PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,667 | potenti connect molecular chang biomark relat al develop regener cns neurodegen diseas one greatest medic burden modern age most incur limit prognost diagnost tool amyotroph later sclerosi al fatal progress neurodegen diseas character loss motoneuron complex etiolog combin genet epigenet environment caus neuroprotect therapeut approach limit diagnost reli clinic examin exclus diseas recent advanc discoveri molecular pathway gene mutat involv al deepen understand diseas patholog open possibl new treatment diagnost procedur recent risk loci distinct genet architectur neuron specif biolog identifi link al common rare variant associ analys interest quantiti relat protein gene found chang earli postnat develop mammalian spinal cord tissu opossum monodelphi domestica particular time neuroregener stop possibl discuss possibl al relat genesprotein could connect neuroregener develop moreov sinc regul gene express development checkpoint frequent regul non code rnas propos studi chang composit quantiti non code rna molecul al patient develop central nervous cns system opossum time neuroregener ceas could reveal potenti biomark use al prognosi diagnosi | D000690;D019636 | T047 |
36,232,666 | evalu safeti qualiti life colorect cancer patient treat autolog immun enhanc therapi aiet vinmec intern hospit colorect cancer crc increas preval diseas high mortal rate recent year immun cell base therapi receiv massiv attent among scientist proven effect low toxic treatment studi evalu safeti effect autolog immun enhanc therapi aiet crc amp nbsp open label singl group studi includ twelv patient diagnos stage iii iv crc conduct januari decemb twelv crc patient receiv one seven infus natur killer nk cell cytotox lymphocyt ctl multivari model use identifi factor associ health relat qualiti life hrqol score amp nbsp day cultur nk cell increas fold account cultur cell popul likewis ctls account cultur cell popul fold increas furthermor qol improv increas eortc qlq c score decreas symptom sever reduc impair daili live caus symptom mdasi gi report final month increas mean surviv time observ studi complet amp nbsp aiet demonstr safeti improv surviv time hrqol crc patient vietnam | D015179;D011788 | T191;T078 |
36,232,665 | synthet non code rna suppress mtor translat prevent renal fibrosi relat autophagi uuo mous model global burden chronic kidney diseas increas major diseas progress special site target drug emerg altern tradit drug oligonucleotid odn propos effect therapeut tool specif molecular target therapi sever diseas design ring type non code rnas ncrnas also call mtor odn suppress mammalian target rapamycin mtor translat mtor signal associ excess cell prolifer fibrogenesi studi examin effect mtor suppress chronic renal injuri explor regul fibrosi inflamm unilater ureter obstruct uuo induc injuri inject synthes odn via tail vein mice express inflammatori relat marker interleukin tumor necrosi factor fibrosi smooth muscl actin fibronectin decreas synthet odn addit odn administr inhibit express autophagi relat marker microtubul associ protein light chain beclin autophagi relat gene confirm ring type odn inhibit fibrosi inflamm autophagi uuo mous model result suggest mtor may involv regul autophagi fibrosi regul mtor signal may therapeut strategi chronic renal injuri | D051436;D014517 | T047 |
36,232,664 | theoret explan rariti antibodi depend enhanc infect ade covid global vaccin sar cov virus prove high effect howev possibl antibodi depend enhanc infect ade upon vaccin remain underinvestig aim theoret determin condit occurr ade covid develop seri mathemat model antibodi respons model ab model antibodi format model cv model infect spread bodi complet model combin two other model describ experiment data sar cov sar cov infect human cell cultur includ viral load dynam seroconvers time antibodi concentr kinet model reveal signific proport macrophag becom infect bind antibodi high probabl thus high probabl macrophag infect suffici amount pre exist antibodi necessari develop ade sar cov infect howev point view dynam pneumocyt infect two case bodi high concentr preexist antibodi high probabl macrophag infect low concentr antibodi bodi macrophag infect indistinguish conclus could explain lack confirm ade case covid | D000086382;D045473 | T047;T067;T005 |
36,232,663 | challeng futur trend hepatocellular carcinoma immunotherapi hepatocellular carcinoma hcc one common cancer worldwid | D006528;D008113 | T191 |
36,232,662 | spatial structur nanofast apo state complex fluorogen hbr dom nanofast fluorogen activ protein consid one smallest encod fluoresc tag shorten variant anoth fluoresc tag fast nanofast work nice one known fast ligand substanti limit applic protein find reason behavior investig spatial structur dynam nanofast apo state complex fluorogen molecul use solut nmr spectroscopi show truncat fast affect structur remain part protein data suggest delet n terminus fast destabil c termin domain apo state contact fluorogen direct serv free energi reservoir enhanc ligand bind propens protein structur nanofasthbr dom complex reveal atomist detail nanofast interact rhodanin base ligand explain ligand specif nanofast select ligand lowest dissoci constant disubstitut hydroxybenzyldienerhodainin allow non canon intermolecular ch n hydrogen bond provid optim pack ligand within hydrophob caviti protein | D012236 | T109;T130 |
36,232,661 | magnet separ oxoacid boron salt lake brine synergist enhanc boron adsorb glucos function sio graphen adsorpt separ extract low concentr boron salt lake brine great signific magnet separ avoid problem adsorb granul improv usag effici silicon base adsorb attract interest due superior acid alkali resist polyhydroxi graphen enhanc adsorpt boron ion herein differ boron adsorb deriv magnet separ develop character sem tem xps vsm ft ir xrd analysi adsorpt desorpt perform boron adsorb differ composit evalu isotherm kinet paramet boron extract evalu base adsorpt desorpt test graphen base magnet adsorb go fe sio msio glu regist high boron adsorpt capac mgg ph boron solut mgg east taigen salt lake brine na mg ca cl ion littl interfer boron adsorpt adsorb exhibit magnet separ perform good cycl life result show acid alkali desorpt solut littl effect adsorb composit graphen enhanc adsorpt boron ion adsorb develop studi promis recov boron low concentr boron contain salt lake brine | D006108;D014874 | T131;T109;T196 |
36,232,660 | evalu circul microrna adipokin breast cancer survivor arm lymphedema breast cancer relat lymphedema bcrl form secondari lymphedema character abnorm swell one arm due accumul lymph fluid interstiti tissu space result obstruct lymphat vessel due surgeri insult radiotherapi chemotherapi due multifactori natur condit pathogenesi secondari lymphedema remain unclear search molecular factor associ condit ongo studi aim identifi serum microrna adipokin associ bcrl blood collect breast cancer survivor process obtain serum small rna sequenc bcrl vs non bcrl n per group microrna differenti express fold chang gt p lt lymphedema case without lymphedema quantifi valid cohort quantit revers transcript pcr bcrl n non bcrl n leptin adiponectin level measur combin cohort bcrl n non bcrl n use enzym link immunosorb assay two signific upregul microrna mir p mir p strong correl onset lymphedema diabet mellitus bcrl group leptin level higher bcrl cohort compar non bcrl cohort p lt metabol syndrom biomark adiponectinleptin ratio found lower bcrl group non bcrl group median vs p lt extens studi mechan identifi microrna associ leptin arm lymphedema may provid new insight potenti biomark lymphedema follow prospect cohort studi | D001943;D000073116;D000074166;D008209 | T047;T046;T101;T191;T201;T114 |
36,232,659 | transcript respons circadian clock gene artifici light night puls cricket gryllus bimaculatus light major signal entrain circadian clock regul physiolog behavior rhythm organ includ insect artifici light night alan disrupt natur light dark cycl negat impact anim various level simul alan use dim light stimuli test impact gene express cricket gryllus bimaculatus model insect physiolog chronobiolog night adult light dark regim rais cricket expos min light puls lx relat express five circadian clock associ gene compar use qpcr dim alan puls elicit tissu depend differenti express gene strongest effect observ brain optic lobe cricket circadian pacemak express opsin long wave oplw upregul well cryptochrom cri period per find demonstr even dim alan exposur may affect insect molecular level underscor impact alan circadian clock system | D057906;D006135 | T040;T204 |
36,232,658 | genom wide identif character express analysi toll like receptor marbl rockfish sebastiscus marmoratus toll like receptor tlr cluster type transmembran protein play role innat immun base marbl rockfish sebastiscus marmoratus genom databas studi use bioinformat method identifi analyz tlr gene famili member result show tlr gene famili member sebastiscus marmoratus smatlr could divid five differ subfamili number amino acid encod sma tlr gene rang physicochem properti encod protein differ member also comput result protein structur predict phylogenet relat motif analysi show structur function smatlr relat conserv quantit real time pcr qrt pcr analysi reveal express pattern smatlr gill liver spleen head kidney kidney intestin smatlr wide detect test tissu tend express higher immun relat tissu polyriboinosin polyribocytidyl acid poli c challeng smatlr smatlr smatlr smatlr smatlr signific upregul spleen liver result studi help understand status tlr gene famili member marbl rockfish provid basi studi function analysi gene famili | D001492;D010473 | T013 |
36,232,657 | analysi effect vitro photodynam therapi prostat cancer tissu histopatholog examin magnet reson imag prostat cancer signific shorten lifetim patient even diagnos earli stage develop minim invas focal therapi photodynam therapi reduc number neoplast cell spare delic structur extrem advantag treat prostat cancer studi investig effect photodynam therapi perform prostat tissu sampl vitro use quantit magnet reson imag histopatholog analysi prostat tissu sampl treat oxygen solut rose bengal rb protoporphyrin ix disodium salt ppix illumin visibl light analyz chang morpholog microscopi measur spin lattic spin spin relax time tesla treat prostat tissu sampl histopatholog imag reveal chromatin condens swell stroma case thrombot necrosi swell stroma accompani pyknot nuclei occur sever sampl protein fragment stroma magnet reson imag treat prostat tissu sampl reveal differ spin lattic spin spin relax time prior post photodynam action | D010778;D011471 | T191;T061 |
36,232,656 | cellular lactat spectroscopi use tesla clinic apparatus cellular lactat key cellular metabolit marker anaerob glycolysi cellular lactat uptak releas product glucos glycogen interconvers pyruv import determin cellular energi known lactat present spectrum neoplasm low malign without necrot lesion also appear lactat signal associ anaerob glucos mitochondri dysfunct inflammatori respons aim studi detect lactat cell cultur use proton magnet reson h mrs tesla clinic apparatus mr optima character medium field system studi select metabolit togeth cellular lactat identifi use appropri protocol manag algorithm paper describ result obtain cancer cell cultur medium field system proven possibl detect small molecul lactat clinic instrument h mrs perform use clinic mr apparatus use tool clinic analysi | D019344;D009369 | T121;T109;T123;T191 |
36,232,655 | cxcl ccl cmv seroposit new prognost factor sever covid cours exact pathophysiolog sever covid entir elucid establish hyperinflammatori respons cytokin storm play import role aim studi examin cmv status select chemokin complement compon covid concentr given molecul differ time molecular proteom level total covid patient icu non icu patient healthi control enrol studi concentr select chemokin cxcl cxcl ccl ccl ccr complement factor c c cfd cbpa car cr examin mrna protein level regard covid cours icu vs non icu group cmv status differ time interv detect sever signific differ chemokin complement profil icu non icu group pro inflammatori chemokin complement system appear great contribut pathogenesi develop sever covid higher concentr cxcl ccl plasma reduc mrna express presum negat feedback mechan well cmv posit status correl sever cours covid therefor cxcl ccl cmv seroposit consid new prognost factor sever covid cours howev depth research need | D000086382;D003586 | T047;T067 |
36,232,654 | sox differenti regul inherit myogen abil muscl fiber type satellit cell deriv fast slow type muscl adult skelet muscl primarili divid fast slow type muscl distinct capac regener metabol contract satellit cell play import role adult skelet muscl howev under mechan satellit cell myogenesi poor understood previous found sox high express adult fast type muscl therefor aim valid satellit cell myogenesi differ muscl fiber type investig regul sox satellit cell myogenesi first isol satellit cell fast slow type muscl individu found satellit cell deriv differ muscl fiber type generat myotub similar origin type observ cell deriv fast muscl higher effici prolifer lower potenti self renew compar cell deriv slow muscl demonstr sox facilit develop satellit cell deriv myotub toward inher muscl fiber type reveal higher express nfix differenti fast type muscl deriv myogen cell inhibit transcript slow type isoform myhb tnnc bind sox hand sox activ mefc promot slow fiber format slow type muscl deriv myogen cell nfix low express show differ effect sox regul satellit cell develop find demonstr satellit cell myogen progenitor cell tend develop toward fiber type similar origin express sox nfix partial explain development differ myogen cell deriv fast slow type muscl | D018482;D032446 | T023;T024;T025 |
36,232,653 | planta vitro silico studi chiral n benzyladenin deriv discoveri receptor specif enantiom cytokinin anticytokinin activ cytokinin classic phytohormon affect stage plant ontogenesi applic agricultur limit lack appropri ligand includ specif individu cytokinin receptor work seri chiral n benzyladenin deriv studi potenti cytokinin anticytokinin compound contain methyl group carbon atom benzyl moieti make r enantiom four pair chiral nucleobas correspond ribonucleosid contain various substitu c posit adenin heterocycl synthes nucleophil substitut reaction secondari optic activ amin use strong influenc chiral studi compound interact individu cytokinin receptor arabidopsi thaliana uncov vivo vitro assay ahk creahk receptor shown low affin studi nucleobas ahk receptor exhibit signific affin therebi three synthet ahk specif cytokinin discov n methylbenzyl adenin mba fluoro n methylbenzyl adenin fmba chloro n methylbenzyl adenin cmba interact pattern individu receptor specif enantiom ration structur analysi molecular dock two enantiom n methylbenzyl adenosin amino n methylbenzyl adenosin found exhibit receptor specif chiral depend anticytokinin properti | D017360;D029681;D012263 | T116;T002;T114 |
36,232,652 | hydroxyapatit biobas materi treatment diagnosi cancer great advanc cancer treatment undertaken last year consequ develop new antitumor drug abl target cancer cell decreas side effect better understand behavior neoplast cell invas metastasi specif drug deliveri system dds base use hydroxyapatit nanoparticl hap nps gain attent merit comprehens review focus potenti applic deriv intrins properti hap eg biocompat biodegrad togeth easi function easi control poros crystallin morpholog hap nps capac tailor properti dls base hap nps well recogn advantag control drug load releas furthermor function nps allow target uptak tumor cell rapid elimin reticuloendotheli system res avoid advanc hap nps involv use drug nanocarri also employ nanosystem magnet hyperthermia therapi gene deliveri system adjuv cancer immunotherapi nanoparticl cell imag | D053758;D009369 | T191;T073 |
36,232,651 | topic treatment actin keratosi metalloproteinas express clinico patholog retrospect studi actin keratosi intraepitheli prolifer atyp keratinocyt could progress invas squamous cell carcinoma evid suggest import role dermal matrix metalloproteinas progress atyp skin epitheli lesion evalu clinic efficaci three differ therapeut modal medic devic contain piroxicam cream sunscreen photodynam therapi ingenol mebut gel treat suspici actin keratos biopsi histopatholog examin analyz express matrix metalloproteinas immunohistochemistri clinic dermoscop reflect confoc microscopi evalu reveal gradual decreas standard score valid actin keratosi assess end treatment histopatholog point view document substanti restor normal skin architectur immunohistochem evalu matrix metalloproteinas show reduct express treat skin lesion compar baselin actin keratos consid precursor squamous cell carcinoma treatment crucial prevent develop aggress diseas studi monitor evolut actin keratos subject three differ topic therapi valu correl clinic histopatholog find moreov matrix metalloproteinas larg recogn factor involv pathogenesi evolut actin keratosi squamous cell carcinoma demonstr immunohistochemistri reduct express treatment add new valuabl concern field | D002294;D004224;D055623 | T191;T109 |
36,232,650 | dynam assess tissu plasma egfr activ tm mutat droplet digit pcr assay monitor respons resist non small cell lung cancer treat egfr tkis assess tumor egfr mutat status necessari proper manag patient advanc non small cell lung cancer nsclc evalu impact dynam analys plasma tissu egfr mutat use ultra sensit droplet digit pcr ddpcr assay manag nsclc patient treat egfr tyrosin kinas inhibitor egfr tkis pair tumor tissu plasma sampl egfr mutat lung adenocarcinoma patient prior first line egfr tkis treatment baselin diseas progress subject egfr mutat analysi use ddpcr togeth analys clinicopatholog characterist treatment outcom patient egfr activ mutat detect baselin plasma associ bone metastasi p shorter progress free surviv vs month p overal surviv vs month p compar without pre treatment egfr tm mutat found baselin tumor tissu patient signific associ brain metastasi p shorter brain metastasi free surviv p presenc egfr tm mutat baselin tumor tissu correl emerg acquir egfr tm mutat detect progress diseas progress acquir egfr tm mutat detect plasma sampl rebiopsi tissu concord rate dynam monitor tissu plasma egfr mutat status baselin progress use ddpcr clinic impact evalu egfr tkis treatment efficaci patient outcom well emerg resist nsclc | D002289;D008175 | T191 |
36,232,649 | restor mitochondri function essenti endothelium depend vasodil induc acacetin hypertens rat mitochondri dysfunct endothelium contribut progress hypertens play obligatori role modul vascular tone acacetin natur flavonoid compound shown possess multipl benefici effect includ vasodilat howev whether acacetin could improv endotheli function hypertens protect mitochondria depend apoptosi remain determin mean arteri pressur map wistar kyoto wki rat spontan hypertens rat shr administ acacetin intraperiton h intragastr six week examin endotheli injuri evalu immunofluoresc stain transmiss electron microscop tem vascular tension measur perform assess protect effect acacetin mesenter arteri endotheli injuri pathogenesi shr model huvec treat angiotensin ii ang ii mitochondria depend apoptosi open mitochondri permeabl transit pore mptp mitochondri dynam protein determin fluoresc activ cell sort fac immunofluoresc stain western blot acacetin administ intraperiton great reduc map shr mediat pronounc endothelium depend dilat mesenter arteri vascular dilat reduc remark ng nitro l arginin methyl ester l name inhibitor synthesi acacetin administ intragastr six week appar effect map improv endothelium depend dilat shr activ akteno pathway protect abnorm endothelium mitochondria furthermor acacetin remark inhibit ang ii induc apoptosi inhibit increas express cyclophilin cypd promot open mptp ros generat atp loss disturb dynamin relat protein drp optic atrophi opa dynam huvec studi suggest acacetin protect endotheli dysfunct hypertens activ akteno pathway modul mitochondri function target mptp drpopa depend dynam | D047309;D006973;D007022 | T047;T109;T033 |
36,232,648 | loss function rrmf domain osrosa caus steril rice oryza sativa l crop seed product develop anther male fertil main agronom trait key biolog process flower plant activ dna demethyl regul mani plant development process ensur mec dna glycosylas enzym find role osrosa osrosa gene edit mutant generat use crisprca system osrosa mutant shrink spikelet smaller anther pollen grain stain iodin stain show signific reduct total solubl sugar starch content compar wildtyp wt caus complet male steril similar express gene involv pollen anther develop decreas osrosa mutant compar wt furthermor bisulfit sequenc show cg chg methyl ospk gene promot signific increas osrosa mutant caus reduc express ospk osrosa mutant dna methyl tdr gene promot similar wt osrosa mutant indic dna methyl effect osrosa gene specif express srosa mutant chang produc frame shift mutat truncat pem cxxc rrmf domain combin previous studi find suggest rrmf domain osrosa function domain loss rrmf osrosa caus steril rice | D045647;D007246;D007455;D012275 | T046;T116;T002;T121;T126;T123;T196;T168;T033 |
36,232,647 | metal metal oxid nanomateri fight plankton bacteria biofilm review emphas mechanist aspect misus mismanag antibiot made treatment bacteri infect challeng challeng magnifi bacteria form biofilm increas bacteri resist time desir develop anti infect materi antibacteri activ resist drug rapid develop nanotechnolog anti infect strategi base metal metal oxid nanomateri wide use antibacteri antibiofilm treatment review expound state art applic metal metal oxid nanomateri bacteri infect diseas specif attent given antibacteri mechan metal metal oxid nanomateri includ disrupt cell membran damag protein nucleic acid moreov practic antibiofilm mechan employ metal metal oxid nanomateri also introduc base composit biofilm includ extracellular polymer substanc quorum sens bacteria final current challeng futur perspect metal metal oxid nanomateri anti infect field present facilit develop use | D000890;D001424;D049329;D009696 | T047;T073;T121;T123;T114 |
36,232,646 | associ hypomagnesemia liver injuri role gut barrier dysfunct inflamm efficaci abstin week medic manag alcohol use disord patient investig involv serum magnesium level earli alcohol liver diseas ald gut barrier dysfunct inflamm alcohol use disord aud patient last efficaci week abstin medic manag allevi hypomagnesemia forti eight heavi drink aud patient male femal f particip studi patient group serum alanin aminotransferas alt level marker liver injuri group group gr alt ul mf without indic earli stage ald group group gr alt gt ul mf earli stage ald patient sub divid within group patient normal magnesium mmoll defici magnesium less mmoll level particip assess baselin bl receiv standard medic manag week reassess treatment end w femal particip studi show signific lower baselin level magnesium male counterpart gr patient show greater propens necrot type liver cell death report higher chronic recent heavi drink magnesium level improv normal rang gr post treatment especi hypomagnesemia sub group mmoll bl vs mmoll w p gr apoptot km necrot km respons signific independ associ inflammasom activ compris lbp lipopolysaccharid bind protein tnf tumor necrosi factor along serum magnesium aud patient liver injuri week medic manag seem improv magnesium normal level group exhibit inflammatori activ lbp tnf contribut clinic signific hypomagnesemia group level magnesium along uniqu inflammatori activ seem signific predict apoptot necrot type hepatocyt death | D000437;D008108 | T047;T048 |
36,232,645 | interspeci comparison interact energi photosynthet protein rubisco cabp ligand ribulos bisphosph carboxylaseoxygenas rubisco function initi enzym dark reaction photosynthesi catalyz reaction extract co atmospher fix co organ compound rubisco classifi four type isoform iv accord sequenc base phylogenet tree given size comput cost accur quantum chemic calcul function analysi rubisco high howev recent advanc hardwar perform use fragment molecular orbit fmo method enabl ab initio analys rubisco perform fmo calcul multipl structur dataset various complex carboxylarabinitol bisphosph cabp ligand substrat analog investig whether phylogenet relationship base sequenc inform physicochem relev well whether novel inform unobtain sequenc inform reveal extract featur similar phylogenet relationship found sequenc analysi term singular valu decomposit identifi residu strong interact ligand characterist isoform princip compon result identifi strong correl phylogenet relationship obtain sequenc analysi residu interact energi ligand notabl import residu locat far ligand make comparison among speci use residu proxim ligand insuffici | D002245;D012273 | T126;T123;T116;T197 |
36,232,644 | txnip promot human nk cell develop dispens nk cell function abil natur killer nk cell kill tumor cell without prior sensit make rise player immunotherapi increas understand develop function nk cell improv clinic util oppos murin nk cell develop human nk cell develop still less understood studi role thioredoxin interact protein txnip human nk cell differenti stabl txnip knockdown overexpress cord blood hematopoiet stem cell follow vitro nk cell differenti txnip overexpress margin effect indic endogen txnip level suffici process txnip knockdown howev reduc prolifer earli differenti stage great decreas nk cell number transcriptom analysi experiment confirm show reduc protein synthesi upon txnip knockdown like caus low prolifer contrari profound effect earli differenti stage txnip knockdown led limit alter nk cell phenotyp effect nk cell cytotox cytokin product thus txnip promot human nk cell differenti affect protein synthesi prolifer earli nk cell differenti stage redund function nk cell matur | D007694;D013879 | T025;T123;T116 |
36,232,643 | motor behavior deficit cuprizon model valid rotarod test paradigm multipl sclerosi ms neuroinflammatori disord histopatholog character multifoc inflammatori demyelin lesion affect central nervous system white grey matter especi progress phase diseas immunomodulatori treatment strategi lose effect develop novel progress ms treatment option pre clinic anim model indispens among various differ model cuprizon de remyelin model frequent use studi determin tissu damag repair histolog ultrastructur level function readout less common appli among various overt function deficit gait coordin abnorm common observ ms patient motor behavior mediat complex neural network origin cortex termin skelet muscl sever method exist determin gait abnorm small rodent includ rotarod test paradigm review articl provid overview valid characterist rotarod test cuprizon intox mice | D003711;D009103;D000074586 | T043;T047;T046 |
36,232,642 | multipl timescal dynam analysi function impair mutat human ileal bile acid bind protein human ileal bile acid bind protein hi babp key role enterohepat circul bile salt two intern bind site exhibit posit cooper accompani site select glycochol gca glycochenodeoxychol gcda two abund bile salt human improv understand role dynam ligand bind introduc function impair singl residu mutat two key region protein subject mutant nmr relax analysi md simul accord result mutat vicin cd qa gh qa turn result redistribut motion freedom apo hi babp mutat qa deterior site select gca gcda result channel ms fluctuat faster motion bind pocket hamper realize key side chain interact mutat qa abolish posit bind cooper gcda leav ms motion c termin half unchang decoupl dynam cluster n termin half display increas flexibl vicin site md simul variant indic structur differ portal region mutat induc chang dynam depend proton state histidin dynam coupl efgh portal cd region helic cap evidenc highlight interplay structur dynam effect bile salt recognit hi babp | D005999;D006000 | T121;T109;T123;T116 |
36,232,641 | prepar high crystallin silk nanofibril use improv mechan properti silk film due commend biocompat regener silk fibroin rsf film attract consider research interest howev poor mechan properti rsf film limit use various biomed applic studi novel high crystallin silk fibril success extract silk combin degum ultrason ultrason acceler develop silk nanofibril measur nm surfac degum silk fiber confirm via scan electron microscopi addit crystallin index silk fibril found signific higher convent degum silk confirm fourier transform infrar ftir spectroscopi result furthermor break strength elong rsf film increas fold fold respect follow addit silk nanofibril thus mechan properti rsf film remark improv addit silk nanofibril impli use excel reinforc materi rsf film | D005349;D047011 | T121;T123;T116 |
36,232,640 | rb like bacteriophag recogn antigen one altern primari receptor power enterobacteri antigen type provid robust protect direct recognit cell surfac bacteriophag receptor recognit protein rbp recent recogn bacteriophag infect antigen produc strain e coli employ various strategi tackl nonspecif protect even relat phage includ rb like virus often wide host rang consid good candid use phage therapi howev mechan phage overcom antigen barrier remain unknown demonstr rb relat phage cognac whiski direct use certain type antigen primari receptor recogn virus long tail fiber ltf rbp gp antigen becom attract instead obstacl simultan recogn multipl antigen type ltfs phage bind addit receptor ompa protein enabl infect rough strain e coli specul mechan forc deploy short tail fiber stf trigger ltf bind antigen underneath allow receptor bind domain stf break polysaccharid layer | D001435 | T005 |
36,232,639 | melatonin type receptor activ regul blue light exposur induc mous corneal epitheli damag modul impair autophagi apoptosi mt receptor member melatonin receptor belong g protein coupl receptor main regul circadian rhythm sleep brain previous studi shown mani cell tissu hekt cell retina mt receptor involv mitochondri homeostasi antioxid anti inflammatori respons studi aim investig effect blue light bl exposur express melatonin receptor mous cornea evalu function role corneal epitheli damag expos week old cbl mice bl jcm twice day day signific increas express hne mt observ cornea mt antagonist treat mice expos bl show increas express p decreas express bax cleav caspas compar mice expos bl addit mt antagonist treat mice show enhanc mda corneal damag conclus bl exposur induc mt express mous cornea mt activ modul impair autophagi apoptosi increas express bax apoptosi activ therebi regul progress corneal epitheli damag induc bl exposur | D065306;D008550 | T037;T121;T109;T125;T033 |
36,232,638 | unravel mitochondri determin tumor respons radiat therapi radiotherapi repres high target effici treatment choic mani cancer type curat palliat intent nevertheless radioresist consist adapt respons tumor radiat induc damag repres major clinic problem grow bodi literatur suggest mechan relat mitochondri chang metabol remodel might play major role radioresist develop work main contributor acquir cellular radioresist relat mitochondri chang term reactiv oxygen speci hypoxia epigenet alter discuss focus recent find point major role mitochondria respons radiotherapi along implic mechan under radioresist radiosensit briefli summar recent propos mitochondria target strategi overcom radioresist phenotyp cancer | D009369 | T191 |
36,232,637 | enhanc photocatalyt activ anataserutil heterojunct lanthanum tin co dope anataserutil heterojunct prepar use sol gel method modifi lasn singl dope co dope sn dope promot transform anatas rutil la dope inhibit phase transform la sn co dope show inhibitori effect co dope la sn increas visibl light absorpt exhibit synergist effect inhibit recombin photogener electron hole improv photocatalyt activ basi singl element modif first order reaction rate constant lasn co dope sampl min time higher pure tio min meanwhil mechan photodegrad methylen blue mb lasn co dope anataserutil heterojunct discuss electrochem measur free radic trap experi | D007811;D008751 | T121;T109;T196;T130 |
36,232,636 | effect combin pentadecano acid tamoxifen treatment tamoxifen resist mcf sc breast cancer cell estrogen receptor indic breast cancer adapt endocrin therapi tamoxifen defici absenc estrogen receptor er breast cancer cell result reduc efficaci endocrin therapi investig effect combin tamoxifen pentadecano acid therapi er express breast cancer cell drug resist gene express pattern determin rna sequenc analysi vitro experi first time demonstr combin treatment pentadecano acid odd chain fatti acid tamoxifen synergist suppress growth human breast carcinoma mcf stem cell mcf scs found tamoxifen resist show reduc er express compar parent mcf cell addit combin treatment synergist induc apoptosi accumul sub g cell suppress epitheli mesenchym transit emt exposur combin induc express er transcript protein level along suppress critic surviv signal pathway erk mapk egfr mtor collect decreas er express restor pentadecano acid treatment result revers tamoxifen resist overal pentadecano acid exhibit potenti enhanc efficaci endocrin therapi treatment er express breast cancer cell | D001943;D013629 | T191;T109;T121 |
36,232,635 | photosynthet effici glyco metabol chang artifici triploid loquat contribut heterosi manifest previous studi indic extens genet variat could generat due polyploidi consid close associ manifest polyploid heterosi previous studi confirm triploid loquat demonstr signific heterosi ploidi effect under mechan larg unknown studi aim overcom narrow genet distanc loquat increas genet variat level triploid loquat systemat illumin heterosi mechan triploid loquat deriv two cross combin inter simpl sequenc repeat issr simpl sequenc repeat ssrs adopt evalu genet divers transcriptom sequenc rna seq perform investig gene express well pathway chang triploid found extens genet variat produc format triploid loquat polymorph ratio issr ssrs respect almost marker pic valu higher suggest issr ssrs could work well loquat assist breed furthermor result reveal broaden genet distanc parent genet variat triploid could promot addit rna seq result suggest numer gene differenti express triploid parent screen moreov kegg analys reveal photosynthet effici glyco metabol signific chang triploid loquat compar parent consist result physiolog indic analys leaf micro structur observ qrt pcr valid collect result suggest extens genet variat occur triploid chang photosynthet effici well glyco metabol triploid might result heterosi manifest triploid loquat | D031983;D057885 | T047;T168;T002 |
36,232,634 | molecular morpholog characterist de obstruct rat urinari bladder updat mani patient outlet obstruct secondari prostat enlarg lower urinari tract symptom lutss increas frequenc micturit standard treatment transurethr resect prostat turp allevi obstruct symptom howev turp percent patient continu experi lutss aim present studi rat identifi mechan normal remov obstruct could explain persist symptom microarray data control obstruct de obstruct femal rat bladder made possibl studi mrna express also bank electron micrograph similar detrusor microarray signific differ control obstruct bladder mrnas obstruct de obstruct bladder differ signific mrnas control de obstruct bladder differ signific mrnas observ mani mrnas increas obstruct bladder decreas control level de obstruct mani mrnas decreas obstruct bladder increas follow de obstruct mrnas signific higher lower de obstruct bladder control bladder also found ultrastructur detrusor cell obstruct bladder cross section area much larger control control cell smooth outlin similar cross section area de obstruct detrusor cell larger cross section area control well corrug surfac cell area vari suggest shrinkag de obstruct cell even find point contact gap junction plaqu type detrusor cell abund finger like process detrusor cell obstruct de obstruct bladder occasion found control detrusor possibl local gap junction channel de obstruct rat bladder organ properti intermedi control obstruct bladder instead de obstruct bladder gene express morpholog function properti individu cell organ make distinct differ control obstruct bladder | D020728;D001748 | T061;T047 |
36,232,633 | safeguard dna replic golden touch mida mechan dna replic tight regul fundament process allow correct duplic transfer genet inform parent cell progeni involv coordin assembl sever protein protein complex result replic fork licens fire progress howev dna replic pathway strewn hurdl affect replic fork progress phase result cell adapt sever mechan ensur replic complet entri mitosi segreg chromosom minim abnorm review describ possibl obstacl replic fork might encount cell manag protect dna replic next g | D004261 | T045 |
36,232,632 | review modern therapeut option outcom sacubitrilvalsartan heart failur sacubitrilvalsartan sv pharmaceut strategi increas natriuret peptid level inhibit neprilysin regul renin angiotensin aldosteron pathway block receptor data innov medic main base paradigm hf studi includ heart failur reduc eject fraction hfref diagnos patient indic major improv morbid mortal sv administr compar enalapril larg part observ favor result relat signific revers cardiac remodel confirm two prospect trial prove hf evalu hf furthermor accord subgroup analysi paragon hf research sv show benefit hfref mani subject preserv eject fraction hfpef indic decreas hf hospit among left ventricular eject fraction lvef lt review examin proven benefit sv highlight continu research treat individu vari hf characterist articl analys publish data regard safe efficaci sv patient hf includ decreas mortal hospit increas qualiti life revers heart remodel benefit led hf guidelin recommend updat inclus sv combin key compon hfref treatment | D006333 | T047;T046 |
36,232,631 | efficaci renal safeti prophylact tenofovir alafenamid hbv infect cancer patient undergo chemotherapi data compar efficaci safeti prophylact entecavir etv tenofovir disoproxil fumar tdf tenofovir alafenamid taf hbv infect cancer patient undergo chemotherapi studi aim compar efficaci renal safeti etv tdf taf set hbsag posit cancer patient treat etv n tdf n taf n chemotherapi retrospect enrol antivir efficaci risk renal event evalu rate complet viral suppress year etv tdf taf group respect p signific proport patient develop renal dysfunct chemotherapi incid acut kidney injuri aki chronic kidney diseas stage migrat compar among etv tdf taf group taf relat safe patient predispos factor aki includ hypoalbuminemia cisplatin use patient switch tdf taf chemotherapi renal function remain stabl viral suppress well maintain switch conclus taf good renal safeti compar efficaci etv tdf hbv infect cancer patient receiv chemotherapi switch tdf taf chemotherapi safe without loss efficaci | D058186;D009369 | T191;T047;T037 |
36,232,630 | damag dna earli event neurodegener induc pluripot stem cell deriv motoneuron ubqln ph mutat ubiquilin ubqln mutat lead famili amyotroph later sclerosi fal frontotempor dementia ftld unknown mechan combin ipsc technolog crispr mediat genom edit technolog generat ipsc deriv motor neuron ipsc mn model diseas relev mutat result increas opportun diseas mechan research drug screen studi introduc ubqln ph mutat healthi control ipsc line use crisprca differenti mns studi patholog ubqln relat al vitro mn model faith recapitul specif aspect diseas includ mn apoptosi sodium arsenit sa treatment found differ number size ubqln inclus ubqln ph mns wild type wt mns also observ cytoplasm tar dna bind protein tardbp also known tdp aggreg ubqln ph mns wt mns well recruit tdp stress granul sgs upon sa treatment note ubqln ph mutat induc mns dna damag earli event ubqln al addit dna damag led increas compens fus wherea ubqln ph mutat impair function therefor fus may involv dna damag repair signal | D000690;D057026 | T047;T025 |
36,232,629 | trimetazidin anti ischem drug reduc antielectroshock effect certain first generat antiepilept drug trimetazidin tmz anti ischem drug improv cellular metabol most administ patient poor control ischem heart diseas ihd sinc ihd consid frequent causat factor cardiac arrhythmia often coexist seizur disord decid investig effect tmz electroconvuls threshold test ect influenc action four first generat antiepilept drug maxim electroshock test mes mice tmz mgkg affect ect appli dose mgkg decreas antielectroshock action phenobarbit tmz mgkg reduc effect phenytoin administ dose mgkg diminish action carbamazepin reveal interact seem pharmacodynam sinc tmz affect brain level antiepilept drug furthermor combin tmz valproat antiepilept drug signific impair motor coordin evalu use chimney test long term memori assess passiv avoid task affect either tmz combin antiepilept drug obtain result suggest tmz may benefici add therapi patient ihd epilepsi | D004827;D014292 | T121;T047;T109;T033 |
36,232,628 | deep learn predict brca mutat surviv digit h e slide epitheli ovarian cancer brca gene mutat status alreadi determin therapeut algorithm high grade serous ovarian cancer patient nevertheless assess suffici identifi patient genom instabl sinc brca mutat well known mechan homolog recombin defici hr pathway patient display hr behav similar brca mutat patient hrd assess challeng progress overcom brca test prognost inform import drug prescript howev hr test alreadi integr clinic practic quit expens refund mani countri select patient like benefit assess brca wt patient earli stage diagnost process would allow optim genom profil resourc studi sought explor whether somat brca gene status predict use comput patholog standard hematoxylin eosin histolog detail adopt public avail deep learn base weak supervis method use attent base learn automat identifi sub region high diagnost valu accur classifi whole slide clam model also test progress free surviv pfs predict model test cohort train set n test set n ovarian cancer patient somat brca mutat area curv achiev train test set respect model refin manual identifi area interest half case imag use train imag valid model reach zero classif error train set perform term valid roc auc valid accuraci final appli predict pfs model achiev auc negat predict valu posit predict valu base analys plan step develop prove refer classif perform explor hyperparamet space train optim eventu tweak learn algorithm neural network architectur better suit specif task action may allow model improv perform consid outcom | D000077321;D010051 | T191;T066 |
36,232,627 | receptor bind domain sar cov lambda variant better chanc delta variant evad bntb covid mrna vaccin induc humor immun sar cov delta lambda variant name variant concern voc variant interest voi respect world health organ variant two mutat spike receptor bind domain rbd region lr tk mutat delta variant lq fs mutat lambda variant use surfac plasmon reson spr base technolog evalu effect mutat human angiotensin convert enzym ace bamlanivimab bind affin rbd ligand ace delta rbd approxim twice strong wild type rbd increas account increas infect delta variant hand spite amino acid chang lambda rbd similar affin ace wild type rbd protect anti wild type rbd antibodi bamlanivimab bind poor delta rbd lambda rbd nevertheless serum antibodi individu immun bntb vaccin found bind well delta rbd less effici lambda rbd contrast result block abil ace bind serum antibodi decreas lambda delta rbd titer sera bntb mrna vaccin individu drop fold within six month vaccin regardless whether target rbd wild type delta lambda may account partial fall time protect effect vaccin variant | D000086382;D000086402 | T047;T067;T005 |
36,232,626 | cytokin imbal biomark treatment resist schizophrenia treatment resist schizophrenia trs import unresolv problem biolog clinic psychiatri approxim case schizophrenia sch trs may due fact patient trs may suffer pathogenet non dopamin sch develop neuroinflamm suppos play import role purpos narrat review attempt summar data character pattern product pro inflammatori anti inflammatori cytokin develop therapeut resist ap pathogenet prognost signific cytokin imbal trs biomark narrat review demonstr problem evalu contribut pro inflammatori anti inflammatori cytokin maintain chang cytokin balanc becom new key unlock mysteri non dopamin sch develop new therapeut strategi treatment trs psychosi set acut chronic neuroinflamm addit inconsist result previous studi role pro inflammatori anti inflammatori cytokin indic trs biomark like serum level one cytokin cytokin balanc confirm hypothesi cytokin imbal one import trs biomark hypothesi partial support variabl respons immunomodul patient trs prescrib without take account cytokin balanc relat serum level import pro inflammatori anti inflammatori cytokin trs | D014150;D011618;D012559 | T121;T048;T039 |
36,232,625 | model dna damag repair cell respons relat p system expos ioniz radiat repair dna damag induc ioniz radiat play import role cell respons ioniz radiat radiat induc dna damag also activ p system determin fate cell kinet repair affect cell complex dna damag influenc cell respons fate via affect p system mechanist studi influenc cell respons differ let radiat introduc new repair modul p system model nasic mont carlo track structur code factor determin kinet doubl strand break dsb repair model includ chromosom environ complex dsb kinet dsb repair model consid resect depend resect independ compart p system model simul interact among gene protein model cell respons low high let irradi simul respect found kinet dsb repair great affect cell fate later biolog effect larg number dsbs slow repair process lead sever biolog consequ high let radiat induc complex dsbs repair slow process subsequ result longer cycl arrest furthermor apoptosi secret tgf mont carlo track structur simul realist repair modul p system model develop studi expand function nasic code simul mechan radiobiolog effect | D053903;D016159 | T123;T116;T049 |
36,232,624 | structur effect phosphoryl protein arginin methyltransferas bind histon h protein arginin methyltransferas prmt enzym respons arginin methyl various protein includ histon h prmt promis drug target play role pathomechan sever diseas especi progress certain type cancer recent prove phosphoryl prmt residu increas methyltransferas activ furthermor elev level enzym measur case human hepatocellular carcinoma type tumour studi construct complex unmodifi human prmt methylosom protein mep structur phosphoryl variant complex full length histon h peptid full length histon h built situ human prmt mep enzym use experiment h fragment extens molecular dynam simul structur energi analys perform complex apo protein partner well result provid atom level explan two import experiment find increas methyltransferas activ phosphoryl prmt compar unmodifi type prmt methyl free form histon h bound nucleosom atom level complex structur h prmt mep help design new inhibitor uncov structur function relationship prmt enzym | D006657;D009369 | T191;T123;T116 |
36,232,623 | chronic exposur endocrin disruptor vinclozolin lead lung damag via nrf nf kb pathway alter endocrin disrupt substanc ed common pervas environ pose serious risk human anim health endocrin disrupt compound edc associ varieti detriment human health effect includ respiratori issu result abil disrupt cell physiolog vinclozolin rs dichlorophenyl methyl vinyloxazolidin dion common dicarboximid fungicid use treat plant diseas sever studi analyz effect vinclozolin exposur reproduct system less known effect organ lung mice expos day oral administ vinclozolin dose mgkg vinclozolin exposur induc histolog alter collagen deposit lung addit vinclozolin induc inflamm oxid stress led lung apoptosi studi demonstr first time toxicolog effect vinclozolin limit reproduct system also involv organ lung | D052244;D005659 | T131;T039 |
36,232,622 | new rout glycosyl porphyrin via aromat nucleophil substitut n ar synthesi cellular uptak studi glycoporphyrin group compound high valu purpos photodynam therapi biomed applic despit great progress field new divers orient synthes carbohydr porphyrin hybrid increas desir herein present effici mild metal free condit synthesi glycoporphyrin versatil natur n ar procedur present exampl preliminari biolog studi conduct cytotox cellular uptak final molecul | D010778;D011166 | T061;T109;T123 |
36,232,621 | knock five lysyl oxidas famili gene enabl identif lysyl oxidas pro enzym regul gene five lysyl oxidas gene share similar enzymat activ contribut tumor progress knock five lysyl oxidas gene mda mb breast cancer cell use crisprca order identifi gene regul lox lysyl oxidas order studi gene mechanist detail futur express full length cdna encod lox identifi four gene whose express downregul knock cell rescu follow lox express express lysyl oxidas agr stox dnajb dnajc gene agr stox previous identifi promot tumor progress addit identifi sever gene downregul knock cell strong upregul follow lox loxl express derl gene also promot tumor progress littl proteolyt process express lox pro enzym mda mb cell hek cell lox pro enzym effici cleav introduc point mutat known bmp adamt cleavag site lox bmp mutant secret cleav lox doubl mutant dmutlox cleav secret howev even presenc irrevers lox inhibitor aminoproprionitril bapn point mutat lox variant induc express gene suggest lox pro enzym hitherto unrecogn biolog function | D000629;D009369 | T191;T109;T130 |
36,232,620 | improv thermost catalyt effici phospholipas moritella sp jt disulfid bond engin strategi mine phospholipas pld high activ stabil attract strong interest investig novel pld marin moritella sp jt mspld biochem structur character previous studi howev short half life time optimum reaction temperatur serious hamper applic herein disulfid bond engin strategi appli improv thermost compar wild type mspld mutant sc tcdc ac addit two disulfid bond exhibit fold c c increas melt temperatur tm unexpect specif activ catalyt effici kcat km also increas respect enhanc activ might attribut increas activ entropi displac water molecul transit state result molecular dynam simul md reveal introduct doubl disulfid bond rigidifi global structur mutant might caus enhanc thermost final synthesi capac mutant synthes phosphatid acid pa evalu convers rate pa reach h reaction wild type mspld reach h mutant sc tcdc ac signific reduc time need reaction reach equilibrium present result pave way applic mspld food pharmaceut industri | D034221;D010739 | T007;T126;T116 |
36,232,619 | genom wide identif function character reveal pivot role bnaaatgf salt stress toler nitrogen limit adapt allotetraploid rapese autophagi common physiolog process organ includ higher plant atg subfamili core member autophagi relat gene atg famili play key role plant growth develop nutrient stress respons howev core atg homolog role stress resist remain elus allotetraploid rapese aacc brassica napus l studi identifi atg subgroup member consist three phylogenet clade base analysi genom annot conserv motif differenti transcript respons bnaatg salt stress nitrogen limit nutrient stress investig identifi bnaaatgf core atg member gene co express network analysi decreas bnaaatgf express repress salt toler transgen rapese plant signific reduc root na retent salt stress moreov downregul bnaaatgf increas nitrogen n limit sensit transgen rapese plant decreas n uptak transloc enhanc n remobil nitrogen starvat summari identifi core atg homolog character physiolog molecular mechan under salt stress toler nitrogen limit adapt result may provid elit genet resourc genet improv nutrient stress toler rapese | D029688;D029741 | T168;T002 |
36,232,618 | aspirin resist vascular diseas review highlight critic need improv point care test person therapi aspirin resist describ phenomenon patient receiv aspirin therapi respond favor treatment categor continu incid advers cardiovascular event andor lack reduc platelet reactiv studi demonstr one four patient vascular diseas resist aspirin therapi place almost four fold increas risk major advers limb advers cardiovascular event despit increas cardiovascular risk incur aspirin resist patient strategi diagnos overcom resist yet clinic valid integr current five uniqu laboratori assay shown promis aspirin resist test light transmiss aggregometri platelet function analyz thromboelastographi verifi platelet work newer antiplatelet therapi plavix ticagrelor test altern overcom aspirin resist use combin aspirin alon proven superior aspirin alon recent breakthrough discoveri demonstr rivaroxaban anticoagul function inhibit activ factor x taken combin aspirin improv outcom patient vascular diseas current studi determin new regim may benefit consid aspirin resist | D010975;D014652 | T121;T047 |
36,232,617 | carvedilol select stimul arrestin depend sercaa activ cardiomyocyt augment contractil heart failur hf carri highest mortal western world blocker adrenerg receptor ar antagonist part cornerston pharmacotherapi post myocardi infarct mi chronic hf cardiac ar activ arrestin g protein coupl receptor gpcr adapt protein promot sarco endo plasmic reticulum ca atpas serca sumo small ubiquitin like modifi ylation activ therebi direct increas cardiac contractil given certain blocker carvedilol metoprolol activ arrestin andor sercaa heart investig effect two agent cardiac arrestin depend sercaa sumoyl activ found carvedilol metoprolol acut induc arrestin interact sercaa hc cardiomyocyt neonat rat ventricular myocyt nrvms result enhanc sercaa sumoyl howev translat enhanc sercaa activ presenc ar select invers agonist ici ici indic oppos effect carvedilol occupi ar subtyp carvedilol occupi ar stimul arrestin depend sercaa activ addit amplitud fraction shorten nrvms transfect overexpress arrestin acut enhanc carvedilol presenc ici contrast metoprolol without effect nrvms shorten amplitud irrespect ici co treatment import pro contractil effect carvedilol also observ human induc pluripot stem cell hipsc deriv cardiac myocyt cms overexpress arrestin fact present even without concomit ici treatment human cms metoprolol without concomit ici affect contractil human cms either conclus carvedilol metoprolol stimul arrestin mediat sercaa sumoyl activ ar cardiac myocyt translat direct posit inotropi howev uniqu arrestin depend pro contractil effect carvedilol may oppos mask carvedilol bound ar subtyp signal | D006333;D057026 | T047;T046;T025 |
36,232,616 | connect aortic stiff vascular contract sex matter studi design connect aortic stiff vascular contract young male femal wistar rat hypothes femal anim display reduc intrins media layer stiff associ improv vascular function atom forc microscopi afm base nanoindent analysi use deriv stiff young modulus biaxial ie longitudin circumferenti unload aortic ring reactiv studi compat uniaxi load ie circumferenti use assess vascular respons select adrenerg receptor agonist presenc absenc extracellular calcium elastin collagen level indirect evalu fluoresc microscopi picrosirius red stain kit respect report male femal wistar rat display similar afm deriv aortic media layer stiff even though femal anim withstand higher aortic intima media thick diamet ratio male femal anim also present reduc phenylephrin induc aortic forc develop concentr respons time forc curv specif observ impair forc displac part contract curv aphas aton experi conduct without extracellular calcium addit collagen level lower femal anim without signific elastin content fragment chang summari sex relat function differ isol aorta appear relat dissimilar dynam vascular reactiv extracellular matrix composit rather direct respons shift intrins media layer stiff | D004549;D059289 | T047;T046;T123;T116 |
36,232,615 | pyrolysi kinet combust behavior high nitrogen compound azobi triazol studi thermal decomposit behavior azobi triazol atrz non isotherm thermal decomposit kinet atrz studi use thermogravimetr differenti scan calorimetri tg dsc method tg dsc atrz analyz heat rate kmin argon atmospher thermal decomposit kinet paramet peak temperatur tp appar activ energi e pre exponenti factor lg atrz calcul use kissing ozawa satava sestak method ea lg calcul use kissing ozawa satava sestak method close kjmol kjmol kjmol respect use combin three method reaction mechan function g atrz obtain result show decomposit temperatur atrz c decomposit rapid exotherm pyrolysi path atrz investig pyrolysi gas chromatographi mass spectrometri py gcms experi atrz three differ decomposit path final generat n hc n ch nc n hcn cn laser ignit combust durat atrz peak temperatur c laser ignit combust durat atrzcl peak temperatur c rapid energi releas rate atrz promot combust energi releas cl | D009584;D000077319 | T070;T123;T196 |
36,232,614 | novel strategi cancer dexibuprofen load nanostructur lipid carrier aim work design innov nanostructur lipid carrier nlcs deliveri dexibuprofen dxi antiprolif therapi tumor process overcom side effect dxi nlc sampl prepar beeswax miglyol tween use high pressur homogen two level factori design appli optim formul physicochem properti particl size zeta potenti polydispers index entrap effici measur optim paramet dxi nlcs exhibit mean particl size nm polydispers index high dxi entrap effici higher moreov dxi nlcs provid prolong drug releas slower free dxi dxi nlcs stabl month morpholog reveal possess spheric shape vitro cytotox anticanc potenti studi perform toward prostat pc breast mda mb cancer cell line highest activ dxi nlcs observ toward breast cancer cell effect inhibit therefor dxi nlcs constitut promis antiprolif therapi proven especi effect breast cancer | D001943;D049329 | T191;T073 |
36,232,613 | track extracellular vesicl biodistribut new method approach extracellular vesicl ev nanos lipid bilay vesicl releas almost cell type rang diamet nm sever micrometr abil carri biolog activ molecul protein lipid rna dna ev natur vector play import role mani physiolog patholog process amount composit ev human biolog fluid serv biomark use diagnos diseas monitor effect treatment ev promis use therapeut agent natur vector drug deliveri howev success use ev clinic practic requir understand biodistribut organ numer studi conduct far biodistribut ev show intraven administr ev most local organ rich blood vessel organ associ reticuloendotheli system liver lung spleen kidney order improv resolut new dye label develop detect method optim work review avail modern method approach use assess biodistribut ev well discuss advantag limit | D000067128;D008051 | T026 |
36,232,612 | medicin herb deriv ingredi protect cognit declin vivo model alzheim diseas alzheim diseas ad patholog hallmark includ amyloid beta plaqu format current approv singl target drug effect amelior ad medicin herb deriv ingredi mhdis multitarget multichannel properti engend except ad treatment outcom review delin vivo model mhdis suppress deposit downregul secretas activ inhibit oxid stress enhanc antioxid activ reduc lipid peroxid prevent tau hyperphosphoryl upregul protein phosphatas express downregul glycogen synthas kinas express reduc inflammatori mediat part upregul brain deriv neurotroph factorextracellular signal regul protein kinas mediat signal downregul p mitogen activ protein kinas p mapk c jun n termin kinas jnk mediat signal attenu synapt dysfunct increas presynapt protein postsynapt protein acetylcholin level prevent acetylcholinesteras activ protect neuron apoptosi main upregul aktcycl amp respons element bind proteinb cell lymphoma bcl mediat anti apoptot signal downregul p mapkjnkbcl associ x protein bax caspas baxapoptosi induc factor cebp homolog proteinglucos regul protein autophagi mediat apoptot signal therefor mhdis list review protect induc cognit declin inhibit accumul oxid stress tau hyperphosphoryl inflamm synapt damag neuron apoptosi cortex hippocampus earli late ad phase | D000544;D060825;D010946 | T047;T002;T048 |
36,232,611 | target rapamycin regul photosynthesi cell growth auxenochlorella pyrenoidosa auxenochlorella pyrenoidosa effici photosynthet microalga autotroph growth reproduct advantag rich nutrit high protein content target rapamycin tor conserv protein kinas eukaryot structur function littl known tor signal auxenochlorella pyrenoidosa found conserv aptor protein auxenochlorella pyrenoidosa key compon tor complex torc present compon rictor sin torc absent auxenochlorella pyrenoidosa drug sensit experi show azd could effect inhibit growth auxenochlorella pyrenoidosa wherea rapamycin torin ku obvious effect growth auxenochlorella pyrenoidosa transcriptom data result indic auxenochlorella pyrenoidosa tor aptor regul various intracellular metabol signal pathway auxenochlorella pyrenoidosa gene relat chloroplast develop photosynthesi signific regul aptor inhibit azd addit aptor involv regul protein synthesi catabol multipl metabol pathway auxenochlorella pyrenoidosa import inhibit aptor azd disrupt normal carbon nitrogen metabol protein fatti acid metabol tca cycl auxenochlorella pyrenoidosa cell thus inhibit growth auxenochlorella pyrenoidosa rna seq result indic aptor play import role photosynthesi intracellular metabol cell growth provid insight function aptor auxenochlorella pyrenoidosa | D010788;D020123 | T195;T121;T109;T070;T044;T039 |
36,232,610 | protein acetyl go viral implic antivir immun viral infect viral infect host viral protein undergo post translat modif ptms includ phosphoryl ubiquitin methyl acetyl play critic role viral replic pathogenesi host antivir respons protein acetyl one import ptms catalyz seri acetyltransferas divert acetyl group acetyl molecul specif amino acid residu substrat affect chromatin structur transcript signal transduct therebi particip cell cycl well metabol cellular process acetyl host viral protein emerg role process virus adsorpt invas synthesi assembl releas well host antivir respons method studi protein acetyl gradual optim recent decad provid new opportun investig acetyl viral infect review summar classif protein acetyl standard method use map modif emphasi viral host protein acetyl viral infect | D000998;D014777 | T121;T047 |
36,232,609 | glutathion transferas ptgstf improv biomass product salt toler regul xylem cell prolifer ion homeostasi reactiv oxygen speci scaveng poplar glutathion transferas gsts play essenti role plant cell detoxif secondari metabol howev accur function growth respons abiot stress woodi plant still larg unknown work phi class glutathion transferas encod gene ptgstf isol poplar p trichocarpa biolog function regul biomass product salt toler investig transgen poplar ptgstf ubiquit express various tissu organ predomin express leav induc express salt stress transgen poplar overexpress ptgstf show improv shoot growth wood format improv salt toler consist increas xylem cell number size normal condit optim na k homeostasi strengthen reactiv oxygen speci scaveng salt stress transcriptom analys demonstr express gene relat hydrolas cell wall modif ion homeostasi ros scaveng regul transgen plant find impli ptgstf improv biomass product salt toler regul hydrolas activ cell wall modif ion homeostasi ros scaveng transgen poplar consid use gene candid genet breed new tree varieti improv growth salt stress condit | D032107;D055049 | T040;T002 |
36,232,608 | coronavirus diseas associ thrombot microangiopathi literatur review coronavirus diseas covid lead clinic signific multisystem disord also affect kidney accord recent data renal injuri form thrombot microangiopathi tma nativ kidney rank third frequenc review global literatur reveal case tma associ covid among identifi case patient present thrombot thrombocytopen purpura ttp case present atyp hemolyt urem syndrom ahus altogeth seven patient ahus previous proven pathogen like pathogen genet complement abnorm tma occur time viremia even viral clearanc infect covid result almost mild respiratori symptom major patient digest symptom occur almost one third patient regard clinic present covid associ tma case show major deviat known present patient ttp treat plasma exchang fresh frozen plasma corticosteroid rituximab caplacizumab furthermor patient ahus underw plasma exchang without steroid initi therapi patient receiv c complement inhibitor mortal studi cohort patient ttp patient ahus exact role covid set covid associ tma remain unclear covid like repres second hit ahus ttp manifest genet predispos individu earli identif tma subtyp appropri prompt specif treatment could lead good outcom compar surviv recoveri statist tma caus | D065766;D000086382;D011697;D057049 | T047;T067 |
36,232,607 | structur basi bind alloster activ leucin adp mammalian glutam dehydrogenas glutam dehydrogenas gdh play key role metabol glutam import compound cross road carbon nitrogen metabol relev neurotransmitt despit one first discov alloster enzym gdh still pose challeng structur character alloster site structur adp low resolut avail mammalian gdh complex alloster activ aim deciph structur basi gdh alloster activ use bovin gdh model first time report mammalian gdh structur ternari complex activ leucin adp co crystal potassium ion resolv improv angstrom resolut gdh complex adp also present ternari complex leucin adp differ binari complex adp conform gdh c terminus involv leucin bind subunit interact potassium site identifi work may mediat interact leucin adp bind site data provid novel insight mechan gdh activ leucin adp link enzym regul de acetyl | D005969;D018698 | T121;T126;T116;T123 |
36,232,606 | dysregul mirisc regulatori network promot hepatocellular carcinoma target pikakt signal pathway hepatocellular carcinoma hcc remain third lead malign worldwid caus high mortal adult children neuropatholog associ gene aeg function scaffold protein correct assembl rna induc silenc complex risc optim increas activ overexpress oncogen mirna period degrad target tumor suppressor gene oncogen mir play semin role carcinogenesi hcc henc exact molecular biolog function oncogen cluster mir aeg axi yet examin wide hcc explor express mir aeg targetassoci gene qrt pcr western blot addit role mir aeg axi studi hcc flow cytometri analysi express level aeg chang mir mimic mir transfect hcc cell hand decreas mir express aeg sirna transfect hcc cell mir aeg axi silenc induc apoptosi gm phase arrest inhibit cellular prolifer angiogenesi upregul p p rb pten downregul lsf lca bcl opn mmp pik akt hcc cell | D006528;D008113;D035683 | T191;T123;T114 |
36,232,605 | novel strategi identifi nsclc microrna biomark mechan analysi base brand new cerna hub ffl network find reliabl mirna marker reveal potenti mechan play import role diagnosi treatment nsclc exist comput method identifi mirna biomark consid express variat mirna reli heavili train set defici lead high fals posit rate independ regulatori model import complement tradit model co regul impervi dataset addit previous studi mirna mechan develop non small cell lung cancer nsclc most focus post transcript level distinguish nsclc subtyp problem improv main two area mirna identif base nog network biolog function mirna target gene construct node direct competit regulatori network illustr mechan nsclc classifi lung adenocarcinoma luad lung squamous cell carcinoma lusc work one mirna biomark luad mir p four lusc mir p mir p mir p mir p obtain valid use literatur extern dataset cerna hub ffl involv transcript factor tfs microrna mirna mrnas long non code rnas lncrnas construct multipl interact among compon within net transcript post transcript protein level new regul reveal network meanwhil network reveal reason previous conflict conclus role cd actb itgb nsclc demonstr necess type studi nsclc novel mirna marker screen method node direct competit cerna hub ffl network construct work provid new idea screen tumor marker understand tumor develop mechan depth | D002289;D002294;D008175;D035683;D062085 | T191;T123;T114 |
36,232,604 | pike modul mitochondri metabol increas sdha express mediat statfto axi previous studi shown phosphoinositid kinas enhanc activ akt pike involv regul sever biolog process cancer previous studi demonstr crucial function pike cancer energi metabol regul pentos phosphat pathway ppp flux howev whether pike regul energi metabol affect mitochondri chang poor understood present studi show pike promot mitochondri membran potenti lead increas prolifer glioblastoma cell mechanist pike affect express respiratori chain complex succin dehydrogenas sdha mediat regul axi statfto taken togeth result reveal inhibit pike reduc statftosdha express lead suppress mitochondri function thus find suggest pike astatftosdha axi promis anti cancer treatment target | D005909;D051057 | T191;T126;T116 |
36,232,603 | nutrient mediat percept signal human metabol perspect nutrigenom interact select nutrient link gene involv specif organ reveal genet make individu respons particular nutrient interact gene food open opportun addit bioactiv compound specif popul compris ident genotyp slight differ genet blueprint human advantag determin effect nutrient metabol bodi basic knowledg emerg nutrigenom nutrigenet appli optim health prevent treatment diseas addit nutrient mediat pathway detect cellular concentr nutrient sugar amino acid lipid metabolit integr coordin organism level via hormon signal review deal interact nutrient various aspect nutrigenet nutrigenom along pathway involv nutrient sens regul provid detail understand new lead edg nutrit research potenti applic dietet practic | D004032;D054647 | T091;T168 |
36,232,602 | impact non nodul diazotroph bacteria agricultur understand molecular mechan benefit crop agricultur face increas challeng regard achiev sustain growth product without negat impact environ use bioinocul emerg sustain solut agricultur especi bioinocul base diazotroph bacteria brazil forefront studi intend identifi benefici diazotroph bacteria well molecular character associ bacteri plant side highlight main advanc molecular studi understand benefit brought plant diazotroph bacteria differ molecular pathway plant regul genet epigenet provid better plant perform among discuss involv gene relat nitrogen metabol cell wall format antioxid metabol regul phytohormon coordin plant respons environment factor anoth import aspect regard plant recogn microorgan benefici better understand plant bacteria environ interact assist futur formul effici bioinocul could turn contribut sustain agricultur practic | D000975;D010937 | T116;T121;T039;T123;T044;T125 |
36,232,601 | develop evalu implement hous made target next generat sequenc spoligotyp french laboratori epidemiolog studi investig transmiss chain tuberculosi undertaken worldwid tackl spread crispr locus divers call spoligotyp wide use genotyp assay mycobacterium tuberculosi complex mtbc character herein develop hous made target next generat sequenc tngs spoligotyp compar output membran base spoligotyp total clinic mtbc strain retrospect select repres local epidemiolog data analysi train set allow set presenc absenc threshold spacer maxim sensibl specif relat membran base spoligotyp threshold spacer consid present read per million spacer spacer spacer confirm threshold perform use valid set overal agreement train valid set respect discrep concern six strain two spacer two spacer two spacer tngs spoligotyp whose threshold fine tune care bioinformat pipelin develop process appear techniqu reliabl inexpens free handl error automat automat transfer laboratori comput system | D009169;D014376 | T007;T047 |
36,232,600 | genom mutat stat transcript factor associ human cancer immun diseas signal transduc activ transcript stat key transcript factor regul various biolog process mammalian develop aberr regul stat also causal link mani diseas includ cancer immun relat diseas although persist activ stat due dysregul signal cascad report associ progress solid tumor leukemia various genom mutat stat also found caus wide rang diseas present review comprehens summar result recent studi evalu intrins function stat link stat mutat human diseas review also describ type diseas model use investig mechan under stat driven diseas progress find provid basic knowledg understand regulatori mechan stat progress various diseas result aberr regul stat moreov review may provid insight need creat optim diseas model reflect human diseas associ stat mutat design gene therapi correct stat mutat | D007154;D009369 | T191;T047 |
36,232,599 | structur insight bind propens human ship sh oncogen caga isoform helicobact pylori ship multi domain inositol phosphatas bind varieti phosphotyrosin py contain protein sh domain regul various cell signal pathway modul phosphatidylinositol level plasma membran unfavor helicobact pylori hijack ship caga protein induc gastric cell carcinogenesi date interact ship caga analyz structur point view bind ship sh tyr phosphoryl peptid four epiya motif abcd caga studi use nmr spectroscopi result show epiya c bind similar interfac ship sh includ py bind pocket hydrophob pocket achiev high affin epiya b bind smaller interfac ship sh weak affin summar interfac affin ship sh caga epiya abcd c met fcgrb itim propos potenti ship sh select prefer l gt gt v aliphat residu py posit ligand studi reveal rule ligand sequenc bound ship sh mechan caga protein hijack ship help design peptid inhibitor ship sh | D016480 | T007 |
36,232,598 | profil influenc gene variant relat folat mediat one carbon metabol outcom vitro fertil ivf donor oocyt recipi receiv folic acid fortif nutrit status gene polymorph one carbon metabol confer well known interact pregnant women may affect embryo viabil health newborn folat metabol direct impact nucleotid synthesi methyl increas interest reproduct medicin field studi assess genet influenc folat metabol ivf treatment current perform women use oocyt patient seek child undergo ivf treatment advis prevent intak folat suppli restor known metabol imbal treatment could lead promot specif enzym specif women depend genet varianc present studi assess influenc candid gene variant relat folat metabol serin hydroxymethyltransferas shmt rs rs betain homocystein methyltransferas bhmt rs methionin synthas reductas mtrr rs methylenetetrahydrofol reductas mthfr rs rs methionin synthas mtr rs atp bind cassett subfamili b member abcb rs folat receptor alpha folr rs success ivf treatment perform women recipi donat oocyt implic gene variant seem direct impact pregnanc consecut ivf howev sever gene variant could influenc pregnanc loss event pregnanc mainten consequ folic acid fortif | D013766;D042965 | T126;T116 |
36,232,597 | modul atp product influenc inorgan polyphosph level non athlet platelet rest state platelet produc inorgan polyphosph polyp upon activ stimul blood coagul research link polyp metabol atp product although metabol linkag yet elucid found evid possibl previous studi profession athlet versus non athlet propos regulatori mechan might differ two group explor aspect investig effect modul atp product polyp level blood sampl obtain japanes healthi non athlet presenc acid citrat dextros platelet plasma treat oligomycin rotenon glutamax modul atp product polyp level quantifi fluorometr visual use diamidino phenylindol correl polyp atp nadh calcul contrari hypothesi inhibitor atp product increas polyp level wherea amino acid supplement produc opposit effect general howev polyp level posit correl atp level negat correl nadh level sinc platelet metabol activ exhibit high level atp turnov rate therefor find suggest atp may involv polyp product rest platelet non athlet | D011122;D012402 | T109;T131;T197 |
36,232,596 | chronic exposur vinclozolin induc fibrosi mitochondri dysfunct oxid stress apoptosi mice kidney vinclozolin one use fungicid control fungi fruit veget ornament plant effect exposur differ organ describ inform regard relev vinclozolin induc nephrotox larg miss studi focus potenti mechan vinclozolin induc nephrotox cd male mice administ vinclozolin mgkg oral gavag day vinclozolin administr decreas bodi weight treatment period end experi increas ratio kidney weight bodi weight increas serum urea nitrogen creatinin content vinclozolin also induc histopatholog alter includ tubular dilat necrosi impair integr renal tubular architectur kidney fibrosi analys conduct show vinclozolin administr alter mrna level mitochondri function relat protein sirt sirt pgc tfam nrf vdac cyt c oxid stress increas lipid peroxid decreas total antioxid capac catalas superoxid dismutas activ glutathion level glutathion peroxidas activ kidney furthermor vinclozolin induc toxic alter nrf signal relat protein ho nqo vinclozolin administr also affect extrins intrins apoptot pathway upregul express proapoptot factor bax caspas fasl downregul antiapoptot factor bcl level studi suggest vinclozolin induc nephrotox disrupt transcript mitochondri function relat factor nrf signal pathway extrins intrins apoptot pathway | D005659;D056566 | T126;T131;T116 |
36,232,595 | bind alpha crystallin cortic nuclear len lipid membran deriv singl len sever studi report crystallin concentr eye len cytoplasm decreas correspond increas membran bound crystallin age cataract influenc lipid cholesterol composit differ cortic membran cm nuclear membran nm crystallin bind membran still unclear studi use electron paramagnet reson epr spin label method investig crystallin bind bovin cm nm deriv total lipid extract singl len compar cms nms higher percentag membran surfac occupi crystallin bind affin correl less mobil order surfac nms crystallin bind cm nm decreas mobil signific chang order hydrophob surfac membran result suggest crystallin main bind surfac bovin cm nm surfac bind crystallin membran clear young lens may play benefici role membran stabil howev decreas cholesterol content within cm mimic decreas cholesterol content cataract len membran crystallin bind increas hydrophob membran surfac indic crystallin bind form hydrophob barrier passag polar molecul support barrier hypothesi develop cataract | D002386;D007908;D038201 | T047;T023;T116;T123;T190;T033 |
36,232,594 | klotho promot develop intrauterin adhes via pikakt signal pathway intrauterin adhes iua refer injuri basal layer endometrium caus various factor often accompani clinic symptom abnorm menstruat infertil recurr abort period abdomin pain recent year number studi report effect klotho klb occurr develop human tumor fibrot diseas relationship endometri fibroblast endometri fibrosi elucid studi compar express klb endometri stromal cell esc patient iua normal control construct anim cell model iua conduct express verif function experi klb found express klb signific increas esc iua patient rat model compar control overexpress klb could promot prolifer fibrosi esc addit overexpress klb activ pikakt signal pathway esc studi show klb protein high express esc patient iua enhanc stromal cell prolifer cell fibrosi activ pikakt pathway thus promot develop iua | D019869;D014591 | T047;T126;T116 |
36,232,593 | target signal pathway downstream rig imav cns stimul product endogen type ifn suppress eae type interferon ifn includ ifn play protect role multipl sclerosi ms anim model experiment autoimmun encephalomyel eae type ifn induc stimul innat signal includ via cytoplasm rig like receptor present studi investig potenti effect chimer protein contain key domain rig signal product cns endogen ifn ask whether would exert therapeut effect eae intrathec administ adeno associ virus vector aav encod fusion protein compris rig card domain c first amino acid mitochondri antivir signal protein mav aav cm vivo imag ifnluciferas report mice reveal singl intrathec inject aav cm result dose depend sustain ifn express within cns ifn express signific increas day immunofluoresc stain ifn yfp report mice reveal extraparenchym cd cell choroid plexus astrocyt sourc ifn moreov intrathec administr aav cm onset eae induc suppress eae ifn depend find suggest access signal pathway downstream rig repres promis therapeut strategi inflammatori cns diseas ms | D004681;D007370 | T121;T050;T116;T129 |
36,232,592 | role demyelin persist neurolog mental impair covid long term neurolog mental complic covid call post covid syndrom long covid affect qualiti life persist manifest long covid includ fatigu anosmiahyposmia insomnia depressionanxieti memoryattent deficit physiolog basi neurolog psychiatr disord still poor understood review summar current knowledg neurolog sequela post covid patient discuss brain demyelin possibl mechan complic focus neuroimag find numer review experiment theoret studi consid brain demyelin one mechan central neural system impair sever factor might caus demyelin inflamm direct effect virus oligodendrocyt cerebrovascular disord induc myelin damag contradict solid fundament basi under demyelin mechan neurolog injuri relat littl publish clinic evid relat demyelin covid patient reason probabl lie fact clinic studi use convent mri techniqu detect larg clear visibl demyelin lesion limit number studi use specif method myelin quantif detect chang white matter tract month acut phase covid futur research appli quantit mri assess myelin combin neurolog psycholog studi help understand mechan post covid complic associ demyelin | D001289;D000086382;D003711 | T047;T046;T067;T048 |
36,232,591 | dynam structur properti comb long chain branch polym shear flow use hybrid multi particl collis dynam mpcd molecular dynam md method investig effect arm shear flow dynam structur properti comb long chain branch lcb polym dens arm first analyz dynam properti lcb polym track tempor chang end end distanc backbon arm well orient backbon flow gradient plane simultan rotat tumbl behavior stabl frequenc observ word lcb polym undergo process period stretch fold stretch state transit rotat whose period obtain fit tempor chang orient period function addit impact induc random fast motion arm backbon descend shear rate increas analyz period rotat behavior lcb polym find arm function keep lcb polym motion stabl meanwhil find rotat period lcb polym main determin conform distribut non shrinkabl state structur along veloc gradient direct second structur properti numer character averag gyrat tensor lcb polym chang gyrat accord lcb polym roll vari shear rate analyz align lcb polym compar linear star counterpart find lcb polym long arm like correspond linear chain high speed reach configur expans limit flow direct howev comb polym shorter arm stronger resist configur expans impos flow field moreov increas arm length comb polym shear flow follow chang linear polym like capsul like behavior | D056004;D011108 | T104;T044;T066;T122 |
36,232,590 | stimul macrophag systemat administr gm csf acceler adult wound heal process skin wound repair remain major challeng clinic care various strategi employ improv repair process recent report macrophag import regener various tissu organ howev influenc wound repair unclear aim explor whether macrophag would particip wound heal process explor new possibl treatment skin defect first creat mous full thick skin defect model observ distribut macrophag regener tissu detect influenc macrophag skin defect repair macrophag deplet macrophag mobil model found number macrophag increas signific skin defect persist process wound repair regener process signific prolong macrophag deplet anim rt qpcr elisa assay demonstr express growth factor perturb regener tissu activ macrophag granulocyt macrophag coloni stimul factor gm csf inject could signific improv wound heal accompani upregul express various growth factor conclus current studi demonstr macrophag critic skin regener gm csf exhibit therapeut potenti wound heal | D016178;D014945 | T040;T116;T129 |
36,232,589 | enhanc effect cyano group c xn hydrogen halogen bond complex x cyanomethan trimethyl amin ch n cn n xnme n x h cl br paper densiti function theori wave function theori calcul carri investig strength natur intermolecular c xn bond interact function number cyano group cn x bond donor maintain x bond acceptor fix specif complex x cyanomethan trimethyl amin ch n cn n xnme n x h cl br use model system geometr paramet vibrat c x stretch frequenc well interact energi use relev indic gaug hydrogen halogen bond strength complex addit characterist interact link complex ie hydrogen halogen bond calcul use follow theoret tool atom molecul aim approach natur bond orbit nbo method energi decomposit analysi eda result show specifi x center strength c xn interact increas signific non addit fashion number cn group moreov natur noncoval part coval interact reveal via aim approach | D006219;D006859 | T196 |
36,232,588 | role exosom chronic rhinosinus systemat review pathophysiolog chronic rhinosinus crs multifactori entir clear object review examin current state knowledg concern role exosom crs systemat review search pubmedmedlin scopus central web scienc databas studi publish august origin research articl describ studi publish english includ review book chapter case studi confer paper opinion exclud qualiti evid assess modifi offic health assess translat ohat risk bias rate tool human anim studi record identifi elig low moder risk overal bias present find indic exosom biomark includ protein microrna act promis biomark diagnost prognosi crs patient addit may contribut find novel therapeut target exosom reflect tissu proteom excel high avail materi studi proteom alter noninvas first step alreadi taken advanc research nasal exosom need might open wider door individu medicin crs | D055354;D035683;D012220;D012852 | T026;T123;T047;T114 |
36,232,587 | metal organ framework meet metal oxid carbon fiber synergist effect enhanc photodegrad antibiot pollut photodegrad show potenti strategi allevi excess antibiot crisi synergist effect various metal compound immobil conduct substrat consid wastewat treatment howev develop facil univers approach ration design enhanc photocatalyt properti endur extrem challeng herein develop strategi facilit photocatalyt reaction design composit architectur zif ligand bind situ synthesi zno seed layer carbon fiber architectur dissolut releas seed layer excess methylimidazol methanol solut use binder enhanc interplay organ ligand substrat evalu system antibiot contamin photodegrad tetracyclin hydrochlorid perform remov effici tc mgl ph g photocatalyst illumin within min moreov photocatalyst exhibit steadi photocatalyt activ five cycl present work demonstr strategi enhanc photocatalyt perform carbon fiber accord provid use percept design synergist structur | D004785;D000073396;D015034 | T121;T109;T131;T197 |
36,232,586 | balanc forc field ffcmap improv dynam conform sampl phosphoryl site phosphoryl play key role plant biolog accumul plant cell form observ proteom statist analysi found mani phosphoryl site locat disord region howev current forc field main train structur protein might capac perfect captur dynam conform phosphoryl protein therefor evalu perform ffcmap balanc forc field structur disord protein sampl phosphoryl protein test result differ phosphoryl system includ dipeptid disord protein fold protein complex indic ffcmap forc field better sampl conform phosphoryl site disord protein disord region ff solvent model result strong suggest ffcmap forc field tippd water model best combin conform sampl addit test charmmm fb forc field two phosphoryl system suggest overal perform ffcmap similar fb better charmmm result help research choos suitabl forc field solvent model investig dynam properti phosphoryl protein | D064267 | T123;T116 |
36,232,585 | proteom profil skin mucus european eel anguilla anguilla infect anguillid herpesvirus anguillid herpesvirus anghv import viral pathogen affect eel studi design investig potenti molecular mechan immun respons elicit protein level skin mucus anghv infect anguilla anguilla tandem mass tag tmt label proteom liquid chromatographi tandem mass spectrometri lc msms use perform quantit identif protein addit quantit protein amount detect parallel reaction monitor prm analysi total protein identifi quantifi protein fold chang greater less indic differenti express protein dep overal regul protein regul protein detect dep enrich cam pathway intestin immun pathway herp simplex virus infect pathway phagosom pathway p signal pathway result dep detect prm high consist result tmt label quantit proteom analysi find studi provid import research basi understand pathogenesi anghv | D000811;D005393 | T047;T013 |
36,232,584 | carbon base electrocatalyst design phytic acid versatil biomass deriv modifi function materi increas energi demand exacerb energi shortag highlight urgenc research renew energi technolog carbon materi employ advanc electrod catalyst increas access effici econom energi convers storag solut base electrocatalysi particular carbon materi deriv biomass promis candid replac precious metal base catalyst owe low cost anti corros properti electrochem durabl sustain catalyt applic ration design engin function carbon materi term structur morpholog heteroatom dope crucial phytic acid deriv natur abund renew resourc repres versatil carbon precursor modifi introduc tune aforement properti review discuss synthet strategi prepar function carbon materi use phytic acid explor influenc precursor result materi physicochem characterist also summar recent strategi appli improv oxygen reduct perform porous carbon materi use phytic acid therebi offer guidanc futur design function sustain carbon materi enhanc catalyt properti | D002244;D010833 | T121;T109;T196;T127;T130 |
36,232,583 | role essenti amino acid age induc bone loss age induc osteoporosi global problem essenti amino acid eaa work energi sourc molecular pathway modul bone function systemat review age bone studi aim discuss contribut eaa age bone vitro vivo human investig age peopl osteoporosi serum eaa detect chang without well establish conclus suppli eaa age peopl either rescu affect bone miner densiti bmd bone volum signal studi eaa proven increas bone mass lysin threonin methionin tryptophan isoleucin increas osteoblast prolifer activ differenti decreas osteoclast activ oxid l tryptophan promot bone marrow stem cell bmscs differenti osteoblast howev oxid product tryptophan call kynurenin increas osteoclast activ enhanc differenti adipocyt bmscs taken togeth term bone miner volum view consid eaa posit effect age bone function eaa bone metabol fulli demonstr studi need area futur | D010024;D014364 | T047;T046;T116;T121;T109;T123 |
36,232,582 | downregul mir b p facilit chondrocyt hypertrophi apoptosi via target runx steroid induc osteonecrosi femor head wide use steroid hormon medicin glucocorticoid potenti caus steroid induc osteonecrosi femor head sonfh due mass long term use non code rna hypothesi posit may contribut destruct dysfunct cartilag possibl etiolog sonfh mir b p identifi regulatori factor cartilag degener caus methylprednisolon mps exposur studi cell transfect luciferas report assay confirm mir b p downregul runt relat transcript factor runx mediat mir b p nobli increas express matrix metallopeptidas mmp type x collagen cola runx downstream gene contribut hypertroph differenti chondrocyt effici upregul level matrix metallopeptidas mmp may trigger chondrocyt apoptosi mps treatment cell transfect experi reveal mir b p inhibit chondrocyt hypertrophi suppress mps induc apoptosi result find show mir b p modul runx mmp mmp cola express therebi mediat chondrocyt hypertroph differenti apoptosi sonfh process find reveal mechanist relationship non code rna sonfh provid comprehens understand sonfh bone diseas | D035683;D010020 | T047;T046;T123;T114 |
36,232,581 | microbiom hidraden suppurativa know head recent interest microbiom cutan diseas increas tremend particular interest gut brain skin axi propos stoke pillsburi microbiom suggest pathogenesi hidraden suppurativa howev link commens host yet establish across studi increas abund porphyromona peptoniphilus prevotella spp loss skin commens speci cutibacterium hs lesion consist find role gut blood microbiom hidraden suppurativa fulli elucid accord studi main link intestin base increas risk develop crohn diseas ulcer coliti howev research high need area lifestyl dietari approach probiot seem influenc microbiom henc promis modal adjuv therapi aim review present latest report field research skin blood gut microbiom term hidraden suppurativa | D003424;D000069196;D017497;D064307 | T047;T007;T028;T001;T032 |
36,232,580 | structur characterist polysaccharid gpa gardenia jasminoid immunomodulatori effect macrophag elucid structur characterist polysaccharid isol gardenia jasminoid elli label gpa immunomodulatori activ gpa acid polysaccharid molecular weight kda most compris galacturon acid methyl analysi reveal gal p major sugar residu gpa nuclear magnet reson analysi indic main chain compris gal p ome gal p gal p ome l rha p galactan arabinan link c posit l rha p residu branch chain furthermor gpa show obvious toxic macrophag raw enhanc cell viabil dose time depend manner compar untreat cell nitric oxid product secret cytokin tumor necrosi factor interferon interleukin il il granulocyt macrophag coloni stimul factor gpa treat cell signific increas h gml gpa concentr signific differ cytokin level gpa lipopolysaccharid treat cell posit control summari gpa pectic polysaccharid homogalacturonan rhamnogalacturonan structur region main chain base immunomodulatori effect vitro gpa may potenti use function food medicin | D032062 | T002 |
36,232,579 | proteom transcriptom mutat function assay reveal involv thf plp site gmshmt resist soybean cyst nematod serin hydroxymethyltransferas shmt ec involv interconvers serineglycin tetrahydrofol thf methylen thf play key role one carbon metabol de novo purin pathway cellular methyl reaction redox homeostasi mainten methionin thymidyl synthesi gmshmt soybean gene under soybean cyst nematod scn resist rhg locus gmshmt protein contain four tetrahydrofol thf cofactor bind site l l f n six pyridox phosphat plp cofactor bindingcatalysi site g g h sa h current studi proteom analysi data set protein complex immunoprecipit use gmshmt antibodi scn infect soybean root reveal presenc enrich pathway main use glycineserin substrat glyoxyl cycl redox homeostasi glycolysi heme biosynthesi root leaf transcriptom analysi differenti express gene scn infect support proteom data point direct involv interconvers reaction carri serin hydroxymethyltransferas enzym direct site mutagenesi reveal mutat thf plp site gmshmt result increas scn resist shown involv plp site scn resist special effect two plp site drastic test thf site unpreced find help us identifi biolog outcom thf plp residu gmshmt understand scn resist mechan | D003560;D009348 | T190;T204 |
36,232,578 | combin cell worm approach search compound counteract toxic tau oligom vivo clear relationship tau assembl toxic still establish correl tau conform proteotox effect vivo develop innov cell worm base approach hek cell express tau pl tetracyclin induc system hek rex employ produc differ tau assembl whose proteotox potenti evalu use c elegan lysat cell induc five day signific reduc worm locomotor activ toxic effect relat total amount tau produc cell phosphoryl state relat format multimer tau assembl particular tetramer one investig applic approach test compound act oligomer tau toxic use doxycyclin doxi prototyp drug doxi affect tau solubl promot disassembl alreadi form toxic aggreg lysat cell induc five day effect translat dose depend protect action c elegan find confirm valid combin hek rex cell c elegan base approach platform pharmacolog screen | D024801 | T047 |
36,232,577 | qtl map palmit acid content use specif locus amplifi fragment sequenc slaf seq genotyp soybean glycin max l soybean essenti crop suppli protein oil composit content soybean fatti acid relev human health signific relationship soybean oil process applic identifi quantit trait locus qtl gene relat palmit acid could facilit develop rang nutrit soybean cultivar use molecular marker assist select studi use cultivar higher palmit acid content dongnong lower palmit acid content cultivar hobbit establish f recombin inbr line high densiti genet map contain slaf marker construct distribut across soybean chromosom genet map contain total genet distanc cm averag genet distanc cm adjac marker two qtls relat palmit acid content map use inclus composit interv map explain phenotyp varianc three differ year environ includ qtl includ seed palmit valid develop ssr marker base snpindel signific differenti express analys dongnong hobbit two gene glymag glymag select candid gene high densiti genet map qtls molecular marker help map base clone palmit acid content gene could use acceler breed high nutrit valu cultivar via molecular marker assist breed | D013024;D013025 | T121;T168 |
36,232,576 | character antimicrobi resist clinic relev bacteria isol humananimalenviron interfac use whole genom sequenc austria antimicrobi resist amr public health issu attribut misus antibiot human veterinari medicin sinc amr surveil requir one health approach sampl nine interconnect compart hydrolog open air lab hoal austria obtain six bacteri speci includ prioriti list antibiot resist bacteria arb whole genom sequenc base type includ core genom multilocus sequenc type cgmlst genet phenotyp character amr perform isol eighti nine clinic relev bacteria obtain eight compart includ e coli e faecali k pneumonia e faecium cluster isol speci obtain differ sampl collect date detect isol resist least one antimicrobi e coli e faecali isol differ compart acquir antimicrobi resist gene arg associ veterinari drug aminoglycosid tetracyclin carri conjug mobiliz plasmid three multidrug resist mdr e coli isol found sampl field drainag wastewat earli detect arg arb natur farm relat environ identifi hotspot amr help prevent emerg dissemin along foodfe chain | D000900;D019155 | T121;T195 |
36,232,575 | remodel liver plasma lipidom mice lack cyclophilin recent year sever studi aim investig metabol effect non function absent cyclophilin cypd crucial regulatori compon mitochondri permeabl transit pore report lack cypd affect glucos lipid metabol howev find controversi regard metabol pathway involv report describ effect high fat diet metabol perform lipidom analysi plasma liver sampl cypd wild type wt mice reveal lipid specif alter result absenc cypd cypd mice compar wt anim found signific chang measur lipid speci liver plasma sampl respect higher total lipid content detect tissu accompani abdomin fat accumul assess nuclear magnet reson imag also document characterist chang lipid composit liver plasma result cypd ablat relat increas polyunsatur membran lipid speci addit observ remark differ lipid distribut hepatocyt use histochemistri found characterist chang hepatocyt ultrastructur cypd anim use electron microscopi result highlight possibl long term effect cypd inhibit novel therapeut consider various diseas | D000081362;D033681 | T116;T091;T123;T109 |
36,232,574 | organoid new chapter sarcoma diagnosi treatment sarcoma malign tumor mesenchym origin occur age rariti tumor combin vast number histolog subtyp render studi sarcoma challeng organoid repres complex three dimension cell cultur system deriv stem cell preserv capac differenti cell type tissu origin aim present review studi current status patient deriv organoid well potenti model tumorigenesi perform drug screen sarcoma order identifi relev studi literatur review conduct abl identifi studi publish current manuscript repres first comprehens review literatur focus use organoid diseas model drug sensit test divers sarcoma subtyp | D012509;D012983 | T191 |
36,232,573 | bmal regul prostat growth via cell cycl modul circadian clock system exist organ regul divers physiolog process includ growth use prostat specif bmal knockout mous model pbmal ko pbsncre bmalfxfx immort human prostat cell rwpe wpmi elucid role peripher prostat clock prostat growth bmal ko result signific decreas ventral dorsolater lobe less ki posit epitheli cell control next cap analysi gene express reveal gene associ cell cycl differenti express pbmal ko prostat cdkna code p diurnal express control mous prostat rhythm disturb pbmal ko meanwhil knockdown bmal epitheli rwpe stromal wpmi cell line decreas prolifer furthermor rwpe bmal knockdown increas gg phase cell number reduc phase number find indic core clock gene bmal involv prostat growth via modul cell cycl provid rational research link pathogenesi benign prostat hyperplasia cancer circadian clock | D056930;D057906 | T040;T123;T116 |
36,232,572 | provir alv ltr sequenc essenti continu prolifer alv transform b cell line avian leukosi virus alv induc b cell lymphoma malign chicken insert activ oncogen c myc activ common identifi alv induc tumor use alv transform b lymphoma deriv hp cell line appli situ crispr cas edit integr provir long termin repeat ltr examin effect gene express cell prolifer target delet ltr result signific reduct express number ltr regul gene includ c myc ltr delet also induc apoptosi hp cell affect prolifer demonstr signific ltr mediat regul critic gene compar global effect express function multipl gene ltr delet cell delet c myc major effect hp cell prolifer phenotyp similar ltr delet demonstr signific c myc express alv induc lymphomagenesi overal studi shown potenti target edit ltr global inhibit retrovirus induc transform also provid insight role ltr regul gene alv induc neoplast transform | D001354 | T005 |
36,232,571 | precis medicin approach metabolom artifici intellig recent technolog innov field mass spectrometri support use metabolom analysi precis medicin growth allow also applic algorithm data analysi includ multivari machin learn method fundament manag larg number variabl sampl present review report discuss applic artifici intellig ai strategi metabolom data analysi particular focus wide use non linear machin learn classifi ann random forest support vector machin svm algorithm discuss recent studi research focus diseas classif biomark identif earli diagnosi present challeng implement metabolom ai system limit thereof recent tool also discuss | D001185;D057285 | T073;T061;T066;T090;T091 |
36,232,570 | discoveri cryptic site sar cov papain like proteas analysi druggabl late new coronavirus cov caus outbreak dead respiratori diseas result covid pandem view ongo pandem immedi need find drug treat patient sar cov papain like cystein proteas plpro play import role pathogenesi virus also target protein develop inhibitor drug therefor develop target inhibitor necessari analys verifi plpro site explor whether cryptic bind pocket better activ studi first detect site whole plpro protein sitemap schrdinger version caviti ligbuild v deepsit rough judg possibl activ bind site area use mix solvent dynam simul mixmd probe molecul induc conform chang protein find possibl cryptic activ site final trapp method use predict druggabl cryptic pocket analys chang physicochem properti residu around site work help promot research sar cov plpro inhibitor | D000086382;D010206 | T047;T116;T121;T126;T067 |
36,232,569 | antibiofilm properti antisept agent use pseudomona aeruginosa isol diabet foot ulcer diabet foot ulcer dfus biofilm format major challeng promot wound chronic delay heal antisept propos combat biofilm manag dfus howev limit evid activ agent biofilm question agent best effici evalu antibiofilm activ sodium hypochlorit polyvinylpyrrolidoneiodin pvpi polyhexamethylenebiguanid phmb octenidin pseudomona aeruginosa strain use static dynam system chronic wound like medium cwm mimic chronic wound environ use antibiofilmogram technolog assess abil antisept reduc initi phase biofilm format observ signific activ antisept biofilm format p aeruginosa dilut moreov dilut differ antisept reduc matur biofilm form h log although higher concentr need cwm final bioflux tm model biofilm debrid sodium hypochlorit phmb effect antisept conclus studi show among four antisept test sodium hypochlorit demonstr best antibiofilm activ p aeruginosa biofilm repres altern manag dfus | D000891;D003920;D017719 | T121;T047 |
36,232,568 | resist thyroid hormon case seri studi aim studi describ clinic featur two unrel patient resist thyroid hormon rth first total thyroidectom patient second pregnant woman report featur found newborn also show rth patient year old man total thyroidectomi manag excess thyroid stimul hormon tsh product poor respond replac therapi found thr cg gt p gluli heterozyg mutat also present member famili son brother father interest patient hypertens dyslipidemia hepat steatosi recent suggest rth relat comorbid patient year old pregnant woman multinodular goiter thr heterozyg variant cg gt c best knowledg report literatur newborn tachycardia increas thyroid hormon level show mutat deliveri high parathyroid hormon pth calcium serum level found patient scintigraphi show presenc adenoma parathyroid gland case seri studi provid practic exampl manag rth thyroidectom patient pregnant woman newborn novel rth pathogen mutat describ second time literatur furthermor import metabol assess patient rth highlight possibl correl rth primari hyperparathyroid discuss | D037042;D018382 | T047;T116;T192 |
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