PMID
int64 35.7M
36.4M
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36,273,036
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multicohort geometr deep learn studi age depend cortic subcort morpholog interact fluid intellig predict relationship human brain structur cognit function complex relationship differ childhood adulthood poor understood one strong hypothesi suggest cognit function fluid intellig gf depend prefront cortex pariet cortex work develop novel graph convolut neural network gcnns analysi local anatom shape predict gf morpholog inform cortic ribbon subcort structur extract weight mris within two independ cohort adolesc brain cognit develop studi abcd age year children human connectom project hcp age year predict combin cortic subcort surfac togeth yield highest accuraci gf abcd r hcp dataset r outperform state art predict gf brain measur literatur across dataset morpholog amygdala hippocampus nucleus accumben along tempor pariet cingul cortex consist drove predict gf suggest signific refram relationship brain morpholog gf includ system involv rewardavers process judgment decis make motiv emot
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D000077321;D063132
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T017;T091;T066
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36,273,034
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oral express function analys extracellular calcium sens receptor casr chicken vertebr extracellular calcium sens receptor casr play key role calcium homeostasi sens slight chang extracellular ca casr also express mammal includ rodent tast cell involv sens kokumi rich savori qualiti enhanc intens salti sweet umami tast studi focus chicken casr ccasr sinc calcium essenti nutrient necessari make eggshel extrem rapid initi growth bone first confirm ccasr express tast cell next clone ccasr gene kidney transient transfect human embryon kidney hekt cell recombin ccasr empti vector look agonist alloster modul includ kokumi substanc ccasr ca imag found ccasr activ extracellular ca mg dose depend manner sever l amino acid kokumi substanc glutathion enhanc respons ccasr addit nps negat alloster modul human casr negat modul respons ccasr result suggest ccasr sens extracellular ca mg well posit negat alloster modul taken togeth result impli casr might multifunct receptor calcium amino acid kokumi substanc chicken present find function casr express chicken oral tissu allow us elucid physiolog role casr chicken tast sens creat new feed contribut poultri industri
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D044169;D002645
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T116;T012;T192
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36,273,033
|
mandarin biochar teta mbt prepar citrus reticulata peel adsorpt acid yellow dye water dehydr techniqu sulfur acid use creat novel biochar mandarin peel wast follow condens triethylenetetramin teta give mandarin biochar teta mbt bjh bet ftir sem dsc tga edx studi use characteris mbt capac newli develop biochar remov acid yellow ay dye water solut studi ph ay dye adsorpt found best ph use ppm ay dye begin concentr g l mbt dose greatest percent ay dye remov mbt mbt calcul maximum adsorpt capac q mg g langmuir lim freundlich fim tempkin tim dubinin radushkevich drim isotherm model appli analys experiment data furthermor result isotherm model investig various known error function equat mbt experiment data best suit lim pseudo first order pfo pseudo second order pso elovich kinet model ekm intraparticl diffus ipd film diffus fd model use calcul kinet data pso rate model high correl r use assess adsorpt rate main mechan mbt adsorpt method ay dye anion adsorpt electrostat attract forc aris increas posit charg site acid medium obtain data suggest prepar mbt adsorb potenti effect materi remov ay dye water may use repeat without lose adsorpt effici
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D014874;D002957
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T131;T168;T002
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36,273,032
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vitamin enhanc type ifn signal covid patient abil vitamin vitd modul antivir respons induct antimicrobi peptid well establish howev effect vitd host respons sar cov well investig report abil vitd enhanc host ifn alphabeta signal vitro among sever covid patient treat vitd blood saliva specimen obtain sever covid patient treat patient patient vitd stay intens care unit patient follow day follow admiss patient surviv outcom collect higher activ level rig mda jak stat signal pathway observ signific higher gene protein level antivir interferon stimul gene isg mx isg vitro follow treatment pbmcs vitd whole blood saliva specimen vitd treat patient moreov vitd treat patient lower risk caus mortal day compar untreat patient adjust hazard ratio confid interv p herein uncov regulatori role vitd type ifn suggest import insur normal level vitd prevent probabl treatment sar cov infect addit mechanist studi howev need fulli elucid antivir effect vitd particular set covid infect
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D000086382
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T047;T067
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36,273,031
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hydrogel base microfluid devic multiplex vitro cell cultur microfluid devic combin extracellular matrix environ cell physiolog relev perfus advantag cell cultur platform develop hydrogel base microfluid cell cultur platform load polyethylen glycol peg hydrogel encapsul u glioblastoma cell membran cap well polydimethyl siloxan pdms multilay microfluid cell cultur system combin previous report design featur configur load biomimet perfus array cell cultur chamber one dimens array fed microfluid concentr gradient generat mcgg orthogon dimens provid load channel fill row cell cultur chamber separ layer contrast typic tree like mcgg mixer fraction serial dilut initi solut concentr achiev tailor input microchannel width hydrogel effici reproduc load well cell even distribut throughout hydrogel maintain viabil day drug screen assay diffus temozolomid carmustin hydrogel encapsul u cell perfus solut measur dose respons curv generat demonstr util vitro mimic glioblastoma microenviron
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D020100;D005909
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T122;T191
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36,273,030
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identif function interpret mirna affect rare cnvs cakut rare copi number variant cnvs among common genom disord under cakut mirna locat rare cnvs repres well found function variant human cakut research studi aim identifi function interpret mirna frequent affect rare cnvs cakut estim overal burden rare cnvs mirna gene cakut addit aim studi experiment confirm effect rare cnv cakut candid mirna express subsequ chang mrna level select target gene databas cakut associ rare cnv region creat literatur mine use map mirna precursor mirna mirna famili frequent affect rare cakut associ cnvs subject bioinformat analysi cnv burden analysi perform identifi chromosom overunderrepresent mirna gene rare cnvs associ cakut function studi perform hek mir ko hek wt cell line follow analysi relat mirna mrna target gene level cakut patient under rare cnv least one mirna gene overlap identifi cnv network analysi frequent affect mirna reveal domin regul two mirna hsa mir hsa mir p addit mir famili member shown substanti enrich rare cnvs cakut overunderrepresent mirna gene rare cnvs associ cakut observ multipl chromosom chr chr chr signific fold downregul hsa mir follow notabl upregul mdm apaf downregul notch detect hek mir ko compar hek wt cell line support studi hypothesi mirna gene frequent affect rare cnvs cakut patient understand potenti cnv affect mirna particip cakut genet driver repres crucial implic develop novel therapeut approach
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D056915;D035683
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T045;T123;T114;T086
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36,273,028
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optim purif character xylanas product newli isol trichoderma harzianum strain two step statist experiment design strategi xylanas hydrolyt enzym wide rang applic sever industri biofuel paper pulp food feed object studi optim cultur condit medium compon maxim xylanas product newli isol trichoderma harzianum strain use plackett burman design pbd box behnken design bbd experiment strategi xylanas product enhanc fold uml bbd compar preliminari one factor time ofat activ uml fold compar pbd uml optim condit xylanas product day ferment incub temperatur c ph agit rpm wheat bran ammonium sulphat experiment design effect provid condit product acid thermost enzym excit potenti applic anim feed improv acid thermost xylanas purifi submerg cultur sds page analysi reveal molecular weight kda protein maximum xylanolyt activ ph c stabl h retain activ exhibit substrat specif beechwood xylan k mgml v max molminmg enzym activ enhanc fe mg zn absenc strong inhibitor xylanas activ overal characterist indic potenti least two industri applic
|
D043364;D014990
|
T126;T116;T109
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36,273,027
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haplotyp pharmacogen use tla combin illumina nanopor sequenc current use pharmacogenet genotyp assay offer limit haplotyp inform potenti caus specif function effect miss studi test target locus amplif tla use non patient specif primer combin illumina nanopor sequenc offer advantag term accur phase tla method select amplifi sequenc entir gene base crosslink dna close physic proxim way dna fragment initi apart genom ligat one molecul make possibl sequenc distant variant within one short read studi four pharmacogen cypd cypc cypa brca sequenc enrich use differ primer pair nucleotid map target use illumina nanopor sequenc respect averag depth x region interest none gene entir cover either sequenc method three four gene less half variant phase correct compar refer nanopor dataset optim primer pair cypd result correct haplotyp show method use reliabl genotyp phase pharmacogen requir patient specif primer design optim effect
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D000081414
|
T063
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36,273,026
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nanoscal analysi frozen honey atom probe tomographi three dimension reconstruct analys volum one main goal atom probe tomographi apt deliv near atom resolut nm spatial resolut chemic inform mass sensit ppm rang extend techniqu frozen biolog system would enorm impact structur analysi biomolecul previous work shown possibl measur frozen liquid apt paper demonstr abil apt trace nanoscal precipit frozen natur honey mass signal common sugar fragment c x h c x h z overlap h n h water achiev correct stoichiometr valu via differ interpret approach peak thus determin water content reliabl next use honey investig spatial resolut capabl step toward measur biolog molecul solut sub nanomet resolut may take analyt techniqu new level sinc method chemic character cryogen sampl especi biolog sampl still limit
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D006722
|
T168
|
36,273,024
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comparison three dimension bodi centr mass trajectori locomot zero one dimension statist trajectori bodi centr mass bcom locomot differ speed gait patholog state statist method need compar among differ condit ten particip walk treadmil ms bcom trajectori obtain stereophotogrammetri express fourier seri trajectori compar among speed use zero dimension linear circular test differ amplitud phase fourier seri harmon ii one dimension statist parametr map spm test anteroposterior mediolater vertic axial compon bcom trajectori iii spm hotel test three dimension bcom trajectori increas speed increas amplitud decreas phase fundament nd vertic harmon coher bcom vertic trajectori featur greater displac forward shift combin greater displac along anteroposterior axi hotel spm whole trajectori featur supra threshold cluster transit doubl singl support mid singl support test yield coher complementari result spm hotel suitabl compar whole three dimension bcom trajectori howev research hypothes condit may impact specif harmon axial compon spm test recommend
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D008124;D005684
|
T033;T040
|
36,273,023
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singleplex multiplex pool sampl real time rt pcr assay detect sar cov occup medicin set workplac oper telework remot critic need routin occup sar cov diagnost test although diagnost test includ cdc novel coronavirus ncov real time rt pcr diagnost panel cdc diagnost panel eua made avail earli pandem resourc scarciti high demand reagent equip necessit prioriti symptomat patient clear defin need flexibl test methodolog strategi rapid turnaround result symptomat asymptomat high risk exposur asymptomat popul without preexist condit routin screen address need site work forc develop distinct sar cov diagnost assay base origin cdc diagnost panel eua yet minimum overlap current employ reagent elimin direct competit limit resourc pandem progress test load increas modifi assay includ sampl pool amplicon target multiplex analyt sensit pool multiplex assay rigor test contriv posit sampl realist patient background assay perform determin clinic sampl previous assess fda author assay throughout pandem success test symptomat known contact travel within occup popul h turnaround time limit spread covid workplac singleplex assay detect limit copi per reaction three color multiplex assay maintain similar sensit singleplex assay tripl throughput pool assay increas throughput five fold singleplex assay albeit subtl loss sensit subsequ develop hybrid multiplex pool strategi test address need rapid analysi sampl personnel high risk covid infect routin screen herein sar cov assay specif address need occup healthcar rapid analysi personnel high risk infect routin screen essenti control covid diseas transmiss addit sar cov covid work demonstr success flexibl assay develop deploy implic emerg high transmiss diseas futur pandem
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D000086382;D009787
|
T047;T091;T067
|
36,273,022
|
develop forecast model covid hospit admiss use anonym aggreg mobil network data reliabl forecast covid hospit admiss near term horizon help enabl effect resourc manag vital reduc pressur healthcar servic use mobil network data come attent respons covid pandem leverag abil captur peopl social behavior crucial show latent featur irrevers anonym aggreg mobil network data carri use inform relat spread sar cov virus describ develop forecast model use featur predict covid hospit admiss near term horizon day case studi verifi approach two hospit sweden sahlgrenska univers hospit sdra lvsborg hospit work close expert engag hospit resourc plan import result forecast model use year logistician hospit one main input decis regard resourc manag
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D000086382;D008962
|
T062;T047;T170;T067
|
36,273,020
|
effect smoke quantif aortic stiff ultrasound time harmon elastographi smoke signific cardiovascular risk factor caus stiffen central arteri especi aorta vessel stiff determin indirect measur puls wave veloc elastographi allow imag base determin vessel stiff time provid inform vascular morpholog studi compar abdomin aortic wall stiff measur ultrasound time harmon elastographi fifteen smoker fifteen age match non smoke control without histori cardiovascular diseas smoker signific higher abdomin aortic wall stiff mean shear wave speed ms confid interv ci ms compar ms ci ms p group non smoker baselin characterist includ aortic diamet show signific differ inter rater variabl excel intraclass correl coeffici ci result show sensit subclin stiffen aorta young middl age smoker even morpholog chang occur may therefor potenti serv screen tool earli aortic abnorm longitudin risk factor cardiovascular health
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D059289;D054459
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T060;T047;T046
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36,273,019
|
dft calcul h c nmr chemic shift methyl phenyl phenyldiazenyl h pyrazol amin solut geometri methyl phenyl phenyldiazenyl h pyrazol amin azo dye compound tautom optim use blyp x function coupl tzvp g p basi set h c nmr chemic shift speci predict use densiti function theori dft approach coupl tzvp g p basi set differ optim geometri appli use giao method use eight geometri select function character differ amount hartre fock exchang select dft method blyp x bp bxd tpsstpss pbepb cam blyp wbxd lsda hsehpb pwpw lc wpbe bpw result obtain compar avail experiment data use differ statist descriptor root mean squar error rmse maximum absolut error mae result reveal predict h nmr chemic shift signific depend appli geometri predict c nmr chemic shift among examin function bd tpsstpss function found accur one x function least accur one result also reveal predict nmr chemic shift use tzvp basi set result accur result g p basi set
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D008279
|
T060;T170;T059
|
36,273,017
|
evid visual crossmod reorgan posit relat speech outcom cochlear implant user deaf individu use cochlear implant ci remark differ outcom auditori speech communic abil one factor assum affect ci outcom visual crossmod plastic auditori cortex depriv auditori region begin support non auditori function vision previous research view crossmod plastic harm speech outcom ci user interfer sound process other demonstr plastic relat visual languag may benefici speech recoveri clarifi use electroencephalographi eeg measur brain respons partial face speak silent singl syllabl word visual languag ci user age match typic hear control use sourc analysi eeg activ measur crossmod visual respons auditori cortex compar ci user speech nois listen abil ci user brain respons onset video stimulus face larger control left auditori cortex consist crossmod activ deaf ci user also produc mixtur alpha hz synchron desynchron auditori cortex watch lip movement control instead show desynchron ci user higher speech score stronger crossmod respons auditori cortex onset video lower speech score increas alpha power lip movement auditori area therefor evid crossmod reorgan ci user necessarili predict poor speech outcom differ crossmod activ lip read may instead relat strategi differ ci user use audiovisu speech communic
|
D003054;D003638;D013067;D019929
|
T061;T184;T033;T047;T074;T041
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36,273,016
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silico evalu endors molecular method detect drug resist tuberculosi univers drug suscept test dst tuberculosi major goal end tb strategi pcr base molecular diagnost test instrument increas dst global sever assay endors world health organ use diagnosi drug resist endors assay howev interrog limit number mutat associ resist potenti limit sensit compar sequenc base method appli silico method compar sensit specif endors molecular base diagnost mutat set identifi mutat catalogu use phenotyp dst refer found silico mutat set use probe base molecular diagnost test identifi rifampicin isoniazid pyrazinamid levofloxacin moxifloxacin amikacin capreomycin kanamycin resist produc similar sensit specif mutat catalogu pcr base diagnost test sensit drug mechan resist well establish localis small genet region preval mutat approach use sequenc technolog provid advantag drug knowledg resist limit complex resist signatur exist
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D009169;D018088
|
T047;T007
|
36,273,015
|
biogeographi eye size evolut ogr face spider net cast spider deinopida compris charismat famili enigmat evolutionari histori describ speci deinopid place among three genera deinopi menneus asianopi distribut global throughout tropic subtrop deinopi asianopi ogr face spider best known giant light captur posterior median eye pme wherea menneus enlarg pmes molecular phylogenet studi reveal discord morpholog molecular data employ charact rich ultra conserv element uce dataset taxon rich cytochrom oxidas coi dataset reconstruct genus level phylogeni deinopida aim investig group histor biogeographi examin pme size evolut although phylogenet result support monophyli menneus singl reduct pme size deinopid data also show deinopi monophylet consequ formal transfer deinopi speci asianopi transfer compris african australian south pacif subset central american mexican speci follow diverg eastern western deinopid cretac deinopisasianopi dispers africa asia australia biogeograph histori reflect separ western gondwana well long distanc dispers event
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D013112
|
T204
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36,273,014
|
lignin activ compon corn silk water extract inhibit glycat format advanc glycat end product associ age diabet complic neuropathi retinopathi nephropathi thus suppress age format could prevent andor treat relat disord corn silk use tradit medicin prevent diabet complic treatment edema japan china previous studi reveal anti glycat activ flavonoid methanol extract corn silk anti glycat activ corn silk water extract higher methanol extract howev activ compon water extract remain unidentifi purpos studi make clear compon show anti glycat activ corn silk water extract elucid structur characterist evalu anti glycat activ carri enzym link immunosorb assay detect glycat bovin serum albumin remark anti glycat activ observ kda fraction revers phase hplc analysi fraction show broad peak characterist high molecular weight polyphenol decomposit reaction provid evid condens acid hydrolyz tannin therefor polyphenol contain corn silk water extract consid lignin carbohydr complex h c nuclear magnet reson nmr fourier transform infrar ft ir spectroscopi spectra kda fraction agreement valu report lignin consequ conclud lignin carbohydr complex one activ compon glycat corn silk water extract
|
D008031;D003313
|
T123;T168;T002;T109
|
36,273,013
|
understand associ matern high risk fertil behaviour child nutrit level india evid nation famili health survey anthropometr marker import aspect child health assess use larg scale nation repres data nation famili health survey nfhs studi aim investig relationship children born women high risk fertil behaviour children health outcom sampl consist children current marri women age year india key explanatori variabl high risk fertil behaviour defin women age birth year birth interv less month higher birth order four key outcom variabl assess child health outcom stunt wast underweight children age month use descript statist pearson chi squar test logist regress model analys object approxim children born singl high risk condit last year india bivari analysi show three compon child health stunt wast underweight higher among children born women high risk fertil behaviour find multivari analysi suggest children born high risk fertil behaviour suffer stunt aor ci underweight aor ci addit children born women multipl high risk categori higher odd stunt aor ci underweight aor ci compar children born women risk find highlight urgent need effect legisl prevent child marriag would help increas matern age birth govern also focus intervent health educ improv reproduct healthcar promot optim birth space
|
D013851;D006130
|
T033;T046
|
36,273,011
|
molecular structur dataset lignin macromolecul elucid experiment structur composit lignin one abund biopolym natur great potenti transform high valu chemic howev limit avail molecular structur data hinder potenti industri applic herein present lignin structur lgs dataset includ molecular structur mill wood lignin focus two major monomer unit coniferyl syringyl six common interunit linkag phenylpropan aryl ether resinol phenylcoumaran biphenyl dibenzodioxocin diaryl ether dataset constitut uniqu resourc cover part lignin chemic space character polym chain length rang monom unit structur data generat use sequenc control polym generat approach calibr match experiment lignin properti lgs dataset includ k newli generat lignin structur match high accuraci experiment determin structur composit avail literatur lgs dataset valuabl resourc advanc lignin chemistri research includ comput simul approach predict model
|
D008031;D014934
|
T123;T167;T109
|
36,273,010
|
comprehens ultra wideband dataset non cooper contextu sens nowaday increas amount attent devot toward passiv non intrus sens method prime exampl healthcar applic bodi sensor alway option applic requir detect track unauthor non cooper target within given environ therefor paper present dataset consist measur obtain radio frequenc rf devic essenti dataset consist ultra wideband uwb data form channel impuls respons cir acquir via commerci shelf cot uwb equip approxim hour annot measur provid collect residenti environ dataset use passiv track target locat indoor environ addit also use advanc uwb base human activ recognit har sinc three basic human activ record name sit stand walk anticip dataset may util develop novel algorithm methodolog healthcar smart home secur applic
|
D000465;D011846
|
T170;T070
|
36,273,009
|
systemat review effect e cigarett use lung function given increas use e cigarett uncertainti surround safeti conduct systemat review determin effect e cigarett measur lung function systemat search embas medlin psycinfo databas via ovid cochran central databas web scienc core juli identifi potenti elig studi total eight studi seven studi immedi effect one long term effect total particip includ risk bias assess use risk bias non random studi intervent robin cochran risk bias tool studi suggest vape increas airway resist appear impact forc expiratori volum one second fev forc vital capac fvc fev fvc ratio howev given limit size follow durat studi larger long term studi requir determin effect e cigarett lung function
|
D000072137;D066300
|
T055;T073
|
36,273,007
|
ectop express sericin enabl effici product ancient silk structur chang silkworm bombyx mori silk super long natur protein fiber uniqu structur excel perform innov silk structur high perform great demand thus result industri bottleneck herein outer layer sericin ser ectop express posterior silk gland psg silkworm via piggybac mediat transgen approach secret inner fibroin layer thus generat fiber sericin microsom dispers fibroin fibril water solubl ser protein secret psg caus p detach fibroin unit fib hfib lp polym accumul fibroin layer sericin layer consequ water solubl stabil fibroin colloid silk glandular caviti crystallin increas mechan properti cocoon fiber moistur absorpt moistur liber silk also improv meanwhil mutant overcom problem low surviv abnorm silk gland develop thus enabl higher product effici cocoon silk summari describ silk gland transgen target protein select strategi alter silk fiber structur innov properti work provid effici green method produc silk fiber new function
|
D012831;D047030;D005349
|
T123;T121;T116;T204
|
36,273,006
|
singl cell transcriptom analysi highlight origin patholog process human endometrioid endometri carcinoma endometri cancer complex ecosystem compos cell distinct phenotyp genotyp epigenet state current model adequ reflect oncogen origin patholog progress patient use singl cell rna sequenc profil cell normal endometrium atyp endometri hyperplasia endometrioid endometri cancer eec altogeth repres step step develop endometri cancer find eec origin endometri epitheli cell stromal cell uncili glandular epithelium sourc eec also identifi lcn saa cell featur subpopul endometri tumorigenesi final stromal nich immun environ chang eec progress describ studi elucid evolut cell popul eec develop singl cell resolut would provid direct facilit eec research diagnosi
|
D018269;D004714;D016889
|
T047;T191
|
36,273,003
|
protein languag model train multipl sequenc align learn phylogenet relationship self supervis neural languag model attent recent appli biolog sequenc data advanc structur function mutat effect predict protein languag model includ msa transform alphafold evoform take multipl sequenc align msas evolutionarili relat protein input simpl combin msa transform row attent led state art unsupervis structur contact predict demonstr similar simpl univers combin msa transform column attent strong correl ham distanc sequenc msas therefor msa base languag model encod detail phylogenet relationship show model separ coevolutionari signal encod function structur constraint phylogenet correl reflect histor conting assess generat synthet msas either without phylogeni pott model train natur msas find unsupervis contact predict substanti resili phylogenet nois use msa transform versus infer pott model
|
D007802;D011506
|
T123;T171;T116
|
36,272,995
|
presenc entri receptor viral marker suggest low level placent replic hepat b virus proport pregnant women infect chronic hepat b transplacent rout vertic transmiss hepat b virus hbv known decad present evid suggest hbv replic placenta forti one hbsag posit control pregnant women enrol studi obtain inform consent hbv posit divid high viral load hvl group low viral load lvl group accord inasl guidelin presenc hbv dna express ntcp placenta analyz qpcrrt qpcr andor immunohistochemistri ihc presenc cccdna assess use digit droplet pcr presenc pre genom pg rna assess qrt pcr sequenc presenc hbeag hbcag placenta assess ihc immunostain ntcp hbeag hbcag trophoblast along presenc total hbv dna cccdna pgrna indic cell suscept hbv infect may also support viral replic support find trophoblast sever hbeag seroneg sampl harbor hbeag although find correl ntcp express viral marker viral load indic placent replic may ape hepatocyt presenc hbv receptor ntcp along presenc cccdna pgrna hbeag placenta hbv infect femal without circul hbeag suggest placenta act replic host
|
D019694;D006509
|
T047
|
36,272,994
|
develop vivo cleavabl donor plasmid target transgen integr crispr cas crispr casa crispr cas system wide use genom edit cultur cell organ discoveri new singl rna guid endonucleas crispr casa addit convent crispr cas broaden number edit target site genom develop vivo cleavabl donor plasmid precis target knock extern dna cas casa plasmid name pcrimget plasmid synthet crispr code rna target sequenc equip donor plasmid mediat gene target via cas casa compris protospac adjac motif sequenc cas casa side target free synthet crispr code rna target sequenc multipl clone site donor cassett insert pcrimget generat linear donor cassett vivo crispr cas crispr casa result increas knock effici cultur cell method also achiev target knock long extern dna kb mice crispr cas crispr casa pcrimget system expand genom target space transgen knock provid versatil low cost high perform crispr genom edit tool
|
D064113;D000072669
|
T063;T040
|
36,272,992
|
moder effect prefront respons sleep relat stimuli associ depress sleep disturb insomnia disord investig differ brain activ respons sleep relat pictur chronic insomnia disord cid patient good sleeper gs examin whether brain activ moder relationship depress symptom sleep disturb cid patient gs studi includ patient diagnos cid base intern classif sleep disord gs particip kept sleep diari underw nocturn polysomnographi measur sleep paramet complet self report questionnair assess sleep psychiatr symptom underw function magnet reson imag fmri examin differ brain activ respons sleep relat pictur compar neutral pictur moder moder analysi perform investig moder role brain respons sleep relat pictur associ depress symptom sleep disturb compar gs brain respons sleep relat stimuli signific lower cid patient right later prefront cortex lpfc dorsomedi prefront cortex dmpfc sever depress symptom signific associ longer sleep latenc lpfc activ low cid patient gs lpfc hypoact respons sleep relat stimuli cid patient could moder relationship depress sleep disturb
|
D007319;D012893
|
T184;T047;T048
|
36,272,991
|
pseudogen associ cerna network potenti prognost biomark colorect cancer colorect cancer crc one common malign carcinoma mani long noncod rnas lncrnas report play import role tumorigenesi crc influenc express mrnas via compet endogen rna cerna network interact mirna pseudogen one kind lncrna act rna spong mirna regul gene express via cerna network howev studi pseudogen crc studi differenti express de pseudogen de mirna de mrnas identifi analyz express profil colon adenocarcinoma obtain cancer genom atlas cerna network construct base rnas kaplan meier analysi show pseudogen mirna mrnas signific associ overal surviv multivari cox regress analysi cerna relat de pseudogen perform pseudogen signatur greatest prognost valu crc identifi moreov result valid gene express omnibus databas quantit real time pcr pair crc tissu colon cancer cell line studi provid pseudogen associ cerna network prognost pseudogen biomark pseudogen prognost risk signatur may use predict surviv crc patient
|
D062085;D000230;D003110;D035683
|
T123;T191;T114
|
36,272,990
|
spontan variabl predict compens motor respons vocal pitch control motor system use sensori feedback keep desir perform view motor fluctuat simpli nois inevit caus nervous system would play role generat variat explor better outcom via sensori feedback vocal system offer good model studi sensori motor interact sinc regul vocal hear voic behavior typic observ compensatori respons vocal pitch fundament frequenc f artifici f shift induc auditori feedback howev relationship adapt regul motor explor vocal remain unclear investig behavior variabl spontan vocal f compensatori respons f shift feedback demonstr larger spontan fluctuat correl greater compens vocal f correl found slow compon hz spontan fluctuat fast compon hz slow one amplifi compensatori respons furthermor compensatori ratio reduc larg f shift appli auditori feedback reflect rang motor explor find consist suggest function role motor variabl explor better vocal outcom
|
D010898;D056228
|
T067;T041
|
36,272,988
|
visual consequ stimulus complex affect perform audiovisu associ learn associ learn al cue andor outcom event coupl togeth al typic test visual learn paradigm recent group develop various al test base rutger acquir equival test raet visual audiovisu keep structur logic raet differ stimuli studi volunt test two audiovisu test soundfac sf soundpolygon sp anteced stimuli test sound consequ stimuli imag consequ sf cartoon face sp simpl geometr shape aim test complex appli consequ stimuli influenc perform regard various aspect learn test assess stimulus pair learn retriev general previous learn associ new predict stimulus pair sp behavior perform signific poorer sf reaction time signific longer phase test result suggest audiovisu associ learn signific influenc complex consequ stimuli
|
D007858;D005793
|
T062;T041;T061
|
36,272,987
|
neural interact work memori explain decreas recal precis similar base featur repuls last sever year studi work memori wm simpl visual featur eg color orient domin perspect assum item wm store independ one anoth evid reveal howev systemat bias wm recal suggest item wm interact activ mainten present studi report two experi replic repuls bias metric similar color activ storag wm also observ metric similar color store lower resolut uniqu color held activ mind time account effect report quantit simul two novel neurodynam model wm model uniqu behavior signatur report emerg direct later inhibitori neural interact serv maintain multipl distinct neural represent throughout wm delay period simul result show full pattern empir find obtain model includ elabor spatial pathway sequenti encod memori display item discuss implic find theori visual work memori general
|
D008570;D000078382
|
T041
|
36,272,986
|
establish vivo proxim label biotin use turboid filament fungus sordaria macrospora proxim depend biotin identif bioid emerg power methodolog identifi protein co local given bait protein vivo approach establish anim cell plant yeast yet filament fungi bioid reli promiscu biotin ligas fuse bait protein coval label neighbor protein biotin biotinyl protein specif enrich biotin affin captur denatur cell lysat subsequ identifi quantifi liquid chromatographi mass spectrometri lc ms contrast mani affin captur approach studi protein protein interact bioid reli physic protein protein bind within nativ cell lysat featur allow identif protein proxim weak transient dynam natur demonstr applic bioid fungal model organ sordaria macrospora sm use exampl stripak complex interactor sci well character striatin interact phosphatas kinas smstripak complex proof concept establish bioid macrospora codon optim turboid biotin ligas fuse sci biotin captur known smstripak compon pro smmob pro smppac demonstr success bioid applic macrospora bioid proxim label approach provid power proteom tool fungal biologist
|
D001710;D005658
|
T121;T004;T127;T109
|
36,272,985
|
addit pinus massoniana fallen wood improv growth plagiomnium acutum substrat cultiv soilless cultur wide use horticultur plant product littl research done bryophyt studi select cultiv substrat mix proport garden soil granular soil grass charcoal soil general purpos nutrient soil decompos grade ii iii iv fallen wood pinus massoniana raw materi soilless substrat investig effect growth physiolog plagiomnium acutum result show total poros water hold poros water hold capac mix substrat contain fallen wood p massoniana signific higher cultiv substrat averag cover p acutum signific posit correl substrat total poros water hold poros chlorophyl content high signific posit correl water hold capac total nitrogen content substrat among v iii decomposit grade pinus massoniana fallen log v grass charcoal soil sw substrat highest overal evalu index best overal growth condit p acutum summari v iii decomposit grade pinus massoniana fallen log v grass charcoal soil sw substrat best substrat cultiv p acutum addit p massoniana fallen wood soil substrat increas total poros water hold poros water hold capac substrat conduc growth p acutum increas chlorophyl content
|
D028223;D019068
|
T002
|
36,272,984
|
feasibl optim cerebr perfus pressur valu identif without delay long optim cerebr perfus pressur cppopt target treatment traumat brain injuri tbi patient requir h multi modal monitor data accumul identifi cppopt valu individu patient minim time requir monitor data accumul need improv efficaci cppopt target therapi retrospect analysi multimod physiolog monitor data sever tbi patient perform separ repres cerebrovascular autoregul ca indic relat cpp arteri blood pressur abp intracrani pressur icp improv exist cppopt identif algorithm machin learn ml base algorithm develop automat identif inform data segment use reliabl cppopt abpopt icpopt lowerupp limit ca llcaulca identif refer dataset inform data segment artifact distort segment dataset differ clinic situat use train ml base algorithm allow us choos appropri individu cpp abp icp guid manag full monitor time studi popul develop ml base algorithm allow us recogn inform physiolog abpicp variat within min interv accuraci compar initi accuraci use segment time optim valu identif ca limit determin cpp abp icp data prospect clinic studi need prove effici develop algorithm
|
D007427;D000070642
|
T037;T042
|
36,272,982
|
communic skill children age year without cerebr palsi cool neonat hypox ischem encephalopathi assess communic skill children without cerebr palsi cp treat therapeut hypothermia th neonat hypox ischem encephalopathi hie case compar control earli school age examin associ white matter diffus properti group month bayley iii development assess case parent complet children communic checklist ccc yield general communic composit gcc structur pragmat languag score autist type behavior score gcc threshold structur pragmat languag score differ defin languag impair use tract base spatial statist tbss fraction anisotropi fa compar case control compar control case lower gcc p structur p pragmat languag score p higher languag impair p gcc correl fa mid bodi corpus callosum cingulum superior longitudin fasciculus p case bayley iii languag composit correl gcc r p structur r p pragmat r p languag score autist type behavior r p
|
D020925;D002547;D066127
|
T019;T047;T024;T023
|
36,272,981
|
effect differ milk feed level frequenc perform holstein heifer wean first lactat present studi effect milk feed amount feed frequenc ff perform blood metabolit rumen ferment perform dairi heifer first artifici insemin ai first lactat investig treatment group consist femal holstein heifer calv treatment distribut factori arrang milk feed high ld hl medium ld ml feed frequenc calv fed step upstep method wean milk age observ age heifer calv kept uniform age first lactat evalu long term effect treatment observ ff effect interact level ff feed intak averag daili gain adg feed effici fe bodi weight bw structur growth blood metabolit rumen ferment paramet calv fed hl milk higher total dri matter intak dmi bw adg pre post wean period prewean period hl fed calv higher serum insulin trend glucos concentr compar ml fed calv lower age first ai observ calv fed hl rather ml regardless ff weight first ai milk yield energi correct milk ecm first lactat show trend toward higher valu hl fed calv compar ml fed calv prewean perform calf matur posit affect feed high amount milk ff
|
D008892;D061385
|
T168;T121;T031
|
36,272,980
|
alarm antibiot resist helicobact pylori children southeast china year increas rate antibiot resist helicobact pylori h pylori major concern decreas erad rate larg scale long period studi antimicrobi suscept h pylori children limit studi aim describ tempor chang antibiot resist among children southeast china gastric biopsi obtain children cultur h pylori suscept clarithromycin cla amoxicillin aml metronidazol mtz furazolidon fzd tetracyclin tet levofloxacin lev test data report previous obtain compar chang tempor trend antibiot resist total h pylori strain isol children recruit resist rate cla mtz lev respect strain resist singl resist doubl resist tripl resist total resist rate resist rate cla mtz lev cla lev cla mtz lev increas annual linear manner resist pattern except singl resist increas obvious compar doubl resist cla mtz increas signific age resist rate cla tripl resist cla mtz lev increas children prior h pylori treatment children without prior treatment antibiot resist rate h pylori high larg pediatr popul southeast china individu treatment base suscept test imper optim regimen chosen h pylori erad therapi
|
D016480;D016481
|
T047;T007
|
36,272,978
|
molecular basi isoform select inhibit presenilin mrk inhibit secretas activ repres potenti therapeut strategi alzheim diseas ad mrk select inhibitor higher potenc presenilin ps ps two isoform catalyt subunit secretas although under mechan remain elus report cryo electron microscopi cryo em structur ps ps contain secretas complex without mrk overal resolut mrk occupi substrat bind site ps invis ps structur comparison identifi thr leu ps determin isoform depend sensit mrk confirm swap experi ps ps reveal mechan isoform select inhibit presenilin work may facilit futur drug discoveri target secretas
|
D053829
|
T126;T116
|
36,272,977
|
redd promot obes induc metabol dysfunct via atyp nf b activ regul develop dna damag respons redd express upregul respons metabol imbal obes howev role obes associ complic unclear demonstr redd nf b axi crucial metabol inflamm dysregul mice lack redd whole bodi adipocyt exhibit restrain diet induc obes inflamm insulin resist hepat steatosi myeloid redd defici mice show similar result without restrain obes hepat steatosi redd defici adipos deriv stem cell lost potenti differenti adipocyt howev redd overexpress stimul preadipocyt differenti proinflammatori cytokin express atyp ikk independ nf b activ sequest ib nf bib complex redd mutat lys ala key amino acid residu ib bind could stimul nf b activ adipogenesi inflamm vitro prevent obes relat phenotyp knock mice redd atyp nf b activ axi therapeut target obes meta inflamm metabol complic
|
D016328;D005234
|
T129;T047;T116
|
36,272,975
|
trpm contribut sex dimorph promot recoveri normal sensit mous model chronic migrain trpa trpm transient receptor potenti channel express trigemin neuron relat pathophysiolog migrain model use mous model nitroglycerin induc chronic migrain display sexual dimorph phenotyp character mechan hypersensit develop male femal persist day femal mice disappear day male mice trpa requir develop hypersensit male femal wherea trpm contribut faster recoveri hypersensit male trpm mediat antinocicept effect requir presenc endogen testosteron male administr exogen testosteron femal orchidectom male led recoveri hypersensit calcium imag electrophysiolog record vitro system confirm testosteron activ murin human trpm independ androgen receptor express find suggest protect function trpm shorten time frame hypersensit mous model migrain
|
D050053;D050051;D008881
|
T123;T047;T116
|
36,272,974
|
character somat structur variat chines individu esophag squamous cell carcinoma esophag squamous cell carcinoma escc demonstr high genom instabl analyz whole genom investig structur variat mechan biolog function svs show multi mode distribut size indic distinct mutat process develop tool defin five type complex rearrang templat insert highlight type fold back invers associ poor outcom distinct rearrang signatur demonstr variabl genom metric replic time spatial proxim chromatin access specif fold back invers tend occur near centrosom td c tandem duplic cluster signific enrich chromatin access earli replic region compar signatur analys td c signatur reveal td hotspot identifi hotspot consist super enhanc pthlh confirm oncogen effect pthlh gene interact enhanc function experi final extrachromosom circular dnas ecdna present escc strong select advantag driver gene
|
D000077277;D004938;D002294
|
T191
|
36,272,973
|
pd l direct plgfvegf blockad synerg chemotherapi target cd cancer associ fibroblast pancreat cancer pancreat ductal adenocarcinoma pdac poor year overal surviv rate patient pdac display limit benefit undergo chemotherapi immunotherapi modal herein reveal chemotherapi upregul placent growth factor plgf direct activ cancer associ fibroblast caf induc fibrosi associ collagen deposit pdac patient poor prognosi high pigfvegf express increas number pigfvegf receptor express caf associ enhanc collagen deposit also develop multi paratop vegf decoy receptor ate grab fuse singl chain fv atezolizumab anti pd l vegf grab target pd l express caf ate grab exert anti tumor anti fibrot effect pdac model via pd l direct plgfvegf blockad furthermor ate grab synerg gemcitabin reliev desmoplasia singl cell rna sequenc identifi cd caf popul reduc upon ate grab gemcitabin combin treatment overal result elucid mechan under chemotherapi induc fibrosi pdac highlight combinatori therapeut strategi desmoplast cancer
|
D000072645;D057127;D010190;D021441;D000970
|
T121;T129;T025;T109;T191
|
36,272,971
|
effect heat stress rdna metagenom metabolom holstein cow differ growth stage heat stress import issu dairi cattl feed manag affect summer health econom effici experi combin rdna sequenc tag sequenc data metagenom sequenc read sequenc data metabolom analysi sequenc data blood index analysi ten cow anim type grow heifer heifer lactat cow select sampl collect april august character chang metabolit rumen microbi communiti function potenti effect heat stress serum biochem immun oxid stress hormon indic deriv rumen fluid serum sampl cow differ growth stage differ climat generat data expand resourc rumen microbiom relat heat stress age provid use dataset research develop therapeut strategi achiev high summer milk product cow dataset help research studi effect heat stress physiolog metabol holstein cow time depend chang associ growth stage
|
D018869;D007774;D054892
|
T039;T040;T028;T042
|
36,272,970
|
transcriptom reprogram epstein barr virus infect epitheli b cell reveal distinct host virus interact profil epstein barr virus ebv opportunist pathogen manifest potenti contributor human diseas year primari infect specif lymphoid epitheli cell malign immun compet immun compromis host virus shuttl b cell epitheli cell infect cycl facilit persist transmiss human ebv effici infect transform b lymphocyt epitheli cell suscept transform vitro util platform cultur normal oral keratinocyt cell nok use matrigel greater insight molecular interact ebv infect cell determin transcriptom ebv infect nok peripher blood mononuclear cell pbmcs day lmps b ebna b c detect sampl lytic gene express signific higher nok pbmcs identifi cellular gene differenti express p valu gene ontolog go pathway analys signific identifi pathway relat collagen activ chemokin signal immun respons metabol antivir respons also identifi signific chang metalloproteas gene encod chemotact ligand cell surfac molecul c x c chemokin receptor type cxcr dramat downregul pbmcs upregul nok howev mmp signific downregul nok upregul pbmcs therefor multipl pathway contribut distinct patholog associ ebv infect epitheli b cell mmp cxcr critic molecul involv regul latent lytic state link viral associ diseas
|
D004854;D020031
|
T005;T047
|
36,272,875
|
intracellular autolyt whole cell salmonella vaccin prevent colon pathogen salmonella typhimurium chicken salmonella enterica se major foodborn bacteri pathogen unit state common found normal flora various anim attribut caus least million infect annual poultri play major role dissemin se direct contact live anim consumpt contamin product vaccin poultri se sustain approach reduc se host prevent futur infect human intracellular autolyt se serovar typhimurium vaccin stlt p develop integr gene holin lysozym bacteriophag p bacteri chromosom insert downstream ssea spi chaperon se express intracellular phase se intracellular viabil stlt p reduc hr compar wild type chicken macrophag cell hd wherea growth rate adhes abil remain unchang inocul stlt p hd signific enhanc relat log fold express gene associ product pro inflammatori cytokin il il il il il p il gm csf toll like receptor trl vaccin vivo chicken model demonstr signific chang secret ino il il il tnf well reduct intestin colon se serovar typhimurium microbiom analysi cecal fluid use rrna gene sequenc also show modul intestin microbi composit specif decreas relat abund proteobacteria increas firmicut studi provid insight novel vaccin design could make food product safer without use synthet compound
|
D012481;D019779;D022562;D011201
|
T121;T129;T047;T007
|
36,272,865
|
ancient tree irreplac conserv resourc ecosystem restor ancient tree contribut multifacet ecosystem benefit old growth forest rewild human cultur landscap call intern effort preserv hub divers resili global coalit util advanc technolog communiti scientist discov protect propag ancient tree need disappear
|
D017753;D014197
|
T070;T002;T082
|
36,272,811
|
singl chain condens state behavior hnrnpa molecular simul intrins disord protein idp essenti compon format membraneless organell play key function regulatori role within biolog system complex assembl form dissolv spontan time via liquid liquid phase separ idp mutat amino acid sequenc alter phase behavior link emerg sever diseas studi conform phase behavior low complex domain heterogen nuclear ribonucleoprotein hnrnpa use coars grain implicit solvent molecular dynam simul systemat analyz properti affect number aromat residu within examin sequenc find signific compact chain increas critic temperatur increas number aromat residu local persist length determin singl chain simul reveal strong sequenc specif variat along chain contour compar singl chain condens state simul find mani collaps polym conform dilut system even temperatur near estim temperatur solut observ strong support hypothesi aromat residu play domin role condens corrobor detail analysi intermolecular contact convers import properti condens captur coars grain simul interest observ densiti inhomogen within condens near critic driven electrostat interact final find relat small fraction hydrophob residu idp result interfaci tension signific lower compar typic combin immisc simpl liquid
|
D064267;D001669
|
T123;T070;T116;T044
|
36,272,802
|
guid self assembl colloid diamond assembl colloid cubic diamond challeng process sinc shape interact paramet thermodynam condit structur stabl elus simultan use shape anisotrop particl strong direct interact proven success path exclus nucleat structur use molecular dynam simul explor detail condit nucleat cubic diamond tetrahedr build block favor particular focus effect deplet dna mediat interact form stabil cubic diamond crystal find particular balanc strength rang deplet interact enhanc self assembl stabl cubic diamond lead narrow region structur nucleat moreov determin stronger short rang deplet attract may arrest system lead format percol diamond network fulli disord gel structur accord intern arrang structur exhibit distinct variat term fractal dimens presenc six member ring increas acquir intern strain arrest get pronounc result provid clear rout self assembl cubic colloid diamond toward realize crystal superior photon properti
|
D003102;D018130
|
T122;T196
|
36,272,801
|
solid state synthesi uv plasmon cr n nanoparticl materi exhibit plasmon respons uv region advantag mani applic biolog photodegrad photocatalysi disinfect bioimag transit metal nitrid recent emerg chemic thermal stabl altern metal base plasmon materi howev free stand nitrid nanostructur explor far plasmon respons visibl near ir region herein report synthesi uv plasmon cr n nanoparticl use solid state nitrid reaction nanoparticl averag diamet nm posit charg surfac yield stabl colloid suspens particl compos crystallin nitrid core amorph oxideoxynitrid shell whose thick vari nm calcul perform use finit element method predict local surfac plasmon reson lspr nanoparticl uv c region nm distinct lspr peak could observ use absorb measur low loss electron energi loss spectroscopi show presenc surfac plasmon nm ev bulk plasmon center around nm ev plasmon coupl also observ nanoparticl result reson nm ev
|
D049329;D053758
|
T073
|
36,272,800
|
phase equilibria molecular simul hydrogen hydrat via direct phase coexist approach report three phase hydrat liquid water vapor equilibrium condit hydrogen water binari system calcul molecular dynam simul via direct phase coexist approach signific improv k obtain current studi earlier simul attempt use combin modif relat hydrogen model includ hydrogen lennard jone paramet function temperatur ii water guest energi interact paramet optim use lorentz berthelot combin rule base improv descript solubl hydrogen water
|
D006859;D014867
|
T121;T196;T197
|
36,272,795
|
coupl local mode method simul vibrat spectroscopi experiment theoret studi highlight proton water cluster pwcs import model excess proton aqueous system signific focus character spectral signatur associ differ excess proton solvat motif accur vibrat frequenc calcul crucial connect measur spectra structur pwcs paper extend character coupl local mode clm approach calcul infrar spectra pwcs use h h cluster benchmark system clm method relat low cost incorpor anharmon coupl oh vibrat demonstr accuraci techniqu compar experi also illustr depend calcul spectral featur under electron structur theori basi set use local mode frequenc coupl calcul
|
D014732;D011522
|
T196;T070
|
36,272,793
|
semiflex polym solut ii fluctuat frank elast constant studi collect elast behavior semiflex polym solut nemat liquid crystallin state use polym field theori polym field theoret model semiflex polym solut extend includ second order fluctuat correct free energi permit evalu frank elast constant base orient order fluctuat nemat state exact treatment wormlik chain statist permit evalu behavior nemat state thus accur captur impact singl chain behavior collect elast respons result frank elast constant present function align field strength chain length explor impact conform fluctuat hairpin defect twist splay bend moduli result indic twist elast constant k twist smaller bend splay constant k bend k splay respect entir rang polym rigid splay bend elast constant exhibit regim domin rang chain stiff k splay k bend flexibl polym larg n limit opposit true rigid polym theoret analysi also suggest splay modulus track exact end end distanc transvers direct semiflex polym intermedi larg n result provid insight role conform fluctuat hairpin defect collect respons polym solut
|
D008956;D011108
|
T104;T122;T170
|
36,272,789
|
dival cation induc entrant condens behavior lipopolysaccharid lipopolysaccharid lpss negat charg molecul cover surfac gram negat bacteria gnb ad dival cation dcs import stabil lps bilay thus dcs alway consid membran stabil ion basi coars grain cg martini forc field conduct molecular dynam md simul studi dival cation mediat lps interact stabil lps membran wide rang dc concentr measur lps bind free energi lps lps aggreg associ cours two lps molecul find initi addit dcs may signific facilit aggreg lpss compact structur sequenti ad dcs unpack lps aggreg drive dissolut lpss increas concentr dcs find gradual replac dcs monoval cation condens counterion lps follow sign chang negat posit term lps effect charg switch lpss solut undergo precipit resolubil ad dcs interact chang level two lpss account structur variat lps assembl larger scale lps pack rigid assembl bilay found similar nonmonoton depend dc concentr thus result demonstr first time presenc entrant condens behavior lps molecul exploit develop novel membran perturb agent base multival ion effici gnb antibiot
|
D008070;D006090
|
T007;T109
|
36,272,788
|
layer capillari wave structur factor liquid surfac within extend capillari wave theori ecwt extract bend modulus liquid surfac total structur factor interfaci region requir separ capillari wave cw signal non cw background year ago hfling dietrich hd work strict graze incid limit q z propos background combin liquid vapor bulk structur factor amount set gibb plane contrast propos molecular dynam md simul lennard jone model analyz intrins sampl method ism studi extend q z test stronger consist requir ecwt experiment condit show good md ecwt match although need fine tune hd propos agreement ism result surfac bend modulus good provid interpret term molecular layer liquid edg fluctuat surfac repres cw signal surfac structur factor md simul surfac diffract experi
|
D008956;D056004
|
T066;T170;T044
|
36,272,778
|
origin diffus share proton vibrat signatur proton coupl electron transfer model dyad complex phenol benzimidazol phenol pyridin dyad complex serv popular model system studi proton coupl electron transfer pcet kinet solut phase experi interpret measur pcet rate term key structur paramet h bond donor acceptor distanc howev remain challeng herein report vibrat spectra electron ground state seri phenol benzimidazol phenol pyridin complex isol cryogen cool ion trap four model studi display high red shift broaden oh stretch transit aris strong h bond interact phenol oh group basic n site benzimidazolepyridin ring oh stretch transit model display relat strong absorpt onset near cm broad shoulder extend asymmetr higher frequenc hundr wavenumb contrast deuter isotopologu yield much weaker od stretch transit appear symmetr broaden spectral breadth shape od stretch transit ascrib variat od stretch frequenc aris zero point distribut proton donor acceptor low frequenc soft mode vibrat asymmetr structur oh stretch transit attribut set combin band oh stretch seri low frequenc h bond soft mode spectra model highlight import oh stretch soft mode coupl thought play import role pcet proton transfer dynam
|
D011522;D014732
|
T196;T070
|
36,272,777
|
reduct pathway glutaredoxin investig qmmm molecular dynam use neural network correct glutaredoxin small enzym catalyz oxid reduct protein disulfid bond thiol disulfid exchang mechan either one two cystein activ site result differ catalyt reaction cycl investig mani experiment studi howev exact mechan yet fulli known knowledg theoret studi perform elucid under mechan studi investig propos mechan reduct disulfid bond protein hman mutat monothiol homo sapien glutaredoxin co substrat glutathion catalyt cycl involv three success thiol disulfid exchang occur molecul estim regioselect differ attack classic molecular dynam simul perform trajectori analyz regard sulfur sulfur distanc attack angl sulfur free energi profil reaction obtain hybrid quantum mechanicalmolecular mechan metadynam simul sinc requir extens phase space sampl semi empir densiti function tight bind method use describ reactiv cystein accur descript use specif reaction paramet fit blyp energi thiol disulfid exchang machin learn energi correct train coupl cluster singl doubl perturb tripl ccsd energi thiol disulfid exchang calcul show regiospecif observ experi obtain barrier height kcalmol differ reaction step confirm propos pathway
|
D054477;D056004
|
T066;T126;T116;T044
|
36,272,761
|
trend us depress preval widen treatment gap major depress common potenti lethal condit earli data suggest popul level burden depress exacerb covid pandem prepandem estim depress preval requir quantifi comprehens address pandem impact mental health us
|
D003865;D000086382
|
T047;T067;T048
|
36,272,760
|
social engag caus mortal focus particip minor age research studi social engag known improv health less known whether social activ core african american life decreas mortal risk minorit popul studi investig whether aspect social engag predict mortal risk older african american
|
D058992;D000089323
|
T091;T054
|
36,272,759
|
us state preemption law work age mortal goal studi estim state preemption law prohibit local author rais minimum wage mandat paid sick leav contribut work age mortal suicid homicid drug overdos alcohol poison transport accid
|
D006708;D013405
|
T033;T055;T068;T054
|
36,272,758
|
intersect sexual orient race ethnic associ e cigarett use status among us youth although structur discrimin sexual racialethn minor putat risk factor youth tobacco use understand health dispar youth e cigarett use intersect sexual orient race ethnic still lack studi aim examin differ e cigarett use preval among us youth intersect sexual orient race ethnic
|
D066300;D000072137;D000072339
|
T055;T098;T073
|
36,272,755
|
execut summari kdigo clinic practic guidelin diabet manag chronic kidney diseas updat base rapid emerg new evid kidney diseas improv global outcom kdigo clinic practic guidelin diabet manag chronic kidney diseas ckd repres focus updat kdigo guidelin topic guidelin target broad audienc clinician treat peopl diabet ckd topic area recommend updat base new evid includ chapter comprehens care patient diabet ckd chapter glucos lower therapi patient type diabet td ckd content previous chapter glycem monitor target patient diabet ckd chapter lifestyl intervent patient diabet ckd chapter approach manag patient diabet ckd chapter deem current chang guidelin updat develop accord explicit process evid review apprais treatment approach guidelin recommend base systemat review relev studi apprais qualiti evid strength recommend follow grade recommend assess develop evalu grade approach limit evid discuss area addit research need present
|
D003924;D051436
|
T047
|
36,272,754
|
zone podocyt podocyt undergo defin morpholog chang develop homeostasi age injuri quantit podometr assess podocyt endow provid power tool interrog glomerular health expand approach region assess demonstr podocyt cortic subcort juxtamedullari glomeruli morpholog heterogen per se respond differ stressor age hypertens suggest zonal glomerular chang harbor critic inform understand glomerulopathi
|
D050199;D007674;D006973
|
T047;T025
|
36,272,753
|
endothelium endothelin regul arteri stiff fibrinolysi anca associ vascul issu farrah et al report clinic investig patient antineutrophil cytoplasm antibodi associ vascul aav demonstr endothelium depend vasodilat fibrinolyt capac monocyt depend endothelin clearanc reduc patient aav wherea circul level endothelin vascular stiff increas acut infus endothelin et receptor antagonist reduc vasoconstrict arteri stiff commentari discuss biolog insight clinic implic studi
|
D059289;D056648
|
T047;T046
|
36,272,752
|
antioxid nanozym prevent diseas kidney failur oxid stress state excess free radic common found diseas kidney therefor develop antioxid base therapi great interest biomed scientist kidney diseas manag one drawback use natur antioxid low bioavail limit anti free radic efficaci commentari discuss novel antioxid gold platinum nanoparticl potenti prevent kidney failur patient diagnos chronic kidney diseas
|
D000975;D053768
|
T123;T121;T073;T039;T044
|
36,272,751
|
polyploid tubular cell chronic kidney diseas defect dna repair drive chronic kidney diseas ckd mechan unclear airik colleagu use genet model defect dna repair mimick karyomegal nephriti form ckd character tubular epitheli cell tec larg nuclei tubulointerstiti nephriti show dna damag tec trigger endorepl lead polyploid tec ckd block endorepl preserv kidney function suggest dna damag trigger ckd via tec polyploid question concept gm arrest
|
D009395;D051436;D009393
|
T047
|
36,272,750
|
chlorid sensit signal turn potassium switch potassium switch refer plasma potassium regul sodium chlorid cotransport ncc control distal sodium deliveri therefor potassium secret low extracellular potassium activ ncc reliev chlorid inhibit lysin wnk new mous model carri chlorid insensit wnk mutant still show ncc activ low potassium diet effect mediat wnk activ kelch like klhl inhibit reveal addit chlorid sensit pathway ncc activ
|
D011188;D002712
|
T123;T196;T121;T034
|
36,272,739
|
estim epidemiolog dementia associ neuropsychiatr symptom appli machin learn real world data incid rate dementia relat neuropsychiatr symptom nps known hamper assess popul burden object studi obtain approxim estim popul incid preval dementia nps
|
D003704;D011618
|
T048
|
36,272,737
|
academi nutrit dietet revis standard practic standard profession perform regist dietitian nutritionist compet profici expert pediatr nutrit pediatr span first decad life dynam period rapid chang size physic abil cognit develop behavior nutrient need regist dietitian nutritionist rdns work pediatr popul provid nutrit knowledg support need promot optim health nutrit time across varieti set pediatr nutrit practic group along academi nutrit dietet qualiti manag committe updat standard practic sop standard profession perform sopp rdns work pediatr popul sop sopp rdns pediatr nutrit provid indic describ level practic compet profici expert sop use nutrit care process clinic workflow element deliv patientcli care sopp describ domain focus profession perform specif indic outlin sop sopp illustr standard appli practic sop sopp intend use self evalu tool assur compet practic pediatr nutrit determin potenti educ train need advanc higher practic level varieti set
|
D064686;D004046;D044623
|
T061;T058;T091;T097
|
36,272,732
|
investig use multiplex pcr childhood diarrhea clinic epidemiolog featur acut gastroenter one common caus hospit admiss children treatment regimen differ depend pathogen studi aim evalu epidemiolog clinic featur pediatr patient whose gastrointestin agent detect multiplex pcr
|
D060885;D005759
|
T063;T047
|
36,272,682
|
granular activ carbon exogen hydrogen enhanc anaerob digest hypersalin phenol wastewat via syntroph acet oxid hydrogenotroph methanogenesi high salin phenol wastewat inhibit anaerob metabol activ therebi affect anaerob biotransform phenol studi granular activ carbon gac coupl exogen hydrogen h use enhanc anaerob digest phenol gach group accumul methan product coenzym f concentr interspeci electron transfer system activ increas respect compar control group floc sludg gach group relat abund syntroph acet oxid bacteria syntrophus syntrophorhabdus genus level respect around time controlgroup moreov acinetobact methanobacterium methanosarcina signific enrich gac surfac gach group therefor coupl gac h provid novel attempt anaerob digest hypersalin phenol wastewat via syntroph acet oxid hydrogenotroph methanogenesi pathway
|
D002606;D062065
|
T121;T109;T196;T083;T069
|
36,272,680
|
nitrif resist function redund maintain system stabil partial nitrif high strength ammonium wastewat system sudden chang ammonia load high strength ammonium wastewat treatment direct affect system stabil alter microbi communiti dynam maintain system stabil effect ammonia shock load microbi communiti dynam must studi two set sequenc batch reactor oper shock cycl maximum volumetr load rate mg n ld cn system contain organ carbon ammonia n system contain ammonia compar n system cn system oper stabli higher nitrit accumul rate free ammonia fa select stress turnov cn microbi communiti n communiti shift much increas nitrosomona appear heterotroph nitrif aerob denitrif bacteria cn system present resist redund fa impact increas function gene exhibit function gene redund maintain system stabil
|
D058465;D064751
|
T104;T197;T044;T038
|
36,272,679
|
transit roadmap thermophil carbon dioxid microbi electrosynthesi test real exhaust gase oper control scalabl design human activ releas carbon dioxid co atmospher natur process remov studi attempt address main challeng thermophil c bioelectrochem convers co acet first real gaseous emiss test mix microbi consortia substanti influenc product rate differ subsequ bench scale system trl design launch control key oper variabl fix current co reduc rate kg co kg acet electr consumpt kwh kg effici valu far result suggest oper real effluent feasibl propos design energi effici right balanc maximis current densiti without compromis biocompat catalyst determin transit laboratori scale toward implement market
|
D002245;D005740
|
T123;T197;T104
|
36,272,678
|
nitrogen remov character function enzym identif hypothermia bacterium pseudomona fragi eh h novel hypotherm strain pseudomona fragi eh h found effect perform heterotroph nitrif aerob denitrif c strain could consum ammonium mgl nitrat mgl nitrit mgl accompani peak remov rate mglh respect ammonium remov preferenti simultan nitrif denitrif notabl elimin rate toxic nitrit nitrogen remain approxim mglh whether supplement ammonium stepwis inhibit experi reveal key enzym ammonia monooxygenas amo nitrit oxidoreductas nir nitrif denitrif coexist strain eh h amo nitrat reductas nir success express detect umg protein respect overal strain eh h outstand abil remov nitrogen low temperatur could provid guidanc cryogen wastewat treatment
|
D044206;D007035;D064751
|
T007;T104;T197;T033;T037
|
36,272,676
|
tdcs augment decis make effici intens depend manner train studi applic transcrani direct current stimul tdcs prefront cortex potenti improv perform cognit train alon stimul induc perform enhanc general beyond train task lead benefit untrain tasksprocess shown evid stimul intens non linear effect augment cognit train outcom howev current unclear stimul intens augment cognit process impact train transfer effect appli decis make model via linear ballist accumul framework understand aspect cognit process under speed singl dual task decis make perform chang tdcs intens one hundr twenti three particip split four group sham stimul intens particip complet four train session whilst tdcs deliv amp intens provid greatest benefit perform increas decis make effici measur drift rate train task sham stimul latent decis compon integr accuraci reaction time estim perform broad see invert u shape function stimul intens cognit perform train task either stimul much stimul sub optim perform contrast intens led increas drift rate untrain transfer singl task sum tdcs intens non linear modul cognit process relat decis make effici
|
D065908
|
T061
|
36,272,666
|
chronic agmatin treatment prevent olanzapin induc obes metabol dysregul femal rat antipsychot induc obes affect million peopl serious health condit worldwid olanzapin wide prescrib antipsychot agent high obesogen potenti howev exact mechan caus metabol dysregul remain poor understood studi investig effect agmatin olanzapin induc metabol derang femal spragu dawley rat repeat olanzapin administr day increas bodi weight treatment agmatin day prevent bodi weight gain induc olanzapin without alter food intak repeat agmatin treatment decreas elev feed effici adipos index well improv dysregul lipid metabol induc olanzapin increas activ fatti acid synthas fas decreas express carnitin palmitoyl transferas cpt detect chronic olanzapin treat rat although agmatin treatment alter fas activ increas cpt activ possibl inhibitori effect agmatin weight gain adipos might associ increas mitochondri fatti acid oxid energi expenditur olanzapin treat rat suggest agmatin explor prevent obes complic associ chronic antipsychot treatment
|
D014150;D000376
|
T121;T039;T123;T109
|
36,272,641
|
investig role central melanocortin system stress stress relat disord melanocortinerg neural circuit known influenc energi expenditur feed behavior also play role stress stress induc psychiatr disord includ anxieti depress major contribut given melanocortin receptor mcr subtyp high express brain region involv control stress respons furthermor mcr appear profound affect activ hypothalam pituitari adren hpa axi also highlight function anatom interact corticotropin releas factor crf import mediat stress stress relat behavior mcr agonist seem exacerb stress induc anxieti depress like behavior mcr antagonist demonstr mitig disord shown sever preclin behavior test evid collect present review suggest melanocortin system mcr could possibl modul behavior respons stress suggest use mcr antagonist possibl novel treatment anxieti depress induc stress
|
D053486;D010913
|
T125;T022;T116
|
36,272,640
|
effect microbiom modul probiot prebiot synbiot glucos homeostasi type diabet systemat review meta analysi meta regress clinic trial global escal diabet epidem respons signific morbid mortal microbiom modul nutraceut investig potenti restor metabol floral homeostasi type diabet patient method systemat review meta analys meta regress conduct investig effect probiot prebiot synbiot various biomark glucos homeostasi base multi databas search clinic trial publish april data pool use random effect meta analys report mean differ confid interv cis follow univari linear model meta regress
|
D003924;D064307;D019936;D058616
|
T032;T007;T168;T028;T047;T001
|
36,272,638
|
potenti effect alliacea brassicacea edibl plant blood glucos level patient type diabet systemat review meta analysi clinic trial type diabet td one main lead caus mortal worldwid global preval increas within next year mani pre clinic studi demonstr potenti effect edibl plant alliacea brassicacea regul blood glucos level note secondari metabolit alliacea brassicacea share abil slowli releas hydrogen sulfid hs emerg crucial modul glucos insulin system howev result clinic studi evalu effect edibl plant glycaem control patient td quit conflict perform systemat review meta analysi control clinic trial parallel cross search four databas pubm embas scopus cochran librari english written paper evalu effect alliacea brassicacea glycaem paramet diabet patient includ studi met inclus criteria includ random effect meta analysi consumpt alliacea brassicacea signific reduc fast blood glucos fbg level compar placebo group mean reduct mgdl confid interv ci moreov alliacea brassicacea signific improv effect standard antidiabet therapi mean reduct fbg level patient receiv combin therapi compar patient receiv standard antidiabet therapi mgdl overal regular consumpt edibl plant safe well toler suggest edibl plant contain organosulfur compound endow promis nutraceut potenti treatment td
|
D003924;D000490;D019607
|
T047;T002
|
36,272,637
|
morpho function analysi earli chang induc retin ganglion cell onset diabet retinopathi effect neuroprotect strategi retin ganglion cell rgcs high suscept diabet induc metabol stress studi describ earli respons rgcs hyperglycemia examin effect neuroprotect somatostatin analog octreotid oct
|
D003930;D003921;D006943
|
T033;T047;T050
|
36,272,632
|
development toxic assess tbbpa common use analog human embryon stem cell liver differenti model tetrabromobisphenol tbbpa wide use industri product halogen flame retard hfr substitut deriv also common employ hfrs consequ frequent detect environment human sampl potenti development toxic tbbpa analog particular human liver still controversi thorough assess therefor studi focus earli stage human liver develop explor toxic effect hfrs use human embryon stem cell liver differenti model conclud nanomolar treatment nm pollut may exert signific interfer liver develop function howev dose tbbpa analog sever affect liver function glycogen storag caus lipid accumul furthermor tbbpa bis allyl ether show drastic effect among six compound test taken togeth find support view tbbpa use safe provid amount strict control nonetheless tbbpa altern deriv may exhibit stronger advers effect tbbpa may safer choic manufactur applic util larg unrestrict way
|
D000066449;D006480;D011075;D005411
|
T120;T025;T109;T131;T047
|
36,272,630
|
anti estrogen activ impact complex environment matric dom multiphas distribut approach presenc estrogen endocrin disruptor aquat environ concern bioassay recommend tool monitor howev physicochem properti contamin environment matrix featur may influenc result respons studi aim assess influenc yeast estrogen screen yes assay mixtur estradiol e humic acid ha evalu schild approach aim investig interact estrogen dissolv organ matter dom moreov environment sampl municip landfil leachat wastewat treatment plant wwtp influent effluent screen anti estrogen activ dissolv particul phase final result statist confront physicochem paramet princip compon analysi pca ha test concentr strong reduc e respons even low level humic substanc may reduc estrogen bioavail also interfer assay mechan enzymat inhibit thus mask sampl estrogen potenti landfil leachat total e eq rang ng l wwtp influent effluent rang dl ng l estrogen reduc averag particul phase respons measur e eq matric though cytotox occur extract antiestrogen activ observ phase might also mask estrogen sampl pca result posit correl support multiphas distribut pattern estrogen compound nevertheless solid organ matter characterist support data interpret conclus vitro yes assay subject factor intrins environment sampl influenc measur estrogen respons therefor result interpret perform togeth organ matter character paramet cytotox antiestrogen activ evalu
|
D014874;D052244
|
T131;T039
|
36,272,629
|
foam fraction per polyfluoroalkyl substanc pfass landfil leachat use differ cosurfact foam fraction one solut recov per polyfluoroalkyl substanc pfass aqueous sourc separ process base sorption pfass air water interfac bubbl mani practic case pfas concentr pollut liquid low sustain foam format requir support cosurfact act collector pfas also produc sustain foam effect separ howev lack inform regard appropri choic cosurfact quantit effect interfaci partit pfass air bubbl studi direct evalu effect four cosurfact differ charg headgroup ie anion cation zwitterion nonion foam fraction pfass ii estim air water interfaci partit k pfass presenc four differ type cosurfact k valu span order magnitud good correl pfass molar volum cosurfact effect remov long chain pfass log cation zwitterion surfact opposit charg head group respect anion pfass therefor facilit increas separ due charg interact short chain pfass eg perfluorobutanesulfon acid pfbs perfluoropentanesulfon acid pfpes effect remov use cation zwitterion cosurfact
|
D014874;D005466
|
T131;T109
|
36,272,621
|
construct tunabl coordin unsatur site fe base metal organ framework effect degrad pharmaceut water perform mechan micropollut ubiquit detect aqueous environ need remov novel materi effect herein synthes photo fenton catalyst base mil fe effect degrad sulfadimidin one micropollut water abund lewi acid activ site molg success construct within metal cluster use fecl h benzen dicarboxyl modul studi report strategi effect construct tunabl lewi acid activ site within caviti mil fe via facil solvotherm reaction sixteen micropollut remov photo fenton degrad sulfamethazin complet remov within min small amount hydrogen peroxid ad theoret calcul experi result prove introduc unsatur coordinatedlewi acid site remark reduc band gap energi increas charg separ effici chang electron configur distribut asymmetri structur effect degrad structur divers pharmaceut environment relev concentr studi immobil mof catalyst pvdf support work advanc develop effect approach emerg contamin control
|
D000073396;D014874
|
T131;T109
|
36,272,620
|
risk assess microbi communiti structur agricultur soil contamin vanadium stone coal mine high health risk vanadium v releas mine vanadium titanomagnetit vtm wide recogn littl known risk microbi communiti respons v pollut consequ stone coal mine scm anoth import resourc v mine studi topsoil profil soil collect agricultur soil around typic scm hunan provinc china investig ecolog health risk microbi communiti structur result show sampl site level total v exceed chines nation standard ie mgkg v speciat topsoil pentaval vanadium v v meanwhil proport hq topsoil respect indic v might pose non carcinogen risk children addit microbi communiti vari topsoil profil soil sulfur oxid bacteria eg thiobacillus mnd ignavibacterium sulfat reduc bacteria eg desulfatiglan goutb gouta might involv v v reduct detoxif studi help better understand pollut associ risk v soil scm provid potenti strategi bioremedi v contamin environ
|
D012989;D003032;D064307
|
T090;T032;T131;T028;T001
|
36,272,613
|
evid coupl autotrophi heterotrophi plastic biofilm influenc surround seawat measur phytoplankton primari product heterotroph bacteri activ microplast seawat northwestern mediterranean sea two month spring period consecut year microorgan grow mm diamet low densiti polyethylen film ldpe thick face two contrast condit depend year spring character consist nutrient input bloom develop spring nutrient input bloom low first time observ clear coupl primari product heterotroph prokaryot product microplast year differ intens year reflect crucial role trophic environment condit nutrient suppli shape microbi activ plastic found high primari product plastic could support whole net autotrophi major bacteri carbon demand need heterotroph activ supplement carbon sourc surround water high product propos microbi activ plastic influenc microbi communiti surround seawat especi environment condit less favor illustr imag role plastic environ could invert electr circuit mitig posit negat variat result highlight potenti role plastispher shape biogeochem cycl context increas amount plastic particl marin environ
|
D010969;D000080545
|
T122;T167
|
36,272,612
|
co exposur pm high fat diet induc lipid metabol reprogram vascular remodel fine particul matter pm exposur prove increas cardiovascular diseas risk howev lack comprehens knowledg whether high fat diet hfd affect pm induc cardiovascular diseas purpos studi investig impair lipid metabol vascular function pm hfd exposur apo mice oil red stain indic co treatment pm hfd result mark lipid deposit mice aorta blood biochem analysi demonstr co exposur pm hfd could caus dyslipidemia vivo vascular doppler ultrasound histopatholog analysi found function structur alter fibrosi calcifi remodel vessel detect pm hfd exposur depth studi genom wide transcript analysi perform macrophag reveal endoplasm reticulum stress immun system process regul cell prolifer etc respons pm exposur lipid atherosclerosi signal pathway critic role pm induc vascular injuri result valid experi manifest releas supernat pm ox ldl treat macrophag could decreas cell viabil increas lipid ros vascular smooth muscl cell vsmcs moreov regul ccl il il aortic arch mice observ co exposur pm hfd data hint pm could affect lipid metabol reprogram induc vascular remodel accompani synergist effect hfd
|
D059305;D002318
|
T061;T047
|
36,272,610
|
superior dimethyl disulfid degrad microbi fuel cell extracellular electron transfer hybrid metabol pathway enhanc biolog degrad volatil organ sulfur compound microbi fuel cell mfc system superior activ develop dimethyl disulfid dmds degrad mfc achiev remov effici near within h initi concentr mg l maximum biodegrad rate constant mm h dmds remov load attain mmol h l time load convent biodegrad process report meanwhil maximum power densiti output correspond current densiti output w respect main mechan extracellular electron transfer classifi mediat electron transfer supplement direct transfer furthermor mass balanc analysi indic methanethiol hcho co main intermedi end product involv hybrid metabol pathway dmds overal find may offer basic inform bioelectrochem degrad dmds facilit applic mfc wast gas treatment environment implic dimethyl disulfid dmds featur poor solubl odor smell refractori properti typic pollut emit petrochem industri first time develop mfc system dmds degrad superior dmds remov load per unit reactor volum time convent biodegrad process literatur electron transfer rout hybrid metabol pathway dmds clear work overal find give depth understand bioelectrochem dmds degrad mechan provid effici altern dmds remov
|
D001674
|
T074;T073
|
36,272,609
|
character regul microplast pollut protect planetari human health microplast plastic particl mm diamet sinc exponenti increas product plastic estim approxim million metric ton plastic wast generat accumul landfil natur environ estim current trend continu rough million metric ton plastic wast accumul plastic microplast found ubiquit air water soil microplast small enough enter tissu plant anim detect human lung stool placenta blood presenc human tissu food chain caus concern direct clinic evid epidemiolog studi advers effect microplast human health lack vitro cellular tissu studi vivo anim studi suggest potenti advers effect ever increas presenc plastic wast environ critic understand effect environ human health use plastic addit mani known toxic effect also concern review provid brief overview microplast extent microplast problem inroad regul plastic current insuffici adequ mitig plastic pollut also review recent advanc microplast test methodolog support manag regul plastic wast signific effort reduc reus recycl plastic need individu communiti nation intern level meet challeng particular signific reduct plastic product must occur curb impact plastic human worldwid health given fact plastic truli recycl
|
D000080545;D014874
|
T131;T122
|
36,272,607
|
effect point sourc phosphorus arsenic mobil transport small fluvial system one lead caus releas streamb sediment freshwat system competit phosphat among import sourc p fluvial ecosystem wastewat treatment plant wwtp estim account p surfac water paper long term effect discharg phosphorus small wwtp arsenic mobil studi enrich fluvial system approx mgkg central czech republ year elev p mgl stream water total decreas total p increas sediment downstream distanc result chemic extract mineralog analys indic chang concentr most due sorption process fe oxyhydr oxid goethit hematit downstream sampl phase decreas two fold p signific enrich phosphorus also found precipit newli form ca phosphat stream water monitor indic discharg p either sequest level dissolv p high mgl releas downstream sediment level low mgl meanwhil continu mobil downstream sediment like due ongo desorpt exterior part fe oxyhydr oxid high aqueous p level ii dissolut bear ca phosphat low dissolv p level find clear demonstr point sourc p stream river wwtp may result perman long term releas contamin streamb sediment
|
D001151;D014874
|
T121;T196;T131
|
36,272,606
|
gap fill hybrid approach hour pm predict high spatial resolut multi sourc aod data despit grow interest satellit deriv estim ground level pm concentr model hour pm level high spatial resolut complet coverag larg studi domain remain challeng primari model challeng lie presenc miss data aerosol optic depth aod limit data resolut singl platform satellit aod product address issu develop gap fill hybrid approach estim full coverag hour ground level pm concentr high spatial resolut km use multi platform multi scale satellit deriv aod product specif fill gap downscal multi sourc aod geostationari ocean color imag goci multi angl implement atmospher correct maiac modern era retrospect analysi research applic version merra use hybrid data fusion approach fuse hour aod full coverag use hour pm predict high spatial resolut km demonstr applic propos approach assess perform use data collect northeastern asia fuse hour aod data show high accuraci mean absolut error correl coeffici valid aerosol robot network aeronet aod aod base pm predict model show good predict accuraci cross valid r root mean squar error gm respect given high resolv pm predict captur tempor trend peak pm pollut scenario conclud propos hybrid approach effect combin multi sourc satellit aod deriv subsequ pm distribut high spatial tempor resolut
|
D000397;D000393
|
T131;T069;T080
|
36,272,605
|
effect shipwreck spatiotempor dynam metalloid sediment seafood safeti bay bengal metalloid pollut shipwreck activ drawn signific concern due persist threat marin ecosystem human health investig spatiotempor distribut pollut characterist risk sourc potenti impact metalloid sediment seafood bay bengal nearbi open beach shipwreck yard bangladesh collect sediment seafood sampl expos control site dri wet season concentr element includ cadmium arsenic lead chromium manganes copper zinc iron tin antimoni nickel cobalt molybdenum vanadium selenium thallium measur use valid induct coupl plasma mass spectrometri icp ms method base pollut indic enrich factor geoaccumul index pollut index pollut load index lead arsenic cadmium selenium copper zinc tin dri season show higher contamin compar wet concentr increas season fluctuat sediment cadmium arsenic pose relat higher moder ecolog risk health risk analysi indic lead cadmium inorgan arsenic estim seafood speci pose possibl health threat general popul possibl ecolog health risk metalloid combin base ecolog risk index sediment hazard index seafood respect sourc apportion suggest anthropogen activ uncontrol shipwreck oper last four decad largest pollut domin contribut metalloid concentr therefor data may inform mitig strategi emiss control shipwreck yard protect marin ecosystem local popul
|
D001151;D019216;D014874;D012643
|
T121;T196;T123;T131
|
36,272,604
|
compar toxicolog assess three soil pollut differ level hydrocarbon heavi metal use vitro vivo approach biolog effect induc pollut present soil togeth chemic physic character good indic provid general overview qualiti howev exist studi toxic associ soil contamin mixtur pollut appli vitro vivo model scarc work three soil name soil soil soil pollut differ concentr hydrocarbon heavi metal evalu use differ organ repres human hepg human cell line environment exposur yeast saccharomyc cerevisia gram negat bacterium pseudomona putida vivo evalu annelid enchytraeus crypticus vitro assay show solubl fraction soil present highest level heavi metal repres great impact viabil hepg cell cerevisia organ extract soil caus slight decreas viabil hepg cell addit vivo experi show soil affect surviv reproduct e crypticus altogeth result provid general overview potenti hazard associ three specif contamin site varieti organ show differ concentr similar pollut affect highlight relev test organ solubl extract vitro safeti assay soil perform
|
D012989;D019216
|
T131;T196
|
36,272,603
|
deciph effect antibiot nitrogen remov bacteri communiti autotroph denitrif system three dimension biofilm electrod reactor studi three dimension biofilm electrod reactor ber construct effect metronidazol mnz nitrogen remov perform bacteri communiti autotroph denitrif system evalu result show nitrogen remov decreas slight mnz concentr increas specif nitrat nitrogen remov effici decreas within h addit mgl mnz respect ber show excel mnz degrad abil especi concentr mgl mnz remov effici could high within h averag remov rate increas mnz concentr increas high throughput sequenc result show signific chang bacteri communiti differ mnz concentr antibiot concentr increas relat abund hydrogenophaga silanimona increas without antibiot respect antibiot concentr mgl chang antibiot concentr alter abund gene involv nitrogen metabol redund analysi show mnz remov effici posit correl sbr sc hydrogenophaga silanimona denitratesoma wherea remov effici nitrat nitrogen total nitrogen negat correl genera result studi provid theoret basi studi toxic effect antibiot denitrif process also provid guidanc control antibiot nitrogen pollut ecosystem
|
D058440;D009584
|
T123;T196;T067
|
36,272,601
|
microplast baltic sea review distribut process sourc analysi method regulatori polici microplast pollut issu great concern scientist government bodi ecolog organis general public microplast pollut widespread great environment problem account potenti toxic marin biota human health today almost world sea ocean pollut microplast baltic sea semi enclos reservoir brackish water hotspot contamin term eutroph presenc organ matter microplast quit intens base data studi marin litter microplast baltic sea number microplast baltic sea water particlesm sediment particleskg amount prove water sediment baltic sea heavili contamin microplast articl provid comprehens review microplast origin transport rout baltic sea data present concentr microplast surfac water sediment sea sand extract method use microplast techniqu also present possibl limit water sediment sampl method microplast determin summaris take account sampl tool volum depth extract separ filtrat visual sort outlin sampl prepar techniqu microplast analysi review also focus problem obtain data relev develop mathemat model necessari monitor trend spread microplast baltic sea final sever import law polici place baltic state control manag microplast pollut region highlight
|
D000080545;D014874
|
T131;T122
|
36,272,560
|
divers invertebr visual opsin span protostomia deuterostomia cnidaria across eumetazoan abil perceiv respond visual stimuli larg mediat opsin famili protein belong g protein coupl receptor gpcr superclass lineag specif gain loss led strike divers number type spectral sensit confer visual opsin gene express review divers visual opsin differ opsin gene express well studi protostom invertebr deuterostom cnidarian group discuss function signific opsin express differ spectral tune among lineag case opsin evolut link detect relev visual signal includ sexual select color trait host plant featur instanc variat opsin direct link function ecolog differ overal array opsin express pattern sensit across invertebr lineag highlight divers opsin eumetazoan ancestor labil natur opsin evolutionari time
|
D055355;D003063
|
T123;T116;T204
|
36,272,558
|
dynorphin opioid receptor signal opioid receptor signal part mediat suppress lutein hormon releas late lactat rat follicular develop ovul profound suppress lactat suppress suggest due suckl induc inhibit kisspeptin gene master regul reproduct arcuat nucleus arc subsequ inhibit pulsatil gonadotropin releas hormon gnrh gonadotropin releas present studi examin whether hypothalam opioid receptor kor opioid receptor mor signal mediat suppress lutein hormon lh releas induc suckl stimulus late lactat rat central administr select kor antagonist block suppress lh releas day lactat howev central administr select mor antagonist fail block suppress suckl stimulus signific increas number fos marker neural activ posit pdyn dynorphin gene express cell paraventricular nucleus pvn supraopt nucleus son arc taken togeth result suggest central kor signal mor signal least part mediat suppress lh releas induc suckl stimulus late lactat pvn son dyn neuron may involv suppress rat
|
D004399;D017473
|
T123;T116;T192
|
36,272,557
|
discov sex age implic edg human connectom determin import vertic larg graph eg googl pagerank case graph world wide web facilit construct excel web search engin return import hit correspond submit user queri interest find import edg instead vertic larg graph receiv much less attent examin human structur braingraph connectom identifi diffus magnet reson imag dmri method edg connect cortic subcort gray matter area weight fiber strength measur number discov fiber tract along edg identifi sever singl import edg braingraph whose high low weight impli sex age subject observ call edg implic edg sinc sole weight one infer sex subject accuraci age group accuraci argu brain connect import one character sex age subject surpris edg impli male sex most locat anterior part brain impli femal sex most posterior region addit inter hemispher implic edg male one intra hemispher one predomin femal edg pioneer method find sex age implic edg also appli character biolog medic properti includ neurodegen psychiatr diseas besid sex age subject larg high qualiti neuroimag dataset becom avail emphas contribut identifi statist valid singl brain connect relat sex age subject larg robust dataset knowledg result unpreced aspect
|
D063132
|
T017;T091
|
36,272,556
|
effect long term covid confin music stimul mental state brain activ young peopl corona virus diseas covid pandem may negat emot impact individu studi investig effect long term lockdown music young peopl mood neurophysiolog respons prefront cortex pfc fifteen healthi young adult recruit pfc activ acquir use function near infrar spectroscopi condit rest stroop music stimul depress anxieti stress scale mental scale score simultan record mix effect model pair test one way anova spearman analys adopt analys experiment paramet stress anxieti depress level increas signific day day term reaction time stroop stroop faster day day p p relat concentr chang oxyhemoglobin signific higher premus condit music stimul postmus stroop intens function connect shift inter intracerebr time conclus reduc hemodynam respons pfc healthi young adult associ negat emot especi anxieti lockdown immedi music stimul appear improv effici alter pattern connect pfc
|
D009146;D000086382
|
T047;T170;T067
|
36,272,523
|
insular cortex activ food specif inhibitori control associ academ achiev children inhibitori control ic usual poorer children overweight obes associ unhealthi eat behavior lower academ achiev food specif ic task depict salient unhealthi food may sensit predict fat accumul unhealthi behavior tradit ic task howev neural activ pattern respons food specif ic remain unclear especi develop children brain investig brain activ associ food specif ic children accumul fat mass
|
D000076363
|
T080
|
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