PMID
int64
35.7M
36.4M
Title/Abstract
stringlengths
22
8.78k
MeshTerms
stringlengths
7
101
SemanticTypes
stringlengths
4
64
36,292,596
cerebellar abiotrophi australian work kelpi associ two major risk loci autosom recess form inherit cerebellar abiotrophi ca character degener purkinj granul cell cerebellar cortex occur australian work kelpi dog breed clinic sign ca includ ataxia head tremor motor coordin wide base stanc high step gait investig clinic ...
D004283;D002526;D002524;D019636
T033;T184;T047
36,292,595
microrna epitheli mesenchym transit fuch endotheli corneal dystrophi review mirna express connect epitheli mesenchym transit studi fuch endotheli corneal dystrophi fecd
D035683;D005642
T123;T047;T114
36,292,594
genom predictor brisk walk associ elit sprinter status brisk walker physic activ taller reduc bodi fat greater physic fit muscl strength aim studi determin whether genet variant associ increas walk pace overrepres elit sprinter compar control total singl nucleotid polymorph snps previous identifi genom wide associ stud...
D055106;D018737
T063;T081;T040
36,292,593
singl cell sequenc reveal mechan persist truncus arteriosus format pdgfr pdgfr doubl knockout cardiac neural crest cell persist truncus arteriosus pta uncommon complex congenit cardiac malform account congenit heart diseas chds caus defici embryon heart outflow tract oft septat remodel pdgfr pdgfr doubl knockout dko ca...
D009432;D014339
T018;T025;T019
36,292,592
rare diseas educ outsid classroom clinic evalu rare compass program undergradu medic student launch rare compass program first intern educ program pair medic student rare diseas patient order enhanc exposur comfort rare diseas part ongo qualiti improv studi retrospect review four year particip registr data conduct prog...
D013337;D004504
T065;T097
36,292,591
compar transcriptom srnaom analys reveal regulatori mechan fruit ripen spontan earli ripen navel orang mutant wild type complex molecular regulatori network play import role develop ripen fruit lead signific differ appar characterist compar transcriptom srnaom analys perform reveal regulatori mechan fruit ripen spontan...
D032084;D035683
T168;T123;T002;T114
36,292,590
chloroplast genom analysi genet inform authent five barleria speci order authent genom inform barleriacristata l b lupulina lindl b repen nee b siamensi craib b strigosa willd cp genom investig reveal general structur total size bp genom encod total gene includ cds trna rrna gene detail found follow differ number type ...
D054628;D027901
T002;T028
36,292,589
free fatti acid overload target mitochondria gene express analysi palmit acid treat endotheli cell lipotox known caus cellular dysfunct death non adipos tissu major caus lipotox accumul satur free fatti acid ffa palmit acid pa common satur fatti acid found human bodi endotheli cell form blood vessel first non adipos ce...
D019308;D005230
T123;T122;T109
36,292,588
intrins disord bap associ uveal melanoma specif subvari uveal melanoma um associ increas rate metastasi compar subvari brca breast cancer gene associ protein bap encod gene link aggress behavior um
D064267;D014604
T123;T191;T116
36,292,587
incident find studi particip research oblig technolog advanc genom test becom commonplac incident find discoveri unrel result increas american colleg genet genom acmg establish recommend return patholog variant gene clinic set base medic action condit gene link prevent treatabl diseas howev lack polici research set pos...
D033162;D023281
T033;T091
36,292,586
popul structur finless porpois neophocaena phocaenoid discov coastal water republ korea finless porpois neophocaena phocaenoid cuvier distribut coastal water asia throughout indonesia east far north taiwan strait finless porpois declar critic endang wwf world wide fund natur rate vulner iucn red threaten speci list sin...
D019576
T015
36,292,585
differenti methyl dna region left ventricular hypertrophi african american hypergen studi left ventricular lv hypertrophi lvh independ risk factor cardiovascular diseas african american experi dispar high risk lvh genet studi identifi potenti candid gene variant relat condit epigenet modif may continu help unravel dise...
D017379;D006973
T047
36,292,584
melatonin function crosstalk phytohormon normal stress condit melatonin discov plant late nineti role signal crosstalk phytohormon remain unknown research melatonin plant risen dramat recent year role putat plant hormon biotic abiot stress condit report present review discuss main function melatonin growth develop plan...
D010937;D008550
T125;T121;T116;T109
36,292,583
estim metabol effect upon cadmium exposur pregnanc use tensor decomposit simpl tensor decomposit model appli liver transcriptom analysi data elucid caus cadmium induc gene overexpress addit estim mechan prenat cd exposur disrupt insulin metabol offspr numer studi report toxic cd liver transcriptom analysi reveal cd tox...
D002104;D014409
T129;T131;T196;T116
36,292,582
grant motif regul cenp incorpor restrict rna polymeras ii access centromer precis chromosom segreg essenti maintain genom stabil proper execut center centromer chromosom locus mount kinetochor complex mediat attach chromosom spindl microtubul locat centromer epigenet determin centromer specif histon h variant cenp mani...
D006657;D012568
T123;T004;T116
36,292,581
chase consist updat tcp gene famili malus domestica member teosint branch cycloideaprolifer cell factor tcp transcript factor gene famili malus domestica domestica identifi first genom assembl releas higher qualiti genom assembl appl releas consid refer genom moreov sever speci identifi tcp gene name base relat posit g...
D027845;D017360
T168;T002
36,292,580
genom wide analysi express profil voz gene famili quinoa chenopodium quinoa vascular plant one zinc finger voz protein plant specif transcript factor famili play import role plant develop stress respons howev littl known voz gene quinoa present studi genom wide investig voz gene famili quinoa perform includ gene struct...
D027465
T168;T002
36,292,579
novel framework analysi share genet background correl trait propos novel effect framework analysi share genet background set genet correl trait use snp level gwas summari statist framework call shaher base construct linear combin trait maxim proport genet varianc explain share genet factor shaher requir full gwas summa...
D020641;D055106
T063;T086
36,292,578
identif hypomorph fancg variant bernes mountain dog bernes mountain dog bmds overal cancer incid half compris otherwis rare tumor histiocyt sarcoma hs recent studi identifi driver mutat mapk pathway identif key predispos gene elus studi identifi sever loci associ predisposit hs bmds includ near mtapcdkna region causat ...
D005199;D054747
T047;T191
36,292,577
increas risk hereditari prostat cancer italian famili hereditari breast ovarian cancer syndrom harbor mutat brca suscept gene hereditari prostat cancer hpca highest herit cancer men interest occur sever hereditari syndrom includ breast ovarian cancer hboc lynch syndrom ls sever gene mutat relat syndrom identifi biomark...
D061325;D011471
T191
36,292,576
compar phylogenet analys complet chloroplast genom scrophularia incisa complex scrophulariacea scrophularia incisa complex group close relat desert stepp subshrub includ incisa kiriloviana dentata sect canina compon found northwest china base earlier molecular evid speci boundari phylogenet relationship within complex ...
D054628;D032266;D028083
T002;T028
36,292,575
whole exom sequenc reveal pathogen sirt variant brain arterioven malform case report arterioven malform brain bavm plexus patholog arteri vein lack normal capillari system intracrani hemorrhag hemorrhag stroke frequent clinic manifest avm lead lethal outcom especi high among children young peopl recent high throughput ...
D056564;D002538
T019;T126;T116
36,292,574
review applic near infrar spectroscopi two rare disord execut neurolog dysfunct ucd pku studi rare diseas particular neurolog dysfunct challeng research healthcar profession due complex small popul geograph dispers univers standard biomark generat tool function neuroimag forg collect baselin data well treatment effect ...
D019265;D035583
T047;T059
36,292,573
develop valid mps base system human appear predict challeng forens sampl forens dna phenotyp fdp provid abil predict human extern trait unknown sampl donor direct minut amount dna found crime scene develop mps multiplex assay aim genotyp dna marker includ hirisplex system simultan predict eye hair skin colour forens sa...
D005127;D020641
T032;T086
36,292,572
missens variant gfra npnt associ congenit anomali kidney urinari tract use next generat sequenc ngs help identifi mani gene caus congenit anomali kidney urinari tract cakut bilater renal agenesi bra sever present cakut associ autosom recess inherit gene expand high consanguin popul impact detect recess inherit gene rep...
D014551
T023
36,292,571
identif two novel epor gene variant primari famili polycythemia case report literatur review primari famili congenit polycythemia rare diseas character increas red cell mass may due pathogen variant epo receptor epor gene date genet variant report associ analyz presenc epor variant two patient polycythemia jak pathogen...
D017467;D011086
T033;T047;T116;T192
36,292,570
paleogenom reveal complex evolutionari histori late pleistocen bison northeastern china stepp bison typic repres mid late pleistocen stepp northern hemispher despit abund fossil remain mani question relat genet divers popul structur dispers rout still elus present near complet partial mitochondri genom well partial nuc...
D016164;D054629
T015;T028
36,292,569
genet dysrupt histaminerg pathway novel delet q locus associ variabl express neuropsychiatr disord involv histaminerg system hs neuropsychiatr diseas well document studi describ patient affect differ neuropsychiatr condit harbour disrupt gene involv hs human histamin synthetis histidin histidin decarboxylas enzym encod...
D006640;D005879
T047;T126;T116
36,292,568
popul genet data insert delet marker polish popul background insert delet indel marker show advantag short tandem repeat strs singl nucleotid polymorph snps consid altern marker forens genet method allel frequenc correspond forens effici paramet autosom polymorph indel loci includ investig dipplex kit qiagen obtain sam...
D005828;D054643
T045;T090
36,292,567
genom wide investig character sweet gene famili focus evolut express hormon abiot stress respons maiz sugar eventu export transport sweet famili import group transport carrier carbon partit plant import function growth develop abiot stress toler although sweet famili import sugar transport littl known function sweet fa...
D003313;D018506
T045;T168;T002
36,292,566
crisprca mediat gene edit bnfad bnfae modifi fatti acid profil brassica napus fatti acid fa composit determin qualiti oil oilse crop thus major target genet improv fad fatti acid dehydrogenas fae fatti acid elongas critic fa synthet gene focus genet manipul alter fatti acid composit oilse plant studi improv nutrit qual...
D029688
T168;T002
36,292,565
character crh bind protein crhbp chicken molecular clone tissu distribut investig role negat feedback regul within hypothalamus pituitari adren axi corticotropin acth pituitari hormon play import role stress respons within hypothalamus pituitari adren hpa axi biosynthesi secret acth control multipl factor includ cortic...
D010913;D007030
T022;T030
36,292,564
nois reduct sensit enhanc sleep beauti base tet system tetracyclin induc system wide use control element mammalian gene express despit multipl iter improv induc use still compromis basal promot activ absenc tetracyclin mammalian system previous show introduct gv mutat rtta tetracyclin activ lower basal level express in...
D013752;D000076962
T129;T116;T192;T109;T195
36,291,751
cholesterol content low densiti lipoprotein associ year mortal acut heart failur patient consid relationship extent metabol derang diseas sever heart failur hypothes lipid content low densiti lipoprotein vldl may prognost valu year mortal acut heart failur ahf baselin serum level vldl cholesterol vldl c vldl triglyceri...
D008079;D006333
T123;T047;T046;T116
36,291,750
type interferon receptor subunit delet attenu experiment abdomin aortic aneurysm format type interferon receptor signal contribut sever autoimmun vascular diseas lupus atherosclerosi stroke purpos studi assess influenc type interferon receptor defici format progress experiment abdomin aortic aneurysm aaa
D017544
T047
36,291,749
new betulin deriv nitrogen heterocycl moieti synthesi anticanc activ vitro part search new medicin substanc potenti applic oncolog synthesi new compound combin betulin molecul indol system carri structur ester deriv obtain steglich reaction confirm spectroscop method h c nmr hr ms obtain new indolyl betulin deriv evalu...
D014315;D000970;D001943
T121;T191;T109
36,291,748
automat cell type annot use marker gene singl cell rna sequenc data recent advanc singl cell rna sequenc scrna seq technolog gain attent cell type annot play essenti role scrna seq data analysi sever comput method propos automat annot tradit cell type annot first cluster cell use unsupervis learn method base gene expre...
D059010;D059467
T081;T059;T086
36,291,747
heat shock protein upregul supplement complex mrna alter autoimmun glaucoma glaucomat optic neuropathi common caus blind elev intraocular pressur main risk factor also contribut immun system seem like experiment autoimmun glaucoma model use system immun optic nerv homogen antigen ona lead retin ganglion cell rgc optic ...
D005901;D009901
T047
36,291,746
gerstmann strussler scheinker diseas fs mutat induc independ tau prion protein patholog bank vole gerstmann strussler scheinker diseas gss rare genet prion diseas larg gss kindr link serin phenylalanin substitut codon prion protein gene gss fs character conspicu accumul prion protein prp amyloid deposit neurofibrillari...
D016098;D011328
T047;T005;T116
36,291,745
aortic aneurysm dissect heterogen molecular mechan aortic aneurysm dissect aad devast aortic diseas high risk aortic ruptur lead uncontrol bleed death
D017545;D000784;D001014
T047;T046
36,291,744
effect psychotrop medic somat sterol biosynthesi adult mice polypharmaci common use treat psychiatr disord combin often includ drug sterol biosynthesi inhibit side effect includ antipsychot aripiprazol ari antidepress trazodon trz effect psychotrop medic poor understood across various tissu type date investig effect ar...
D014150;D014196
T121;T039;T109
36,291,743
model hyperglycaemia epitheli membran model biophys characteris biomimet model valuabl platform improv knowledg molecular mechan govern membran driven process patho physiolog condit includ membran permeabl transport fusion howev current membran model simplist includ membran lipid remodel respons extracellular stimuli s...
D006943;D010714
T033;T123;T047;T109
36,291,742
molecular classif gene associ hypox lipid metabol pancreat cancer abnorm lipid metabol often occur hypox microenviron import energi supplement cancer cell prolifer metastasi aim explor lipid metabol characterist gene express featur pancreat ductal adenocarcinoma pdac relat hypoxia identifi biomark molecular classif bas...
D010190;D021441
T191
36,291,741
mitochondri dysfunct high intraocular pressur induc retin ischemia minipig model purpos retin ischemia ri progress neuron death sight threaten condit mitochondri mt dysfunct fusionfiss process suggest play role pathophysiolog ri studi focus chang mt paramet neuroretina retin pigment epithelium rpe choroid porcin high i...
D002292;D005901;D007680
T047;T191
36,291,740
molecular regul heme oxygenas express ef transcript factor lung fibroblast cell relev idiopath pulmonari fibrosi idiopath pulmonari fibrosi ipf fatal chronic lung diseas heme oxygenas hmoxho enzym catalyz degrad heme role ho pathogenesi ipf studi howev molecular regul ho role ipf still unclear studi found ho protein le...
D054990
T047
36,291,739
ep pred machin learn tool bioprospect promiscu ester hydrolas bioprospect novel industri enzym substrat promiscu desir properti increas reusabl enzym among industri enzym ester hydrolas great relev demand ceas increas howev search new substrat promiscu ester hydrolas trivial sinc mechan behind properti great influenc a...
D065132;D004950
T062;T126;T116
36,291,738
advanc molecular biomark cardiolog cardiovascular diseas cvd repres lead caus death world despit innov therapi advanc general manag patient
D002309;D002318
T047;T091
36,291,737
acyl n methylserotonin branch chain acylserotonin lemon citrus seed new lipid antioxid properti potenti pharmacolog applic found previous unknown compound seed lemon citrus speci tangerin grapefruit pomelo structur compound character hr ms spectrometri fluoresc spectroscopi chemic synthesi compound predomin long chain ...
D002957
T168;T002
36,291,736
epigenet dimens protein structur intrins weak alphafold program one import lesson learn sequenc human genom protein structur fact larg part human proteom made intrins disord protein idp adopt multipl structur therefor multipl function depend ligand interact condit one wonder valu algorithm develop predict structur prot...
D064267
T123;T116
36,291,735
tnp analogu inhibit virul promot ip kinas arg fungal pathogen cryptococcus neoforman new antifung uniqu mode action urgent need treat increas global burden invas fungal infect fungal inositol polyphosph kinas ipk pathway compris ipk convert ip ip provid promis new target due impact multipl critic cellular function unli...
D003455;D003453
T047;T004
36,291,734
cyclosporin deliveri platform veterinari ophthalmolog new concept advanc ophthalmolog cyclosporin csa select revers immunosuppress agent wide use medic wide spectrum diseas human graft versus host diseas non infecti uveiti rheumatoid arthriti psoriasi atop dermat furthermor csa use treat keratoconjunct sicca chronic su...
D009885;D014605;D007634
T047;T091
36,291,733
smn physiolog downregul wild type motor nerv termin aggreg togeth neurofila sma mous model surviv motor neuron smn essenti ubiquit express protein particip sever aspect rna metabol smn defici caus devast motor neuron diseas call spinal muscular atrophi sma smn form core protein complex local cytoplasm nuclear gem catal...
D007382;D009134
T026;T047
36,291,732
synthesi protein oligonucleotid conjug nucleic acid protein form two key class function biomolecul abil access specif protein oligonucleotid conjug broader rang function molecul becom access leverag programm recognit potenti nucleic acid structur chemic function divers protein herein summar avail conjug strategi access...
D009841;D009696
T123;T114
36,291,731
grape pulp fiber possibl fine agent red wine one biggest problem use tradit fine agent present allergen characterist suitabl vegan consum due anim origin altern tradit proteinac agent could cell wall grape pulp materi could use modifi final phenol concentr wine due affin phenol compound studi abil freez dri grape pulp ...
D027843
T129;T168;T116;T002
36,291,730
zebrafish model sever combin immunodefici scid due jak mutat jak princip activ member interleukin receptor famili play essenti role lymphoid develop inactiv jak mutat caus autosom recess sever combin immunodefici scid studi aim generat equival zebrafish model scid character model across life cours genom edit zebrafish ...
D016511
T047
36,291,729
method radiolabel nanoparticl spect use part use nanoparticl nps rapid increas nuclear medicin nm diagnost therapeut purpos wide use due chemic physic characterist possibl deliv sever molecul nps synthetis organ andor inorgan materi differ size shape chemic composit charg factor influenc biodistribut clearanc target ab...
D053758
T073
36,291,728
copper depend kinas role cancer incept progress metastasi recent year copper function expand beyond consolid role cofactor enzym catalysi recent paper demonstr new dynam role copper regul cell signal pathway direct interact protein kinas modul activ activ pathway exacerb cancer cell sustain differ step tumor growth dis...
D003300;D009369
T123;T196;T121;T191
36,291,727
promis candid tendon heal event pdgf bb tendon injuri one common musculoskelet disord patient seek medic aid reduc qualiti life patient also impos signific econom burden societi administr growth factor wound site feasibl solut enhanc tendon heal platelet deriv growth factor bb pdgf bb well defin safeti profil compar gr...
D011788;D013710
T078;T023
36,291,726
method radiolabel nanoparticl pet use part use radiolabel nanoparticl nps promis nuclear medicin tool diagnost therapeut purpos thank heterogen materi organ inorgan uniqu physic chemic characterist high versatil use sever medic applic particular shown interest result radiolabel probe positron emiss tomographi pet imag ...
D049268;D053758
T060;T073
36,291,725
ligand promot surfac solubil tio nanoparticl enterobactin siderophor biolog medium titanium dioxid nanoparticl tio nps increas use consum product particular properti even though tio consid chemic stabl insolubl studi behavior biolog environ great import figur potenti dissolut transform interact tio nps differ size crys...
D014025;D053758
T196;T073
36,291,724
streptococcus mutan affect surfac topographi electrochem behavior nanostructur bulk ti metabol carbohydr streptococcus mutan lead format lactic acid oral caviti consequ acceler degrad dental implant fabric commerci avail microcrystallin ti microstructur influenc surfac topographi henc interact bacteria cell ti surfac w...
D013295;D015921
T007;T074
36,291,723
amygdalin review characterist antioxid potenti gastrointestin microbiota intervent anticanc therapeut mechan toxic encapsul bioactiv amygdalin found high concentr bitter almond recogn symbol cyanogen glycosid chemic organ substanc initi develop pharmaceut treat cancer hydrolyz hydrogen cyanid hcn regrett research shown...
D000678;D000069196;D048271;D009369
T121;T007;T109;T191;T001
36,291,722
antidepress drug sertralin human cancer cell use fda approv drug new indic repres faster econom way find novel therapeut agent cancer therapi compar develop new drug repurpos drug advantag pharmacolog context sinc drug alreadi extens data relat pharmacokinet facilit approv process differ diseas sever studi report promi...
D020280;D009369
T121;T191;T109
36,291,721
cardioprotect mechan leonurin myocardi ischemia liver cardiac crosstalk metabolom studi leonurin shown excel anti myocardi ischemia effect previous studi suggest cardiac protect leonurin myocardi ischemia appear inextric link regul liver present howev mechanist studi leonurin regul hepat metabol ischem injuri studi met...
D003324;D017202
T047
36,291,720
pten protein phosphatas activ requir tumour suppress mous prostat loss pten function one common event drive aggress prostat cancer biochem pten lipid phosphatas oppos activ oncogen pik akt signal network howev pten also addit potenti mechan action includ protein phosphatas activ use mutant enzym pten yl select lack pro...
D011471;D051059
T191;T126;T116
36,291,719
effect posit charg distribut cryoprotect activ dehydrin dehydrin intrins disord protein express ubiquit throughout plant kingdom respons desicc dehydrin found cryoprotect effect lactat dehydrogenas ldh vitro larg part influenc hydrodynam radius rather order amino acid within sequenc altern may sequenc specif effect how...
D064267
T123;T116
36,291,718
isol character hydroxi trimethyl oxo cyclohexen acet acid metabolit bacteri transform abscis acid report discoveri new abscis acid aba metabolit found cours mass spectrometr studi aba metabol rhizospher bacterium rhodococcus sp py analogu aba enrich tritium cyclohexen moieti fed bacteri cell extract contain radioact me...
D000040;D019342
T123;T121;T130;T109
36,291,717
dna replic mechan explain structur variat pigeon recess red locus speci adapt environ evolut must act upon genet variat present popul elucid molecular mechan give rise variat thus crucial import understand organ evolv addit variat caus point mutat structur variat delet duplic invers transloc also import sourc varieti m...
D010856;D004261
T045;T012
36,291,716
stereoselect membran transport phenylethylamin deriv human monoamin transport organ cation transport stereoselect well known pronounc drug metabol receptor bind howev much less known stereoselect drug membran transport character stereoselect cell uptak chiral phenylethylamin deriv human monoamin transport net dat sert ...
D027702;D009655
T123;T121;T116;T109
36,291,715
addit natur extract antioxid function preserv qualiti meat product antioxid use prevent oxid reaction inhibit develop unwant sensori characterist decreas nutrit qualiti accept shelf life process meat product improv stabil synthet antioxid although effici relat develop diseas present toxic carcinogen effect thus researc...
D000975;D008461
T123;T121;T168;T039;T044
36,291,714
divers composit role mirna non neuron cell neuron synaps alzheim diseas neuron interact astrocyt microglia vascular cell interact becom unbalanc diseas state result damag neuron synaps contribut cognit impair import synapt loss synapt dysfunct consid year main patholog factor cognit impair alzheim diseas ad recent mirn...
D000544;D035683
T123;T047;T114;T048
36,291,713
high resolut ribosom profil reveal gene specif detail uga code selenoprotein biosynthesi co translat incorpor selenocystein sec selenoprotein occur uga codon process translat elong compet translat termin selenocystein insert sequenc bind protein secisbp great enhanc sec incorpor selenoprotein interact mrna ribosom elon...
D017279;D004251
T123;T116;T114;T086
36,291,712
pancreat cancer research beyond dna mutat pancreat ductal adenocarcinoma pdac caus genet mutat four gene kras proto oncogen gtpase kras tumor protein p tp cyclin depend kinas inhibitor cdkna mother decapentapleg homolog smad also call big chang tumor complex make character earli stage challeng therefor develop innov th...
D055549;D010190;D021441
T191;T109
36,291,711
blood adipokinescytokin young peopl chronic bronchiti abdomin obes pathogenesi develop chronic lung diseas assum particip system inflamm factor well hormon like substanc produc adipos tissu aim studi evalu associ certain adipokinescytokin chronic bronchiti background abdomin obes young peopl studi includ peopl age tota...
D054392;D029481
T123;T047;T116
36,291,710
mechan periton mesotheli cell periton adhes periton adhes pa fibrot tissu connect abdomin viscer organ peritoneum format pas induc varieti clinic diseas howev current effect strategi prevent treatment pas damag periton mesotheli cell pmcs believ caus pas promot inflamm fibrin deposit fibrosi format earli stage pa forma...
D010537;D005109
T023;T024
36,291,709
high intens exercis train improv basal platelet prostacyclin sensit potenti respons dual anti platelet therapi postmenopaus women risk thrombot event dramat increas age may acceler women cessat endogen estrogen product menopaus patient risk thrombosi prescrib dual anti platelet therapi dapt aspirin py antagonist encour...
D011464;D013927
T123;T046;T121;T109
36,291,708
differenti effect beta hydroxybutyr enantiom induc pluripot stem deriv cardiac myocyt electrophysiolog beta hydroxybutyr ohb along acetoacet aceton liver produc keton bodi increas fast prolong exercis altern fuel sourc glucos ohb main circul keton bodi g protein coupl receptor ligand also histon deacetylas inhibitor pr...
D032383;D000090
T025;T109
36,291,707
construct analysi enzym constrain metabol model corynebacterium glutamicum genom scale metabol model gem power tool interpret predict cellular phenotyp various environment genet perturb howev gem consid stoichiometr constraint simul growth product yield valu show monoton linear increas increas substrat uptak rate devia...
D048230
T007
36,291,706
drug diseas associ predict use heterogen network comput drug reposit drug reposit involv identif new therapeut indic approv drug consider reduc time cost develop new drug recent comput drug reposit method use heterogen network identifi drug diseas associ review reveal exist network base approach predict drug diseas ass...
D058492;D019295
T062;T091;T061
36,291,705
prognost valu high sensit cardiac troponin women high sensit cardiac troponin assay becom gold standard diagnos acut chronic myocardi injuri detect troponin level beyond th percentil includ fourth univers definit myocardi infarct specif recommend use sex specif threshold measur concentr propos diagnost threshold shown ...
D063507;D054058
T047;T054
36,291,704
editori special issu hyaluron acid human medicin hyaluron acid ha acid non sulfat glycosaminoglycan intens studi biodegrad biocompat materi scaffold regen medicin clinic applic
D006820;D001672
T123;T122;T121;T109
36,291,703
crystal structur human copper chaperon atox bound zinc ion bioavail copper cu human cell may depend complex interplay zinc zn ion investig abil zn ion target human cu chaperon atox small cytosol protein capabl anchor cu conserv surfac expos cys x x cys cxxc motif deliv cu transport atpas tran golgi network crystal stru...
D056511;D003300
T123;T196;T121;T116
36,291,702
gene deliveri manf beta cell pancreat islet protect nod mice type diabet develop type diabet dysfunct glucos regul occur due death insulin produc beta cell pancreat islet initi process caus inherit adapt immun system predispos respond beta cell antigen notabl insulin coupl unknown environment insult prime autoimmun rea...
D003922;D003924;D007515
T047;T023
36,291,701
compar analysi mesophil yqfb type amidohydrolas widespread superfamili human activ signal cointegr homolog asch domain identifi almost year ago howev amount experiment data regard biolog function domain scarc studi aim determin putat cellular function four hypothet asch domain contain amidohydrolas yqfb analogu investi...
D000581;D011355
T120;T126;T116
36,291,700
qualiti evalu ophiopogon japonicus two authent geograph origin china base physicochem pharmacolog properti polysaccharid ophiopogon japonicus wide use tonic herb china accord origin maidong chines materia medica classifi zhe maidong ophiopogon japonicus zhejiang chuan maidong ophiopogon japonicus sichuan duant maidong ...
D031441;D008419
T121;T002
36,291,699
combin antimalari cns drug antineoplast agent mcf breast ht colon cancer cell biosafeti evalu mechan action drug combin drug repurpos two strategi allow find novel oncolog therapi faster econom process previous studi develop novel model drug combin use antineoplast differ repurpos drug demonstr combin doxorubicin dox a...
D000962;D000970;D001943;D003110
T121;T191;T109
36,291,698
current challeng biolog treatment pharmaceut base contamin oxidoreductas enzym immobil process real aqueous matric hybrid techniqu worldwid access pharmaceut continu releas environ rais serious global concern pharmaceut remain activ even low concentr therefor occurr waterbodi may lead success deterior water qualiti adv...
D060766;D014874
T131;T167
36,291,697
lipidom reveal plasma phospholipid profil differ deceas recov covid patient thorough understand metabol chang includ lipidom alter associ develop covid appear crucial new type coronavirus still report studi analyz differ plasma phospholipid profil deceas covid patient recov healthi peopl due identifi abnorm plasma phos...
D010743;D000086382
T123;T047;T067;T109
36,291,696
identif biolog function prognost valu nnmt oral squamous cell carcinoma nicotinamid n methyltransferas nnmt metabol enzym catalyz methyl nicotinamid nam generat methyl nicotinamid mnam although previous studi shown nnmt frequent dysregul promot onset progress mani malign express profil prognost valu function oral squam...
D009062;D002294;D006258
T191
36,291,695
function tune intrins disord region human protein composit bias intrins disord region idr protein sequenc flexibl low structur constraint result faster rate evolut lack evolutionari conserv great limit use sequenc homolog classif function assess idr oppos globular domain studi idr requir properti classif function predi...
D064267
T123;T116
36,291,694
methylsulfonyl hexyl isothiocyan chemoprevent agent induc autophagi leukemia cell line autophagi fundament catabol process cellular surviv role autophagi cancer high complex earli stage neoplast transform act tumor suppressor avoid accumul protein damag organell reactiv oxygen speci ros advanc stage cancer autophagi ex...
D054697;D007938
T121;T191
36,291,693
effect atomoxetin motor cognit behavior brain electrophysiolog activ dopamin transport knockout rat chang dopaminerg noradrenerg transmiss consid under caus attent deficit hyperact disord adhd atomoxetin atx select norepinephrin transport net inhibitor current use adhd treatment studi aim evalu effect atomoxetin behavi...
D050483;D050484
T123;T116;T192
36,291,692
identif molecular subtyp novel prognost model sepsi base ferroptosi associ gene signatur ferroptosi recent associ immunolog chang sepsi howev clinic signific ferroptosi associ gene fag remain unknown paper fag base prognost model construct sepsi patient use integr machin learn approach prognosi model compos fag classif...
D000079403;D018805
T047;T046;T043
36,291,691
effect one year tofacitinib therapi lipid adipokin associ vascular pathophysiolog rheumatoid arthriti cardiovascular cv morbid mortal metabol syndrom associ rheumatoid arthriti ra recent trial suggest increas risk major cv event mace upon janus kinas jak inhibitor tofacitinib compar anti tumor necrosi factor tnf therap...
D001172;D000075242
T121;T047
36,291,690
prognost impact relat lipid profil patient myocardi infarct prospect cohort studi background vivo studi show inhibit progress atherosclerosi predict lower risk recurr ischemia patient acut myocardi infarct ami could mediat modul lipid metabol current studi aim investig effect various lipid content prognost impact patie...
D000071449;D009203
T047;T126;T116
36,291,689
exom sputum microbiota predict marker frequent exacerb chronic obstruct pulmonari diseas frequent acut exacerb lead caus high rate hospit mortal chronic obstruct pulmonari diseas copd despit enorm worldwid medic burden reliabl molecular marker effect earli diagnosi prognosi acut exacerb still lack host genet airway mic...
D029424;D064307
T001;T047;T032;T028
36,291,688
quantifi coexist concentr multi compon phase separ system use analyt hplc last decad evid accumul suggest numer instanc cellular compartment explain phenomenon phase separ process macromolecular solut separ spontan dens dilut coexist phase semi quantit vitro approach measur phase boundari proven use determin key featur...
D002851
T059
36,291,687
intercellular communic reveal therapeut potenti epitheli mesenchym transit tripl negat breast cancer background tripl negat breast cancer tnbc aggress subtyp breast cancer high intra tumor heterogen epitheli mesenchym transit emt one induc cancer metastasi migrat howev descript emt process tnbc use singl cell rna seque...
D058750;D064726
T191;T043
36,291,686
mmp uch l proteasom potenti biomark support diagnosi brain glioma diagnosi brain glioma main base imag method gold standard area mri recommend prevent diagnosi treatment glioma period modifi updat one diagnost techniqu use brain glioma suspect liquid biopsi howev techniqu requir develop confirm effect paper present pro...
D043222;D005910
T191;T126;T116
36,291,685
compar genom analysi uncov chloroplast genom variat phylogenet relationship camellia speci camellia largest genus famili theacea due phenotyp divers frequent hybrid polyploid understand phylogenet relationship camellia speci remain challeng compar chloroplast cp genom provid inform resourc phylogenet analys camellia st...
D054628;D028244
T002;T028