PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
|---|---|---|---|
36,235,662 | food cost children adolesc consum vegetarian vegan omnivor diet result cross section vechi youth studi aim analys total food cost impact food group total food cost among vegetarian vegan omnivor children adolesc germani base three day weigh dietari record year old children adolesc vechi youth studi total daili food cost food group cost eurday eur kcal vegetarian n record vegan n omnivor n diet calcul minimum retail price empir select food report dietari record link individu food intak group differ analys use ancova kruskal walli test vegan highest energi adjust total food cost eur kcal vegetarian lowest eur kcal omnivor also signific higher cost vegetarian eur kcal kcal p total cost differ signific omnivor vegan eurd eur kcal compar vegetarian vegan signific higher expenditur eurday fruit p veget p dairi altern p legumesnutsse p expenditur starchi food signific higher vegetarian vegan omnivor diet p omnivor spent quarter total food cost anim sourc food equival sum food cost legumesnutsse dairi altern meat altern vegan addit dairi vegetarian vechi youth studi indic financi constraint necessarili barrier switch plant base diet | D014676;D000066989 | T098;T061;T033 |
36,235,661 | posit u shape associ elev hemoglobin concentr level metabol syndrom metabol compon find taiwan biobank uk biobank iron overnutrit implic higher risk develop metabol cardiovascular diseas includ metabol syndrom met wherea iron defici anemia exacerb mani under chronic condit hemoglobin hb concentr blood reflect major function iron ie heme iron bodi may serv surrog nutrit status iron conduct sex specif observ associ studi care titrat associ hb decil met compon among taiwanes han chines hc taiwan biobank european white ancestri uk biobank repres two larg ethnic data show higher normal level hb increas decil hb concentr signific associ met across sex subgroup ethnic highest decil result three time greater risk refer group taiwanes hc ci hb gdl men hb gdl women european white hb gdl men hb gdl women associ stronger risk increas hb decil similar observ metabol compon except diabet found highest hb decil group contrarili lowest one respect refer associ higher odd diabet ethnic group eg taiwanes hc men hb gdl hb gdl european white women hb gdl hb gdl find confirm elev hb concentr potenti indic iron overnutrit may play role pathophysiolog met metabol compon | D003920;D024821;D044343 | T047 |
36,235,660 | patern diet concept social determin elf cohort studi aim character patern diet peri concept period associ characterist cross section analys base father french nationwid elf birth cohort recruit father diet mother pregnanc assess item food frequenc questionnair six exploratori dietari pattern identifi princip compon analysi divers diet balanc alcohol snack bread chees process product older age relat higher score balanc alcohol snack pattern high educ level high score balanc pattern low score process product pattern unemploy first child relat high score alcohol pattern smoke posit relat alcohol process product pattern restrict diet associ high score balanc process product pattern low score alcohol snack bread chees pattern matern dietari pattern identifi previous analysi moder posit relat similar pattern among father find import screen father risk suboptim diet account factor futur studi examin specif influenc patern diet child health develop | D005220;D064890 | T099;T067;T033 |
36,235,659 | effect matern gut microbiota target therapi program nonalcohol fatti liver diseas dam fetus relat prenat high fat diet metabol disord start utero matern transmiss metabol phenotyp may increas risk advers metabol outcom nonalcohol fatti liver diseas nafld effect intervent essenti prevent gut microbiom play crucial role fat storag energi metabol nafld investig therapeut use probiot lactobacillus reuteri postbiot butyr gestat prevent perinat high fat diet induc program hepat steatosi offspr pregnant spragu dawley rat receiv regular chow high fat hf diet week mate l reuteri sodium butyr administ via oral gavag gestat rat sacrific day gestat treatment improv liver steatosi pregnant dam l reuteri superior effect l reuteri amelior obes alter metabol profil obes gravid dam matern l reuteri therapi prevent matern hf diet induc fetal liver steatosi reform placent remodel oxid injuri probiot therapi restor lipid dysmetabol fetal liver modul nutrient sens molecul placenta mediat short chain fatti acid signal cascad therapeut effect matern l reuteri matern nafld nafld reprogram offspr valid clinic translat | D000069196;D065626 | T007;T001;T047 |
36,235,658 | dietari pattern gut microbiota chang inflammatori bowel diseas current insight futur challeng inflammatori bowel diseas ibd result complex interplay gene host immun respons gut microbiota environment factor one crucial environment factor diet play pivot role modul gut microbiota communiti develop ibd review present overview dietari pattern involv pathogenesi manag ibd analyz associ gut microbi alter western diet rich protein fat refin carbohydr tend caus dysbiosi promot ibd progress dietari pattern found effect obtain ibd clinic remiss includ crohn diseas exclus diet cded mediterranean diet md anti inflammatori diet aid low ferment oligo di mono saccharid polyol fodmap diet specif carbohydr diet scd plant base diet etc overal mani research report role diet regul gut microbiota ibd diseas cours howev prospect studi requir achiev consist solid conclus futur review provid recommend studi explor novel potenti dietari strategi prevent ibd | D038441;D000069196;D015212 | T007;T061;T047;T001 |
36,235,657 | work home covid pandem effect diet sedentari lifestyl stress mani compani switch work home wfh covid pandem paper aim examin chang dietari behavior bodi weight sedentari lifestyl stress individu practic wfh cross section web base questionnair administ march may includ socio demograph characterist anthropometr measur wfh arrang chang diet sedentari lifestyl stress status total individu women men age year bmi kgm particip studi questionnair reveal daili work time increas wfh major individu gain weight averag daili sedentari time perceiv stress scale score increas signific daili sedentari time non healthi diet index score higher individu gain weight p lt multinomin regress model reveal increas bodi weight less like individu underweight normal bmi classif normal bmi stabl work shift physic activ posit predictor gain weight result suggest wfh may signific negat effect physic mental status individu | D000086382;D057185 | T047;T067;T079;T033 |
36,235,656 | nutrit play role amelior digit eye strain digit eye strain complex multifactori condit caus excess screen time exposur various electron devic smartphon tablet e reader comput current literatur suggest oxid damag concomit chronic pro inflammatori state repres signific etiopathogen mechan present review aim discuss potenti dietari role micronutri nutraceut properti amelior various ocular vision relat symptom associ digit eye strain ocular surfac dysfunct enhanc anti inflammatori benefit omega polyunsatur fatti acid well document treatment dri eye diseas anti oxid immunosuppress properti anthocyanin phytochem may also confer protect effect visual induc cognit stress digit asthenopia meanwhil nutraceut strategi involv xanthophyl macular carotenoid demonstr enhanc cognit function overal visual perform aid digit eye strain collect preliminari find seem offer strong line evid substanti need addit random control trial aim treat digit eye strain adjunct nutraceut strategi rct comparison commerci avail nutrit supplement need quantifi clinic benefit | D001248;D015352;D015525 | T047;T121;T109;T123;T184 |
36,235,655 | oral branch chain amino acid supplement athlet systemat review branch chain amino acid bcaa oxid muscl result stimul anabol signal return may optim perform bodi composit recoveri meanwhil among athlet evid bcaa supplement clear aim studi review effect bcaa athlet popul research conduct three databas web scienc databas pubm scopus inclus criteria involv particip classifi athlet peopl train regular oral supplement bcaa risk bias individu assess studi use revis cochran risk bias tool random trial rob record found studi met inclus criteria although bcaa tend activ anabol signal benefit perform bodi composit neglig hand studi includ resist particip show bcaa attenu muscl sore exercis endur sport find inconsist protocol bcaa supplement differ consider studi moreov studi report total protein intak across day consequ benefit bcaa interpret caution | D000597;D056352 | T098;T097;T123;T116 |
36,235,654 | chang eat behavior follow tast educ intervent focus children without neurodevelopment disord famili random control trial fussi eat children often display problemat behavior around mealtim irrit opposit may even throw tantrum may lead reduc food varieti poor nutrit profil may increas parent worri children diet particular children also neurodevelopment disord nd autism spectrum disord asd attent deficithyperact disord adhd investig effect tast educ problemat mealtim behavior children age year nd n without n parent particip week tast educ intervent children match age sex nd alloc random immedi intervent delay intervent group parent complet meal household questionnair mioh examin chang mioh score repeat measur analysi varianc time point use condit factor immedi intervent delay intervent baselin measur adjust robust linear mix model fit result show superior outcom intervent compar wait measur mioh stabl effect six month follow differ non signific children without nd tast educ program suggest promis simpl non intrus way reduc children problemat mealtim behavior long term | D000067877 | T048 |
36,235,653 | bodi mass index risk covid relat hospit adult age older europ higher bodi mass index bmi associ higher risk sever covid outcom aim studi investig associ among bmi under health condit hospit admiss well effect covid vaccin adult age year older europ use data survey health age retir europ share collect june august short second wave covid pandem occur europ survey data total individu use statist analys calcul likelihood hospit due covid infect relat bmi sociodemograph factor comorbid covid vaccin status approxim individu test posit covid hospit covid hospit individu either overweight obes likelihood hospit individu obes approxim time ci higher healthi weight bmi kgm adjust bmi sex age adjust sociodemograph factor vaccin comorbid likelihood hospit individu obes time higher healthi weight ci vaccin uptak lowest individu obes bmi kgm age group individu receiv vaccin time like hospit ci across european region obes associ higher odd hospit vaccin may effect reduc odd older adult | D000086382 | T047;T067 |
36,235,652 | trimest specif serum fructosamin associ abdomin adipos insulin resist inflamm healthi pregnant individu studi aim character variat serum fructosamin across trimest accord pre pregnanc bmi ppbmi examin associ fructosamin adipositymetabol marker ppbmi first trimest adipos leptin glucos homeostasi inflamm measur pregnanc serum fructosamin albumin fast glucos insulin leptin adiponectin interleukin il c reactiv protein crp concentr measur trimest first trimest subcutan sat viscer vat adipos tissu thick estim ultrasound healthi pregnant individu includ age yo ppbmi kgm fructosamin concentr decreas pregnanc wherea albumin correct fructosamin concentr increas p lt notabl fructosamin concentr invers associ ppbmi first trimest sat vat leptin r r r r respect p lt first trimest fast insulin homa ir r r p lt first trimest il r p lt howev correct albumin correl lost strength adjust ppbmi fructosamin concentr posit associ third trimest fast glucos crp r r p lt conclus serum fructosamin invers associ adipos pregnanc marker glucos homeostasi inflamm latter associ partial influenc albumin concentr ppbmi | D007333 | T046 |
36,235,651 | potenti modul inflamm probiot omega supplement elder chronic low grade inflamm random placebo control trial probiot omega supplement shown reduc inflamm dual supplement may synergist health effect investig novel combin multi strain probiot contain b lacti bi l paracasei lpc l acidophilus ncfm b lacti bl alongsid omega supplement reduc low grade inflamm measur high sensit c reactiv protein hs crp elder particip proof concept random placebo control parallel studi nct case communiti dwell elder particip median year iqr underw intervent dual supplement n placebo n eight week addit hs crp cytokin level intestin permeabl also assess baselin eight week intervent signific differ seen hs crp dual supplement group placebo howev interest supplement result signific increas level anti inflammatori marker il addit dual supplement increas level valer acid suggest potenti supplement reduc inflamm confer health benefit togeth result suggest probiot omega dual supplement exert modest effect inflamm may potenti use non pharmacolog treatment low grade inflamm elder | D015525;D019936 | T121;T007;T109;T123 |
36,235,650 | effect school base nutrit health educ rural chines children nutrit status rural chines children improv recent year nutrit knowledg still relat lack school base nutrit health educ conduct children three counti china student intervent school given two year nutrit health educ cours control school receiv intervent student nutrit knowledg dietari intak dietari behavior collect use questionnair height weight measur uniform nutrit knowledg score intervent group increas point first second year multilevel model use evalu intervent effect statist signific interact group time observ nutrit knowledg frequenc eat breakfast dietari intak includ meat egg milk veget p lt nutrit status therefor supplement school base nutrit health educ posit impact nutrit knowledg dietari intak rural chines children | D009752;D012574 | T092;T073;T033 |
36,235,649 | develop valid vietnames children short dietari questionnair evalu food group intak dietari practic among year old children urban vietnam studi aim develop assess reproduc valid vietnames children short dietari questionnair vcsdq evalu food group intak dietari practic among school age children year old urban vietnam item questionnair cover frequenc intak five core food group five non core food group five dietari practic week daili intak fruit veget water develop children n four primari school four area ho chi minh citi vietnam complet vcsdq twice well three consecut h recal week intra class correl spearman correl weight kappa cross classif bland altman plot use evalu reproduc valid direct valid food group vcsdq h recal examin use wilcoxon test trend vcsdq good reproduc group item icc rang grain eat watch screen vcsdq low relat valid two item instant noodl eat watch screen moder good agreement k k good direct valid three core food group fruit veget dairi three non core food group sweeten beverag instant noodl process meat addit vcsdq also use classifi daili intak fruit veget low high | D014675;D014867 | T121;T168;T197 |
36,235,648 | intermitt fast healthi dietari pattern diabet nephropathi diabet nephropathi dn metabol diseas character sever system metabol disord uniqu dietari pattern intermitt fast shown promis protect effect various metabol diseas diabet cardiovascular nervous system diseas howev role regul kidney diseas especi dn still investig summar current research progress highlight relationship risk factor progress dn discuss potenti mechan improv renal injuri dn final propos potenti strategi prevent delay dn progress abbrevi dn diabet nephropathi intermitt fast cpta carnitin palmitoyltransferas l fabp liver type fatti acid bind protein stz streptozotocin ldl low densiti lipoprotein hiit high intens interv train ckd chronic kidney diseas acei angiotensin convert enzym inhibitor arb angiotensin receptor blocker mda malondialdehyd mtdna mitochondri dna ucp uncoupl protein mam mitochondria associ endoplasm reticulum membran pbmcs peripher blood mononuclear cell erk extracellular signal regul kinas drp dynamin relat protein hb hydroxybutyr acac acetoacet geo gene express omnibus ncbi nation center biotechnolog inform mtorc mechanist target rapamycin complex hmgcs hydroxi methylglutaryl coa synthas gsk glycogen synthas kinas aki acut kidney injuri cma chaperon mediat autophagi fgf fibroblast growth factor | D003928;D005215 | T055;T047;T033 |
36,235,647 | nutrit behavior physic activ middl age older adult saudi arabia peopl get older nutrit status deterior result increas vulner chronic diseas adopt healthi lifestyl link improv health throughout age process current studi aim assess nutrit behavior dietari pattern physic activ among middl age older adult saudi arabia electron questionnair complet septemb novemb particip age year older report nutrit import state consum healthi diet particip report consum averag around servingsweek fruit veget mean intak score respect report around servingsweek red meat servingsweek poultri servingweek fish consum mean intak score respect particip report inact middl age older adult live saudi arabia poor dietari pattern nutrit behavior educ guidanc nutrit need popul help improv diet lifestyl | D004032;D014675 | T168 |
36,235,646 | link low densiti lipoprotein cholesterol ldl level arsenic acid dimethylarsin monomethylarson result nation popul base studi nhane arsenic contamin global public health problem elev total cholesterol tc low densiti lipoprotein cholesterol ldl c risk factor cardiovascular diseas data associ urinari arsenic speci level ldl c limit perform associ analysi base urinari arsenic speci blood tc ldl c us adult method urinari arsenic arsenic acid aa dimethylarsin dma monomethylarson mma tc ldl c key covari obtain avail nation health nutrit examin survey nhane data multipl linear regress analysi general linear model use analyz linear nonlinear relationship respect result total adult age year enrol analysi median total urinari arsenic level gl posit associ urinari arsenic concentr quartil observ tc ci tc particip th versus th percentil urinari total arsenic ci ldl c particip th versus th percentil urinari total arsenic ci speciat arsenic analysi arsenic acid tc ci wherea dma ldl l ci mma ldl l ci conclus urinari arsenic arsenic speci posit associ increas ldl c concentr prevent exposur arsenic arsenic speci mayb help control tc ldl c level adult | D001151 | T121;T131;T196 |
36,235,645 | associ viscer fat area hyperuricemia non obes us adult cross section studi studi aim investig relationship viscer fat area vfa hyperuricemia hua among non obes adult extract data us adult age year nation health nutrit examin survey nhane vfa divid four quartil q q use multivari logist regress model control known confound general addit model gam restrict cubic spine use examin associ vfa hua stratifi sex two piecewis linear regress model use calcul threshold effect among male result reveal preval hua men women fulli adjust model posit associ vfa hua quartil variabl q vs q odd ratio confid interv ci p lt p trend lt continu variabl per cm increment ci p lt besid posit associ remain signific stratifi sex interest observ nonlinear dose respons relationship vfa hua male inflect point cm conclus studi confirm signific posit relationship vfa hua among non obes adult remain statist signific stratifi sex | D033461 | T047 |
36,235,644 | butyr glycerid protect intestin inflamm barrier dysfunct mice studi investig attenu effect butyr glycerid bg intestin inflammatori respons barrier dysfunct induc lps stimul initi dose respons test carri identifi optim dose bg test mice given intragastr administr bg differ dose follow lipopolysaccharid lps intraperiton inject small intestin morpholog cytokin mrna express measur gkg bw bg administr possibl allevi injuri duoden morpholog attenu ileum villus height reduct promot il mrna express therefor optim dosag gkg bw bg select main experi ultrastructur imag jejunum ileum epitheli cell mrna express level cytokin immunofluoresc ileum analyz result show bg maintain ileac brush border tight junction structur protein express bg attenu increas inflammatori cytokin tlr jnk mrna express taken togeth gkg bw bg administr maintain intestin barrier function reduc intestin bodi inflamm respons induc lps mice mechan bg allevi intestin inflammatori respons maintain intestin barrier function may relat jnk signal pathway | D016753;D008070 | T109;T116;T129 |
36,235,643 | snps lncrna kcnqot modul express confer suscept salt sensit blood pressur chines han popul long noncod rna lncrna play import role cardiovascular diseas involv lncrna salt sensit blood pressur ssbp well known aim explor associ sixteen singl nucleotid polymorph snps five lncrna gene kcnqot lnc agap lnc igsf etc express suscept ssbp two stage associ studi conduct among individu quantifi express lncrna detect use real time pcr genotyp accomplish use massarray system express quantit trait loci test general linear model util explor function snps one sampl mendelian random use studi causal relationship kcnqot ssbp signific effect observ kcnqot express ssbp phenotyp p lt rs rs kcnqot may influenc secondari structur mirna bind express kcnqot rs rs kcnqot identifi associ one ssbp phenotyp multipl test correct may mediat kcnqot one sampl mendelian random analys show causal associ kcnqot ssbp find suggest rs rs might associ lower risk ssbp influenc kcnqot secondari structur mirna bind result chang kcnqot express | D006973;D035683;D062085 | T047;T123;T114 |
36,235,642 | relationship mental health emot eat covid pandem systemat review obes one danger epidem st centuri covid pandem began caus mani death among patient obes without complic simultan lockdown relat covid pandem caus host emot problem includ anxieti depress sleep disturb mani peopl began cope emot increas food emot eat alcohol consumpt combin decreas physic activ promot develop overweight obes emot eat also known stress eat defin propens eat respons posit negat emot physic need note emot eat may first step develop bing eat disord extrem subtyp food addict interest post bariatr surgeri patient increas frequenc addict disord observ exampl food addict replac alcohol addict call cross addict addict transfer data indic obes treat psychosomat diseas develop extern factor caus format negat emot may play signific role current one factor covid pandem manuscript discuss relationship covid pandem develop emot eat well potenti implic viral pandem obes pandem need chang approach treatment obes futur | D000086382;D001068 | T047;T067;T048 |
36,235,641 | myo inositol moder glucos induc effect human placent c arachidon acid metabol matern hyperglycemia associ disrupt transplacent arachidon acid aa suppli eicosanoid synthesi contribut advers pregnanc outcom sinc placent inositol lower increas glycemia sinc myo inositol appear promis intervent gestat diabet hypothes myo inositol might rectifi glucos induc perturb placent aa metabol term placent explant n women underw mid gestat oral glucos toler test cultur c aa h media contain glucos mm myo inositol newli synthes c aa lipid quantifi liquid chromatographi mass spectrometri increas matern fast glycemia associ decreas proport c aa phosphatidyl ethanolamin pe pe p increas proport c aa triacylglycerid tgs relat total placent c aa lipid suggest alter placent aa compartment toward storag away pool util eicosanoid product fetal aa suppli compar control mm glucos mm glucos treatment decreas amount four c aa phospholipid eleven c aa tgs whilst mm glucos increas c aa pc c aa lpc glucos induc alter c aa lipid except pe p attenu concurr myo inositol treatment myo inositol therefor rectifi glucos induc effect studi requir determin matern myo inositol supplement could reduc aa associ pregnanc complic | D016640;D010920 | T018;T047 |
36,235,640 | obes relat dietari pattern associ higher risk sleep disord cross section studi nhane evid associ dietari pattern sleep disord limit controversi addit studi evalu effect dietari pattern sleep disord seldom consid critic role obes aim explor obes relat dietari pattern evalu impact sleep disord use data nation health nutrit examin survey total particip age year two day dietari recal enrol obes relat dietari pattern explain varianc waist circumfer bmi simultan extract twenti six food group use partial least squar method sleep disord sleep durat defin self report question primari secondari outcom respect general linear model perform estim associ sleep disord sleep durat dietari pattern two type dietari pattern identifi high fat refin grain meat pattern character high intak solid fat cure meat potato refin grain meat chees ad sugar low whole grain veget fruit pattern character low intak oil whole grain nut seed milk fruit sever veget particip highest adher high fat refin grain meat pattern higher risk sleep disord ci shorter sleep durat ci compar lowest adher correspond associ low whole grain veget fruit pattern signific sleep durat ci result found dietari pattern character high solid fat cure meat potato refin grain meat chees ad sugar associ higher risk sleep disord shorter sleep durat | D004032;D012893 | T047;T168;T048 |
36,235,639 | effect import food sourc fructos contain sugar inflammatori biomark systemat review meta analysi control feed trial fructos contain sugar sugar sweeten beverag ssbs may increas inflammatori biomark whether effect mediat food matrix differ level energi unknown investig role food sourc energi conduct systemat review meta analysi control trial effect differ food sourc fructos contain sugar inflammatori marker differ level energi control | D005632;D015850 | T121;T109;T116;T129 |
36,235,638 | benefici effect anti inflammatori diet modul gut microbiota control obes obes consist associ increas risk metabol abnorm diabet hyperlipidemia cardiovascular diseas well develop sever type cancer recent decad unfortun rate overweightobes increas signific among adult children grow bodi evid show relationship metabol disord obes composit gut microbiota addit inflamm consid drive forc obes gut microbiota connect therefor seem anti inflammatori nutrient food andor diet play essenti role manag obes affect intestin flora control inflammatori respons review describ link gut microbiota obes inflamm summar benefit anti inflammatori diet prevent obes | D000069196;D008659 | T007;T001;T047 |
36,235,637 | lipid metabol cartilag develop degener regener lipid affect cartilag growth injuri regener divers way diet metabol becom increas import preval obes risen proper lipid supplement diet contribut preserv cartilag function wherea excess lipid buildup detriment cartilag lipid metabol pathway generat proinflammatori substanc crucial develop manag osteoarthr oa lipid metabol complic metabol process involv sever regulatori system lipid metabolit influenc differ featur cartilag review examin current knowledg cartilag growth degener regener process well recent research signific lipid metabol cartilag includ extracellular matrix chondrocyt depth examin involv lipid metabol cartilag metabol provid insight cartilag metabol lead develop new treatment techniqu metabol cartilag damag | D002358 | T024 |
36,235,636 | impact obes cours manag inflammatori bowel diseas review alreadi well known viscer adipos tissu insepar relat pathogenesi activ general outcom inflammatori bowel diseas ibd get closer closer molecular background loop find certain relationship activ mesenter tissu inflamm within lumen gastrointestin tract recent relat new data uncov indic direct impact bodi fat pattern pharmacolog treatment cours ibd hand ileal colon type crohn diseas ulcer coliti appear diversifi thought past howev question aris whether stage abl translat knowledg practic manag ibd patient still explor scientif background patholog specif tool use direct patient review explor ibd context obes associ disord focus adipokin creep fat possibl relationship disord treatment ibd patient | D003424;D015212;D009765 | T047 |
36,235,635 | accumul advanc glycat end product bodi dietari habit format advanc glycat end product age tissu physiolog process howev excess product storag patholog lead inflamm sedentari lifestyl hypercalor high fructos diet increas intak process food element contribut excess product compound creat non enzymat multi stage glycat process age sourc endogen exogen main due process food high temperatur low moistur includ grill roast fri accumul age increas oxid stress initi various disord lead progress atherosclerosi cardiovascular diseas diabet complic inborn defens mechan recoveri system exogen antioxid includ polyphenol protect excess age accumul addit numer product anti glycat properti occur main fruit veget herb spice confirm role diet prevent civil diseas | D004032;D017127 | T109;T168;T123 |
36,235,634 | measur energi expenditur use indirect calorimetri post intens care unit hospit survivor comparison predict equat actual energi need stay intens care unit icus unknown aim observ studi measur energi expenditur mee icu survivor post icu hospit period compar estim predict equat eee survivor icu stay day enrol general ward first day icu discharg ee measur use q nrg calorimet canopi mode measur compar estim ee use harri benedict hb equat multipli stress factor penn state ps equat kcal weight base wb equat total adult includ male age bodi mass index kgm indirect calorimetri perform icu stay mee kcald correspond kcalkgday eee valu deriv use hb wb equat signific higher mee kcald respect p lt signific differ mee eee use ps equat kcald p ps equat tend underestim mee bias kcal wide limit agreement kcal use ps equat agreement within mee found patient present cohort patient surviv prolong icu stay mee around kcalkgday post icu hospit context none test equat accur predict ee measur indirect calorimetri | D004734;D007362 | T093;T073;T040;T039 |
36,235,633 | explor activ ingredi benefici effect potenti mechan allium tenuissimum l flower treat tdm mice base network pharmacolog gut microbiota forti compound isol character tenuissimum flower among twelv flavonoid show higher glucosidas inhibit activ vitro acarbos especi kaempferol molecular dock result show bind kaempferol glucosidas gaa could reduc hydrolysi substrat gaa reduc glucos produc hydrolysi thus exhibit glucosidas inhibit activ vivo experi result show flavonoid rich tenuissimum flower could decreas blood glucos reduc lipid accumul protein express level rac alpha serinethreonin protein kinas akt peroxisom prolifer activ receptor gamma pparg prostaglandin gh synthas ptgs liver tissu increas addit firmicutesbacteroidet fb ratio increas level gut probiot bifidobacterium increas level enterobacteriacea staphylococcus decreas carbohydr metabol lipid metabol pathway relat type diabet mellitus activ studi indic flavonoid rich tenuissimum flower could improv glycolipid metabol disord inflamm diabet mice modul protein express gut microbiota | D000490;D003921;D003924;D000069196 | T050;T047;T002;T007;T001 |
36,235,632 | suppress effect turmer extract muscl atrophi dexamethason treat mice myotub sarcopenia declin skelet muscl mass strength function decreas qualiti life elder peopl studi investig suppress effect turmer curcuma longa extract te muscl atrophi dexamethason dex treat mice cc myotub dex treatment signific decreas muscl weight signific increas fbxo murf express mice chang suppress supplement base diet te similar pattern observ fbxo murf protein express cc myotub dex treatment signific increas fbxo murf gene protein express increas signific suppress te supplement concentr gml furthermor one five te fraction separ high perform liquid chromatographi similar effect te supplement present studi propos suppress effect turmer sarcopenia | D030024;D055948 | T047;T168;T002 |
36,235,631 | monotropein protect inflammatori bone loss suppress osteoclast format bone resorpt inhibit nfatc via nf b aktgsk pathway monotropein mon kind iridoid glycosid plant secondari metabolit primarili present edibl medicin plant aim studi investig effect mon lipopolysaccharid lps induc inflammatori bone loss mice osteoclast oc deriv bone marrow deriv macrophag bmms explor mechan under effect mon lps induc osteoclastogenesi found mon mark attenu deterior bone micro architectur enhanc tissu miner content tmc bone volumetot volum bvtv reduc structur model index smi trabecular separationspac tbsp bone tissu decreas activ tartrat resist acid phosphatas b tracp b receptor activ nf b rank receptor activ nf b ligand rankl well serum level interleukin il interleukin il lps treat mice addit mon treatment reduc number trap posit oc bone tissu lps treat mice also exert stronger inhibitori effect format differenti f actin ring construct oc deriv bmms mon signific inhibit express nuclear factor activ cell c nfatc immedi earli gene c fos nuclear transloc nfatc lps treat oc therebi inhibit express matrix metalloproteinas mmp cathepsin k ctsk trap mon signific inhibit express traf phosphoryl p degrad ikb thus inhibit activ nf b pathway lps induc inflammatori mice oc deriv bmms also inhibit lps induc phosphoryl protein kinas b akt glycogen synthas kinas gsk oc deriv bmms conclus result suggest mon could effect inhibit osteoclastogenesi vitro vivo therefor may prove potenti option prevent treatment osteoclast bone resorpt relat diseas | D001862;D010010 | T025;T042 |
36,235,630 | twelv month time restrict feed improv cognit alter microbiom composit independ macronutri composit declin health gut dysbiosi cognit impair hallmark advanc age calor restrict known robust extend healthspan alter gut microbiom composit difficult maintain time restrict feed chang dietari macronutri composit could feasibl altern enhanc late life cognit physic health easier compli extend period time investig possibl month old rat place time restrict feed ketogen micronutri calor match control diet month third group rat permit eat standard chow ad libitum time month rat test bicondit associ task fecal sampl collect microbiom composit analysi regardless dietari composit time restrict fed rat better cognit perform ad libitum fed rat observ could account differ motiv procedur sensorimotor impair addit signific differ gut microbiom divers composit diet condit allobaculum abund associ cognit task perform indic link gut health cognit outcom age subject overal time restrict feed largest influenc cognit perform age rat | D005215;D000069196 | T007;T055;T001;T033 |
36,235,629 | supplement queen bee larva powder extend longev caenorhabd elegan queen bee larva qbl one kind import edibl insect harvest royal jelli product process qbl mani physiolog function howev limit inform avail regard antiag effect studi antiag function freez dri qbl powder qblp investig combin caenorhabd elegan c elegan model transcriptom administr qblp c elegan shown improv lifespan paramet addit qblp improv mobil nematod transcriptom analysi show differenti express gene deg signific enrich gene ontolog go term almost relat biolog function cell metabol stress associ lifespan kyoto encyclopedia gene genom kegg analysi suggest lifespan c elegan relat longev regul pathway worm express level key gene sod gst hsp lip in lip upregul sod hsp lip lip downstream target daf import transcript factor relat lifespan extens cf daf mu supplement qblp show life prolong indic antiag function qblp close relat daf thus qblp compon could potenti use function materi amelior age age relat symptom | D017173;D029742 | T116;T204 |
36,235,628 | acut effect singl dose molecular hydrogen supplement respons ergogen adjust high intens intermitt exercis human research examin effect singl dose molecular hydrogen h supplement acid base status local muscl deoxygen rest high intens intermitt train hiit perform recoveri ten healthi train subject random doubl blind crossov design receiv h rich calcium powder hcp mg contain g h h deplet placebo mg supplement h pre exercis perform six bout pedal hiit bodi weight separ pedal interv follow recoveri period blood gase ph pco hco concentr measur rest muscl deoxygen deoxi hb mb tissu satur determin via time resolv near infrar spectroscopi vastus laterali vl rectus femori rf muscl rest recoveri rest hcp group signific higher pco hco concentr slight tendenc toward acidosi exercis first hiit bout peak power signific higher hcp w vs placebo w p hcp notabl effect signific increas deoxi hb mb concentr hiit exercis despit differ heart rate respons hcp group show signific greater extract vl microvascular hb volum rf hiit exercis hiit exercis provid signific improv blood flow muscl reoxygen rate rf vl passiv recoveri compar rest group hcp supplement might exert ergogen effect high intens exercis prove advantag improv anaerob hiit exercis perform | D000072696;D058573 | T121;T056;T061;T039 |
36,235,627 | reproduc valid semi quantit food frequenc questionnair assess dietari intak vegetarian omnivor harbin china studi aim evalu reproduc valid semi quantit food frequenc questionnair sqffq develop vegetarian omnivor harbin china particip vegetarian omnivor administ sqffq baselin sqffq six month later sqffq assess reproduc h recal hrs three consecut day complet administr two sqffqs determin valid reproduc pearson correl coeffici sqffq sqffq vegetarian omnivor respect valid unadjust pearson correl coeffici averag averag respect energi adjust pearson correl coeffici averag averag respect major correl coeffici food group macronutri decreas remain unchang energi adjust furthermor correl statist signific p lt bland altman plot also show reason accept agreement two method conclus sqffq develop studi reason accept reproduc valid | D004435;D002149 | T038;T081;T040;T033 |
36,235,626 | cross section associ blood selenium glycem biomark among us adult normoglycemia nation health nutrit examin survey selenium se remain inconsist relationship glycem biomark risk develop type diabet td studi investig relationship blood se glycem biomark among peopl normoglycemia conduct cross section analysi use us nation health nutrit examin survey multivari linear regress model develop examin associ blood se glycem biomark name fast plasma glucos fpg hemoglobin ac hbac insulin oral glucos toler test ogtt blood se treat continu per log increment categor exposur quartil separ regress model assess dose respons relationship restrict cubic spline analysi exclud particip td incomplet data particip analyz highest quartil blood se associ increas fpg adjust confid interv ci ogtt adjust ci hbac adjust ci insulin adjust ci compar lowest quartil posit associ also observ everi log increment blood se level glycem biomark except ogtt posit linear dose respons relationship exist blood se fpg p overal p nonlinear insulin p overal p nonlinear bmi age smoke status modifi associ highest quartil se compar lowest quartil glycem biomark overal posit associ blood se glycem biomark observ among us adult normoglycemia find impli peopl normoglycemia need awar level se miner intak diet supplement research requir identifi mechan excess se progress diabet | D003924;D012643 | T121;T047;T123;T196 |
36,235,625 | nudg finnish adult replac red meat plant base protein via present food dish day alter dish sequenc studi investig whether finnish work age omnivor n could nudg replac red meat fava bean base protein sourc via dish day dod main dish sequenc alter sa strategi control real world finnish self servic buffet restaur smart scale flavoria multidisciplinari research platform aim studi whether effect strategi differ gender age bodi mass index particip assign one four experiment treatment standard menu dod standard menu sa dod sa particip could choos amount combin salad compon casserol minc meat fava bean protein subject dod menu andor sa effect main dish choic share meat base dish meal weight men like choos meat base main dish higher share meat dish meal weight compar women differ observ age year normal weight overweight obes futur studi larger sampl size investig food choic motiv price environment awar | D002755;D005247;D014674;D000069466 | T116;T055;T123;T040;T168 |
36,235,624 | impact preoper viscer fat area measur bioelectr imped analysi clinic oncolog outcom colorect cancer studi shown increas viscer fat associ postop clinic oncolog outcom howev studi use bioelectr imped analysi bia determin effect viscer fat oncolog outcom colorect cancer crc studi aim investig impact preoper viscer fat area measur bioelectr imped analysi clinic oncolog outcom colorect cancer method studi includ patient underw anthropometr measur bia surgic treatment crc januari june | D015179;D050152 | T191;T024 |
36,235,623 | effect alpha glycerylphosphorylcholin heart rate variabl hemodynam variabl follow sprint interv exercis overweight obes women current studi examin effect alpha glycerylphosphorylcholin gpc heart rate variabl hrv hemodynam respons follow sprint interv exercis sie women overweight obes particip n year kgm consum mg gpc placebo eat breakfast random doubl blind cross design min particip perform two bout sie wingat interspers min activ recoveri rpm hemodynam variabl hrv domain measur min gpc consumpt immedi sie everi min min recoveri gpc consumpt increas rest level time domain standard deviat rr wave interv sdnn percentag interv differ adjac rr interv greater ms pnn frequenc domain high frequenc hf low frequenc lf variabl hrv p lt moreov hrv variabl except lfhf decreas p lt immedi sie gpc placebo session systol diastol blood pressur increas p lt immedi sie trial hrv hemodynam variabl recov p lt faster gpc compar placebo session conclud gpc consumpt recov hrv blood pressur faster follow strenuous exercis overweight obes women might favor modifi cardiac autonom function | D005997;D050177 | T109;T123;T033 |
36,235,622 | gut microbi metabolom realli matter connect gut metabolom neurolog disord herein gather updat knowledg regard alter gut microbiota dysbiosi correl human neurodegen brain relat diseas eg alzheim parkinson review underlin import gut deriv metabolit gut metabol status main player gut brain crosstalk implic sever neural condit scientif evid indic administr probiot bacteria exert benefici protect effect reduc system inflamm neuroinflamm inhibit neurodegener experiment result perform anim also human clinic trial show import design novel microbiota base probiot dietari supplement aim prevent eas symptom alzheim parkinson diseas form dementia neurodegener | D000544;D000069196;D009422;D010300;D019936 | T007;T001;T047;T048 |
36,235,621 | melatonin prevent chondrocyt matrix degrad rat experiment induc osteoarthr inhibit nuclear factor b via sirt osteoarthr oa common degen joint diseas character imbal cartilag extracellular matrix ecm breakdown anabol melatonin mt one hormon secret pineal gland brain anti inflammatori antioxid anti age function explor role mt rat establish oa model rat anterior cruciat ligament transect aclt safranin fast green stain show intraperiton inject mt mgkg could allevi degener articular cartilag aclt rat immunohistochem ihc analysi found mt could regul express level collagen type ii aggrecan inhibit express level matrix metalloproteinas mmp matrix metalloproteinas mmp adam metallopeptidas thrombospondin type motif adamt aclt rat elucid mechan mt protect ecm inflammatori factor induc rat chondrocyt conduct vitro experi co cultur mt cultur medium western blot wb show mt could promot express level transform growth factor beta tgf smad famili member smad sirtuin relat enzym sirt inhibit express level phosphoryl nuclear factor kappa light polypeptid gene enhanc b cell inhibi tor p p phosphoryl ib kinas p ib addit wb real time pcr qrt pcr result show mt could inhibit express level mmp mmp adamt induc nitric oxid synthas ino cyclooxygenas cox chondrocyt induc interleukin il regul express chondroprotect protein type ii collagen found vivo mt treatment protect articular cartilag rat aclt model il induc rat chondrocyt mt could reduc chondrocyt matrix degrad regul nuclear factor kb nf b signal pathway depend express sirt protect chondrocyt activ tgf smad pathway | D002358;D008550;D010003 | T047;T121;T109;T024;T125 |
36,235,620 | nutrit imbal polish children coeliac diseas strict gluten free diet current treatment coeliac diseas cd strict lifelong gluten free diet gfd howev complet regard energi macro micronutri remain poor understood paediatr studi often limit low qualiti lack control find interpret caution aim present studi evalu nutrit imbal children cd strict gfd | D002446;D055050 | T061;T047 |
36,235,619 | exercis train attenu hypertens via suppress rosmapknf bat r pathway hypothalam paraventricular nucleus aerob exercis train ext benefici hypertens howev central mechan improv hypertens remain unclear sinc import regul angiotensin ii type receptor r paraventricular nucleus pvn hypothalam sympathoexcit hypertens shown testifi hypothesi aerob ext decreas blood pressur hypertens rat regul r reactiv oxygen speci ros mitogen activ protein kinas mapk nuclear factor b nf b pathway within pvn | D006973;D010286;D010805 | T038;T047;T023 |
36,235,618 | intak antioxid capac children depend health status gastrointestin digest food gut microbi activ render myriad differ molecul could respons biolog activ classic assign parent compound previous shown phytochem whose antioxid capac either increas decreas metabol gut microb whether global antioxid capac extract food determin gut microbi communiti structur still well describ present studi vitro digest ferment differ food submit differ culinari treatment use stool lean children obes children celiac children children allergi cow milk protein antioxid capac assess dpph frap assay percentag food contribut daili antioxid intak well antioxid capac portion size infer overal cereal fruit veget display higher contribut daili antioxid intak tuber fish meat exhibit higher antioxid capac serv size food ferment lean children children allerg cow milk protein fecal materi show higher antioxid capac could impli larger role gut microbiota area | D016269;D063766 | T047;T046;T033 |
36,235,617 | trimethylamin n oxid tmao indoxyl sulfat concentr patient alcohol use disord trimethylamin n oxid tmao indoxyl sulfat produc microbiota liver contribut brain age impair cognit function studi aim examin serum tmao concentr patient alcohol use disord aud entri alcohol withdraw relationship sever biolog neuropsycholog clinic paramet | D000437;D013375 | T184;T048 |
36,235,616 | pandanus amaryllifolius exhibit vitro anti amyloidogen activ promot neuroprotect effect amyloid induc sh syy cell accumul amyloid beta plaqu lead oxid stress mitochondri damag cell death one accept patholog hallmark alzheim diseas ad pandanus amaryllifolius common recogn fragrant screw pine due characterist smell wide distribut southeast asia consum food flavor search potenti anti ad agent terrestri sourc p amaryllifolius explor vitro anti amyloidogen neuroprotect effect thioflavin tht assay high throughput screen multim detect system mds hts assay use evalu extract potenti inhibit aggreg oligomer respect crude alcohol extract cae gml crude base extract cbe gml obstruct aggreg interest result reveal cbe inhibit nucleat gml cae cbe also restor cell viabil reduc level reactiv oxygen speci revers mitochondri dysfunct gml extract concentr insult sy syy cell addit unpreced isol nicotinamid p amaryllifolius cbe remark discoveri one potenti bioactiv constitu ad henc result provid new insight promis potenti p amaryllifolius extract ad explor prospect bioactiv constitu | D000544;D009447;D018696;D031673 | T047;T002;T191;T121;T048;T169 |
36,235,615 | singl vitamin bolus supplement improv vitamin status reduc proinflammatori cytokin healthi femal vitamin defici global health problem lead metabol bone diseas also mani ill associ chronic inflamm thus aim investig safeti effect singl high dose vitamin iu vitamin status proinflammatori cytokin interleukin il il tumor necrosi factor tnf healthi saudi femal fifti healthi femal recruit oral supplement singl vitamin bolus iu particip donat fast blood sampl baselin one day thirti day supplement serum hydroxyvitamin oh il il tnf calcium phosphat parathyroid hormon pth blood lipid level determin serum oh signific increas one thirti day supplement compar baselin without caus elev calcium phosphat decreas pth abnorm level contrast concentr three repres proinflammatori cytokin decreas gradual end studi period conclus singl high dose iu effect improv serum vitamin status reduc concentr proinflammatori cytokin rapid safe way healthi femal | D002762;D014808 | T121;T047;T109;T127 |
36,235,614 | communic abnorm metabol new born screen result netherland parent perspect netherland abnorm new born screen nbs result communic parent general practition gp good communic consequenti trust profession utmost import treatment phenylketonuria pku aim studi assess parent satisfact regard communic abnorm nbs result pku netherland email contain link web base questionnair sent dutch pku associ member respons open question categor data open close question analys descript statist chi squar test use spss parent child pku born state overal unsatisfi first communic nbs result seventi five parent indic wrong inform pku given signific decreas found number parent contact gp cours year p lt half parent overal unsatisfi first communic abnorm nbs result pku research optim communic abnorm nbs result necessari | D010661 | T047 |
36,235,613 | applic cluster techniqu multipl nutrit factor relat inflamm diseas progress patient inflammatori bowel diseas diet nutrit status affect intestin inflamm patient inflammatori bowel diseas ibd aim studi use cluster analysi assess structur similar differ group paramet includ short chain fatti acid scfa level stool well hematolog inflammatori paramet serum c reactiv protein crp proinflammatori anti inflammatori cytokin also assess similar ibd patient term various biochem featur diseas activ nutrit status total particip enrol includ patient ibd control identifi four main meaning cluster paramet first cluster includ scfas strong mutual correl second cluster contain red blood cell paramet albumin level third cluster includ proinflammatori paramet tumor necrosi factor crp platelet phosphor succin lactic acid final cluster reveal associ zonulin interleukin il il il moreov observ invers correl il bodi mass index find suggest link nutrit status diet inflammatori paramet patient ibd contribut better adjust nutrit treatment | D018450;D015212 | T047;T046;T033 |
36,235,612 | alter gut microbiota clinic relev mild cognit impair alzheim diseas shanghai age studi shanghai memori studi alter gut microbiota report individu mild cognit impair mci alzheim diseas ad previous research suggest specif bacteri speci might associ declin cognit function howev evid insuffici result inconsist determin whether alter gut microbiota patient mci ad investig correl clinic characterist fecal sampl cognit normal control nc particip mci patient ad collect analyz ribosom rna sequenc overal microbi composit specif taxa compar clinic relev analyz signific overal differ alpha beta divers among three group patient ad mci increas bacteri taxa includ erysipelatoclostridiacea erysipelotrichal patescibacteria saccharimonadal saccharimonadia compar nc group p lt posit correl apo carrier status clinic dementia rate correl coeffici p lt negat associ memori correl coeffici p lt result support hypothesi intestin microorgan chang mci ad alter specif taxa correl close clinic manifest indic potenti role ad pathogenesi | D000544;D060825;D000069196 | T007;T001;T047;T048 |
36,235,611 | realgar allevi neuroinflamm induc high protein high calori diet rat via microbiota gut brain axi gastrointestin heat retent syndrom ghrs often occur adolesc result nervous system injuri realgar arsenic miner neuroprotect effect wide use treat ghrs howev mechan action remain unknown | D001151;D064307;D018696 | T131;T028;T121;T001;T196;T169;T032 |
36,235,610 | link food environ colorect cancer systemat review food diet critic risk factor colorect cancer crc food environ fes contribut diseas risk includ crc review investig link fes crc incid mortal risk systemat search studi utilis three primari journal databas pubm scopus web scienc retriev citat screen data extract articl relat fe expos popul risk crc death evalu ecolog studi cohort studi qualiti assess newcastl ottawa qualiti assess form cohort studi respect descript synthesi includ studi perform articl identifi eight elig final review includ studi compris six ecolog studi two cohort studi publish six articl us one africa one switzerland eight studi good qualiti signific find crc incid associ avail specif food red meat meat anim fat energi anim sourc unhealthi fe increas crc mortal link avail anim fat red meat alcohol beverag calori food avail resid food desert lower fe index varieti associ crc fe avail specif food unhealthi fe food dessert impact crc incid mortal creat healthi fe futur requir focus thorough plan | D015179 | T191 |
36,235,609 | scope review urinari marker metabol matur preterm infant futur intervent improv growth background growth failur infant born preterm signific issu increas risk poorer neurodevelopment outcom metabol syndrom later life first day life biolog system matur rapid involv development program cellular senesc metabol matur regul normal growth develop howev littl known metabol matur infant born preterm relationship growth object examin avail evid urinari marker metabol matur relationship growth infant born preterm elig criteria studi includ scope review use qualit quantit method describ urinari marker metabol matur relationship growth infant born preterm result screen process titl includ review draw china n itali n germani n greec n japan n norway n portug n spain n usa n includ studi examin urinari metabolit infant content analysi identifi overarch theme relat metabol matur relat gestat age ii metabol signatur chang urinari metabolit time iii nutrit iv growth conclus result scope review suggest consider gap knowledg relat factor associ metabol instabl constitut normal matur preterm infant develop refer phenom age z score metabolit interest could improv nutrit growth outcom | D007234 | T100;T033 |
36,235,608 | sever food insecur among australian univers student profession academ staff assess sever food insecur within australian univers student lack experi food insecur australian univers staff unknown cross section onlin survey march aim character sever food insecur student profession academ staff univers tasmania uta household food secur survey modul six item short form assess food secur status addit seven demograph educ characterist student six demograph employ characterist staff particip categor high margin low low food secur multivari binari logist regress identifi student staff higher risk food insecur among student respond n preval food insecur compris margin low low food secur younger non binari first year enrol campus intern student signific higher risk food insecur among staff n food insecur compris margin low low food secur profession staff staff casual contract staff recent employ signific higher risk food insecur find suggest high occurr food insecur uta student staff larg proport food insecur staff student experienc low food secur find implic effort toward reduc food insecur univers campus holist integr approach advoc food system support healthi sustain equit food procur provis univers student staff | D005523;D013334 | T098;T081 |
36,235,607 | trimethylamin n oxid promot osteoclast differenti bone loss via activ ros depend nf b signal pathway trimethylamin n oxid tmao import gut microbiota gm deriv metabolit shown abnorm increas osteoporosi howev role under mechan tmao regul bone loss osteoporosi fulli investig current studi found tmao dose depend enhanc trap posit osteoclast f actin ring format resorpt area bovin bone slice regul osteoclast relat gene express calcr traf dcstamp acp c fos nfatc western blot valid tmao activ nf b signal pathway also stimul c fos nfatc protein express dose depend manner furthermor bay nf b inhibitor pretreat mark suppress trap posit osteoclast format osteoclast relat gene tmao treatment bay also inhibit p pp c fos nfatc protein express promot tmao moreov tmao signific increas ros product inhibit n acetylcystein nac ros antagonist addit prove nac pretreat could inhibit tmao promot nf b activ nac also suppress trap posit osteoclast format osteoclast relat gene express protein express c fos nfatc tmao treatment vivo studi show signific decreas bone mass increas trap posit osteoclast tmao treat cbl mice moreov western blot immunohistochem stain show tmao administr mark stimul nf b p express addit tmao administr signific promot gene protein express c fos nfatc conclus tmao could promot osteoclast differenti induc bone loss mice activ ros depend nf b signal pathway | D001862;D010024 | T047;T042 |
36,235,606 | circul level short chain fatti acid pregnanc infant neurodevelop short chain fatti acid scfa play key role gut microbiota brain crosstalk regul main neurodevelopment process pregnanc aim studi investig longitudin relationship prenat level main scfas matern serum infant cognit develop tempera day postpartum adjust sever pre peri post natal confound | D058610;D011422 | T121;T109 |
36,235,605 | dietari behavior among new user meal kit servic earli month covid pandem covid pandem chang way peopl acquir food includ increas use meal kit deliveri servic investig analyz data nation survey us adult collect juli septemb describ new user meal kit servic pandem explor associ new use meal kit dietari behavior bivari multivari regress analys conduct identifi differ demograph characterist report dietari behavior new never meal kit user near new meal kit user age year live urban area report children household higher proport new user current snap particip compar never user compar never user new user meal kit servic report eat fruit veget pr ci red process meat pr ci sinc pandem began result suggest meal kit servic may use resourc certain popul earli month covid potenti associ increas consumpt certain food research examin continu use influenc meal kit servic diet need | D000086382 | T047;T067 |
36,235,604 | smoflipid impact growth neonat morbid preterm infant soybean oil medium chain triglycerid oliv oil fish oil lipid smoflipid increas use worldwid without definit evid benefit examin effect smoflipid growth veloc neonat morbid preterm infant preterm infant receiv soybean base lipid emuls januari compar receiv smoflipid januari neonat tertiari center linear regress analysi conduct analyz associ type lipid emuls growth veloc modifi log poisson regress general linear model robust varianc estim huber white appli adjust potenti confound factor total infant met inclus criteria receiv smoflipid smoflipid associ lower growth veloc birth week correct gestat age compar intralipid weight z score adjust mean differ amd ci subgroup analysi indic main male infant smoflipid le group lower weight z score compar intralipid group p lt differ observ femal p smoflipid associ lower rate bronchopulmonari dysplasia bpd arr ci higher rate late onset sepsi compar intralipid arr ci smoflipid associ lower growth veloc bpd higher rate late onset sepsi doubl edg sword | D001997;D007235;D018805 | T047;T046 |
36,235,603 | food hub mean promot food secur post secondari institut scope review estim post secondari student experi food insecur student food insecur like poor health lower academ perform relat food secur peer food hub physic digit space provid access food initi wraparound program employ placement incom support increas interest mean respond food insecur conduct scope review identifi best practic effect approach food hub promot food secur post secondari institut north america medlin embas cab direct web scienc databas search total articl identifi screen two review four articl includ encompass mix intervent campus pantri garden food rescu program food literaci base curriculum toolkit support implement intervent campus heterogen studi preclud identif best practic posit impact intervent note metric self efficaci greater awar food insecur gap evid effect approach promot campus food secur critic barrier develop implement intervent address futur studi | D063105;D005523 | T057;T081;T064 |
36,235,602 | barrier enhanc function solubl yam dioscorea opposita thunb polysaccharid rat intestin epitheli cell affect coval se conjug non starch yam polysaccharid yp bioactiv substanc edibl yam se essenti nutrient human bodi whether coval conjug se yp might caus bioactiv chang result selenyl yp intestin still insuffici studi includ critic intestin barrier function studi two selenyl yp product name ypse ypse ii correspond se content mgkg obtain reaction yp na seo presenc hno assess bioactiv cell model ie rat intestin epitheli iec cell result show yp ypse ypse ii gml dosag could promot cell growth treatment time h three sampl also could improv barrier integr via increas cell monolay resist anti bacteri activ e coli reduc paracellular permeabl bacteri transloc addit three sampl enhanc f actin distribut promot express three tight junction protein name zonula occluden occludin claudin meanwhil express level rock rhoa two critic protein rockrhoa singl pathway regul sampl collect ypse especi ypse ii potent yp enhanc assess bioactiv thus conclud chemic selenyl yp brought enhanc activ cell promot barrier integr higher selenyl extent selenyl yp induc much activ enhanc collect result highlight import role non metal nutrient se modifi polysaccharid | D027742 | T168;T002 |
36,235,601 | geograph variat dietari pattern associ overweightobes hypertens china find china nutrit health surveil region dietet cultur indic china dietari pattern geograph vari across china unknown studi systemat investig associ dietari pattern overweightobes hypertens potenti mechan nation sampl studi includ adult age year older china nutrit health surveil complet outcom data reliabl intak calori cook oil unchang diet habit without diagnos cancer cardiovascular diseas outcom overweightobes hypertens use gaussian finit mixtur model four dietari pattern identifi common rice base dietari pattern crb prudent diversifi dietari pattern pd northern wheat base dietari pattern nwb southern rice base dietari pattern srb geograph variat dietari pattern depict age sex standard proport pattern across provinc china assess associ dietari pattern outcom calcul proport mediat pm overweightobes associ dietari pattern hypertens evid geograph dispar dietari pattern across provinc observ crb refer group covari adjust nwb higher odd overweightobes odd ratio confid interv ci p lt hypertens ci p lt pm srb pd lower odd overweightobes or cis p lt hypertens or cis p srb p lt pd pms highest risk overweightobes nwb present relat higher carbohydr intak energi relat low fat intak energi differ trend associ protein intak overweightobes among dietari pattern relat differ anim food sourc conclus geograph distribut dispar dietari pattern illustr exist extern environ factor underscor need geograph target dietari action optim overal dietari pattern key manag overweightobes hypertens china emphasi reduc low qualiti carbohydr intak particular peopl typic northern diet select anim food particular peopl typic southern diet | D006973;D050177 | T047;T033 |
36,235,600 | vitamin supplement allerg diseas childhood systemat review meta analysi perform systemat review meta analysi investig effect vitamin vitd supplement children allerg diseas medlin embas web scienc cochran librari three chines databas search august random control trial rcts compar vitd supplement versus placebo children allerg diseas includ thirti two rcts particip includ vitd supplement reduc risk asthma exacerb children compar placebo overal risk ratio rr confid interv ci p reduc risk asthma exacerb children baselin serum oh lt ngml compar placebo rr ci p vitd supplement signific reduc score atop dermat eczema area sever index score children atop dermat compar placebo standard mean differ ci p vitd supplement also reduc symptom medic score children allerg rhiniti compar placebo mean standard deviat vs p conclus vitd supplement reduc asthma exacerb risk children overal may reduc asthma exacerb risk children serum oh concentr lt ngml vitd supplement reduc sever atop dermat symptom allerg rhiniti children | D001249;D003876;D065631 | T047 |
36,235,599 | quantiti sourc protein complementari feed infant growth evid popul face doubl burden malnutrit high protein intak infanc may increas obes risk low qualiti quantiti protein contribut undernutrit studi aim investig impact amount sourc protein infant growth complementari feed cf countri overnutrit co exist call doubl burden malnutrit | D061385;D044342 | T121;T047 |
36,235,598 | public health implic wast stunt relationship children five year high vulner undernutrit guatemala redac studi background guatemala latin american countri highest preval childhood stunt short height bias diagnosi wast use weight height indic aim studi evalu diagnost concord anthropometr indic wast relationship wast stunt children high vulner communiti guatemala method sampl consist anthropometr record children five year age girl averag age month includ weight height mid upper arm circumfer muac collect march august proport stunt underweight wast assess three differ indic well concurr composit index anthropometr failur calcul result stunt affect sampl show anthropometr failur wast vari indic weight height muac muac age concord muac weight height low kappa sensit muac identifi wast children stunt group vs opposit occur non stunt group vs conclus presenc stunt affect diagnosi wast indic includ diagnost criteria screen campaign treatment moder acut wast vulner popul affect multipl form undernutrit | D044342;D011634 | T047;T091 |
36,235,597 | high dietari folic acid intak associ genom instabl peripher lymphocyt healthi adult mandatori fortif food synthet folic acid fa institut reduc incid neural tube defect adequ folat status correl numer health benefit howev elev consumpt fa controversi associ deleteri effect health previous report excess fa mimick folat deplet lymphoblastoid cell line explor impact fa intak fortifi food conduct observ human studi healthi particip age take supplement food intak anthropomorph measur blood sampl collect analyz result show individu belong highest tertil folic acid intak well one highest folic acid total folat intak ratio far display signific greater incid lymphocyt genom damag decreas global dna methyl observ highest tertil far compar lowest p downward trend overal gene express select dna repair one carbon cycl gene mgmt mlh ung mthfr mtr note increas folat status fa intak result provid support evid high consumpt fa fortifi food precipit genom instabl peripher lymphocyt vivo | D005492;D009436 | T047;T019;T121;T109;T127 |
36,235,596 | food frequenc questionnair personalis use multi target regress fondazion bruno kessler develop mobil app prototyp empow citizen improv health condit differ lifestyl intervent incorpor mobil applic lifestyl promot provinc trento context trentino salut compet center envis intervent base promot behaviour chang various domain physic activ mental health nutrit particular nutrit compon self monitor modul collect dietari habit analys recommend healthier eat behaviour dietari assess complet use food frequenc questionnair mediterranean diet present user grid imag questionnair return feedback aspect nutrit although questionnair use applic consist question still could bit overwhelm bit crowd shown screen paper tri find machin learn base solut reduc number question questionnair propos method use user previous answer addit inform find goal need attent compar method case subset question random select case subset chosen use featur select also explor larg subset obtain good predict experi conduct multi target regress problem mean sever goal predict simultan propos method adjust well user question slightest error predict goal | D005247;D008019 | T055;T047;T054;T040 |
36,235,595 | comparison australian dietari guidelin nova classif system classifi food predict energi intak bodi mass index nova classif distinguish food level process evid suggest high intak ultra process food upf nova categori lead obes australian dietari guidelin contrast discourag excess consumpt discretionari food dfs defin accord composit compar classif australian food two system ii evalu perform predict energi intak bodi mass index bmi free live australian iii relat outcom protein leverag hypothesi obes secondari analysi australian nation nutrit physic activ survey conduct non protein energi intak increas mj p lt lowest highest tertil df intak signific higher upf mj p lt demonstr australia df classif better distinguish food associ high energi intak nova system bmi posit associ dfs p upf p consumpt differ strength associ classif macronutri energi intak conform close predict protein leverag account similar differ perform two system analysi australian food | D004032;D002149 | T168;T081 |
36,235,594 | associ selenium level gestat diabet mellitus updat systemat review meta analysi sever studi investig associ selenium level gestat diabet mellitus gdm howev result conclus systemat review meta analysi aim updat draw conclus regard evid publish studi investig selenium level relat gdm pubm googl scholar cochran librari sciencedirect search studi relat selenium gdm publish incept databas juli meta analysi conduct measur standard mean differ smd selenium level women gdm pregnant without gdm control group stratifi meta analysi meta regress analysi report bias appli meta packag open access softwar r use analyz data total studi includ pregnant women gdm control met studi inclus criteria selenium level signific lower women gdm compar control group smd confid interv ci p due signific heterogen cochran q p random effect model follow stratifi meta analysi show selenium level lower case compar normal control third trimest smd p trend observ studi publish year smd p publish smd p none investig covari meta regress analysi studi geograph locat trimest selenium quantif world bank econom classif method selenium determin studi design studi qualiti score public year studi sampl size signific associ selenium smd current evid indic selenium level lower among women gdm comparison without gdm howev correct report bias result longer signific studi prospect design need confirm evid explain function selenium gdm throughout pregnanc | D016640;D012643 | T121;T047;T123;T196 |
36,235,593 | astaxanthin inhibit oxid stress induc ku protein degrad apoptosi gastric epitheli cell oxid stress induc dna damag repair dna repair protein ku excess reactiv oxygen speci ros stimul activ caspas degrad ku cell decreas ku protein level undergo apoptosi astaxanthin exert antioxid activ induc express catalas antioxid enzym gastric epitheli cell therefor astaxanthin may inhibit oxid stress induc dna damag prevent ku protein degrad therebi suppress apoptosi ku protein degrad via ubiquitin neddyl add ubiquitin like protein substrat protein aim determin whether oxid stress decreas ku express ubiquitin proteasom pathway induc apoptosi whether astaxanthin inhibit oxid stress induc chang gastric epitheli ag cell induc oxid stress caus treatment glucos g glucos oxidas go cell result ggo treatment increas ros level decreas nuclear ku protein level ku dna bind activ induc ubiquitin ku ggo increas dna damag marker level hax dna fragment apoptosi marker annexin v posit cell cell death astaxanthin inhibit ggo induc alter includ ku degrad ag cell mln neddyl inhibitor mg proteasom inhibitor suppress ggo mediat dna fragment decreas cell viabil result indic ggo induc oxid stress caus ku protein loss ubiquitin proteasom pathway result dna fragment apoptot cell death astaxanthin inhibit oxid stress mediat apoptosi via reduct ros level inhibit ku protein degrad conclus dietari astaxanthin supplement astaxanthin rich food consumpt may effect prevent delay oxid stress mediat cell damag suppress ku protein loss apoptosi gastric epitheli cell | D000975;D046988 | T116;T121;T126;T123;T044;T039 |
36,235,592 | ginsenosid restor lipid redox homeostasi mice intrahepat cholestasi sirtampk pathway intrahepat cholestasi ic occur liver system circul accumul bile compon lead lipid metabol disord oxid damag ginsenosid gs pharmacolog activ plant product deriv ginseng possess lipid regul antioxid activ purpos studi evalu possibl protect effect ginsenosid gs lipid homeostasi disord oxid stress mice alpha naphthylisothiocyan anit induc ic investig under mechan comprehens strategi via incorpor pharmacodynam molecular biolog technolog adopt investig therapeut mechan gs anit induc mice liver injuri effect gs cholestasi studi mice expos anit induc cholestasi human hepg cell line use vitro investig molecular mechan gs might improv ic gene silenc experi liver specif sirtuin sirt knockout sirt lko mice use elucid mechan general physic indic assess biolog sampl collect serum biochem index lipid metabol oxid stress relat indic quantit pcr h e stain use molecular patholog analysi alter express level key pathway protein sirt p ampk nrf valid western blot modul ampk protein express gs decreas hepat lipogenesi increas fatti acid oxid lipoprotein lipolysi therebi improv lipid homeostasi ic mice furthermor gs reduc anit trigger oxid damag enhanc nrf downstream target level notabl protect result gs elimin sirt shrna vitro sirt lko mice vivo gs restor balanc lipid metabol redox liver anit induc ic model via sirtampk signal pathway thus exert protect effect anit induc cholestat liver injuri | D002779;D002780;D036145 | T121;T047;T109 |
36,235,591 | dietari vitamin b complex orchestr human nutrit throughout life sex differ import b complex vitamin start earli human life cycl continu across differ stage time numer report emphas critic role adequ b complex intak studi examin issu concern specif vitamin b life stage major report effect either excess defici deep insight orchestr eight differ b vitamin requir review across human life cycl begin fertil pregnanc reach adulthood senil emphas interact among under action mechan effect sex also review vitamin life stage highlight differ daili requir andor outcom thiamin riboflavin niacin pyridoxin folic acid crucial matern fetal health infanc childhood b vitamin integr physic psycholog develop pivot impact one overal health adolesc adulthood higher intak b vitamin elder also associ prevent age problem especi relat inflamm supplement care monitor avoid toxic hypervitaminosi research invest studi vitamin individu concern nutrit dispar life stage extens attent paid cultur differ lifestyl | D009525;D014803 | T121;T109;T127 |
36,235,590 | novel insight physiopatholog manag obes relat kidney diseas obes recogn independ risk factor develop kidney diseas led design obes relat glomerulopathi org common renal featur observ condit includ glomerular hypertrophi glomerulosclerosi haemodynam chang glomerular filtrat barrier defect addit although less studi obes relat kidney diseas also involv alter renal tubul includ tubul hypertrophi lipid deposit tubulointerstiti fibrosi although complet understood harm effect obes kidney may mediat differ mechan alter adipos tissu probabl play import role increas viscer adipos tissu classic associ develop kidney damag howev recent studi point adipos tissu surround kidney specif fat within renal sinus potenti involv develop org addit new strategi treatment patient obes relat kidney diseas focus manag obes regard non invas option glucagon like peptid glp receptor agonist sodium glucos cotransport sglt inhibitor consid applic clinic patient diabet kidney diseas novel pharmacolog strategi patient org addit bariatr surgeri stand one effect option weight loss also improv kidney outcom obes patient chronic kidney diseas | D003928;D009765 | T047 |
36,235,589 | pregnant dutch women inadequ iodin status selenium intak iodin selenium essenti thyroid hormon synthesi iodin selenium interact pregnanc increas matern iodin requir previous report inadequ iodin status pregnant dutch women sinc littl known selenium intak investig iodin status selenium intak relat iodin selenium supplement use pregnanc iodin status establish appar healthi pregnant women h iodin excret h uie suffici median g iodin concentr h uic gl iodinecreatinin ratio h uicr gg selenium intak calcul h selenium excret iodin status pregnanc prove insuffici median h uie g h uic gl h uicr gg women take g iodineday suffici median h uie g selenium intak estim averag requir ear gday recommend dietari allow rda gday adequ intak ai gday combin inadequ iodin status selenium intak lt rda found women want becom pregnant consist eta recommend advis use g iodin contain supplement concomit selenium supplement ad advic least netherland | D007455;D012643 | T121;T123;T196 |
36,235,588 | impact prenat vitamin supplement program vitamin defici ricket earli childhood cari alaska nativ popul earli childhood ricket increas alaska nativ children decreas vitamin rich subsist diet childbear age women evalu impact routin prenat vitamin supplement initi alaska yukon kuskokwim delta fall | D000072957;D003731;D012279;D014808 | T098;T047;T033 |
36,235,587 | melatonin next vitamin review emerg scienc clinic use safeti dietari supplement melatonin becom popular dietari supplement known chronobiot establish healthi sleep research last decad cancer alzheim diseas multipl sclerosi fertil pcos mani condit combin covid pandem led greater awar melatonin abil act potent antioxid immun activ agent mitochondri regul distinct similar melatonin vitamin depth breadth impact health act hormon affect multipl system immun modul anti inflammatori function found skin respons sunlight dark fact may similar widespread concern vitamin defici sunlight defici reduc melatonin secret result dark defici overexposur artifici blue light trend toward greater use melatonin supplement result concern safeti especi higher dose long term use applic certain popul eg children review aim evalu recent data melatonin mechan clinic use beyond sleep safeti concern thorough summari therapeut consider concern dietari supplement includ differ format avail anim synthet phytomelatonin dose time contraind nutrient combin | D000086382;D008550 | T047;T121;T109;T067;T125 |
36,235,586 | predict valu advanc lipoprotein profil glycat protein diabet retinopathi studi aim assess whether advanc characterist serum lipoprotein subclass could better predict risk develop diabet retinopathi dr sever compar establish risk factor subject type td type td diabet observ cross section substudi analyz dr relat data td td subject advanc lipoprotein glycoprotein profil determin nuclear magnet reson nmr spectroscopi liposcal test nmr analysi lipoprotein reveal td subject dr show standard non hdl particl despit higher idl lipid concentr notabl idl lipid elev td subject worsen dr vldl ldl smaller wherea hdl triglycerid increas dr compar non dr hand td subject dr show alter characterist ldl fraction main reveal signific decreas smaller ldl reduct ldl c moreov glycoprotein profil reveal signific chang among dr group regardless type diabet howev lipoprotein characterist glycoprotein unveil nmr analysi improv predict valu convent lipid tradit well establish biomark dr cohort | D003922;D003924;D003930 | T047 |
36,235,585 | greater ultra process food intak pregnanc postpartum associ multipl aspect lower diet qualiti low diet qualiti pregnanc postpartum associ numer advers matern infant health outcom studi examin relat ultra process food intak diet qualiti pregnanc postpartum use data h recal ultra process food intak operation percent energi intak nova classifi ultra process food diet qualiti measur use healthi eat index hei total compon score pearson correl examin associ ultra process food intak hei total compon score food group intak compar across four level ultra process food intak averag ultra process food compris mean sd energi intak pregnanc postpartum ultra process food intak invers correl hei total compon score compar particip highest ultra process food intak energi lowest ultra process food intak lt energi point higher hei total score consum time fruit veget seafood plant protein time total protein addit consum much refin grain much ad sugar greater ultra process food intak associ lower diet qualiti across hei compon reduc ultra process food intak may broad improv adher dietari guidelin pregnant postpartum popul | D004032;D002149;D049590 | T101;T168;T081;T079 |
36,235,584 | isinglass polysaccharid regul intestin barrier function allevi obes high fat diet mice ho nrf pathway intestin microbiom environ plant polysaccharid intervent shown signific potenti combat obes howev studi anim polysaccharid inde rare aim studi investig potenti function cip il obes intestin microflora dysbiosi possibl protect intestin barrier mice fed high fat diet hfd result reveal week hfdl high fat diet mgkg cip group show signific weight loss fat accumul relat hfdh high fat diet mgkg cip group furthermor cip intervent modul lipid metabol mrna level inflammatori mediat liver overal cip clear improv intestin barrier hfd fed mice addit observ cip intervent improv intestin microbiota communiti rich divers hfd fed mice cip intervent mice group show relat low firmicut bacteroidet ratio compar hfd group studi conclud cip could use function food prevent adipocyt accumul reduc system inflamm protect intestin barrier | D059305;D000069196 | T007;T061;T001 |
36,235,583 | arenga pinnata resist starch modul gut microbiota amelior intestin inflamm age mice studi aim compar regulatori effect arenga pinnata retrograd starch apr arenga pinnata starch ap whole arenga pinnata flour apf gut microbiota improv intestin inflamm age mice apf ap apr alter gut microbiota composit exhibit differ prebiot effect bifidobacterium show greatest increas fece age mice fed apf abund genus lachnospiracea nka highest ap group apr supplement led greatest increas abund lactobacillus roseburia faecalibacterium prausnitzii apr induc signific short chain fatti acid scfas product apf ap apf ap apr treatment improv intestin inflamm age mice order amelior effect apr gt ap gt apf apr signific decreas relat mrna express pro inflammatori cytokin il il tnf increas anti inflammatori cytokin il addit apf ap apr signific downregul relat mrna express senesc associ gene p upregul express anti age gene sirt result provid potenti use inform benefici effect arenga pinnata product human health | D028023;D000069196 | T007;T001;T002 |
36,235,582 | efficaci mechan pueraria lobata pueraria thomsonii polysaccharid treatment type diabet diabet call wast thirst disord chines tradit medicin deplet vital substanc bodi independ intak food water inabl reintroduc fluid drink pueraria lobata willd ohwi gg pueraria thomsonii benth fg tradit chines herbal medicin use treatment wast thirst reduc blood glucos level flavonoid main pharmacodynam compon gg fg also studi compon present polysaccharid also activ compon gg fg howev less studi therefor studi aim investig effect pueraria polysaccharid gg fg polysaccharid type diabet td well relat mechan action term intestin flora metabolom cblksj dbdb mous model well establish model obes induc td use studi metabolom analysi show pueraria polysaccharid improv metabol profil diabet mice signific regul metabolit metabol pathway gg fg polysaccharid regul insulin resist mice regul ppar signal pathway treat td addit pueraria polysaccharid regul structur gut microbiota improv diabet relat metabol pathway therefor studi discov antidiabet effect potenti mechan pueraria polysaccharid multipl pathway involv gut microbiota metabolit provid theoret basi studi effect treatment td | D003921;D003924;D028321;D029908 | T121;T050;T047;T002 |
36,235,581 | iron deplet system muscl compart defin specif phenotyp sever copd femal male patient implic exercis toler hypothes iron content regulatori factor may involv exercis toler differenti express system muscl compart iron defici sever chronic obstruct pulmonari diseas copd patient vastus laterali blood sever copd patient withwithout iron deplet iron content regul exercis capac muscl function evalu sever copd patient non iron defici nid iron defici id patientsgroup id compar nid patient exercis capac muscl iron ferritin content serum transferrin satur hepcidin hemojuvelin decreas serum transferrin solubl transferrin receptor muscl irp irp increas among copd signific posit correl detect fev serum transferrin satur id patient signific posit correl detect serum ferritin hepcidin muscl iron content exercis toler muscl irp serum ferritin hepcidin level id sever copd patient iron content regul differenti express potenti crosstalk system muscl compart observ id patient lung function exercis capac associ sever marker iron metabol regul iron status includ overal assess copd patient given implic exercis perform | D018798;D000090463;D029424 | T047 |
36,235,580 | high folat perturb one carbon metabol gestat diabet mellitus folat dietari micronutri essenti one carbon metabol world health organis recommend folic acid fa supplement pre concept earli pregnanc reduc risk fetal neural tube defect ntds subsequ mani countri mandatori fa fortif polici well recommend periconcept fa supplement mandatori fortif initi larg success reduc incid ntds howev human limit capac incorpor fa one carbon metabol pathway result increas ubiquit presenc circul unmetabolis folic acid ufa excess fa intak emerg risk factor gestat diabet mellitus gdm sever one carbon metabol compon vitamin b homocystein cholin deriv betain also close entwin gdm risk suggest role one carbon metabol gdm pathogenesi grow evid vitro anim studi suggest role excess fa dysregul one carbon metabol specif high level fa reduc methylenetetrahydrofol reductas mthfr activ dysregul balanc thymidyl synthas ts methionin synthas mtr activ elev homocystein high homocystein associ increas oxid stress trophoblast apoptosi reduc human chorion gonadotrophin hcg secret pancreat cell function relationship high fa perturb one carbon metabol gdm pathogenesi yet fulli understood summaris current state knowledg given rise rate gdm estim global widespread fa food fortif research urgent need elucid mechan underpin gdm pathogenesi | D016640;D009436 | T047;T019 |
36,235,579 | effect oliv pomac oil cardiovascular health associ patholog oliv pomac oil opo nutrit relev fat due high oleic acid content c presenc wide rang minor bioactiv compon although numer vitro preclin studi develop studi characterist compon health effect prolong opo consumpt unknown | D002319;D000069463 | T022;T109;T168 |
36,235,578 | doctor drink alcohol free beer low alcohol alcohol free drink peopl heavi drink alcohol use disord systemat review literatur low alcohol drink nolo propos potenti way forward reduct alcohol burden diseas far scarc synthes evid effect product peopl alcohol use disord aud heavi high risk drink pattern aim present studi systemat review evid use nolo drink popul total record screen studi includ review crave desir drink found increas consumpt nolo drink patient aud increas crave correl sever alcohol depend addit popul alcohol relat cue might trigger physiolog respons similar experienc use alcohol furthermor mention studi consumpt shown increas abv verbal descriptor indic lower alcohol last accord epidemiolog data heavi drinker tend use nolo drink top usual alcohol consumpt rather part regular drink pattern studi conduct peopl aud peopl high risk drink pattern provid new insight guid clinician patient stakehold make evid base inform decis | D000437 | T048 |
36,235,577 | withania somnifera extract promot resili age relat stress induc behavior phenotyp drosophila melanogast possibl role compound besid withanolid withania somnifera ws extract use tradit medicin millennia promot healthi age wellb ws also wide use western countri nutrit supplement extend healthspan increas resili age relat chang includ sleep deficit depress although human trial support benefici effect ws studi design vari wide plant materi intrins complex extract vari wide origin plant materi extract method commerci supplement contain various ingredi characterist studi popul also vari perform maxim control experi use plant extract analyz composit stabil test extract inbr drosophila line minim effect genet background control environ found water extract ws wsaq potent improv physic fit ethanol extract wse improv sleep age fli extract provid resili stress induc behavior chang wse contain higher level withanolid propos activ ingredi wsaq therefor withanolid may mediat sleep improv wherea far unknown ingredi enrich wsaq like mediat effect fit stress relat behavior | D032341;D054358 | T109;T002 |
36,235,576 | alter intestin brush border membran function bacteri popul follow intra amniot administr gallus gallus catechin deriv catechin flavonoid natur present numer dietari product fruit eg appl berri grape seed kiwi green tea red wine etc previous shown antioxid benefici gut microbiom enhanc health benefit bioavail stabil catechin synthes character catechin pentaacet catechin pentabutano two new ester deriv catechin catechin deriv assess vivo via intra amniot administr gallus gallus follow treatment group non inject control deioniz h control tween mgml dose inulin mgml dose catechin mgml dose catechin pentaacet mgml dose catechin pentabutano mgml dose effect physiolog marker associ brush border membran morpholog intestin bacteri popul duoden gene express key protein investig compar control result demonstr signific p lt decreas clostridium genera e coli speci densiti catechin synthet deriv exposur furthermor catechin deriv decreas iron zinc transport ferroportin znt respect gene express duodenum compar control conclus catechin synthet deriv potenti improv intestin morpholog function posit modul microbiom | D002392;D002645 | T121;T109;T012 |
36,235,575 | sixteen week vitamin supplement increas peripher cell overweight black individu post hoc analysi random doubl blind placebo control trial vitamin consid modul cell function implic treatment inflammatori condit howev limit knowledg effect vitamin influenc circul cell profil human particular overweight black individu like vitamin insuffici serum oh concentr ngml thus studi test hypothesi vitamin supplement modul cell composit dose depend manner | D002762;D014808 | T121;T047;T109;T127 |
36,235,574 | zinc supplement partial decreas harm effect cafeteria diet rat prevent intestin dysbiosi zinc zn play import role metabol homeostasi may modul neurolog impair relat obes present studi aim evalu effect zn supplement intestin microbiota fatti acid profil neurofunct paramet obes male wistar rat rat fed cafeteria diet caf compos ultra process high calor palat food week induc obes week zn supplement start mgkgday end experi evalu colon morpholog composit gut microbiota intestin fatti acid integr intestin barrier blood brain barrier bbb neuroplast marker cerebr cortex hippocampus obes rat show dysbiosi morpholog chang short chain fatti acid scfa reduct increas satur fatti acid colon bbb may also compromis caf fed anim claudin express reduc cerebr cortex addit synaptophysin decreas hippocampus may affect synapt function find show zn could protect obes anim intestin dysbiosi howev increas acet level observ suggest partial benefici effect zn thus zn supplement may suffici protect obes relat dysfunct | D059305;D064806 | T061;T047;T046 |
36,235,573 | wogonin compound scutellaria baicalensi activ atf fgf signal mous hepatocyt aml cell fibroblast growth factor fgf main synthes secret liver play crucial role system glucos lipid metabol amelior metabol diseas studi screen wakanyaku librari deriv medicin herb identifi compound activ fgf express mous hepatocyt aml cell identifi scutellaria baicalensi root extract one compon wogonin activ fgf express wogonin also enhanc express activ transcript factor atf mechan er stress knockdown atf sirna suppress wogonin induc fgf express highlight essenti role wogonin mode action thus result indic wogonin would strong candid therapeut improv metabol diseas enhanc hepat fgf product | D044950;D031364 | T121;T109;T002 |
36,235,572 | burden nutrit defici china find global burden diseas studi age standard incid rate nutrit defici china remain stabl howev age standard disabl adjust life year dali rate nutrit defici decreas data extract gbd dataset estim annual percentag chang eapc calcul assess incid rate dali trend nutrit defici measur stratifi subtyp region age group age standard dali rate dietari iron defici protein energi malnutrit reach highest level main popul group protein energi malnutrit dietari iron defici adult age children age five latter group also greater burden vitamin defici zhejiang beij guangdong report highest age standard incid rate nutrit defici main pertain protein energi malnutrit vitamin defici tibet xinjiang hainan highest age standard dali rate nutrit defici main pertain dietari iron defici protein energi malnutrit | D011502;D014802 | T047;T046 |
36,235,571 | oral erythritol reduc energi intak subsequ ad libitum test meal random control crossov trial healthi human impact oral erythritol subsequ energi intak unknown aim assess effect oral erythritol compar sucros sucralos tap water energi intak subsequ ad libitum test meal examin releas cholecystokinin cck respons substanc random crossov trial healthi volunt receiv g erythritol g sucros g sucralos dissolv tap water tap water oral preload four differ session fifteen minut later test meal serv energi intak assess set time point blood sampl collect quantifi cck concentr energi intak ad libitum test meal signific lower erythritol compar sucros sucralos tap water p lt start ad libitum test meal erythritol led signific increas cck compar sucros sucralos tap water p lt oral erythritol given alon induc releas cck start ad libitum test meal reduc subsequ energi intak compar sucros sucralos tap water properti make erythritol use sugar altern | D002149;D004896 | T121;T109;T123;T081 |
36,235,570 | effect branch chain amino acid skelet muscl glycem control neuropsycholog perform elder person type diabet mellitus exploratori random control trial although branch chain amino acid bcaa known stimul myofibrillar protein synthesi affect insulin signal kynurenin metabol latter metabolit tryptophan associ depress dementia effect bcaa supplement type diabet td clear therefor week prospect random open blind endpoint trial conduct evalu effect supplement g bcaa g soy protein skelet muscl glycem control well advers event elder individu td thirti six particip random assign bcaa group n soy protein group n skelet muscl mass hbac primari endpoint chang time differ group howev knee extens muscl strength signific increas soy protein group show tendenc increas bcaa group homeostasi model assess insulin resist signific chang trial depress symptom signific improv bcaa group differ group signific result suggest bcaa supplement may affect skelet muscl mass glycem control may improv depress symptom elder individu td | D000597;D003924 | T047;T123;T116 |
36,235,569 | postprandi glycem insulinem respons brewer spent grain extract base food supplement subject slight impair glucos toler monocentr random cross doubl blind placebo control clinic trial dietari fiber exert benefici effect human health reduc risk factor metabol relat diseas hyperglycemia insulin resist hypercholesterolemia aim studi demonstr efficaci food supplement base brewer spent grain bsg extract reduct postprandi glycemia insulinemia normoglycem subject bsg chemic character reveal presenc resist starch g g arabinoxylan g g glucan g g solubl fiber g g bioaccess ferul acid mg g clinic studi normoglycem subject random two group n cross clinic design receiv either bsg extract base food supplement placebo postprandi blood glucos valu signific lower correspond valu placebo group min baselin first min two glycem curv overlap substanti improv clinic outcom corrobor signific reduct postprandi insulinemia none subject report advers effect studi show test bsg extract base food supplement improv glucos metabol insulinem respons normoglycem subject mild insulin resist | D018149;D007333;D047071 | T121;T047;T046;T109 |
36,235,568 | joint associ food group caus caus specif mortal mr os ms os studi prospect cohort despit continu growth dietari pattern research relat import dietari compon overal pattern joint effect mortal risk examin adequ explor individu joint associ multipl food group caus caus specif mortal cardiovascular diseas cvd cancer analyz data cohort hong kong chines older adult mr osteoporosi os ms os studi cox proport hazard model use examin associ food group mortal risk individu joint contribut food group mortal risk quantifi machin learn approach ie quantil g comput compar highest lowest quartil intak dark green leafi veget hazard ratio hr confid interv ci p trend fruit hr ci p trend legum hr ci p trend mushroom fungi hr ci p trend soy soy product hr ci p trend whole grain hr ci p trend invers associ caus mortal legum intak associ lower risk cvd mortal fruit nut soy soy product associ lower risk cancer mortal quantil g comput whole grain legum fruit mushroom fungi soy soy product higher relat weight mortal risk joint effect food group invers associ mortal risk due caus hr ci cvd hr ci cancer hr ci sex stratifi analysi associ food group whole grain legum fruit mushroom fungi soy soy product mortal risk remain signific among men conclus whole grain legum fruit mushroom fungi soy soy product main contributor reduct mortal risk joint effect stronger individu food group moreov sex specif associ sweet dessert cancer mortal may worth investig | D002318;D007887;D009369;D010024 | T191;T047;T002 |
36,235,567 | anti inflammatori diet fertil evid review infertil global health concern affect million coupl million individu worldwid infertil creat signific econom social burden coupl wish conceiv associ suboptim lifestyl factor includ poor diet physic inact modifi preconcept nutrit better adher food base dietari guidelin fbdgs non invas potenti effect mean improv fertil outcom sever dietari pattern associ fertil outcom mechanist link diet infertil remain unclear key mechan outlin literatur relat advers effect inflamm fertil potenti contribut irregular menstrual cyclic implant failur negat reproduct sequela therefor dietari intervent act reduc inflamm may improv fertil outcom review consist show adher anti inflammatori diet mediterranean diet specif increas intak monounsatur n polyunsatur fatti acid flavonoid reduc intak red process meat improv fertil assist reproduct technolog art success sperm qualiti men therefor integr anti inflammatori dietari pattern low risk adjunct fertil treatment may improv fertil partial fulli reduc need prolong intens pharmacolog surgic intervent | D038441;D007246 | T061;T046;T033 |
36,235,566 | nutrit composit estim iron zinc bioavail meat substitut avail swedish market transit toward plant base diet advoc reduc climat footprint health implic diet compos meat substitut current unknown knowledg gap nutrit composit qualiti sampl avail meat substitut bought two conveni store citi gothenburg sweden includ studi meat substitut n analyz content dietari fiber fat iron zinc phytat salt total phenol protein well amino acid fatti acid composit bioavail iron zinc estim base phytat miner molar ratio found larg variat nutrit composit analyz meat substitut amino acid profil seem affect process method mycoprotein product rich zinc median content mg g low content phytat suggest mycoprotein good sourc zinc degrad fungal cell wall might howev pose potenti aggrav factor none product could regard good sourc iron due high content phytat mg g andor low content iron mg g phytat iron molar ratio product iron content gt mg g rang tempeh stood protein sourc larg potenti due low phytat content mg g iron content mg g close level nutrit claim produc product analyz studi appear use nutrit claim regard iron appear line european regul sinc iron form avail bodi meat substitut analyz studi contribut absorb iron relev manner individu follow main plant base diet meet iron need sourc salt satur fat high certain product product line nutrit recommend investig nutrit health effect protein extract extrus need conclud nutrit knowledg need implement product develop meat substitut | D010833;D015032 | T121;T109;T123;T127;T130;T196 |
36,235,565 | trace element interact inflammatori signal male sex implic reduc growth follow excess oral iron supplement pre weanl rat iron supplement frequent provid infant high incom countri despit low incid iron defici grow concern regard advers health develop outcom excess iron provis earli life excess iron may direct damag develop organ format reactiv oxygen speci alter system inflammatori signal andor dysregul trace miner metabol better character vivo effect excess iron develop util pre weanl rat pup model lewi rat litter cull eight pup four male four femal random assign daili supplement group receiv either vehicl control con wv sucros solut ferrous sulfat fs iron one follow dose mg ironkg bodi weight fs fs fs respect postnat day pd fs litter fs fs fail thrive compar con litter smaller brain pd among group fs liver iron level highest white blood cell count compar con circul mcp liver zinc increas fs pup wherea liver copper decreas growth defect due excess fs provis pre weanl rat may relat liver injuri inflamm alter trace miner metabol | D019190;D014131 | T121;T047;T123;T196 |
36,235,564 | limonium tetragonum promot run endur mice mitochondri biogenesi oxid fiber format purpos studi examin whether limonium tetragonum cultiv smart farm system led lamp could increas exercis capac mice cbl male mice oral administ vehicl limonium tetragonum water extract lte either mgkg subject moder intens treadmil exercis week run distanc mark increas lte group mgkg compar vehicl group accompani higher proport oxid fiber vs mitochondri dna content gene express relat mitochondri biogenesi signific increas lte supplement gastrocnemius muscl molecular level express pgc master regul fast slow fiber type transit increas downstream pkacreb signal pathway lte induct pkacreb signal pathway also observ cc cell effect suppress pka inhibitor h rp camp altogeth find indic lte treatment enhanc endur exercis capac via improv mitochondri biosynthesi increas format oxid slow twitch fiber futur studi warrant valid exercis enhanc effect lte human | D010805;D010936;D029606;D012420 | T002;T038;T121;T123;T056 |
36,235,563 | improv macro micronutri suppli favor growth metabolom profil standard parenter nutrit solut preterm infant preterm infant high risk suboptim nutrit first week life lead insuffici weight gain complic aris metabol imbal insuffici bone miner accret investig use novel set standard parenter nutrit pn muc prepar solut regard improv nutrit intak acceler termin parenter feed posit affect growth comparison individu prescrib compound pn solut studi effect muc prepar macro micronutri intak metabol growth preterm infant compar result histor refer group preterm infant match clinic characterist infant receiv muc prepar demonstr improv macro micronutri intak result balanc electrolyt level stabl metabolom profil subsequ improv energi suppli associ week earlier termin parenter feed simultan reach time higher weight gain day extrem immatur infant lt ga week well overal improv growth year age infant use new standard pn solut muc prepar improv nutrit suppli short long term growth reduc pn durat preterm infant consid superior therapeut strategi | D007235;D057947 | T121;T047;T168 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.