PMID
int64 35.7M
36.4M
| Title/Abstract
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36,266,611
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patient experi non invas prenat test nipt primari screen aneuploidi netherland non invas prenat test nipt screen method trisomi chromosom abnorm adopt wide across globe howev mani clinic valid studi perform less known regard patient experi nipt studi explor individu experi nipt pre post test set nipt broad avail primari screen method option report beyond common trisomi
|
D014314;D011296
|
T060;T049;T019
|
36,266,610
|
maintain healthi sleep pattern frailti transit prospect chines studi littl known effect maintain healthi sleep pattern frailti transit
|
D000073496;D007319
|
T184;T033;T047;T046;T048
|
36,266,609
|
integr analys immun relat biomark associ mechan coronari heart diseas various studi show effect immun activ pro atherogen coronari heart diseas chd therefor consid autoimmun diseas studi aim identifi potenti immun relat biomark pathway potenti regulatori network under chd differenti express gene deg chd control sampl determin analyz gse gse overlap differenti express immun relat gene de irg chd identifi analyz immport databas two geo databas total de irg identifi subsequ comprehens enrich analys suggest de irg enrich immun relat pathway includ autoimmun thyroid diseas intestin immun network iga product downstream signal event b cell receptor signatur de irg valid use extern independ dataset gse auc furthermor conduct protein protein interact network analysi identifi eight hub gene enrich regul defens respons nf b signal pathway regul jnk cascad regul cytokin product moreov network mirna mrnas transcript factor tfs mrna under integr data establish involv eight mirna tf target hub gene ultim snps mirna mediat gene network identifi screen potenti immun relat gene chd construct mirna mrna tf snp mirna network provid inspir insight occurr molecular mechan chd also lay foundat target potenti biomark use immunotherapi understand molecular mechan chd
|
D035683;D003327
|
T123;T047;T114
|
36,266,608
|
gothenburg empower scale ges psychometr properti measur invari adult congenit heart diseas belgium norway south korea patient empower associ improv differ patient report clinic outcom howev despit wide research high qualiti theoret substanti diseas generic measur patient empower lack good instrument avail report import psychometr properti includ measur invari aim studi assess psychometr properti item gothenburg empower scale ges particular focus measur invari ges across individu three countri
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D011788;D006330
|
T078;T019
|
36,266,606
|
real life evalu multi organ effect lumacaftorivacaftor fdel homozyg cystic fibrosi patient lumacaftorivacaftor lum iva cystic fibrosi transmembran conduct regul cftr protein corrector potenti combin improv lung function reduc pulmonari exacerb pex fdel homozyg cf patient howev system effect lum iva outsid respiratori system yet thorough investig
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D003550;D065101
|
T121;T047
|
36,266,598
|
risk factor hyaluronidas express clinic immunogen recombin human hyaluronidas ph enzym enabl subcutan drug administr multipl fda approv clinic develop stage therapeut includ recombin human hyaluronidas ph rhuph facilit subcutan administr rhuph reactiv antibodi potenti interact endogen ph investig rhuph immunogen risk hyaluronidas tissu express predict b cell epitop cd cell stimul indic relat observ clinic immunogen profil clinic studi endogen hyaluronidas ph express humansmic assess revers transcriptas polymeras chain reaction rt pcr quantit rt pcr deep rna seq rhuph potenti cell epitop evalu silico confirm vitro potenti b cell epitop predict rhuph sequenc silico bind polyclon antibodi various speci test rhuph peptid microarray clinic immunogen data collect subject human adult fetal tissu previous screen rt pcr tissu type analyz deep rna seq hyaluronidas ph messeng rna express detect adult human test silico analys rhuph sequenc reveal nine cell epitop cluster immunogen potenti one cluster homolog human leukocyt antigen rhuph induc cell activ peripher blood mononuclear cell donor fifteen epitop rhuph sequenc potenti cross react b cell cumul treatment induc incid anti rhuph antibodi across clinic studi hyaluronidas ph express occur primarili adult test low cd cell activ b cell cross reactiv rhuph suggest weak rhuph immunogen potenti restrict express pattern endogen ph indic low immunogen risk subcutan rhuph
|
D006821;D018984
|
T129;T121;T126;T116
|
36,266,593
|
construct evalu hyaluron acid coat flurbiprofen layer doubl hydroxid ocular drug deliveri system studi flurbiprofen fb select model drug hyaluron acid coat flurbiprofen layer doubl hydroxid ophthalm drug deliveri system ha fb ldh design prepar system model drug flurbiprofen intercal layer doubl hydroxid coat hyaluron acid ha prolong corneal resid time increas corneal permeabl drug layer doubl hydroxid ldh prepar alcohol water coprecipit method singl factor investig optimum prepar condit obtain follow mgal ratio reaction ph hydrotherm reaction time h hydrotherm reaction temperatur c condit particl size ldh nm potenti mv relat regular crystal structur could fb intercal ldh layer prepar flurbiprofen layer doubl hydroxid fb ldh end ha fb ldh prepar stir ultrason method prescript screen molecular weight ha kda concentr ha solut mgml final particl size ha fb ldh nm potenti mv success load fb coat ha verifi xrd ftir tga tem character method result vitro stabil experi indic coat ha could signific enhanc stabil ldh presenc electrolyt vitro releas result suggest cumul releas amount fb ldh ha fb ldh within h respect show certain sustain releas effect time releas mechan fb ldh preliminarili explor vitro releas experi prove releas mechan fb ldh main ion exchang result vivo ocular irrit experi demonstr ophthalm prepar studi paper safe non irrit result tear pharmacokinet rabbit show area curv auc averag resid time mrt highest concentr c max tear ha fb ldh group time higher eye drop group separ furthermor auc ha fb ldh group time higher fb ldh group result suggest ha fb ldh could improv precorn resid time result aqueous humor pharmacokinet rabbit indic auc mrt maximum concentr c max aqueous humor ha fb ldh group time eye drop group respect addit auc mrt ha fb ldh group time fb ldh group separ mention find verifi ha fb ldh could enhanc corneal permeabl drug fluoresc substanc fluoresc isothiocyan fitc substitut fb intercal ldh vitro tissu imag studi rabbit whose result state clear fitc ldh ha fitc ldh could prolong precorn resid time drug ha fitc ldh could increas corneal permeabl drug certain extent sum ha fb ldh overcom shortcom low bioavail tradit eye drop certain degre safe effect ophthalm drug deliveri system
|
D005480
|
T121;T109
|
36,266,571
|
invers hydrid shuttl catalysi enabl stereoselect one step synthesi complex framework rapid assembl complex scaffold singl step simpl precursor identifi ideal reaction term effici sustain inde direct singl step synthesi complex alkaloid framework remain unresolv problem heart organ chemistri spite tremend progress disciplin herein present broad strategi dynam assembl ternari complex convert valuabl azabicycl scaffold base concept invers hydrid shuttl catalysi ternari complex readili construct situ three simpl precursor enabl high modular instal various substitut pattern upon subject uniqu dual catalyt system transient intermedi undergo unusu hydrid shuttl process initi hydrid donat event furthermor show combin asymmetr organocatalysi product alkaloid framework obtain excel optic puriti
|
D002384
|
T070
|
36,266,567
|
role two extracellular loop proton sens permeat human otop proton channel otopetrin otop protein recent found function proton channel otop reveal sour tast receptor mammal otop protein contain twelv transmembran segment divid structur similar n c domain mechan otop channel sens extracellular proton initi gate conduct proton channel activ remain larg elus show two extracellular loop play key role human otop channel function find residu h loop critic proton sens otop data reveal loop structur function essenti otop channel residu loop regul proton permeat pore form c domain studi shed light molecular mechan behind structur function newli identifi ion channel famili
|
D007473;D011522;D010750
|
T123;T196;T116
|
36,266,565
|
toward definit microglia heterogen high dimension singl cell analysi singl cell singl nucleus rna sequenc scsnrnaseq current wide appli explor microglia divers use scsnrnaseq provid power unbias approach deconvolv heterogen cellular popul howev scsnrnaseq analys pipelin design find heterogen inde cellular heterogen often frequent report find perspect consid ubiquit concept heterogen focus applic microglia research influenc field neuroimmunolog suggest clear understand semant biolog implic microglia heterogen essenti mitig confus among research
|
D017628;D059010
|
T059;T025
|
36,266,564
|
continu exchang nectar nutrient orient hornet coloni nutrit exchang play fundament role evolut anim societi higher anim societi adult individu food donor receiv offspr usual receiv food adult hornet wasp fierc insect hunter feed larva prey howev although adult also consum floral nectar role nectar vespid nutrit remain larg unknown provid experiment coloni orient hornet artifici nectar enrich c label amino acid found continu cycl nutrit took place nectar nutrient use exchang back forth adult larva posit continu cycl nutrient constitut mechan contribut social cohes addit experi found nectar consumpt essenti adult larval surviv suggest import wasp hornet pollin natur ecosystem
|
D057048;D014863
|
T123;T204
|
36,266,563
|
salin effect strength morpholog indic soft marin clay studi evalu strength behavior morpholog characterist lianyungang marin clay effect porewat salin soil higher salin found increas intern friction angl undrain shear strength differ undrain shear strength enlarg confin pressur increas differ stress path exhibit soil differ salin soil morpholog analysi includ scan electron microscopi sem imag pro plus ipp employ investig under mechan enhanc strength behavior soft marin clay increas salin aggreg soil fabric observ higher salin contribut enhanc strength result demonstr aggreg soil structur primari mechan respond enhanc strength behavior marin clay relat high salin quantit relationship develop strength paramet morpholog characterist soil ie area particl round particl area pore pore orient fractal dimens pore distribut form empir equat expect serv refer predict undrain behavior soft marin clay known soil index
|
D054712;D012987
|
T034;T167
|
36,266,551
|
develop valid nomogram predict overal surviv young non metastat rectal cancer patient curat resect popul base analysi studi aim establish valid nomogram predict overal surviv os young non metastat rectal cancer rc patient curat resect
|
D049451;D012004
|
T081;T170;T191
|
36,266,547
|
hypomap unifi singl cell gene express atlas murin hypothalamus hypothalamus play key role coordin fundament bodi function despit recent progress singl cell technolog unifi catalog molecular character heterogen cell type specif neuron subtyp brain region still lack present integr refer atlas hypomap murin hypothalamus consist cell abil incorpor new addit experi valid hypomap compar data collect smart seqfluidigm c bulk rna sequenc select neuron cell type differ degre cellular heterogen final via hypomap identifi class neuron express glucagon like peptid receptor glpr prepronociceptin pnoc valid use singl molecul situ hybrid collect hypomap provid unifi framework systemat function annot murin hypothalam cell type serv import platform unravel function organ hypothalam neurocircuit identifi druggabl target treat metabol disord
|
D000067757;D007031
|
T023;T192
|
36,266,544
|
bacteri hydrogen sulfid drive cryptic redox chemistri gut microbi communiti microbi biochemistri contribut dynam environ gut yet bacteri metabolit hydrogen sulfid h mechanist alter gut chemic landscap poor understood show microbi generat h drive abiot reduct azo r n n r xenobiot common found western food dye drug nonenzymat reduct azo compound demonstr escherichia coli cultur human faecal microbi communiti vivo male mice chang dietari level h xenobiot redox partner red transient decreas mous faecal sulfid level demonstr xenobiot attenu sulfid concentr allevi h accumul vivo cryptic h redox chemistri thus modul sulfur homeostasi alter chemic landscap gut contribut azo food dye drug metabol interact chemic deriv microbi communiti may key featur shape metabol gut
|
D006862;D064307
|
T032;T131;T197;T028;T130;T001
|
36,266,543
|
principl function metabol compartment metabol histor studi level whole cell whole tissu whole organ result understand compartment spatial tempor separ pathway compon shape organism metabol remain limit essenc metabol compartment fulfil three import function pillar establish uniqu chemic environ provid protect reactiv metabolit enabl regul metabol pathway howev pillar establish regul maintain cellular system level remain unclear discuss three pillar establish maintain regul within cell discuss consequ dysregul metabol compartment human diseas organell increas emerg command control centr increas understand metabol compartment reveal new aspect metabol homeostasi knowledg translat therapi treatment cancer certain neurodegen diseas
|
D053858;D015388
|
T026;T169;T044
|
36,266,542
|
innat metabol respons viral infect metabol adapt viral infect critic determin cours manifest diseas system level signific featur viral infect inflamm ensu metabol shift anabol toward catabol metabol system metabol sequela insulin resist dyslipidaemia repres long term health consequ mani infect human immunodefici virus hepat c virus sever acut respiratori syndrom coronavirus long held presumpt peripher tissu specif immun respons chief line defenc thus regul viral control incomplet review focus emerg paradigm shift propos metabol engag metabol reconfigur immun non immun cell follow virus recognit modul natur cours viral infect earli metabol footprint like influenc longer term diseas manifest infect greater appreci understand local biochem adjust peripheri tissu influenc immun ultim lead intervent curtail diseas progress identifi new improv prognost biomark
|
D000086382;D014777
|
T047;T067
|
36,266,535
|
express diverg methylalkyl coenzym reductas uncultur archaea methanogen anaerob methan oxid archaea anm import player global carbon cycl methyl coenzym reductas mcr key enzym methan metabol catalyz last step methanogenesi first step anaerob methan oxid diverg mcr mcr like gene recent identifi uncultur archaeal lineag howev assembl biochemistri mcrs uncultur archaea remain larg unknown present approach studi mcrs uncultur archaea heterolog express methanogen methanococcus maripaludi promot operon structur temperatur import determin mcr product recombin methanococc anm mcr assembl host mcr form hybrid complex wherea test anm mcr ethyl coenzym reductas form homogen complex togeth structur model suggest anm methanogen mcrs structur similar reaction direct like regul thermodynam rather intrins structur differ
|
D001105;D015080
|
T194;T121;T109
|
36,266,534
|
random doubl blind control clinic trial effect captopril telmisartan combin system inflamm patient hemodialysi evalu individu combin effect captopril telmisartan system inflamm marker hemodialysi hd patient random doubl blind control clinic trial patient hd least month arterioven fistula random alloc group captoprilplacebo n telmisartanplacebo n captopril telmisartan n placeboplacebo n month patient receiv oral drug follow captopril mgday telmisartan mgday placebo patient exclud condit drug potenti influenc inflamm clinic biochem evalu perform month serum tumor necrosi factor alpha tnf interleukin il c reactiv protein crp measur month baselin demograph clinic biochem variabl compar group baselin versus final inflammatori marker captoprilplacebo tnf versus pgml il versus pgml crp versus mgl telmisartanplacebo tnf versus pgml il versus pgml crp versus mgl captopril telmisartan tnf versus pgml il versus pgml p crp versus mgl placeboplacebo tnf versus pgml il versus pgml crp versus mgl monotherapi captopril telmisartan display trend combin treatment signific decreas serum level il remark chang tnf crp observ
|
D002216;D007249;D006435;D000077333
|
T061;T121;T116;T109;T046
|
36,266,533
|
bipolar cell target optogenet gene therapi restor parallel retin signal high level vision degener retina optogenet gene therapi restor vision clinic trial whilst current clinic approach target ganglion cell output neuron retina new molecular tool enabl effici target first order retin interneuron bipolar cell potenti restor higher qualiti vision investig retin signal behavior vision blind mice treat bipolar cell target optogenet gene therapi test tool includ medium wave opsin opto mglur two new melanopsin base chimera restor visual acuiti contrast sensit best perform opsin melanopsin mglur chimera case restor visual acuiti contrast sensit match wild type anim light respons ganglion cell robust divers recept field type infer elabor inner retin signal result highlight potenti bipolar cell target optogenet recov high level vision human patient end stage retin degener
|
D062308;D012160
|
T063;T023
|
36,266,531
|
analysi intestin morpholog incretin produc cell use tissu optic clear imag tissu optic clear permit detail evalu organ three dimension structur well individu cell tissu stain autofluoresc studi evalu intestin morpholog intestin epitheli cell iec enteroendocrin cell incretin produc cell report mice intestin imag intestin imag report mice use optic tissu clear enabl us evalu detail intestin morpholog cell number villus length crypt depth sampl diseas mous model lipopolysaccharid lps inject mice result imag use tissu optic clear studi consist imag previous report could ad new data intestin morpholog analysi incretin produc cell report mice could elucid number percentag local incretin produc cell intestin differ l cell k cell thus establish novel method intestin analysi use tissu optic clear imag evalu intestin enabl us clarifi detail intestin morpholog also precis number local iec incretin produc cell sampl
|
D054795;D008070
|
T121;T116;T109;T125;T039
|
36,266,530
|
hyperspectr imag chemic identif human inspir machin learn approach data analysi increas reli machin learn recent year sinc machin implement mathemat algorithm without know physic natur problem may accur lack flexibl move across differ domain manuscript present machin educ approach machin equip physic model univers build block unlabel dataset deriv decis criteria concept machin educ deploy identifi thin layer organ materi use hyperspectr imag hsi measur spectra form nonlinear mixtur unknown background materi target materi spectra machin educ resolv nonlinear mix identifi spectral signatur target materi input educ test machin nonlinear mix model spectra pure target materi problem invari unlabel hsi data educ machin accur general capabl outperform classic machin use educ machin number fals identifi sampl time lower classic machin probabl detect educ machin compar classic machin
|
D000081862;D000069550
|
T059;T066
|
36,266,529
|
evalu microperimetri eye cuticular drusen retin sensit may vari subtyp cuticular drusen retrospect studi includ eye patient cuticular drusen patient underw assess best correct visual acuiti bcva spectral domain optic coher tomographi sd oct color fundus photographi fluorescein angiographi fundus autofluoresc microperimetri area occupi drusen count use microperimetri cuticular drusen subtyp classifi group base sd oct find age bcva pattern standard deviat area occupi drusen pupil size fals posit rate signific differ p accord cuticular drusen type mean retin sensit mrs p mean deviat md p show margin signific differ among group subgroup analys type type cuticular drusen show signific differ md vs p mrs vs p without differ age bcva area occupi drusen p result indic depend subtyp cuticular drusen type deterior retin sensit like occur decreas vision
|
D058609;D015593
|
T060;T047
|
36,266,520
|
mettl modul chromatin transcript dynam cell fate transit transcript program play key role determin cell state time reconfigur chromatin structur attenu pluripot gene requir effici embryon stem cell esc differenti identifi mettl core n methyladenosin catalyz enzym crucial modul dynam transcript chromatin access upon esc deriv cardiac differenti genom wide analysi chromatin associ rnas reveal deplet mettl fail dramat attenu transcript pluripot gene well activ nascent cardiomyocyt specif transcript upon differenti consist atac seq analysi show loss mettl mark attenu dynam alter chromatin access promot gene bodi result reduc sensit esc chromatin structur cardiac differenti signal furthermor found mettl negat regul histon modif hkme hkme involv mettl modul dynam chromatin architectur cell state transit unexpect use chromatin associ sequenc found nuclear underw dramat increas upon differenti correl decreas chromatin access collect find reveal mettl nuclear epitranscriptom coupl chromatin state ensur transcript regul cell fate transit
|
D002843;D053595
|
T116;T025
|
36,266,515
|
preliminari experi new institut tumor board dedic patient neuroendocrin neoplasm determin decis pattern neuroendocrin neoplasm nen tumor board tb factor behind
|
D000086382;D018358;D010190
|
T047;T191;T067
|
36,266,512
|
refin stress enhanc fear learn model post traumat stress disord behavior molecular analysi post traumat stress disord ptsd debilit mental health condit current treatment long term efficaci patient clear need better understand mechan under ptsd develop new treatment approach analog trauma procedur anim stress enhanc fear learn sefl procedur use produc behavior neurobiolog chang valid model ptsd howev necess model ptsd anim requir potenti experi pain suffer consist rs reduct refin replac anim research studi aim determin whether sefl procedur refin reduc potenti anim pain suffer retain behavior neurobiolog chang show ptsd relev chang could produc behavior brain rat group rather singl hous receiv lower magnitud electr shock trauma analog session also vari number shock exposur trauma analog session find sefl suscept sefl resili popul level shock exposur greater level shock increas proport rat show sefl suscept phenotyp data demonstr sefl procedur use anim analog ptsd reduc potenti pain suffer anim variat procedur could use generat specif proport sefl suscept sefl resili anim futur studi
|
D013313
|
T048
|
36,266,510
|
essenti thrombocythaemia progress fibrot phase associ decreas jak pdl level postul chang molecular characterist malign clone abnorm activ jak stat signal respons myeloprolif neoplasm progress advanc diseas phase immun escap malign clone continu jak stat pathway activ lead enhanc activ promot cd code program death receptor ligand pd l increas pd l level immun escap mpn cell aim studi evalu pdl mrna jak mrna level molecular defin essenti thrombocythaemia et patient pts diseas progress post et myelofibrosi post et mf studi group consist et pts includ pts diagnos post et mf jakvf calr mpl mutat found pts respect copi number altern jak pdl pdcdlg pdl gene found level pd l signific higher jakvf jakwt calr mutat posit tripl negat pts pd l mrna level weak correl jakvf variant allel frequenc vaf jakvf allel mrna level total jak level post et mf pts lower et pts despit lack differ jakvf vaf addit pd l level lower post et mf detail analysi shown decreas jak pdl mrna level depend bone marrow fibrosi grade pdl express show differ relat genotyp jak haplotyp ggcc hemoglobin concentr hematocrit valu leukocyt platelet count observ drop total jak pdl level et progress post et mf may reflect chang jakvf posit clone prolif potenti pd l level relat immunosuppress effect mention hypothesi support cancer genom atlas tcga data confirm strong posit associ cd encod pd l cxcr encod cxcr csf encod csf express level recent publish result document drop cxcr level circul csf patient post et mf
|
D013920;D009196;D055728
|
T047;T191
|
36,266,495
|
comparison slaughter carcass characterist limousin charolai angus hereford beef cattl turkey slaughter carcass featur four breed name limousin li charolai ch angus hereford examin nine calv breed slaughter averag age month anim weigh slaughter slaughter weight well bodi measur anim record dismember carcass perform rest period h c slaughter weight kg respect chill carcass weight kg respect signific differ among breed dress percentag valuabl meat ratio respect carcass bone ratio respect longissimus muscl area lma cm subcutan fat thick cm respect signific differ observ among breed term characterist carcass weight highest li li ch breed higher carcass yield two breed although highest slaughter weight show lowest carcass yield whilst meat obtain li ch highest fat bone ratio determin
|
D001823;D008460
|
T168;T032
|
36,266,489
|
kcnqot promot genom wide transposon repress guid rna dna triplex hp bind transposon de repress heterochromatin reorgan dynam regul cell fate determin hallmark cellular senesc howev whether sequenc specif regul remain unknown uncov kcnqot lncrna sequenc specif hoogsteen base pair doubl strand genom dna via repeat rich region bind heterochromatin protein hp guid induc maintain epigenet silenc specif repetit dna element repress kcnqot delet repeat rich region reduc dna methyl hkme kcnqot target transposon engin fusion kcnqot ectop target guid triplex sequenc induc de novo dna methyl target site phenotyp repress kcnqot induc senesc associ heterochromatin foci transposon activ retrotransposit well cellular senesc demonstr essenti role kcnqot safeguard genom instabl senesc
|
D006570;D017394
|
T026;T123;T114
|
36,266,488
|
fructos bisphosphatas function protein phosphatas dephosphoryl histon h suppress ppar regul gene transcript tumour growth tumour cell exhibit greater metabol plastic normal cell possess select advantag surviv prolifer unclear defin mechan demonstr glucos depriv normal hepatocyt induc perk mediat fructos bisphosphatas fbp phosphoryl convert fbp tetram monom expos nuclear local signal nuclear transloc import nuclear fbp bind ppar function protein phosphatas dephosphoryl histon ht suppress ppar mediat oxid gene express contrast fbp glcnacyl overexpress link n acetylglucosamin transferas hepatocellular carcinoma cell lead inhibit fbp phosphoryl enhanc oxid tumour growth addit fbp phosphoryl invers correl oxid gene express hepatocellular carcinoma specimen patient surviv durat find highlight differenti role fbp gene regul normal tumour cell direct chromatin modul underscor inactiv protein phosphatas function tumour growth
|
D006528;D008113
|
T191
|
36,266,486
|
compar effect neutralis monoclon antibodi high risk covid patient bayesian network meta analysi purpos work review synthesis evid compar effect neutralis monoclon antibodi nmab therapi individu expos infect sar cov high risk develop sever covid outcom interest mortal healthcar utilis safeti rapid systemat review undertaken identifi synthesis relev rct evid use bayesian network meta analysi relat treatment effect individu nmab compar placebo one anoth estim pool effect nmab class compar placebo estim relat effect combin baselin natur histori model predict expect risk reduct per patient treat eight articl investig four nmab bamlanivimab bamlanivimabetesevimab casirivimabimdevimab sotrovimab identifi four therapi associ statist signific reduct hospitalis reduct relat risk absolut reduct hospitalis per patient mortal icu admiss invas ventil risk lower nmab compar placebo moder high uncertainti due small event number rate serious ae infus reaction compar nmab placebo pairwis comparison nmab typic uncertain broad compar efficaci conclus nmab effect reduc hospitalis among infect individu high risk sever covid like reduc mortal icu admiss invas ventil rate effect latter outcom uncertain widespread vaccin emerg nmab resist variant make generalis result current patient popul difficult
|
D000086382;D000074322
|
T129;T121;T116;T067;T047
|
36,266,484
|
real world select first line system therapi regimen metastat gastroenteropancreat neuroendocrin neoplasm japan novemb first edit evid base guidelin treatment gastroenteropancreat neuroendocrin neoplasm gep nen publish japan howev whether medic practition adopt first line regimen recommend metastat gep nen clinic practic yet known purpos studi identifi first line system therapi regimen select proport case adher guidelin ie number patient receiv recommend therapytot number patient combin hospit base cancer registri data insur claim equival data patient gep nen treat januari decemb extract metastat gep nen receiv system therapi proport adher guidelin calcul accord tumor classif neuroendocrin tumor net neuroendocrin carcinoma nec primari site gastrointestin pancreat hospit volum high medium low studi includ patient gep net gep nec overal guidelin adher treatment provid case gastrointestin net pancreat net gastrointestin nec pancreat nec recommend therapi gep net use patient gep nec receiv fluoropyrimidin contain chemotherapi report first describ real world select first line regimen metastat gep nen half patient receiv system therapi recommend guidelin
|
D018358;D007414;D010190;D013274;D018278;D016609
|
T191
|
36,266,475
|
contribut crisprabl dna human complex trait crispr cas power genom edit tool various speci human cell line wide use mani research area includ studi mechan target gene therapi human diseas recent develop even allow high throughput genet screen use crispr system howev due practic ethic limit human gene edit research littl known whether crispr edit dna segment could influenc human complex trait diseas investig human genom region condens differ crispr cas enzym protospac adjac motif pam found cas enzym gc rich pam could interfer genom region harbor enrich herit human complex trait diseas result link gc content across genom function genom element herit enrich human complex trait provid genet overview effect high throughput genom edit human complex trait
|
D064113;D020412
|
T045;T032;T040
|
36,266,474
|
effect light dark cycl bodi weight gain preterm infant admit neonat intens care unit continu bright light condit prematur infant subject hospit neonat intens care unit nicu deleteri effect term growth develop studi evalu benefit lightdark cycl ldc weight earli hospit discharg nicu subject recruit three particip institut mexico elig patient n prematur infant hospit low risk high risk neonat unit classifi stabl subject random experiment group n alloc ldc condit follow light dark lx control group n kept normal room light condit cbl h day main outcom weight gain effect reduc intens nocturn light develop prematur infant infant ldc gain weight earlier compar random cbl signific reduct length hospit stay result highlight prematur infant subject ldc exhibit improv physiolog develop favor earlier weight gain consequ decreas hospit stay clinicaltrialsgov id nct
|
D007363;D007235
|
T047;T073;T093
|
36,266,471
|
model gene environ interact ptsd use human neuron reveal diagnosi specif glucocorticoid induc gene express post traumat stress disord ptsd develop follow sever trauma extent genet environment risk factor contribut individu clinic outcom unknown compar transcript respons hydrocortison exposur human induc pluripot stem cell hipsc deriv glutamaterg neuron peripher blood mononuclear cell pbmcs combat veteran ptsd n hipsc n pbmc donor control n hipsc n pbmc donor neuron observ diagnosi specif glucocorticoid induc chang gene express correspond ptsd specif transcriptom pattern found human postmortem brain observ glucocorticoid hypersensit ptsd neuron identifi gene contribut ptsd depend glucocorticoid respons find evid coregul network transcript factor mediat glucocorticoid hyper respons ptsd find suggest induc neuron repres platform examin molecular mechan under ptsd identifi biomark stress respons conduct drug screen identifi new therapeut
|
D013313;D057026
|
T025;T048
|
36,266,470
|
neurotensin neuron extend amygdala control dietari choic energi homeostasi obes global pandem causal link mani life threaten diseas apart rare genet condit biolog driver over reduc activ unclear show neurotensin express neuron mous interstiti nucleus posterior limb anterior commissur ipac nucleus central extend amygdala encod dietari prefer unhealthi energi dens food optogenet activ ipac nts neuron promot obesogen behavior hedon eat modul food prefer convers acut inhibit ipac nts neuron reduc feed decreas hedon eat chronic inactiv ipac nts neuron recapitul effect reduc prefer sweet non calor tastant furthermor enhanc locomot energi expenditur result mice display long term weight loss improv metabol health protect obes thus activ singl neuron popul bidirect regul energi homeostasi find could lead new therapeut strategi prevent treat obes
|
D009496;D066274
|
T125;T121;T023;T116
|
36,266,469
|
tree speci matter forest microclim regul drought year disentangl environment driver biotic driver tree canopi consid effect buffer climat extrem mitig climat chang effect drought predict becom frequent cours climat chang might alter microclimat cool potenti tree howev understand microclim tree canopi level modul environment tree characterist interact still limit investig canopi temperatur regul five matur co occur tree speci two contrast hydrolog situat sever drought even though observ signific drought induc declin canopi cover transpir across tree speci found evid differ water use strategi tree affect cool mechan differ although larg share variat cool potenti tree explain direct indirect effect meteorolog factor identifi gradual shift import latent heat flux compon defin magnitud sensibl heat flux energi budget tree drought gain sever decreas latent heat flux approxim sap flow rate furthermor result reduc cool potenti equal tree speci canopi temperatur
|
D014197;D055864
|
T070;T002
|
36,266,468
|
mitochondri biogenesi telomer length cellular senesc parkinson diseas lewi bodi dementia progress age singl major risk factor neurodegen diseas cellular age marker parkinson diseas pd implic previous studi howev major studi investig associ individu cellular age hallmark pd joint studi associ pd three age hallmark telomer attrit mitochondri dysfunct cellular senesc blood brain tissu result show pd patient lower mitochondri dna copi longer telomer blood compar control moreov telomer length blood posit correl medic levodopa equival daili dose ledd diseas durat similar result found brain tissu patient parkinson diseas pd parkinson diseas dementia pdd dementia lewi bodi dlb show deplet mtdna copi longer telomer compar control addit patient lower mitochondri biogenesi pgc pgc higher load cellular senesc marker postmortem prefront cortex tissu dlb show highest effect among patient group result suggest mitochondri dysfunct copi number biogenesi blood might valuabl marker assess risk pd howev studi larger sampl size need evalu find
|
D010300;D020961;D003704
|
T047;T048
|
36,266,467
|
investig ionic condit sirna mediat deliveri carrier cell membran molecular dynam simul sirna new generat drug molecul new approach treat varieti diseas cancer viral infect sirna deliveri cell transloc cytoplasm main challeng clinic applic sirna lipid carrier one success carrier sirna deliveri studi investig interact sirna zwitterion bilay ion concentr lipid conjug affect dival cation mg ion could promot sirna adsorpt bilay surfac cation ion bind head group lipid groov sirna molecul form bridg sirna bilay surfac find demonstr bridg form dival ion could facilit attach sirna membran surfac show dival cation regul bridg driven membran attach seem result modul use design biomimet devic follow examin effect cation interact sirna modifi cholesterol membran surfac md simul show presenc mg electrostat vdw energi membran sirna higher compar presenc na show electrostat interact membran sirna facilit cholesterol conjug inde cation essenti creat coulomb repuls enabl membran attach studi provid import insight liposom carrier sirna deliveri could help us develop sirna base therapeut due coronavirus pandem outbreak result may shed light new approach treat diseas molecular detail
|
D056004;D008051
|
T026;T066;T044
|
36,266,465
|
improv alphafold model implicit experiment inform machin learn predict algorithm alphafold rosettafold creat remark accur protein model model usual region predict low confid poor accuraci hypothes implicit includ new experiment inform densiti map greater portion model could predict accur might synergist improv part model fulli address either machin learn experi alon iter procedur develop alphafold model automat rebuilt basi experiment densiti map rebuilt model use templat new alphafold predict show includ experiment inform improv predict beyond improv obtain simpl rebuild guid experiment data procedur alphafold model densiti incorpor autom procedur interpret crystallograph electron cryo microscopi map
|
D011506;D000465
|
T123;T170;T116
|
36,266,464
|
commens oral microbiota impact ulcer oral mucos clinic cours allogen stem cell transplant recipi oral mucos om complex acut cytotox antineoplast treatment affect patient undergo hematopoiet stem cell transplant om associ prolong hospit increas extens pharmacotherapi need parenter nutrit elev treatment cost om onset relat mucos microenviron status particular role microbiota driven inflamm aim investig whether oral mucosa microbiota associ clinic cours om patient undergo allogen hematopoiet stem cell transplant collect oral mucosa sampl patient analyz oral mucosa microbiota rrna sequenc total patient develop ulcer om observ specif taxa associ oral mucos grade time oral mucos heal porphyromona relat abund precondit posit correl ulcer om grade spearman p higher lactobacillus relat abund ulcer om onset associ shorten ulcer om durat p addit generat machin learn base bacteri signatur use pre treatment microbi profil predict whether patient develop om treatment find suggest research focus host microbiom interact better prevent treat om
|
D013280;D018380;D064307;D013281
|
T061;T032;T028;T047;T001
|
36,266,463
|
automat deep learn base consolidationcollaps classif lung ultrasound imag covid induc pneumonia autom deep learn base approach identifi consolidationcollaps lus imag aid identif late stage covid induc pneumonia consolidationcollaps one possibl associ patholog common challeng train model annot frame ultrasound video requir high label effort effort practic becom prohibit larg ultrasound dataset understand impact various degre label precis compar label strategi train fulli supervis model frame base method higher label effort inaccur supervis model video base method lower label effort yield binari predict lus video frame frame level moreov introduc novel sampl quaternari method random sampl lus video frame subsequ assign ordin categor label frame video base fraction posit annot sampl method outperform inaccur supervis video base method surpris supervis frame base approach respect metric precis recal area curv pr auc f score despit form inaccur learn argu video base method robust respect label nois mitig overfit manner similar label smooth algorithm train use ten fold cross valid result pr auc score accuraci efficaci classifi use sampl quaternari method signific lower label effort must verifi larger consolidationcollaps dataset propos classifi use sampl quaternari video base method clinic compar train expert perform
|
D000077321;D000086382
|
T047;T067;T066
|
36,266,462
|
bdnftrkb axi provok emt progress induc cell aggress via crosstalk cancer associ fibroblast human parotid gland cancer parotid gland cancer pgc rare malign molecular characterist remain poor understood preclud develop effect drug therapi given poor prognosi mani human cancer tropomyosin receptor kinas b trkb high express investig involv brain deriv neurotroph factor bdnf trkb pathway pgc cell use clinic specimen observ upregul trkb bdnf primari cultur system patient deriv pgc cell cancer associ fibroblast caf pgc cell co cultur caf exhibit signific upregul bdnf epitheli mesenchym transit emt similar result observ pgc cell treat condit medium co cultur pgc cell caf administr trk inhibitor suppress bdnf induc cell migrat pgc cell immunohistochem clinicopatholog analys tumor patient pgc reveal bdnf trkb high express tumor cell stromal cell caf trkb express level pgc cell signific correl aggress featur includ vascular invas nodal metastasi poor prognosi collect data suggest bdnftrkb pathway regul pgc cell aggress via crosstalk caf potenti therapeut target pgc harbor invas metastat featur
|
D019208;D000072645;D020813;D012468
|
T123;T116;T025;T192;T191;T126
|
36,266,461
|
multiom analysi reveal hepatocyt nuclear factor regul axon guidanc gene develop mous kidney transcript factor hepatocyt nuclear factor hnf essenti normal develop kidney epitheli organ develop mous kidney hnf requir differenti pattern immatur nephron branch morphogenesi ureter bud ub use chip sequenc chip seq rna sequenc rna seq identifi gene regul hnf embryon mous kidney chip seq reveal hnf bind site chromatin e mous kidney comparison previous atac seq histon modif studi show hnf bind peak coloc open chromatin epigenet mark transcript activ hk acetyl hk trimethyl hk monomethyl indic bind site function investig relationship hnf bind hnf depend gene regul rna seq perform ub cell purifi wild type hnf mutant embryon kidney total gene show reduc express hnf defici ub cell gene contain nearbi hnf bind site indic direct activ hnf convers hnf direct repress express gene ub comparison snatac seq analysi ub deriv cell show hnf depend activ repress correl chromatin access pathway analysi reveal hnf bind near axon guidanc gene develop kidney rna seq analysi show nrp semac semad semaa slit activ hnf wherea efna epha epha epha ntn plxna semaa semab slit srgap uncc uncd repress hnf rnascop situ hybrid show nrp semac semad semaa slit express wild type ub dysregul hnf mutant ub studi show hnf direct regul express multipl axon guidanc gene develop mous kidney dysregul axon guidanc gene may underli kidney defect hnf mutant mice
|
D000071437;D051539
|
T123;T116;T043
|
36,266,456
|
chill coma recoveri cerat capitata adult across northern hemispher mediterranean fruit fli cerat capitata diptera tephritida invas pest current expand geograph distribut mediterranean coast temper area europ given low temperatur primari determin insect speci rang boundari especi northern hemispher pronounc season use chill coma recoveri time assess latitudin cline basal chill toler c capitata adult select six popul obtain area broad climat variabl base main bioclimat variabl temperatur precipit span latitudin rang middl east central europ adult expos c h time regain typic stand posit fli c record post stress surviv period day also record result reveal adult israel austria less chill toler greec result curvilinear trend latitud analysi macroclimat condit reveal combin effect latitud proxi photoperiod macroclimat condit chill coma recoveri time nonetheless deleteri effect post recoveri surviv except fli obtain northern point vienna austria overal seem evolutionari pattern basal chill coma recoveri time c capitata adult driven main local climat variabl
|
D033622;D033621
|
T204
|
36,266,455
|
comprehens evalu polygen score genotyp imput perform human snp array divers popul regardless overwhelm use next generat sequenc technolog microarray base genotyp combin imput untyp variant remain cost effect mean interrog genet variat across human genom technolog wide use genom wide associ studi gwas bio bank scale recent polygen score pgs analysi predict stratifi diseas risk last decad human genotyp array undergon tremend growth number content make comprehens evalu perform becam import perform comprehens perform assess avail human genotyp array ancestri group use divers public hous dataset analys focus perform estim deriv imput term accuraci coverag pgs term concord pgs estim whole genom sequenc data three differ trait diseas found array higher number snps necessarili one higher imput perform array well optim target popul could provid good imput perform addit pgs estim imput snp array data high correl pgs estim whole genom sequenc data case optim array use correl pgs two type data higher interest array high densiti result lower pgs perform result suggest import proper select suitabl genotyp array pgs applic final develop web tool provid interact analys tag snp content imput perform base popul genom region interest studi would act practic guid research design genotyp array base studi tool avail https genomevinbigdataorgtoolssaa
|
D055106;D015894
|
T063;T028
|
36,266,454
|
development chang action outcom regular perceptu sensit relationship hand motor function year old children along compar model percept action outcom regular involv generat sens agenc addit percept action outcom regular relat motor perform howev studi examin development chang percept action outcom regular current studi measur perceptu sensit action outcom regular manual dexter children age year result show perceptu sensit action outcom regular signific lower year old children year old children signific lower children low manual dexter children medium high manual dexter correl analys reveal signific correl age perceptu sensit action outcom regular signific correl manual dexter perceptu sensit action outcom regular either overal age band present studi suggest perceptu sensit action outcom regular immatur year age may impair year old children poor manual dexter
|
D006225;D009142
|
T039;T023;T042
|
36,266,453
|
angiogen stem cell deliveri platform augment post infarct neovasculatur revers ventricular remodel mani cell base therapi challeng poor local introduc cell use biomateri scaffold question biocompat bio function endotheli progenitor cell epc popular cell type use cell base therapi due robust angiogen potenti limit therapeut capac develop matur vasculatur demonstr joint deliveri human deriv endotheli progenitor cell epc smooth muscl cell smc scaffold free bi level cell sheet platform improv ventricular remodel function athym rat model myocardi infarct transplant bi level cell sheet ischem heart provid biomimet microenviron improv cell cell communic enhanc cell engraft angiogenesi therebi improv ventricular remodel notabl increas densiti vessel like structur upregul biolog adhes vasculatur development gene cxcl notch particular ischem border zone myocardium observ follow cell sheet transplant provid compel evid smc epc bi level cell sheet construct promis therapi repair ischem cardiomyopathi
|
D020257;D009203
|
T047;T042
|
36,266,451
|
remnant cholesterol level associ sever death covid patient coronavirus diseas covid patient sever complic present comorbid like cardiovascular diseas hypertens type diabet mellitus dm share metabol alter like insulin resist ir dyslipidemia object evalu associ among differ compon lipid lipoprotein profil remnant lipoprotein rlp cholesterol patient covid analyz associ sever diseas death studi patient year male hospit covid control year male lipoprotein profil glucos procalcitonin assess patient present higher glucos tg tghdl cholesterol rlp cholesterol level lower total ldl hdl hdl cholesterol level p binari logist regress perform age non hdl cholesterol rlp cholesterol associ death p covid condit worsen accord procalcitonin tertil decreas cholesterol fraction p observ differ tg level rlp cholesterol tghdl cholesterol increas p lower level cholesterol fraction relat presenc sever covid except rlp cholesterol level tghdl cholesterol index alter indic lipid metabol disord characterist ir state covid patient rlp cholesterol level predict sever death patient
|
D002784;D000086382
|
T123;T121;T067;T109;T047
|
36,266,449
|
effect pre oper carbohydr load aspir risk evalu ultrasonographi type diabet patient prospect observ pilot studi owe concern delay gastric empti hyperglycemia evid lack regard whether pre oper carbohydr load routin administ patient type diabet object studi determin aspir risk gastric volum pre oper carbohydr load patient type diabet prospect singl center observ cohort studi studi conduct tertiari teach hospit seoul korea may may patient n type diabet underw elect noncardiac surgeri patient administ carbohydr load two hour surgeri oper room underw gastric ultrasonographi determin gastric volum anesthesiologist monitor patient glucos concentr surgeri primari outcom predict risk aspir secondari outcom gastric volum antral grade satisfact score periop glucos profil forti nine patient analyz patient low risk aspir carbohydr load follow patient classifi antral grade patient classifi antral grade median time carbohydr drink ingest ultrasound examin min iqr carbohydr load median gastric volum right later posit carbohydr load ml iqr mean glucos concentr sd mgdl mgdl mgdl mgdl baselin induct min surgeri post anesthesia care unit respect median satisfact score patient iqr pre oper carbohydr load may feasibl patient type diabet without complicationstri registr clinicaltrialsgov nct regist juli
|
D003924;D000777
|
T039;T121;T047
|
36,266,447
|
oxoguanin oxid damag epigenet epitranscript modif pathophysiolog reactiv oxygen speci control divers cellular phenotyp oxid biomolecul among guanin base nucleic acid vulner produc oxoguanin pair adenin featur oxoguanin dna oxo dg induc g c mutat cancer deleteri thus activ repair dna repair pathway oxoguanin rna g caus problem aberr qualiti translat fidel therebi subject rna decay pathway addit oxid damag oxo dg serv epigenet modif affect transcript regulatori element epigenet modif abil ga base pair g alter structur function rna rna interact enabl redirect posttranscript regul address product regul function oxo dg g oxid stress primarili focus epigenet epitranscript role oxoguanin highlight signific oxid modif redox mediat control gene express
|
D004260;D006147
|
T045;T114
|
36,266,446
|
new insight epitranscriptom control pluripot stem cell fate cell human bodi distinguish fate pluripot stem cell challeng myriad lineag differenti option defect like fatal stem cell somat cell due broad impact former earli develop henc detail understand mechan determin fate stem cell need mechan human pluripot stem cell although fulli equip complex chromatin structur epigenet regulatori mechan accur control gene express import stem cell field review examin event drive pluripot stem cell fate under chang gene express earli develop addit highlight role play epitranscriptom regul gene express necessari fate relat event
|
D018507;D039904
|
T045;T025
|
36,266,445
|
detect technolog rna modif date chemic modif character rna provid new layer gene express regul term epitranscriptom rna modif detect method tool advanc function studi epitranscriptom accord detect throughput principl exist rna modif detect technolog categor four class includ quantif method locus specif detect method next generat sequenc base detect technolog nanopor direct rna sequenc base technolog review summar current knowledg rna modif detect technolog discuss challeng exist detect tool provid inform comprehens understand epitranscriptom
|
D012313;D059014
|
T063;T059;T114
|
36,266,443
|
emerg import mettl mediat ribosom rna methyl studi epitranscriptom thus far focus larg mrna methyl recent human genet studi suggest methyl ribosom rna also contribut brain develop cognit particular modif posit rrna instal mettl mutat delet mettl human mice respect caus abnorm translat gene express turn mediat stem cell behavior differenti review provid overview current knowledg methyltransferas mettl well molecular biolog surround rrna regul cell behavior
|
D012270;D008780
|
T026;T126;T116
|
36,266,441
|
incid depress kidney transplant recipi south korea long term popul base studi depress associ impair qualiti life increas morbid mortal end stage kidney diseas eskd patient kidney transplant kt recipi depress incid kt unclear compar depress incid among kt recipi eskd patient healthi control hcs analyz nationwid health insur databas south korea identifi patient underw kt particip match age sex inclus year kt eskd patient match hypertens diabet mellitus histori incid rate ir per patient year depress compar among kt eskd hc group analyz patient per group depress incid mark lower kt eskd patient ir vs hazard ratio hr confid interv ci slight higher kt recipi hcs ir vs hr ci adjust comorbid depress risk lower kt recipi hcs adjust hr ci p wherea remain higher eskd patient hcs adjust hr ci p among kt recipi older age femal sex lower econom status comorbid associ increas depress risk incid depress kt increas mortal graft failur death censor graft failur risk kt recipi data suggest broader role kt previous appreci term improv qualiti life reduc depress risk
|
D016030;D007676
|
T061;T047
|
36,266,440
|
individu base model reveal covid isol period shorten communiti vaccin isol infect individu quarantin contact usual employ mitig transmiss sar cov although day isol infect individu could effect reduc risk subsequ transmiss also substanti impact patient psycholog emot well therefor vital investig isol durat could shorten effect vaccin avail individu base model approach employ estim likelihood secondari infect likelihood outbreak follow isol primari case rang isol period individu base model integr viral load infecti profil vaccin unvaccin infect individu effect wane vaccin induc immun infect also consid simul transmiss sar cov delta b variant communiti found baselin scenario individu unvaccin nonpharmaceut intervent use approxim chanc unvaccin individu would lead least one secondari infect isol day sustain chain transmiss could occur less chanc outbreak risk equival day isol baselin scenario found isol durat could shorten day ci peopl communiti fulli vaccin bntb vaccin within last three month best case scenario individu communiti fulli vaccin isol delta variant infect individu may longer necessari howev keep outbreak risk lower booster vaccin may necessari three month full vaccin
|
D000086382;D060085
|
T047;T067
|
36,266,439
|
inform decay enzymat inform recoveri dna data storag synthet dna propos storag medium digit inform due high theoret storag densiti anticip long storag horizon howev ambient storag condit dna undergo slow chemic decay process result nick broken dna strand inform store strand longer readabl work design enzymat repair procedur applic dna pool prior readout partial revers damag chemic understand decay process overhang end damag site identifi obstruct repair via base excis repair ber mechan obstruct remov via enzym apurinicapyrimidin endonucleas ape therebi enabl repair hydrolyt damag dna via bst polymeras taq ligas simul damag repair reveal benefit enzymat repair step dna data storag especi data store dna high storag densiti low physic redund long time durat
|
D043603;D004260
|
T045;T126;T116
|
36,266,438
|
addit effect genet metabol factor pathogenesi nonalcohol fatti liver diseas genet metabol factor influenc patholog nonalcohol fatti liver diseas nafld aim retrospect studi evalu impact factor stage diseas analys impact obes diabet mellitus genet risk factor allel pnpla hsdb nonalcohol steatohepat nash signific fibrosi stage advanc fibrosi stage patient genet high risk defin least risk allel median age year median bodi mass index kgm diabet mellitus obes risk factor nash signific fibrosi advanc fibrosi diabet mellitus increas risk nash genet risk increas risk signific advanc fibrosi odd ratio nash signific fibrosi advanc fibrosi increas number genet metabol risk factor patient metabol genet risk odd ratio nash signific fibrosi advanc fibrosi factor strong impact patholog nafld differ accord fibrosi stage synergist effect observ genet metabol factor stage
|
D065626;D003920
|
T047
|
36,266,437
|
establish novel mous model adenomyosi suitabl longitudin quantit analysi perinat outcom studi purpos studi establish novel mous model adenomyosi suitabl longitudin quantit analys perinat outcom studi use g needl entir uterin wall one horn mechan punctur frequenc time cm adenomyosi horn horn left unpunctur control horn balbc mice sacrif day day n uterus fix paraffin embed slice stain lesion detect count volum measur cell prolifer fibrosi assess ki masson trichrom stain respect blood vessel detect use cd immunostain mice n mate date deliveri litter size number implant number volum postpartum lesion measur number lesion per horn differ volum entir lesion signific greater p volum epitheli part lesion signific greater p volum stromal part lesion also greater p percentag ki posit cell epitheli part lesion signific higher p contrast percentag ki posit cell stromal part signific higher p vascular densiti lesion higher p percentag fibrot area signific higher p date deliveri slight earlier report healthi mice strain litter size smaller report previous research number implant site differ control adenomyosi horn number volum lesion differ non pregnant postpartum group model appli evalu pathogenesi adenomyosi valid efficaci therapeut agent evalu effect adenomyosi pregnanc vice versa
|
D062788
|
T047
|
36,266,436
|
dynam chang genom hydroxymethyluracil n methyladenin level drosophila melanogast life cycl respons differ temperatur condit studi level dna modif investig three development stage drosophila melanogast larva pupa imago vitro model schneider cell analysi carri use two dimension ultra perform liquid chromatographi tandem mass spectrometri method made possibl first time analyz broad spectrum dna modif three stage drosophila stage character specif modif pattern level compound fluctuat throughout melanogast life cycl level dna modif also compar insect bred c optim temperatur c group differ signific profound chang n methyladenin hydroxymethyluracil level drosophila life cycl result breed temperatur chang indic dna modif play import regulatori role respons environment chang andor biolog condit moreov supplement schneider cell mm l ascorb acid caus time depend increas level hydroxymethyl deoxyuridin data suggest certain pool compound may aris enzymat activ dtet protein
|
D004331;D008018
|
T079;T204
|
36,266,435
|
reduc renal elimin larger molecul strong predictor mortal renal dysfunct major risk factor prematur death studi extens new renal syndrom shrunken pore syndrom sps confer higher mortal studi popul sps condit cystatin c base estim glomerular filtrat rate egfr cystatin c creatinin base estim glomerular filtrat rate egfr creatinin aim studi impact sps mortal cohort patient follow year retrospect singl centr cohort studi enrol consecut patient undergo elect cardiac surgeri outcom evalu use kaplan meier analysi multivari cox regress year surviv patient sps without sps p sps found independ predictor mortal hr ci sps negat affect surviv regardless pre oper renal function sps independ predictor mortal elect cardiac surgeri equal greater risk factor diabet impair left ventricular function renal dysfunct sps affect mortal even patient normal egfrclin registr number clinicaltrialsgov id nct
|
D055316;D007674
|
T121;T047;T116
|
36,266,434
|
determin antimicrobi agent transform product agricultur water soil system modifi manur manur fertil primari sourc veterinari antimicrobi water soil system research gap fate antimicrobi releas environ studi aim provid detail multi facet examin fertil cultiv field use two type manur poultri bovin enrich select antimicrobi research focus assess mobil stabil antimicrobi water soil system addit transform product antimicrobi environ identifi extract solid phase extract andor solid liquid extract lc msms analysi procedur develop determin antimicrobi soil pore water sampl ten fourteen antimicrobi detect manur amend soil pore water sampl highest concentr soil ng g doxycyclin pore water ng l ciprofloxacin sixteen transform product antimicrobi identifi soil soil relat pore water transform product detect soil soil pore water extract signific higher signal intens observ soil extract water transform product form oxid carbonyl ring open reaction
|
D012989;D019155;D000890
|
T131;T121
|
36,266,433
|
heterogen graph neural network lncrna diseas associ predict identifi lncrna diseas associ conduc diagnosi treatment prevent diseas due expens time consum method verifi biolog experi predict method base comput model gradual becom import mean lncrna diseas associ discoveri howev exist method still challeng make full use network topolog inform identifi potenti associ lncrna diseas multi sourc data studi propos novel method call hgnnlda lncrna diseas associ predict first hgnnlda construct heterogen network compos lncrna similar network lncrna diseas associ network lncrna mirna associ network heterogen network various type strong correl neighbor fix size sampl node restart random walk next embed inform lncrna diseas lncrna diseas associ pair obtain method type base neighbor aggreg type combin though heterogen graph neural network attent mechan introduc consid differ type neighbor make differ contribut predict lncrna diseas associ result area receiv oper characterist curv auc area precis recal curv aupr fivefold cross valid fcv respect compar five state art predict model hgnnlda better predict perform addit two type case studi verifi method effect predict potenti lncrna diseas associ abil predict new diseas without known lncrnas
|
D062085;D035683
|
T123;T114
|
36,266,432
|
clinic characterist children guardian possess cbp posit streptococcus mutan strain cross section studi streptococcus mutan major etiolog agent dental cari previous demonstr mutan strain express collagen bind protein cbps relat pathogenesi system diseas howev acquisit colon remain unknown investig detect rate cbp posit mutan strain children guardian clarifi background acquisit colon children saliva sampl collect children mother detect mutan collagen bind gene cnm cbm perform pcr dna extract oral status child examin mother ask complet questionnair isol rate cnm posit mutan signific higher mother children notabl possess rate cbp posit strain children signific higher children whose mother cbp posit strain children whose mother strain furthermor children cbp posit strain signific shorter breastfeed period children without strain present result suggest nutrit feed habit infanc one factor involv acquisit colon cbp posit mutan strain
|
D013295;D003731
|
T033;T047;T007
|
36,266,431
|
random trial assess efficaci silymarin endometrioma relat manifest studi effect silymarin interleukin il level size endometrioma lesion pain sexual function qualiti life qol women diagnos endometriosi random doubl blind placebo control clinic trial perform women endometriosi divid two group intervent control intervent mg silymarin match placebo administ twice daili week volum endometrioma lesion level il concentr serum pain sexual function qol analyz intervent mean endometrioma volum p il p pain p silymarin signific reduc interleukin level size endometrioma lesion pain relat symptom trial regist iranian registri clinic trial irctn th februari https enirctirtri date initi particip enrol nd march
|
D004715;D012838
|
T121;T047;T191;T109
|
36,266,430
|
comparison inhibitori effect tocilizumab etanercept progress joint eros rheumatoid arthriti treatment compar efficaci tocilizumab etanercept inhibit radiograph progress joint destruct rheumatoid arthriti overal patient treat etanercept tocilizumab select adjust baselin patient characterist tocilizumab etanercept treatment group propens score match perform radiograph progress joint destruct compar patient treat tocilizumab etanercept clinic diseas activ index cdai modifi health assess questionnair mhaq score administr biolog treatment month tocilizumab etanercept therapi measur compar radiograph paramet group level c reactiv protein crp matrix metalloproteinas mmp cdai mhaq score improv month treatment two group proport patient sharp eros score progress signific higher tocilizumab treatment etanercept treatment p multivari analysi demonstr sharp eros score signific associ baselin cdai odd ratio confid interv p tocilizumab treatment suppress joint eros progress compar etanercept progress correl baselin cdai
|
D018501;D001172;D001688;D061067
|
T129;T121;T123;T116;T047
|
36,266,429
|
hepat urea creatinin uric acid metabol dairi cow diverg milk urea concentr milk urea concentr indic dietari nitrogen n suppli urinari n excret dairi cow high hmu compar low milk urea lmu concentr greater plasma urea creatinin uric acid concentr liver metabol account differ unknown eighteen hmu lmu cow fed diet low lp normal np crude protein concentr n balanc studi perform c urea bolus administ measur urea pool size liver sampl analyz gel base proteom rt qpcr although hmu cow greater urea pool plasma urea uric acid hippur acid concentr differ associ alter express gene relat urea cycl n metabol instead hmu cow higher oxid stress level conclus factor hepat urea metabol account milk urea concentr despit higher plasma urea concentr argininosuccin synthas protein express lp diet urea cycl mrna express affect indic activ control transcript level feed lp diet result increas express enzym catabol fatti acid reason remain investig futur studi
|
D008892;D014508
|
T121;T123;T109;T168;T031
|
36,266,428
|
role e ubiquitin ligas hakai intestin inflamm cancer bowel diseas e ubiquitin ligas import cellular protein homeostasi deregul implic cancer e ubiquitin ligas hakai involv tumour progress metastasi regul tumour suppressor e cadherin hakai overexpress colon cancer howev implic coliti associ cancer unknown investig potenti role hakai intestin inflamm cancer bowel diseas sever mous model coliti associ cancer use analys hakai express immunohistochemistri also analys hakai express patient inflam colon biopsi ulcer coliti crohn diseas hakai interactom analysi identifi fatti acid synthas fasn novel hakai interact protein moreov show hakai induc fasn ubiquitin degrad via lysosom thus regul fasn mediat lipid accumul invers express fasn hakai detect inflammatori aomdss mous model conclus hakai regul fasn ubiquitin degrad result regul fasn mediat lipid accumul associ develop inflammatori bowel diseas interact hakai fasn may import mechan homeostasi intestin barrier function pathogenesi diseas
|
D003110;D044767;D003092
|
T047;T191;T126;T116
|
36,266,427
|
mous model hepat encephalopathi bile duct ligat induc brain ammonia overload glial cell activ neuroinflamm hepat encephalopathi common complic chronic liver diseas character alter mental state hyperammonemia insight brain pathophysiolog limit due pauciti well character model beyond rat bile duct ligat bdl model assess presenc characterist mous bdl model show bdl cblj mice induc motor dysfunct progress liver fibrosi liver function failur hyperammonemia hallmark swiss mice howev fail replic phenotyp underscor import care strain select next depth characteris metabol disturb cerebrospin fluid bdl mice show glutamin accumul transient decreas taurin cholin indic brain ammonia overload moreov mous bdl induc glial cell dysfunct name microgli morpholog chang neuroinflamm astrocyt reactiv blood brain barrier bbb disrupt final identifi putat novel mechan involv central pathophysiolog like bile acid accumul tryptophan kynurenin pathway alter studi provid first comprehens evalu mous model chronic liver diseas addit studi underscor import neuroinflamm central effect chronic liver diseas
|
D006501;D022124;D008107
|
T033;T047
|
36,266,426
|
biofunct soy base sourdough improv rheolog properti storag frozen dough storag along thaw process negat affect qualiti final product thus ferment select cultur enrich wheat base dough use specif soy powder could optim viscoelast qualiti frozen dough increas nutrit characterist base aspect present studi object examin effect soy powder addit wheat flour singl cultur fructilactobacillus florum dsm saccharomyc cerevisia cocultur two microorgan h ferment addit ferment process monitor viscoelast behavior physic chemic analys ferment sourdough frozen storag assess soy protein propos hinder water migrat throughout frozen storag observ soy powder essenti function ingredi favor impact water starch gluten system enhanc viscoelast behavior week frozen storag
|
D005433;D001939
|
T168
|
36,266,424
|
model dilat sagitt sinus found multipl sclerosi suggest increas wall stiff may contribut factor cross section area superior sagitt sinus sss larger multipl sclerosi normal correl diseas sever progress sinus could enlarg due decreas pressur differ lumen subarachnoid space increas wall thick increas wall stiff cross section area sss straight sinus st measur patient multipl sclerosi compar control cross section area sss st increas compar control p respect deflect wall sinus estim chang pressur gradient wall thick elast modulus group calcul model wall simpli support beam account find model suggest either reduct transmur venous pressur fold increas sss wall stiff plus increas wall thick combin chang increas sinus pressur although straight forward possibl account chang sinus size may exist minor patient increas sinus wall stiff thick may need investig
|
D009103
|
T047
|
36,266,423
|
transit matric model way better understand predict intra hospit pathway covid patient sinc januari sar cov pandem sever affect hospit system worldwid europ first epidem wave period sever term number infect hospit patient sever descript demograph clinic profil patient covid studi hospit pathway use transit matric construct markov chain illustr transit probabl differ hospit ward patient march juli manag pari area identifi epidem period wave number hospit patient signific high period main differ observ direct admiss icu mortal icu length stay aliv patient day ch day icu proport patient transfer ch icu remain stabl understand hospit pathway patient crucial better monitor anticip impact sar cov pandem health system
|
D000086382
|
T047;T067
|
36,266,422
|
sociodemograph characterist health relat qualiti life individu undergo antidepress therapi import factor avert depress creat awar clinic treatment patient prefer therefor investig health relat qualiti life associ differ antidepress necessari retrospect cohort studi perform use medic expenditur panel survey mep nation repres databas civilian noninstitution popul span differ age sex wide rang sociodemograph econom background differ clinic sociodemograph characterist among patient use differ antidepress class explor differ veteran rand item health survey vr result among group examin vr metric use sinc measur patient overal perspect health approxim million patient report use least one antidepress patient receiv tricycl therapi report substanti better mental hrqol patient receiv select serotonin reuptak inhibitor ssris serotonin norepinephrin reuptak inhibitor snris combin therapi patient receiv atyp antidepress report substanti better mental hrqol receiv type antidepress patient report substanti declin hrqol snris combin therapi studi found hrqol vari across antidepress user thus health care provid could benefit take consider qualiti life prescrib antidepress agent moreov research need explor factor could contribut qualiti care patient depress
|
D000068760;D018687
|
T121
|
36,266,421
|
autom photo align liquid crystal elastom film fabric low tech home built robot workstat laboratori procedur often consid uniqu autom econom justifi time resourc invest design build calibr machin unlik pay particular true cheap labour forc technician student avail yet increas avail drop price mani shelf compon motoris stage gripper light sourc led laser detector high resolut fast camera well user friend programm microprocessor mani repeat task may soon within reach either custom built univers lab robot build previous work fabric character applic light respons liquid crystal elastom lces micro robot micro mechan paper present robot workstat make lce film arbitrari molecular orient base commerci printer robolec robot lce fabric perform precis compon handl structur light illumin liquid dispens uv trigger polymer within four hour long procedur thus fabric film pattern molecular orient compar handmad structur
|
D050866;D012371
|
T090;T104;T073
|
36,266,420
|
divers myxozoan parasit catfish rhamdia quelen siluriform heptapterida southeastern brazil base morpholog molecular evid rhamdia quelen commerci import fish south america survey myxozoan infect fish pardo river paranapanema river basin paulo state brazil describ three new speci henneguya found parasit gill r quelen henneguya bagr n sp henneguya breviscauda n sp henneguya novaera n sp descript base myxospor morpholog small subunit ribosom dna partial sequenc phylogenet analysi show clade form speci parasit siluriform henneguya jundiai sister speci henneguya bagr n sp henneguya breviscauda n sp henneguya novaera n sp studi indic parasit infect r quelen belong lineag myxozoan infect heptapterida fish use molecular morpholog character speci identifi new speci genus henneguya base analysi recommend monitor presenc parasit farm fish analyz possibl patholog caus
|
D002397;D005393;D055764
|
T047;T204;T013
|
36,266,419
|
dynam econometr analysi influenc factor product effici construct industri guangxi provinc china china construct industri assum import role china urban process improv china urban landscap level nation product live facil product construct industri region china still relat low level take construct industri guangxi provinc southwest china exampl paper analyz relev index affect total factor product level region construct industri compos statist relationship among index use dynam measur method obtain number employe enterpris labor product construct profit posit influenc total factor product guangxi construct industri improv region construct gross product drive improv technic equip rate dynam equilibrium relationship input output indic total factor product guangxi construct industri posit drive effect output indic input indic obvious influenc input indic output indic greater posit influenc accord paper also put forward correspond suggest promot technic product level guangxi construct industri
|
D060389
|
T090
|
36,266,418
|
tactil facilit actual mere expect object recept reach grasp movement tactil process typic suppress howev recept catch task object still acquir without suppress process relat movement execut rather tactil inform may facilit object approach anticip object contact util tactil feedback therefor current studi investig tactil process recept task particip sat upper limb still object travel contact finger differ point along object trajectori prior contact particip ask detect tactil stimuli deliv index finger understand expect object contact contribut modul tactil process object stop prematur trial compar pre object movement baselin relat perceptu threshold decreas throughout object trajectori even object stop prematur evid modul stimulus present short object contact former result suggest tactil process facilit object approach individu hand well purport expect tactil feedback drive modul final latter result suggest peripher mask may reducedabolish facilit
|
D011597;D009042
|
T078;T041;T080
|
36,266,417
|
behaviour real time spatial track identif berstid use cat behaviour monitor anim shelter effici track anim behaviour anim shelter direct lifesav applic individu care earli recognit distress cat often miss howev monitor behaviour challeng time financi resourc often limit size need anim popul within shelter common flux research requir method behaviour observ simpl access use limit human comput resourc allow real time feedback present berstid open sourc behaviour real time spatial track identif system demonstr six cat anim shelter use uniqu fiduci marker marker attach custom veterinari paper identif collar feedback individu anim behaviour time find show berstid correl close human code data real time post event process mode eat drink behaviour cat naturalist shelter environ build upon later concept marker track direct appli use new context present low barrier user friend solut use common technolog track anim research develop may help improv welfar anim care facil shelter extens berstid may general track uniqu subject vari environ multipl use case
|
D000827;D000822
|
T090;T053;T052
|
36,266,416
|
trainabl joint bilater filter enhanc predict stabil low dose ct low dose comput tomographi ct denois algorithm aim enabl reduc patient dose routin ct acquisit maintain high imag qualiti recent deep learn dl base method introduc outperform convent denois algorithm task due high model capac howev transit dl base denois clinic practic data driven approach must general robust beyond seen train data therefor propos hybrid denois approach consist set trainabl joint bilater filter jbfs combin convolut dl base denois network predict guidanc imag propos denois pipelin combin high model capac enabl dl base featur extract reliabl convent jbf pipelin abil general demonstr train abdomen ct scan without metal implant test abdomen scan metal implant well head ct data embed red cnnqae two well establish dl base denois pipelin denois perform improv rmse psnr region contain metal rmse psnr head ct data compar respect vanilla model conclud propos trainabl jbfs limit error bound deep neural network facilit applic dl base denois low dose ct pipelin
|
D007091;D014057
|
T060;T066
|
36,266,414
|
comparison fractal grid electrod studi effect spatial confin dissoci retin neuron glial behavior understand impact geometri materi composit electrod surviv behavior retin cell import fundament cell studi neuromodul applic investig dissoci retin cell cblj mice interact electrod made vertic align carbon nanotub grown silicon dioxid substrat compar electrod differ degre spatial confin specif fractal grid electrod featur connect disconnect gap electrod respect electrod find neuron process predomin accumul electrod rather gap surfac behavior strongest grid electrod howev close charact grid electrod gap inhibit glia cover gap surfac lack glial coverag grid expect long term detriment effect neuron surviv electr activ contrast interconnect gap within fractal electrod promot glial coverag describ differ cell respons two electrod hypothes optim geometri maxim posit respons neuron glia interact electrod
|
D037742;D055351
|
T104;T073;T025
|
36,266,413
|
breast milk mesenchym stem cell abat cisplatin induc cardiotox adult male albino rat via modul ampk pathway myocardi injuri influenc cisplatin cis compel reason hunt treatment modal overcom threat cisplatin treat patient breast milk mesenchym stem cell br mscs non invas high reproduc sourc stem cell herein investig br mscs role cardiotox induc cisplatin rat divid control cis treat receiv mgkg singl intraperiton inject brmscs treat receiv singl intraperiton inject ml steril phosphat buffer salin contain cell br mscs metformin treat receiv mgkgday oral brmscs metformin cis treat group experi end serum creatin kinas ck mb cardiac troponin ctnt activ estim cardiac malondialdehyd mda superoxid dismutas sod interleukin il tumor necrosi factor tnf level measur cardiac express bax bcl amp activ protein kinas ampk well heart histopatholog evalu studi result show cis explor acut cardiotox evidenc deterior cardiac indic induct oxid stress inflamm myocardium histolog alter treatment br mscs restor heart function structur deterior cis inject antioxidantanti inflammatoryanti apoptot result br mscs support ampk activ denot protect role cisplatin induc cardiac injuri result superior metformin ad treatment protocol
|
D066126;D002945;D059630;D008687
|
T121;T025;T109;T197;T037
|
36,266,412
|
sarcopenia mortal risk communiti dwell brazilian older adult estim impact sarcopenia paramet mortal risk assess preval associ factor older adult accord european work group sarcopenia older peopl ewgsop ewgsop criteria year follow cohort studi low muscl mass mm defin low skelet muscl mass index smi use dual energi x ray absorptiometri dxa low calf circumfer cc cox regress kaplan meier method perform preval sarcopenia associ factor influenc mm measur method diagnost criteria use smi ewgsop cc ewgsop smi ewgsop cc ewgsop low bmi associ sarcopenia regardless sarcopenia definit diabet high tgs associ sarcopenia use ewgsop criteria low smi increas mortal risk ewgsop hr ci ewgsop hr ci preval sarcopenia higher accord ewgsop ewgsop low bmi diabet high tgs associ sarcopenia low smi doubl risk mortal communiti dwell older adult
|
D055948
|
T047
|
36,266,411
|
critic path produc high qualiti reproduc data quantit western blot experi western blot experi initi perform detect target protein complex biolog sampl recent measur relat protein abund chemiluminesc coupl film base detect tradit gold standard western blot accur reproduc quantif major challeng methodolog develop sensit camera base detect technolog coupl updat technic approach permit product reproduc quantit data fluoresc reagent detect solut latest innov western blot remain question debat concern relat sensit dynam rang versus chemiluminesc methodolog optim produc excel quantit western blot result rigor data analysi membran probe fluoresc chemiluminesc antibodi describ data reveal appli detect method achiev reproduc data stepwis approach data process quantit analysi
|
D019091;D011506
|
T123;T170;T116
|
36,266,410
|
count hyaluron acid contain extracellular vesicl decreas natur occur equin osteoarthr osteoarthr oa degen joint diseas inadequ understood pathogenesi lead pain function limit extracellular vesicl ev releas synovi joint cell induc pro anti oa effect hyaluron acid ha lubric surfac articular cartilag one bioactiv molecul transport ev human alter ev count composit observ oa synovi fluid sf ev research earli stage hors well recogn oa model aim character sf ev ha cargo hors sf collect euthanasia control oa contralater metacarpophalang joint sf ha concentr size distribut determin sandwich type enzym link sorbent assay size exclus chromatographi ultracentrifug follow nanoparticl track analysi nta util quantifi small ev confoc laser scan microscopi clsm imag analysi character larger ev number size distribut small ev measur nta unaffect oa result may limit lack hyaluronidas pre treatment sampl visual clsm number proport larger ha contain ev ha ev decreas oa sf general linear model count p p invers associ oa grade total ev count ha ev count ha ev r p total ha concentr also lower oa general linear model p conclud present studi discov potenti sf biomark ha ev natur occur equin oa role ha ev pathogenesi oa potenti joint diseas biomark therapeut target warrant futur studi
|
D002358;D000067128;D010003
|
T026;T047;T024
|
36,266,409
|
relationship intens gasterophilus intestinali larva infect serum salivari humor immun respons hors infect gasterophilus intestinali botfli larva often occur hors aim studi isol larva g intestinali evalu serum salivari humor immun respons use self develop elisa g intestinali infect hors blood serum saliva sampl taken infect hors uninfect slaughter hors antigen g intestinali larva use develop elisa order evalu intens g intestinali igg igm iga antibodi reactiv serum saliva natur infect hors hors without larva gastrointestin tract control group serum antibodi second third larva stadium antigen react signific intens infect healthi hors igg p p respect iga p p respect class salivari igg iga specif antibodi reactiv signific higher hors moder p sever infect p compar healthi hors determin g intestinali igg iga antibodi activ saliva serum may use detect hors moder sever infest larva
|
D006734;D004175
|
T047;T204
|
36,266,408
|
micro express recognit model base tv l optic flow method improv shufflenet micro express kind facial action reflect real emot state person high object emot detect therefor micro express recognit becom one research hotspot field comput vision recent year research neural network convolut structur still one main method recognit method advantag high oper effici low comput complex disadvantag local featur extract recent year plug play self attent modul use convolut neural network improv abil model extract global featur sampl paper propos shufflenet model combin miniatur self attent modul million train paramet first start frame vertex frame sampl taken tv l optic flow featur extract optic flow featur fed model pre train final weight obtain pre train use initi weight model train complet micro express sampl classifi svm classifi evalu effect method train test composit dataset consist casmeii smic samm model achiev competit result compar state art method cross valid leav one subject
|
D057849
|
T040
|
36,266,407
|
determin interpret network represent link predict intuit descript complex physic social brain system complex network fascin scientist decad recent abstract network topolog dynam attribut network represent preval techniqu map network substructur like node low dimension vector space sinc mainstream method most base machin learn black box input output data fit mechan learn vector dimens indetermin element interpret although massiv effort cope issu includ say autom machin learn comput scientist learn theori mathematician root caus still remain unresolv consequ enterpris need spend enorm comput resourc work set model hyperparamet bring good perform busi personnel still find difficulti explain learn vector practic mean given physic perspect articl propos two determin interpret node represent method evalu effect general articl propos adapt interpret prob aiprob network base model util node represent link predict experiment result show aiprob reach state art precis beyond baselin model small data whose distribut train test set usual unifi enough machin learn method perform well besid make good trade machin learn method precis determinaci robust interpret practic work contribut industri compani without enough comput resourc pursu good result base small data earli stage develop requir high interpret better understand carri busi
|
D000069550
|
T066
|
36,266,406
|
extend visuomotor experi invert movement overcom invers effect biolog motion percept studi demonstr perceiv human anim movement point light display effortless howev simpli invert display signific impair abil compar non dancer typic dancer vertic dancer uniqu experi observ perform movement upsid suspend air studi whether uniqu visuomotor experi make better perceiv invert movement present ten pair danc movement point light display pair includ version perform ground wherea air invert display half trial ask vertic dancer typic dancer non dancer whether display invert found vertic dancer extend visual motor experi configur dynam inform movement could identifi invers movement perform air neither typic dancer non dancer motor experi perform invert movement could detect invers find suggest motor experi play critic role enabl observ use dynam inform identifi artifici invers biolog motion
|
D009039;D003615
|
T056;T041
|
36,266,404
|
mental distress associ factor among colleg student kemisi district ethiopia mental health problem distress affect societi non differenti fashion recent decad mental distress becom common health problem among student regard limit inform problem avail ethiopia therefor studi aim determin preval associ factor mental distress among colleg student kemisi district ethiopia institut base cross section studi conduct among student februari stratifi sampl techniqu use select studi particip data collect use structur self administ questionnair self report questionnair refer srq standard questionnair item question use tool mental distress appropri descript statist done binari logist regress model use identifi factor associ mental distress adjust odd ratio confid interv comput determin level signific p valu use declar statist signific variabl preval mental distress among student ci close friend aor ci attend religi program aor ci conflict friend aor ci pocket money aor ci ever use chat aor ci current use chat aor ci decreas grade anticip aor ci low moder social support aor ci aor ci respect statist signific associ factor mental distress overal preval mental distress among student kemisi district ethiopia high ethiopia along current econom crisi absenc social support problem could increas therefor mental health need colleg student requir attent special emphasi close friend never attend religi program conflict friend absenc pocket money student use khat low social support
|
D013334;D001523
|
T081;T098;T048
|
36,266,403
|
predict malign lymph node nsclc machin learn classifi use ebus tbna petct accur determin lymph node ln metastas prerequisit high precis radiotherapi primari aim characteris perform petct base machin learn classifi predict ln involv endobronchi ultrasound guid transbronchi needl aspir ebus tbna stage iii nsclc predict model ln posit base f fdg petct featur built use logist regress machin learn model random forest rf multilay perceptron neural network mlp stage iii nsclc radiochemotherapi total ln station sampl patient logist rf model identifi suv max short axi ln diamet echelon consid ln among import paramet ebus posit adjust sensit machin learn classifi expert rater mlp p rf model p show lower misclassif rate mcr standard report weight fals posit fals negat equal increas sensit classifi result increas mcr mlprf respect petct base machin learn classifi achiev high sensit detect ebus posit lns low misclassif rate specif decreas rapid level combin test petct base mlprf classifi ebus tbna recommend radiat target volum definit
|
D008175;D002289
|
T191
|
36,266,402
|
epigenet impact week intens multimod group program adolesc multipl advers childhood experi advers childhood experi ace ie abus neglect household dysfunct repres potenti risk factor wide rang long last diseas shorter life expect recent describ week residenti group program base mind train artist express emdr group therapi signific reduc ptsd relat symptom increas attentionawar relat outcom adolesc girl multipl ace random control studi sinc epigenet mechan ie dna methyl associ long last effect ace present report extend prior find explor genom wide dna methyl chang follow program saliva sampl particip n collect genom dna extract prior follow intervent genom wide dna methyl analysi use methylationep beadchip array illumina reveal differenti methyl loci dml p valu annot gene role biolog process link earli childhood advers ie neural immun endocrin pathway cancer cardiovascular diseas dna sequenc flank dml show signific enrich transcript factor bind site involv inflamm cancer cardiovascular diseas brain develop methyl chang sirt trappcl gene show associ chang trauma relat psycholog measur result present suggest multimod group program adolesc multipl victim modul dna methylom site potenti relev health behavior disord associ ace
|
D000076783;D044127
|
T033;T045
|
36,266,400
|
chemic form cadmium soil distribut french marigold sub cell respons chelat glda use degrad chelat agent facilit phytoextract promis low cost method remedi heavi metal contamin soil howev studi plant soil respond chelat agent studi respons french marigold taget patula l soil cadmium cd chelat tetrasodium glutam glda investig field trial five glda treatment kg hm carri cd contamin soil mg kg french marigold plantat result show applic glda promot transform form cd soil exchang state exchang cd fe mn oxid bound state increas p respect cell wall cd accumul signific increas p percentag solubl fraction increas p furthermor increas occur soil ph well doc dtpa cd content increas total amount glda composit applic glda kg hm french marigold reduc total soil cd content compar soil background altogeth result studi suggest applic glda effect activ soil cd enhanc capabl french marigold remedi cd contamin soil
|
D031686;D012989;D019216;D033321
|
T131;T196;T204;T002
|
36,266,399
|
motif conserv modul analysi dna promot enhanc rna lncrna mrna use almodul nucleic acid motif consist conserv variabl nucleotid region function action sever motif combin modul tool aimodul allow identif motif includ combin conserv sever nucleic acid stretch aimodul recogn conserv motif combin motif modul allow number interest biolog applic analysi promot transcript factor bind site tfbs identif conserv modul share sever gene famili eg promot region also analysi share conserv dna motif enhanc silenc mrna motif regulatori element eg polyadenyl lncrnas tool aimodul present integr solut motif analysi offer web servic well download softwar sever nucleotid sequenc queri tfbss use predefin matric jaspar db use one matric divers type dna rna motif discoveri furthermor aimodul find tfbss common two sequenc demand high low conserv aimodul outperform solut speed find modul specif combin tfbs altern avail softwar applic also search rna motif polyadenyl site rna protein bind motif well dna motif enhanc well user specifi motif combin https bioinfo wuerzdeaimodul altern entri page https aimodulesheinzelabd https wwwbiozentrumuni wuerzburgdebioinfocomputingaimodul applic free open sourc whether use onlin site local
|
D062085
|
T123;T114
|
36,266,398
|
oral supplement select lactobacillus acidophilus trigger il depend innat defens respons activ innat lymphoid cell type improv coliti live biotherapeut product constitut emerg therapeut approach prevent treat inflammatori bowel diseas lactobacillus acidophilus constitu human microbiota probiot potenti illustr improv intestin inflamm antimicrobi activ sever pathogen studi evalu immunomodulatori properti l acidophilus strain bio steadi state upon acut inflamm supplement nave mice bio heighten transcript level il target gene encod protein microbicid activ independ nod signal bio induc express angiogenin blunt monocolon mice defici receptor il nod interest prime bone marrow deriv dendrit cell bio enhanc abil support secret il cd cell equal import product il type innat lymphoid cell concomit heighten respons bio administ alon combin bifidobacterium animali spp lacti bio limosilactobacillus reuteri bio abl allevi least partial intestin inflamm induc citrobact rodentium infect furthermor bio also abl improv coliti induc trinitrobenzen sulfon acid tnbs conclus identifi new potenti probiot strain manag inflammatori bowel diseas provid insight il depend independ mode action
|
D003092;D007113;D015212;D007779;D019936
|
T047;T032;T007
|
36,266,397
|
embed cognit framework self attent interpret knowledg trace recent deep neural network base cognit model deep knowledg trace introduc field learn analyt educ data mine despit accur predict perform model challeng interpret behavior obtain intuit insight latent student learn status address challeng paper propos new learner model framework name eakt emb structur cognit model transform way eakt achiev excel predict result learn outcom also depict student knowledg state multi dimension knowledg compon kc level perform fine grain analysi student learn process propos framework provid better explanatori learner model design implement intellig tutor system propos eakt verifi experi perform experi show eakt better predict futur perform student learn higher baselin method two three real world dataset interpret experi demonstr student knowledg state obtain eakt closer ground truth model mean eakt accur trace chang student knowledg state
|
D016571;D019359
|
T170
|
36,266,396
|
attent neuroenhanc tdcs neurofeedback random singl blind control trial neurofeedback transcrani direct current stimul tdcs promis techniqu neuroenhanc attent perform far know studi compar techniqu attent perform healthi particip compar tdcs neurofeedback random singl blind control experi assess behavior accuraci time reaction electrophysiolog n p p compon data particip respond attent network task ant eighti volunt volunt studi adopt standard protocol techniqu ie sensorimotor rhythm smr protocol neurofeedback right dlpfc anod stimul tdcs appli nine session two week find signific differ treatment group ant neither behavior electrophysiolog level howev found particip neuromodul group irrespect activ sham report attent improv respons treatment subject scale studi add anoth null result neuromodul literatur show neurofeedback tdcs effect complex previous suggest associ placebo effect studi neuroenhanc literatur necessari fulli comprehend neuromodul mechan
|
D065908;D058765
|
T061;T041
|
36,266,394
|
structur function correl vision loss neuromyel optica spectrum disord optic neuriti neuromyel optica spectrum disord nmosd regular lead profound vision loss compar multipl sclerosi ms myelin oligodendrocyt glycoprotein antibodi associ diseas mogad investig relat vision loss nmosd compar ms mogad order identifi neuroaxon retin contributor visual dysfunct retrospect studi includ patient aquaporin antibodi seroposit nmosd n mogad n ms n control n assess optic nerv damag fovea morphometri optic coher tomographi visual function assess high hcva low contrast visual acuiti lcva visual field mean deviat md diseas lower visual function associ peripapillari retin nerv fiber layer prnfl ganglion cell inner plexiform layer gcip thin follow broken stick model prnfl gcip cutoff point ca hcva loss per prnfl gcip thin stronger nmosd compar mogad foveal inner rim volum contribut md lcva nmosd eye togeth data support visual dysfunct nmosd associ neuroaxon damag beyond effect seen ms mogad primari retinopathi respect mller cell patholog may contribut effect
|
D009471;D009902;D009103;D020346
|
T123;T047;T116
|
36,266,393
|
recapitul embryon transcript program holometabol insect pupa holometabol insect predomin motionless metamorphosi activ feed observ bodi enclos harden cuticl physiolog properti well undergo process resembl embryogenesi sinc pupal stage organ system imago form therefor recapitul embryon express program metamorphosi could hypothes assess hypothesi transcriptom level perform comprehens analysi development dataset avail public domain inde dataset pupal gene express resembl embryon rather larval pattern interrupt gradual chang transcriptom moreov chang transcriptom profil pupa imago transit posit correl embryo larva transit suggest similar express program activ gene set chang express level larval stage revert embryon like state metamorphosi enrich gene associ metabol develop
|
D018507;D008675
|
T045;T040
|
36,266,391
|
evalu circl willi variant use magnet reson angiographi circl willi cow import collater pathway protect persist cerebr blood perfus studi aim investig morpholog variant signific vascular structur larg studi popul patient undergon mr angiographi mra evalu enrol studi mra imag patient obtain three dimension time flight techniqu interpret measur vessel diamet compon cow classifi cow variat addit correl vessel calib integr cow gender age group present femal domin studi popul mean age type common variat anterior posterior circul type g h common variat anterior circul type e second third common variat posterior cow respect smaller calibr ica ps ba observ femal compar male group diamet ba p segment lower left pcom diamet signific higher patient complet circl signific sex age differ regard distribut complet partial complet incomplet circl group signific differ vessel calib specif compon cow complet partial incomplet circul reveal studi explain research addit meta analys studi literatur might guid understand morpholog alter cow relationship complet non complet circl
|
D002941;D018810
|
T060;T023
|
36,266,390
|
investig mix viscoplast fluid modifi anchor impel insid cylindr stir vessel use casson papanastasiou model process engin chemic biotechnolog industri agit vessel common use various applic mechan agit mix perform enhanc heat transfer improv specif physico chemic characterist insid heat tank research subject work numer investig thermo hydrodynam behavior viscoplast fluid casson papanastasiou model stir tank introduc new anchor impel design conduct modif standard anchor impel shape four geometri case present achiev mix process insid stir vessel cai classic anchor impel ai anchor impel ad horizont arm blade ai ai anchor impel two three ad arm blade respect investig focus effect inertia plastic thermo hydrodynam behavior flow pattern power consumpt heat transfer vari reynold number bingham number bn addit effect geometri design overal stir system paramet find reveal excel enhanc flow pattern heat transfer stir system relat increas inertia valu also energi reduct remark effect anchor impel shape ai geometri design signific improv flow pattern enhanc heat transfer increas rate case
|
D019149;D057446
|
T074;T070
|
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