PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,282,341
|
effect valent pneumococc polysaccharid vaccin invas pneumococc diseas among individu year age danish cohort studi studi aim estim effect valent pneumococc polysaccharid vaccin ppv invas pneumococc diseas ipd among individu year age use danish nationwid databas obtain inform ppv vaccin covari ipd link data individu level use uniqu person identifi total individu includ follow june septemb vaccin follow adjust vaccin effect confid interv ci serotyp ipd ci ppv serotyp ipd use vaccin refer
|
D022242;D011008
|
T129;T047;T121
|
36,282,340
|
develop valid effici nomogram risk assess norovirus infect pediatr patient studi aim establish predict model nomogram base routin laboratori blood indic clinic symptom subsequ provid rapid risk assess norovirus nov infect children retrospect studi enrol pediatr patient symptom acut gastroenter detect nov use real time quantit polymeras chain reaction signific indic select multivari logist regress includ routin blood test consult symptom use develop nomogram divid sampl train intern valid set perform extern valid final model furthermor evalu clinic perform use akaik inform criterion aic area curv auc calibr curv decis curv analysi dca sensit specif concord rate posit predict valu negat predict valu overal case nov pcr posit negat multivari logist regress includ five predictor nov infect includ symptom vomit upper respiratori tract infect indic white blood cell lymphocyt absolut count platelet count nomogram show signific predict valu overal intern set diagnosi auc confid interv ci ci ci train intern valid set respect nevertheless auc extern valid set higher ci nomogram use tool risk assess nov infect moreov evalu indic access substanti reduc time laboratori test
|
D049451;D017250
|
T081;T047;T170
|
36,282,338
|
impact preanalyt freez delay time stabil metabolit oral squamous cell carcinoma tissu sampl metabolit stabil critic tissu metabolom howev chang metabolit tissu time oper room laboratori remain underexplor
|
D009062;D002294;D006258
|
T191
|
36,282,316
|
vitro forestomach digest experi give less bias estim food composit odontocet diet composit odontocet usual infer stomach content analys account digest rate deriv vitro digest experi base seal physiolog howev pinnip carnivor one stomach compart odontocet cetartiodactyla four inappropri extrapol digest process simul seal stomach may result bias estim odontocet diet simul forestomach account muscl contract ph use vitro experi three fish speci white merlangius merlangus black gobi gobius niger sprat sprattus sprattus show high variabl exponenti sigmoid linear digest function high digest rate take min complet digest previous pinnip model ph lack simul muscular digest show much slower similar digest process result suggest present biomass intak estim odontocet bias toward bigger fattier fish need revis general
|
D005399;D048388
|
T168;T013
|
36,282,296
|
glatiram acet complex cpg intratumor immunotherapi combin anti pd cpg oligodeoxynucleotid toll like receptor agonist capabl induc potent pro inflammatori immun respons although cpg oligodeoxynucleotid shown promis antitumor effect system activ trigger immun relat toxic limit therapeut applic previous identifi glatiram acet ga cation polypeptid approv treatment relaps remit multipl sclerosi intratumor deliveri agent capabl complex cpg therebi pin inject site limit system exposur investig whether combin cpg ga cpg polyplex intraperiton anti pd therapi would result synergist efficaci ct murin syngen model head neck colon cancer respect ct tumor model intratumor cpg ga cpg treatment similar suppress tumor growth efficaci amplifi anti pd nevertheless combin treatment increas cytotox cell helper cell natur killer cell infiltr tumor surpris combin intratumor ga intraperiton anti pd treatment result elev system gm csf il cytokin level demonstr synergist antitumor effect ct mous tumor model moreov tumor respond signific anti pd plus ga treatment show increas marker infiltr cd cell natur killer cell combin intratumor ga ga cpg polyplex anti pd treatment warrant investig combin cancer immunotherapi strategi
|
D007167;D009369
|
T061;T191
|
36,282,289
|
well develop coronari collater circul associ higher thrombus burden set st segment elev myocardi infarct studi investig relationship coronari collater circul ccc intracoronari thrombus burden patient undergo primari percutan coronari intervent st segment elev myocardi infarct stemi ccc thrombus burden predict clinic outcom patient stemi
|
D000072657;D003328;D062645;D009203
|
T061;T047
|
36,282,281
|
meralgia paraesthetica complic patient posit fulli control risk meralgia paraesthetica mp consequ entrap stretch injuri later femor cutan nerv cross region inguin ligament nerv exit pelvi result temporari perman sensori loss paraesthesia pain anterolater region thigh idiopath form known exampl seat belt syndrom jean syndrom mp also occur complic surgic intens care patient posit focus lithotomi posit prone posit beach chair positionw analyz complaint mp occur first time postop submit expert committe medic treatment error north rhine medic associ past year among six case could identifi posit damag lithotomi posit three case mp occur supin posit etiolog could clarifi certainti case mp recogn direct surgic complicationth pathophysiolog incid cours well legal implic posit relat mp discuss pressur damag nerv intersect inguin ligament assum main pathomechan although case present occur lithotomi posit complic also appear occur type posit accord literatur data common prone posit also explain increas publish case report mp prone posit covid patient respiratori treatment safe avoid posit relat complic appear possibl due anatom variabl cours nerv unclear pathomechan
|
D020428;D009408;D000086382
|
T047;T067
|
36,282,256
|
associ hospit particip bundl payment care improv advanc medicar spend hospit incent payment bundl payment care improv advanc bpci center medicar medicaid servic cms initi aim produc financi save incentiv decreas clinic spend incent consist financi bonus cms hospit penalti paid hospit cms
|
D006278;D009042;D064872;D017721;D058996
|
T078;T061;T080;T081;T089;T064;T041;T057
|
36,282,254
|
major develop medic school narrat medicin essay second year medic student discuss manag major depress disord navig medic school baffl mental ill littl discuss medic curricula beyond
|
D012577
|
T073;T093
|
36,282,253
|
hypercalcemia review hypercalcemia affect approxim worldwid popul mild hypercalcemia defin total calcium less mgdl mmoll ioniz calcium mgdl greater mmoll develop rapid day week caus nausea vomit dehydr confus somnol coma
|
D006934;D049950;D010281
|
T123;T121;T116;T125;T047
|
36,282,249
|
fit kinet scan electrochem microscopi imag finit circular featur scan electrochem microscopi secm power techniqu imag electrochem reactiv surfac unfortun secm imag main use qualit kinet reaction surfac almost exclus obtain microelectrod current approach surfac call approach curv approach curv method excel reaction surfac kinet everywher design fit kinet finit size reactiv featur propos method extract kinet featur area microelectrod tip substrat distanc secm imag fit simul imag reactiv disc use levenberg marquardt algorithm area experiment reactiv featur fit within under featur rough disc shape reaction simul reactiv featur activ limit rate constant fit within true valu work herald begin quantifi kinet secm imag
|
D064347
|
T059
|
36,282,248
|
mtorc beyond anabol metabol regul cell death mechanist target rapamycin complex mtorc multi subunit protein kinas complex interrog growth factor signal cellular nutrient energi status control metabol homeostasi activ mtorc promot biosynthesi macromolecul includ protein lipid nucleic acid simultan suppress catabol process lysosom degrad self constitu extracellular compon metabol regul emerg critic determin various cellular death program includ apoptosi pyroptosi ferroptosi articl review expand knowledg mtorc coordin metabol pathway imping cell death regul focus current understand nutrient status cellular signal pathway connect mtorc activ ferroptosi iron depend cell death program implic plethora human diseas depth understand principl govern interact mtorc cell death pathway ultim guid develop novel therapi treatment relev patholog condit
|
D017209;D000076222;D000069292;D000079403
|
T123;T116;T043
|
36,282,247
|
mitoguardin mediat lipid transfer preserv mitochondri morpholog lipid droplet format lipid transport protein membran contact organell close appos critic redistribut lipid endoplasm reticulum er made cellular membran protein mediat transfer especi import maintain organell disconnect secretori pathway like mitochondria identifi mitoguardin mitochondri protein contact er andor lipid droplet lds lipid transport x ray structur show c termin domain mitoguardin hydrophob caviti bind lipid mass spectrometri analysi reveal glycerophospholipid free fatti acid co purifi mitoguardin cell mitoguardin accommod two lipid mitoguardin transfer glycerophospholipid membran vitro transport abil requir role mitochondri ld biolog establish protein mediat transfer contact play role ld metabol find rais possibl mitoguardin function transport fatti acid glycerophospholipid mitochondria ld contact
|
D066292;D050356;D008928;D024101
|
T026;T123;T116;T043;T044
|
36,282,241
|
nicot famili metal transport mycobacterium tuberculosi rvnict behav drug efflux pump facilit cross resist antibiot metal often act facilit prolifer persist antibiot resist efflux pump play key role co select metal antibiot resist report abil putat nickelcobalt transport nicot famili rv nict mycobacterium tuberculosi mtb transport metal antibiot identifi key amino acid residu import function ectop express nict escherichia coli cs result increas intracellular nickel uptak addit enhanc toler toward sever antibiot norfloxacin sparfloxacin ofloxacin gentamicin nalidix acid isoniazid observ nict overexpress e coli mycobacterium smegmati compar lower intracellular accumul norfloxacin upon nict overexpress cell without nict indic involv nict activ efflux process although express nict alter sensit toward kanamycin doxycyclin tetracyclin apramycin neomycin ethambutol presenc sub inhibitori dose ni result manifest low level toler toward drug substitut four residu hi di hl di conserv region nict isoleucin leucin result reduc near complet loss transport function metal antimicrobi therefor studi suggest nickel transport rvnict may activ export differ drug presenc nickel might drive cross resist antibiot
|
D009169
|
T007
|
36,282,236
|
general label free fluoresc aptam bind assay use cation conjug polym new aptam report general cost effect yet reliabl aptam bind assay still need herein studi cation conjug polym ccp base bind assay take advantag conform chang aptam bind target reflect fluoresc chang ccp poli n n n triethylamino propyloxi methyl thiophen hydrochlorid pmnt use model ccp studi optim buffer close physiolog condit mm nacl mm mgcl character four aptam k adenosin cortisol caffein cortisol caffein drop nm peak intens use quantif wherea k adenosin fluoresc ratio nm use longer stem stem loop structur aptam facilit bind target enlarg detect signal high specif achiev differenti target analogu compar sybr green dye base stain method method achiev equal even higher sensit therefor assay practic general aptam bind assay simpl label free quick respons cost effect featur make use method evalu aptam bind time system also serv label free biosensor target detect
|
D052157;D015374
|
T075;T059;T114
|
36,282,216
|
real time imag rna polymeras activ live human cell rna polymeras pol synthes cellular rna transcrib multipl copi ribosom rna gene rdna transcript activ pol control level ribosom biogenesi cell growth howev current lack method monitor pol activ real time develop liveart live imag base analysi rdna transcript visual quantifi spatiotempor dynam endogen ribosom rna rrna synthesi liveart reveal mitot silenc reactiv rdna transcript well transcript kinet interphas rdna use liveart identifi srfbp potenti regul rrna synthesi show rdna transcript occur burst alter modul burst durat amplitud import liveart high effect screen applic anticanc drug target pol transcript approach pave way deeper understand mechan under nucleolar function
|
D012318;D014158
|
T045;T126;T116
|
36,282,215
|
rufi bind arlb mediat endosom tgn ci mpr retriev cargo sort lysosom arlb arf like gtp bind protein regul cargo traffick posit lysosom howev unknown whether arlb regul lysosom cargo sort report arlb bind rab rab interact partner run fyve domain contain protein rufi known regul cargo sort recycl endosom arlb determin rufi endosom local regul interact rab rufi deplet led delay ci mpr retriev endosom tgn result impair deliveri newli synthes hydrolas lysosom identifi dynein dynactin complex rufi interact partner similar subset activ dynein adaptor coil coil region rufi requir interact dynein abil mediat dynein depend organell cluster find suggest arlb rufi play novel role recycl endosom machineri regul endosom tgn retriev ci mpr consequ lysosom cargo sort
|
D020727;D004398;D011992;D008247;D020691;D048868
|
T026;T123;T126;T116
|
36,282,214
|
hemicentin mediat type iv collagen assembl strengthen juxtapos basement membran linkag basement membran bm matric surround separ tissu howev poor understood mechan bms adjac tissu also stabli link support organ structur function use endogen knock fluoresc protein condit rnai optogenet quantit live imag identifi extracellular matrix protein mediat bm linkag b link uterin uts epiderm seam cell bms caenorhabd elegan support uterus egg lay found hemicentin secret uts promot fibulin assembl joint initi b link egg lay howev protein level declin requir b link mainten instead discov hemicentin recruit adamt facilit assembl high level type iv collagen sustain b link mechan activ egg lay period work reveal mechan under bm bm linkag matur identifi crucial function hemicentin fibulin initi attach type iv collagen strengthen special form tissu linkag
|
D001485;D017173;D029742;D024141
|
T123;T204;T116;T024
|
36,282,210
|
hydrogen bond donor drug design hydrogen bond donor seen caus problem drug design hydrogen bond acceptor polar drug like compound come hydrogen bond acceptor sinc typic exceed hydrogen bond donor number heavili solvat individu basi implic polar imbal optim permeabl aqueous solubl discuss factor consid optim ligand recognit target presenc hydrogen bond donor general impli hydrogen bond acceptor also present vice versa frustrat solvat secondari electrostat interact result align hydrogen bond donor acceptor design opportun present phenomena discuss hydrogen bond donor base oxygen nitrogen carbon compar target recognit element halogen chalcogen bond donor discuss hydrogen bond donor equival
|
D006219;D006859
|
T196
|
36,282,208
|
review articl clinic assess suspect drug induc liver injuri manag idisyncrat drug induc liver injuri dili rare instanc liver injuri exposur otherwis safe drug herbal dietari supplement dili associ signific morbid mortal furthermor import consider drug develop due safeti concern
|
D056486
|
T047;T037
|
36,282,206
|
particip signal protein sperm hyperactiv sperm hyperactiv describ fast whip movement flagellum irregular trajectori asymmetr flagellum bend motil pattern achiev passag sperm along femal genit tract help spermatozoa cross differ viscous ambient fluid final reach oocyt import signal protein locat sperm head flagellum play import role cascad control sperm hyperactiv presenc hco modul activ solubl adenylyl cyclas sac lead product camp turn camp modul sperm specif na h exchang snhe complex protein tcp play essenti role signal pathway camppka tyrosin phosphoryl sperm hypermotil snhe cystic fibrosi transmembran conduct regul cftr voltag gate proton channel hv main contribut regul intracellular ph phi capacit hco entranc remov h cytoplasm induc alkal phi chang contribut activ cation channel sperm catsper recent describ particip sperm motil regul calcium channel autophagi relat protein microtubul associ protein light chain lc review gather import literatur essenti role sac snhe cftr hv catsper acquisit sperm hyperactiv provid integr overview recent describ role tcp lc sperm signal pathway addit provid insight infertil induc dysfunct critic protein
|
D013081;D019005
|
T123;T116;T043
|
36,282,201
|
standard transfemor transcathet aortic valv replac introduct transcathet aortic valv implant procedur revolution standard care patient aortic valv patholog signific increas qualiti medic treatment provid durabl constant technic improv modern transcathet aortic valv implant procedur broaden indic toward younger patient group low risk profil therefor transcathet aortic valv implant repres effect altern surgic aortic valv replac larg number case current various technic method transcathet aortic valv implant procedur avail contemporari transcathet aortic valv implant procedur focus optim postop result reduct complic paravalvular leakag perman pacemak implant anoth goal transcathet aortic valv implant achiev valid lifetim concept secur coronari access condit futur valv valv intervent case report demonstr standard transfemor transcathet aortic valv implant procedur self expand supra annular devic one common perform method
|
D065467;D001024;D006350
|
T061;T047;T074
|
36,282,195
|
protect effect breastfeed ingest human breast milk subsequ risk endometriosi mother child systemat review meta analysi background endometriosi chronic debilit diseas character ectop endometrium like tissu outsid uterin caviti object current meta analysi conduct evalu effect breastfeed ingest human breast milk subsequ risk endometriosi materi method english persian databas systemat search accord mesh browser keyword free text word march newcastl ottawa use evalu qualiti includ studi public bias assess use begg egger test funnel plot heterogen studi evalu use statist result random effect meta analysi present use odd ratio or confid interv cis result total articl subject includ meta analysi overal pool estim show breastfeed ci ingest human breast milk ci signific protect effect risk endometriosi conclus find confirm invers associ endometriosi risk ingest human breast milk breastfeed therefor import breastfeed mother child consid policymak health care provid
|
D004715
|
T047;T191
|
36,282,193
|
intervent improv breastfeed outcom late preterm earli term infant background late preterm infant lpis born gestat week earli term infant eti gestat week higher risk morbid mortal compar matur infant breastfeed reduc risk feed difficulti common among infant breastfeed rate low conduct systemat review identifi intervent avail improv breastfeed exclus breastfeed breast milk yield method literatur search perform februari use medlin cinahl embas googl scholar nine articl includ one articl random control trial one includ eti remain articl quasi experiment includ lpis outcom includ breastfeed durat breastfeed exclus andor breast milk product volum month actual age result profession support signific improv exclus breastfeed rate breastfeed educ program deliv hospit week telephon follow postdischarg signific increas breastfeed rate neither cup feed earli discharg home lactat support improv breastfeed rate wherea room versus direct admiss neonat intens care unit worsen exclus breastfeed rate discuss first systemat review identifi intervent avail lpis eti overal limit studi investig intervent promot breastfeed popul howev breastfeed support deliv health care profession seem improv breastfeed rate main limit lack random blind adjust confound variabl experiment studi robust methodolog design need
|
D001942;D007234
|
T055;T040;T033;T100;T058
|
36,282,190
|
breastfeed durat invers associ postpartum allostat load possibl mechan improv matern health background allostat load multisystem composit measur chronic stress reflect cumul wear tear bodi util explain matern child health dispar predict futur health measur peripartum period research use cross section data demonstr invers associ concurr breastfeed status matern postpartum allostat load howev relationship breastfeed durat postpartum allostat load determin object studi aim examin associ breastfeed durat postpartum allostat load use prospect data compar associ raceethn better understand etiolog health inequ materi method secondari analysi data sampl postpartum women communiti child health research network conduct multipl linear regress test associ breastfeed durat allostat load rang calcul biomark month postpartum adjust raceethn matern age educ poverti level studi center smoke marit status prepregn bodi mass index stratifi analys examin differ associ raceethn result breastfeed durat invers associ matern allostat load adjust model mother breastf month point lower allostat load month ci point lower allostat load month postpartum ci compar mother never breastf effect size vari strength signific across raceethn group conclus studi find suggest extend breastfeed least month link reduc chronic stress load mother first year postpartum inconsist find across raceethn group signal import adjust prepregn allostat load futur studi
|
D001942;D052636
|
T055;T040;T081;T039;T058
|
36,282,180
|
effect desicc freez microbi ioniz radiat surviv consider mar sampl return increas nation space agenc expand goal includ mar explor sampl return better protect earth biospher potenti extraterrestri sourc contamin set forth outer space treati intern effort develop planetari protect measur strive understand danger cross contamin process mar sampl return mission aim better understand impact martian surfac microbi dormanc surviv radiat resist microb key paramet consid surviv microb geolog time frigid arid surfac mar bombard solar galact cosmic radiat test influenc desicc freez ioniz radiat surviv six model microorgan veget cell two bacteria deinococcus radioduran escherichia coli strain bud yeast saccharomyc cerevisia veget cell endospor three bacillus bacteria b subtili b megaterium b thuringiensi desicc freez great increas radiat surviv veget polyploid microorgan appli separ combin desicc freez increas radiat surviv even thus radiat surviv threshold polyploid radioduran cell extend alreadi high valu kgi liquid cultur astonish kgi cell desicc frozen howev synergist radioprotect effect desicc freez observ monogenom digenom bacillus cell endospor general steril kgi differ associ critic requir surviv radiat repair genom damag caus radiat deinococcus radioduran cerevisia accumul similar high level mn antioxid requir extrem radiat resist endospor though great exceed spore radioresist contain multipl ident genom copi radioduran join persist holliday junction estim ioniz radiat surviv limit polyploid dna base life form hundr million year background radiat buri martian subsurfac find impli forward contamin mar essenti perman backward contamin possibl life ever exist mar
|
D005118;D018535
|
T083;T070
|
36,282,174
|
comprehens machin learn surviv framework develop consensus model larg scale multicent cohort pancreat cancer aggress tumor outcom pancreat cancer paca improv observ last decad anatomi base tnm stage exact identifi treatment sensit patient ideal biomark urgent need precis medicin base express file patient multicent cohort screen consensus prognost gene ten machin learn algorithm transform combin select optim algorithm construct artifici intellig deriv prognost signatur aidp accord averag c index nine test cohort result train cohort nine test cohort meta cohort three extern valid cohort patient consist indic aidp could accur predict prognosi paca incorpor sever vital clinicopatholog featur publish signatur aidp exhibit robust dramat superior predict capabl moreov preval digest system tumor nine gene aidp could still accur stratifi prognosi note aidp import clinic implic paca patient low aidp own dismal prognosi higher genom alter denser immun cell infiltr well sensit immunotherapi meanwhil high aidp group possess observ prolong surviv panobinostat may potenti agent patient high aidp overal studi provid attract tool guid clinic manag individu treatment paca
|
D020869;D010190
|
T063;T191;T059
|
36,282,173
|
molecular dynam investig giant cluster small molecul solut case aqueous peha import format giant cluster solut natur industri increas recogn howev relat littl attent paid format giant cluster solut small relat solubl nonamphiphil molecul work present general methodolog base molecular dynam use investig system case studi focus format appar stabl cluster pentaethylenehexamin peha water cluster use templat construct bioinspir silica nanoparticl better understand cluster system studi effect peha proton state neutral counterion type chlorid acet peha cluster dilut aqueous solut mm use larg scale classic molecular dynam find larg stabl cluster form singl charg peha chlorid acet counterion although clear case acet whether bulk phase separ might lead precipit would eventu occur larg cluster also appear stabl doubli charg peha acet less solubl counterion attribut behavior form complex coacerv observ relat small high solubl molecul peha counterion rather larg polyion usual found form coacerv discuss whether behavior might also describ effect salr short rang attract long rang repuls interact work might help futur studi addit design novel bioinspir templat nanomateri giant cluster small molecul solut general
|
D056004;D002712
|
T066;T196;T044;T034
|
36,282,171
|
life line larg virus long suspect poxvirus captur host gene revers transcript process shown mediat retrotransposon
|
D018626;D011212
|
T123;T005;T114
|
36,282,170
|
singl dose tranexam acid infus safe effect reduc total blood loss proxim femor nail intertrochanter fractur prospect random studi tranexam acid txa shown reduc intraop bleed need post oper allogen blood transfus requir surgeri random control studi aim evalu effect pre oper mgkg intraven txa total blood loss tbl hidden blood loss hbl transfus requir elder patient group intertrochanter femor fractur itff treat proxim femor nail pfn
|
D014148;D000933;D005594;D006620
|
T061;T121;T037;T109
|
36,282,169
|
earli post oper morbid mortal predictor peptic ulcer perfor peptic ulcer perfor pup one caus acut abdomen incid entiti abdomin emerg numer prognost factor report morbid mortal pup studi attempt analyz factor affect mortal morbid patient pup
|
D010439;D004381;D051437
|
T047
|
36,282,168
|
magnesium dexmedetomidin combin reduc sodium nitroprussid requir laparoscop pheochromocytoma anesthesia manag pheochromocytoma excis surgeri associ sever hemodynam fluctuat object studi compar number hypertens crisi requir sodium nitroprussid snp administr group treat magnesium mg dexmedetomidin dex convent group pheochromocytoma
|
D010673;D020927;D000310;D010535
|
T061;T121;T109;T060;T191
|
36,282,167
|
erectil dysfunct patient major burn injuri signific follow prospect studi investig relationship burn injuri erectil dysfunct ed aim studi prospect explor alter erectil function regard major burn
|
D007172;D002056
|
T047;T037
|
36,282,166
|
investig correl sever acut pancreat pancreat necrosi serum paramet acut pancreat ap diseas relat signific morbid even mortal various factor involv etiolog especi gallston excess alcohol consumpt although cours diseas case general mild case diseas sever lead pancreat peripancreat necrosi radiolog balthazar comput tomographi sever index ctsi use assess sever presenc necrosi pancreat studi classifi sever ap patient balthazar ctsi investig whether correl serum paramet ap sever serum paramet use safe marker predict ap sever develop pancreat necrosi pn
|
D019283
|
T047
|
36,282,165
|
relationship admiss neutrophillymphocyt thrombocytelymphocyt monocytelymphocyt ratio year mortal geriatr hip fractur tripl comparison elder patient hip fractur high post oper year mortal rate aim studi investig relationship neutrophillymphocyt ratio nlr thrombocytelymphocyt ratio tlr monocytelymphocyt ratio mlr mortal
|
D009504;D006620
|
T025;T037
|
36,282,164
|
tubal ectop pregnanc acut abdomin present case control analysi aim studi evalu demograph data clinic find ectop pregnanc ep local left right side treatment versus clinic present tubal pregnanc tp without acut abdomen
|
D011274;D011271;D000006
|
T184;T046
|
36,282,163
|
manag hepat arteri trauma hepato pancreato biliari procedur evolv approach clinic outcom literatur review one fear complic surgeon deal hepato pancreato biliari hpb surgeri hepat arteri ha injuri aim evalu clinic experi lacer transect ligat resect relat ha trauma serious morbid mortal risk light literatur data rapid evolv manag method recent year
|
D006499;D001659
|
T023
|
36,282,162
|
burn germ cell tumor present acut abdomen acut abdomen serious condit frequent encount emerg depart ed various etiolog caus acut abdomen common acut append howev rare caus acut abdomen well one keep mind handl patient unusu clinic featur herein present year old male past medic surgic histori present acut abdomin pain distens ed found larg vascular retroperiton mass comput tomographi invad perfor duodenum thus caus acut present repair duoden perfor sampl mass perform term surgic manag patholog result reveal mass origin burn testi yolk sac tumor embryon carcinoma compon although origin tumor regress testi metastasi retroperiton area caus clinic condit entiti describ retroperiton metastasi burn testicular tumor case present gastrointestin bleed secondari invas retroperiton metastasi report howev first case literatur present duoden perfor acut abdomen sampl retroperiton tumor histopatholog diagnosi immedi surgic intervent facilit diagnost manag case although scrotal examin combin testi tumor marker assess essenti optim patient manag possibl burn testicular tumor normal scrotal examin alway kept mind
|
D012186;D000006;D009373;D013736
|
T184;T191
|
36,282,161
|
preval household meat grinder induc sever hand injuri retrospect clinic studi aim studi evalu patient household meat grinder relat hand injuri present hospit investig caus injuri discuss prevent method
|
D005383;D006230;D000673
|
T037
|
36,282,160
|
comparison analges consumpt hemophil non hemophil patient knee arthroplasti hemophilia rare hereditari bleed disord develop result factor viii ix defici long term complic hemophilia arthropathi synov arthriti lead develop recurr chronic pain pain therefor critic aspect hemophilia gold standard treatment end stage hemophil knee arthropathi total knee arthroplasti tka hypothesi studi knee replac surgeri caus sever post oper pain hemophilia patient chronic analges consumpt may experi higher level pain non hemophil patient use opioid non opioid drug
|
D019645;D006467;D014147;D007592
|
T061;T121;T047;T109
|
36,282,159
|
effect glutamin use format intestin neomucosa periton surfac rat short bowel syndrom sbs clinic condit high mortal morbid lead lack absorpt fluid nutrient necessari bodi due decreas length small bowel sb glutamin amino acid essenti nutrit prolifer intestin mucosa cell main aim present studi investig effect glutamin intestin neomucosa format rat develop sbs
|
D005973;D000975
|
T123;T121;T116;T039;T044
|
36,282,158
|
safe harvest proxim fractur fibula osseocutan anterograd pedicl flap proxim tibial reconstruct subacut period case report literatur review osteoseptocutan fibula flap common use workhors flap bone reconstruct howev use previous fractur fibula free pedicl flap bone reconstruct limit knowledg literatur data literatur case proxim level fibula fractur use anterograd pedicl osteocutan fibula flap composit tibial reconstruct high energi injuri base patient composit defect proxim tibial region reconstruct osteocutan fibula flap gunshot injuri tri show fibula proxim level fractur could use anterograd flow subacut period thought usabl flap kept mind possibl harvest pedicl fibula flap even subacut period evalu ct angiographi preoper check patenc flow direct peron arteri periop success procedur may increas total dissect inflammatori area pedicl would extend injuri zone subacut period
|
D007869;D019651;D058752
|
T061;T024;T037
|
36,282,157
|
air gun injuri pericardium year old boy author present case year old boy sustain gunshot injuri pericardium air gun penetr wound pericardium accord perform pre oper diagnost method initi believ penetr wound cardiophren angl left pleural caviti stabil patient indic extract projectil left anterior minithoracotomi projectil found success remov pericardium limit pre oper assess optim treatment procedur surgic approach pediatr patient gunshot injuri chest heart discuss
|
D014948;D013898;D005547
|
T020;T037;T072
|
36,282,156
|
effect pre oper routin blood test predict complic acut append earli predict diagnosi perfor acut append allow surgeon choos appropri treatment purpos studi evalu whether pre oper routin laboratori examin role predict complic acut append
|
D002097;D001064
|
T129;T047;T116
|
36,282,155
|
prognost effect nesfatin diagnosi stage acut cholecyst gallbladd diseas import health concern affect approxim popul develop countri acut cholecyst common complic gallston aim studi determin use nesfatin easili applic fast result thought associ inflammatori event diagnosi grade acut cholecyst
|
D041881;D042882
|
T047;T031
|
36,282,154
|
impact establish trauma center blunt traumat spleen injuri treatment comparison pre traumat center trauma center period spleen common injur intra abdomin organ blunt trauma case traumat blunt spleen injuri immedi treatment often requir studi aim investig prognost impact establish trauma center treatment patient blunt trauma injuri spleen
|
D014949;D000007
|
T037
|
36,282,153
|
spontan rectus sheath hematoma three patient covid comput tomographi find pulmonari symptom secondari sever acut respiratori syndrom coronavirus covid infect common present diseas howev known small portion patient sever hemorrhag complic also seen report three case elder women known covid infect develop spontan rectus sheath hematoma anticoagul therapi present three case present emphas need perform comput tomographi examin sudden hemodynam deterior decreas hemoglobin count covid patient intens care unit icus sinc clinic deterior caus spontan rectus sheath hematoma rsh must taken consider examin rshs ruptur abdomin caviti outcom may fatal hour repres two case major spontan hemorrhag covid patient quit uncommon therefor may caus serious complic rare taken consider failur acknowledg risk could signific worsen prognosi patient especi er icus
|
D000086382;D009135
|
T047;T067
|
36,282,152
|
access isoquinolin h yl acetamid isoindolin yl acetamid common mcr precursor achiev diverg synthesi isoquinolin h yl acetamid exampl yield regioselect isoindolin yl acetamid exampl yield moder good yield react various substitut ethanon termin alkyn ugi cr intermedi via ammonia ugi crcopper catalyz annul sequenc reaction intermedi thus give distant close relat scaffold high interest exploit chemistri space receptor scope limit effici sequenc reaction describ well gram scale synthesi
|
D000081
|
T109
|
36,282,148
|
investig streptococcus sinensi compet regulon combin transcriptom analysi phenotyp evalu streptococcus sinensi recent identifi member miti group streptococci speci associ infect endocard howev mechan pathogenesi virul fulli understood studi aim investig influenc compet stimul peptid csp compet regulon quorum sens circuitri comabcd subsequ gene transcript express well result phenotyp studi confirm nativ csp ident ascertain endogen csp produc complet transcriptom wide analysi gene follow csp exposur rna sequenc analysi reveal upregul gene known associ compet biofilm format virul varieti phenotyp assay util assess correl increas mrna express potenti phenotyp respons ultim gain insight effect csp gene express develop phenotyp result indic addit exogen csp aid compet develop success transform yield averag transform effici compar miti group streptococci addit studi need delin effect csp exposur biofilm format virul overal studi provid novel inform regard sinensi provid substanti foundat speci role diseas pathogenesi investig
|
D018085;D001426
|
T123;T116;T028
|
36,282,141
|
puls pick multimod nonlinear optic microscopi nonlinear optic microscopi techniqu map chemic composit biolog sampl label free manner common use nonlinear optic process imag includ multiphoton excit fluoresc mpef second harmon generat shg coher raman scatter crs femtosecond laser typic use mpef shg due requir high peak power excit picosecond laser prefer crs due need high spectral resolut therefor challeng integr crs mpef shg chemic imag develop puls pick strategi base acousto optic modul program duti cycl laser puls train signific increas puls peak power low input averag power approach offer strong enhanc nonlinear optic signal make hyperspectr coher anti stoke raman scatter car microscopi compat mpef shg multimod imag low laser averag power puls pick method also enabl evalu comparison phototox laser puls differ averag peak power level photo perturb biolog sampl evalu use cellular dynam sampl morpholog chang allow select optim laser power best sensit minim phototox
|
D013059;D007834
|
T074;T070;T059;T073
|
36,282,138
|
itgb defici induc dna damag downregul hdac airway epitheli cell stress stimul dna damag airway epithelia exogen disruptor trigger various pulmonari diseas integrin beta itgb structur adhes molecul indic regul process dna damag airway epithelia uniqu long cytoplasm domain subunit
|
D008171;D010126
|
T047;T103
|
36,282,137
|
covid alpha variant b humor memori b cell covid pediatr convalesc studi anti sar cov humor adapt respons covid non vaccin pediatr convalesc controversi evid pediatr popul need
|
D000086382;D000086402
|
T047;T005;T067
|
36,282,136
|
allerg diseas immunodefici children lesson learnt covid pandem statement eaaci section pediatr april covid pandem result half billion peopl infect worldwid million death direct due infect pandem mani short long term pervas effect physic mental health popul allerg diseas among preval noncommunic chronic diseas pediatr popul health care profession research seek answer sinc begin pandem children lower risk develop sever covid die infect allerg diseas associ higher covid sever mortal apart severepoor control asthma pandem disrupt routin health care mani mitig strategi includ limit telemedicin success implement continu deliveri high standard care although children face multitud pandem relat issu allerg condit effect treat remot reduct air pollut lack contact outdoor allergen result improv particular respiratori allergi evid recommend substanti chang usual manag modal allerg condit children includ allergen immunotherapi use biolog allerg children greater risk multisystem inflammatori syndrom develop associ long covid report although data limit research need statement eaaci section pediatr provid recommend base lesson learnt pandem avail evid
|
D000086382;D006967;D001249;D007153
|
T047;T046;T067
|
36,282,135
|
role short term grass pollen exposur food skin prick test reactiv food allergi eczema flare children relationship pollen respiratori allergi well document role short term pollen exposur food allergi eczema flare previous explor aim investig associ popul base sampl children
|
D005512;D004485
|
T047;T046
|
36,282,134
|
valid food allergi qualiti life questionnair seri chines famili food allerg children anxieti accident exposur vigil dietari monitor impair qualiti life qol food allerg patient comprehens food allergi specif questionnair allow patient accur report qol studi valid food allergi qualiti life questionnair faqlq seri assess qol chines food allerg patient caregiv
|
D011788;D005512
|
T078;T046
|
36,282,133
|
earli life residenti exposur moistur damag associ persist wheez finnish birth cohort moistur damag increas risk respiratori disord childhood aim determin whether earli age residenti exposur inspector observ moistur damag mold associ differ wheez phenotyp later childhood
|
D012135;D000089822
|
T201;T184;T033;T098
|
36,282,132
|
pm pm bronchiol sever cohort studi studi suggest particul matter pm exposur might play role bronchiol howev avail data most focus risk hospit come retrospect studi provid conflict result prospect studi investig associ pm pm pm exposur sever bronchiol
|
D000397;D001988;D000393
|
T131;T047;T069;T080
|
36,282,131
|
diagnosi manag food allergi associ gastroesophag reflux diseas young children eaaci posit paper gastro oesophag reflux gor food allergi fa common condit especi first month life gor lead troublesom symptom affect daili function infant famili refer gor diseas gord role food allergen caus gord remain controversi european academi allergi clinic immunolog eaaci posit paper aim review evid fa associ gord young children translat clinic practic guid healthcar profession diagnosi suspect fa associ gord medic dietari manag task forc tf non ige mediat allergi consist eaaci expert paediatr gastroenterolog allergi dietet psycholog europ unit kingdom unit state turkey brazil six clinic question formul amend approv tf guid public systemat literatur search use pubm cochran embas databas june use predefin inclus criteria base question use tf also gain access databas european societi paediatr gastroenterolog hepatolog work group publish guidelin gord ensur public use within posit paper includ question practic point formul follow modifi delphi method consist anonym web base vote repeat modifi practic point requir least consensus practic point achiev tf posit paper share process discuss consensus practic point fa associ gord
|
D005764;D005512
|
T047;T046
|
36,282,127
|
mediat link obes childhood asthma obes asthma high associ mechan under associ remain unknown examin five mediat link obes childhood asthma pulmonari function impair airway inflamm physic fit sleep disord breath sdb earli puberti
|
D001249;D063766
|
T033;T047
|
36,282,119
|
virtual realiti hemifield measur correct surgeri elig ptosi patient pilot clinic trial develop acceler virtual realiti vr suprathreshold hemifield perimetri algorithm median cut hemifield test mcht studi examin abil mcht determin ptosi sever revers artifici improv eyelid tape htc vive pro eye vr headset humphrey visual field analyz hvfa assess capabl emerg technolog evalu ptosi
|
D001763;D000076142
|
T047;T066
|
36,282,118
|
evalu molecular properti versus vivo perform aflibercept brolucizumab ranibizumab retin vascular hyperperm model evalu molecular pharmacokinet pharmacolog properti three anti vascular endotheli growth factor vegf agent aflibercept brolucizumab ranibizumab provid predict optim design intravitr vegf challeng rabbit assess preclin vivo activ differ anti vegf agent
|
D000069579;D002118
|
T129;T121;T123;T116;T196
|
36,282,117
|
season variat diurnal rhythm human eye implic continu ocular growth adolesc young adult investig diurnal rhythm human eye winter summer southeast norway latitud n
|
D002940;D008550
|
T125;T121;T040;T109
|
36,282,112
|
top doubl mass spectrometri histon h proteoform tandem ultraviolet photon mobilitymass select electron captur dissoci post translat modif ptms intact histon play major role regul chromatin dynam influenc biolog process dna transcript replic repair natur posit histon ptm crucial deciph inform translat biolog respons present work potenti novel tandem top doubl approachultraviolet photodissoci follow mobil mass select electron captur dissoci mass spectrometri uvpd tim q ecd tof msms illustr character hela deriv intact histon h proteoform comparison q ecd tof msms spectra tradit fourier transform ion cyclotron reson ecd msms spectra h standard show similar sequenc coverag signific faster data acquisit tof msms platform vs min multipl mass shift eg da observ hela deriv h proteoform top uvpd ecd fragment analysi consist detect presenc acetyl ptms n terminus lys lys lys lys residu well methyl dimethyl trimethyl ptms lys residu high sequenc coverag present top result good agreement bottom tim tof msms experi allow addit descript ptms n terminus integr nm uv laser present platform allow uvpd event prior ion mobil mass precursor separ collis induc dissoci cid ecd tof ms select c uvpd fragment differ h proteoform eg ac ac ac exhibit multipl im band similar cidecd fragment pattern per im band point toward presenc conform adopt ptm distribut clear assign ptm local c uvpd fragment h proteoform result consist biolog zip model acetyl proceed lys lys direct novel platform enhanc structur toolbox altern fragment mechan uvpd cid ecd tandem fast high resolut mobil separ show great promis global proteoform analysi
|
D006657;D053719
|
T063;T123;T116
|
36,282,094
|
function assay evalu immunosuppress mediat myeloid deriv suppressor cell myeloid deriv suppressor cell mdscs heterogen popul immatur myeloid cell divid two main subpopul polymorphonuclear pmn mdscs monocyt mdscs cell accumul chronic inflamm character array patholog cancer inflammatori bowel diseas infecti autoimmun diseas induc immunosuppress suppress effect mdscs immun system studi main focus featur function impact target cell cell natur killer cell b cell among other herein describ method analysi mdsc immunosuppress featur function measur differ mediat contribut activ impact cell function protocol describ continu companion current protocol articl reuven et al use generat singl cell suspens isol cell test activ author current protocol publish wiley period llc basic protocol evalu mdsc suppress featur altern protocol dichlorofluorescein diacet base reactiv oxygen speci detect support protocol detect nitric oxid secret support protocol measur arginas activ basic protocol evalu mdsc suppress function altern protocol vitro effect mdscs express cell receptor complex activ support protocol effect mdscs interferon product basic protocol effect mdscs cell prolifer basic protocol effect mdscs cell cytotox activ altern protocol vivo cytotox assay basic protocol analysi mdsc differenti
|
D000072737
|
T025
|
36,282,090
|
three new speci pseudorhabdosynochus monogenea diplectanida sever speci cephalopholi epinephelus perciform serranida thailand pseudorhabdosynochus suratthaniensi n sp describ gill cephalopholi argus p cephalopholi n sp gill c sonnerati p samaesarnensi n sp gill epinephelus lanceolatus fish caught gulf thailand pseudorhabdosynochus suratthaniensi n sp distinguish congener speci structur sclerot vagina wide sclerot trumpet singl larg primari chamber number row rodlet squamodisc pseudorhabdosynochus cephalopholi n sp also distinguish structur sclerot vagina like p suratthaniensi n sp sclerot trumpet also long coil curv primari canal near midlength distal part primari chamber secondari chamber communic primari chamber short secondari canal addit p cephalopholi n sp distinguish sclerot organ ventral dorsal hamuli ventral bar quadrilocul organ differ length number row rodlet squamodisc pseudorhabdosynochus samaesarnensi n sp distinguish sclerot vagina anterior cup shape trumpet short straight curv primari canal thailand first speci pseudorhabdosynochus describ speci cephalopholi second speci pseudorhabdosynochus describ epinephelus
|
D001492;D014200;D010473;D005393;D014201
|
T047;T204;T013
|
36,282,085
|
evalu learn memori drosophila melanogast studi neurodevelopment impact toxic neurodevelopment disord heterogen group behavior defin disord genet environment risk factor given mani neurodevelopment disord character impair learn andor intellectu abil behavior paradigm assess cognit anim model effect tool delin under genet variant impact diseas pathophysiolog exampl learn memori paradigm common fruit fli drosophila melanogast success use studi risk gene biolog pathway associ sever neurodevelopment disord includ fragil x syndrom autism spectrum disord charg syndrom establish drosophila behavior paradigm histor use investig genet risk factor also mani applic includ use development neurotoxicolog studi determin environment risk factor neurodevelopment disord howev deficit step step protocol describ appli learn memori assay fruit fli development neurotoxicolog studi describ two quantit behavior paradigm drosophila predat induc oviposit courtship condit use measur differ form learn memori context development neurotoxicolog studi non associ learn memori measur examin femal drosophila oviposit behavior respons endoparasitoid wasp associ learn memori measur male use courtship condit protocol outlin procedur oral toxic exposur develop fruit fli cultur endoparasitoid wasp measur drosophila oviposit activ assess condit courtship order identifi impact toxic learn memori femal male exampl present protocol use bisphenol chemic util synthesi polycarbon plastic determin impact learn memori protocol inexpens relat simpl perform use lab new drosophila behavior research evalu toxic exposur influenc learn memori male femal fli wiley period llc basic protocol prepar toxic contain food development exposur basic protocol predat induc oviposit assay support protocol cultur leptopilina heterotoma basic protocol condit courtship assay
|
D000067877;D014863
|
T204;T048
|
36,282,069
|
print enabl uniform temperatur distribut microfluid devic mani microfluid process reli heavili precis temperatur control though intern contain heater develop use tradit fabric method limit abil isotherm heat precis defin volum advanc print led high resolut printer capabl use bio compat materi achiev geometri resolut near print abil creat arbitrari structur arbitrari orient oppos tradit microfluid fabric method enabl new three dimension heater geometri creat exampl demonstr three new heater geometri non planar serpentin channel taper helic channel diamond channel new geometri shown finit element simul isotherm heat microfluid channel cross section c temperatur differ along mm length compar design literatur abl temperatur distanc sever ms final set design rule creat isotherm region base desir temperatur heater pitch heater gradient radial space around target volum detail
|
D056656;D066330
|
T073;T075
|
36,282,062
|
long term prognost impact estim glomerular filtrat rate admiss patient hospit acut heart failur although small sampl size studi shown basal alter estim glomerular filtrat rate egfr relat short mid term higher mortal acut heart failur ahf scarc inform influenc alter egfr long term mortal readmiss therefor multicent studi sought investig relationship egfr admiss ahf long term mortal readmiss larg sampl patient
|
D006333;D051436
|
T047;T046
|
36,282,060
|
normal testosteron level young men rethink ngdl cutoff testosteron defici men year old age relat declin male testosteron product therefor surpris young men evalu testosteron defici cutoff ngdl develop sampl older men aim describ normat total testosteron level age specif cutoff low testosteron level men year old
|
D007006;D013736
|
T047;T191
|
36,282,048
|
preorgan electr field function catalyt cycl case enzym tyrosin hydroxylas natur devis intrins electr field ief engag electrostat catalysi enzym ief target function enzym involv sever reaction step catalyt cycl deciph impact ief catalyt cycl enzym system perform molecular dynam quantum mechanicalmolecular mechan qmmm simul tyrosin hydroxylas tyrh catalyt cycl tyrh involv two reaction stage activ h form activ speci compound cpd first stage cpd mediat hydroxyl l tyrosin l dopa second stage first stage qmmm calcul show heme propion group function base catalyz heterolysi reaction second stage studi reveal reaction initi mediat proton coupl electron transfer follow oxygen atom transfer compound ii cpd ii l tyr substrat import calcul demonstr ief tyrh optim promot bond heterolysi generat activ speci enzym cpd howev ief slow subsequ aromat hydroxyl thus ief tyrh enzym catalyz product format step select boost one challeng step catalyt cycl find general implic h depend metalloenzym expand understand natur use electr field smart reagent modul catalyt reactiv
|
D014446;D011789
|
T170;T126;T116
|
36,282,035
|
preval work relat musculoskelet symptom among young orthoped surgic practic intervent studi work relat muscl skelet symptom wrms repres substanti social econom impact way work high incid surgeon literatur sever studi address impact wrms surgeon perform gynecolog laparoscop robot surgeri studi field orthoped surgeri pilot studi aim assess effect prevent program reduc pain
|
D066231;D019637
|
T061;T097
|
36,282,034
|
incid malign mesothelioma asbesto exposur emilia romagna region itali aim studi describ incid malign mesothelioma mm asbesto exposur italian region period june
|
D001194;D008654;D000086002;D016273;D010997
|
T131;T197;T191;T037
|
36,282,033
|
ocular health among industri worker preval studi foreign bodi injuri refract error dri eye pterygium pinguecula workplac play critic role develop ocular diseas owe risk accid studi aim evalu ocular health industri worker determin preval foreign bodi injuri refract error dri eye pterygiumpinguecula well factor influenc diseas
|
D011625;D015352;D012030;D005547
|
T184;T020;T037;T047;T072
|
36,282,032
|
develop decis aid tool select pen paper observ ergonom techniqu quasi experiment studi signific error may occur ergonom risk assess invalid assess reliabl correspond techniqu select studi aim develop new tool call decis aid tool dat reduc pen paper observ techniqu select error
|
D006804;D016272
|
T078;T090;T058;T091
|
36,282,031
|
long term covid symptom work abil fit work healthcar worker hospit sar cov infect covid affect persist symptom work abil wa henc fit work healthcar worker hcw describ effect covid hospit hcws larg hospit lombardi implic wa fit work
|
D000086382
|
T047;T067
|
36,282,030
|
simultan exposur heat whole bodi vibrat motor skill function citi taxi driver drive requir sensori motor abil unpredict complex drive scenario experiment studi aim investig combin effect exposur whole bodi vibrat heat motor skill function citi taxi driver
|
D014732;D001334
|
T056;T070
|
36,282,028
|
updat estim excess total mortal itali circul ba ba omicron variant april juli impact new lineag sub lineag omicron total excess mortal larg unknown studi aim provid estim excess mortal circul omicron variant itali updat juli
|
D058873;D000086382
|
T047;T067
|
36,282,007
|
novel aryl alkamidazol deriv multifunct antifung inhibitor design synthesi biolog evalu dual target drug design consid reason antifung strategi studi three differ seri novel compound design use skeleton screen splice method base dual target enzym featur structur synthes character among target compound b c excel antifung activ gml select subsequ mechanist studi one hand compound block ergosterol biosynthesi pathway inhibit core enzym cyp effect induc rapid accumul reactiv oxygen speci damag mitochondri function eventu led occurr fungal apoptosi hand compound also inhibit inflammatori induc enzym cyclooxygenas affect express inflammatori factor bodi immun function conclus studi discov potenti target compound could acceler rehabilit process infect region
|
D000935;D015195
|
T090;T121;T195
|
36,282,006
|
cancer cell hijack rna process rewrit messag typic cancer thought aris due dna mutat dysregul transcript andor aberr signal recent becom clear dysregul mrna process mrna export translat also contribut malign rna process event result major modif physic natur mrnas addit methyl guanosin cap remov intron addit polya tail mrna process critic determin protein code capac mrnas sinc physic chang impact effici given transcript export cytoplasm translat protein mani mrna metabol step consid constitut housekeep activ known high regul combinatori multipl impact ie one event influenc capac undergo other furthermor altern splice andor cleavag polyadenyl produc transcript altern messag new function coordin process group function relat rnas potent wire signal pathway modul surviv pathway even structur cell postul rna regulon model combinatori regul group achiev presenc share cis act element known user code recruit machineri process export translat dysregul rna metabol cancer give rise alter proteom turn elicit biolog respons relat malign studi event cancer reveal new mechan underpin malign unearth novel therapeut opportun cancer cell coopt rna process export translat support oncogen activ
|
D026723;D009369
|
T191;T044
|
36,282,004
|
characteris ion channel structur dynam use fluoresc spectroscopi techniqu ion channel undergo major conform chang lead channel open ion conduct deciph structur function relationship paramount understand channel physiolog pathophysiolog cryo electron microscopi crystallographi comput model provid atom scale snapshot channel conform non cellular environ lack dynam inform link function result biophys techniqu electrophysiolog hand provid function data structur inform process involv fluoresc spectroscopi techniqu help bridg gap simultan obtain structur function correl includ voltag clamp fluorometri frster reson energi transfer ligand bind assay singl molecul fluoresc variat techniqu employ unearth sever featur ion channel behaviour instanc provid real time inform local global rearrang inher channel properti also lend insight traffick express assembl ion channel membran surfac method advantag carri either nativ heterolog system review briefli explain principl fluoresc translat studi ion channel function also report sever recent advanc fluoresc spectroscopi help address improv understand biophys behaviour differ ion channel famili
|
D031541;D007473
|
T123;T059;T116
|
36,282,000
|
divers arsenal type iii crispr cas associ carf save effector type iii crispr cas system make use multi subunit effector complex target foreign rna transcript complementari guidecrispr rna crrna base pair target rna special region crrna trigger target rna cleavag also activ characterist cas subunit set motion varieti catalyt activ start product cyclic oligoadenyl coa second messeng molecul messeng molecul activ extens arsenal ancillari effector protein carri appropri sensori domain notabl carf save effector protein respons renew interest type iii crispr cas due extraordinari divers defens invad genet element wherea hand carf save protein studi far mani seem provok abort infect aim kill host provid popul wide immun defin featur effector protein varieti silico predict catalyt domain fuse mini review discuss current character type iii associ carf save effector protein highlight exampl predict carf save protein interest predict catalyt activ specul could contribut type iii immun
|
D064130
|
T123;T116
|
36,281,999
|
erk immun signal extracellular signal relat kinas erk final compon mitogen activ protein kinas mapk phosphoryl cascad integr modul divers array signal pathway shape cell behaviour fate recent studi shown erk play essenti role downstream immun receptor elicit inflammatori gene express respons infect cell tissu damag much work studi erk activ toll like receptor tlr pathway provid mechanist insight recruit compartmentalis activ cell innat immun system review summaris typic activ erk growth factor receptor pathway discuss known role immun cell signal focus downstream tlrs examin emerg research uncov evid dysfunct erk signal inflammatori diseas discuss potenti therapeut benefit target erk pathway inflamm
|
D020935;D048049
|
T126;T116;T044
|
36,281,996
|
cross determin exciton coher length j aggreg coher length frenkel exciton n coh one critic paramet govern mani key featur supramolecular j aggreg determin experiment valu n coh nontrivi task sinc sensit techniquemethod appli caus discrep literatur data even chemic compound aggreg condit use combin differ experiment techniqu includ uv vis nir fluoresc emiss time resolv photoluminesc transient absorpt spectroscopi determin n coh valu j aggreg cyanin dye found absorpt spectroscopi alon wide use techniqu fail determin right valu n coh correct approach base modif photoluminesc lifetim nonlinear respons upon aggreg care analysi stoke shift electron phonon coupl strength approach reveal n coh jc j aggreg rang
|
D004396;D011804
|
T197;T130;T109
|
36,281,993
|
transcript plastic fibroblast heart diseas cardiac fibroblast play essenti role maintain structur framework heart upon stress fibroblast undergo cell state transit activ fibroblast also refer myofibroblast high synthet cell type prolifer migrat secret extracellular matrix well signal factor modul cellular crosstalk j clin invest e activ fibroblast critic regul cardiac wound heal injuri excess persist activ promot tissu fibrosi hallmark featur patholog remodel heart much previous work cardiac fibroblast biolog focus role canon signal pathway compon extracellular matrix recent effort focus deciph gene regulatori principl govern fibroblast activ better understand molecular mechan trigger sustain fibrot process heart diseas potenti acceler develop therapi specif target cardiac activ fibroblast moment unavail concis review focus mechan under chromatin transcript regul cardiac fibroblast activ discuss recent work group other space highlight applic singl cell genom character fibroblast function divers provid overview prospect target cardiac fibroblast heart diseas associ challeng
|
D005347;D006331
|
T047;T025
|
36,281,990
|
metallacyclosilan calcium yttrium iron util choic oligosilanylen diid possibl synthes number heterocyclosilan heteroel calcium yttrium iron metathesi reaction respect metal halid cai ycl febr si nmr spectroscop analysi calcacyclosilan suggest compound retain strong oligosilanylen dianion charact pronounc analog magnesacyclosilan electroneg calcium lie potassium magnesium silyl calcium reagent consid build block attract reactiv profil reaction oligosilanylen diid ycl gave five member yttracyclosilan ate complex two chlorid still attach yttrium atom reaction obtain compound two equival nacp led anoth five member yttracyclosilan ate complex yttracen fragment use dianion oligosilanylen ligand contain siloxan unit siloxan oxygen act addit coordin site ca ligand use prepar cyclic ferra oxatetrasilacyclohexan analog transannular interact iron oxygen atom miss
|
D007501;D015019
|
T123;T196;T121
|
36,281,989
|
wearabl pressur sensor array layer layer assembl mxene nanosheetsag nanoflow motion monitor human machin interfac recent wearabl sensor electron skin system becom preval employ detect movement status physiolog signal wearer pressur sensor compos mesh like micro convex structur polydimethylsiloxan pdms mxene nanosheetag nanoflow agnf film flexibl interdigit electrod design layer layer lbl assembl uniqu microstructur pdms effect increas contact area improv sensit moreov agnf introduc mxene bridg synergist effect two enhanc perform sensor pressur sensor high sensit kpa good stabil cycl fast responserecoveri time ms ms low detect limit pa use round monitor human bodi sens array integr wireless transmitt intellig artifici electron skin spatial pressur map human comput interact sens moreov develop smart glove simpl method combin model wireless accur detect hand pose provid idea hand somatosensori detect technolog lead health monitor intellig rehabilit train person medicin
|
D000076251
|
T073
|
36,281,987
|
singl cell transcriptom planaria new tool allow new insight cellular evolutionari featur singl cell transcriptom revolutionis biolog allow quantif gene express individu cell sinc singl cell contain cell type specif mrnas techniqu enabl classif cell ident therefor singl cell method use explor repertoir cell type singl cell atlas differ organ includ freshwat planarian nowaday planarian one promin anim model singl cell biolog studi singl cell level decad use avail singl cell methodolog approach includ plate base method qpcr nanodroplet method situ barcod method studi good pictur planarian cell type differenti trajectori planarian regen properti characterist development plastic capac reproduc asexu ensur anoth decad singl cell biolog planarian yet come review characterist new biolog insight obtain singl cell transcriptom outlin perspect futur
|
D010932;D039904
|
T025;T204
|
36,281,986
|
dynam phagocytosi mediat phosphatidylserin phagocytosi trigger phospholipid phosphatidylserin ps key remov apoptot cell develop tissu homeostasi infect modul ps mediat phagocytosi attract target therapeut intervent context atherosclerosi neurodegen diseas cancer wherea mechan target recognit lipid protein signal cytoskelet remodel opsonin driven mode phagocytosi increas well understood ps mediat phagocytosi remain elus partial due involv multitud receptor least redund function complic dissect contribut result complex downstream signal network review focuss receptor involv ps recognit signal cascad connect receptor cytoskelet remodel requir phagocytosi recent progress understand phagocyt cup format coordin ps mediat phagocytosi
|
D010718;D019636
|
T047;T109
|
36,281,969
|
combin transgenesi paratransgenesi fight malaria malaria among deadliest infecti diseas plasmodium causat agent need complet complex develop cycl vector mosquito transmiss occur two promis strategi curb transmiss transgenesi consist genet engin mosquito express antimalari effector molecul paratransgenesi consist introduc mosquito commens bacteria engin express antimalari effector molecul although approach restrict parasit develop mosquito known effect compar provid depth assess transgenesi paratransgenesi evalu combin two approach use q system drive gene express engin mosquito produc secret two effector scorpin mp peptid mosquito gut salivari gland also engin serratia commens bacterium capabl spread mosquito popul secret effector mosquito gut wherea mosquito base bacteria base approach strong reduc oocyst sporozoit intens substanti stronger reduct plasmodium falciparum develop achiev transgenesi paratransgenesi combin import transmiss plasmodium berghei infect nave mice maxim inhibit combin two approach combin two strategi promis becom power approach combat malaria
|
D000962;D000852;D008288
|
T121;T047;T204
|
36,281,966
|
start sexual intercours associ increas cervicovagin immun mediat young women prospect studi meta analysi adolesc girl young women agyw high risk sexual transmit infect stis unknown whether begin sexual intercours result chang immun mediat cervicovagin tract contribut risk
|
D012749;D015658
|
T047
|
36,281,953
|
electroconvuls therapi improv psychot symptom patient dementia lewi bodi aim studi examin efficaci safeti electroconvuls therapi ect psychot symptom dementia lewi bodi dlb also determin use adapt criterion
|
D004565;D020961;D011618
|
T061;T047;T048
|
36,281,950
|
protein glutaminas engin base isotherm compress perturb enhanc modif soy protein isol protein glutaminas play signific role futur food eg plant base meat process result abil improv solubl foam emulsifi gel properti plant base protein howev poor stabil activ high pressur high shear process environ hinder applic therefor develop applic orient method isotherm compress perturb engin strategi improv enzym perform simul high pressur environ best variant remark improv specif activ half time nmqhte exhibit fold increas compar wild type specif activ unitsmg fold increas half time min one highest comprehens perform ever report solubl soy protein isol deamin nmqhte mutant higher deamin wild type tinier particl size coarser textur overal strategi potenti improv function perform enzym complex food process condit
|
D030262;D005972
|
T123;T121;T126;T116
|
36,281,949
|
regul epigenet chang ferroptosisassoci cancer review occurr tumor associ upregul downregul certain gene identif novel tumor therapi reveal regul tumor cell death either promot suppress occurr develop tumor irondepend lipid free oxygen radic accumul caus tumor cell die ferroptosi form regul cell death multipl mechan mediat mode cell death includ redox homeostasi iron metabol mitochondri activ breakdown amino acid lipid sugar epigenet regulatori diseaseassoci signal pathway present review discuss epigenet mechan ferroptosi aim provid novel insight optim effect antitumor therapi
|
D000079403;D009369
|
T191;T043
|
36,281,948
|
potenti vegfr express predict marker pd blockad patient advanc nsclc angiogenesi serv crucial role cancer progress vascular endotheli growth factor vegf exhibit immunosuppress function patient cancer howev remain unclear whether express vegf tumor tissu predict outcom program death blockad patient advanc nonsmal cell lung cancer nsclc train n valid n cohort patient advanc nsclc receiv firstlin pembrolizumab enrol immunohistochem stain vegf receptor vegfr tumorinfiltr lymphocyt til cd cd foxp perform tumor specimen cohort associ clinic outcom assess percentag high vegfr express train cohort valid cohort statist signific differ object respons high low vegfr express observ train vs valid vs cohort posit rate intratumor foxp signific associ high vegfr express valid cohort train cohort valid cohort high vegfr express patient nonadenocarcinoma nonac signific correl posit foxp til intratumor stromal site cd cd high vegfr express cohort indic signific wors overal surviv os low vegfr express vegfr identifi independ prognost marker associ wors os high vegfr express signific marker predict wors os patient treat firstlin pembrolizumab particular nonac
|
D002289;D008175
|
T191
|
36,281,945
|
pedf inhibit nonsmal cell lung cancer prolifer suppress autophagi downregul ampkulk signal current investig suggest pigment epithelialderiv factor pedf mediat progress nonsmal cell lung cancer nsclc regul autophagi howev under mechan associ autophagi remain poor elucid aim present studi investig associ pedfadenosin monophosphateactiv protein kinas ampk unc like autophagyactiv kinas ulk pathway autophagi nsclc intracellular autophagi evalu use indic express activ microtubuleassoci protein light chain lci lcii p well distribut number autophagosom observ confoc microscopi addit activ prolif capac nsclc cell pedf overexpress also examin use cell count kit lactat dehydrogenas ldh assay western blot wb relat protein result reveal pedf signific inhibit nsclc cell prolifer viabil increas ldh releas intercellular adhes furthermor pedf suppress express activ lc reduc number distribut autophagosom pedfinduc inhibit autophagi exhibit direct associ suppress prolifer capac cell viabil nsclc cell result wb show nsclc cell regul autophagi ampkulk signal pathway pedf downregul ampkulk signal pathway ampk ulk overexpress mark reduc inhibitori effect pedf autophagi conclus pedf overexpress signific inhibit prolif capac cell viabil nsclc cell pedf exert inhibitori function regul autophagi nsclc cell final demonstr autophagi may suppress inhibit ampkulk signal pathway therebi reveal mechan lung cancer progress
|
D002289;D008175
|
T191
|
36,281,943
|
enhanc label free nanoplasmon cytokin detect sar cov induc inflamm use ration design peptid aptam rapid precis serum cytokin quantif provid immens clinic signific monitor immun status patient rapid evolv infectiousinflammatori disord examplifi ongo sever acut respiratori syndrom coronavirus sar cov pandem howev real time inform predict cytokin biomark guid target immun pathway pathogen inflamm critic lack insuffici detect rang detect limit current label free cytokin immunoassay work report high sensit local surfac plasmon reson imag lspri immunoassay label free interleukin il detect util ration design peptid aptam captur interfac benefit characterist smaller dimens direct function sens surfac via au bond peptid aptam base lspri immunoassay achiev enhanc label free serum il detect record break limit detect pgml wide dynam rang order magnitud valu pgml observ immunoassay valid vitro label free analysi sar cov induc inflamm appli rapid quantif serum il profil covid patient peptid aptam lspri immunoassay demonstr great potenc label free cytokin detect unpreced sens capabl provid accur time interpret inflammatori status diseas progress determin prognosi
|
D052158;D000086382;D015374
|
T116;T075;T067;T059;T047
|
36,281,942
|
melanoma metastasi role melanin play review melanoma extrem aggress form skin cancer spread lung brain liver among vital organ melanoma cell unlik cancer cell produc signific amount melanin process known melanogenesi caus becom heavili pigment melanogenesi specif melanin pigment well known abil protect skin harm effect uv light lead develop skin cancer nevertheless uncontrol melanogenesi play role advanc melanot melanoma melanin pigment reduc effect radiotherapi immunotherapi therefor studi perform focus inhibit melanogenesi prevent melanoma metastasi howev worth note addit uvprotect function melanin also play role prevent melanoma metastasi microphthalmiaassoci transcript factor mitf melanin demonstr attenu aggress melanoma suppress numer essenti metastat process eumelanin pheomelanin two type melanin caus oxid stress also prevent melanoma progress earli stage henc vital explor role induc melanogenesi rather inhibit melanogenesi prevent melanoma metastasi
|
D008545;D012878
|
T191
|
36,281,939
|
antitumor effect antiepilept drug malign glioma cell patient glioblastoma frequent suffer epilept seizur often requir anticonvuls therapi treatment cours present studi investig four common antiepilept drug perampanel carbamazepin cbz sodium valproat vpa levetiracetam lev expect antitumor effect determin benefici drug treatment malign glioma compar antitumor effect inhibit cell prolifer suppress migrat invas use transwel assay inhibit cell growth investig use six malign glioma cell line tg umg umg yh signific inhibit cell prolifer observ six cell line treat perampanel three cell line treat cbz four cell line treat vpa two cell line treat lev therapeut blood concentr level drug use antiepilept antitumor effect combin temozolomid investig use tg umg cell line confirm cell line perampanel tg cell lev observ cbz vpa cell migrat signific suppress tg umg cell line perampanel cbz vpa lev investig mechan perampanel suppress migrat malign glioma cell express mrna relat epithelialmesenchym transit follow perampanel treatment analyz use revers transcriptionquantit pcr tg umg cell line express rac rhoa constitut cytoskeleton enhanc cell motil reduc cell line furthermor express mesenchym marker ncadherin promot cell migrat infiltr decreas express epitheli marker ecadherin strengthen cellcel adhes reduc cell motil increas furthermor express matrix metalloproteinas proteolyt enzym reduc effect may reduc cell motil increas adhes cell suggest perampanel treatment suppress cell migrat conclus present studi suggest perampanel may benefici term antitumor efficaci antiepilept drug treatment malign glioma
|
D000927;D005910
|
T121;T191
|
36,281,935
|
long noncod rna linc hinder decidu endometri stromal cell endometriosi relev endometri recept emerg data indic long noncod rnas lncrna associ pathogenesi endometriosi howev associ endometriosisassoci infertil addit best knowledg role lncrnas decidu format window implant endometriosi report date base previous result aim present studi explor role lncrna long intergen nonprotein code rna linc vitro decidu endometri stromal cell endometriosi window implant well explor biolog function linc regul disintegrin metalloproteinas thrombospondin motif adamt hsamicrorna mir hsamir decidu endometri stromal cell endometriosi use miranda pita rnahybrid present studi predict mir share common target gene adamt linc exist regulatori target dual luciferas vector construct extract plasmid measur relat fluoresc valu order estim target regulatori associ linc adamt mir midsecretori endometri tissu collect women endometriosisassoci infertil tissu endometri stromal cell extract cultur primari cultur medroxyprogesteron acet mpa bromoadenosin cyclic monophosph brcamp ad induc vitro decidu knockdown linc transfect hsamir mimic time revers transcriptionquantit pcr western blot conduct compar differ gene express experiment negat control group regulatori site linc hsamir identifi howev potenti regulatori site detect hsamir untransl region utr adamt wherea neither utr linc utr adamt regulatori target hsamir process decidu endometri stromal cell vitro induct express hsamir knockdown group signific higher compar negat control group lincknockdown express adamt transfect group signific lower compar negat control group hsamir mimic transfect conclus hypothes linc play notabl regulatori role decidu endometri stromal cell women endometriosi window implant abnorm express may lead declin endometri recept recurr abort
|
D004715;D062085;D001802;D035683;D007246
|
T121;T123;T191;T033;T114;T047;T046
|
36,281,934
|
spectroscop mechanist insight solvent mediat excit state proton transfer aggreg induc emiss introduct methyl group onto hydroxyphenyl benzoxazol excit state intramolecular proton transfer esipt reaction play import role biolog materi relat field esipt base compound prove improv effect fluoresc quantum yield red shift emiss wide separ absorpt emiss wavelength larg stoke shift lss solvatochrom benzoxazol base probe hydroxi methylphenyl benzoxazol hbo pch exhibit typic dual fluoresc phenomenon via esipt reaction non polar weak polar solvent emiss band normal nm tautom nm form identifi assign base fluoresc spectroscopi quantum chemic theoret calcul solvatochrom confirm esipt reaction inhibit solvent polar intermolecular hydrogen bond intramolecular revers combin time depend densiti function theoret calcul reveal emiss strengthen mechan esipt coupl aggreg induc emiss aie mix watermethanol solvent thus strategi provid insight design potenti esipt aie fluoresc sensor
|
D011522;D001583
|
T196;T109
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.