PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,235,232 | reveal angiopep lrp molecular interact optim deliveri glioblastoma gbm famili synthet peptid angiopep particular angiopep ang demonstr abil preclin clinic shuttl activ molecul across blood brain barrier bbb select toward brain tumor cell literatur also prove transport occur specif receptor mediat transcytosi peptid lrp receptor present bbb tumor cell membran howev contradictori result exploit promis mechan engin complex deliveri system nanoparticl obtain | D001932;D005909 | T191 |
36,235,231 | classif aggreg use multispectr two dimension angular light scatter simul airborn particul matter play import role climat chang health impact general irregular shape andor form agglomer particl may character light scatter signal two dimension angular scatter particl produc speckl pattern influenc morpholog shape materi composit follow revisit morpholog descriptor obtain comput generat light scatter pattern aggreg spheric particl descriptor use input multivari statist algorithm classifi via supervis machin learn algorithm classif result show improv accuraci previous effort demonstr util propos morpholog descriptor | D000465;D052638 | T170;T131;T167 |
36,235,230 | allerg inflamm effect propoli flavonoid incid allerg diseas complic increas worldwid today peopl increas use natur product term return natur natur product heal properti especi obtain plant bee use prevent treatment numer chronic diseas includ allergi andor inflamm propoli multi compon resin rich flavonoid collect transform honeybe bud plant wound construct adapt nest articl describ current view regard possibl mechan multipl benefit flavonoid combat allergi allergi relat complic benefit aris flavonoid anti allerg anti inflammatori antioxid wound heal activ effect microb immun system interact develop host respons differ allergen final articl present various aspect allergi pathobiolog possibl molecular approach treatment possibl mechan regard antiallerg action propoli microbiota digest respiratori tract skin diseas method select remov allergen molecul process bacteri biotransform also report | D018926;D001203;D001688;D006967;D011429 | T121;T046;T123;T004 |
36,235,229 | holmium complex phospholipid h nmr relax sensor temperatur viscos sensit ho phospholipid complex chang membran viscos liposom check increas viscos observ dppc dmpc near phase transit temperatur ho phospholipid complex could use sensor local membran viscos nmr mri technolog | D008081;D010743 | T109;T123 |
36,235,228 | influenc oxygen manag post ferment stage acetaldehyd color phenol viti vinifera l cv cabernet sauvignon wine oxygen exposur unavoid impact manag post ferment stage pfs dri red wine poor investig studi dedic variat acetaldehyd color phenol cabernet sauvignon dri red wine five discontinu oxid cycl four level control oxygen suppli carri simul probabl oxid pfs free disappear first second third oxid cycl wine high medium low level oxygen exposur sever subsequ oxygen exposur equal mg l per cycl littl effect mg l per cycl dramat facilit acetaldehyd accumul accompani enorm variat color pigment especi total oxygen consumpt mgl util cluster heatmap partial least squar regress demonstr feasibl character wine oxid degre use chemic paramet measur uv spectrophotometri oxygen exposur pfs emphat control chemic index determin uv spectrophotometr method use scientif effect descript wine oxid degre | D027843 | T168;T116;T002;T129 |
36,235,227 | consist factor viscos expon soybean protein isolatewheat glutencorn starch blend use capillari rheometri blend differ proport protein starch show differ rheolog behavior may relat fibrous structur format extrud textur plant protein consist factor k viscos expon n soybean protein isol spi wheat gluten wg corn starch cs blend investig capillari rheometri blend exhibit shear thin behavior c moistur cs content spic blend wg content spiwg blend show posit relat viscos expon n negat relat consist factor k howev correl cs content wgcs blend n k coeffici determin linear relationship k mass fraction spic spiwgc spiwg wgcs decreas spi like form non interact structur wheat gluten like form high interact structur turn materi globular morpholog soybean protein isol corn starch like form non interact structur | D013213;D014908 | T002;T121;T109;T123;T168 |
36,235,226 | deactivat bisubstr inhibitor protein kinas bival ligand includ bisubstr inhibitor conjug pharmacophor simultan target two bind site biomolecul structur offer attain mean develop compound whose abil bind biolog target could modul extern trigger present work two deactivat bisubstr inhibitor basophil protein kinas pks construct conjug pharmacophor via linker could cleav respons extern stimuli inhibitor arc incorpor photocleav nitrodibenzofuran compris amino acid residu structur linker pharmacophor deactivat inhibitor arc conjug via reduct cleavabl disulfid bond disassembl inhibitor monitor hplc ms affin inhibitori potenc inhibitor toward camp depend pk pkac establish equilibrium competit displac assay enzym activ assay respect deactivat inhibitor possess remark high picomolar affin toward pkac irradi arc nm uv radiat led reaction product possess fold reduc affin chemic reduct arc result decreas affin four order magnitud deactivat inhibitor pks valuabl tool tempor inhibit captur pharmacolog import enzym | D047428;D011494 | T121;T126;T116 |
36,235,225 | synthesi electrochem fluoresc properti first fluoresc member ferrocifen famili oxid deriv first fluoresc ferrociphenol deriv p synthes via mcmurri cross coupl follow copper catalyz azid alkyn cycloaddit fluoresc group coumarin cyclic voltammogram p exhibit either monoelectron oxid wave ascrib ferrocen fe ii fe iii convers three electron oxid process presenc base lead fe iii quinon methid adduct general sequenc consist previous describ non fluoresc ferrociphenol furthermor fluoresc properti p oxid intermedi appear strong depend redox state ferrocen group inde electrochem generat fe iii ferrocenium state mark increas fluoresc emiss intens contrast emiss fe ii ferrocen state partial quench photoinduc electron transfer pet fe ii donor coumarin acceptor concentr depend self quench owe switchabl fluoresc properti complex p could repres innov use tool studi biodistribut redox state ferrocifen cancer cell | D003300;D005290 | T121;T104;T123;T196 |
36,235,224 | photophys primari self referenc thermometr properti europium hydrogen bond triazin framework lanthanid hydrogen bond organ framework lnhof recent emerg novel versatil class multicompon luminesc materi promis potenti applic optic photon trival europium eu incorpor polymer hydrogen bond triazin framework phtf eu success obtain via facil low cost thermal pyrolysi rout phtf eu materi show porous frame structur princip compos isocyanur acid ammelid minor constitu intens red luminesc high colour puriti eu obtain excit broad absorpt band peak nm either room low temperatur triazin base host work excel optic antenna toward eu yield sensit effici sen intrins quantum yield eu emiss eu high temperatur depend emiss studi show phtf eu display relat high optic stabil elev temperatur comparison tradit inorgan phosphor retriev activ energi mev indic thermal quench mechan attribut intrins energi level structur metal triazin assembl possibl via thermal activ back transfer ligand triplet ct state final use innov approach base excit spectra demonstr phtf eu work univers primari self referenc thermomet base singl emit center excel relat sensit cryogen temperatur rang | D005063;D028581 | T196 |
36,235,223 | effect shift signal peptid cleavag site signal peptid variant synthesi secret sar cov spike protein covid pandem caus sar cov spike protein key structur protein mediat infect host sar cov studi aim evalu effect signal peptid secret releas sar cov spike protein therefor construct signal peptid delet mutant three signal peptid site direct mutant h region c region signal peptid lf si mutant chang signific compar wild type lf si demonstr effect signal peptid secret synthesi rbd protein find mutat signal peptid conduc secret rbd protein main due shift signal peptid cleavag site mutant si investig structur n termin signal peptid sar cov spike protein also consid possibl secretori pathway suggest develop drug target signal peptid sar cov spike protein may potenti treat covid futur | D000086382;D064370 | T116;T047;T123;T067 |
36,235,222 | andrographolid induc gm cell cycl arrest apoptosi human glioblastoma dbtrg mg cell line via erk c mycp signal pathway human glioblastoma multiform gbm one malign brain tumor high mortal rate worldwid convent gbm treatment challeng presenc blood brain barrier bbb drug resist post treatment advers effect henc develop bioactiv compound isol plant speci identifi molecular pathway facilit effect treatment becom crucial gbm base pharmacodynam studi andrographolid spark interest cancer research believ may allevi difficulti gbm therapi howev still requir studi andrographolid bicycl diterpen lacton deriv andrographi paniculata burmf wallich ex nee anticanc properti various cancer cell line present studi aim evalu andrographolid anticanc effect potenti molecular pathway use dbtrg mg cell line antiprolif activ andrographolid determin use wst assay scratch assay clonogen assay use evalu andrographolid effect cancer cell line examin cell migrat coloni format flowcytometri also use examin apoptosi cell cycl arrest induc andrographolid mrna protein express level involv erkc mycp signal pathway assess use qrt pcr western blot protein protein interact c myc p determin reciproc experi co immunoprecipit co ip use dbtrg mg total cell lysat andrographolid signific reduc viabil dbtrg mg cell line concentr time depend manner addit scratch clonogen assay confirm effect andrographolid reduc cell migrat coloni format dbtrg mg respect andrographolid also promot cell cycl arrest gm phase follow apoptosi dbtrg mg cell line induc erk c myc p express mrna level western blot result demonstr c myc overexpress also increas product anti apoptot protein p find reveal c myc p posit interact trigger apoptot signal pathway studi success discov involv erkc mycp suppress dbtrg mg cell line via cell cycl arrest follow apoptosi signal pathway follow andrographolid treatment | D004224;D005909 | T191;T109 |
36,235,221 | metabol profil gc ms vitro biolog potenti silico molecular dock studi verbena officinali verbena officinali l tradit import medicin herb rich sourc bioactiv phytoconstitu biolog benefit object studi assess metabol profil vitro biolog potenti v officinali bioactiv phytoconstitu evalu preliminari phytochem studi estim polyphenol content gas chromatographi mass spectrometri gc ms analysi fraction crude methanol n hexan ethyl acet n butanol v officinali biolog investig perform differ assay includ antioxid assay dpph abt cuprac frap enzym inhibit assay ureas glucosidas hemolyt activ ethyl acet extract maximum concentr total phenol total flavonoid content mg gaeg de mg qeg de respect signific antioxid potenti observ fraction four antioxid method maximum ureas inhibitori activ term ic valu shown ethyl acet fraction g ml comparison standard hydroxi urea gml n hexan extract show good glucosidas inhibitori efficaci gml compar extractfract minimum hemolyt activ found crude methanol fraction comparison posit standard triton x gc ms analysi extractfract v officinali includ crude methanol n hexan ethyl acet n butanol fraction result identif bioactiv compound respect qualiti index furthermor bioactiv compound identifi gc ms analyz use silico molecular dock studi determin bind affin ligand enzym ureas glucosidas conclus v officinali possess multipl therapeut potenti research need explor use treatment chronic diseas | D000975;D032412 | T002;T121;T123;T044;T039 |
36,235,220 | simul gastric intestin fluid electrolyt solut environ adsorpt appl polyphenol onto glucan interact dietari fiber gastrointestin tract might affect potenti bioactiv phenol compound studi interact appl phenol compound glucan dietari fiber studi studi adsorpt process simul gastric intestin fluid electrolyt solut phenol compound extract appl adsorb onto glucan h c gastric intestin fluid electrolyt solut determin use high perform liquid chromatographi phenol compound flavan ol flavonol phenol acid dihydrochalcon stabl gastric fluid ph intestin fluid ph flavan ol found chlorogen acid isomer polyphenol appl peel mg g flesh mg g adsorb onto glucan gastric intestin fluid respect adsorpt affect initi concentr polyphenol glucan environ either gastric intestin fluid electrolyt solut increas initi polyphenol amount quantiti adsorb polyphenol increas increas amount glucan decreas amount adsorb result help explain fate phenol compound gastrointestin tract | D027845;D047071 | T121;T109;T168;T002 |
36,235,219 | semisynthet abiet dehydroabiet acid deriv triptoquinon epim interfer lps trigger activ dendrit cell abiet acid aa dehydroabiet acid dha triptoquinon tqs bioactiv abietan type diterpenoid present mani edibl veget medicin herb health promot properti evid suggest benefici effect diterpen oper least part effect cell immun system dendrit cell dcs key type leukocyt involv initi regul immuneinflammatori respons natur synthet compound modul dc function could potenti anti inflammatoryimmunomodulatori agent herein report screen known semisynthet aa dha deriv tqs synthes previous us multi analyt dc base assay detect inhibit pro inflammatori cytokin product base magnitud inhibitori effect observ number cytokin inhibit varieti activ among compound observ rang inactiveweak potent inhibitor structur either alcohol methyl ester substitu ring along introduct aromat oxid ring c abietan skeleton found compound higher inhibitori properti two dha deriv two tqs exhibit signific inhibit pro inflammatori cytokin test investig result confirm abil inhibit dose depend lps stimul express co stimulatori molecul cd andor cd product pro inflammatori cytokin il il il tnf result demonstr dc matur process target semisynthet dha deriv tq epim indic potenti compound optimiz anti inflammatoryimmunomodulatori agent | D045784;D014409 | T109;T116;T129 |
36,235,218 | stimul lignan product schisandra rubriflora vitro cultur elicit studi investig effect elicit chitosan ch mgl yeast extract yee mgl ethephon eth ml methyl jasmon meja ml lignan accumul agit bioreactor plantform temporari immers system microshoot cultur femal f male schisandra rubriflora rehd et wil schisandracea line elicitor supplement th day cultur biomass collect h h day addit elicitor compound dibenzocyclooctadien aryltetralin dibenzylbutan tetrahydrofuran lignan neolignan determin qualit quantit biomass extract use uhplc msms method highest total content mg g dw lignan ch f day h yee f day day eth f h day meja f h h biomass extract cultur grown bioreactor highest total lignan content obtain meja elicit mg g dw maximum total lignan content biomass extract agit bioreactor cultur time higher respect extract non elicit cultur poor understand chemic composit lack studi field plant biotechnolog rubriflora emphas innov research | D048271;D017705;D032141 | T121;T109;T002 |
36,235,217 | antibacteri antifung silver nanoparticl tunabl size embed various cellulos base matric aim studi synthes silver nanoparticl agnp use cellulos deriv evalu antimicrobi potenti effect reduc stabil agent agnp cellulos deriv hydroxypropyl cellulos hpc methylcellulos mc ethylcellulos ec cellulos acet ca use abil reduc silver ion well size result agnp compar format stabil reduc agnp solut monitor use uv vis analysi size morpholog charg agnp evalu found use cellulos deriv agnp size rang nm differ stabil obtain paramet size potenti indic stabil agnp agnp ca agnp hpc consid stabl agnp ec agnp mc sinc show higher potenti valu addit agnp show antimicrobi activ refer strain clinic isol mic valu mm bactericid effect gram posit gram negat bacteria fungicid effect obtain mic valu mm result may provid ration support design medic gauz product includ gauz pad roll spong | D000890;D053768 | T121;T073 |
36,235,216 | eco friend synthesi oxovanadium iv bis abiet complex antimicrobi action search less expens viabl product alway one challeng research develop common synthesi coordin compound involv expens ligand expens low yield rout addit generat toxic unus residu work organ ligand use deriv resin reforest tree pinus elliottii var amp nbsp elliottii synthesi method use pinus resin aqueous solut vanadium iii chlorid temperatur c procedur involv organ solvent generat toxic residu thus impart complex format reaction green chemistri charact synthesi result unpreced oxovanadium iv bis abiet complex character mass spectrometri ms chemic analysi chn vibrat ftir electron spectra visibl x ray diffract xrd thermal analysi tgdta colorimetr studi perform accord cielab color space structur formula found consist complex contain two abiet ligand vo c h vo iv bis abiet complex appli microorgan show promis result antibacteri antifung activ best result inhibitori action strain gram posit bacteria aureus l monocytogen minimum inhibitori concentr mic valu mol l respect gram negat strain result mol l e coli mol l salmonella enterica typhimurium antifung activ perform candida albican mic mol l c tropicali mol l accord mfc analysi complex present addit fungistat action fungicid action growth fungi plate test result found test demonstr vo iv bis abiet complex great potenti antimicrobi main antifung agent way pigment ink antimicrobi activ could use environ potenti risk contamin prevent spread microorgan harm health | D000890;D000935 | T121;T195 |
36,235,215 | profici one step heat synthesi manganes sulfid quantum dot solar cell applic necess develop renew energi resourc high durabl flexibl superior energi densiti capacit abil attract consider interest field solar cell research semiconduct compound materi easili avail hazard free cost effect emerg potenti solut tackl challeng herein present multipl molecular precursor use grow manganes sulfid nanoparticl profici one step heat approach test sampl x ray diffract peak correspond mns hexagon wurtzit structur uv vis spectroscopi yield absorpt wavelength nm band gap energi ev photoluminesc analysi show characterist red blue shift nm high resolut transmiss electron microscopi hrtem select area electron diffract sa reveal narrow size distribut nanostick larg contact area critic improv catalyt perform current studi provid improv pathway well grown uniform nanocryst structur applic energi devic | D045663 | T073 |
36,235,214 | green prepar antimicrobi coordin polym zn bipi cl zn bipi oac ultrason zn ii salt bipyridin report green prepar one dimension metal coordin polym sonochem approach spacer ligand bipyridin ultrason chlorid acet zinc salt obtain zn bipi cl zn bipi oac respect benign solvent ethanol water select reaction media synthesi took place minut short time compar convent method day synthesi requir x ray powder diffract fourier transform infrar spectroscopi thermal analysi thermogravimetr differenti scan calorimetri chn techniqu investig influenc use differ reaction solvent chemic structur thermal properti final product zn bipi cl zn bipi oac polym agreement structur report literatur obtain form nanocryst averag crystal size around nm proof concept set gram posit staphylococcus aureus gram negat bacteria klebsiella pneumonia three yeast strain candida albican candida krusei candida glabrata test evalu antimicrobi activ coordin polym follow kirbi bauer procedur micropl dilut method thus minimum inhibitori concentr mic minimum bactericid concentr mbc minim biofilm inhibitori concentr mbic evalu except candida krusei compound show appreci antimicrobi antibiofilm activ strain grown liquid medium | D000890;D011108 | T121;T104;T122 |
36,235,213 | effect hydrogen peroxid vitro cultur tea camellia sinensi l grown dark light morpholog content malondialdehyd accumul various polyphenol tea plant camellia sinensi l phenol accumul crop wide use public health heal effect tea leaf product due biosynthesi phenol compound pcs flavan p vitamin capillari strengthen activ due limit habitat valu special metabolit phenol natur promis approach establish vitro cultur retain abil form pcs characterist ex vivo tea plant aim studi investig effect exogen h mm mm mm growth morpholog degre stress respons accumul various phenol compound tea plant callus cultur differ age day grown differ cultiv condit dark light accord result obtain h effect tea callus cultur differ age caus chang morphophysiolog characterist h exposur rapid respons callus cultur rrcc h delay respons callus cultur drcc determin malondialdehyd mda content serv indic chang level lipid peroxid lpo presenc stress respons plant cell indic either mainten control level decreas increas effect depend growth condit tea callus cultur dark light age durat exposur rapid delay respons h concentr similar trend note total content pcs well amount flavan proanthocyanidin solubl insolubl form lignin plant cell respons reflect chang adapt program special metabolit act target action h therebi contribut increas resist | D028241;D044945 | T121;T109;T002 |
36,235,212 | identif quantif anthocyanin catechin compound purpl tea leav flake tea first popular beverag worldwid avail sever select black fulli oxid oolong partial oxid green non oxid addit purpl tea emerg varieti deriv tea plant camellia sinensi studi investig purpl tea leav non oxid flake water extract thorough identifi composit anthocyanin catechin studi effect water extract process composit properti comparison green tea anthocyanin catechin compound separ quantifi use uplc ident confirm use lc msms posit negat ionize mode delphinidin princip anthocyaninidin purpl tea cyanidin came second major anthocyanin pigment purpl tea delphinidin coumaroyl hexosid follow delphinidin galactosid cyanidin coumaroyl hexosid water extract process result substanti reduct anthocyanin purpl tea flake anthocyanin compound detect green tea sampl purpl green tea type rich catechin green tea contain higher concentr purpl tea main catechin purpl green tea epigallocatechin gallat egcg follow either epicatechin gallat ecg epigallocatechin egc subject tea type extract process increas concentr catechin purpl green tea flake result suggest purpl tea hold promis make healthi brew natur color antioxid andor function ingredi beverag cosmet healthcar industri due high content anthocyanin catechin | D028241;D002392 | T121;T109;T002 |
36,235,210 | defat seed residu cucumi melo novel renew green biosorb remov select heavi metal wastewat kinet isotherm studi present work aim studi biosorpt two import heavi metal viz pb cr use defat seed residu cucumi melo biosorb studi biosorpt select biosorb carri first time optim sorption carri help taguchi method three influenti experiment factor taken account purpos includ amount sorbent amount sorbat shake time pb maximum sorption found use g sorbent ppm sorbat h shake similar cr maximum sorption use g sorbent ppm sorbat h shake pb highest contribut determin anova given amount sorbat follow amount sorbent least contribut given shake time similar cr highest contribut determin anova given amount sorbat follow amount sorbent least contribut given shake time kinet isotherm studi also perform understand natur adsorpt mechan purpos linear non linear form three sorption isotherm employ includ freundlich langmuir dubnin radushkevich isotherm observ conclud defat seed residu cucumi melo regard novel renew green cost effect biosorb remov heavi metal wastewat | D028463;D019216;D014874 | T131;T168;T002;T196 |
36,235,209 | thermost improv l asparaginas acinetobact soli via consensus design cystein residu substitut extend applic rang l asparaginas food pre process thermost improv enzym essenti herein two non conserv cystein residu easili oxid free sulfhydryl group cys cys acinetobact soli l asparaginas asa screen via consensus design satur mutagenesi combinatori mutat mutant cycq high improv thermost obtain half life min c fold increas compar wild type melt temperatur valu reach c c higher wild type molecular dynam simul structur analysi reveal format new hydrogen bond gln aromat interact tyr form adjac residu result enhanc thermost improv thermost l asparaginas could effici enhanc effect acrylamid inhibit content acrylamid potato chip effici reduc mutant cycq treatment signific higher reduct asa wild type treatment addit investig mechan behind enhanc thermost asa could direct modif l asparaginas expand clinic industri applic | D001215;D003545 | T121;T126;T116;T123 |
36,235,208 | recent advanc detect breast cancer deriv exosom breast cancer common malign tumor women incid secret half patient diagnos middl advanc stage necessari develop simpl effici detect method breast cancer diagnosi improv surviv rate qualiti life breast cancer patient exosom extracellular vesicl secret kind live cell play import role occurr develop breast cancer format tumor microenviron exosom biomark import part breast cancer fluid biopsi becom ideal target earli diagnosi curat effect evalu clinic treatment breast cancer paper sever tradit exosom detect method includ differenti centrifug immunoaffin captur summar focus latest research progress breast cancer exosom detect summar aspect optic electrochemistri electrochemiluminesc aspect review expect provid valuabl guidanc exosom detect clinic breast cancer establish reliabl effici simpl innov method exosom detect breast cancer futur | D001943;D055354 | T191;T026 |
36,235,207 | bio inspir rhamnolipid cyclic lipopeptid chito oligosaccharid confer protect wheat powderi mildew inhibit conidia germin plant protect main base applic synthet pesticid limit yield loss result diseas howev use eco friend strategi sustain plant protect becom necess could contribut control pathogen direct antimicrobi effect andor induct plant resist three differ famili natur bioinspir compound origin bacteri fungal strain evalu protect wheat powderi mildew caus biotroph blumeria gramini fsp tritici bgt thus three bio inspir mono rhamnolipid smrls three cyclic lipopeptid clps mycosubtilin fengycin f surfactin appli individu mixtur f f well chitosan oligosaccharid cos bioa test bgt planta vitro three smrls rh eth c rh est c rh succ c two clp mixtur bioa led partial protect wheat bgt higher inhibitor effect germin bgt spore vitro observ smrls rh eth c rh succ c mycosubtilin two clp mixtur take togeth result reveal molecul could constitut promis tool eco friend agricultur | D000890;D001203;D048271;D010575 | T121;T109;T131;T004 |
36,235,206 | carduus edelbergii rech f mediat fabric gold nanoparticl character evalu antimicrobi antioxid antidiabet potenc synthes aunp due high expens less effect side effect avail synthet medicin research communiti focus phyto base natur bioactiv compound consid safer treatment syndrom chronic diseas | D031177;D003921;D053768 | T050;T073;T002 |
36,235,205 | asymmetr conjug addit keton maleimid organocatalyz chiral primari amin salicylamid enantioenrich substitut succinimid interest compound asymmetr organocatalyt synthesi conjug addit keton maleimid scarc explor studi show enantioselect conjug addit keton maleimid organocatalyz simpl primari amin salicylamid deriv chiral tran cyclohexan diamin provid desir succinimid good excel yield moder excel enantioselect | D000588;D007659 | T109 |
36,235,204 | novel strategi non aqueous bioconjug substitut phenyl triazol dion analogu novel pentafluoro sulfanyl phenyl triazol dion synthesis potenti f radio prosthet group radiolabel peptid protein via select bioconjug phenol side chain tyrosin residu preliminari conjug test reveal rapid hydrolysi semi aqueous condit result led investig electron substitu effect ptad deriv correspond hydrolyt stabil five deriv para substitu vari electron donat withdraw effect synthesis investig bioconjug deriv model tyrosin monitor aqueous organ media presenc varieti catalyst investig found hfip effect catalyst use tandem dcm solvent give ptad tyrosin conjug product f satisfactori good yield wherea analog reaction perform acetonitril unsuccess discoveri system allow success conjug electron defici ptad deriv tyrosin would otherwis unachiev aqueous reaction condit inclus electron defici fluorin ptad deriv use ptad tyrosin conjug hope broaden applic within field f mri pet imag | D010455;D014443 | T121;T123;T116 |
36,235,203 | enzalutamid induc apoptot insult human drug resist sensit glioblastoma cell via intrins bax mitochondrion cytochrom c caspas cascad activ pathway glioblastoma multiform gbm common malign brain tumor temozolomid tmz first line chemotherapeut drug treat gbm howev drug resist still challeng issu gbm therapi preliminari result show upregul androgen receptor ar gene express human gbm tissu studi design evalu effect enzalutamid specif inhibitor ar kill drug resist sensit glioblastoma cell possibl mechan data mine cancer genom atlas tcga databas reveal upregul ar messeng rna protein express human gbm tissu especi male patient compar normal human brain addit express ar mrna protein human tmz sensit u mg resist u mg r glioblastoma cell elev compar normal human astrocyt exposur human u mg u mg r cell enzalutamid concentr time depend decreas cell viabil mechan enzalutamid kill two type glioblastoma cell via apoptot mechan specif exposur enzalutamid augment enzym activ caspas rather caspas moreov enzalutamid success trigger elev level proapoptot bax protein reduct mitochondri membran potenti releas cytochrom c cascad activ caspas dna fragment cell apoptosi human tmz sensit resist glioblastoma cell pretreat z veid fmk inhibitor caspas caus signific attenu enzalutamid induc morpholog shrinkag dna damag apoptot death taken togeth studi show enzalutamid could signific induc apoptot insult human drug resist sensit glioblastoma cell via intrins bax mitochondrion cytochrom c caspas cascad activ pathway enzalutamid potenti drug candid treat gbm target ar signal axi | D001932;D005909 | T191 |
36,235,202 | sequenti inject amperometr system coupl bioreactor line glucos monitor cell cultur applic propos special design sequenti inject si amperometr system coupl bioreactor line glucos monitor cell cultur system compos three main part bioreactor si system electrochem detect unit bioreactor accommod six individu cell cultur unit oper separ differ condit si system enabl automat line sampl line sampl dilut special design mix unit therefor benefit fast analysi time less contamin risk use print microfluid compon mix channel flow cell help reduc oper time sampl volum dispos screen print electrod spe modifi glucos oxidas god carbon nanotub gold nanoparticl use detect develop system provid linear rang mm glucos cell cultur media order work cell cultur higher glucos media line sampl dilut appli develop si system demonstr mous fibroblast l cell cultur result show glucos concentr obtain si system compar obtain convent colorimetr method work develop appli vitro cell base experi biomed research | D015374;D053768;D037742 | T059;T104;T075;T073 |
36,235,201 | fabric encapsul gemini surfact background encapsul surfact innov approach allow protect activ substanc also control gradual releas primarili use protect metal surfac corros creat biolog activ surfac gemini surfact known excel anticorros antimicrobi surfac properti method studi present effici method prepar encapsul gemini surfact form algin gelatin capsul result analysi infrar spectra imag scan electron microscop confirm effect encapsul conclus gemini surfact encapsul form promis candid corros inhibitor antimicrobi possibl protect activ substanc environment factor possibl control outflow | D000890;D013501 | T121;T120;T122 |
36,235,200 | effect biostimul base protein hydrolys rainbow trout oncorhynchus mykiss growth yield wheat triticum aestivum l research object liquid protein hydrolys agromore rainbow trout provid compani russian aquacultur llc purpos studi evalu effect hydrolys agromore biostimul growth yield wheat triticum aestivum l biometr indic wheat triticum aestivum l growth determin laboratori field test laboratori liquid concentr hydrolys dri facilit use agromore promot increas germin sampl compar control sampl well increas length number wheat root biostimul agromore introduc soil liquid form lha lha field test studi show argomore contribut increas length quantiti wheat ear quantiti grain ear seed weight time quantiti product stem increas biostimul agromore increas product respect control sampl general use biostimul agromore spring wheat seed grow season provid increas yield tha tha maximum valu raw gluten content seed higher content control content mass fraction protein seed rang ie higher control sampl thus accord qualit quantit indic total product indic biostimul agromore use increas wheat product reduc use nitrogen fertil | D017686;D014908 | T002;T168;T013 |
36,235,199 | norsesquiterpen glycosid ptaquilosid poison carcinogen compon certain fern previous studi relat ptaquilosid molecul carcinogen secondari metabolit known world fern summaris ptaquilosid pta belong group norsesquiterpen illudan type name illudan refer fungal taxa first repres molecular group identifi ptaquilosid occur main pteridium fern speci although also known fern taxa speci genus pteridium common frequent invas speci contin pta form smaller larger amount organ affect speci effect pta deriv anim human great toxicolog signific basic chemic properti molecul transform first loss sugar moieti ptaquilosin form certain condit dienon deriv pteridienon may aris latter alkyl cyclopropan group certain molecul includ dna anim human organ case dna adduct form later carcinogen effect point mutat scope pta interdisciplinari natur sinc exampl molecul plant biomass enter bodi anim human sever way direct indirect due physico chemic properti excel water solubl pta get plant soil differ water layer pta molecul enter soil main water undergo degrad hydrolyt process import clarifi toxicolog condit given ecosystem estim possibl risk caus pta toxicos diseas anim world main rumin farm anim caus pta briefli describ intak pta contain plant feed sourc caus various syndrom also enter milk meat anim connect toxicolog safeti food chain import investig transport carcinogen pta metabolit organ reassur manner detail global interdisciplinari task present review aim contribut | D002301;D029624;D011042;D032498;D012717 | T121;T109;T131;T002 |
36,235,198 | antioxid hyeronima macrocarpa berri load nanocellulos thermal antioxid stabil studi investig effect differ storag temperatur c bioactiv substanc antioxid properti hyeronima macrocarpa berri load nanocellulos nc extract banana pseudo stem present interest surfac poros properti acidifi ethanol extract show better anthocyanin extract mg cg eq g fw use prepar powder product present intens uniform magenta color cielab paramet l b powder exhibit signific stabil storag temperatur c signific loss anthocyanin decreas antioxid capac addit color stabl month without ad preserv agent anthocyanin rich extract h macrocarpa reach estim shelf life day store c result impregn process extract nc abil protect bioactiv degrad due nc surfac properti | D000975;D005638 | T002;T121;T123;T168;T044;T039 |
36,235,197 | synthesi dihydroxi dimethoxyisoflavanon phytoestrogen derma papilla cell prolif activ paper report concis scalabl method synthesi phytoestrogen dihydroxi dimethoxyisoflavanon via optim synthet rout compound readili obtain step overal yield gram scale commerci avail dimethoxyphenol key featur synthesi includ construct deoxybenzoin unit sequenc claisen rearrang oxid cleavag aryllithium addit effici synthesi isoflavanon architectur high function hydroxyketon | D048789 | T121;T109;T125 |
36,235,196 | immobil nanomateri environment applic nanomateri nms extens use sever environment applic howev widespread dissemin full scale hinder difficulti keep activ engin system thus sever strategi immobil nms environment util establish describ present review emphas role product renew energi remov prioriti pollut well greenhous gase industri stream biolog physicochem process challeng optim applic immobil nms relev research topic consid futur research also present encourag scientif communiti respond current need | D004785;D000074382;D049329 | T131;T073;T197 |
36,235,195 | silicaproteoliposom nanocomposit potenti platform ion channel studi nanostructur solid matric lipid nanoparticl contain membran protein promis tool develop high throughput screen devic sol gel silica deriv nanocomposit load liposom reconstitut kcsa prokaryot potassium channel synthes conform function stabil lipid nanoparticl sol gel immobil character use dynam light scatter steadi state time resolv fluoresc spectroscopi method lipid reconstitut kcsa channel entrap sol gel matrix retain conform stabil chang induc presenc block permeant cation buffer associ conform select filter drop ph associ open activ gate protein henc result indic novel devic potenti use screen platform test new modul drug potassium channel | D008081;D053761 | T109;T073 |
36,235,194 | new benzodioxol compound hypecoum erectum antioxid activ purpos studi identifi chemic compon aerial part hypecoum erectum new benzodioxol deriv identifi hypecoum acid isol togeth three known compound protopin coptisin cryptopin structur identifi base extens spectroscop experi includ nuclear magnet reson nmr high resolut electrospray ionize mass spectra hr esi ms well comparison report literatur meanwhil vitro antioxid activ compound determin use dpph scaveng assay compound ic shown moder antioxid activ | D000975;D021241 | T059;T121;T123;T044;T039 |
36,235,193 | compar variant cell penetr peptid sc design peptid drug conjug herein design synthesi peptid drug conjug pdcs includ differ variant cell penetr peptid sc present first generat seri novel sequenc mutant sc either amino acid delet andor substitut test biolog activ effect histidin substitu found meaning sc uptak cell select moreov build near perfect amphipath structur within shorten sc deriv provid peptid high membran activ also cytotox result promis analog sc e stand due higher uptak efficaci compar parent sc last set experi let peptid react cytotox drug doxorubicin thiol michael addit form novel pdcs result indic sc e could effici drug carrier parent sc biomed applic howev cellular uptak use endocytosi result entrap cargo insid vesicl still major critic step overcom cpp contain peptid drug develop | D000970;D057846 | T121;T109;T116 |
36,235,192 | effect methylthiazol group photoinduc birefring thiazol azo dye host guest system differ wavelength irradi photoinduc birefring behavior host guest system base heterocycl thiazol azo dye differ substitu dispers pmma matrix investig three excit wavelength ie nm nm nm wavelength fell blue side near maximum red side absorpt band tran azo dye respect found photoinduc birefring generat similar extent studi system except system contain methyl benzothiazolyl thiazol azo dye substitu materi achiev birefring valu highest among whole seri regardless excit wavelength moreov identifi optim irradi wavelength effici birefring generat show larg absorpt excit light tran isom account achiev signific degre molecular align obtain result indic thiazol azo dye methyl benzothiazolyl substitu show promis photoinduc birefring consid dye potenti suitabl optic applic | D001391;D013844 | T109;T130 |
36,235,191 | comparison antioxid activ polysaccharid character fresh dri dendrobium officinal kimura et migo general believ fresh dendrobium officinal fdo signific pharmacolog activ dri dendrobium officinal ddo howev differ clear shown studi compar antioxid properti vitro vivo molecular weight arrang monosaccharid composit fresh dendrobium officinal polysaccharid fdop dri dendrobium officinal polysaccharid ddop analyz hplc gpc gc ms result show fdo polysaccharid signific effect scaveng dpph abt hydroxyl radic ddo addit fdo ddo signific reduc lipid peroxid level increas sod aoc cat gsh level mice acut liver damag caus ccl fdo polysaccharid effect histopatholog analysi verifi protect effect dendrobium polysaccharid ccl induc liver injuri determin polysaccharid reveal polysaccharid mannos content fdo signific higher dri counterpart homogen arrang polysaccharid fdo degrad three polysaccharid fragment differ molecular weight ddo overal data identifi differ antioxid activ fdo ddo well reason differ | D031667 | T002 |
36,235,189 | enhanc antioxid anti inflammatori effect self nano microemulsifi drug deliveri system contain curcumin turmer use decad antioxid anti inflammatori effect due activ ingredi isol plant call curcumin howev extrem poor water solubl curcumin often limit bioavail drug aim experiment work improv solubl thus bioavail curcumin develop self nanomicroemulsifi drug deliveri system snmedd labrasol cremophor rh nonion surfact transcutol p co surfact isopropyl myrist oili phase use formul averag droplet size snmedd contain curcumin nm found higher oil content result larger particl size drug load effici formul thermodynam stabl curcumin releas studi ph releas effici rang min result mtt cytotox assay human keratinocyt cell hacat colorect adenocarcinoma cell caco show curcumin contain prepar non cytotox w v accord result diphenyl picrylhydrazyl dpph superoxid dismutas sod assay snedd show signific higher antioxid activ anti inflammatori effect snmedd screen enzym link immunosorb assay elisa snedd formul labrasol surfact reduc tumor necrosi factor alpha tnf interleukin beta il level concentr w w result verifi promis use snmedd deliveri curcumin studi demonstr snmedd could promis altern formul poor solubl lipophil compound low bioavail | D003474 | T121;T109;T130 |
36,235,188 | develop applic hptlc deriv databas identif phenol honey studi report develop valid hptlc deriv databas identifi phenol compound honey two databas set develop contain profil standard compound rich data form rf valu colour hue h nm nm nm derivatis natur product peg reagent nm white light derivatis vanillin sulfur acid reagent max min valu fluoresc max valu uv vis spectra well max valu fluoresc uv vis spectra derivatis use filter paramet identifi potenti match honey sampl spectral overlay system also develop confirm match adopt filter approach use valid databas applic use posit negat control also compar match identifi via hplc dad manuka honey use test honey leptosperin mandel acid kojic acid lepteridin gallic acid epigallocatechin gallat trihydroxybenzo acid anis acid methyl syring identifi honey use hptlc deriv databas | D001688;D006722 | T121;T123;T168 |
36,235,187 | synthesi character biolog evalu silico studi imidazolium pyridinium ammonium base ionic liquid contain n butyl side chain ionic liquid il emerg activ pharmaceut ingredi excel antibacteri biolog activ herein use green chemistri synthesi procedur also known metathesi method develop three seri ionic liquid use methyl butyl imidazolium butyl pyridinium diethyldibutylammonium cation bromid br methanesulfon ch bis trifluoromethanesulfonyl imid ntf dichloroacet chcl co tetrafluorobor bf hydrogen sulfat hso anion spectroscop method use valid structur lab synthes il perform agar well diffus assay use pathogen bacteria caus various infect escherichia coli enterobact aerogen klebsiella pneumonia proteus vulgari pseudomona aeruginosa streptococcus pneumonia streptococcus pyogen scrutin vitro antibacteri activ il establish natur uniqu combin cation anion respons antibacteri activ il among test ionic liquid imidazolium cation ntf hso anion exhibit highest antibacteri activ antibacteri potenti investig silico studi observ bis trifluoromethanesulfonyl imid ntf contain imidazolium pyridinium ionic liquid show maximum inhibit target bacteri strain could util antibiot antibacteri activ float il promis altern exist antibiot antisept | D064751;D000891;D052578 | T120;T121;T197;T103;T104 |
36,235,186 | nir ii aiegen photodynam effect advanc theranost phototheranost concurr integr accur diagnosi eg fluoresc photoacoust pa imag situ therapi eg photodynam therapi pdt phototherm therapi ptt one platform repres attract approach acceler person precis medicin second near infrar window nir ii nm attract consider attent scientif communiti clinic doctor improv penetr depth excel spatial resolut nir ii agent pdt properti well function recent emerg power tool boost phototheranost outcom minireview summar recent advanc photodynam nir ii aggreg induc emiss luminogen aiegen biomed applic molecular design strategi tune electron bandgap photophys energi transform process discuss also highlight biomed applic imag guid therapi subcutan orthotop tumor multifunct theranost combin treatment method includ chemotherapi immunotherapi precis treatment tumor bacteri infect review aim provid guidanc pdt agent long wavelength emiss improv imag precis treatment efficaci hope provid comprehens understand chemic structur photophys properti biomed applic relationship nir ii luminogen | D053758;D009369;D010778 | T191;T061;T073 |
36,235,185 | fluoresc dynam coval polym dna complex templat assembl dynam coval polym dcps offer opportun adapt materi particular interest target sens deliveri biolog molecul view combin cation unit fluoresc unit along dcp chain attract achiev optic probe recognit deliveri nucleic acid report design acylhydrazon base dcps combin cation arginin unit conjug fluoresc moieti base thiophen ethynyl fluoren core two type fluoresc build block bear neutral cation side group fluoren moieti consid order assess role number cation unit complex dna chir optic properti build block dcps complex sever type dna explor provid detail format supramolecular complex stabil aqueous solut dna templat format dcps demonstr provid new perspect assembl fluoresc dcp base nucleic acid structur | D011108;D000080745 | T104;T073;T122 |
36,235,184 | nmr investig interact three non steroid anti inflammatori drug human serum albumin understand interact non steroid anti inflammatori drug human serum albumin play fundament role develop new drug new therapeut strategi sever studi perform nevertheless interact phenomena still fulli understood work high field solut nuclear magnet reson nmr spectroscopi appli compar strength interact diclofenac sodium salt ketorolac tris salt flurbiprofen sodium salt toward albumin aim mono bi select relax rate measur perform appli select puls select frequenc follow magnet recoveri basi depend relax paramet albumin concentr normal affin index calcul sever proton drug affin index diclofenac five fold higher comparison ketorolac flurbiprofen aromat moieti three drug methin proton chiral center ketorolac flurbiprofen involv interact albumin conclus nmr spectroscopi allow comparison drug protein affin also point natur drug site extens involv interact | D004008;D005480 | T121;T109 |
36,235,183 | deep eutect solvent green tool extract bioactiv phenol compound avocado peel avocado peel main agro industri residu generat avocado process rich sourc bioactiv compound like phenol compound grow demand sustain process requir develop new effect method extract bioactiv compound industri wast deep eutect solvent dess new sustain altern toxic organ solvent due non toxic biocompat studi five select dess appli extract bioactiv phenol compound avocado peel extract effici evalu measur total phenol flavonoid content best extract result obtain cholin chlorid acet acid lactic acid mg gaeg dap tpc mg reg dap howev test dess show better extract effici ethanol obtain nade extract high antioxid activ frap mg teg tac mg aaeg synthes dess avocado peel des extract activ test bacteria staphylococcus aureus streptococcus dysgalactia escherichia coli pseudomona putida extract prepar cholin chlorid acet acid lactic acid highest antibacteri activ microorgan result coupl non toxic biodegrad low cost environment friend characterist dess provid strong evid dess repres effect altern organ solvent recoveri phenol bioactiv compound agro industri wast | D001688;D027421 | T121;T002;T123;T168 |
36,235,182 | differ metabolit composit alo barbadensi mill extract lead differenti effect human blood cell activ vitro alo barbadensi mill alo use divers therapeut properti includ immunomodul howev owe composit complex natur alo bioactiv compon respons benefici properti though thought attribut polysaccharid acemannan remain unknown therefor aim determin metabolit composit various commerci alo extract assess effect human blood cell activ vitro peripher blood mononuclear cell pbmc healthi donor stimul polyclon presenc absenc various alo extract cell phenotyp prolifer investig flow cytometri alo extract analyz use target h nmr spectroscopi standard phytochem qualiti character untarget gas chromatographi mass spectrometri gc ms metabolit profil alo extract differ standard phytochem composit vari effect cell activ prolifer apoptosi cell death vitro although relat acemannan content furthermor alo extract distinct metabolit profil extract rich divers sugar sugar deriv associ reduc cell activ result demonstr commerci alo extract uniqu distinct metabolit profil lead differenti effect cell activ vitro independ acemannan content | D000504 | T002 |
36,235,181 | optim sampl prepar microscal separ method high sensit analysi hydrophil peptid optim solid phase extract spe purif chromatograph separ usual neglect proteom studi howev effect detect perform neglig especi work high glycosyl sampl perform compar studi differ spe setup includ hous optim method revers phase chromatograph gradient analysi high glycosyl plasma fraction model sampl glycopeptid analysi hous develop spe method outperform graphit base hydrophil interact liquid chromatographi hilic purif method detect perform recoveri repeat optim chromatographi peak distribut maxim increas peptid detect rate result present sampl purif chromatograph separ method optim analysi hydrophil sampl import heavili n glycosyl protein mixtur | D006108 | T109;T196 |
36,235,179 | absolut configur biolog evalu novel triterpen possibl anti inflammatori anti tumor agent two new compound ardisiapunin b ardisiapunin c isol ardisia lindleyana dietr structur examin use hr esi ms ir nmr spectroscop analys singl crystal x ray diffract ecd calcul found two new compound belong unusu oleanan type triterpen compound bear acet unit c c doubl bond compound bear c aldehyd group c c doubl bond anti inflammatori properti compound test product cellular morpholog use raw cell anti tumor properti test cytotox activ cellular morpholog cell apoptosi cell cycl result show compound exhibit potent cytotox hepg cell line ic furthermor possibl compound inhibit cell prolifer block cell gm phase promot cell apoptosi compound exhibit potenti anti inflammatori activ decreas product lps stimul raw cell compar analysi structur compound reveal acet structur doubl bond posit main differ presum main reason extrem differ cytotox anti inflammatori activ new find two promis lead compound identifi futur develop potenti anti inflammatori anti tumor agent | D000970;D009828;D014315 | T121;T109;T123 |
36,235,178 | antioxid effect bioactiv glass bgs signific tissu engin strategi elev level oxid stress usual observ follow injuri lead impair tissu repair due oxid relat chronic inflamm sever attempt made manag unfavor situat use biomateri antioxid activ show great promis tissu engin regen medicin approach bioactiv glass bgs versatil group inorgan substanc exhibit outstand regen capac hard soft damag tissu chemic composit bgs provid great opportun impart specif biolog activ point bgs may easili becom antioxid substanc simpl physicochem modif exampl particular antioxid element most cerium ce ad basic composit glass hand graft natur antioxid substanc eg polyphenol bg surfac feasibl make antioxid substitut promis result vitro mesopor bgs mbgs demonstr uniqu merit compar melt deriv bgs sinc make possibl load antioxid deliv desir locat howev actual limit vivo experiment studi capabl modifi bgs scaveng free radic eg reactiv oxygen speci ros therefor research requir determin actual potenti bgs decreas oxid stress subsequ improv tissu repair regener present work aim highlight potenti differ type bgs modul oxid stress subsequ improv tissu heal | D000975;D002563 | T121;T109;T123;T196;T044;T039 |
36,235,177 | antioxid antimicrobi silico nadph oxidas inhibit chemic analyz essenti oil deriv ballota deserti juri ballota deserti juri b deserti medicin plant use ayurved medicin chemic composit antioxid antibacteri antifung properti essenti oil b deserti eobd drug resist microorgan examin work hydrodistil use extract eobd gas chromatographi mass spectrometri use identifi constitu ferric reduc antioxid power frap diphenyl picrylhydrazyl dpph total antioxid capac tac use assess antioxid effect eobd disc diffus agar microdilut test use assess antibacteri properti eobd clinic resist pathogen microorgan silico approach use evalu inhibitori potenti eobd nadph oxidas yield eobd primarili compos linalool cineol borneol eobd good antioxid potenc calcul valu gml dpph gml frap g eaa mg tac gram negat gram posit bacteria inhibit eobd inhibit zone rang mm mm eobd exhibit mic rang gml gml test bacteria use minimum inhibitori concentr mic assay similar impress antifung activ observ fungal strain inhibit zone width rang mm result mic assay fungi show eobd mic valu rang gml dock result show thujon cymen butano acid contain eobd possess strong activ nadph oxidas glide score kcalmol respect light find eobd may seen potenti sourc chemic compound signific biolog capabl advantag natur antioxid develop effect weapon wide rang pathogen bacteria | D000890;D031329;D027522;D009822 | T121;T109;T002 |
36,235,176 | qualit analysi multipl phytochem compound tojaprid base uhplc q exact orbitrap mass spectrometri tojaprid compos cauli perilla rhizoma cyperi radix glycyrrhiza citrus aurantium l copti chinensi franch pericarpium citri reticulata reynoutria japonica houtt tetradium ruticarpum cleistocactus sepium effect inhibit gastric acid reliev pain clinic use treat gastroesophag reflux diseas studi pharmacodynam properti tojaprid systemat character chemic constitu tojaprid investig use ultra perform liquid chromatographi q exact orbitrap mass spectrometri combin parallel reaction monitor first time eventu total compound includ flavonoid alkaloid glycyrrhiz acid deriv identifi base chromatograph retent time msms inform bibliographi data total report first time present tojaprid newli develop approach provid power tool extend understand chemic constitu tojaprid extend tcmp composit research | D000470;D004365 | T121;T131;T109;T123 |
36,235,175 | protein novel therapeut target psoriasi autoimmun diseas psoriasi one common inflammatori skin diseas affect popul one characterist abnorm psoriasi excess product antimicrobi peptid protein play essenti role pathogenesi diseas antimicrobi peptid protein express differ normal diseas skin reflect use diagnost biomark moreov due import function innat immun member host defens peptid protein current consid promis new therapeut target mani inflammatori diseas koebnerisin sa belong famili antimicrobi protein constitut multigenet group calcium bind protein involv ion depend cellular function regul immun mechan sa first discov overexpress koebner psoriat skin indic involv diseas phenotyp promis potenti new therapeut target review describ involv antimicrobi peptid protein inflammatori diseas develop therapi discuss focus protein especi koebnerisin may involv under mechan kebner phenomenon psoriasi well immun mediat inflammatori diseas describ last decad | D001327;D011565 | T047 |
36,235,174 | design synthesi biolog evalu novel potent protein arginin methyltransferas inhibitor cancer therapi protein arginin methyltransferas prmt clinic promis epigenet target upregul varieti tumor current sever prmt inhibitor preclin clinic develop howev establish clinic inhibitor show favor toxic thus remain unmet need discov novel structur divers prmt inhibitor character therapeut util herein seri tetrahydroisoquinolin thiq deriv design synthes prmt inhibitor use gsk lead compound among compound ic nm exhibit potent prmt inhibitori activ gsk ic nm addit compound show high anti prolif effect mv mda mb tumor cell low cytotox aml hepatocyt furthermor compound possess accept pharmacokinet profil display consider vivo antitumor efficaci mv xenograft model taken togeth compound antitumor compound worthi studi | D009369;D044005 | T191;T109;T121 |
36,235,173 | current status futur trend remov control mitig alga food safeti risk human consumpt rapid develop economi product increas number citizen concern nutrit valu alga potenti new food resourc also particular pay attent safeti consumpt mani studi report point analyz solv seawe food safeti issu requir holist systemat consider three main factor found affect food safeti algal physic chemic microbiolog hazard time although food safeti awar among food produc consum increas foodborn diseas caus algal food safeti incid occur frequent threaten health live consum may caus irrevers harm treatment done prompt seri studi also prove idea microbi contamin alga main caus problem therefor rapid effici detect toxic pathogen microbi contamin algal product urgent issu need address time two factor physic chemic hazard ignor nowaday detect techniqu main focus three major hazard tradit method howev especi food microorgan use tradit microbiolog control techniqu time consum limit term accuraci recent year two evalu microbi foodborn pathogen monitor farm tabl chain shown import especi covid pandem meanwhil also mani new develop monitor heavi metal algal toxin pollut futur algal food safeti risk assess focus conveni rapid low cost high accuraci detect also connect novel technolog internet thing artifici intellig machin learn biosensor molecular biolog reach purpos simultan detect | D000086382;D004785;D005517 | T047;T131;T067;T037 |
36,235,171 | microneedl one plane bevel tip fabric print process articl present microneedl analys design paramet studi includ length inner outer diamet rang mathemat model also use general outer inner diamet ratio obtain rang follow rang inner outer diamet complet mechan simul rang inner diamet rang outer diamet rang rang mathemat model made use fourth order polynomi regress correl ensur safeti factor four von miss forc microneedl around mpa ansi softwar use analyz mechan behavior microneedl addit microneedl concept made print use bio compat resin class featur present microneedl design studi make promis option implement transderm drug deliveri devic | D016503;D012867 | T022;T074 |
36,235,169 | adult honeybe beeswax indic trace element pollut vulner environ distribut among differ apicultur compart bee search diet sourc intens fli within radius km encount nectar pollen water sourc potenti contamin consequ product provid valuabl inform potenti pollut current studi macro trace element includ hazard one measur bee honey wax pollen larva obtain seven explicit industri area eastern region slovakia use valid icp ms method analys element detect least one matrix detect concentr toxic element hg pb cd case higher wax bee sampl compar honey larva pollen particular pb hg maximum concentr detect wax sampl poa gkg strskea gkg addit adult bee accumul element larva wax adult bee seem suitabl monitor macro trace element surround environ statist analysi emphas bee wax correl cd strske area possibl attribut intensifi industri activ region | D006722;D008628;D014131 | T131;T121;T168;T123;T196 |
36,235,168 | recent advanc natur product base hybrid anti cancer agent cancer one top lead caus death worldwid heterogen diseas character unregul cell prolifer invas abnorm cell treatment cancer natur product wide use sourc therapeut ingredi sinc ancient time although natur compound deriv demonstr strong antitumor activ mani type cancer poor pharmacokinet properti low cell select limit bioavail restrict efficaci drug resist cancer cell hinder wide clinic applic conjug natur product bioactiv molecul given rise new field drug discoveri result develop novel bifunct potent drug cancer therapi overcom current drawback review discuss multipl categori bifunct conjug highlight recent trend advanc develop natur product hybrid among adc pdcs apdc protac autotac repres emerg therapeut agent cancer | D000970;D001688;D018796;D009369 | T121;T191;T109;T123;T129 |
36,235,167 | fluoresc phosphoresc nitrogen contain heterocycl crown ether biolog pharmaceut applic fluoresc molecul absorb photon specif wavelength emit longer wavelength photon within nanosecond recent fluoresc materi wide use life materi scienc fluoresc label heterocycl compound use bioanalyt applic includ vivo imag high throughput screen diagnost light emit diod compound various therapeut properti includ antifung antitumor antimalari anti inflammatori analges activ differ neutral fluoresc marker contain nitrogen heterocycl quinolon azafluoranthen pyrazoloquinolin etc sever electrochem biolog nonlinear optic applic photodynam therapi pdt destroy tumor keep normal tissu safe work presenc molecular oxygen light photosensit drug dye obtain therapeut effect compound potenti effect templat produc devic use biolog research blend crown compound fluoresc residu creat sensor frequent investig floresc heterocycl compound crown ether increas metal solubl non aqueous fluid broaden applic window fluoresc supramolecular polym widespread use fluoresc materi fluoresc probe data storag bio imag drug administr reproduct biocatalysi cancer treatment employ fluorophor includ organ chromophor crown ether high select sensit stabil constant open new avenu research fluoresc organ compound gain import biolog world daili divers function remark structur featur posit properti field medicin photochemistri spectroscopi | D000962;D043844;D015363 | T121;T109 |
36,235,166 | thermodynam thermal properti quercetin similar pharmaceut thermodynam properti pharmaceut major import sinc involv drug design process optim model studi long stand confus regard thermodynam properti flavonoid similar pharmaceut recogn clarifi case studi thermal behavior quercetin examin various techniqu shown quercetin exhibit glass transit melt point contrari exhibit various thermochem transit structur relax occur simultan decomposit inevit physic mean report experiment valu thermodynam properti heat fusion heat capac question discuss behavior focus weaken chemic bond interpret along literatur data suggest thermochem transit might exhibit various flavonoid similar pharmaceut relat difficulti predictionmodel melt point | D005419;D011794 | T121;T109;T127 |
36,235,165 | bioaccess phenol acid flavonoid buckwheat biscuit prepar flour ferment lactic acid bacteria literatur report consumpt common buckwheat fagopyrum esculentum moench exact polyphenol contain associ wide spectrum health benefit therefor determin bioaccess phenol acid flavonoid buckwheat biscuit formul liquid state ferment flour bb f select lactic acid bacteria lab gastrointestin digest address studi bioaccess could defin fraction compound releas food matrix gastrointestin lumen use intestin absorpt bioaccess eight phenol acid protocatechu vanil syring ferul caffeic sinap p coumar cinnam six flavonoid epicatechin vitexin orientin apigenin kaempferol luteolin provid bb f bb c buckwheat biscuit prepar ferment unfer flour respect bioaccess index bi indic high bioaccess phenol acid improv bioaccess flavonoid bb f moreov data provid evid suitabl select lab strain use natur sour agent bakeri product develop rich phenol acid flavonoid lab depend bioaccess | D002392;D019612;D056546 | T002;T007;T121;T109;T168 |
36,235,164 | separ purif two saponin pari polyphylla var yunnanensi macropor resin effect method separ purifi critic saponin polyphyllin ii polyphyllin vii pari polyphylla var yunnanensi extract develop studi environment friend econom static adsorpt kinet thermodynam dynam adsorpt desorpt macropor resin investig condit purif separ optim fit adsorpt thermodynam equat kinet equat effect nka resin seven macropor resin screen separ purifi two saponin static adsorpt dynam adsorpt chemic physic adsorpt dual process nka resin optimum paramet content polyphyllin ii polyphyllin vii product fold fold plant extract respect total yield two saponin research thus provid theoret foundat larg scale industri product natur drug polyphyllin ii polyphyllin vii | D019668;D000070556;D012503 | T109;T002 |
36,235,163 | assess hypoglycem hypolipidem activ flavonoid rich extract angelica keiskei angelica keiskei contain varieti bioactiv compound includ chalcon coumarin phytochem endow pharmacolog effect lipid lower activ antitumor activ liver protect nerv protect studi aim studi hypoglycem hypolipidem effect flavonoid rich extract angelica keiskei feak effort exploit new applic feak increas commerci valu paper flavonoid compound angelica keiskei extract use ethanol content flavonoid compound analyz uplc msms hypoglycem hypolipidem activ feak investig vitro enzym activ cell experi well establish vivo zebrafish caenorhabd elegan c elegan model uplc msms result show major flavonoid compound feak aureusidin xanthoangelol kaempferol luteolin quercetin inhibitori rate feak activ amylas cholesterol esteras respect cell lipid lower experi feak signific reduc total cholesterol tc total triglycerid tg level dose depend manner gml feak decreas intracellular level tc tg respect fluoresc intens feak group higher control group indic feak exhibit hypoglycem effect concentr feak reach gml hypoglycem effect zebrafish reach averag fluoresc intens c elegan feak group lower control group result indic feak hypoglycem hypolipidem activ find studi provid theoret refer high valu util angelica keiskei develop natur function food hypoglycem hypolipidem activ | D029969;D047188 | T109;T002 |
36,235,162 | effect fatti alcohol differ chain length perform low ph biomass base foam radioact decontamin compar polym nanoparticl fatti alcohol increas stabil foam also maintain better foamabl ph lt benefici reduc wast liquid increas decontamin effici radioact surfac pollut howev differ fatti alcohol differ hydrophob chain length effect fatti alcohol differ chain length perform decontamin foam studi ph lt assist select suitabl fatti alcohol foam stabil combin betain surfact phytic acid biomass base foam synthes use fatti alcohol differ chain length hydrophob tail group fatti alcohol surfact foam show best perform includ lowest surfac tension highest liquid film strength greatest sag resist best stabil howev hydrophob tail group differ space adjac surfac activ molecul increas thermal motion excess termin tail segment tail wag effect adsorpt densiti reduc gas liquid interfac lead increas surfac tension decreas liquid film strength sag resist stabil use decontamin foam stabil fatti alcohol hydrophob group surfact found increas decontamin rate radioact uranium pollut vertic surfac | D005233;D014501 | T109;T196 |
36,235,161 | capric acid behav agonist effect calcitriol control inflammatori mediat colon cancer cell inflamm prompt cancer develop promot stage tumorigenesi calcitriol nutraceut essenti regul host health benefit howev influenc calcitriol inflammatori mediat involv cancer cell clear studi aim assess sensit calcitriol alon combin capric acid identifi possibl influenc calcitriol inflammatori mediat colorect cancer cell line hct induc lpstnf inflamm metastat mediat il il il quantifi calcitriol capric acid supplement colon cancer cell mrna protein express mmp nf b cox quantifi signific reduct mmp express confirm combin treatment zymogram analysi find demonstr anti inflammatori anti metastat potenti capric acid calcitriol individu exposur combin human colon cancer cell line hct abil may due inhibit cox mediat nf b transcript factor reciproc regul mmp mmp signal pathway find elucid activ cox nf b via disrupt cellular outer matrix could consid novel molecular target suitabl colorect cancer therapi studi confirm capric acid activ calcitriol sensit colon cancer cell could use success supplement intestin diseas colon aberr | D003110;D018836 | T191;T121 |
36,235,160 | novel util water extract suaeda salsa pdc catalyz suzuki miyaura coupl reaction use biomass deriv solvent various organ reaction challeng fine chemic industri herein report pdc catalyz suzuki miyaura reaction water extract suaeda salsa wes without use extern phosphin ligand base organ solvent cross coupl reaction carri basic wes medium broad substrat scope wide function group toler furthermor high puriti solid biaryl product obtain column chromatographi filtrat | D019663;D010165 | T196;T002 |
36,235,159 | effect extract flavonoid drosera rotundifolia l ciliari beat frequenc murin airway smooth muscl extract drosera rotundifolia tradit use treat cough symptom common cold present studi aim investig impact extract rotundifolia activ compound respiratori tract tracheal slice cbln mice use ex vivo examin effect airway smooth muscl asm ciliari beat frequenc cbf phosphodiesteras pde inhibit assay carri test whether pde pde target activ compound ethanol water extract well aqueous fraction extract exert antispasmod properti acetylcholin induc contract addit contract induc mm k abrog aqueous fraction effect asm could attribut flavonoid quercetin galloylhyperosid hyperosid moreov drosera extract aqueous fraction increas cbf murin tracheal slice quercetin galloylhyperosid identifi activ compound involv elev cbf compound inhibit pdea pded elev cbf mimick subtyp select pde inhibitor rolipram pde methoxymethyl ibmx summari studi show first time drosera extract flavonoid compound increas cbf murin airway antispasmod effect transfer asm | D029787 | T002 |
36,235,158 | compar proteom potato cultivar variabl dormanc period control durat dormanc phase signific challeng potato industri seed produc howev proteom landscap involv regul length dormanc period potato cultivar remain larg unexplor studi perform first time compar proteom profil potato cultivar differenti durat tuber dormanc specif proteom profil agata kennebec agria commerci potato varieti short medium medium long dormanc respect assess endodorm stage use high resolut two dimension electrophoresi de coupl revers phase liquid chromatographi tandem mass spectrometri lc tripletof msms total proteinsisoform statist signific differenti abund among cultivar detect de gel confid identifi lc tripletof msms identifi protein known function relat tuber develop sprout oxylipin biosynthesi pathway fructokinas mitochondri adpatp carrier catalas isozym heat shock kda protein strongest respons dormanc variat best knowledg studi report first candid protein under variabl dormanc length potato cultivar | D011198 | T168;T002 |
36,235,157 | prepar character ancient aminopeptidas obtain ancestr sequenc reconstruct l carnosin synthesi biolog activ peptid l carnosin wide use pharmaceut cosmet health care industri due various physiolog properti howev relat littl research avail regard l carnosin enzymat synthesi function studi potenti enzym sequenc function carnosin synthes screen use ancestr sequenc reconstruct asr techniqu identifi l carnosin synthesi activ enzym confirm use autoproteolyt phenomenon via western blot n termin sequenc purif enzymat properti luca dmpa character melt temperatur tm denatur enthalpi h luca dmpa c kjmol respect circular dichroism cd spectroscopi result show ancestr enzym compos helix sheet turn random coil enzym character optim temperatur ph c respect notabl luca dmpa also character remark ph toler base observ remain enzymat activ incub differ ph buffer ph h addit rather improv inhibit metal ion enzymat activ found promot introduc organ solvent larger log p valu base homolog model result screen luca dmpa suggest optim potenti thereaft offer promis candid real industri applic | D002336 | T121;T109;T123;T116 |
36,235,156 | structur variat central heterocycl scaffold tripartit difluorobenzamid influenc antibacteri activ mdr staphylococcus aureus five seri heterocycl tripartit difluorobenzamid name triazol oxadiazol analog report model anti staphylococc compound prepar purpos investig influenc natur heterocycl central scaffold biolog activ three strain aureus includ two drug resist one among compound new collect tert butylphenyl oxadiazol link via methylen group difluorobenzamid moieti iic exhibit minim inhibitori concentr gml accord strain subsequ studi iic demonstr human cytotox target bacteri divisom | D055624;D013203 | T007;T047 |
36,235,155 | review phytochemistri pharmacolog fruit siraitia grosvenorii swingl tradit chines medicin food siraitia grosvenorii swingl c jeffrey ex lu et z zhang uniqu econom medicin plant cucurbitacea southern china hundr year chines peopl use fruit grosvenorii excel natur sweeten tradit medicin lung congest sore throat constip one first speci china classifi medicin food homolog receiv consider attent natur product high develop potenti various natur product triterpenoid flavonoid amino acid lignan releas plant previous phytochem studi phar macolog research fruit grosvenorii attract extens attent increas number extract compound demonstr antituss expector antiasthmat antioxid hypoglycem immunolog hepatoprotect antibact rial activ review base larg number previous studi summar relat research progress chemic compon pharmacolog effect grosvenorii provid theoret support investig biolog function potenti clinic applic | D018927;D000996;D001688;D019662;D017705;D014315 | T002;T121;T109;T123;T168 |
36,235,154 | lebanes red alga jania ruben promis biomolecul colon cancer cell colorect cancer crc rank second lethal type tumor global thus develop novel anti cancer therapeut less aggress potent need recent natur bioactiv molecul gain interest complementari support antineoplast treatment due safeti effect low cost jania ruben j ruben red coral seawe abund mediterranean bear signific pharmacolog essenc despit therapeut potenti natur biomolecul extract alga poor identifi studi proxim analysi reveal high level total ash content protein carbohydr lipid element identif show magnesium calcium high among macro miner mgg mgg respect chlorophyl j ruben domin pigment mgg diphenyl picrylhydrazyl dpph radic scaveng assay identifi effect antioxid activ various j ruben extract import dimethylthiazol yl diphenyltetrazolium bromid mtt tetrazolium reduct wound heal assay indic organ extract j ruben signific counteract prolifer colon cancer cell line hct ht inhibit migratori metastat properti dose time depend manner overal studi provid insight physicochem properti red seawe j ruben identifi signific antioxid cytotox anti migratori potenti two colorect cell line hct ht | D000970;D003110;D009822;D000461;D012624 | T002;T121;T191;T109;T204 |
36,235,153 | pomegran flower extract health promot properti optim applic box behnken design herbal raw materi antidiabet activ valuabl support therapi optim extract process allow best possibl health promot effect box behnken design employ optim content methanol use extract mixtur time temperatur aim studi enhanc effici pomegran flower extract process order obtain extract highest enzym inhibit power amylas glucosidas import antidiabet effect highest antioxid activ dpph assay box behnken design model content pelargonidin glucosid anthocyanin compound associ antidiabet activ also optim variabl associ action profil pomegran flower extract process optim carri studi provid basi research use pomegran flower extract potent desir properti essenti support diabet treatment base pomegran flower | D000872;D000079702 | T121;T109 |
36,235,151 | product minor ginsenosid panax notoginseng flower cladosporium xylophilum panax notoginseng flower highest content saponin compar part panax notoginseng minor ginsenosid higher pharmacolog activ main natur ginsenosid therefor studi focus transform main ginsenosid panax notoginseng flower minor ginsenosid use fungus cladosporium xylophilum isol soil main ginsenosid rb rb rb rc notoginsenosid fa panax notoginseng flower transform ginsenosid f rd notoginsenosid fd fe ginsenosid r convers rate respect transform product studi tlc hplc ms analys biotransform pathway major ginsenosid propos addit purifi enzym fungus prepar molecular weight kda transform monom ginsenosid crude enzym consist fungus addit three saponin isol transform product identifi ginsenosid rd notoginsenosid fe fd nmr ms analys studi provid uniqu power microbi strain effici transform major ginsenosid p notoginseng flower minor ginsenosid help rais function econom valu p notoginseng flower | D036145;D005894;D053723;D012503 | T121;T109;T002 |
36,235,150 | selenium antioxid critic role anti age age character imbal damag inflict reactiv oxygen speci ros antioxid defens organ signific nutrit factor trace element selenium se may remodel gradual spontan physiolog chang caus oxid stress potenti lead diseas prevent healthi age se involv improv antioxid defens immun function metabol homeostasi inadequ se status may reduc human life expect acceler age process increas vulner various disord includ immun dysfunct cancer risk review highlight avail studi effect role se age mechan show potenti clinic implic relat consumpt main sourc organ se advantag nanoformul also discuss | D012643;D014131 | T121;T123;T196 |
36,235,149 | symmetri break charg transfer dna templat perylen dimer aggreg molecular aggreg interest broad rang field includ light harvest organ optoelectron nanoscal comput molecular aggreg nonradi decay pathway may emerg present constitu molecul nonradi decay pathway may includ singlet fission excim relax symmetri break charg transfer singlet fission sometim refer excit multipl great interest field energi convers quantum inform exampl endotherm singlet fission avoid energi loss observ coval bound linear perylen trimer tetram work electron structur excit state dynam dimer perylen deriv templat use dna investig specif dna holliday junction use templat aggreg two perylen molecul coval link modifi uracil nucleobas ethynyl group perylen templat form monom transvers dimer adjac dimer configur electron structur perylen monom dimer character via steadi state absorpt fluoresc spectroscopi initi insight excit state dynam glean relat fluoresc intens measur indic new nonradi decay pathway emerg dimer femtosecond visibl transient absorpt spectroscopi subsequ use elucid excit state dynam new excit state absorpt featur grow ten picosecond timescal dimer attribut format perylen anion cation result symmetri break charg transfer given close proxim requir symmetri break charg transfer result shed promis light prospect singlet fission dna templat molecular aggreg | D010569 | T109;T131;T130 |
36,235,148 | comprehens review synthesi properti applic phosphorus p iii p iv p v substitut acen two fuse benzen ring comprehens review cover year retrospect investig certain group linear fuse aromat call acen also present current state knowledg synthesi reaction applic compound characterist featur substitut aromat system one two three organophosphorus group determin properti applic p iii p iv p v phosphorus atom organophosphorus group link acen direct p c sp bond indirect oxygen atom p c sp bond | D001554;D010758 | T109;T131;T197;T196 |
36,235,147 | structur requir hag peptid ddfvfyvggyp laminin chain amyloid like fibril format cell adhes hag peptid ddfvfyvggyp identifi human laminin chain g domain promot cell attach spread direct coat plastic plate show activ conjug chitosan matrix focus structur requir hag activ hag stain congo red form amyloid like fibril delet analysi hag reveal fvfyv minimum activ sequenc format amyloid like fibril fvfyv promot cell attach next design function fibril use fvfyv templat amyloid like fibril conjug integrin bind sequenc arg gli asp rgd fvfyv peptid gli gli gg spacer fvfyvggrgd promot cell attach plate coat assay negat control sequenc rge conjug peptid fvfyvggrg also show activ howev peptid conjug sepharos bead fvfyvggrgd bead show cell attach activ fvfyvggrg bead result suggest rgd rge similar contribut cell attach activ amyloid like fibril rgd contribut activ sepharos bead conjug basic amino acid arg lys fvfyv peptid arg lys conjug fvfyv peptid fvfyvggr fvfyvggk show cell attach activ coat plate conjug fvfyv peptid fvfyvggh show activ none basic amino acid conjug peptid show cell attach sepharos bead assay cell attach spread fvfyvggr fvfyvggk inhibit anti integrin antibodi result suggest arg lys residu play critic role interact integrin amyloid like fibril fvfyv use use templat amyloid like fibril develop multi function biomateri | D048271;D003224 | T121;T109;T130 |
36,235,146 | anti ovarian cancer conotoxin identifi conus venom conotoxin constitut treasuri drug resourc attract widespread attent order explor biolog candid marin cone snail isol identifi three novel conopeptid name vib vi vi three conotoxin variant name mrd mre txa three known conotoxin via mr tcp crude venom conus virgo conus marmoreus conus texil mr v ii vi iii iv txa iii ii vi iv v show novel pattern disulfid connect differ previous establish conotoxin concern effect voltag gate sodium channel mre mr txa tcp inhibit na v na v current semi activ state tp moll certain anti ovarian cancer effect id cell exhibit txa mre vib ic valu respect work highlight role conotoxin librari subsequ drug discoveri ovarian cancer treatment | D020916;D052078;D009369 | T116;T131;T191;T123;T204 |
36,235,145 | role nanotechnolog overcom multidrug resist cancer therapi review cancer one lead caus morbid mortal around globe like becom major caus global death come year per world health organ report everi year million new case death diseas chemotherapi radiotherapi surgeri three basic approach treat cancer approach aim erad cancer cell minimum target effect cell type drug serious advers effect due lack target select hand resist alreadi avail drug emerg major obstacl cancer chemotherapi allow cancer prolifer irrespect chemotherapeut agent consequ lead multidrug resist mdr grow concern scientif communiti overcom problem recent year nanotechnolog base drug therapi explor shown great promis overcom resist nano base drug explor clinic level review tri explain various mechan involv multidrug resist cancer role nanotechnolog play overcom revers resist | D000970;D009369 | T121;T109;T191 |
36,235,144 | deep eutect solvent altern solvent biomass base wast valor innov technolog transform consid wast stream feedstock rang product inde use biomass sourc biopolym chemic current consolid econom dimens well develop regul market evalu manufactur process reli specif criteria puriti yield respect defin regulatori paramet process safeti context ionic liquid deep eutect solvent propos environment friend solvent applic relat biomass wast valor mini review draw attent recent advanc use seri new solvent technolog emphasi deep eutect solvent dess key player develop new process biomass wast valor work aim highlight role import dess follow three strateg area chitin recoveri biomass isol valuabl chemic biofuel biomass wast stream | D052578 | T103;T120 |
36,235,143 | thin layer chromatographi tlc screen botan versatil potenti select applic aim paper present comprehens overview main aim scope screen botan task thin layer chromatographi tlc everyday basi confront engag stun omnipres modest analyt techniqu standard format tlc high perform one hptlc either hyphen mani analyst might first glanc appear chaotic random auxiliari rather lead role research capabl issu meaning final statement base reflect purpos present general review paper tlc screen botan blueprint rather illustr select practic exampl highlight sovereign import role tlc accomplish follow analyt task solv puzzl relat chemotaxonomi plant ii screen wide spectrum biolog properti plant iii provid qualiti control herbal medicin alimentari cosmet product biolog origin iv trace psychoact plant forens surveil | D010946 | T002 |
36,235,142 | virtual extens read across new open access softwar chemic read across applic carcinogen assess botan read across appli principl similar identifi similar substanc repres given target substanc data poor situat howev differ target sourc substanc exist present studi aim screen assess effect key compon molecul may escap evalu read across base similar substanc use new open access softwar virtual extens read across vera vera provid mean assess similar chemic use structur alert specif properti pre defin molecular group structur similar softwar find similar compound certain featur eg structur alert molecular group provid cluster similar substanc compar similar substanc within differ cluster carcinogen complex endpoint sever mechan requir resourc intens experiment bioassay larg number anim use read across part new approach methodolog would support carcinogen assess test vera softwar carcinogen select endpoint interest rang botan vera correct label botan indic similar substanc main featur associ carcinogen | D012984 | T090;T170;T073 |
36,235,141 | synthesi inhibitori activ machaeridiol base novel anti mrsa anti vre compound profil cancer relat signal pathway three uniqu seco hexahydrodibenzopyran seco hhdbp machaeridiol c report previous machaerium per display potent activ methicillin resist staphylococcus aureus mrsa vancomycin resist enterococcus faecium e faecali vre order enrich pipelin natur product deriv antimicrobi compound seri novel machaeridiol base analog prepar coupl stemofuran pinosylvin resveratrol legend monoterpen unit r phellandren p mentha dien ol geraniol inhibitori activ profil mrsa atcc vre atcc cancer signal pathway compound show strong vitro activ mic valu gml gml mrsa respect gml vre geranyl analog found moder activ mic gml reduct doubl bond monoterpen unit compound result antibacteri potenc mic gml gml parent furthermor combin studi seco hhdbp hhdbp machaeriol c display synergist effect fraction inhibitori concentr fic valu mrsa show four fold decreas mic valu machaeriol c effect observ vancomycin compound test vivo nosocomi mrsa singl intranas dose mgkg murin model compound efficaci condit final compound profil panel luciferas gene assess activ complex cancer relat signal pathway ie transcript factor use tg glioblastoma multiform cell among compound test geranyl substitut analog exhibit strong inhibit sever signal pathway notabl smad myc notch ic valu respect contrast anti mrsa activ found inact ic gt across panel cancer signal pathway | D000890;D001688;D055624;D009369 | T121;T007;T123;T191 |
36,235,140 | portabl wireless intellig electrochem sensor ultrasensit detect rutin use function black phosphoren nanocomposit build portabl sensit method monitor concentr flavonoid rutin new electrochem sens procedur establish use nitrogen dope carbon polym dot n cpds anchor layer black phosphoren n cpds flbp heterostructur gold nanoparticl aunp modifi carbon ionic liquid electrod screen print electrod spe use substrat electrod construct convent electrochem sensor portabl wireless intellig electrochem sensor respect electrochem behavior rutin fabric electrochem sensor explor detail analyt perform investig due electroact group rutin specif stack cation interact nanocomposit rutin electrochem respons rutin great enhanc aunpsn cpds flbp modifi electrod optim condit ultra sensit detect rutin could realiz aunpsn cpds flbpspe detect rang nmol l mol l detect limit nmol l sn final two kind sensor appli test real sampl satisfactori result | D052578;D053768;D053761 | T103;T073;T120 |
36,235,139 | novel yellow azo pyridon deriv differ halid atom imag sensor color filter novel yellow azo pyridon dye deriv synthes use imag sensor color filter synthes compound basic chemic structur compos azo hydroxi amid nitril group well differ halid group new materi evalu basi optic thermal surfac properti condit mimick commerci devic fabric process comparison relat perform reveal among four prepar compound dichlorocyclohexa dien yl diazenyl hydroxi dimethyl oxo dihydropyridin carbonitril cl pamopc exhibit best perform imag sensor color filter materi includ solubl greater wt propylen glycol monomethyl ether acet solvent high decomposit temperatur c stabl color differ valu thermal treatment solvent resist test respect result suggest cl pamopc use green dye addit imag sensor color | D004095;D007287 | T121;T109;T197 |
36,235,138 | state art analyt approach illicit drug profil forens investig forens chemistri investig seiz illicit drug profil chemic fingerprint drug consid fundament involv identif quantit categor drug sampl group provid investig lead common differ origin seiz sampl goal drug profil includ elucid synthet pathway identif adulter impur well identif drug geograph origin specif plant deriv exhibit aim state art review present tradit advanc analyt approach common follow forens chemist worldwid illicit drug profil discuss numer methodolog physic chemic profil organ inorgan impur found illicit drug applic power spectroscop chromatograph tool illicit drug profil includ isotop ratio mass spectrometri irm gas chromatographi mass spectrometri gc ms gas chromatographi isotop ratio mass spectrometri gc irm ultra high perform liquid chromatographi uhplc thin layer chromatographi tlc liquid chromatographi mass spectrometri lc ms induct coupl plasma mass spectrometri icp ms discuss altogeth techniqu cover paper profil seiz illicit drug could aid forens chemist select appli suitabl method extract valuabl profil data | D013287 | T109;T131 |
36,235,137 | influenc polym type qualiti newli develop oral immedi releas tablet contain amiodaron solid dispers obtain hot melt extrus present studi aim demonstr influenc polym carrier type proport qualiti perform newli develop oral immedi releas tablet contain amiodaron solid dispers obtain hot melt extrus twelv solid dispers includ amiodaron differ polym peg peg peg soluplus kolliphor develop prepar hot melt extrus use horizont extrud realiz author laboratori eleven dispers present suitabl physic characterist use activ ingredi eleven tablet formul contain amount excipi vari solid dispers type solid dispers properti establish optic microscopi reflect light volumetr control particl size evalu order prove complex powder appropri physic characterist direct compress process subject differ analys regard flowabl compress behavior addit fourier transform infrar spectroscopi x ray diffract analysi perform obtain solid dispers confirm proper physic attribut blend process form tablet direct compress technolog manufactur tablet evalu pharmacotechn dimens diamet thick mass uniform hard friabil vitro biopharmaceut disintegr time drug releas perform furthermor influenc polym matrix qualiti determin high differ flow compress perform solid dispers prove relev influenc polym type concentr depend plastic properti increas flowabl compress characterist solid dispers could notic combin direct compress excipi own superior mechan qualiti influenc polym type best detect disintegr test obtain valu quit differ studi formul use peg alon combin various proport soluplus lead rapid disintegr contrast mixtur peg poloxam equal proport determin increas disintegr time use poloxam alon combin peg soluplus also generat prolong disintegr time tablet | D000638;D001688 | T121;T109;T123 |
36,235,135 | chang volatil compound short term high co treat seolhyang strawberri fragaria ananassa fruit cold storag seolhyang strawberri harvest fulli ripen treat co extend shelf life howev volatil chang seolhyang strawberri short term co treatment investig although volatil profil import qualiti attribut herein investig effect short term high co treatment chang composit volatil compound seolhyang strawberri two ripen stage ie half red bright red cold storag use headspac solid phase microextract gas chromatographi mass spectrometri furthermor effect co treatment fruit qualiti respect aroma investig total volatil compound identifi storag increas volatil compound concentr total concentr volatil co treat strawberri lower untreat strawberri storag product characterist strawberri volatil eg methoxi dimethyl h furanon inhibit co treat strawberri howev co treatment help maintain concentr hexan hexen respons fresh odor strawberri interest co treatment suppress product odor volatil acetaldehyd hexano acid strawberri storag thus short term co treatment may help maintain fresh aroma strawberri cold storag | D031985;D055549 | T109;T168;T002 |
36,235,134 | green effici determin fluoroquinolon residu edibl green fruit leafi veget ultrasound assist extract follow hplc msms work simpl quick effici analyt method determin human veterinari fluoroquinolon antimicrobi residu lettuc cucumb spinach develop procedur entail min ultrasound assist extract uae min alkalin vv nh aqueous solut contain mg ion ml need organ solvent extract submit cleanup hlb cartridg fluoroquinolon separ quantifi hplc msms min chromatograph run use small amount acetonitril mobil phase method entir develop real matric valid accord updat analyt guidelin provid suitabl recoveri rang precis rsd n differ concentr ng g method quantif limit ng g fluoroquinolon detect quantifi concentr hundr nanogram per gram veget supermarket demonstr applic method monitor residu pharmaceut | D005638;D014675 | T168;T002 |
36,235,133 | mater bond vs multival halogen chalcogen bond three case studi term mater bond recent use refer attract noncoval interact element group act electrophil atom group atom act nucleophil util metal hole donor start attract attent scientif communiti manuscript comparison mater bond well known hole interact halogen chalcogen bond carri use three x ray structur retriev cambridg structur databas csd densiti function theori calcul dft novelti work resid util neutral vii system mater bond donor multival chalcogen halogen donor fact far knowledg extend descript hole interact se vi unpreced literatur hole interact vii se vi cl vii electron acceptor analyz compar use sever comput tool | D018011;D006219 | T196 |
36,235,132 | new advanc later flow immunoassay lfi technolog food safeti detect continu develop china economi societi peopl govern higher higher requir food safeti test food dopant toxin prevent occurr various advers health phenomena world popul deploy new power sensor enabl rapid sens process food industri help detect trace adulter toxic substanc present common food safeti detect method later flow immunochromatographi lfi wide use food safeti test environment test clinic medic treatment advantag simplic speed specif low cost play pivot role ensur food safeti paper main focus applic later flow immunochromatographi new technolog combin test strip food safeti detect aptam surfac enhanc raman spectroscopi quantum dot electrochem test strip detect technolog biosensor test strip detect etc addit sens principl fluoresc reson energi transfer also effect differ method differ characterist follow review applic technolog food safeti detect | D015374;D059022 | T059;T075;T057 |
36,235,131 | two way achiev goal two valid quantit nmr strategi low abund natur product standard extract case hepatodamianol turnera diffusa quantif low abund secondari metabolit plant extract analyt problem address differ analyt platform common base chromatograph method coupl high sensit detect system howev recent year nuclear magnet reson nmr becom analyt tool primari choic type problem reliabl inher simplic sampl prepar reduc analysi time low solvent consumpt versatil strategi base quantit nmr qnmr intern extern standard electron refer among other need develop valid analyt method make essenti compar procedur must rigor satisfi analyt well establish accept criteria method valid work two qnmr method develop quantif hepatodamianol bioactiv compon diffusa first method base convent extern standard calibr second one base puls length base concentr determin pulcon method use eret modul quantit tool avail topspin softwar result show procedur allow content analyt interest complex matrix determin satisfactori way strict analyt criteria addit eret offer addit advantag reduct experiment time reagent consumpt wast generat | D001688;D029647 | T121;T123;T002 |
36,235,130 | grape polyphenol treatment human skelet muscl damag due inflamm oxid stress obes age earli outcom promis today inact high calori diet contribut develop obes prematur age addit popul elder peopl grow due improv healthcar manag obes age togeth key risk factor non communic diseas associ sever co morbid increas mortal major impact skelet muscl defect andor poor muscl mass qualiti skelet muscl contribut multipl bodi function play vital role throughout day activ societi limit skelet muscl deterior frailti depend major public health challeng also major socio econom issu specif diet supplement natur chemic compound grape polyphenol shown play relev direct role regul metabol molecular pathway involv prevent treatment obes age relat muscl comorbid cell cultur anim studi howev clinic studi aim restor skelet muscl mass function nutrit grape polyphenol supplement still scarc urgent need clinic studi valid encourag result observ anim model | D055948;D027843 | T047;T116;T002;T168;T129 |
36,235,129 | tristaenon new anti inflammatori compound isol australian indigen plant tristaniopsi laurina inspir ethnopharmacolog knowledg conduct bioassay guid fraction leav tristaniopsi laurina led discoveri new anti inflammatori compound tristaenon structur elucid detail spectroscop data analysi absolut configur establish use x ray crystallographi analysi tristaenon suppress lps ifn induc tnf il product raw cell ic valu respect also inhibit nf b nuclear transloc concentr | D008070;D016328 | T109;T116;T129 |
36,235,128 | natur phytocompound common indian spice identif three potenti inhibitor breast cancer molecular model approach breast cancer second common cancer relat caus death women throughout globe spite effect measur main concern tradit anti cancer chemotherapi low bioavail physic side effect acquir resist cancer cell non specif target research taken initi establish natur product base therapi method identifi viabl hit futur lead optim develop breast cancer medic studi aim identifi potent phytocompound five popular indian spice zingib officinal rosco cuminum cyminum l piper nigrum l curcuma longa l allium sativum l spice total phytocompound identifi screen three target gene name cyclin depend kinas cdk progesteron receptor pr epiderm growth factor receptor egfr structur base virtual screen use igemdock softwar base bind affin score top three phytocompound target protein cynarosid kcalmol apigetrin kcalmol curcumin kcalmol cdk apigetrin kcalmol cynarosid kcalmol xyloglucan kcalmol pr cynarosid kcalmol apigetrin kcalmol xyloglucan kcalmol egfr select apigetrin cynarosid curcumin xyloglucan final identifi dock analysi respect three target protein autodock appli screen optim bind posit assess relat intens bind interact addit admet properti check bioactiv score analysi perform understand suitabl four phytocompound potenti candid develop effect non toxic anticanc agent base silico analysi believ studi could contribut current effort develop new drug treat breast cancer | D000970;D001943;D003474 | T121;T109;T130;T191 |
36,235,127 | effect donepezil treatment brain metabolit gut microbiota gut metabolit amyloid beta induc cognit impair mous pilot model accumul clinic biomed evid indic gut microbiota metabolit affect brain function behavior various central nervous system disord studi perform investig chang brain metabolit composit fecal microbi communiti follow inject amyloid donepezil treatment inject mice use metataxonom metabolom treatment caus cognit dysfunct donepezil result success recoveri memori impair donepezil group show signific higher relat abund verrucomicrobia group relat abund taxa includ blautia akkermansia differ signific group donepezil group higher level oxal glycerol xylos palmitol fece oxal pyroglutam acid hypoxanthin inosin brain tissu group level pyroglutam acid glutam acid phenylalanin show similar chang vivo vitro use ht cell major metabol pathway brain tissu gut microbiota affect donepezil treatment inject mice relat amino acid pathway sugar metabol respect find suggest alter gut microbiota might influenc induct amelior induc cognit dysfunct via gut brain axi studi could provid basic data effect donepezil gut microbiota metabolit induc cognit impair mous model | D000544;D060825;D000069196 | T007;T001;T047;T048 |
36,235,126 | vitro vivo character zirconium label lintuzumab molecul object positron emiss tomographi pet imag power non invas method determin vivo behavior biomolecul determin biodistribut pharmacokinet pk properti target therapeut enabl better understand vivo drug mechan tumor uptak target accumul clearanc zirconium zr readili avail tetraval pet enabl radiomet use evalu biodistribut pk monoclon antibodi current studi perform vitro vivo character zr lintuzumab radiolabel anti cd antibodi model evalu vivo bind properti preclin model aml method lintuzumab conjug p scn bn deferoxamin dfo label zr use ci g specif activ c h biolog activ zr lintuzumab evalu panel cd posit cell use flow cytometri fox chase scid mice inject oci aml cell right flank day cohort mice n inject zr lintuzumab via tail vein petct scan mice acquir day post zr lintuzumab inject demonstr zr lintuzumab specif bind cd express tumor vivo block studi perform cohort mice n inject nativ lintuzumab h later zr lintuzumab administ group imag day inject zr lintuzumab full ex vivo biodistribut studi cohort perform day result pet imag ex vivo biodistribut studi compar result lintuzumab success radiolabel zr result radiochem yield zr lintuzumab radioconjug specif bind cd posit cell similar manner nativ lintuzumab observ flow cytometri pet imag reveal high accumul zr lintuzumab oci aml tumor within h post inject radioconjug zr lintuzumab high tumor uptak remain day tumor analysi pet data use volum interest voi show signific block zr lintuzumab group pre treat nativ lintuzumab pre block group thus indic specif target cd oci aml cell vivo tumor uptak find pet imag studi agreement ex vivo biodistribut result conclus pet imag zr lintuzumab show high specif uptak cd posit human oci aml tumor result imag studi agre observ ex vivo biodistribut studi find collect suggest pet imag use zr lintuzumab could power drug develop tool evalu bind properti anti cd monoclon antibodi preclin cancer model | D003676;D015040 | T121;T109;T123;T196;T130 |
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