PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
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101
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stringlengths 4
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|---|---|---|---|
36,272,517
|
lipid uniqu alter rate insulin aggreg lower toxic amyloid aggreg amyloid format hallmark mani medic diseas includ diabet type alzheim parkinson diseas patholog condit misfold protein self assembl form oligom fibril structur heterogen aggreg exhibit larg varieti shape form grow bodi evid point drastic chang lipid profil organ affect amyloidogen diseas studi investig extent individu phospho sphingolipid well mixtur impact insulin aggreg result show lipid mixtur uniqu alter rate insulin aggreg simultan chang secondari structur protein aggreg grown presenc structur differ protein lipid aggreg impact cell viabil differ extent use distinct mechan toxic find suggest irrevers chang lipid profil organ may trigger format toxic protein speci turn respons onset progress amyloidogen diseas
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D007328;D010300
|
T125;T121;T047;T116
|
36,272,494
|
qing xin jie yu granul inhibit ferroptosi stabil atherosclerot plaqu regul gpxxct signal pathway qing xin jie yu granul qxjyg integr tradit chines medicin formula use treat atherosclerot cardiovascular diseas random control trial found qxjyg reduc cardiovascular event experi also verifi qxjyg attenu remodel intestin flora
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D000079403;D058226
|
T046;T020;T031;T043
|
36,272,493
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identif high throughput quantif baicalein metabolit plasma urin scutellaria baicalensi georgi contain varieti function compound use tradit drug centuri baicalein highest amount flavonoid found scutellaria baicalensi georgi exert various pharmacolog activ might promis drug treat covid
|
D000086382;D044950
|
T121;T047;T067;T109
|
36,272,492
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morus alba l root decreas melanin synthesi via sphingosin phosphat signal bf cell morus alba l long use beauti mani asian countri region includ anti age hyperpigment
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D031625;D008545;D008546
|
T191;T050;T002
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36,272,491
|
integr network pharmacolog pharmacolog evalu explor protect mechan ershiwuwei zhenzhu pill ischem stroke ershiwuwei zhenzhu pill ezp repres classic formula tibetan medicin common use treatment various cerebrovascular diseas includ ischem stroke nevertheless efficaci potenti mechan treat yet investig
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D004365;D000083242
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T123;T047;T121
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36,272,490
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xinfeng capsul inhibit inflamm oxid stress rheumatoid arthriti regul linc activ nrfho pathway xinfeng capsul tradit chines medicin compound clinic use year treatment rheumatoid arthriti ra ankylos spondyl osteoarthr extracurricular lesion howev molecular role xfc treatment ra remain unclear
|
D001169;D001172;D000070918
|
T047;T050;T025
|
36,272,410
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hotspot mutat structur enl yeat domain link aberr transcript condens cancer grow evid suggest preval transcript condens chromatin yet mechan format function signific remain larg unclear human cancer seri mutat histon acetyl reader enl creat gain function mutant increas transcript activ abil show mutat cluster enl structur acetyl read yeat domain trigger aberr condens nativ genom target multival homotyp heterotyp interact mechanist mutat induc structur chang yeat domain enl two disord region oppos charg incorpor extrins elong factor requir enl condens format extens mutagenesi establish condens format driver oncogen gene activ furthermor express enl mutant beyond endogen level lead non function condens find provid new mechanist function insight cancer associ condens support condens dysregul oncogen mechan
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D000088202;D009369
|
T026;T191
|
36,272,409
|
dna topolog regul pam cas interact dna unwind enabl near pamless cleavag thermophil cas crispr cas mediat genom edit depend pam recognit initi dna unwind pam mutat abolish cas bind prohibit edit identifi cas thermophil alicyclobacillus tengchongensi pam interact robust regul dna topolog atca relax pam n cnnn n rnna r ag abl bind cleav target mutat pam pam mutat dna underwound topolog atca exhibit enhanc bind affin high cleavag activ mechanist atca uniqu loop motif dock dna major groov interact regul dna topolog import atca show near pamless edit supercoil plasmid e coli mammalian cell atca exhibit broad pam prefer edit plasmid effici effect base edit four endogen loci repres potenti power tool near pamless edit
|
D064113;D004926
|
T040;T007
|
36,272,408
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rig receptor adopt two differ conform distinguish host viral rna ligand rig essenti innat immun receptor detect respond infect rna virus rig specif recogn uniqu molecular featur viral rna molecul select distinguish close relat rnas abund host cell physic basi exquisit select reveal seri high resolut cryo em structur rig complex host viral rna ligand studi demonstr rig activ sampl doubl strand rnas cytoplasm distinguish adopt two differ type protein fold upon bind viral rna rig adopt high affin conform conduc signal host rna induc autoinhibit conform stimul rna releas coupl protein fold rna bind select rig distinguish rna molecul differ littl one phosphat group therebi explain molecular basi select antivir sens induct autoimmun upon rig dysregul
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D012367;D053487
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T126;T116;T114
|
36,272,401
|
bone marrow periost skelet stemprogenitor cell make distinct contribut bone mainten repair fundament question bone biolog concern contribut skelet stemprogenitor cell sscs bone marrow versus periosteum bone repair found sscs adult bone marrow identifi base lepr cre adiponectin crecreer express sscs adult periosteum identifi base gli creert express steadi state condit new bone aros primarili bone marrow sscs bone injuri ssc popul began prolifer made differ contribut bone repair drill injuri primarili repair lepr adiponectin bone marrow sscs convers bicort fractur primarili repair gli periost sscs though lepr adiponectin bone marrow cell transient form trabecular bone fractur site gli periost cell also regener lepr bone marrow stromal cell express hematopoiet nich factor fractur site differ bone injuri thus repair differ sscs periost cell regener bone marrow stroma non stabil fractur
|
D001853;D052242
|
T123;T023;T116;T024
|
36,272,399
|
associ dexmedetomidin administr outcom critic ill patient sepsi associ acut kidney injuri investig associ dexmedetomidin administr outcom critic ill patient sepsi associ acut kidney injuri sa aki
|
D020927;D058186;D018805
|
T121;T109;T037;T047;T046
|
36,272,394
|
marker infect inflamm associ post thrombectomi mortal acut stroke explor relationship marker infect inflamm mortal patient acut ischem stroke underw thrombectomi
|
D000083242;D000086382;D020521;D002545
|
T047;T046;T067
|
36,272,357
|
analysi bind warfarin glyoxal methylglyox modifi human serum albumin ultrafast affin extract ultrafast affin extract uae affin microcolumn contain immobil human serum albumin hsa employ evalu effect advanc stage glycat hsa bind warfarin common site specif probe sudlow site protein modif hsa glyoxal go methylglyox mgo consid go mgo known import format mani type advanc glycat end product free drug fraction measur uae warfarin solut contain normal hsa hsa modifi go mgo level seen serum diabet free fraction measur go modifi hsa gave associ equilibrium constant rang ph c valu signific differ valu determin method warfarin normal hsa similar studi use mgo modifi hsa gave associ equilibrium constant warfarin rang fold higher valu seen normal hsa differ signific confid level result valuabl futur bind studi base affin chromatographi method employ warfarin probe examin drug interact sudlow site hsa modifi form protein work also illustr uae use analysi time minut detect measur small chang bind drug unmodifi modifi form solubl bind agent protein
|
D014859;D000075462
|
T121;T116;T131;T109
|
36,272,356
|
evolut current state instrument analyt supercrit fluid chromatographi supercrit fluid chromatographi contribut signific chiral method develop semi prepar purif drug discoveri sensit issu analyt scale sfc valid use multi vendor inter lab studi quantit achir trace pharmaceut impur use sub particl gradient elut uv detect signific increas penetr sfc chiral achir qaqc applic howev still work done extra column dispers better previous generat yet techniqu often superfici call ultra high perform sfc uhpsfc simpli sub pack use dispers far high use sub particl requir extens hardwar modif use particl high effici howev common mean reduc system dispers ultra high perform liquid chromatographi uhplc result distort kinet perform sfc vendor need specifi provid standard plumb scheme allow full use sub fulli porous sub superfici porous particl reduc plate height h k consensus best perform dynam compress compens sinc vendor use differ co pump head temperatur result subtl differ flow composit vendor
|
D025924
|
T059
|
36,272,326
|
differenti effect ankl constraint foot placement control normal split belt treadmil mediolater ankl moment control contribut gait stabil ankl moment constrain walk shoe ridg underneath sole narrow mediolater support surfac previous studi ankl moment constraint result increas step width decreas degre foot placement control defin percentag varianc foot placement explain com state howev sinc previous studi perform split belt treadmil narrow ridg could fit insid gap belt evid whether effect attribut constrain ankl moment control avoid gap therefor investig effect ankl moment constraint depend whether particip walk normal treadmil split belt treadmil includ fourteen healthi young adult walk constrain ankl moment control result wider step width treadmil yet increas step width larger split belt treadmil compar normal treadmil found decreas degre foot placement control split belt treadmil whilst degre foot placement control increas normal treadmil conclud effect ankl moment constraint report previous studi confound use split belt treadmil futur research recommend use normal treadmil whenev possibl gap split belt treadmil might affect gait paramet
|
D000842;D000222
|
T040;T029
|
36,272,315
|
evalu autom presidio anonymis model unstructur radiat oncolog electron medic record australian set electron medic record emr contain valuabl inform clinic research howev presenc person identifi inform pii restrict use anonymis pii emr enabl clinic inform share research purpos sinc limit research relat anonymis australian emr perform microsoft presidio customis clinic document australian radiat oncolog inform system oi evalu
|
D057286;D018787
|
T170;T091;T073
|
36,272,309
|
prematur discontinu among individu epilepsi particip epilepsi self manag research intervent manag epilepsi well mew network conduct epilepsi self manag esm intervent develop test archiv clinic trial data analys mew network integr databas mew db howev trial particip fulli benefit esm due prematur discontinu program particip analysi sought identifi demograph clinic predictor prematur discontinu pd esm intervent avail mew db
|
D000073278;D004827;D047928
|
T033;T058;T046;T047
|
36,272,308
|
extens pharmacokinet variabl levetiracetam doctor awar levetiracetam present drug linear pharmacokinet current evid extens pharmacokinet variabl real clinic practic
|
D010889;D004827
|
T033;T121;T047;T109
|
36,272,276
|
applic surfac plasmon reson imag biosensor determin fibronectin laminin type iv collagen serum transit bladder cancer patient urotheli basement membran ubm contain type iv collagen laminin fibronectin urotheli neoplasm break ubm under urothelium invad lamina propria conceptu bladder cancer stage ta may demonstr disturb ubm structur well alter serum concentr studi compon aim studi determin blood serum concentr collagen iv laminin fibronectin bladder cancer patient quantif concentr correl various clinicopatholog paramet may use make accur predict identifi high risk patient studi includ patient bladder cancer confirm transurethr resect cystectomi patient diagnos cystiti chronica bph benign prostat hyperplasia collagen iv laminin fibronectin detect use surfac plasmon reson imag biosensor signific differ blood serum concentr studi biomark observ control group bladder cancer patient well nonmuscl invas muscl invas group roc analysi gave satisfactori result differenti control group bladder cancer group auc lower valu collagen iv nonmuscl invas muscl invas patient auc statist insignific differ laminin laminin concentr close correl tumour grade size recurr rate fibronectin tumour stage size morpholog collagen iv tumour stage grade recurr rate relat serum concentr present biomark urotheli basement membran may use bladder cancer detect determin tumour stage henc simplifi make therapeut decis
|
D001749;D015374
|
T191;T059;T075
|
36,272,275
|
proteoexcel tp develop simpl excel base tool surrog peptid select mass spectrometri base target proteom select surrog peptid play major role achiev reproduc accur quantif desir protein target proteom current avail peptid select tool suffer limit cover entir protein includ speci inflex appli exclus criteria develop excel base proteoexcel tp tool automat select appropri surrog peptid high flexibl term addit delet chang exclus criteria develop proteoexcel tp tool also valid comparison obtain peptid tool select previous report work first time develop excel base tool quick accur select surrog peptid entir protein famili speci tool uniqu advantag high user friend natur custom accord specif need research proteoexcel tp tool signific enhanc throughput quantit proteom analysi tool immens help scientist work field proteom signific minim effort accur select surrog peptid quantif endogen protein
|
D040901;D010455
|
T121;T116;T091
|
36,272,252
|
sonochem synthesi biolog evalu isoquinolin h oneisoindolin one deriv discoveri posit ago alloster modul paam ht c r effort devot discoveri develop posit alloster modul pam ht c r potenti advantag orthoster agonist like lorcaserin withdrawn market hand pursu posit ago alloster modul paam consid benefici particular agonist capabl affect potenc endogen agonist suffici search suitabl paam ht c r adopt silico base approach indic potenti hydroxycycloalkyl substitut isoquinolin one deriv ht c r major molecul interact site lorcaserin superior dock score compound along regioisomer methyleneisoindolin one deriv prepar via cu oac catalyz coupl iodobenzamid ethynylcycloalkanol ultrasound irradi accord vitro studi compound found potent select agonist also emerg paam ht c r wherea lorcaserin show paam activ accord sar studi isoquinolin h one appear better paam isoindolin one wherea presenc hydroxyl group appear crucial activ potent paam activ ht c r ec nm fold select toward ht c ht ht b compound identifi hit molecul compound show good stabil male balbc mice brain homogen remain h moder stabil presenc rat liver microsom remain h accept pk properti fast reach brain maintain brainplasma concentr ratio compound dose mgkg exhibit decreas trend food intak start day sd rat reach signific th day effect compar lorcaserin mgkg day thus first exampl paam ht c r compound medicin interest
|
D058826;D012701
|
T121;T123;T109
|
36,272,251
|
guaian type sesquiterpenoid various ring skeleton daphn bholua uncov molecular network structur revis previous report analogu genus daphn treasur hous secondari metabolit various biolog effect inspir daphn bholua fulli investig phytochem biolog first time seven undescrib guaian type sesquiterpenoid along thirteen known analogu target isol bholua use molecular network chemic structur configur establish via nmr spectroscopi analysi nmr ecd calcul snatzk method along singl crystal x ray diffract techniqu moreov two pair sesquiterpen isom either promin biolog properti unpreced skeleton revis mean comput assist structur elucid chemic shift calcul use deep learn etc inhibitori potenti isol acetylcholinesteras evalu vitro silico
|
D032364;D012717
|
T002;T109
|
36,272,240
|
virtual realiti base theori mind intervent schizophrenia preliminari efficaci result recent year grow bodi literatur support core natur function signific theori mind tom deficit schizophrenia find made tom impair promis treatment target howev despit encourag result complex make difficult develop new intervent even understand exact natur scope deficit yet investig suggest use modern technolog multilevel assess may help solv problem
|
D012559;D056345;D000076142
|
T078;T066;T048
|
36,272,220
|
mitochondria target supramolecular nanoplatform peroxynitrit potenti oxid therapi orthotop hepatoma oxid therapi generat reactiv oxygen speci ros via intracellular enzymat reaction achiev tumor ablat consid emerg approach cancer treatment herein nitric oxid combin oxid therapi report integr glutathion gsh sensit donor ph sensit cinnamaldehyd ca prodrug mitochondria target drug nanocarri prepar host guest interact cyclodextrin cd polyethylen glycol peg intern cancer cell ca releas acid endolysosom final induc ros generat mitochondria oxid therapi time target deliv mitochondria mitochondria target strategi realiz select releas mitochondria deplet intracellular predomin antioxid gsh enhanc oxid therapi ca furthermor peroxynitrit onoo strong peroxid nitrat capabl produc mitochondria reaction ros reactiv nitrogen speci rns mediat oxid therapi generat onoo mitochondria effect facilit mitochondri membran permeabil caus mitochondri dysfunct final induc mitochondri apoptosi antitumor abil mitochondria target onoo potenti oxid therapi fulli investig subcutan orthotop hepatoma model nude mice innov strategi select generat onoo mitochondria may serv afflatus futur applic cancer treatment
|
D006528;D008113
|
T191
|
36,272,219
|
enhanc manipul tumor microenviron nanomotor synergist therapi malign tumor tumor microenviron tme play critic role growth metastasi tumor tissu provid promis way treat malign tumor via manipul tme howev develop proper strategi effect control tme still challeng herein ce peg msn pt capmp nanomotor fabric spontan move tumor tissu concurr perform enhanc manipul various tumor microenviron includ copper level hypoxia local temperatur reactiv oxygen speci ros effect tumor therapi capmp nanomotor consist janus platinum mesopor silica core acyl thiourea group copper chelat conjug polyethylen glycol surfac chlorin e photosensit pore therapi acyl thiourea group capmp would captur express copper tumor tissu tumor cell caus dramat copper defici tumor chlorin e charg ros generat tumor via photodynam process would trigger nm irradi platinum layer capmp serv phototherm agent produc rapid rais local temperatur nm irradi meanwhil convert express h tumor tissu via catalyt reaction product drove capmp sustain movement promot effici copper captur revers hypox environ tumor tissu larg deep area promot generat properti capmp vitro vivo experi demonstr rais local temperatur enhanc concentr perform signific damag tumor tissu primari tumor elimin copper defici hypoxia revers hinder migrat tumor cell metastasi inhibit result effect strategi treat malign tumor
|
D010778;D053758
|
T061;T073
|
36,272,218
|
biocomposit cultur enhanc differenti dopamin like neuron sh syy cell model studi parkinson diseas phenotyp studi under neurodegen process parkinson diseas pd tradit util cell cultur grown two dimension surfac biomimet three dimension cell cultur platform develop better emul featur brain natur microenviron use bioengin brain like tissu model compos silk hydrogel composit studi microenviron contribut develop perform dopaminerg like neuron dlns compar cultur sh syy cell differenti microenviron enrich dlns concomit reduct prolif capac neurodevelopment process addit dln cultur sensit oxid stress elicit pd relat neurotoxin methyl phenylpyridinium mpp mpp induc transcriptom profil chang specif differenti dln cultur replic dysfunct neuron signal pathway mitochondri dynam implic pd overal physiolog relev platform resembl use tool studi dopamin neuron biolog interrog molecular mechan under neurodegener pd
|
D010300;D009447
|
T047;T191
|
36,272,208
|
perceptu similar modul effect learn variabl face recognit face recognit challeng classif task human perform effortless familiar face recent studi emphas import exposur high variabl appear ident perform task howev studi explicit measur perceptu similar learn imag imag present test may account advantag learn high variabl particular random select test imag like perceptu similar learn high variabl imag dissimilar learn low variabl imag dissoci effect learn variabl studi test perceptu similar collect human similar rate studi test imag use measur independ manipul variabl learn imag perceptu similar test imag differ group particip learn face ident low high variabl set imag learn phase follow face match test experi face recognit task experi present novel imag learn ident perceptu dissimilar similar learn imag result experi show perceptu similar studi test rather imag variabl learn per se predict face recognit conclud learn high variabl improv face recognit perceptu similar perceptu dissimilar imag find may specif face similar evalu domain
|
D000066499
|
T041
|
36,272,203
|
general visuomotor adapt associ use depend learn across differ movement workspac limb postur use depend learn investig extent although motor pattern obtain use depend learn general across differ movement condit remain understood investig generaliz use depend learn determin visuomotor adapt associ use depend learn general across differ workspac limb postur experi particip first adapt visuomotor rotat reach given start posit toward train target given limb postur concurr experienc repetit passiv movement vari start posit exp vari limb postur exp follow adapt rotat reach origin start circl transfer target regardless workspac limb postur experienc passiv train facilit visuomotor adapt transfer session indic visuomotor adapt general across differ movement condit howev extent general decreas experienc workspac limb postur deviat origin condit experienc find indic use depend learn result motor instanc workspac limb postur specif although still use enhanc general motor learn across vari condit
|
D011597;D009069
|
T047;T041
|
36,272,202
|
individu differ work memori capac conscious process explain explicit implicit learn outcom physic educ studi examin effect explicit versus implicit learn method motor learn self efficaci year old student n practic basketbal layup physic educ main aim test effect student verbal work memori capac wmc propens conscious motor process cmp explicit implicit learn outcom student practic basketbal layup three week one sessionweek regular pe class practic condit either promot explicit implicit learn verbal wmc cmp propens measur separ posttest student signific improv layup perform techniqu self efficaci differ note intervent group explicit vs implicit student verbal wmc cmp propens differenti predict learn outcom explicit implicit learn group therefor pe set explicit implicit learn method seem similar improv movement skill studi need examin condit individu constraint verbal wmc propens conscious process influenc effect explicit implicit learn
|
D008570;D007206
|
T054;T041
|
36,272,201
|
preclin evalu new c label benzo dioxan pet radiotrac brain c adrenerg receptor one nine subtyp adrenerg receptor ar brain c ar play essenti role emot memori implic neuropsychiatr disord includ depress alzheim diseas substanc use disord schizophrenia recent develop c ar specif positron emiss tomographi pet radiotrac c orm show promis imag c ar brain herein prepar high potent c label benzo dioxan deriv compar c orm aim improv specif bind signal evalu vivo rodent brain pet imag elsevi inc right reserv
|
D018341;D010879
|
T109;T116;T192
|
36,272,200
|
energi expenditur glucos lower effect differ exercis modal diabet mellitus hypoglycaemia serious complic exercis patient type diabet mellitus tdm aim studi test energi expenditur degre glucos lower effect differ exercis modal
|
D003924;D007003
|
T047
|
36,272,199
|
comammox biogeographi subject anthropogen interfer along high altitud river recent discoveri comammox nitrospira perform complet ammonia oxid nitrat overturn long held dogma two step nitrif earth yet littl known effect urban interfer distribut use gene centric metagenom provid first blueprint comammox communiti biogeographi environment driver along high elev river flow largest citi vulner qinghai tibetan plateau studi confirm wide presenc divers yet uncultur comammox clade b across wet dri season averag time abund clade amoa gene water sediment respect speci identifi freshwat drink water treatment plant domin comammox guild suggest plateau river share similar comammox assemblag habitat type compar urban area harbor abund canon nitrospira identifi wastewat averag upstream suburban reach smaller human popul larger proport comammox ammonia oxid prokaryot abund nitrospira sublineag iii higher content nitrat nitrit water antibiot water sediment may restrain comammox nich nitrifi urban area random forest analysi reveal lincosamid quinolon import antibiot predictor nich differenti comammox canon nitrifi water macrolid sediment final incub experi demonstr higher activ contribut benthic comammox suburban area potenti ammonia oxid rate urban reach contribut variat signific negat relat macrolid major compon overal studi highlight anthropogen activ hamper advantag riverin complet nitrifi canon two step one
|
D000641;D001105
|
T194;T121;T197
|
36,272,198
|
stage process challeng drawback lab full scale studi review respons grow global resourc scarciti wastewat increas seen valuabl resourc recov valoris benefit societi rather anoth wast need treatment dispos convent wastewat treatment plant wwtps oxidis organ matter present wastewat instead recov feedstock biomateri produc energi form bioga contrast stage capabl produc concentr stream organ matter readi valoris ideal suit retrofit exist larg plant technolog base principl high rate activ sludg process favour biosorpt storag oxid paper summar peer review research pilot scale full scale studi stage process real condit highlight key oper paramet major publish studi sludg retent time srt identifi key oper paramet optim srt day seem maxim redirect influent cod sludg flux simultan keep miner total influent cod key optim paramet hydraul resid time min dissolv oxygen level mgl addit nutrient remov effici total nitrogen total phosphorus observ influenc mix settl effici remain larg underexplor well impact wet weather flow temperatur overal recoveri effici hinder provid recommend aspect evolut model effort stage process also critic review role extracellular polymer substanc remain unclear measur differ great accord differ studi protocol better understand settl process ad limit stokesian threshold floccul measur sludg volum index could help reach better understand stage process reliabl model help new unit process find place whole treatment chain help transit wwtps toward wastewat resourc recoveri facil
|
D012722;D062065
|
T083;T069
|
36,272,197
|
comprehens insight impact pretreat anaerob digest wast activ sludg perspect organ matter composit thermodynam multi omic although various pretreat appli promot anaerob digest wast activ sludg mechan regard impact pretreat anaerob digest well address studi effect acid alkali thermal pretreat anaerob digest comprehens investig perspect organ matter composit thermodynam multi omic result show acid alkali thermal pretreat increas methan product potenti respect compar control protein secondari structur disrupt pretreat shift helix sheet random coil antiparallel sheetaggreg strand thermodynam floccul process control short rang interfaci interact describ extend derjaguin landau verwey overbeek xdlvo theori posit correl r p organ matter solubil pretreat floccul energi barrier pretreat acid alkali thermal time higher control group respect multi omic analysi confirm pretreat promot amino acid tryptophan tyrosin phenylalanin aspart glutam metabol energi metabol abc transport vitamin metabol moreov comparison upregul differenti express protein dep reveal amino acid metabol thermal treatment best promot effect carbohydr metabol alkali treatment best promot effect lipid metabol acid treatment advantag result differ anaerob digest effici studi provid depth understand impact differ pretreat anaerob digest practic implic choic proper pretreat technolog biosolid
|
D012722;D014865
|
T069;T057
|
36,272,196
|
element sulfur base autotroph denitrif construct wetland effici approach nitrogen remov low cn wastewat construct wetland cws integr sulfur autotroph denitrif stimul high rate nitrogen remov carbon limit wastewat hold particular applic prospect due excess carbon sourc addit high effici good stabil studi conduct element sulfur base construct wetland scw tradit construct wetland cw differ cn explor feasibl mechan nitrogen remov low cn wastewat compar cw scw demonstr robust nitrogen remov case low cn influent influent cn control scw observ total nitrogen tn nitrat remov effici correspond remov rate g nm time cw respect nitrat remov rate constant k scw time higher cw cn furthermor nitrogen remov sulfur autotroph denitrif sad scw also contribut sulfat product moreov combin system cw scw prove effici oper mode simultan remov total ammonia nitrogen tan nitrat scw rich microbi communiti improv sulfur oxid genera eg thiobacillus sulfurimona select enrich affect perform element sulfur base denitrif process nitrat reduct pathway overwhelm denitrif dissimilatori nitrat reduct process find offer element sulfur base autotroph denitrif construct wetland excel potenti enhanc nitrogen remov carbon limit wastewat
|
D062065;D053833
|
T083;T070;T069
|
36,272,174
|
gut microbiota dysbiosi exagger ammonia induc tracheal injuri via tlr signal pathway ammonia toxic air pollut caus sever respiratori tract injuri anim human gut microbiota dysbiosi found involv develop respiratori tract injuri induc air pollut howev specif mechan requir investig found inhal ammonia induc tracheal injuri reduc express claudin increas express mucac tlr myd nf b cytokin tnf il il il also alter tracheal microbiota composit spearman correl analysi indic gut microbiota dysbiosi posit correl tlr level trachea antibiot deplet intestin microbiota treatment reduc sever ammonia induc tracheal injuri via tlr signal pathway microbiota transplant induc tracheal injuri via tlr signal pathway even without ammonia exposur result indic gut microbiota dysbiosi exagger ammonia induc tracheal injuri via tlr signal pathway addit ruminococcus torquesgroup faecalibacterium unclassifiedflachnospiracea may key gut microbiota contribut alter tracheal microbiota composit
|
D064806;D000069196
|
T047;T046;T001;T007
|
36,272,173
|
research molluscicid activ molecular mechan arecolin pomacea canaliculata pomacea canaliculata invas snail china advers affect agricultur crop yield ecolog environ human health paper studi molluscicid activ mechan arecolin p canaliculata molluscicid activ test show arecolin exhibit strong toxic p canaliculata lc valu h mgl mm shell diamet addit molluscicid toxic negat correl size snail snail mm shell diamet choos mechan research result microstructur biochemistri show arecolin mgl strong toxic effect gill main sign loss cilia gill filament moreov arecolin signific decreas oxygen consumpt rate ammonia excret rate inhibit acetylcholinesteras ach chang protein express studi itraq downregul protein found among cilia flagella associ like pccfp rootletin like pcroo select candid target protein bioinformat analysi rna interfer rnai adopt verifi function pccfp pcroo result show arecolin treat mortal cilia shed rate pcroo rnai treat group signific lower control group result indic arecolin bind well protein pcroo lead drop gill cilia affect respiratori metabol acceler entri hemolymph inhibit ach final lead death p canaliculata
|
D008975;D049851
|
T131;T204
|
36,272,156
|
stabl core shell structur nanocryst cs pbbr zn moi achiev situ surfac reconstruct strategi optic anticounterfeit zero dimension cs pbbr nanocryst ncs possess attract photoluminesc pl properti featur facil chemic synthesi make promis applic luminesc materi howev cs pbbr remain sensit polar solvent thermal stimuli soft ionic natur cs pbbr dynam behavior surfac ligand herein strategi control situ surfac coordin reaction develop fabric stabl ncs cs pbbr zn moi core shell structur found cs pbbr surfac regul use mercaptoimidazol call moi coordin nh group moi zn critic format cs pbbr zn moi core shell ncs meanwhil thick zn moi shell facil control growth time solubl moi zn oac h ethyl acet compar bare cs pbbr cs pbbr zn moi ncs exhibit high improv polar solvent resist thermal stabil combin sensit cs pbbr stabil cs pbbr zn moi use two ncs pl secur ink fabric optic anticounterfeit label thus dispos reusabl optic anticounterfeit label achiev chang extern dual stimuli work provid novel strategi enhanc stabil cs pbbr develop potenti interest applic anticounterfeit technolog
|
D053758
|
T073
|
36,272,107
|
function coval organ framework peptid polym assist surfac modif applic protein detect although coval organ framework cof receiv extens attent biomed research due uniqu properti applic still hinder challeng incorpor cof function biomolecul sinc peptid shown advantag biomed applic herein propos function cof peptid polym assist surfac modif strategi furthermor method base peptid function cof protein detect also develop demonstr applic potenti help polym peptid horseradish peroxidas attach onto cof high surfac densiti develop method achiev simpl sensit detect secret protein acid rich cystein specul facil method propos work prepar peptid function cof benefit protein detect also promot biomed applic cof
|
D000073396
|
T109
|
36,272,098
|
viral shed year follow first episod genit hsv infect herp simplex virus type hsv lead caus first episod genit herp mani countri
|
D006558;D018259;D015658;D006561
|
T047;T005
|
36,272,033
|
slca facilit epitheli cell ferroptosi via cebp pak axi ulcer coliti emerg evid suggest ferroptosi involv pathogenesi ulcer coliti uc howev key regul process remain uncertain studi aim explor role solut carrier slc famili member slca regul ferroptosi uc express slca signific increas posit associ prostaglandin endoperoxid synthas ptgs tissu sampl patient uc moreov seri vitro vivo experi show slca knockdown mark suppress ferroptosi rna sequenc reveal slca inhibit express p rac activ kinas pak pak knockdown abolish effect slca ras select lethal rsl induc ferroptosi caco cell furthermor chromatin immunoprecipit chip western blot analysi demonstr slca negat regul pak express ccaat enhanc bind protein beta cebp depend manner collect find indic slca facilit ferroptosi uc promot cebp express bind activ inhibit pak express suggest target slca cebp pak axi mediat ferroptosi may promis therapeut altern uc
|
D003093;D000079403
|
T047;T043
|
36,272,024
|
lenacapavir first approv lenacapavir sunlenca long act capsid inhibitor human immunodefici virus type hiv develop gilead scienc inc avail oral tablet inject solut latter slow releas formul allow bi annual subcutan administr august lenacapavir receiv first approv eu use combin antiretrovir adult multi drug resist hiv infect otherwis possibl construct suppress anti viral regimen articl summar mileston develop lenacapavir lead first approv treatment hiv infect
|
D015658;D019380;D015497
|
T121;T047;T005
|
36,272,023
|
use mobil applic increas therapeut adher adult systemat review failur compli therapeut treatment impli negat repercuss patient qualiti life social environ health system use inform communic technolog especi mobil applic favor increas global therapeut adher figur object studi character use mobil applic strategi increas therapeut adher adult systemat literatur review web scienc scopus perform follow prefer inform element systemat review meta analysi inform year public studi popul medic condit particip main characterist function mobil applic method tool use measur treatment adher extract includ articl risk bias assess twelv random control trial rcts publish english may includ chronic diseas most address intervent mobil applic report function mobil applic remind educ modul two way communic game tool moriski medic adher scale eight item medic adher questionnair self report adher among other use evalu report treatment adher conclus includ treatment intervent use mobil applic clinic practic proven benefici improv therapeut adher howev necessari develop high qualiti clinic trial size durat general result justifi use convent health servic
|
D063731
|
T170
|
36,271,991
|
assess phenotyp divers within goliath chicken popul benin goliath chicken new strain poultri origin depart zou commune agbangnizoun republ benin characterist chicken strain well studi purpos studi character phenotyp divers goliath chicken depart zou couffo total bird made femal male sampl use morpholog descriptor result show wide variat plumag colour within overal popul domin black white red black white plumag domin femal red male colour beak shank common chicken sex yellow eye common femal red eye preval male comb wattl colour red sex morphometr sexual dimorph mark bodi measur male bird signific superior averag bodi weight kg male kg femal popul cluster three morphotyp accord gradient size chicken bohicon agbangnizoun one hand zagnanado toviklin form group respect group includ individu djidja observ divers due variat individu molecular character recommend thorough knowledg goliath chicken strain benin
|
D002645
|
T012
|
36,271,974
|
use object measur examin effect suspect filler similar eyewit identif perform select filler includ polic lineup one must consid level similar suspect potenti filler order reduc misidentif innoc suspect stand therefor import filler share degre similar import increas suspect filler similar much render task difficult reduc correct identif guilti suspect determin much similar yield optim identif perform focus propos studi extant research lineup construct provid somewhat mix result part like similar often defin relat term due subject natur similar current studi propos experi manipul suspect filler similar via multidimension scale model construct use object facial measur test propiti heterogen diagnost featur detect hypothes predict advantag lineup low similar filler term discrimin
|
D021641;D011939
|
T041
|
36,271,971
|
proteom alter clonal isol establish human pancreat cancer cell line clonal isol integr step numer workflow genom edit cell engin compris isol singl progenitor cell defin cell line popul subsequ expans obtain monoclon cell popul process associ transient loss cell cell contact absenc multicellular microenviron previous studi reveal transcriptom chang upon clonal isol cell line specif extent sinc transcriptom alter partial reflect proteom level sought investig impact clonal isol cellular proteom depth protein three establish pancreat cancer cell line show clonal isol impact cellular proteom howev cell line specif extent affect differ biolog process also depend isol method demonstr differ impact clonal isol mesenchym epitheli deriv cell line main affect cell prolifer metabol cell adhes cellular stress result bear relev field genom edit cell engin highlight need consid impact clonal isol interpret data stem experi includ step
|
D020543;D010190
|
T123;T191;T116
|
36,271,963
|
challeng osteoporosi treatment initi geriatr patient admit hip fractur pathway osteoporosi often untreat especi older peopl studi found low prescrib rate osteoporosi treatment medic older peopl admit hip fractur pathway factor associ greater odd prescrib osteoporosi medic categor patient relat physician relat system relat factor
|
D050071;D010024;D006620;D058866
|
T121;T047;T037
|
36,271,960
|
symmetri break longitud bifurc free boundari problem model small plaqu three dimens atherosclerosi one lead caus death usa worldwid begin lesion intima arteri wall allow ldl penetr intima oxid immun system consid oxid ldl danger substanc task macrophag attack incapacit macrophag becom foam cell lead format plaqu plaqu continu grow progress restrict blood flow possibl trigger heart attack stroke blood vessel tend circular two space dimension cross section model good approxim two space dimension model studi friedman et al j differ equ zhao hu j differ equ interest see whether true three space dimension stationari solut develop shall establish three space dimension stationari solut mathemat model initi develop atherosclerosi involv ldl hdl cholesterol macrophag foam cell model high nonlinear coupl system pdes free boundari interfac plaqu blood flow establish infinit branch symmetri break stationari solut bifurc annular stationari solut longitud direct
|
D058226;D050197
|
T047;T046;T020;T031
|
36,271,959
|
milk product perform ankol crossbr holstein friesian cattl differ product environ rwanda aim studi assess product perform dairi cattl three differ agro ecolog zone rwanda congo nilewestern waz central plateaucentr caz eastern plateaueast agro ecolog zone eaz singl visit multi subject survey conduct obtain inform dairi cattl perform farm breed group classifi ankol x holstein friesian af ankol crossbr ax pure holstein friesian f f higher p milk yield af zone except eaz af higher p milk yield ax zone across zone f produc l ax l af per day cow eaz highest averag milk yield howev signific differ caz differ observ af eaz af two zone indic agro ecolog zone target livestock develop activ rather addit factor feed avail farm level social econom market infrastructur consid rwanda
|
D008892;D003612
|
T168;T092;T057;T031
|
36,271,951
|
ost promiscu evolutionari biochem evalu hsd function cardiolipin metabol multifunct protein challeng difficult confirm pathomechan associ diseas caus genet variant human hydroxysteroid dehydrogenas hsd moonlight enzym least two structur catalyt unrel function hsd diseas origin describ disord isoleucin metabol clinic manifest subsequ shown link impair mtdna transcript process due defici function hsd mtrnase p complex surpris larg number most enzymat potenti clinic relev function attribut hsd recent hsd report exhibit phospholipas c like activ toward cardiolipin cl import mitochondri phospholipid assess physiolog role propos cl cleav function studi cl architectur live cell patient fibroblast differ genet background lipid environ use well establish lc msms cardiolipidom pipelin experi reveal measur effect cls indic hsd physiolog relev function toward cl metabol evolutionari constraint could explain broad rang report substrat hsd vitro combin essenti structur non essenti enzymat function protein could direct evolutionari trajectori toward improv former therebi increas flexibl bind pocket consist result present
|
D015094;D006913
|
T126;T116
|
36,271,948
|
saliva metabolom profil covid patient associ diseas sever coronavirus diseas covid strong link dysregul various molecular cellular physiolog process chang abund differ biomolecul includ metabolit may ultim use biomark diseas progress sever import earli stage readili distinguish patient like progress moder sever stage
|
D000086382
|
T047;T067
|
36,271,947
|
start dose select palbociclib chines patient breast cancer base popul kinet pharmacodynam model neutropenia neutropenia common advers event ae palbociclib oral cdk inhibitor breast cancer neutropenia increas risk infect even life threaten asian patient general suffer sever neutropenia palbociclib treatment label recommend reduct start dose asian patient therefor studi aim explor exposur respons e r relationship chines patient preliminarili generat scale start dose select palbociclib chines patient compar kinet pharmacodynam k pd pharmacokineticpharmacodynam pkpd model semi mechanist k pd model select develop basi real world data patient breast cancer describ time cours longitudin absolut neutrophil count anc longitudin anc data well describ popul k pd model reason paramet mean transit time mtt h feedback paramet baselin anc level circ l drug effect coeffici kd drug effect power covari includ final model model show palbociclib dose depend reduc anc level chines popul lower baselin anc level associ sever neutropenia dose select scale suggest palbociclib mg daili appropri chines patient circ higher l summari k pd model palbociclib well describ longitudin anc chines patient besid start dose select scale may provid refer clinician individu therapi
|
D001943;D009503
|
T047;T191
|
36,271,946
|
second extracellular proteas mediat matur vibrio mimicus hemolysin vibrio mimicus bacterium caus gastroenter human pathogen produc enterotox hemolysin call v mimicus hemolysin vmh secret extracellular inact kda protoxin convert kda matur toxin cleavag arg ser kda serin proteas term v mimicus trypsin like proteas vmta known mediat matur process howev strain includ strain es possess vmta gene present studi vmta negat strain found replac gene encod kda aa precursor serin proteas design vmtx v mimicus trypsin like proteas x examin whether vmtx also involv matur vmh vmtx isol cultur supernat v mimicus strain nre metalloproteas negat mutant construct strain es concret cultur supernat fraction satur ammonium sulfat subject affin column chromatographi use hitrap benzamidin ff column analysi n termin amino acid sequenc protein obtain vmtx prepar indic kda protein activ vmtx consist aa ile ser vmtx prepar found activ pro vmh generat kda protein addit treatment vmtx prepar serin proteas inhibitor leupeptin phenylmethylsulfonyl fluorid signific suppress activ hydrolyz specif peptid substrat synthes kda toxin find indic vmtx second proteas mediat matur vmh
|
D006460;D014733
|
T123;T007
|
36,271,935
|
immunogen third dose bntb covid vaccin patient cll effect treatment select patient chronic lymphocyt leukemia cll show suboptim respons vaccin sar cov shown though booster dose bntb vaccin may lead signific increas seroconvers rate immunocompromis patient conduct prospect non intervent studi evalu immunogen third dose bntb vaccin adult patient cll sera test first second third dose anti sar cov receptor bind domain rbd spike protein igg anti rbd thirti nine patient cll includ studi seroconvers rate increas third dose third dose higher treatment nave patient versus activ treat patient p one patient achiev seroconvers second dose retain third eight patient achiev seroconvers second dose third moreov patient activ treat venetoclax higher seroconvers rate treat ibrutinib versus p studi confirm benefici effect third dose bntb vaccin seroconvers rate patient cll result also strong suggest use venetoclax correl higher immunogenicityseroconvers rate ibrutinib find report anoth studi treatment strategi chang pandem favor use venetoclax may suggest base result although result valid larger studi
|
D015451;D000086382
|
T047;T191;T067
|
36,271,888
|
ev add databas ev associ dna human liquid biopsi sampl extracellular vesicl ev play key role cellular communic physiolog condit patholog cancer emerg evid shown ev activ carrier molecular cargo eg protein nucleic acid power sourc biomark target recent studi ev associ dna ev dna human biofluid generat larg amount data current databas catalogu inform ev dna fill gap manual curat databas ev dna data deriv human biofluid liquid biopsi vitro studi call extracellular vesicl associ dna databas ev add databas contain valid experiment detail data extract peer review publish literatur easili queri search ev isol method character ev dna isol techniqu qualiti valid dna fragment size volum start materi gene name diseas context current databas contain sampl repres diseas differ type ev isol techniqu appli eight differ human biofluid eg blood saliva addit ev add encompass ev dna data repres whole genom specif includ oncogen kras egfr braf myc mitochondri dna mtdna ev add data metric system also integr assign complianc score misev guidelin base experiment paramet report studi current avail databas document presenc protein lipid rna metabolit ev eg vesiclepedia exocarta exobcd evpedia ev track best knowledg ev add first kind compil avail ev dna dataset deriv human biofluid sampl believ databas provid import refer resourc ev dna base liquid biopsi research serv learn tool showcas latest develop ev dna field ev add updat year newli publish ev dna data becom avail freeli avail wwwevdnadatabasecom
|
D000067128;D009696
|
T026;T123;T114
|
36,271,885
|
provir role human respiratori epitheli cell deriv small extracellular vesicl sar cov infect small extracellular vesicl sev nm diamet vesicl delimit lipid bilay form within endosom network deriv plasma membran secret various biolog fluid includ airway nasal mucus goal work understand role sev present mucus mu sev produc human nasal epitheli cell hnec sar cov infect show uninfect hnec produc mu sev contain sar cov receptor ace activ proteas tmprss mu sev cleav prefus viral spike protein ss boundari result higher proport prefus protein expos receptor bind domain open conform therebi facilit receptor bind cell surfac show role nasal mu sev complet prefus spike prime perform intracellular furin viral egress infect cell effect mediat vesicular tmprss activ render sar cov virion prone entri target cell use earli tmprss depend pathway instead late cathepsin depend rout result indic prefus spike prime mu sev nasal caviti play role viral tropism also show nasal mucus protect sar cov infect instead facilit
|
D000086382;D000067128
|
T026;T047;T067
|
36,271,851
|
retrograd type aortic dissect differ evil retrograd type aortic dissect rtaad spontan secondari instrument descend thoraco abdomin aorta anatom differ compar antegrad type aortic dissect impact manag prognosi treatment standard report approach spontan rtaad institut n mean age year male aortic valv coronari arteri supra aortic trunk spare dissect case distal extens iliac common lower limb malperfus present case ascend aorta dilat present case emerg surgeri archfet replac offer patient patient receiv limit proxim aortic repair patient treat conserv overal mortal limit proxim repair receiv archfet advoc aggress treatment rtaad exclud primari entri tear prevent immedi mid term complic
|
D019917;D000784;D017545
|
T061;T047;T046
|
36,271,847
|
laboratori signatur differenti toler hypotherm circulatori arrest acut type aortic dissect surgeri goal investig whether laboratori signatur admiss could use identifi risk stratif differ toler hypotherm circulatori arrest acut type aortic dissect surgeri
|
D000784;D006323;D017545
|
T047;T046
|
36,271,846
|
pegyl phosphatidylglyceroldocosahexaeno acid hexosom tocopheryl succin poli ethylen glycol induc morpholog transform vesicl prolong circul time consid broad therapeut potenti omega polyunsatur fatti acid docosahexaeno acid dha studi effect pegyl dha incorpor hexosom physicochem characterist biodistribut follow intraven inject mice hexosom form phosphatidylglycerol dha weight ratio pegyl achiev incorpor either tocopheryl succin poli ethylen glycol tpgs mpeg distearoyl sn glycero phosphoethanolamin n methoxi poli ethylen glycol dspe mpeg concentr wt nanoparticl track analysi synchrotron small angl scatter cryo transmiss electron microscopi employ character nanodispers result show pegyl lipid induc structur transit invers hexagon h phase insid nanoparticl hexosom lamellar l phase vesicl also follow effect mous plasma nanodispers size distribut number morpholog chang brought plasma constitu could regul vivo perform intraven inject nanodispers compar biodistribut studi fluoresc label nanodispers equival quantum yield inject intraven healthi mice tpgs mpeg induc vesicl effect avoid hepatosplen clearanc earli time point orthotop xenograft murin model glioblastoma tpgs mpeg induc vesicl also show improv local brain compar nativ hexosom discuss observ implic futur design inject lyotrop nonlamellar liquid crystallin drug deliveri nanosystem therapeut intervent brain liver diseas
|
D004281;D053758
|
T123;T121;T073;T109
|
36,271,841
|
target dna repair enhanc efficaci sorafenib hepatocellular carcinoma multityrosin kinas inhibitor sorafenib remain import system treatment option hepatocellular carcinoma hcc signal pathway target sorafenib involv checkpoint dna repair respons rad candid protein aim evalu effect human rad inhibitor b combin sorafenib human hcc cell impact rad express hcc patient surviv evalu silico approach use human protein atlas dataset cell viabil huh akh akh p assess neutral red assay measur cytotox quantifi loss membran integr lactat dehydrogenas releas also employ coloni format assay hang drop method assess clonogen invas abil hcc cell line upon sorafenib b treatment cell cycl distribut character apoptosi evalu flow cytometri silico approach reveal hcc patient higher express rad messeng rna signific shorter overal surviv rad inhibitor b alon combin sorafenib signific reduc viabil coloni format abil invas capac hcc cell cell cycl analysi reveal combin agent reduc proport cell gm phase lead accumul subg phase rad inhibitor b seem promis agent hcc treatment enhanc antitumor effect sorafenib vitro
|
D006528;D008113;D000970
|
T121;T191;T109
|
36,271,816
|
studi hla class ii loci reveal dqb risk factor asthma pakistani popul asthma chronic inflammatori disord lung airway typic result combin multipl environment genet factor human leucocyt antigen hla region chromosom p encod high polymorph loci human genom encod gene central role immun function hla loci strong associ various immun mediat diseas autoimmun allergi infect allel hla class ii gene drb dqb key genet marker develop asthma extens studi differ ethnic world popul howev genet screen hla class ii allel haplotyp pakistani asthmat studi far aim present studi screen hla class ii drb dqb allel asthma case control pakistani popul seven hundr two healthi control asthma patient genotyp hla class ii sequenc specif polymeras chain reaction assay hla drb hla dqb allel haplotyp frequenc calcul risk protect associ asthma determin two locus haplotyp drb dqb allel imput use arlequin version softwar signal associ asthma stronger dqb locus compar drb hla dqb odd ratio confid interv ci signific associ increas risk asthma haplotyp compris allel drb dqb ci contrast dqb ci dqb ci emerg protect allel asthma data conclud hla dqb allel risk allel asthma wherea two dqb allel dqb dqb associ asthma protect find highlight promin role hla dqb allel asthma pathogenesi studi pakistani case studi especi larger studi cohort need confirm util hla dqb predict marker
|
D001249
|
T047
|
36,271,797
|
molecular basi lethal cross talk two unrel bacteri transcript factor regulatori protein restrict modif system repressor defect prophag bacteri gene express depend effici function global transcript network howev interconnect orchestr reli main action individu dna bind protein call transcript factor tfs tfs interact specif target site also secondari target site vari promiscu clear yet mechan govern interact secondari site rewir affect overal regulatori network could clear constrain horizont gene transfer show molecular mechan one target interact two unrel tfs escherichia coli c regulatori protein type ii restrict modif system racr repressor defect prophag reveal c protein interfer racr repressor express result derepress toxic ydat protein result also provid novel insight regul racr ydast operon map c regul interact specif target site also visual c protein dynam reveal intrigu differ singl molecul dynam differ genet context result demonstr appar exampl horizont gene transfer lead adventiti tf cross talk negat effect recipi viabil broad studi repres experiment access model regulatori constraint horizont gene transfer
|
D014157;D015280
|
T123;T126;T116
|
36,271,789
|
molecular basi cyclic tetra oligoadenyl process small standalon crispr cas ring nucleas standalon ring nucleas crispr ancillari protein downregul immun respons type iii crispr cas system cleav cyclic oligoadenyl ca second messeng two gene function found within sulfolobus islandicus sis genom code long polypeptid compos carf domain fuse hth domain short polypeptid constitut carf domain residu c termin insert determin structur apo substrat bound state sis enzym reveal insert c termin region carf domain play key role close catalyt site upon substrat bind analysi reveal key residu sis cleavag coupl activ site close posit proceed ca phosphodiest hydrolysi time cours comparison ca cleavag short sis long ring nucleas sis show slower cleavag kinet former suggest combin two type enzym function genom could evolutionari strategi regul level second messeng differ infect scenario
|
D064130
|
T123;T116
|
36,271,755
|
network effect brain lesion caus central poststrok pain studi undertaken test whether lesion caus central poststrok pain cpsp associ specif connect profil whether connect associ metabol chang whether network align neuromodul target pain
|
D063132;D009437;D009422
|
T184;T047;T017;T091
|
36,271,736
|
mechan chlorat toxic resist pseudomona aeruginosa pseudomona aeruginosa opportunist bacteri pathogen often encount hypoxicanox environ within host increas toler mani convent antibiot toward identifi novel treatment explor therapeut potenti chlorat pro drug kill hypoxicanox antibiot toler p aeruginosa popul chlorat relat nontox enzymat reduc toxic oxid agent chlorit hypox induc nitrat reductas better assess chlorat therapeut potenti investig mechan chlorat toxic resist p aeruginosa use transposon mutagenesi identifi gene alter p aeruginosa fit chlorat treatment find methionin sulfoxid reductas msr repair oxid methionin residu support surviv chlorat stress chlorat treatment lead proteom wide methionin oxid exacerb msramsrb strain respons chlorat p aeruginosa upregul protein involv wide rang function includ metabol dna replicationrepair protein repair transcript translat newli synthes protein particular vulner methionin oxid addit exogen methionin partial rescu p aeruginosa surviv chlorat treatment suggest widespread methionin oxid contribut death final found mutat decreas nitrat reductas activ common mechan chlorat resist
|
D002704;D011355
|
T120;T121;T197
|
36,271,735
|
methionin oxid anaerob condit escherichia coli repair oxid target macromolecul central mechan necessari live organ adapt oxid stress reactiv oxygen chlorin speci preferenti oxid sulfur contain amino acid protein among amino acid methionin convert methionin sulfoxid post translat oxid revers methionin sulfoxid reductas msr enzym gram negat bacteria antioxid msrpq system involv repair periplasm oxid protein surpris studi observ escherichia coli msrpq high express absenc oxygen demonstr anaerob induct msrpq due chlorat clo contamin casamino acid molecular investig led us determin reduct chlorat toxic oxid agent chlorit clo three nitrat reductas nara narz nap led methionin oxid periplasm protein respons stress e coli hprsr two compon system activ lead product msrpq studi therefor support idea methionin oxid protein part chlorat toxic msrpq consid anti chloratechlorit defens system bacteria final studi challeng tradit view absenc met oxid anaerobiosi
|
D004926;D033903
|
T123;T007;T116
|
36,271,686
|
get clock back feet target circadian clock treat osteoarthr grow evid suggest circadian clock dysfunct may contribut patholog osteoarthr issu et al use vivo human deriv osteoarthr model demonstr therapeut potenti pharmacolog manipul compon cartilag circadian clock author provid import proof principl support circadian clock target therapi treatment option osteoarthr comment https doiorgfeb
|
D057906;D010003
|
T047;T040
|
36,271,674
|
chitotriosidas biomark adult onset leukoencephalopathi axon spheroid pigment glia adult onset leukoencephalopathi axon spheroid pigment glia alsp lead rapid progress dementia caus mutat gene csfr neurodegener driven dysfunct microglia predomin cell type express csfr brain assess chitotriosidas enzym secret microglia serum cerebrospin fluid patient alsp chitotriosidas activ high increas cerebrospin fluid patient correl invers diseas durat interest presymptomat csfr mutat carrier show elev chitotriosidas level make chitotriosidas promis new biomark diseas activ rare diseas
|
D056784
|
T047
|
36,271,631
|
effect chromium vi toxic benzo z pyren hbe cell contamin human habitat complex mixtur heavi metal polycycl aromat hydrocarbon pah import environment industri health problem hexaval chromium cr vi benzo pyren b p typic two respect recent decad great deal research focus carcinogen mechan action howev studi conduct evalu combin effect human cell import implic overal understand toxic interact current studi combin toxic effect b p cr vi studi human bronchial epitheli cell hbe measur genotox activ epigenet chang two toxic alon combin cell analyz differ singl combin toxic result show b p caus dna damag hbe cell concentr depend manner presenc cr vi show sharp decreas dna damag inhibit express gene relat base excis repair induc b p addit cr vi also reduc b p trigger epigenet chang hbe cell conclus combin effect b p cr vi hbe cell less toxic singl b p exposur indic combin toxic two toxic partial antagonist research requir explor mechan antagon
|
D001564;D002857
|
T121;T196;T131;T109
|
36,271,607
|
congenit esophag stenosi caus tracheobronchi remnant case report describ case congenit esophag stenosi patient underw ineffect balloon dilat twice eventu requir surgeri case initi misdiagnos achalasia patholog find reveal tracheobronchi remnant tbrs muscular layer strictur esophag tissu tbr strictur locat middl lower third esophagus esophagographi main examin method esophag strictur appear rat tail sign key diagnost indic endoscop ultrasonographi reveal hypoecho cartilagin structur gold standard tbr treatment includ esophag strictur resect end end esophag anastomosi construct structur prevent reflux present endoscop longitudin resect transvers anastomosi anterior esophag wall partial cartilag resect without pyloroplasti novel practic tbr procedur avoid complic patient congenit esophag stenosi prompt treat surgic balloon dilat ineffect
|
D004940;D013505;D005764
|
T061;T047
|
36,271,606
|
associ parafibromin express presenc brown tumor jaw tumor patient primari hyperparathyroid seri case review literatur background brown jaw tumor rare entiti poor understood etiolog regard end stage bone remodel patient long last chronic hyperparathyroid jaw tumor main diagnos jaw tumor syndrom hpt jt syndrom caus mutat cdc gene encod parafibromin tumor suppress protein aim work present case patient genet mutat cdc gene clinic present coexist unusu set yet describ case report present case patient primari hyperparathyroid three diagnos brown tumor locat long bone rib iliac shoulder brown jaw tumor express parafibromin affect parathyroid tissu analyz patient without posit parafibromin stain search cdc mutat use next generat sequenc parafibromin stain posit patient brown tumor negat individu brown tumor brown jaw tumor cdc mutat detect two third patient negat stain parafibromin brown tumor men mutat found patient brown tumor posit stain parafibromin conclus patient hyperparathyroid coexist brown tumor jaw tumor might decreas express parafibromin parathyroid adenoma tissu might caus cdc mutat suggest genet predisposit research much larger studi group need
|
D049950;D007573;D010282;D005350
|
T047;T191
|
36,271,599
|
fast blood glucos predictor progress infarct men acut ischem stroke blood glucos relat earli neurolog deterior acut ischem stroke multipl mechan involv earli neurolog deterior progress infarct studi aim determin whether fast blood glucos fbg independ predictor progress infarct
|
D000083242;D006943;D020521
|
T033;T047
|
36,271,588
|
advanc previous two decad understand post translat modif function drug perspect argbp famili member arginin kinas bind protein argbp adapt protein belong sorbin homolog soho famili soho famili also includ c cbl associ protein cap vinexin share structur function similar argbp howev role soho famili protein cell signal drug resist metabol diseas especi cancer fulli understood herein summar structur soho famili protein post translat modif comprehens network cellular pathway regul protein emphasi argbp also discuss relev soho famili protein lipid raft distribut extracellular matrix associ microenviron drug discoveri review provid insight possibl target argbp soho famili protein drug use preclin trial
|
D001122
|
T126;T116
|
36,271,587
|
histon deacetylas inhibitor enhanc oncolyt herp simplex virus therapi malign meningioma approxim meningioma benign higher grade tend relaps surgeri radiat therapi malign anaplast meningioma mm minor subset high grade meningioma lethal effect treatment option current oncolyt herp simplex virus ohsv power anti cancer modal induc direct cell death anti tumor immun shown activ preclin model mm howev clinic meaning efficaci like entail ration mechanist combin approach show epigenom modul histon deacetylas inhibitor hdaci increas anti cancer effect ohsv human mm model iomm lee nf wild type ch nf mutant minim toxic sub micromolar concentr pan hdaci trichostatin panobinostat substant increas infect spread ohsv g within mm cell vitro result enhanc ohsv mediat kill target cell infect low multipl infect moi transcriptom analysi identifi select alter mrna process splice modul might underli potent anti mm effect combin hdaci ohsv vivo hdaci treatment increas intratumor ohsv replic boost capac ohsv control growth human mm xenograft thus work support translat develop combin approach employ hdaci ohsv treatment mm
|
D008579;D006561;D008577
|
T047;T191
|
36,271,586
|
lipid polym nanocarri platform enabl x ray induc photodynam therapi human colorect cancer cell studi brought togeth x ray induc photodynam therapi x pdt chemo drug fu treatment colorect cancer cell achiev develop lipid polym hybrid nanoparticl deliveri system fa lpnps vp fu prepar incorpor photosensit verteporfin chemotherapi drug fu target moieti folic acid one platform averag size nanoparticl around nm low polydispers expos clinic dose gy x ray radiat fa lpnps vp fu generat suffici amount reactiv oxygen speci trigger apoptosi necrosi pathway cancer cell combin x pdt chemo drug strategi effect inhibit cancer cell growth prolifer cell cycl analys reveal treatment induc gm phase arrest hct cell result indic combin treatment provid better antitumour effect colorect cancer cell modal alon may offer novel approach effect colorect cancer treatment reduc target effect drug toxic
|
D010778;D053758;D000970;D015179
|
T061;T121;T073;T109;T191
|
36,271,585
|
acid sens ion channel potenti therapeut target tumor acid extracellular ph major characterist tumor tissu studi suggest local ph valu malign tumor tissu acid sens ion channel asic proton gate cation channel activ low extracellular ph recent increas number studi suggest asic involv differ kind tumor play import role occurr develop tumor therefor review summar studi involv asic tumor discuss effect mechan asic numer relat tumor provid new perspect tumor therapeut target
|
D062565;D009369
|
T123;T191;T116
|
36,271,584
|
si wu tang amelior bile duct ligat induc liver fibrosi via modul immun environ si wu tang swt tradit chines medicin formula first record tang dynasti report allevi gynecolog liver diseas preliminarili demonstr swt could improv liver fibrosi via modul intestin microbiota littl known mechan link therapeut effect reshap immun microenviron within fibrot liver thus establish bile duct ligat bdl induc liver fibrosi murin model evalu hepatoprotect effect potenti mechan swt high perform liquid chromatographi rna sequenc molecular biolog techniqu also perform studi data demonstr swt signific improv bdl induc liver fibrosi inflammatori respons inhibit express gene associ extracellular matrix synthesi degrad combin analysi immun cell infiltr gene set enrich analysi gsea found swt remark repair unbalanc immun microenviron modul biolog function differ immun cell especi macrophag neutrophil cd cell addit swt signific inhibit activ like macrophag reduc releas profibrot cytokin prevent activ neutrophil suppress neutrophil extracellular trap format swt also effici promot apoptosi activ hepat stellat cell via fasfasl signal pathway might mediat cd tissu resid memori cell conclus research unravel intric mechan under hepatoprotect activ swt liver fibrosi also provid novel therapeut strategi treatment liver fibrosi relat complic
|
D018414;D008103
|
T047;T025
|
36,271,583
|
skelet muscl mitochondri remodel heart failur updat mechan therapeut opportun patient heart failur hf usual present skelet muscl diseas vari sever rang earli fatigu exercis sarcopenia sarcopen obes cachexia frailti signific predictor hf prognosi abnorm mitochondri metabol identifi one earliest sign skelet muscl injuri hf associ patholog alter muscl manifest muscl wast myocyt atrophi apoptosi fiber type shift impair contractil coupl muscl fat infiltr review updat evid skelet muscl mitochondri remodel hf patient anim model includ impair mitochondri ultrastructur oxid metabol electron transport chain etc phosphoryl apparatus phosphotransf system qualiti control also focus molecular regulatori mechan upstream mitochondria includ circul factor eg raa tnf il igf gh ghrelin adiponectin molecular signal within myocyt eg pgc ppar ampk sirt ros murf besid therapi target signal pathway mention adiporon elamipretid summar potenti pharmacolog approach like inhibitor sodium glucos cotransport sglt dipeptidyl peptidas dpp well natur product may benefici effect improv skelet muscl mitochondri function hf target myocyt mitochondri biogenesi oxid metabol oxid phosphoryl reduct oxid stress injuri promis futur opportun prevent manag skelet muscl myopathi hf
|
D006333;D055948;D001688
|
T121;T123;T047;T046
|
36,271,582
|
geniposid amelior glucocorticoid induc osteoblast apoptosi activ autophagi long term exposur glucocorticoid gc contribut develop osteoporosi op correl risk fractur patholog gc induc bone loss associ osteoblast apoptosi geniposid gen natur occur compound deriv eucommia ulmoid report amelior dexamethason dex induc op previous studi show gen exhibit protect activ dex induc op attenu endoplasm reticulum stress decreas apoptosi osteoblast howev molecular mechan gen inhibit dex induc osteoblast apoptosi still need elucid articl molecular target network gen op screen found gen might interact op mediat pikakt pathway upstream factor regul autophagi gen exhibit protect activ dex induc apoptosi activ autophagi vivo vitro blockag autophagi activ pikaktmtor pathway inhibit glp r activ could elimin protect effect gen dex induc apoptosi collect gen amelior dex induc osteoblast apoptosi activ autophagi glp rpikaktmtor pathway
|
D005938;D010024
|
T125;T047;T039;T109
|
36,271,581
|
gut microbiota new insight lung diseas human gut microbiota complex ecosystem involv metabol immun health host microbiom play key role develop host innat adapt immun system immun system orchestr mainten host microb symbiosi lung diseas usual accompani dysbiosi intestin flora immun inflammatori respons intestin flora metabolit direct indirect involv immun regul host lung diseas howev exact mechan action gut lung axi crosstalk remain unclear review aim summar latest advanc gut microbiota metabolit typic lung diseas pulmonari hypertens copd lung cancer especi covid problem troubl world also discuss moreov concentr action mechan identifi gut microbiota metabolit specif lung diseas link among gut microbiota metabolit immun regul could use breakthrough find new mechan target diseas without specif therapeut drug clinic also discuss new therapeut tool drug bacteri interact potenti therapeut applic clinic review would provid clear direct futur research gut microbiota lung diseas propos new therapeut strategi target drug bacteri interact clinic
|
D000069196;D000086382;D064307
|
T007;T032;T067;T028;T047;T001
|
36,271,580
|
comparison psychoact activ four primari areca nut alkaloid zebrafish behavior approach molecular dock areca palm nut areca catechu list one addict substanc along tobacco alcohol caffein belong famili arecacea wide use asia areca nut contain seven psychoact alkaloid howev effect alkaloid behavior rare address zebrafish therefor studi aim compar psychoact potenti advers effect four primari alkaloid arecolin arecaidin guvacin guvacolin isol areca nut zebrafish found four alkaloid induc hyperact like behavior zebrafish larva cooper result previous studi molecular dock score suggest alkaloid might bind multipl muscarin acetylcholin receptor machr various best bind mode shown accord adult zebrafish behavior test arecolin found slight increas locomotor activ caus tighten shoal format adult zebrafish meanwhil zebrafish expos arecaidin reduc aggress conspecif social interact similar arecaidin guvacolin treatment also caus abnorm zebrafish social behavior furthermor fish display abnorm exploratori behavior expos guvacolin interest alter fear respons behavior display guvacin treat fish besid lower locomotor activ base result molecular dock hypothes behavior alter might consequ interact alkaloid multipl machr nervous system summari studi found alkaloid specif affect adult zebrafish behavior
|
D001114;D000470
|
T121;T123;T109;T131;T002
|
36,271,579
|
effect sedi herba sedum sarmentosum attenu cholestasi activ farnesoid x receptor fxr mediat signal sedum sarmentosum sedi herba tradit use treat jaundic various type liver diseas studi aim clarifi anti cholestat efficaci mechan sarmentosum ethyl acet extract sdeae well screen potenti compound fxr activ sdeae effect amelior anit induc cholestasi rat evidenc amelior histopatholog liver signific decreas biochem marker alt ast alp ggt tbil dbil tba analysi bile acid profil lc ms indic sdeae decreas toxic bile acid level tca tmca ca western blot indic sdeae activ fxr associ pathway therebi upregul fxr shp bsep ugtb express downregul cypa ntcp express twenti three compound sesquiterpenoid flavonoid lignin sterol anthraquinon isol identifi sdeae compar nmr data literatur hplc profil sdeae isol compound also compar high content analysi show eight compound could activ fxr compound exhibit potent activ p molecular dock suggest main bind mode activ compound fxr hydrogen bond van der waal forc compound highest dock score activ compound fxr mediat signal valid l cell sirna regul fxr compound signific elev fxr shp bsep ugtb express reduc cypa ntcp express
|
D031963;D002779
|
T047;T002
|
36,271,578
|
transplant adipos deriv mesenchym stem cell amelior acut hepat injuri caus nonsteroid anti inflammatori drug diclofenac sodium femal rat although benefici role adipos deriv mesenchym stem cell ad mscs acut liver injuri address numer studi employ differ liver injuri induc role rat ad mscs rad mscs diclofenac sodium dic induc acut liver injuri yet clarifi
|
D045164;D059630
|
T061;T025
|
36,271,577
|
hypertens vascular cardiac remodel protect allicin spontan hypertens rat via camk nf b pathway allicin main activ compon tradit chines medicin garlic wide use treat cardiovascular diseas previous studi confirm allicin signific reduc blood pressur spontan hypertens rat shrs howev report studi effect allicin vascular cardiac remodel caus hypertens under mechan studi detail fulli elucid studi treat week old shrs allicin week week allicin shown improv vascular cardiac remodel shrs evidenc reduc cardiac left ventricular wall thick aortic vessel thick reduc prolifer cell nuclear antigen pcna smooth muscl actin sma increas express smooth muscl sm addit allicin reduc serum il il tnf level improv calcium homeostasi cardiomyocyt downregul calcium transport relat camk ii inflamm relat nf b nlrp observ smooth muscl cell cardiomyocyt thus infer allicin protect hypertens vascular cardiac remodel spontan hypertens rat inhibit activ camk ii nf b pathway studi also provid new mechanist insight anti hypertens vascular cardiac remodel effect allicin highlight therapeut potenti
|
D016328;D006973
|
T129;T047;T116
|
36,271,576
|
hoxa crucial transcript factor cancer potenti therapeut target hox gene occupi signific role embryogenesi hematopoiesi oncogenesi hoxa member cluster hox gene essenti establish skeleton normal organogenesi previous report aberr hoxa express contribut anomali dysfunct various organ well affect prolifer differenti invas apoptosi biolog process tumor cell differ cancer show downregul upregul hoxa express common strategi control hoxa downregul express may cpg island hypermethyl addit current research demonstr regulatori network hoxa connect cancer stem cell progress immun microenviron epigenet modul upstream regul dnmti retino acid may benefici anti tumor effect target hoxa summar current knowledg hoxa gene role various cancer potenti therapeut valu
|
D005801;D009369
|
T191;T028
|
36,271,575
|
protect effect thymoquinon orand thymol monosodium glutam induc attent deficithyperact disord adhd like behavior rat modul nrfho tlrnf bnlrpcaspas wnt catenin signal pathway rat model thymoquinon tq thymol prove possess posit impact human health research aim investig effect compound separ togeth attent deficithyperact disord adhd like behavior induc monosodium glutam msg rat forti male spargu dawley rat pup postnat day random alloc five group normal salin ns msg msgtq msgt msgtqt msg mgkgday tq mgkgday mgkgday oral administ week behavior test prove rat treat tq andor show improv locomotor attent cognit function compar msg group pronounc effect display combin treat group show improv msg induc aberr brain level gsh il tnf gfap glutam calcium dopamin norepinephrin wnta catenin bdnf tq andor treatment also enhanc mrna express nrf ho bcl reduc protein express tlr nfb nlrp caspas bax aif gsk compar msg group howev combin therapi show signific effect measur paramet find confirm histopatholog examin current result conclud combin therapi tq higher protect effect individu supplement msg induc adhd like behavior rat
|
D001289;D012970
|
T121;T168;T116;T048
|
36,271,574
|
therapeut efficaci scutellaria baicalensi georgi psoriasi like lesion via regul respons keratinocyt macrophag psoriasi chronic recurr skin problem affect global popul nowaday medicin may promis complet cure patient psoriasi develop pharmacoresist side effect drug due microenviron impact context skin imbal herein attempt explor pharmaceut efficaci scutellaria baicalensi baicalensi modul microenviron creat macrophag keratinocyt psoriasi result indic treatment baicalensi extract signific reduc thick epidermi attenu psoriat lesion moreov baicalensi extract obvious inhibit activ infiltr macrophag allevi inflammatori factor nuclear factor kappa light chain enhanc activ b cell nf b cyclooxygenas cox administr baicalensi extract also remark abolish oxid damag upon dna protein attribut activ nuclear factor erythroid relat factor nrf heme oxygenas ho network analysi redox proteom cytokin profil suggest baicalensi administr regul specif pathway associ oxid stress inflamm cytokin signal cascad amelior macrophag target respons subsequ arrest prolifer keratinocyt collect find highlight import baicalensi applic reprogram microenviron provid altern complementari intervent long term psoriat therapi
|
D031364;D011565
|
T047;T002
|
36,271,573
|
natur product target atr chk signal pathway cancer therapi cancer one sever medic condit world caus million death year chemotherapi radiotherapi critic treatment approach numer advers health effect furthermor resist cancer cell anticanc medic lead treatment failur rise burden cancer requir novel efficaci treatment modal natur remedi offer feasibl altern option malign contrast avail synthet medic select kill cancer cell privileg mainstream cancer treatment target therapi repres new tool potenti pursu aim discoveri innov therapi target essenti compon dna damag signal repair pathway ataxia telangiectasia mutat rad relat checkpoint kinas atr chk offer possibl signific therapeut improv oncolog activ inhibit pathway account chemoprevent chemotherapeut activ respect target pathway also aid overcom resist convent chemo radiotherapi review enlighten anticanc role natur product atr chk activ inhibit addit compound shown chemotherapeut synergist potenti use combin anticanc drug ideal review trigger interest natur product target atr chk potenti efficaci safeti cancer lessen agent
|
D001688;D009369
|
T123;T121;T191
|
36,271,572
|
effect psidium guajava l leav extract blood pressur control il product salt depend hypertens rat psidium guajava guava leav extract display anti hypertens properti mechan yet fulli understood investig whether sympathet drive immun signal mechan involv antihypertens effect guava extract model salt depend hypertens raw guava extract rpse character colorimetr uplc ms techniqu two dose rpse mgkg evalu anti hypertens effect use suspens system pse wean male wistar rat put high salt diet hsd na week receiv gavag pse last week blood pressur bp measur end treatment conscious rat neurogen pressor effect assess ganglion blockad hexamethonium autonom modul heart rate evalu spectral analysi effect oral administ pse lumbar sympathet nerv activ lsna assess anesthet rat blood il il tnf measur increas neurogen pressor effect hsd rat reduc pse mgkg mgkg pse mgkg administr anesthet rat produc greater fall bp hsd rat compar standard salt diet ssd rat pse hypotens respons elicit unproportion increas lsna hsd rat compar ssd rat pse mgkg increas plasma concentr il effect tnf il data indic antihypertens effect pse may involv autonom mechan immunomodul overexpress il salt depend hypertens rat
|
D031647;D006973
|
T168;T047;T002
|
36,271,571
|
rafoxanid sensit colorect cancer cell trail mediat apoptosi colorect cancer crc remain lead caus cancer relat death world main due lack effect treatment advanc diseas tnf relat apoptosi induc ligand trail driven cell death crucial event control tumor growth select target malign rather non transform cell howev fact cancer cell includ crc cell either intrins resist acquir resist trail repres major hurdl use trail base strategi clinic agent abl overcom crc cell resist trail thus great therapeut potenti mani research make eort identifi trail sensit anthelmint drug rafoxanid recent emerg potent anti tumor molecul dierent cancer type recent report rafoxanid restrain prolifer crc cell normal colon epitheli cell vitro preclin model mimick sporad crc find link induct endoplasm reticulum stress phenomenon involv regul various compon trail driven apoptot pathway sought determin whether rafoxanid could restor sensit crc cell trail data show rafoxanid act select trail sensit vitro syngen experiment model crc decreas level c flip survivin two key molecul confer trail resist collect data suggest rafoxanid could potenti deploy anti cancer drug combinatori approach aim overcom crc cell resist trail base therapi
|
D000970;D015179
|
T121;T191;T109
|
36,271,570
|
bromo dihydroxybenzaldehyd attenu endotheli cell injuri high glucos induc damag hyperglycemia trigger metabol inflammatori respons lead vascular inflamm consequ induc microvascular andor macrovascular diabet complic bromo dihydroxybenzaldehyd bdb marin red alga deriv bromophenol compound found divers bioactiv includ effect anti inflamm anti diabet though mechan still unclear evalu anti vasculopathi bdb explor possibl mechan involv first mtt assay use optim treatment concentr glucos bdb huvec subsequ adopt two concentr bdb verifi protect effect bdb vascular model establish huvec high glucos mm induc damag cell migrat tube format use evalu function huvec moreov relat mechan analyz assay flow cytometri elisa qpcr intracellular ros western blot present studi demonstr bdb could protect endotheli cell apoptosi caus high glucos treatment bdb also signific reduc secret inflammatori cytokin tnf il il induc high glucos also agreement decreas p protein express activ nf b regul bdb reactiv oxygen speci ros product phosphoryl protein express also regul bdb compar high glucos alon treatment furthermor bdb reserv endotheli cell function migrat tube format high glucos condit suggest bdb could potenti candid treat vascular inflamm induc hyperglycemia
|
D016328;D006943
|
T033;T129;T047;T116
|
36,271,569
|
target pharmacokinet bioinformat screen strategi reveal jak main target xin ji er kang treatment mir injuri xin ji er kang xjek tradit chines formula present excel protect effect sever heart diseas potenti compon target still unclear aim studi elucid effect compon xjek reveal potenti mechan cardioprotect effect myocardi ischemia reperfus mir injuri
|
D015428;D000470
|
T121;T123;T109;T131;T046
|
36,271,568
|
metal metal oxid deriv nanohybrid tool biomed applic nanotechnolog cover varieti scientif area includ chemistri materi scienc physic biomedicin biolog engin metal nanohybrid extraordinari properti high research comparison bulki individu nanoparticl especi metal metal oxid nanoparticl new class function nanohybrid broad intrigu physio chemic properti show applic nanosci biomed research engin inorgan nanoparticl pave essenti compon advanc nanotechnolog synthesi done various physic chemic biolog method special featur manipul nano level physiochem properti control shape size surfac function applic metal metal oxid nanohybrid discuss includ gene deliveri theranost catalysi due versatil applic nanohybrid use detect tumor cell track visual specif region diseas develop accur multifunct imag ambient data indispens futurist applic nanohybrid nhs load therapeut drug sector core shell abil releas control sequenti manner deliveri system novel nanohybrid multidimension integr mechanist properti also shown great effect environment pollut control also proteom transcriptom approach nanohybrid action mechan discuss also includ limit mnhs monh current manuscript critic review sever avail recent kind literatur potenti offer better understand metal metal oxid nanohybrid multifunct role various biomed applic
|
D010087;D053768
|
T197;T073
|
36,271,567
|
combin niclosamid current therapi overcom resist cancer new frontier old drug niclosamid drug use treat parasit infect recent studi shown niclosamid may wide rang clinic applic use treat cancer diseas howev applic also limit water solubl safeti drug resist cancer solv problem studi shown niclosamid use combin chemotherapeut drug target drug radiotherapi immunotherapi enhanc anti tumor effect review summar drug combin strategi therapeut effect niclosamid provid refer combin therapi niclosamid wider applic antitumor drug
|
D009369;D000970
|
T121;T191;T109
|
36,271,566
|
chemic fingerprint compar vitro antioxid properti biochem effect ginger bitterleaf infus botan remark pharmacolog properti includ zingib officinal rosco zingiberacea ginger gymnanthemum amygdalinum deli sch bip asteracea bitterleaf plant frequent use tea decoct studi treatment various ill thus studi investig vitro antioxid activ chemic fingerprint ginger bitter leaf infus separ combin addit assess effect tea infus rat liver kidney indic find studi show bitterleaf infus highest phenol content g gallic acid equivalentmg comparison ginger g gallic acid equivalentmg combin g gallic acid equivalentmg ginger infus highest flavonoid content g quercetin equivalentmg preced bitterleaf g quercetin equivalentmg ginger bitterleaf infus g quercetin equivalentmg furthermor result show tea infus signific effect liver function indic alt ast compar control contrast rat plasma urea signific increas group given bitterleaf combin ginger bitterleaf infus creatinin signific decreas group receiv combin form infus gc ms analysi ginger bitterleaf infus reveal n hexadecano acid oleic acid ergosterol abund bitterleaf infus time gingerol butanon hydroxi methoxyphenyl abund ginger infus togeth find evid support medicin valu plant also reinforc prospect nutriceut
|
D020939
|
T002
|
36,271,565
|
pattern immun infiltr surviv endocrin therapi treat er posit breast cancer comput studi patient tumor infiltr immun cell tiic play critic role breast cancer bc prognosi littl known regard efficaci endocrin therapi patient er posit bc divers immunolog phenotyp investig whether tiic affect surviv endocrin therapi patient differ bc molecular subtyp data gather six studi total sampl cibersortx use analyz invas immun cell subpopul use bulk gene express profil relationship immun relat metagen immun cell subset surviv distant metastasi free surviv relaps free surviv overal surviv studi use cox regress model cell proport model quartil immun score ighg lck gene activ link better prognosi among immun cell monocyt rest cd memori cell plasma cell correl prolong surviv neutrophil treg macrophag macrophag associ unfavor prognosi similar effect report lumin subtyp lumin b subtyp cell eosinophil favor prognost factor covari adjust multivari cox regress analysi reveal high proport rest cd memori cell rest dendrit cell correl good prognosi meanwhil neutrophil associ unfavor prognosi understand monocyt macrophag interact tumor microenviron may promis studi focus comprehens research cellular immun respons tumor could help facilit develop new treatment
|
D016246;D009364
|
T191;T025
|
36,271,564
|
recent advanc respiratori diseas dietari carotenoid choic therapeut group bioactiv isoprenoid pigment known carotenoid most present fruit veget carotenoid essenti prevent physiolog issu make maintain excel health easier effect function ingredi potent health promot properti wide present food link decreas preval chronic diseas includ respiratori diseas respiratori infect primari caus death life threaten condit global wreak havoc global health system peopl reli dietari sourc carotenoid reduc plethora respiratori diseas chronic obstruct pulmonari diseas copd lung cancer asthma carotenoid receiv lot interest recent sever part world due therapeut potenti alter pathogen pathway under inflammatori respiratori diseas may improv diseas control benefici health benefit review aim provid thorough understand therapeut potenti dietari carotenoid treatment respiratori diseas identifi possibl candid novel therapeut develop
|
D002338;D000975
|
T123;T121;T109;T039;T044
|
36,271,563
|
purin metabol develop osteoporosi osteoporosi common bone metabol diseas postmenopaus women diabet patient obes patient character imbal bone format resorpt current studi conduct depth research group reveal respect pathogenesi treatment measur howev caus osteoporosi patient complex usual combin multipl factor unifi pathway induc bone loss various patholog state great facilit diagnosi treatment osteoporosi purin metabol import biolog process determin genet orient function perform adequ evid confirm widespread exist purin metabol disord various type osteoporosi purin metabol play import role process bone remodel aim present studi determin chang purin metabol high risk popul various type osteoporosi pathogenesi bone loss caus abnorm purin metabol two state balanc maintain process bone remodel includ osteogenesi adipogenesi osteoblast osteoclast abnorm purin metabol induc hyperuricemia accumul reactiv oxygen speci ros monosodium urat msu ros ros induc inflamm inhibit express osteogen turnov indic promot osteoclast differenti ada adci enpp pde gene involv purin metabol strong associ bone remodel construct network purin metabol bone metabol mine core regulatori mechan contribut reveal pathogenesi optim treatment osteoporosi
|
D001862;D010024
|
T047;T042
|
36,271,562
|
genet delet hpv e oncogen effect regress hpv driven oral squamous carcinoma tumour growth major hpv oncogen e e known notorieti drive carcinogen process human papilloma virus hpv driven cancer well establish remov e dampen hpv cancer cell growth prolifer made e attract target hpv cancer semin work laboratori employ crispr edit approach delet e result effect elimin hpv cervic cancer tumour vivo also success delay hpv tumour growth vivo aurora kinas aurk inhibitor effect strong sensit presenc e unlik previous observ cervic cancer cell vitro target ee result partial kill hpv oral squamous carcinoma osc cell howev effect sustain remov e hpv osc tumour growth explor studi investig stagger combin aurora kinas inhibit use alisertib follow crispr edit e determin would lead better hpv osc kill remark genet delet e alon suffici effect regress establish hpv osc tumour vivo suggest e essenti mainten hpv osc cancer
|
D052685;D002583;D009856;D030361;D002294;D009062
|
T123;T116;T191;T005;T047
|
36,271,561
|
scutellarin amelior osteoarthr protect chondrocyt subchondr bone microstructur inactiv nf bmapk signal transduct osteoarthr oa chronic degen diseas major caus pain disabl reduc qualiti life among elder worldwid key treat earli prevent effect intervent anti inflammatori effect scutellarin scu flavonoid deriv erigeron breviscapus increas report howev mechan scu affect oa remain unclear studi aim investig therapeut effect potenti molecular mechan scu develop oa found scu inhibit interleukin il induc degrad extracellular matrix ecm cartilag nf kappabmitogen activ protein kinas nf bmapk signal pathway addit vivo data show scu signific reduc cartilag damag destabil medial meniscus dmm mous model ovariectomi ovx induc subchondr bone loss cartilag degener mice summari data show scu expect becom potenti effect candid treatment strategi oa
|
D019902;D010003
|
T047;T025
|
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