qualiti signific affect growth age may provid guidanc cultiv use maidong
|
D031441;D008419
|
T121;T002
|
36,291,699
|
combin antimalari cns drug antineoplast agent mcf breast ht colon cancer cell biosafeti evalu mechan action drug combin drug repurpos two strategi allow find novel oncolog therapi faster econom process previous studi develop novel model drug combin use antineoplast differ repurpos drug demonstr combin doxorubicin dox artesun dox chloroquin paclitaxel ptx fluoxetin ptx fluphenazin ptx benztropin induc signific cytotox michigan cancer foundat mcf breast cancer cell furthermor found fu thioridazin fluorouracil fu sertralin synergist induc reduct viabil human colorect adenocarcinoma cell line ht studi aim evalu biosafeti profil drug combin non tumor cell determin mechan action cancer cell human fetal lung fibroblast cell mrc fibroblast cell incub h drug alon combin concentr time half maxim inhibitori concentr ic cell morpholog viabil evalu next design construct cell microarray perform immunohistochemistri studi evalu palmitoyl protein thioesteras ppt ki cleav poli adp ribos polymeras cleav parp multidrug resist associ protein mrp p glycoprotein p gp nuclear factor kappa b nf kb p express demonstr combin cytotox cancer cell safe non tumor cell lower concentr furthermor also demonstr ppt may import role mechan action combin demonstr abil decreas ppt express result support use antimalari central nervous system cns drug combin regimen chemotherapeut agent nevertheless addit studi recommend explor complet mechan action
|
D000962;D000970;D001943;D003110
|
T121;T191;T109
|
36,291,698
|
current challeng biolog treatment pharmaceut base contamin oxidoreductas enzym immobil process real aqueous matric hybrid techniqu worldwid access pharmaceut continu releas environ rais serious global concern pharmaceut remain activ even low concentr therefor occurr waterbodi may lead success deterior water qualiti advers impact ecosystem human health address challeng current evolv trend toward search effect method ensur effici purif drink water wastewat biocatalyt transform pharmaceut use oxidoreductas enzym peroxidas laccas promis environment friend solut water treatment fungal speci use prefer produc due ligninolyt enzymat system enzym catalyz degrad transform micropollut bioavail even innocu product enzym immobil carrier general increas stabil catalyt perform allow reus promis approach ensur applic industri scale process moreov coupl biocatalyt process treatment technolog reveal effect approach achiev complet remov pharmaceut review updat state art applic oxidoreductas enzym name laccas degrad pharmaceut spike water real wastewat moreov advanc concern techniqu use enzym immobil oper bioreactor use redox mediat applic hybrid techniqu well discuss transform mechan end toxic address
|
D060766;D014874
|
T131;T167
|
36,291,697
|
lipidom reveal plasma phospholipid profil differ deceas recov covid patient thorough understand metabol chang includ lipidom alter associ develop covid appear crucial new type coronavirus still report studi analyz differ plasma phospholipid profil deceas covid patient recov healthi peopl due identifi abnorm plasma phospholipid profil deceas patient divid two subgroup increas level phosphatidylethanolamin pe phosphatidylcholin pc phosphatidylserin ps found plasma recov patient major deceas patient first subgroup compar control group howev abund relev pe pc ps speci decreas dramat plasma second subgroup five deceas patient patient also signific decreas plasma cox activ compar control contrast unchang increas cox activ plasma deceas patient recov patient respect moreov five deceas patient character abnorm low crp level tremend increas ldh level may result pathophysiolog disord includ disord immun system liver damag haemolyt anemia addit observ trend decreas autoantibodi oxid modif low densiti lipoprotein olab titer especi deceas patient indic system oxid stress alter immun system may prognost valu covid
|
D010743;D000086382
|
T123;T047;T067;T109
|
36,291,696
|
identif biolog function prognost valu nnmt oral squamous cell carcinoma nicotinamid n methyltransferas nnmt metabol enzym catalyz methyl nicotinamid nam generat methyl nicotinamid mnam although previous studi shown nnmt frequent dysregul promot onset progress mani malign express profil prognost valu function oral squamous cell carcinoma oscc still unknown
|
D009062;D002294;D006258
|
T191
|
36,291,695
|
function tune intrins disord region human protein composit bias intrins disord region idr protein sequenc flexibl low structur constraint result faster rate evolut lack evolutionari conserv great limit use sequenc homolog classif function assess idr oppos globular domain studi idr requir properti classif function predict composit bias necessari properti idr composit bias region cbrs note frequent part idr hypothes character idr could help studi overlap particular type cbrs evalu overlap human proteom total residu idr overlap cbrs consid cbrs enrich one type amino acid distinguish cbrs tend fulli includ within long idr r h n p g partial overlap shorter idr e k other tend overlap idr termin q cbrs overlap often idr nuclear protein protein involv liquid liquid phase separ llps studi protein interact network reveal enrich cbrs idr tandem repetit short linear motif rich p exist e rich polar region could support specif protein interact non specif interact result open way pin function idr partial composit bias
|
D064267
|
T123;T116
|
36,291,694
|
methylsulfonyl hexyl isothiocyan chemoprevent agent induc autophagi leukemia cell line autophagi fundament catabol process cellular surviv role autophagi cancer high complex earli stage neoplast transform act tumor suppressor avoid accumul protein damag organell reactiv oxygen speci ros advanc stage cancer autophagi exploit cancer cell surviv starvat methylsulfonyl hexyl isothiocyan mitc interest compound wasabia japonica rizhom recent prove abil induc cytotox cytostat cell differenti effect leukem cell line antimutagen activ tk cell current studi defin chemoprevent profil jurkat hl cell treat mitc h modul autophag process involv ros level possibl trigger mechan analyz flow cytometri found mitc induc autophagi jurkat hl cell highest concentr test increas ros intracellular level dose depend manner result implement avail data support mitc attract potenti chemoprevent agent
|
D054697;D007938
|
T121;T191
|
36,291,693
|
effect atomoxetin motor cognit behavior brain electrophysiolog activ dopamin transport knockout rat chang dopaminerg noradrenerg transmiss consid under caus attent deficit hyperact disord adhd atomoxetin atx select norepinephrin transport net inhibitor current use adhd treatment studi aim evalu effect atomoxetin behavior brain activ dopamin transport knockout dat ko rat character adhd like behavior phenotyp prepuls inhibit ppi assess dat ko wild type rat salin atx inject well behavior paramet hebb william maze power spectra coher electrophysiolog activ dat ko rat demonstr pronounc behavior electrophysiolog phenotyp character hyperact increas number error maze repetit behavior disrupt ppi chang cortic striatal power spectra interar coher atomoxetin signific improv ppi decreas repetit behavior dat ko rat influenc behavior wild type rat atx also led signific chang power spectra coher dat ko wild type rat assess noradrenerg modul effect dat ko provid insight intric interplay monoaminerg system although research still requir fulli understand complex interact
|
D050483;D050484
|
T123;T116;T192
|
36,291,692
|
identif molecular subtyp novel prognost model sepsi base ferroptosi associ gene signatur ferroptosi recent associ immunolog chang sepsi howev clinic signific ferroptosi associ gene fag remain unknown paper fag base prognost model construct sepsi patient use integr machin learn approach prognosi model compos fag classifi patient high low risk base immunolog studi found immun status differ high risk low risk cluster cox regress analysi reveal fag independ risk factor overal surviv sepsi patient roc curv nomogram reveal fag base model robust prognosi predict last neddl identifi fag potenti hub gene sepsi predict
|
D000079403;D018805
|
T047;T046;T043
|
36,291,691
|
effect one year tofacitinib therapi lipid adipokin associ vascular pathophysiolog rheumatoid arthriti cardiovascular cv morbid mortal metabol syndrom associ rheumatoid arthriti ra recent trial suggest increas risk major cv event mace upon janus kinas jak inhibitor tofacitinib compar anti tumor necrosi factor tnf therapi studi evalu lipid metabol marker relat vascular function clinic marker ra patient undergo one year tofacitinib therapi
|
D001172;D000075242
|
T121;T047
|
36,291,690
|
prognost impact relat lipid profil patient myocardi infarct prospect cohort studi background vivo studi show inhibit progress atherosclerosi predict lower risk recurr ischemia patient acut myocardi infarct ami could mediat modul lipid metabol current studi aim investig effect various lipid content prognost impact patient ami method total consecut ami patient prospect recruit march januari patient first stratifi two group median level stratifi level various lipid content proprotein convertas subtilisinkexin type pcsk cox regress multipl adjust perform analyz associ lipid profil pcsk various outcom primari outcom major advers cardiovascular event mace composit caus death recurr mi ischem stroke result median follow day total mace occur high level associ lower risk mace patient elev lipoprotein mgl hazard ratio hr confid interv ci p pcsk level median ngml hr ci p amp lt observ without elev lp amp lt mgl hr ci p pinteract pcsk amp lt ngml hr ci p pinteract conclus patient ami high level associ lower ischem risk among patient elev lp pcsk
|
D000071449;D009203
|
T047;T126;T116
|
36,291,689
|
exom sputum microbiota predict marker frequent exacerb chronic obstruct pulmonari diseas frequent acut exacerb lead caus high rate hospit mortal chronic obstruct pulmonari diseas copd despit enorm worldwid medic burden reliabl molecular marker effect earli diagnosi prognosi acut exacerb still lack host genet airway microbiom known play potenti role pathogenesi frequent exacerb perform whole exom sequenc wes rrna gene sequenc explor interact two factor implic pathogenesi frequent exacerb collect peripher blood n sputum sampl n clinic data frequent exacerb phenotyp fe copd patient infrequ exacerb phenotyp ie control base filter deleteri site candid mutat gene share fe patient occur ie group identifi microbiota analysi reveal signific differ bacteri divers composit fe ie group report under pathogen gene includ aatf htt cep adamt tll gene etc explor possibl genotyp phenotyp correl microbiota dysbiosi import observ aatf gene mutat signific negat correl microbi rich divers studi indic sever deleteri mutat candid gene might associ microbi dysbiosi increas risk frequent acut exacerb copd patient result provid novel evid exom relat microbiom may potenti serv biomark predict frequent acut exacerb copd patient
|
D029424;D064307
|
T001;T047;T032;T028
|
36,291,688
|
quantifi coexist concentr multi compon phase separ system use analyt hplc last decad evid accumul suggest numer instanc cellular compartment explain phenomenon phase separ process macromolecular solut separ spontan dens dilut coexist phase semi quantit vitro approach measur phase boundari proven use determin key featur biomolecular condens method often lack precis necessari generat quantit model therefor clear need techniqu allow quantit coexist dilut dens phase concentr phase separ biomolecul especi system one type macromolecul report design deploy analyt high perform liquid chromatographi hplc vitro separ quantif distinct biomolecul allow us measur dilut dens phase concentr need reconstruct coexist curv multicompon mixtur approach label free detect lower amount materi access classic uv spectrophotomet applic broad rang macromolecul interest semi high throughput techniqu need macromolecul recov use approach promis provid quantit insight balanc homotyp heterotyp interact multicompon phase separ system
|
D002851
|
T059
|
36,291,687
|
intercellular communic reveal therapeut potenti epitheli mesenchym transit tripl negat breast cancer background tripl negat breast cancer tnbc aggress subtyp breast cancer high intra tumor heterogen epitheli mesenchym transit emt one induc cancer metastasi migrat howev descript emt process tnbc use singl cell rna sequenc scrna seq remain unclear method studi analyz cellular gene express profil five tnbc patient first score malign cell base function pathway determin emt characterist pseudo time trajectori analysi employ character cell trajectori furthermor cellchat use identifi cellular communic result identifi epithelium like mesenchym like malign cell respect pseudo time trajectori analysi indic transit trend epithelium like mesenchym like malign cell character potenti regul emt process identifi dysregul transcript factor tfs epithelium like mesenchym like malign cell overexpress forkhead box protein foxa recogn poor prognosi marker tnbc furthermor dissect cell cell communic via ligand receptor l r interact observ tumor associ macrophag tam may support invas malign epitheli cell base cxcl cxcr signal tumor necrosi factor tnf signal pathway secret tam identifi outgo communic pattern mediat communic monocytestam malign epitheli cell altern tnf relat ligand receptor l r pair show promis clinic implic immunotherapi anti neoplast drug could interact l r pair potenti strategi treatment tnbc summari studi enhanc understand emt process tnbc microenviron dissect emt relat cell communic also provid us potenti treatment target
|
D058750;D064726
|
T191;T043
|
36,291,686
|
mmp uch l proteasom potenti biomark support diagnosi brain glioma diagnosi brain glioma main base imag method gold standard area mri recommend prevent diagnosi treatment glioma period modifi updat one diagnost techniqu use brain glioma suspect liquid biopsi howev techniqu requir develop confirm effect paper present propos three potenti biomark brain glioma extracellular matrix metalloproteinas mmp ubiquitin carboxi termin hydrolas l uch l proteasom quantifi blood plasma use spri biosensor statist analysi result indic signific chang concentr control group k grade g g similar grade g g howev differ concentr group kgg gg statist signific posit averag correl found concentr protein patient age individu test protein also high correl work propos new diagnost techniqu may aid diagnosi brain glioma
|
D043222;D005910
|
T191;T126;T116
|
36,291,685
|
compar genom analysi uncov chloroplast genom variat phylogenet relationship camellia speci camellia largest genus famili theacea due phenotyp divers frequent hybrid polyploid understand phylogenet relationship camellia speci remain challeng compar chloroplast cp genom provid inform resourc phylogenet analys camellia studi chloroplast genom sequenc nine camellia speci determin use illumina sequenc technolog via de novo assembl cp genom size rang bp organ quadripartit region typic angiosperm cp genom genom harbor protein code transfer rna ribosom rna gene order orient differ long short sequenc repeat snps indel detect across cp genom combin complet cp sequenc seven speci genus camellia total nine intergen sequenc diverg hotspot protein code gene high sequenc polymorph identifi hotspot especi indel bp locat atph atpi region suffici potenti use barcod marker phylogenet analysi speci identif princip compon phylogenet analysi suggest region constraint rather function constraint strong affect sequenc evolut cp genom studi cp genom could facilit develop new molecular marker accur speci identif investig phylogenom relationship genus camellia
|
D054628;D028244
|
T002;T028
|
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