PMID
int64 35.7M
36.4M
| Title/Abstract
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36,282,859
|
sleep relat hallucin patient parkinson diseas given sleep wake cycl dysfunct caus hallucin parkinson diseas patient sleep relat hallucin may differ subtyp hallucin occur full wake howev studi distinguish onset situat hallucin relat sleep occur full wake conduct investig hallucin parkinson diseas patient therefor conduct multicent observ studi investig preval factor associ sleep relat hallucin patient parkinson diseas inform hallucin collect use questionnair face face interview consecut patient parkinson diseas report sleep relat hallucin report hallucin full wake longer durat parkinson diseas treatment ci higher beck depress inventori ii score ci higher rapid eye movement sleep behavior disord score ci independ factor associ presenc sleep relat hallucin multivari analysi sleep relat hallucin daytim hallucin associ probabl rapid eye movement sleep behavior disord phenomenolog discrimin sleep relat hallucin daytim hallucin import elucid full patholog parkinson diseas mechan under hallucin
|
D020187;D010300
|
T047;T048
|
36,282,858
|
peptid lv augment intermedi conduct calcium depend potassium channel kca endotheli cell promot angiogenesi peptid lv small endogen secretori peptid express various tissu conserv across differ speci patient diabet retinopathi ocular diseas patholog angiogenesi upregul peptid lv retina pro angiogen activ peptid lv part promot vascular endotheli cell ec prolifer migrat sprout molecular mechan complet understood studi aim deciph peptid lv promot ec depend angiogenesi use patch clamp electrophysiolog record western immunoblot quantit pcr cell prolifer assay cultur ec endotheli cell treat peptid lv becam signific hyperpolar essenti step ec activ treatment peptid lv augment express current densiti intermedi conduct calcium depend potassium kca channel contribut ec hyperpolar augment potassium channel block kca attenu peptid lv elicit ec prolifer result indic peptid lv stimul increas function kca ec contribut ec activ ec depend angiogenesi
|
D042783;D051660
|
T123;T116;T025
|
36,282,857
|
rapid visual candidatus liberibact asiaticus detect citrus green diseas use simpl alkalin heat dna lysi follow loop mediat isotherm amplif coupl hydroxynaphthol blue al lamp hnb potenti local use outbreak citrus green huanglongb diseas bacteria occur mani area sampl identifi ongo year orang tree endem northern thailand candidatus liberibact asiaticus therebi develop plant green diseas c liberibact asiaticus detect assay use simpl alkalin heat dna lysi loop mediat isotherm amplif coupl hydroxynaphthol blue al lamp hnb evalu develop assay feasibl point care detect plant leaf sampl copi c liberibact asiaticus mock inject compar commerci dna lysi kit pcr ge assay sensit copi omp equal fg compat pcr ge limit detect ultra sensit limit detect could allow diseas detect clinic appar state diseas c liberibact asiaticus infect number ie fewer copi c liberibact asiaticus assay also specif degener primer target everi strain c liberibact asiaticus omp genbank databas rapid min total assay time inexpens usdreact requir sophist instrument compar assay accuraci accuraci specif sensit bacteri dna extract commerci kit follow pcr gel electrophoresi accuraci specif sensit base real sampl test henc techniqu could use local laboratori resourc restrict set test result could read nake eye color chang violet negat sky blue posit c liberibact asiaticus infect specimen furthermor assay use safe chemic reagent thus safe user
|
D002957;D012230
|
T168;T007;T002
|
36,282,856
|
comparison low salt prefer trend region variat patient major non communic diseas general popul compar low salt prefer patient major chronic diseas also known non communic diseas hereinaft refer major ncd patient general popul
|
D000073296;D003920
|
T047
|
36,282,854
|
pairwis randomis control trial peer mediat play base intervent improv social play skill children adhd outcom typic develop playmat examin effect play base intervent improv social play skill typic develop playmat children adhd children year randomis intervent n waitlist control group n test play score blind rater group statist compar chang intervent week intervent waitlist control week wait group chang intervent group follow intervent signific greater chang waitlist control group combin data group playmat n mean top score improv signific follow intervent larg effect pre post intervent pre intervent follow typic develop playmat children adhd benefit particip peer mediat intervent
|
D001289;D009788
|
T061;T048
|
36,282,853
|
psycholog impact cope behavior traumat stress among healthcar worker covid taiwan earli stage experi studi investig psycholog impact cope behavior traumat stress experienc healthcar worker earli stage covid pandem formul effect support strategi implement hospit govern policymak help healthcar staff overcom pandem
|
D000086382
|
T047;T067
|
36,282,852
|
cantones lexic tone inform import sentenc recognit accuraci quiet nois chines languag tone use express lexic mean word therefor import analyz role lexic tone chines sentenc recognit accuraci lack research role cantones lexic tone sentenc recognit accuraci therefor studi examin contribut lexic tone inform cantones sentenc recognit accuraci cognit correl adult normal hear nh text speech synthesi engin use synthes cantones daili use sentenc word carri origin flat lexic tone present particip quiet speech shape nois ssn two talker babbl ttb nois condit target sentenc nois present db binaur via insert headphon found listen nh almost perfect recogn daili use cantones sentenc mismatch lexic tone inform quiet sentenc recognit decreas substanti nois find report mandarin relat simpl tonal system suggest current result may applic tonal languag addit work memori wm signific relat declin sentenc recognit score ttb ssn lexic tone mismatch find explain use eas languag understand model suggest higher wm less like affect degrad lexic inform perceiv daili use sentenc ttb
|
D007802;D013067
|
T171;T041
|
36,282,850
|
season variat nutrit valu fifteen multipurpos fodder tree speci case studi north western himalayan mid hill multipurpos tree speci recogn import fodder sourc livestock potenti remain untap due dearth knowledg nutrit valu therefor mpts ie acacia catechu albizia chinensi bauhinia variegata celti australi ficus roxburghii grewia optiva leucaena leucocephala melia composita morus serrata olea glandulifera ougienia oojeinensi pittosporum floribundum quercus glauca q leucotrichophora salix tetrasperma evalu nutrit characterist relat nutrit valu index rnvi palat index farmer prefer season basi north western himalaya mid hill nutrit miner content decreas leav matur except ether extract calcium copper organ matter carbohydr content cell wall constitu anti nutrit content increas overal serrata highest rnvi spring summer g optiva autumn winter similar l leucocephala highest palat composita lowest one addit g optiva favor mpt livestock among farmer composita least one outcom studi help polici maker planner farm manag establish larg scale plantat high nutriti palat speci like g optiva l leucocephala b variegata serrata year round suppli green leav supplement low qualiti feed
|
D014197;D007887
|
T002
|
36,282,849
|
data platform open life scienc systemat analysi manag instrument open data platform interfac data demand suppli user yet data platform provid frequent struggl aggreg data suit user need establish high intens data exchang collabor environ use open life scienc data platform exampl divers data structur systemat categor platform base technolog intermedi rang domain cover deriv general specif success factor manag instrument qualit content analysi base depth interview expert employ data platform extern stakehold thus complement peer initi focus sole data qualiti addit highlight data platform role enabl data util innov output base analysi propos clear structur detail guidelin seven manag instrument guidelin help establish operation data platform best exploit data provid find support exploit open innov potenti life scienc beyond
|
D001690
|
T090
|
36,282,846
|
distinct share b cell respons tuberculosi patient household contact studi aim identifi b cell respons could distinguish latent tuberculosi infect ltbi activ tb diseas studi subject smear posit tb patient n diseas free household contact hhcs n sera use determin antibodi level od valu mycobacterium tuberculosi membran mtm antigen elisa visualis seroreact mtm antigen immunoblot b cell subset whole blood sampl determin flow cytometri tb sera level igg antibodi signific higher igm iga wherea igm iga antibodi level compar convers hhc sera signific higher igm antibodi level igg iga ratio igm igg antibodi hhcs also signific higher patient immunoblot reveal mtm antigen kda react tb well hhc sera wherea antigen kda react tb subset hhc sera frequenc classic memori b cell cmbcs cdcd signific higher igg cmbcs signific lower hhcs patient frequenc iga cmbcs hhcs patient compar signific higher correspond frequenc igg cmbcs frequenc iga atyp mbcs ambc cdcd hhcs patient also compar signific higher igg ambc plasmablast cdcdcd frequenc hhcs patient compar result suggest igmigg antibodi ratio antibodi bind select mtm antigen relat frequenc mbc subset could indic protect pathogen immun respons follow primari infect mtb respons orchestr protect lead quiescent ltbi may provid clue effect vaccin strategi tb
|
D014376;D009169;D055985
|
T047;T007
|
36,282,845
|
il mtorc signal coordin statt bet axi ensur th cell differenti anti bacteri immun respons fish util special th cell resist intracellular pathogen infect repres import innov adapt immun although transcript evid indic potenti presenc th like cell fish speci exist cdcdifn cell detail function mechan determin differenti earli vertebr remain unclear present studi identifi popul cdcd ifn th cell nile tilapia upon cell activ vitro edwardsiella piscicida infect vivo deplet cd cell block ifn th cell produc ifn found essenti tilapia activ macrophag resist e piscicida infect mechanist activ cell tilapia produc il enhanc stat mtorc signal turn trigger statt bet axi control ifn transcript th cell develop addit mtorc regul differenti cell promot prolifer cdcd cell moreov ifn bind receptor ifnr ifnr initi statt bet axi mediat posit feedback loop stabil th cell polar tilapia find demonstr prior emerg tetrapod boni fish nile tilapia alreadi evolv th cell fight intracellular bacteri infect support notion il mtorc signal coordin statt bet axi determin th cell fate ancient mechan program earli vertebr evolut studi expect provid novel perspect evolut adapt immun
|
D018417;D016587
|
T120;T039;T025
|
36,282,844
|
rapid detect hepat c virus use recombinas polymeras amplif million peopl infect hepat c virus hcv worldwid approxim global death result complic untreat chronic hcv pan genom direct act antivir daa recent becom wide avail featur high cure rate less week treatment rollout daa reliant diagnost test hcv rna identifi elig patient virem hcv infect current pcr base hcv rna assay restrict well resourc central laboratori remain prevail clinic need expand access decentr hcv rna test provid rapid chronic hcv diagnosi linkag daa outpati clinic paper report rapid high accur minim instrument assay hcv rna detect use revers transcript recombinas polymeras amplif rt rpa assay detect hcv genotyp limit detect copi per reaction genotyp preval unit state worldwid clinic sensit specif rt rpa assay evalu use divers clinic serum specimen accuraci short runtim low heat demand rt rpa may enabl implement point care hcv test expand global access effect treatment via rapid chronic hcv diagnosi
|
D019698;D006526
|
T047
|
36,282,842
|
methodolog classifi tissu specif metabol inflammatori receptor function appli subcutan viscer adipos achiev homeostasi human biolog system reli interact organ bind ligand secret sourc organ receptor locat destin organ current chang role receptor perform tissu partial understood recent methodolog base receptor co express pattern classifi tissu specif metabol function suggest present advanc framework predict addit class inflammatori receptor use featur space biolog pathway enrich analysi score co express network eigengen correl fed three machin learn classifi extrem gradient boost xgboost support vector machin svm k nearest neighbor k nn appli methodolog subcutan viscer adipos gene express dataset deriv gtex genotyp tissu express project compar predict xgboost model demonstr best perform predict pre label receptor accuraci subcutaneousviscer adipos analyz receptor predict eight new metabol new inflammatori function receptor four new metabol function known inflammatori receptor adipos tissu cross referenc multipl predict use publish literatur result establish pictur chang function receptor two adipos tissu benefici drug develop
|
D000273;D040521
|
T201;T024
|
36,282,841
|
intra articular inject epigallocatechin egcg crosslink alter biomechan properti articular cartilag studi via nanoindent osteoarthr rheumatoid arthriti debilit condit affect million peopl osteoarthr rheumatoid arthriti degrad articular cartilag ac end long bone result weaken tissu prone damag degrad impair cartilag mechan properti lead area thin cartilag expos bone compromis integr joint prevent measur exist joint destruct discov way slow degrad ac prevent would slow pain progress diseas allow million live pain free recent articular inject polyphenol epigallocatechin gallat egcg slow ac damag arthriti rat model suggest egcg crosslink ac make resist degrad howev direct evid intraarticular inject egcg crosslink cartilag collagen chang compress properti known aim studi investig effect intraarticular inject egcg induc biomechan properti ac hypothes vivo exposur egcg bind crosslink ac collagen alter biomechan properti develop techniqu nano indent investig articular cartilag properti measur cartilag compress properti quantifi differ due egcg exposur studi rat knee joint subject seri intraarticular inject egcg contralater knee joint inject salin inject anim sacrif knee remov test anatom relev model nanoindent mechan data normal measur contralater knee better compar data anim data demonstr signific increas reduc elast modulus hard stiff cartilag treat inject egcg normal treat salin solut compar baselin subject without inject signific level alpha data provid evid egcg treat cartilag yield strengthen cartilag matrix compar ac salin inject knee find signific increas cartilag biomechan translat resist degrad arthriti furthermor data suggest first time possibl strengthen articular cartilag intraarticular inject polyphenol although data preliminari suggest clinic applic egcg treat cartilag could yield strengthen tissu potenti resist compens matrix degrad caus arthriti
|
D002358;D010003;D001172
|
T047;T024
|
36,282,840
|
improv surviv non small cell lung cancer patient introduc patient navig retrospect cohort studi propens score weight histor control onkonetwork patient navig program establish moritz kaposi general hospit improv timeli complet cancer investig treatment h selfi consortium select onkonetwork promis integr care initi hungari conduct multicriteria decis analysi base health patient experi cost outcom paper detail analysi clinic impact provid largest subgroup non small cell lung cancer nsclc patient retrospect cohort studi conduct enrol new cancer suspect patient subsequ confirm nsclc two annual period onkonetwork implement control intervent cohort respect control select bias confound baselin balanc improv via propens score weight overal surviv analyz univari multivari weight cox regress model effect character counterfactu analysi analysi includ intervent control nsclc patient earli advanc stage signific cohort baselin differ propens score base weight result good baselin balanc larg surviv benefit observ intervent cohort intervent independ predictor longer surviv multivari analysi baselin characterist includ hr p post baselin variabl includ model belong intervent cohort independ predictor surviv surviv benefit explain slight better stage distribut ecog status treatment initi togeth trend broader use pet ct higher resect rate conclus patient navig valuabl tool improv cancer outcom facilit time complet cancer diagnost contradictori evid literatur may explain common sourc bias includ wait time paradox adjust intermedi outcom
|
D002289;D008175;D062526
|
T058;T191;T097
|
36,282,839
|
vector compet lambda cyhalothrin resist aed aegypti strain dengu zika chikungunya virus colombia aed aegypti primari vector dengu zika chikungunya virus studi shown insecticid resist affect vector compet vc mosquito speci studi evalu effect resist lambda cyhalothrin kdr vi mutat genotyp vc ae aegypti strain denv zikv chikv three ae aegypti strain gradual lambda cyhalothrin resist suscept resist high resist infect denv zikv chikv individu mosquito test detect virus infect abdomen head salivari gland use rt pcr genotyp vi mutat use allel specif pcr record vc variabl midgut infect rate mir dissemin rate dir dissemin effici die lambda cyhalothrin resist affect differenti vc variabl zikv denv chikv zikv appar gradual increas dir die increas insecticid resist observ denv mir die higher insecticid resist strain chikv mir could evalu variabl higher insecticid resist strain presenc kdr vi mutat mosquito resist strain affect vc variabl three studi virus
|
D000330;D000071244;D002646;D000071243;D065632;D003715
|
T005;T204;T047
|
36,282,838
|
cancer patient experi diagnosi treatment incident pulmonari embol qualit studi diagnosi symptomat cancer associ thrombosi often caus distress alarm patient especi unawar risk sign symptom look data cancer patient experi incident diagnos pulmonari embol ipe lack warn recognis sign symptom may caus delay diagnosi aggrav distress
|
D011655;D009369
|
T047;T046;T191
|
36,282,837
|
time changin longitudin mix method case studi hospit transform chang hospit infrastructur inevit ever evolv healthcar system redevelop hospit open new build complex challeng time staff must find way deliv safe high qualiti care navig complex uncertainti chang studi explor perspect experi staff patient open new hospit build part larg public hospit redevelop sydney australia
|
D006779;D011787
|
T169;T058;T073;T093
|
36,282,836
|
head cervic postur correl malocclus systemat review meta analysi associ head cervic postur malocclus studi mani year despit extens encourag research conclus evid reach clinic applic
|
D008310
|
T033;T078;T190
|
36,282,835
|
work relat stressor mental health among lgbtq worker result cross section survey lesbian gay bisexu transgend queer lgbtq individu experi high rate advers mental health outcom due stressor experi famili communiti societi broad work workplac potenti influenc outcom given abil amplifi minor stress abil influenc social econom wellb alreadi margin popul studi aim identifi sociodemograph characterist characterist work includ degre precar industri perceiv workplac support lgbtq peopl influenc self report mental health among lgbtq peopl two canadian citi
|
D008603;D000072339
|
T098;T041
|
36,282,834
|
strengthen patient triag communiti pharmaci cluster randomis control trial evalu clinic impact minor ailment servic self perceiv minor ailment might conceal health condit patient appropri assist health care profession aim studi evalu patient relat outcom communiti pharmaci minor ailment servic mas compar usual pharmacist care uc
|
D010594;D003157
|
T058;T073;T093
|
36,282,832
|
advers effect inbreed transgener express herbivor induc defens trait solanum carolinens addit direct induc physic chemic defens herbivori experienc plant one generat influenc express defens trait offspr plant defens phenotyp compromis inbreed evid advers effect extend transgener express induc resist explor inbreed status matern solanum carolinens plant influenc transgener effect herbivori defens trait herbivor resist offspr manduca sexta caterpillar use damag inbr outbr carolinens matern plant cross pollin perform produc seed herbivor damag undamag inbr outbr matern plant seed grown greenhous assess offspr defens relat trait ie leaf trichom internod spine volatil organ compound resist herbivor found feed sexta caterpillar matern plant posit influenc trichom spine product offspr caterpillar develop offspr herbivor damag matern plant delay relat offspr undamag plant offspr inbr matern plant reduc spine product compar outbr matern plant caterpillar perform better offspr inbr plant herbivori inbreed matern generat alter volatil emiss offspr general matern plant inbreed dampen transgener effect herbivori offspr defens trait herbivor resist taken togeth studi demonstr induc defens carolinens persist across generat inbreed compromis transgener resist carolinens
|
D032322;D055549
|
T002;T109
|
36,282,818
|
knowledg distil multi depth model fusion recommend algorithm recommend algorithm save lot valuabl time peopl get inform interest howev featur calcul extract process machin learn deep learn recommend algorithm differ obtain various featur differ dimens ie integr advantag model improv model infer effici becom focus paper paper better deep learn model obtain integr sever cut edg deep learn model meanwhil make integr learn model converg better faster paramet integr modul initi constraint impos new activ function design better integr sub model final integr larg model distil knowledg distil great reduc number model paramet improv model infer effici
|
D000465;D000069550
|
T170;T066
|
36,282,817
|
sex risk factor occurr sever infecti parasit diseas dog protocol systemat review biolog sex import risk factor occurr sever infecti parasit diseas although various studi review describ sex differ infecti diseas human wildlif laboratori anim littl focus biolog sex risk factor infecti parasit diseas domest anim aim identifi synthesis evid dog hypothesi biolog sex gonadectomi status determin occurr sever diseas across taxa pathogen systemat review follow prefer report item systemat review meta analys prisma guidelin search web scienc scopus pubm peer review studi publish english databas incept studi design infecti parasit diseas dog includ review includ outcom preval incid infect diseas sever diseas measur case fatal time death recoveri hospitalis time pathogen burden eg viral load parasitaemia relev clinicopatholog paramet two review joint assess first record three databas subsequ one review screen remain record second review verifi record exclud first review full text includ record retriev assess elig first review author second author review record exclud first author risk bias individu studi assess use risk bias assess tool nonrandom studi synthesis inform studi present narrat text find present outcom type also group pathogen type evid sex specif effect expand understand infecti diseas pathogenesi under mechan may import implement diseas control intervent
|
D009784;D016273;D010272
|
T047;T037
|
36,282,815
|
direct indirect cost attribut alcohol consumpt brazil alcohol consumpt main risk factor death disabl world popul year old relat caus death import econom impact health social secur system three million death attribut alcohol worldwid million dali brazil alcohol consumpt per inhabit liter preval abus consumpt
|
D000428;D017048
|
T081;T055
|
36,282,814
|
retail investor beat institut investor explan game stop stock price anomali paper studi relat inform cost retail investor sentiment asset price motiv studi model learn retail investor could move asset price away fundament valu model institut investor pessimist retail investor optimist ratio expect util inform ration uninform institut investor increas first decreas cost inform increas addit larg number retail investor promot substanti increas stock price model provid part explan unusu high stock price game stop earli retail investor cliqu confront institut investor
|
D040541;D058028
|
T170;T057
|
36,282,813
|
petrous bone contain high concentr osteocyt one possibl reason ancient dna better preserv bone character ancient dna fossil bone provid invalu inform genet past human anim popul studi aid enorm discoveri ancient dna relat well preserv petrous bone compar bone reason better preserv howev well understood examin hypothesi one reason better dna preserv petrous bone fresh petrous bone contain dna bone therefor determin concentr osteocyt cell occlud insid lacuna within petrous bone compar concentr bone domest pig use high resolut microct show concentr osteocyt lacuna inner layer pig petrous bone adjac otic chamber three time higher around lacuna per mm mastoid tempor bone around lacuna per mm well cortic bone femur around lacuna per mm size shape lacuna inner layer petrous bone similar femur also show pig petrous bone lacuna contain osteocyt use histolog stain dna therefor confirm signific expand upon previous observ osteocyt lacuna concentr petrous bone support notion one possibl reason better preserv ancient dna petrous bone bone initi contain least three time dna bone thus diagenesi dna like preserv petrous bone compar bone
|
D010011;D000072441
|
T123;T025;T114
|
36,282,812
|
sever predictor covid sar cov variant delta omicron period singl center studi outcom coronavirus diseas covid treatment improv due vaccin establish better treatment regimen howev emerg variant sever acut respiratori syndrom coronavirus sar cov caus covid correspond chang characterist diseas present new challeng patient manag studi aim analyz predictor covid sever caus delta omicron variant sar cov
|
D000086402;D000086382
|
T005;T067;T047
|
36,282,811
|
drastic reduct fals posit speci sampl insect intersect default output two popular metagenom classifi use high throughput sequenc recov short dna read mani speci wide appli biodivers studi either amplicon metabarcod shotgun metagenom read assign taxa use classifi howev differ reason result often contain mani fals posit focus reduct fals posit speci attribut classifi benchmark two popular classifi blastn follow megan bm kraken k analys shotgun sequenc artifici singl speci sampl insect reduc number misclassifi read combin output two classifi two differ way keep read attribut speci classifi intersect approach keep read assign speci classifi union approach addit appli analyt detect limit reduc number fals posit speci expect metagenom classifi use default paramet generat unaccept high number misidentifi speci ten bm hundr k fals posit speci necessarili phylogenet close belong differ order insect union approach fail reduc number fals posit intersect approach got rid addit analyt detect limit reduc number ca fals posit speci per sampl misidentif speci classifi hamper confid dna base method assess biodivers biolog sampl approach allevi problem straightforward signific reduc number report fals posit speci
|
D056186;D054892
|
T091;T028
|
36,282,810
|
influenc distal proxim muscl activ neural crosstalk previous research indic neural crosstalk asymmetr domin effector exert stronger influenc non domin effector vice versa recent hypothes influenc substanti proxim distal effector current investig design determin effect distal first dorsal inteross fdi proxim tricep brachii tbi muscl activ neural crosstalk twelv right limb domin particip mean age requir rhythmic coordin pattern isometr forc guid lissaj display particip perform trial distal proxim effector coher two effector group calcul use emg emg wavelet coher result indic particip could effect coordin goal coordin pattern regardless effector use howev spatiotempor perform accur perform task distal proxim effector forc distort quantifi harmon indic perturb occur non domin effector domin effector result also indic signific lower harmon non domin proxim effector compar distal effector current result support notion neural crosstalk asymmetr natur greater proxim distal effector addit emg emg coher result indic signific neural crosstalk occur alpha band hz higher valu observ proxim condit signific coher alpha band suggest influenc neural crosstalk occur subcort level
|
D007537;D018482
|
T023;T024;T042
|
36,282,809
|
attent deficit children attent deficit hyperact disord primari school age measur attent network test ant protocol systemat review meta analysi attent deficit among bothersom symptom attent deficit hyperact disord adhd date neurolog basi attent deficit fulli describ accord diagnost criteria adhd may result deficit various attribut attent specialist neuropsycholog diagnost method allow reliabl distinct primari attent disord etiolog adhd secondari problem may aris due co morbid protocol aim systemat review literatur evalu pattern attent common school age children either diagnos adhd high risk adhd measur neuropsycholog attent network test ant
|
D001289
|
T048
|
36,282,807
|
emerg multilevel select simpl spatial model evolut altruism theori evolutionari origin altruist behavior long histori becom canon part theori evolut nevertheless mechan allow altruism appear persist still incomplet understood well known howev spatial structur popul import determin theoret experiment studi much attent devot popul subdivid discret group studi typic impos structur dynam group hand instead present simpl individu base model altruist organ spontan self organ spatial separ coloni reproduc binari fission henc behav darwinian entiti right use softwar automat track rise fall coloni abl appli formal theori multilevel select thus quantifi within among group dynam reveal individu coloni inevit succumb defector within coloni tragedi common even altruism persist popul altruist coloni reproduc frequent drive less altruist one extinct evid coloni promot select altruism turn depend altruism exist select altruism henc involv kind evolutionari bootstrap emerg coloni also depend crucial length scale motil altruism competit reconfirm general relev scale social evolut also stress impact understood fulli light emerg eco evolutionari spatial pattern result also suggest emerg spatial popul pattern function start point transit individu
|
D000533;D005075
|
T045;T054
|
36,282,806
|
noth realli chang arizona patient experi methadon buprenorphin access covid understand patient experi feder regulatori chang govern methadon buprenorphin moud access arizona covid pandem
|
D002047;D000086382;D009293
|
T121;T067;T109;T047;T048
|
36,282,805
|
person continu gp care outpati specialist visit peopl type diabet cross section survey continu care particular import patient chronic condit type diabet td continu shown reduc overal health servic util among peopl diabet howev evid relat util outpati specialist servic norway lack aim studi investig continu gp care peopl td associ use outpati specialist health care servic
|
D010045;D003924
|
T047;T101
|
36,282,804
|
applic machin learn tool ultra sensit detect lipoarabinomannan plasmon grate biosensor clinic sampl tuberculosi tuberculosi one top ten caus death global lead caus death singl infecti agent erad tuberculosi epidem one top unit nation sustain develop goal earli diagnosi essenti achiev goal improv individu prognosi reduc transmiss rate asymptomat infect aim support goal develop rapid sensit diagnost use machin learn algorithm minim need expert intervent
|
D009169;D014376;D015374
|
T047;T007;T059;T075
|
36,282,803
|
data driven approach delin irrit zone epilepsi meg reliabl identif irrit zone iz prerequisit correct clinic evalu medic refractori patient affect epilepsi given complex meg data visual analysi epileptiform neurophysiolog activ high time consum might leav clinic relev inform undetect record analyz interict activ seven patient affect epilepsi vectorview neuromag success underw epilepsi surgeri engel ii visual mark local characterist epileptiform activ vis implement two stage pipelin detect interict spike delin iz first detect candid event peaki ica compon cluster event around spatio tempor pattern identifi convolut spars code use averag cluster event creat iz map comput amplitud peak peak peak ascend slope slope valid approach comput distanc estim iz vis slope peak border surgic resect area ra identifi spatiotempor pattern mimick under interict activ clusterspati cluster popul averag spike predict iz map averag distanc resect margin mm visual analysi mm slope mm peak consider sourc spread ascend slope provid iz closer ra resembl analysi expert observ valid perform data driven approach autom detect interict spike delin iz comput framework provid basi reproduc bias free analysi meg record epilepsi
|
D015225;D004827
|
T060;T047;T033
|
36,282,801
|
ntp driven mechan nucleotid addit cycl escherichia coli rna polymeras transcript elementari step transcript catalyz e coli rna polymeras one two round nucleotid addit cycl nac resolv rapid kinet studi model stop flow kinet data pyrophosph releas coupl enzym assay one round nac indic rate pyrophosph releas signific less nucleotid incorpor upon model stop flow kinet data pyrophosph releas two round nac observ presenc next nucleotid incorpor increas rate releas first pyrophosph equival incorrect nucleotid incorpor effect rate pyrophosph releas although next nucleotid incorpor increas rate pyrophosph releas still signific less rate incorpor first nucleotid result stop flow kinet studi confirm use quench flow follow thin layer chromatographi qf tlc first nucleotid incorpor label gamma phosphat p monitor pyrophosph releas collect result consist ntp driven model nac bind next cognat nucleotid incorpor caus synergist conform chang enzym trigger rapid releas pyrophosph transloc enzym along dna templat strand nucleotid incorpor
|
D009711;D004926
|
T007;T114
|
36,282,800
|
hemoadsorpt critic ill final result intern cytosorb registri aim current paper summar result intern cytosorb registri data collect patient intens care unit primari endpoint actual hospit mortal compar mortal predict apach ii score main secondari endpoint sofa score inflammatori biomark overal evalu general condit patient enrol indic hemoadsorpt sepsissept shock n cardiac surgeri periop n cardiac surgeri postop n reason n apach ii predict mortal wherea observ hospit mortal overal sofa score chang cardiovascular pulmonari sofa score decreas point respect serum procalcitonin c reactiv protein level show signific reduct ngml mgl respect septic cohort pct il also show signific reduct ngml pgml respect evalu overal effect minim improv much improv much improv chang observ deterior signific differ primari outcom mortal improv cardiovascular pulmonari sofa score reduct pct crp il level trial registr clinicaltrialsgov identifi nct retrospect regist
|
D018805;D012772
|
T047;T046
|
36,282,799
|
cnap bridg centriol contact site maintain centrosom cohes centriol non membran bound organell particip fundament cellular process abil form physic contact structur interphas two matur centriol associ form singl centrosom phenomenon known centrosom cohes centrosom cohes import process cell migrat yet maintain unclear current model indic pericentriolar fibr term rootlet also known centrosom linker entangl maintain centriol proxim uncov centriol centriol contact site mechan centrosom cohes base coalesc proxim centriol compon cnap use live cell imag endogen tag cnap show proxim centriol form dynam contact respons physic forc cytoskeleton expans microscopi reveal cnap bridg contact site physic link proxim centriol nanoscal fluoresc correl spectroscopi fcs calibr imag show cnap accumul near micromolar concentr proxim centriol correspond hundr protein copi number ectop tether organell lysosom cnap form viscous cohes assembl promot organell spatial proxim result suggest mechan centrosom cohes cnap proxim centriol illustr non membran bound organell form organell contact site
|
D002502;D018385
|
T026
|
36,282,797
|
landscap alter checkpoint system myelodysplast syndrom implic prognosi emerg novel immunotherapi myelodysplast syndrom mds call profound character immunom bone marrow bm evalu prognost impact immunolog chang perform prospect studi mds patient refer tertiari hematolog center bone marrow donor relat studi cohort flow cytometri panel marker includ checkpoint ligand receptor use studi lymphoid myeloid subpopul bone marrow aspir studi found healthi donor mds patient high proport lymphocyt pd express respect high proport myeloid cell pd l express respect indic potenti physiolog role checkpoint system bm time complex alter includ pd ctla lag tim pathway accompani increas level reg myeloid deriv suppressor cell popul identifi bm mds patient cluster analysi show independ prognost signific checkpoint profil overal surviv hr ci p tim postiv nk cd effector cell along blast count key subpopul prognosi elev blast bone marrow associ simultan express multipl checkpoint myeloid cell
|
D000072597;D009190
|
T046;T191;T116;T192
|
36,282,795
|
gestat congenit syphili across intern border brazil brazil lack data syphili border area aim describ spatial tempor distribut acquir syphili pregnanc sp congenit syphili cs brazilian municip arch border context
|
D013590;D013587;D011251
|
T019;T047
|
36,282,794
|
explor spatial variat level predictor unskil birth attend deliveri bangladesh use spatial analysi techniqu find nation repres survey data bangladesh fail meet unit nation goal reduc matern mortal last decad high preval unskil birth attend uba deliveri result negat consequ health mother newborn babi countri spatial variat uba deliveri predictor yet explor bangladesh could help formul cost effect polici reduc studi examin spatial variat uba deliveri predictor bangladesh
|
D011295;D000068916
|
T081;T058
|
36,282,790
|
explor mass intern mass distribut singl carboxysom free solut use fluoresc interferometr scatter anti brownian trap carboxysom self assembl bacteri microcompart facilit carbon assimil coloc enzym co fixat within protein shell microcompart high heterogen composit fill measur mass load individu carboxysom would allow better character assembl function enabl detail extend character singl nanoparticl solut recent demonstr improv interferometr scatter anti brownian electrokinet isabel trap track posit singl nanoparticl via scatter near infrar beam appli feedback counteract brownian motion import scatter signal relat mass nanoscal proteinac object whose refract indic well character calibr singl particl scatter cross section measur isabel trap determin individu carboxysom mass mda rang analyz scatter cross section core shell model investig carboxysom load combin mass measur simultan fluoresc report label intern compon method may extend biolog object virus extracellular vesicl combin orthogon fluoresc report achiev precis physic chemic character individu nanoscal biolog object
|
D015388;D007368
|
T026;T059
|
36,282,782
|
neurolept sensit dementia lewi bodi use pimavanserin inpati set case report background antidopaminerg medic includ antipsychot known worsen motor neuropsychiatr symptom includ cognit psychosi patient dementia lewi bodi dlb intens worsen clinic symptom may vari result mortal certain situat report support clozapin quetiapin pimavanserin use psychosi control popul case report describ case year old man diagnosi dlb post treatment outcom olanzapin psychosi hospit experienc worsen cognit motor function discontinu olanzapin result resolut clinic worsen initi pimavanserin help treat hallucin return back baselin follow visit clinic month discharg incorpor use best practic alert bpa part electron health record ehr system help provid identifi patient prone neurolept sensit help select appropri medic treat psychosi patient popul conclus administr antipsychot patient parkinson especi dlb requir close clinic monitor judici use awar morbid mortal associ use import especi hospit experi incorpor use bpa help provid make judici choic treat patient popul pimavanserin fda approv psychosi parkinson diseas could potenti safe effect treatment option patient popul
|
D014150;D020961;D003024
|
T121;T039;T109;T047
|
36,282,778
|
secur protocol adapt covid elect surgeri thru medic personnel among popul infect morbid mortal covid pandem worldwid
|
D000086382
|
T047;T067
|
36,282,775
|
behavior demand pattern medic consult kidney diseas imss mortal chronic kidney diseas ckd increas particular america trend wich could also observ mexico main due magnitud diabet mellitus arteri hypertens reach main causal factor
|
D003920;D051436;D006973
|
T047
|
36,282,772
|
pharmacokinet safeti toler cariprazin pediatr patient bipolar disord schizophrenia object cariprazin dopamin prefer serotonin ht receptor partial agonist approv treat adult schizophrenia manicmix depress episod associ bipolar disord sequenti cohort dose escal studi first evalu pharmacokinet safeti toler profil cariprazin two major activ metabolit desmethyl cariprazin dcar didesmethyl cariprazin ddcar pediatr patient schizophrenia bipolar disord method phase open label studi enrol patient schizophrenia year age bipolar disord year age patient met diagnost statist manual mental disord fifth edit dsm criteria schizophrenia bipolar disord posit negat syndrom scale panss total score young mania rate scale ymrs total score patient assign one four treatment group receiv week cariprazin treatment slow titrat mgd fast titrat mgd pharmacokinet advers event ae various safeti paramet analyz efficaci evalu exploratori outcom result total particip enrol base mean trough level steadi state appear reach within week cariprazin dcar within week ddcar system exposur cariprazin dcar ddcar general increas approxim proport increas dose mgd frequent treatment relat treatment emerg ae includ sedat parkinson tremor dystonia blur vision improv baselin panss ymrs observ throughout treatment conclus first investig cariprazin pediatr popul schizophrenia bipolar disord pharmacokinet paramet consist observ adult cariprazin appear safe toler children adolesc
|
D001714;D012559;D014150
|
T121;T039;T048
|
36,282,771
|
week open label extens studi evalu safeti toler flexibl dose oral ziprasidon children adolesc bipolar disord recent episod manic object describ longer term effect safeti toler open label ziprasidon children adolesc bipolar disord bd method subset particip age year previous treat multi site week random control trial receiv open label ziprasidon mg twice day week result common advers event ae fatigu somnol nausea effect weight bodi mass index metabol paramet glucos cholesterol triglycerid minim particip fridericia correct qt interv msec chang baselin msec cardiac relat ae particip continu ziprasidon initi ziprasidon open label extens show improv symptom mania conclus overal find studi consist accumul knowledg safeti profil ziprasidon acut long term treatment children adolesc bd midst manic episod clinicaltrialgov id nct
|
D001714;D014150
|
T121;T039;T048
|
36,282,769
|
characterist correl metabol syndrom adolesc unipolar bipolar depress result cross nation inpati case control studi abstract object assess characterist correl metabol syndrom met adolesc major depress disord mdd bipolar disord depress episod bp method case control studi use nation inpati sampl data includ adolesc age year primari diagnosi mdd bp use propens score match base age sex raceethn extract case met follow condit obes diabet hypercholesterolemia hypertens control without met use multivari logist regress model calcul adjust odd ratio aor potenti correl met focus primari mood disord psychiatr comorbid result age sex raceethn match adolesc mdd bp compar n versus without met n met preval later age adolesc mean age year femal white black met character obes vs hypertens vs diabet vs hypercholesterolemia vs p met associ primari diagnosi bp versus mdd aor confid interv ci comorbid disrupt behavior disord dbd aor ci comorbid substanc use disord reduc met risk aor ci conclus adolesc mdd bp met associ primari bp diagnosi comorbid dbd met relat paramet screen earli adolesc depress spectrum disord aim prevent develop effect met
|
D001714;D003865;D024821;D006937;D006973
|
T047;T048
|
36,282,766
|
sensorimotor develop male femal rat subject neonat anoxia neonat hypox ischem encephalopathi hie one import reason morbid mortal term born infant hie impact earli somat neurolog motor develop includ social illustr damag sensorimotor system adapt valid model neonat anoxia use studi evalu sex differ wistar rat neurolog reflex motor develop suckl period short long term impair associ sex differ observ general anox male affect comparison control group anox femal long last effect injuri adolesc rat predomin affect male similar previous studi also found decreas number substantia nigra cell sex compar control far result indic hie caus neurobehavior alter asymmetr motor behavior brain damag possibl relat cognit impair previous observ adolesc alter may repres use endpoint studi efficaci potenti strategi may improv development consequ perinat asphyxia insult human
|
D020925
|
T047
|
36,282,765
|
matern stress develop infant attent threat relat facial express attent bias threat relat stimuli fear angri facial express import surviv emerg earli develop infant demonstr attent bias fear facial express month age attent bias toward anger year age modul experienti factor longitudin studi mother infant dyad famili predomin experienc low incom examin whether matern stress depress symptom associ trajectori attent bias threat assess attent disengag eye track task infant month old month infant demonstr general bias toward threat fear angri facial express matern perceiv stress associ trajectori bias toward angri facial express month specif infant mother higher perceiv stress exhibit greater bias toward angri facial express month decreas across next month compar infant mother lower perceiv stress display increas bias angri facial express age rang matern depress symptom stress life event associ trajectori infant attent bias anger fear find highlight role matern percept stress shape development trajectori threat alert system
|
D005149;D000070379
|
T033;T041
|
36,282,764
|
associ matern patern psychosoci stress infant hair cortisol among arab american immigr pilot studi accultur stress uniqu among immigr refer stress associ maintain cultur valu tradit host countri immigr parent confront psychosoci variabl accultur stress anxieti depress might result intergener negat consequ infant measur hair cortisol concentr hcc outcom neuroendocrin dysregul one relat noninvas approach gaug stress infant publish studi evalu associ among parent psychosoci variabl infant hcc among immigr famili therefor purpos studi examin relationship matern patern psychosoci stress variabl examin associ psychosoci variabl parent accultur stress anxieti depress infant hcc among immigr arab american famili sampl immigr arab american triad mother father infant recruit one home visit parent complet studi questionnair separ babi month old hair sampl collect infant hcc parent report signific symptom anxieti mother father depress mother father patern accultur stress anxieti depress symptom signific correl infant hcc accultur stress anxieti depress symptom signific correl mother father dyad futur research continu focus immigr famili includ parent better understand improv infant health
|
D006854;D054242
|
T125;T121;T098;T109
|
36,282,763
|
demograph health predictor telomer length adolesc telomer length tl propos play mechanist role exposom affect health outcom littl known tl adolesc development period precursor adult onset health problem often emerg examin health demograph sourc variat tl youth age demograph health inform includ age sex race household incom caregiv age marit status youth tobacco exposur bodi mass index pubert status health problem medic use season data collect genom dna extract saliva ts ratio comput follow qpcr age race season data collect household incom associ telomer singl copi ts ratio found ts ratio larger younger age among black youth saliva collect autumn winter among household higher incom analys stratifi race reveal associ age ts ratio present black youth season collect present across race famili demograph associ ts ratio vari race result provid inform futur telomer research highlight adolesc potenti import development phase racial dispar telomer shorten health
|
D059506;D016615
|
T026;T049
|
36,282,762
|
impact matern physic exercis inflammatori hypothalam pituitari adren axi marker brain lung prenat stress neonat mice studi aim evalu effect matern exercis alter induc prenat stress marker inflammatori process hypothalam pituitari adren axi brain lung neonat mice femal balbc mice divid three group control prenat restraint stress prenat restraint stress physic exercis gestat period day pnd pnd mice euthan brain lung analys gene express gr mr il il tnf brain lung protein express mmp lung analyz matern exercis reduc il il gene express brain pnd mice prenat stress matern exercis decreas gr mr il tnf gene express lung pnd mice hippocampus pnd femal exercis inhibit effect prenat stress express mr il il lung pnd femal exercis prevent decreas gr express caus prenat stress hippocampus lung pnd male prenat stress decreas gr gene express find confirm effect induc prenat stress demonstr physic exercis gestat period may protect role inflammatori chang
|
D010913;D011297
|
T022;T037
|
36,282,761
|
process task irrelev sound typic everyday activ children abil focus task ignor task irrelev stimuli critic effici cognit function attent control especi requir auditori modal sound privileg access percept conscious despit import function littl known auditori attent typic everyday activ childhood investig impact task irrelev sound attent three everyday activ play game read book watch movi activ environment novel sound present within sequenc standard sound year old children adult measur erp reflect earli sound process attent orient theta power evok standard novel sound activ play game versus read watch reduc earli encod sound children affect ongo inform process attent alloc group adult theta power reduc play mid central brain area result show pattern immatur neuron mechan under percept attent task irrelev sound year old children type activ affect process irrelev sound group earli stimulus encod process sensit type activ children
|
D001307;D004569
|
T060;T034;T041
|
36,282,760
|
matern stress mental health pregnanc offspr diurnal cortisol earli childhood current studi investig whether prepregn matern posttraumat stress disord ptsd symptom depress symptom stress predict children cortisol diurnal slope cortisol awaken respons car adjust relev variabl mother enrol deliv babi follow subsequ pregnanc year longitudin data subsequ child prospect design allow assess ptsd symptom depress symptom perceiv stress prior pregnanc children provid three saliva sampl per day three consecut day two timepoint earli childhood age year sd age year sd mother ptsd symptom prior pregnanc signific associ flatter child diurnal cortisol slope year child car find age year year remain statist signific adjust matern socioeconom status raceethn child age covari contrast matern prepregn depress symptom perceiv stress signific predict cortisol slope car result suggest matern prepregn ptsd symptom may contribut variat earli childhood physiolog studi extend earlier work demonstr risk advers outcom among children whose mother experienc trauma associ disentangl effect prenat mental health mother children earli childhood
|
D006854;D010913
|
T125;T121;T022;T109
|
36,282,759
|
develop anxieti like behavior adolesc persist effect adolesc morphin exposur male rat epidemiolog studi show preval opioid use misus abus adolesc impos social econom account worldwid chronic opioid exposur especi adolesc may last effect emot behavior persist adulthood current experi therefor design studi effect sustain opioid exposur adolesc anxieti like behavior adolesc male wistar rat underw increas dose morphin day pnds open field test oft elev plus maze epm test perform week postmorphin treatment adolesc adulthood moreov weight anim measur time point found chronic adolesc morphin exposur reduc weight gain period morphin treatment week signific effect locomotor activ anim moreov anxiolyt like behavior observ rat expos morphin adolesc evalu oft epm test thus long term exposur morphin adolesc profound potenti alter anxieti like behavior profil period adolesc adulthood matur nervous system affect drug abus development window adolesc effect may lead behavior stabl alter
|
D009020;D014151
|
T121;T039;T109
|
36,282,757
|
empathi other versus one child associ mother brain activ social cognit task toddler function caregiv higher disposit empathi tend children better development outcom howev studi consid role child direct ie parent empathi may relev caregiv child relationship hypothes mother parent empathi child infanc stronger predictor child social emot function toddler mother disposit empathi explor whether parent disposit empathi share distinct pattern neural activ social cognit movi watch task mother infant dyad greater parent empathi assess infant month old associ social emot compet fewer problem children year later even adjust disposit empathi contrast disposit empathi associ child function control parent empathi subset mother insula activ posit associ specif facet disposit parent empathi wherea right temporopariet junction activ associ parent empathi thus disposit parent empathi appear dissoci brain behavior metric parent empathi may viabl target intervent especi toddler risk develop social emot difficulti
|
D009035;D004645
|
T092;T099;T055;T054
|
36,282,756
|
lose parent earli life impair flock size discrimin lower oxytocin receptor abund medial amygdala homologu adult zebra finch experienc inadequ parent care earli life diminish adult social compet exampl low parent care impair adult socio cognit abil eg recogn familiar conspecif affili eg close social proxim outcom attribut diminish medial amygdala nonapeptid function rodent whether parent care effect beyond familiar sibl similar effect parent unclear zebra finch use explor parent andor sibl number shape adult recognit prefer small versus larg flock nonapeptid oxytocin vasotocin receptor express avian homologu mammalian medial amygdala chick rais singl mother father small brood pair parent small larg brood match singl parent chick per nest per parent respect pair rais bird prefer flock size adult bird rais singl parent equal prefer either size oxytocin receptor express lower bird rais singl parent versus pair parent vasotocin receptor level unaffect result highlight parent format anteced offspr social compet relat group size prefer nonapeptid mechan outcom influenc anim abil live social group
|
D046369;D063129
|
T051;T012
|
36,282,755
|
effect skin skin contact full term infant stress reactiv qualiti mother infant interact skin skin contact ssc mother infant benefici effect preterm full term infant under mechan larg unknown random control trial assess whether daili ssc full term mother infant dyad decreas infant cortisol behavior reactiv mild naturalist stressor facilit interact qualiti infant mother ie improv matern caregiv behavior mother infant adrenocort synchroni pregnant dutch women n recruit random alloc ssc care usual condit ssc condit perform h ssc daili birth postnat week week mother bath infant known mild stressor infant matern cortisol sampl baselin min bath infant matern behavior rate result indic effect ssc infant behavior cortisol reactiv bath session similar effect ssc found matern caregiv behavior mother infant adrenocort synchroni conclus find provid evid daili mother infant ssc associ full term infant behavior adrenocort stress reactiv mother infant interact qualiti futur studi replic find unveil potenti mechan under benefici effect ssc
|
D060127
|
T061
|
36,282,754
|
negat caregiv stress reactiv moder relat earli life stress extern adolesc exposur earli life stress el common implic develop psychopatholog import howev mani individu experi el develop emot behavior difficulti prior research implic stress exposur negat caregiv behavior pattern physiolog reactiv predict psycholog well howev precis factor contribut resili versus vulner advers effect stress exposur well understood longitudin studi adolesc n assess three timepoint approxim everi year begin age year examin role autonom reactiv social stress assess skin conduct trier social stress task negat caregiv behavior moder associ exposur el intern extern symptom found relat el extern symptom moder negat caregiv autonom reactiv relat el extern posit low level negat caregiv high level autonom reactiv interact predict intern symptom statist signific find highlight import consid physiolog environment variabl might contribut suscept resili symptom psychopatholog follow exposur el
|
D000076783
|
T033
|
36,282,753
|
sex differ vulner hippocampus prenat stress distress event pregnanc engag activ bodi endocrin stress respons link later life cognit deficit offspr associ development chang cognit control neural region interest prenat stress ps induc alter shown sex specif review literatur anim studi examin sex specif effect physic ps function structur hippocampus hippocamp impair like underli ps associ deficit learn memori furthermor connect hypothalam pituitari adren hpa axi hippocampus well heavi presenc glucocorticoid receptor grs hippocampus suggest structur play import role modul activ within stress circuitri sex specif pattern hope better understand sex specif ps relat hippocamp impair assist uncov molecular mechan behind sex base risk factor ps popul across develop perhap contribut greater precis manag cognit disturb vulner popul
|
D012727;D011297
|
T032;T037
|
36,282,752
|
physiolog matern sensit distress exploratori studi mother electrocort sympathet nervous system reactiv matern sensit respons infant distress relat number physiolog process includ electrocort activ activ sympathet nervous system sever studi examin system isol limit work date investig may moder one anoth relat matern behavior current exploratori studi aim investig interact effect late posit potenti lpp skin conduct level scl observ matern sensit distress nineti five mother month old infant particip two reactiv task measur lpp scl respons child cri stimuli matern sensit distress code video record mother infant interact result show signific interact effect lpp reactiv infant cri posit relat matern sensit distress among mother relat low scl reactiv find highlight import examin multipl system character physiolog basi matern behavior
|
D009035;D009034
|
T092;T099;T054
|
36,282,751
|
develop gut microbiom tempera infanc earli childhood systemat review tempera earli childhood good predictor later person behavior risk psychopatholog variat tempera explain environment biolog factor one biolog mechan interest gut microbiom gm associ mental physic health review synthes exist literatur evalu relationship gm composit divers tempera earli life web scienc psycinfo pubm scopus search data extract accord prisma guidelin total studi identifi six remain follow applic exclusioninclus criteria find suggest associ higher alpha divers tempera greater surgencyextravers high intens pleasur male lower effort control femal uniqu communiti structur beta divers found surgencyextravers male fear femal emerg pattern posit tempera trait associ gm communiti bias toward short chain fatti acid product metabol base dietari fiber complex carbohydr observ worthi investig gain deeper understand relationship futur research investig function aspect microbiom influenc diet
|
D013694;D000069196
|
T001;T007;T041
|
36,282,750
|
earli life experi sex influenc acoust repertoir use wild born hand rear captiv cheetah acinonyx jubatus earli depriv adult influenc known long last effect social abil notabl communic skill adult play key role guid regul behavior youngster includ acoust repertoir use speci vocal product learn cheetah grow alongsid mother month thus matern influenc develop social skill like crucial investig impact earli matern depriv vocal product use wild born cheetah rescu subsequ hand rear either earli less month later stage develop could distinguish sound type produc most singl sometim repeat multityp sound sequenc repertoir cheetah differ fundament describ studi adult cheetah statist analys reveal concurr effect earli experi sex repertoir use specif earli rear male character high proport purr meow stutter earli rear femal mew growl hoot sneez hiss late rear male meow mew growl howl late rear femal most meow studi demonstr therefor long term effect matern depriv communic skill limit vocal learner differenti effect accord sex line known social differ potenti differenti matern invest general emphas critic import consid past histori subject eg captivewild born motherhand rear earlyl mother depriv etc studi social behavior notabl acoust communic
|
D002612
|
T015
|
36,282,748
|
hormon behavior respons infant simul women without children investig impact matern status hormon reactiv behavior respons infant simul women primipar nullipar amount affection touch motheres analyz behavior measur caregiv saliva collect min interact infant simul analyz oxytocin testosteron cortisol estradiol level nullipar women also provid inform fertil motiv linear mix model indic greater use affection touch associ lower overal testosteron level cortisol decreas respons interact group primipar group amount affection touch associ invers cortisol level wherea nullipar group associ found oxytocin estradiol reactiv simul differ group hormon associ behavior higher fertil motiv nullipar women relat motheres lower testosteron level result indic simul elicit hormon reactiv mother nonmoth pattern associ caregiv behavior hormon level may partial differ result encourag use infant simul explor hormon process relat transit parenthood
|
D006854;D010121
|
T125;T121;T116;T109
|
36,282,747
|
associ parent involv bedtim young children even cortisol nighttim sleep parent theoriz play import role help young children downregul arous achiev suffici good qualiti sleep knowledg howev link parent children physiolog arous bedtim subsequ nighttim sleep empir test present studi examin year old children even cortisol level pathway link parent involv bedtim children nighttim sleep durat qualiti fifti one children male femal white biraci black famili particip parent involv presenc contact quiet activ assess rater video record one night bedtim children even cortisol level measur saliva sampl taken bedtim parent across three night children nighttim sleep minut effici determin actigraph worn three night path analys control child famili demograph provid support three signific indirect effect lower child even cortisol act pathway link greater parent presenc bedtim child nighttim sleep minut higher sleep effici lower child even cortisol also link greater parent contact bedtim higher sleep effici among low risk sampl find suggest encourag parent involv young children bedtim routin may promot healthi sleep way reduc child physiolog arous
|
D006854;D012890
|
T121;T109;T040;T033;T125
|
36,282,746
|
earli childhood stress respons psychosoci stressor state scienc aim systemat review better understand whether extent psychosoci stressor associ hypothalam pituitari adren axi autonom nervous system stress respons young children year age studi classifi psychosoci stressor ecobiodevelopment model social econom resourc matern mental health parent child relationship physic environ identifi studi met full inclus criteria includ children child physiolog stress respons measur hair urinari cortisol cortison salivari diurnal reactiv cortisol salivari reactiv alpha amylas respiratori sinus arrhythmia identifi relat psychosoci stressor physiolog stress respons near two third relat suggest children dysregul stress respons either signific blunt n increas n relat signific children consist signific dysregul stress respons experienc postnat matern depress anxieti reason mix find may relat characterist child ie moder stressor stress respons psychosoci stressor measur unmeasur variabl eg caregiv buffer research degre freedom public bias
|
D010913;D003348
|
T125;T022;T121;T109
|
36,282,745
|
associ matern emot regul child white matter connect black american mother child dyad parent emot regul play major role parent child interact turn neural plastic children particular sensit development period howev littl known parent emot dysregul associ variat children brain structur goal studi forti five black american mother child dyad recruit intergener trauma studi emot regul mother children age year assess diffus weight imag collect children determinist tractographi use reconstruct pathway relev emot regul metric white matter connect fraction anisotropi fa mean diffus md extract pathway socio econom variabl also includ statist model matern emot dysregul strongest predictor child fornix md r p indic sever emot dysregul mother correspond lower fornix connect children matern impuls strong predictor child fornix md r p matern emot dysregul may advers influenc connect child fornix hippocamp striatal pathway implic reward process associ remain even account socio environment factor dysregul matern emot may uniqu impact children adapt traumastress affect network support appetit process
|
D066127;D000080103
|
T041;T023;T024
|
36,282,744
|
signal nois dimens predict home auditori environ associ neurobehavior measur earli infant sustain attent home auditori environ influenc develop earli languag abil excess nois exposur increas link deficit languag read score children howev fewer studi consid role nois exposur shape develop attent process earli infanc foundat neurocognit skill relev learn use passiv home auditori record investig multipl dimens infant home auditori environ includ quantiti predict auditori input impact neural behavior measur sustain attent sociodemograph divers sampl month old infant n infant male age month sd hispaniclatino result indic infant expos predict pattern auditori input home demonstr longer overal time sustain attent laboratori assess addit infant experienc predict auditori input also demonstr greater relat increas electroencephalographi frontal theta power period sustain attent neural marker relev inform process attent control find provid novel evid import predict earli environment input shape develop cortic circuitri attent system first month postnat life
|
D001288;D004569
|
T060;T034;T041
|
36,282,743
|
emot express visual mismatch negat children detect chang facial emot crucial communic rapid process threat environ function develop throughout childhood via modul earliest brain respons p n record use electroencephalographi automat brain signatur measur express relat visual mismatch negat vmmn reflect process unattend chang increas research investig vmmn process adult studi conduct children control paradigm previous valid use disentangl specif respons emot deviant angri face neutral deviant latenc amplitud p n decreas age confirm sensori face specif activ yet matur school age children automat chang detect relat activ present children similar vmmn pattern respons emot neutral deviant stimuli previous observ adult howev vmmn process delay children compar adult emot specif respons yet observ suggest nonmatur automat detect salient emot cue knowledg first studi investig express relat vmmn school age children investig need confirm result
|
D004644;D004569
|
T060;T034;T041
|
36,282,741
|
autonom nervous system activ moder associ tempera extern behavior earli childhood temperament risk surgenc negat affect poor effort control posit predictor extern symptom develop howev autonom nervous system an activ under process reactiv regul may moder associ earli tempera later extern behavior earli childhood aim present studi examin interact rest sympathet sns parasympathet pns activ age may moder associ temperament risk age extern behavior age n result demonstr differ interact rest an activ temperament risk predict extern behavior children lower sns activ rest surgenc posit associ extern behavior negat affect posit associ extern behavior except either high level sns pns activ low level sns pns activ effort control associ extern behavior though sns pns activ interact predict extern behavior account effort control taken togeth result highlight import examin multisystem rest physiolog activ moder associ temperament risk develop extern behavior
|
D013694;D002653
|
T041;T048
|
36,282,740
|
infant temperament fear pupil dilat gaze avers smile stranger childhood higher level temperament fear earli emerg procliv distress face novelti associ lower social respons greater social anxieti earli emerg temperament fear infanc poor understood theoriz driven individu differ reactiv self regul novel stimuli current studi use eye track captur infant n reaction video smile stranger common social encount includ infant gaze avers stranger face index arous regul pupil dilat index physiolog reactiv longitudin month age multilevel mix effect model indic fear infant took time look away smile stranger face less fear infant suggest high fear infant may slower arous regul month fear infant also exhibit greater faster pupil dilat gaze avers consist greater physiolog reactiv togeth find suggest individu differ infant gaze avers pupil dilat index develop fear tempera earli infanc facilit identif intervent risk factor social disrupt
|
D012904;D011680
|
T023;T054
|
36,282,739
|
impact punish error relat brain activ children error relat negat ern sensit individu differ relat anxieti modul manipul increas threat valu commit error adult ern magnitud enhanc error follow punish especi among anxious individu punit parent relat elev ern children howev effect task base punish ern children yet understood furthermor need assess development period wherein ern might especi prone modul punish examin impact punish ern sampl children assess whether impact punish ern moder age anxieti punish potenti ern children especi among higher trait anxious individu punish potenti ern also associ older age interact child age anxieti symptom signific predict punish potenti ern howev child age anxieti symptom uniqu predict punish potenti ern anxious children may especi prone punish relat alter error monitor impact punish ern may becom pronounc children age
|
D011678;D004569
|
T078;T060;T034
|
36,282,738
|
influenc earli social isol general activ spatial learn adult wagrij rat studi identifi critic period earli ontogeni social factor greatest influenc oper behavior posit reinforc adult wagrij rat individu social isol rat dam sibl perform daili h postnat day pnd general activ water consumpt examin use intellicag ic adulthood oper behavior train perform four consecut session free explor ic environ adapt learn retriev water nosepok nosepok adapt spatial learn retriev water specif corner place learn retrain chang place prefer revers learn social isol pnd led greatest behavior chang session experi rat activ consum water demonstr higher ratio visit drink total number relearn faster chang locat reward corner thus postnat period day wagrij rat pup sensit social isol chang adapt behavior ic adulthood
|
D065853;D001522
|
T053;T041
|
36,282,737
|
mother sibl interact prewean period influenc myelin impuls propag sensori sural nerv adult rat investig whether mother sibl interact prewean period influenc histolog electrophysiolog characterist sensori sural nerv sun adult rat litter compos male pup p form pup routin weigh postnat day pnd pnd p p litter show greater bodi weight pup without sibl p p litter differ weight maintain adulthood analysi matern lick pnd show pup larg litter receiv fewer lick pup small size litter pnd sun rat p p litter greater compound action potenti cap amplitud higher proport axon larg myelin thick nerv rat p p p litter sun heaviest rat p p litter greater cap area myelin lightest rat litter propos complex interplay sensori social nutrit factor aris mother litterm interact prewean period influenc myelin propag action potenti sun adult rat
|
D013497;D035781
|
T023;T099
|
36,282,736
|
relationship low birth weight infant microbiom neurodevelop year age low birth weight vlbw infant g risk poor neurodevelopment outcom depend gestat age ga birth weight bw morbid earli life contribut gut microbiom well understood stool sampl collect week neonat intens care unit nicu vlbw infant week admiss year age battell develop inventori screen test bdi st administ year time point vlbw infant dysbiot microbiota nicu progress adult type microbiota year age bdi st result age year trigger referr test toddler year age seven continu requir referr nicu infant stool divers particular microbi amplicon sequenc variant associ bdi st subscal particular cognit adapt communic subscal control ga bw antibiot exposur network analysi nicu infant stool microbi ecolog show differ children need neurodevelopment referr result preliminari studi indic neonat gut microbiom play role earli cognit behavior neurodevelop
|
D019102;D064307
|
T184;T032;T028;T047;T001
|
36,282,731
|
answer comment articl sleep disord older peopl older peopl mexico citi sleep respons author articl sleep disord older peopl older peopl mexico citi sleep present carri pertin clarif
|
D012893;D007319
|
T184;T047;T048
|
36,282,726
|
comment articl sleep disord older peopl older peopl mexico citi sleep read articl publish revista mdica del imss mention preval cognit impair older adult reach known cognit test must adapt valid popul order avoid overestim cognit impair
|
D012893
|
T047;T048
|
36,282,719
|
modifi murin heterotop heart transplant protocol match contemporari standard asept techniqu anesthesia analgesia develop experiment model cardiac transplant anim contribut mani advanc field immunolog solid organ transplant heterotop vascular murin cardiac transplant model initi util studi graft reject use combin mismatch inbr mous strain access genet modifi strain therapeut modal provid power new preclin insight fundament surgic methodolog techniqu chang sinc develop especi respect import factor asept techniqu anesthesia analgesia make materi impact postsurg morbid mortal addit improv periop manag expect provid improv anim welfar experiment outcom paper report upon protocol develop collabor subject matter expert veterinari anesthesia describ surgic techniqu emphasi periop manag addit discuss implic refin provid detail troubleshoot critic surgic step procedur
|
D016027;D000758;D000698
|
T061
|
36,282,718
|
intravit microscopi studi platelet leukocyt endotheli interact mous liver inflamm thrombosi complex process occur primarili microcircul although standard histolog may provid insight end pathway inflamm thrombosi capabl show tempor chang occur throughout time cours process intravit microscopi ivm use live anim imag gain tempor insight physiolog process vivo method particular power assess cellular protein interact within circul due rapid sequenti event often necessari interact occur ivm extrem power imag methodolog capabl view complex process vivo number methodolog factor import consid plan ivm studi paper outlin process conduct intravit imag liver identifi import consider potenti pitfal may aris thus paper describ use ivm studi platelet leukocyt endotheli interact liver sinusoid studi relat contribut differ model acut liver injuri
|
D000069416;D007962
|
T060;T059;T025
|
36,282,717
|
live cell imag intact ex vivo globe use novel print holder corneal epitheli wound heal migratori process initi activ purinerg receptor express epitheli cell activ result calcium mobil event propag cell cell essenti initi cellular motil wound bed promot effici wound heal trinkaus randal lab develop methodolog imag corneal wound heal respons ex vivo murin globe real time approach involv enucl intact globe mous euthan per establish protocol immedi incub globe calcium indic dye counterstain stain featur cell appli stage assist imag show cellular landmark protocol work well sever differ live cell dye use counterstain includ sir actin stain actin deep red plasma membran stain stain cell membran examin respons wound corneal epithelium injur use g needl globe place print holder dimens print holder calibr ensur immobil globe throughout durat experi modifi accommod eye differ size live cell imag wound respons perform continu various depth throughout tissu time use confoc microscopi protocol allow us generat high resolut public qualiti imag use x air object confoc microscop object also use protocol repres signific improv qualiti live cell imag ex vivo murin globe permit identif nerv epithelium
|
D000199;D019573
|
T123;T116;T024
|
36,282,716
|
syngen mous orthotop allograft model pancreat cancer pancreat ductal adenocarcinoma pdac complex diseas character heterogen tumor microenviron made divers stroma immun cell vessel nerv extracellular matrix compon year differ mous model pdac develop address challeng pose progress metastat potenti phenotyp heterogen immunocompet mous orthotop allograft pdac shown good promis owe fast reproduc tumor progress comparison genet engin mous model moreov combin abil mimic biolog featur observ autochthon pdac cell line base orthotop allograft mous model enabl larg scale vivo experi thus model wide use preclin studi rapid genotyp phenotyp drug respons analys aim protocol provid reproduc robust approach success inject primari mous pdac cell cultur pancrea syngen recipi mice addit technic detail import inform given must consid perform experi
|
D010190;D021441
|
T191
|
36,282,715
|
vitro cleavag assay use purifi recombin drosophila caspas substrat screen caspas specif cell death proteas involv apoptot non apoptot process role caspas apoptosi well defin mani apoptot proteolyt substrat caspas identifi character role caspas non apoptot process well understood particular non apoptot substrat caspas identifi thus far order facilit identif character potenti caspas substrat protocol allow test candid substrat caspas cleavag assay vitro describ protocol includ product purif recombin caspas protein product candid substrat either recombin cell free express system actual vitro cleavag reaction follow sds page immunoblot protocol tailor drosophila caspas dronc drice easili adapt caspas organ includ mammal
|
D020169;D029721
|
T123;T126;T116
|
36,282,713
|
express transgen nativ bladder urothelium use adenovirus mediat transduct addit form high resist barrier urothelium line renal pelvi uret bladder proxim urethra hypothes sens transmit inform environ under tissu promot void function behavior disrupt urotheli barrier sensorytransduc function lead diseas studi complex event hamper lack simpl strategi alter gene protein express urothelium method describ allow investig generat larg amount high titer adenovirus use transduc rodent urothelium high effici relat straightforward manner cdnas small interf rnas express use adenovir transduct impact transgen express urotheli function assess h sever day later method broad applic studi normal abnorm urotheli biolog use mous rat anim model
|
D019459;D001743
|
T023;T024
|
36,282,712
|
micro displac measur base shadow techniqu precis measur micro displac import scientif industri field howev tough challeng due complex design high cost measur instrument inspir shadow form water strider walk water surfac sunlight micro displac measur method propos water strider leg superhydrophob properti bend water surfac curv surfac water refract sunlight creat shadow bright edg bottom pond shadow size general larger indent depth leg water surfac micro displac measur system appli displac proport chang diamet shadow present studi propos micro displac measur procedur base shadow techniqu displac sensit reach nmpixel rang system simpl construct low cost high precis good linear perform method provid conveni addit option measur micro displac
|
D014867
|
T121;T197
|
36,282,711
|
aptam base target detect facilit stage g quadruplex isotherm exponenti amplif reaction aptam target recognit molecul bind high affin specif characterist leverag control molecul signal generat capabl system describ herein target recognit aptamer domain stem ii modifi hammerhead ribozym activ self cleav ribozym stabil initi unstructur construct cis cleav rna act junction stem iii stem creat two cleavag product longer cleavag product prime isotherm exponenti amplif reaction expar two similar catalyt activ g quadruplex result amplif product catalyz peroxidas reduct coupl reduct colorimetr substrat output nake eye detect part system describ present studi improv detect modal enzym link immunosorb assay elisa produc visual detect signal indic presenc low theophyllin littl min
|
D054856;D021881;D016337;D015374;D052157
|
T116;T075;T059;T126;T114;T086
|
36,282,710
|
plastoglobul lipid droplet isol plant leaf tissu cyanobacteria plastoglobul lipid droplet dynam sub compart plant chloroplast cyanobacteria found ubiquit among photosynthet speci believ serv central role adapt remodel thylakoid membran rapid chang environment condit capac isol plastoglobul high puriti great facilit studi proteom lipidom methodolog plastoglobul high puriti yield possibl investig lipid protein composit enzymat activ protein topolog among possibl molecular characterist articl present rapid effect protocol isol plastoglobul chloroplast plant leaf tissu present methodolog variat isol plastoglobul relat lipid droplet structur maiz leav desicc leaf tissu resurrect plant eragrosti nindensi cyanobacterium synechocysti sp pcc isol reli low densiti lipid rich particl facilit purif sucros densiti flotat methodolog prove valuabl studi plastoglobul divers speci
|
D066292;D000458
|
T026;T007
|
36,282,709
|
complet method evalu perform photocatalyst degrad antibiot environment remedi various antibiot tetracyclin aureomycin amoxicillin levofloxacin found larg quantiti groundwat soil system potenti lead develop resist multi drug resist bacteria pose threat human anim environment system photocatalyt technolog attract keen interest due rapid stabl treatment direct use solar energi howev studi evalu perform semiconductor catalyst photocatalyt degrad organ pollut water current incomplet paper complet experiment protocol design comprehens evalu photocatalyt perform semiconductor catalyst herein rhombic dodecahedr silver phosphat prepar simpl solvent phase synthesi method room temperatur atmospher pressur brsubphthalocyanineagpo heterojunct materi prepar solvotherm method catalyt perform prepar materi degrad tetracyclin evalu studi differ influenc factor catalyst dosag temperatur ph anion atmospher pressur use w xenon lamp simul solar light sourc light intens mwcm compar first cycl construct brsubphthalocyanineagpo maintain origin photocatalyt activ five photocatalyt cycl pristin agpo maintain stabil silver phosphat sampl test five cycl experi paper provid complet process evalu catalyt perform semiconductor catalyst laboratori develop semiconductor catalyst potenti practic applic
|
D002751;D052918;D004785
|
T131;T195;T069;T109
|
36,282,708
|
estim yield compound tlc plate via blue led illumin techniqu thin layer chromatographi tlc access analyt techniqu extens use organ chemistri research quantifi yield unknown sampl present studi develop effect cheap safe method estim yield sampl tlc plate use blue led illumin lovastatin extract aspergillus terreus exampl compound use present studi regress model base lovastatin standard use evalu yield lovastatin three method compar bioassay uv detect blue led illumin result show blue led illumin method signific time effect uv detect bioassay method addit blue led illumin relat safe option concern biolog hazard bioassay method eg microbi infect ultraviolet exposur uv detect method compar expens method requir special instrument long term train work independ gc hplc hptlc use blue led illumin econom option estim yield sampl tlc plate
|
D008029;D008148
|
T068;T121;T109
|
36,282,707
|
singl cell analysi express pseudomona syringa gene within plant tissu plethora pathogen microorgan constant attack plant pseudomona syringa speci complex encompass gram negat plant pathogen bacteria special relev wide number host p syringa enter plant leaf surfac multipli rapid within apoplast form microcoloni occupi intercellular space constitut express fluoresc protein bacteria allow visual microcoloni monitor develop infect microscop level recent advanc singl cell analysi reveal larg complex reach clonal isogen bacteri popul complex refer phenotyp heterogen consequ cell cell differ gene express link genet differ among bacteri communiti analyz express individu loci singl cell level transcript fusion fluoresc protein wide use stress condit occur colon plant apoplast p syringa differenti distinct subpopul base heterogen express key virul gene ie hrp type iii secret system howev singl cell analysi given p syringa popul recov plant tissu challeng due cellular debri releas mechan disrupt intrins inocul bacteri extract process present report detail method develop monitor express p syringa gene interest singl cell level colon arabidopsi bean plant prepar plant bacteri suspens use inocul use vacuum chamber describ recoveri endophyt bacteria infect leav apoplast fluid extract also explain bacteri inocul bacteri extract method empir optim minim plant bacteri cell damag result bacteri prepar optim microscopi flow cytometri analysi
|
D044224;D000069296
|
T007;T116
|
36,282,706
|
scalabl cell base method function assess ubea variant increas use sequenc medicin identifi million code variant human genom mani variant occur gene associ neurodevelopment disord function signific vast major variant remain unknown present protocol describ studi variant ubea gene encod e ubiquitin ligas link autism angelman syndrom duplic triplic ubea strong link autism wherea delet caus angelman syndrom thus understand valenc chang ubea protein activ import clinic outcom rapid cell base method pair ubea variant wnt pathway report describ simpl assay scalabl use determin valenc magnitud activ chang ubea variant moreov facil method allow generat wealth structur function inform use gain deep insight enzymat mechan ubea
|
D017204;D001321
|
T047;T048
|
36,282,705
|
ring aortic band versus tradit transvers aortic constrict model pressur overload induc cardiac hypertrophi aortic band mice one common use experiment model cardiac pressur overload induc cardiac hypertrophi induct heart failur previous use techniqu base thread sutur around aortic arch tie blunt g needl creat stenosi method depend surgeon manual tighten thread thus lead high varianc diamet size newli refin method describ mellebi et al promis less varianc reproduc surgeri new techniqu ring aortic band orab use non slip rubber ring instead sutur thread result reduc variat pressur overload reproduc phenotyp cardiac hypertrophi surgeri ring place brachiocephal left carotid arteri success constrict confirm echocardiographi day correct placement ring result increas flow veloc transvers aorta ring induc stenosi week impair cardiac function proven decreas eject fraction increas wall thick import besid less varianc diamet size orab associ lower intra post oper mortal rate compar transvers aortic constrict tac thus orab repres superior method common use tac surgeri result reproduc result possibl reduct number anim need
|
D012408;D001024
|
T047;T122;T073;T109
|
36,282,704
|
sperm collect comput assist sperm analysi teleost model japanes medaka oryzia latip japanes medaka oryzia latip teleost fish emerg vertebr model ecotoxicolog development genet physiolog research medaka also use extens investig vertebr reproduct essenti biolog function allow speci perpetu sperm qualiti import indic male fertil thus reproduct success techniqu extract sperm sperm analysi well document mani speci includ teleost fish collect sperm relat simpl larger fish complic small model fish produc less sperm delic articl therefor describ two method sperm collect small model fish japanes medaka test dissect abdomin massag paper demonstr approach feasibl medaka show abdomin massag perform repeat number time fish quick recov procedur articl also describ protocol comput assist sperm analysi medaka object assess sever import indic medaka sperm qualiti motil progress durat motil relat concentr procedur specifi use small teleost model great enhanc understand environment physiolog genet factor influenc fertil vertebr male
|
D009990
|
T013
|
36,282,703
|
tripl primari cell cultur model human blood brain barrier studi ischem stroke vitro ischem stroke major caus death disabl worldwid limit therapeut option neuropatholog ischem stroke character interrupt blood suppli brain lead cell death cognit dysfunct ischem stroke blood brain barrier bbb dysfunct facilit injuri progress contribut poor patient recoveri current bbb model primarili includ endotheli monocultur doubl co cultur either astrocyt pericyt model lack abil fulli imit dynam brain microenviron essenti cell cell communic addit common use bbb model often contain immort human endotheli cell anim deriv rodent porcin bovin cell cultur pose translat limit paper describ novel well insert base bbb model contain primari human cell brain microvascular endotheli cell astrocyt brain vascular pericyt enabl investig ischem brain injuri vitro effect oxygen glucos depriv ogd barrier integr assess passiv permeabl transendotheli electr resist teer measur direct visual hypox cell present protocol offer distinct advantag inmimick intercellular environ bbb vivo serv realist vitro bbb model develop new therapeut strategi set ischem brain injuri
|
D000083242;D001930
|
T047;T037
|
36,282,702
|
partial sciatic nerv ligat mous model chronic neuropath pain studi antinocicept effect novel therapi manag chronic pain remain challeng day current treatment associ advers effect includ toler addict chronic neuropath pain result lesion diseas somatosensori system investig potenti therapi reduc side effect anim pain model gold standard preclin studi therefor well character well describ model crucial develop valid innov therapi partial ligat sciatic nerv psnl procedur induc chronic neuropath pain mice character mechan thermal hypersensit ongo pain chang limb temperatur make model great fit studi neuropath pain preclin psnl advantag model studi neuropath pain reproduc mani symptom observ human neuropath pain furthermor surgic procedur relat fast straightforward perform unilater psnl one limb allow comparison ipsilater contralater paw well evalu central sensit induc chronic neuropath hypersensit non absorb nylon thread use ligat dorsal third sciatic nerv articl describ surgic procedur character develop chronic neuropath pain multipl common use behavior test plethora innov therapi investig treat chronic pain articl provid crucial concept standard accur descript surgeri requir induc neuropath pain
|
D059350;D009437
|
T184;T047
|
36,282,700
|
polytetrafluoroethylen ptfe sutur materi tendon surgeri evolut sutur materi chang paradigm primari secondari tendon repair improv mechan properti allow aggress rehabilit earlier recoveri howev repair hold higher mechan demand advanc sutur knot techniqu must assess combin materi protocol use polytetrafluoroethylen ptfe sutur materi combin differ repair techniqu investig first part protocol linear tension strength elong knot knot strand three differ materi use flexor tendon repair evalu three differ materi polypropylen ppl ultra high molecular weight polyethylen braid jacket polyest uhmwp polytetrafluoroethylen ptfe next part ex vivo experi cadaver flexor tendon behavior ptfe use differ sutur techniqu assess compar ppl uhmwp experi compris four step harvest flexor tendon fresh cadaver hand transect tendon standard manner tendon repair four differ techniqu mount measur tendon repair standard linear dynamomet uhmwp ptfe show compar mechan properti signific superior ppl term linear traction strength repair four six strand techniqu prove stronger two strand techniqu handl knot ptfe challeng due low surfac friction fasten four six strand repair compar easi achiev surgeon routin use ptfe sutur materi cardiovascular surgeri breast surgeri ptfe strand suitabl use tendon surgeri provid robust tendon repair earli activ motion regimen rehabilit appli
|
D011138;D013708
|
T122;T037;T109
|
36,282,699
|
dendrochronolog date provenanc string instrument dendrochronolog scienc date tree ring wood defin calendar year particular tree ring form method use determin age authent wooden music instrument present protocol describ perform dendrochronolog analysi string instrument interpret date protocol describ basic step analysi top plate usual made norway spruce picea abi rare silver fir abi alba first top plate care inspect tree ring width measur direct instrument use high resolut imag complet measur tree ring sequenc instrument creat next step date perform number refer chronolog tree speci differ geograph area instrument specialist date instrument also invest work creat refer chronolog dendrochronolog report provid date instrument calendar year end date indic year last recent tree ring top plate form tree still aliv end date repres terminus post quem year instrument made could made estim year manufactur one must consid time requir wood dri store number tree ring remov wood process protocol intend help commiss analysi better understand analysi perform interpret dendrochronolog report term age origin maker authent instrument
|
D028202;D028222
|
T002
|
36,282,698
|
imag age cochlea light sheet fluoresc microscopi deaf common sensori impair affect approxim million peopl worldwid per world health organ age presbycusi primari caus sensorineur hear loss character damag hair cell spiral ganglion neuron sgns stria vasculari structur resid within cochlea complex spiral shape anatomi membran tissu suspend fluid surround bone properti make technic difficult investig quantifi histopatholog chang address need develop light sheet microscop tslim imag digit whole cochlea facilit studi structur function relationship inner ear well align serial section whole cochlea result stack imag three dimension volum render segment individu structur visual quantit analysi ie length width surfac volum number cochlea requir minim process step fixat decalcif dehydr stain optic clear compat subsequ high resolut imag scan transmiss electron microscopi sinc tissu present stack structur assess individu relat structur addit sinc imag use fluoresc probe immunohistochemistri ligand bind use identifi specif structur volum distribut within cochlea use tslim examin cochlea age mice quantifi loss hair cell spiral ganglion neuron addit advanc analys eg cluster analysi use visual local reduct spiral ganglion neuron rosenth canal along volum approach demonstr tslim microscopi abil quantifi structur function relationship within cochlea
|
D005456;D003051
|
T023;T130
|
36,282,697
|
oral combin antiretrovir treatment hiv infect human mice human immunodefici virus hiv pandem continu spread unab worldwid current vaccin avail hiv although combin antiretrovir therapi cart success suppress viral replic complet erad reservoir hiv infect individu safe effect cure strategi hiv infect requir multiprong method therefor advanc anim model hiv infect pivot develop hiv cure research human mice recapitul key featur hiv infect human mous model infect hiv viral replic control cart regimen moreov cart interrupt result prompt viral rebound human mice howev administr cart anim ineffect difficult toxic mani clinic relev cart regimen unabl optim util along potenti unsaf research administr cart common use intens daili inject procedur induc stress physic restraint anim novel oral cart method treat hiv infect human mice describ articl result suppress viremia detect level increas rate cd restor improv overal health hiv infect human mice
|
D015658;D015497
|
T047;T005
|
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