PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,220,862 | jscsncp lma method predict associ lncrna mirna non code rnas ncrnas long consid white eleph genom lack abil encod protein howev recent year biolog experi clinic report prove ncrnas account larg proport organ time play decis role biolog process gene express cell growth develop recent found short sequenc non code rna mirna long sequenc non code rna lncrna regul play import role various complex human diseas paper use new method jscsncp lma predict lncrna mirna unknown associ method combin jaccard similar algorithm self tune spectral cluster similar algorithm cosin similar algorithm known lncrna mirna associ network use consist project complet final predict result show auc valu jscsncp lma fivefold cross valid fivefold cv leav one cross valid loocv respect compar model success prove superior good extens meanwhil model also use three differ lncrna mirna dataset fivefold cv experi obtain good result auc valu respect therefor jscsncp lma help predict associ lncrna mirna | D035683;D062085 | T123;T114 |
36,220,861 | transcript profil felin mammari carcinoma deriv cell line reveal biomark drug target associ metabol cell cycl pathway molecular heterogen felin mammari carcinoma fmcs repres prognost therapeut challeng rna seq base compar transcriptom profil serv identifi recurr exclus differenti express gene deg across sampl type molecular subtyp use mass parallel rna seq identifi deg perform compar function base analysi across tumour four basal like tripl negat tn eight normal like tn three lumin b fher negat lb fher two cell line cl tiho tiho isol primari tumour lb fher two cat includ studi healthi mammari tissu control deg tumour predomin upregul dysregul cls transcriptom extens includ most downregul gene cell cycl metabol relat deg upregul tumour cls includ therapeut target cell cycl regul eg ccnb ccnb cdk cdk gtse mcm mcm metabol relat gene eg fad slca heat shock protein eg hsph hspb hspa gene control centrosom disjunct eg racgap nek collagen molecul eg cola deg specif upregul basal like tn tumour involv antigen process present normal like tn tumour encod g protein coupl receptor gpcrs lb fher tumour associ lysosom phagosom endosom format downregul deg cls associ structur signal cell surfac compon henc result suggest upregul gene enhanc prolifer metabol common featur among fmcs deriv cls contrast dissimilar observ dysregul membran compon highlight cls disconnect tumour microenviron furthermor recurr exclus deg associ dysregul pathway might use develop prognost therapeut relev target panel | D002277;D020869 | T191;T059;T063 |
36,220,859 | spatial stress urban land expans water environ yangtz river delta china high urban industri area demand construct land expand impact water environ take yangtz river delta yrd consid chemic oxygen demand cod ammonia nitrogen nh n characterist pollut studi investig spatial tempor characterist water pollut emiss counti level optim spatial lag model slm estim spatial interact urban expans water pollut emiss direct indirect effect result show water pollut emiss yrd decreas signific high emiss pattern chang contigu scatter distribut emiss cod nh n counti various distanc yangtz river coastlin show logarithm curv relationship associ urban expans water pollut emiss signific stabl everi increas scale urban expans result increas local cod nh n emiss respect emiss adjac counti synchron increas respect result show break associ spatial interact urban expans water pollut emiss allevi environment stress yrd addit delimit urban expans boundari strict restrain scale expans improv region environment carri capac urban water pollut treatment facil pipe network construct urgent need | D000393;D004785;D014873 | T131 |
36,220,856 | toward absolut light pollut indic grow concern negat impact artifici light night biodivers human health increas need defin general indic could use character light pollut well perform spatial tempor comparison paper show tradit indic base direct numer measur sky bright suffer signific limit due calibr bias lack reproduc furthermor measur often perform period clear sky reflect wide varieti meteorolog condit produc high inhomogen level light pollut given site overcom issu propos statist indic call nsb dispers ratio indic deriv statist signific number individu night sky bright measur various meteorolog condit independ absolut photomet calibr requir time precis correct contribut natur light sourc galact plane | D000090465 | T069 |
36,220,853 | ovarian tumor diagnosi use deep convolut neural network denois convolut autoencod discrimin ovarian tumor necessari proper treatment studi develop convolut neural network model convolut autoencod cnn cae classifi ovarian tumor total ultrasound imag ovari known patholog diagnos pre process augment deep learn analysi design cnn cae model remov unnecessari inform eg calip annot ultrasound imag classifi ovari five class use fivefold cross valid evalu perform cnn cae model term accuraci sensit specif area receiv oper characterist curv auc gradient weight class activ map grad cam appli visual verifi cnn cae model result qualit classifi normal versus ovarian tumor cnn cae model show accuraci sensit auc densenet cnn architectur distinguish malign ovarian tumor cnn cae model show accuraci sensit auc densenet cnn architectur grad cam show cnn cae model recogn valid textur morpholog featur ultrasound imag classifi ovarian tumor featur cnn cae feasibl diagnost tool capabl robust classifi ovarian tumor elimin mark ultrasound imag cnn cae demonstr import applic valu clinic condit | D016571;D010051 | T191;T170 |
36,220,850 | spatial tempor distribut etiolog characterist hand foot mouth diseas eva vaccin kunm china vaccin enterovirus ev preval hand foot mouth diseas hfmd remain high spatial tempor distribut enterovirus chang therefor essenti defin tempor featur spatial distribut epidemiolog etiolog characterist hfmd kunm total children diagnos hfmd kunm includ children enterovirus posit clinic sampl demograph geograph epidemiolog etiolog data case acquir analyz enterovirus replac ev incid ev decreas dramat wherea coxsackievirus cv coxsackievirus cv substanti outbreak respect major minor peak extend month compar vaccin ev vaccin cv predomin serotyp show singl peak although high incid hfmd observ guandu chenggong xishan annual incid differ enterovirus serotyp differ differ region enterovirus preval shilin cv cv preval luquan shilin respect cv preval jin cv coxsackievirus cv preval luquan shilin respect meanwhil epidem cycl cv cv year cv enterovirus potenti risk pathogen spatial tempor distribut hfmd vari differ scale incid hfmd associ differ pathogen obvious region differ season trend therefor research multival combin vaccin urgent need proper prevent protect measur could effect control incid hfmd like diseas | D004770;D029821;D004769;D005536;D006232 | T047;T005 |
36,220,848 | prepar applic nanostructur carbon oil fli ash growth promot improv agricultur crop differ dose applic carbon nanomateri cnms agricultur product piqu interest research howev despit enorm import cnms plant develop littl known effect carbon nanoparticl cnp dose plant physiolog respons therefor aim current studi check effect nanostructur carbon deriv oil fli ash cofa deriv first time high energi ball mill follow sonic process phaseolus vulgari l cicer arietinum l plant evalu plant physiolog biochem paramet cofa treat seedl two differ dose mg l mg l cofa control studi result indic germin rate shoot length root length pod length leaf area fresh weight dri weight increas addit cofa likewis cofa increas content chlorophyl pigment chla chlb carotenoid protein carbohydr speci compar control final find show cofa treatment mg l ball mill sonic water bmw constitut best dose growth physiolog find reveal novel strategi cofa engin led boost growth phaseolus vulgari cicer arietinum result high potenti agricultur research provid impact food secur | D029863;D049329;D027805 | T168;T073;T002 |
36,220,847 | efficaci three differ budesonid treatment chines preschool children recurr wheez explor compar clinic control three atom inhal budesonid bud regimen chines preschool children recurr wheez use test respiratori asthma control track score total preschool children posit modifi asthma predict index mapi random assign daili group initi given inhal bud mg day assess everi week symptom well control week dose reduc previous dose afin dose mg day maintain week intermitt high dose group mg twice daili day start earli predefin respiratori tract ill intermitt medium dose group mg twice daili soon contact allergen experienc nasal congest runni nose cough suspici respiratori symptom continu symptom reduc risk factor absent day week treatment track questionnair administ everi week track score symptom consid control averag track score three group treatment signific higher treatment p te number system glucocorticoid cours urgent care visit wheez wheez episod treatment signific differ within three group p clinic treatment children one three treatment option select accord specif situat case mapi posit recurr wheez children | D001249;D019819 | T121;T047;T109 |
36,220,846 | chang plasma fatti acid profil hyperketonem ewe earli lactat preliminari studi transit late pregnanc earli lactat character mark chang energi balanc dairi rumin mobil adipos tissu led increas plasma non esterifi fatti acid nefa hydroxybutyr bhb aim studi analyz total plasma fatti acid healthi hyperketonem dairi ewe earli lactat gas chromatographi gc evalu metabol alter observ studi use cross section experiment design forti six sarda dairi ewe enrol immedi post partum day milk divid two group accord serum bhb concentr non hyperketonem group n bhb mmoll hyperketonem group n bhb mmoll two way anova includ effect group pariti use evalu differ fatti acid fa concentr total plasma fa assess use gc fa show signific differ group tend signific nefa concentr stearic acid influenc pariti result may suggest possibl link lipid metabol inflammatori immun respons hyperketonem group conclus gc repres use tool studi hyperketonemia primipar dairi ewe might show greater risk develop condit | D005227;D005230 | T109;T123;T168 |
36,220,845 | choroid hemodynam central serous chorioretinopathi half dose photodynam therapi effect smoke retrospect studi aim evalu choroid hemodynam half dose photodynam therapi pdt central serous chorioretinopathi csc effect smoke use laser speckl flowgraphi studi includ eye patient treat half dose pdt csc follow least month mean blur rate mbr pdt irradi area whole area pachyvessel pv area non pv npv area fill delay fd area assess baselin month post pdt respect mbr also assess smoke status mbr signific decreas baselin whole pv npv fd area time point p patient never smoker past smoker current smoker baselin signific differ found mbr whole pv npv fd area among never past current smoker mbr chang show signific smaller decreas current smoker never smoker whole p pv p npv p area fd area p half dose pdt csc reduc choroid blood flow pdt irradi area blunt current smoke status | D056833;D010778 | T061;T047 |
36,220,844 | design novel integr microfluid chip continu separ circul tumor cell peripher blood cell cancer one foremost caus death global late stage present inaccess diagnosi treatment common challeng develop countri detect enumer circul tumor cell ctc earli possibl report lead effect treatment isol ctc earli stage challeng due low probabl presenc peripher blood studi propos novel two stage label free rapid continu ctc separ devic base hydrodynam inerti focus dielectrophoret separ domin differenti wall induc inerti lift forc dean drag forc insid curv microfluid channel result size base separ red blood cell rbc platelet size ctc leukocyt numer model use investig mechan hydrodynam inerti focus curvilinear microchannel simul done rbcs platelet ctcs leukocyt four major subtyp select optim valu paramet propos design first stage focus behavior microscal cell studi sort leukocyt ctcs rbcs platelet viabl ctcs separ leukocyt base inher electr properti use dielectrophoresi second stage propos design devic evalu ctc separ effici use numer simul studi consid influenc critic factor like aspect ratio dielectrophoret forc channel size flow rate separ effici shape cell separ result show propos devic yield viabl ctc isol effici throughput mlh | D046210;D009360 | T059;T025;T191 |
36,220,843 | multi angl meta analysi gut microbiom autism spectrum disord step toward understand patient subgroup observ studi shown composit human gut microbiom children diagnos autism spectrum disord asd differ signific neurotyp nt counterpart thus far report asd specif microbiom signatur inconsist uncov reproduc signatur compil public avail raw amplicon metagenom sequenc dataset alongsid new data generat intern cohort largest asd cohort date unifi standard pre process method conduct comprehens meta analysi taxa variabl detect across multipl studi screen metadata test associ microbiom variabl multipl patient subset across multipl dataset determin differenti abund taxa asd versus nt children depend upon age sex bowel function thus mark variabl potenti confound case control asd studi sever taxa includ strain bacteroid stercori clostridium boltea speci granulicatella elegan massilioclostridium coli exhibit differenti abund asd compar nt children subject bowel dysfunct remov adjust age sex bowel function result ad remov signific differenti abund taxa asd diagnos individu emphas import collect control metadata perform largest n comprehens systemat analysi asd gut microbiom data date studi demonstr import account confound variabl design statist compar analys asd nt associ gut bacteri profil mitig confound identifi robust microbi signatur across cohort signifi import account factor compar analys asd nt associ gut profil studi advanc understand differ patient group deliv appropri therapeut identifi microbiom trait german specif asd phenotyp | D000067877;D000069196;D064307 | T007;T028;T001;T048;T032 |
36,220,842 | biolog invas select filter drive behavior diverg biolog invas multi stage process ie transport introduct establish spread stage potenti act select filter trait associ invas success behavior eg explor activ bold play key role facilit speci introduct whether invas act select filter trait well known capit well character introduct invas lizard lampropholi delicata across three independ lineag throughout pacif show invas shift behavior trait mean reduc among individu variat two key predict select filter hypothesi moreov lizard three invas rang also behavior plastic ie greater within individu variat nativ rang counterpart provid support import select filter behavior trait widespread invas given invas speci lead driver global biodivers loss understand invas select specif behavior critic improv predict effect alien speci invad communiti | D058865;D008116 | T098;T014 |
36,220,841 | pollin biolog trait ecolog interact mediat impact mosquito target malathion applic mosquito adulticid perceiv public detriment nontarget arthropod contribut declin nativ benefici insect howev actual impact adulticid nontarget arthropod natur need incorpor biolog ecolog element investig effect biologicalbehavior trait butterfli roost differ height roost site underneath foliag bumblebe hive usag interact parasit predat pollin butterfli bumblebe could mediat impact malathion applic manipul semi field experi florida usa roost height spray rout signific negat relationship mortal butterfli treat ulv malathion high surviv highest roost height butterfli roost among veget higher surviv bumblebe hive access signific higher surviv bumblebe without hive access host plant treat ulv malathion signific reduc parasit monarch egg trichogramma platneri increas predat monarch caterpillar polist paper wasp data provid insight realist impact adulticid applic pollin natur enabl mosquito control district better limit nontarget effect adulticid treatment may help address concern relat potenti nontarget effect | D002080;D007306;D014863 | T131;T204 |
36,220,840 | work memori updat individu bipolar unipolar depress fmri studi understand neurobiolog characterist cognit dysfunct distinct psychiatr disord remain challeng secondari data analysi examin neurobiolog differ brain respons work memori updat among individu bipolar disord bd unipolar depress ud healthi control hc individu year age bd n ud n hc n scan use fmri perform back easi back difficult task letter stimuli happi fear neutral face distractor n back group distractor ancova examin reaction time rt accuraci brain activ task hc show accur faster respons individu bd ud difficulti relat activ prefront posterior pariet paracingul cortic striatal later occipit precuneus thalam region differ among group individu bd show signific lower difficulti relat activ differ left later occipit right paracingul cortic ud individu bd greater difficulti relat worsen accuraci associ smaller activ chang right precuneus greater difficulti relat slow rt associ smaller activ chang prefront frontal opercular paracingul posterior pariet later occipit cortic measur current depress mania correl difficulti relat brain activ differ either group find suggest alter work memori circuitri may trait characterist reduc work memori capac mood disord aberr pattern activ left later occipit paracingul cortic may specif bd | D001714;D003866 | T048 |
36,220,839 | evalu composit antimicrobi activ essenti oil four speci lamiacea martinov nativ iran studi essenti oil obtain four differ plant speci belong lamiacea famili extract mean hydrodistil composit antimicrobi activ evalu compon identifi use gas chromatographi mass spectrometri gc ms among thymol oleic acid caryophyllen oxid pinen cineol palmit acid spathulenol germacren abund speci test ie thymus daenensi nepeta sessilifolia hymenocrat incanus stachi inflata particular composit essenti oil h incanus complet detect other partial detect oxygen monoterpen main compound essenti oil daenensi sesquiterpen hydrocarbon abund inflata oxygen sesquiterpen main detect h incanus essenti oil essenti oil n sessilifolia main compos non terpen fatti acid due slight differ composit also antibacteri activ affect essenti oil test inde highest antibacteri antifung activ obtain essenti oil daenensi mean inhibit halo mm gram posit strain staphylococcus aureus aspergillus brasiliensi minim inhibitori concentr mic minim bactericidalfungicid concentr mbcmfc essenti oil obtain four speci vari gml strict affect type microorgan test exampl essenti oil h incanus inflata effect gram negat bacterium pseudomona aeruginosa mic gml respect consid one resist bacteri strain therefor essenti oil obtain four speci contain suitabl phytocomplex potenti applic differ commerci area agricultur food pharmaceut cosmet industri moreov essenti oil consid valuabl natur altern synthet antibiot thank abil control growth differ bacteria fungi | D019686;D009822 | T109;T002 |
36,220,838 | neddyl mediat degrad hnrnpab contribut hypertriglyceridemia pancreat hypertriglyceridemia induc acut pancreat htgp character acut excess releas ffa produc pancreat lipas howev under mechan diseas remain poor understood studi describ involv rna bind protein hnrnpab develop htgp use palmit acid pa arj cell creat model htgp vitro rt pcr western blot analys reveal decreas level hnrnpab protein mrna express pa treat cell analys reveal hnrnpab express regul post translat level neddyl restor hnrnpab express use neddyl inhibitor mln protect arj cell pa induc inflammatori injuri prevent nf b activ restor fatti acid oxid cell prolifer furthermor rna immunoprecipit studi demonstr hnrnpab orchestr fatti acid oxid regul express mitochondri trifunct protein mtp administr mln vivo restor hnrnpab protein express pancrea hyperlipidem mice amelior htgp associ inflamm pancreat tissu injuri conclus show hnrnpab central regulatori role prevent htgp induc effect cell metabol viabil furthermor find indic pharmacolog inhibitor target neddyl may provid therapeut benefit htgp patient | D034481;D015228;D010195 | T047;T046;T123;T116 |
36,220,830 | day year studi reveal adolesc fatigu distress day greater co air pollut year day studi examin whether adolesc felt greater fatigu emot distress day day air qualiti wors link object daili air qualiti measur daili self report mexican american adolesc los angel counti california girl age year robust within subject analysi observ reveal adolesc ongo physic complaint report greater fatigu emot distress day air contain higher level nitrogen dioxid carbon monoxid co regardless physic complaint adolesc averag also report greater fatigu day level higher day next day associ air pollut distress mediat via daili increas fatigu result robust control day week daili temperatur humid sulfur dioxid ozon pm pm relat daili fatigu distress | D000393;D000397;D010126 | T069;T131;T080;T103 |
36,220,829 | metabolit profil arabidopsi mutant lower glycolysi previous shown arabidopsi three enzym lower glycolysi name phosphoglycer mutas pgam enolas pyruv kinas form complex play import role tether mitochondria chloroplast given metabol mutant complement pgam mutant overexpress line pgam unclear present gas chromatographi mass spectrometri base metabolom data alongsid plant growth phenotyp compar wild type sugar amino acid concentr signific alter phosphoglycer mutas enolas pyruv kinas convers overexpress pgam could decreas content pga sugar sever amino acid increas content alanin pyruv addit pgam mutant could fulli complement either nuclear target pgam side direct mutat pgam ecoli pgam term plant phenotyp metabolit profil suggest low glycolysi complet format requir support normal metabol growth | D017360 | T002 |
36,220,828 | sequenti action trna base editor convers cytidin pseudouridin post transcript rna edit modul gene express condit depend fashion recent discov c edit vibrio cholera trna character biogenesi regul function previous undescrib rna edit process show enzym trcp mediat edit c u follow convers u consecut alphafold predict trcp consist two globular domain cytidin deaminas pseudouridylas long helic domain latter domain tether trna substrat c u edit pseudouridyl like enabl substrat channel mechan effici catalysi way termin product c edit requir suppress modif creat interdepend network modif trna anticodon loop facilit coupl trna modif state iron avail find provid mechanist insight rna edit process like promot environment adapt | D000926;D011560 | T123;T114 |
36,220,827 | residenti trajectori across life cours associ cognit function later life previous work found later life urban rural differ cognit health larg explain indic cognit reserv educ occup howev previous research concentr resid limit specif period studi offer detail investig associ urban vs rural resid birth cognit function older age use data survey health age retir europ creat residenti trajectori birth survey enrol combin sequenc cluster analysi use mix effect model investig associ residenti trajectori earli mid later life three cognit function outcom immedi recal delay recal verbal fluenci sampl particip found even account differ relat educ occup rural vs urban resid earli life remain associ poorer cognit perform later life suggest grow rural region lead long term disadvantag cognit function thus public health polici consid urban rural inequ earli life may long last associ inequ cognit health old old age | D000073656;D008016 | T067;T102;T079 |
36,220,826 | evolut modul antigen specif cell respons melanoma patient analyz antigen specif cell respons scale challeng analyz three type cell receptor tcr repertoir data antigen specif tcrs tcr repertoir singl cell rna tcr sequenc data patient primari metastat melanoma compar healthi control although melanoma associ antigen maa specif tcrs restrict individu share sequenc similar allow us build classifi predict anti maa cell frequenc anti maa cell distinguish melanoma patient healthi predict metastat recurr primari melanoma anti maa cell stem like properti frequent interact regulatori cell tumor cell via galectin tim pvr tigit axe respect respond patient number expand anti maa clone higher anti pd anti ctla therapi exhaust phenotyp rescu system immunolog approach pave way understand antigen specif respons human disord | D000072597;D008545 | T191;T116;T192 |
36,220,825 | gender stereotyp intellectu abil japanes children japan larg gender gap thus studi examin whether japanes year old children exhibit brillianc male stereotyp whether parent attitud toward gender role relat children stereotyp also explor whether children exhibit stereotyp respons various stimuli show children photo studi stick figur studi men women boy girl ask attribut trait smart nice studi reveal overwhelm group posit girl wherea result boy rather mix studi girl general attribut nice gender compar boy howev brillianc male stereotyp respons observ year age boy began like attribut smart gender compar girl new data studi replic result studi part result studi moreov merg studi data studi confirm find furthermor replic brillianc male stereotyp among year old stick figur task parent attitud toward gender role unrel children gender stereotyp result indic japanes children may acquir brillianc male stereotyp later american children year old furthermor result clearer children present stick figur stimuli | D019956;D013240 | T055;T041;T078;T048 |
36,220,823 | mtorc signal pathway integr estrogen growth factor coordin vagin epitheli cell prolifer differenti mous vagin epithelium cyclic exhibit cell prolifer differenti respons estrogen estrogen act activ mtor signal role vagin epitheli homeostasi unknown analyz reproduct tract specif rptor rictor condit knockout mice reveal role mtor signal estrogen depend vagin epitheli cell prolifer differenti loss rptor rictor vagina result aberr prolifer epitheli cell failur keratin differenti gene express analysi indic sever estrogen mediat gene includ pgr ereg egf like growth factor induc estrogen rptor cko mous vagina moreov supplement ereg could activ prolifer surviv vagin epitheli cell yap absenc rptor thus mtorc signal integr estrogen growth factor signal mediat vagin epitheli cell prolifer differenti provid new insight vagin atrophi treatment post menopaus women | D004815;D004967 | T116;T121;T109;T125;T033 |
36,220,817 | monobodi adapt function antibodi display nanoparticl adapt target deliveri applic vascular endotheli cell ec play central role pathophysiolog mani diseas use target nanoparticl nps deliv therapeut ec could dramat improv efficaci provid elev sustain intracellular drug level howev achiev suffici level np target human set remain elus overcom barrier engin monobodi adapt present antibodi np surfac manner fulli preserv antigen bind function system improv target efficaci cultur ec flow fold convent antibodi immobil use amin coupl enabl robust deliveri nps ec human kidney undergo ex vivo perfus clinic set use organ transplant monobodi adapt also enabl simpl plug play capac facilit evalu divers array target nps technolog potenti simplifi possibl acceler develop clinic translat ec target nanomedicin | D042783;D053758 | T025;T073 |
36,220,816 | whole genom sequenc analysi blood lipid level individu blood lipid herit modifi causal factor coronari arteri diseas despit well describ monogen polygen base dyslipidemia limit remain discoveri lipid associ allel use whole genom sequenc wgs part due limit sampl size ancestr divers interpret clinic signific among ancestr divers non european particip associ variant deep coverag wgs lipid level variant assess prior lipid genet analys find multipl lipid relat gene strong associ blood lipid analysi common rare code variant discov sever associ rare non code variant larg mendelian lipid gene notabl observ rare ldlr intron variant associ mark increas ldl c similar rare ldlr exon variant conclus conduct systemat whole genom scan blood lipid expand allel link lipid multipl ancestri character clinic relev rare non code variant model lipid | D055106;D008055 | T109;T063 |
36,220,815 | caspas inhibit improv cognit without signific alter amyloid inflamm age alzheim diseas mice human genet anim model studi indic brain microgli inflamm primari driver cognit impair alzheim diseas ad inflammasom activ caspas casp associ ad microgli inflamm neuron degener mice casp genet ablat vx small molecul inhibit casp given onset cognit deficit strong support associ microgli inflamm cognit impair vx signific improv episod spatial memori impair eight month onset cognit impair age ad mice signific amyloid beta peptid accumul microgli inflamm unexpect cognit improv associ dendrit spine densiti hippocamp synaptophysin level recoveri vx slight decreas deposit alter biochem measur level furthermor increas hippocamp iba microglia gfap astrocyt il tnf level unalt vx result support hypothesi neuron degener microgli inflamm drive cognit impair ad | D000544;D004660 | T047;T048 |
36,220,814 | sa mediat metabol adapt control hiv persist macrophag vivo hiv erad hinder viral persist cell reservoir establish circulatori cd cell also tissu resid macrophag natur macrophag reservoir mechan persist despit combin anti retrovir therapi cart remain unclear use genit mucosa cart suppress hiv infect individu evalu implic macrophag immunometabol pathway hiv persist demonstr ex vivo macrophag tissu reservoir contain transcript activ hiv viral particl accumul virus contain compart harbor inflammatori il r sa mmp phenotyp prone glycolysi reactiv infecti virus product releas reservoir vitro induc alarmin sa endogen factor produc macrophag implic steril inflamm process metabol depend glycolysi altogeth inflammatori macrophag form major tissu reservoir replic compet hiv reactiv viral product upon autocrineparacrin sa mediat glycolyt stimul hiv persist pathway need target futur hiv erad strategi | D015658;D015497 | T047;T005 |
36,220,811 | ancestr interact modul promot oligomer diverg mitochondri atp synthas mitochondri atp synthas form stabl dimer arrang oligomer assembl generat inner membran curvatur essenti effici energi convers report cryo em structur intact atp synthas dimer trypanosoma brucei ten differ rotat state model consist subunit includ nine lineag specif well lipid rotari mechan influenc diverg peripher stalk confer greater conform flexibl proton transfer lumen half channel occur via chain five order water molecul dimer interfac form subunit g critic interact catalyt activ although overal dimer architectur vari among eukaryot find subunit g togeth subunit e form ancestr oligomer motif share trypanosom mammalian lineag therefor data defin subunit ge modul structur compon determin atp synthas oligomer assembl | D025261 | T126;T116 |
36,220,809 | cue induc cocain crave enhanc psychosoci stress vice versa chronic cocain user stress crave found contribut develop mainten relaps cocain use disord chronic cocain user cu previous research shown display alter physiolog respons psychosoci stress increas veget respond substanc relat cue howev psychosoci stress cue induc crave interact relat cu physiolog respons remain larg unknown thus investig interact acut psychosoci stress cocain cue relat reactiv cu control cross balanc design particip random expos video base cocain cue paradigm trier social stress test tsst vice versa investig possibl mutual augment effect stressor physiolog stress respons cours experiment procedur plasma cortisol acth noradrenalin subject stress crave assess repeat estim respons cocain cue paradigm tsst growth model discontinu growth model use overal though group differ endocrinolog respons tsst cu display lower acth level baselin tsst elev crave cu cocain cue video shown first cu display enhanc cortisol respons subsequ tsst cu cocain cue robust evok crave physiolog stress respons cue induc crave intensifi tsst taken togeth though cu show alter acut stress respons tsst stress crave togeth seem mutual augment effect stress respons | D003042;D019970 | T121;T109;T131;T048 |
36,220,808 | barrier genet test clinic psychiatri way overcom clinician attitud sociocultur differ patient across globe genet test evolv rapid recent year new develop potenti provid insight could improv abil diagnos treat prevent diseas inform obtain genet test proven use specialti cardiolog oncolog nonetheless rang barrier imped techniqu whole exom whole genom sequenc pharmacogenom polygen risk score implement psychiatr practic barrier may procedur eg limit extrapol result individu level econom eg perceiv relat elev cost preclud insur coverag relat clinician knowledg attitud practic eg perceiv unfavor cost effect insuffici understand probabl statist concern regard genet counsel addit sever ethic concern may aris eg increas stigma discrimin exclus health insur provid overview potenti barrier implement genet test psychiatri well depth discuss strategi address challeng | D005820;D011570 | T059;T060;T097;T091 |
36,220,807 | unquantifi mass loss northern hemispher marin termin glacier northern hemispher glacier account glacier area outsid greenland ice sheet termin ocean glacier mass loss ice ocean interfac known frontal ablat yet comprehens quantifi estim decad frontal ablat measur ice discharg terminus posit chang bias correct cross valid estim uncertainti use independ sourc frontal ablat marin termin glacier contribut averag gt ice ocean gt ice discharg equival mm sea level rise compris approxim frontal ablat remaind terminus retreat near coastal area impact includ austfonna svalbard central severnaya zemlya russian arctic alaskan fjord | D046448 | T070 |
36,220,806 | independ origin larg labyrinth size turtl labyrinth vertebr inner ear sensori system govern percept head rotat central hypothes predict labyrinth shape size relat ecolog adapt debat rare test outsid mammal analyz evolut labyrinth morpholog ecolog driver live fossil turtl understudi group underw multipl locomotori transit million year evolut show turtl unexpect larg labyrinth evolv origin aquat habit turtl labyrinth relat larger mammal compar mani bird undermin hypothesi labyrinth size correl direct agil across vertebr also find labyrinth shape variat correl ecolog turtl undermin widespread expect reptilian labyrinth shape convey behavior signal demonstr import understudi group like turtl | D007758;D014426 | T023;T014 |
36,220,799 | brocq geometr phagedena peni keloid scar pyoderma gangrenosum rare neutrophil inflammatori skin disord common seen lower limb involv penil area rare report rare case occurr ulcer type pyoderma gangrenosum peni pustular type elsewher bodi heal keloid immunocompet young man system associ | D017511;D007627 | T047;T020 |
36,220,798 | disast respons use circular economi timelin review literatur construct materi natur build someth invest futur everi project highlight possibl build structur catastroph event render useless landfil grow resourc potenti lost end build need mean end materi part grow momentum behind sustain metric sought invest construct firm alik potenti return invest alreadi exist unit state nation respons framework intern commit like sendai framework disast risk reduct signifi appetit embrac latest innov respons techniqu technolog literatur review focus construct demolit industri lead primari amelior enabl remedi shortfal innov adopt uptak engag appli grow practic circular economi debri manag regimen | D004190;D018505 | T068;T067 |
36,220,797 | offer disast prepared respons train workshop across idaho feasibl studi import individu famili prepar potenti disast enabl communiti generat consolid respons estim percent resid fourth largest citi idaho idaho fall prepar deal disast day train workshop healthcar profession student idaho state univers pocatello organ build capac acut disast respons prepared studi assess impact workshop improv knowledg attitud particip toward disast manag | D004189;D004190 | T064;T067;T052 |
36,220,796 | sex differ inform need media depend california wildfir previous research suggest men women differ number crisi relat behavior includ inform seek behavior media depend california wildfir provid context demograph differ larg unexplor prior emerg communic research focus slower move event hurrican storm surg particip identifi base resid area affect camp woolsey fire n sex differ discov peopl found fire percept medium util inform need implic emerg manag practition discuss | D005390;D000075923 | T067;T070 |
36,220,795 | measur destruct recuper natur gas pipelin system oregon critic energi infrastructur hub portland becom hot spot geolog discuss last year event everyon talk prepar cascadia subduct zone earthquak cascadia categor catastroph natur seismic event juan de fuca plate north american plate subduct northwest coast caus violent respons zone two plate geolog histori shown us everi year major seismic event occur area pacif current disast discuss emerg manag industri author resid last year matter matter cascadia event caus massiv earthquak affect million live cost much current model exist equat follow damag pipe restor disrupt maximum threshold util usag model plan discuss paper cast need spotlight establish new model combin element vital effort made calcul beyond base percentag rate recoveri oregon region lose take regain back busi level oper econom structur environment mani call place nonprofit energi steward determin statist current inform avail easi attain emphas need real time util data | D004190;D055866 | T067;T070 |
36,220,794 | critic decis hurrican evacu bridg roadway closur closur bridg roadway hurrican repres abrupt end evacu resi dent coastal barrier island despit graviti bridg roadway closur hurrican evacu govern polici practic unit state often opaqu poor defin mire confus lack clariti among bridg roadway closur polici rational terminolog well wide dissensus may disrupt public complianc particip hurrican evacu articl argu applic critic decis method cdms analysi hurrican evacu bridg roadway closur mean produc better evid base polici practic use cdm studi decis make expert respons actual work close bridg roadway hurrican evacu help produc detail evi denc base polici compel communic polici greater public complianc hurrican evacu | D055867;D004189 | T064;T052;T070 |
36,220,793 | issu criminolog victimolog secur covid relat quarantin measur purpos studi consid way counter threat crimin legal plane perspect victimolog time studi aim justifi need take comprehens strateg measur take account victimolog threat becam characterist precis spread pandem introduct quarantin measur adopt document set strateg prioriti comprehens pandem respons impli possibl adapt potenti threat similar natur exist document impli possibl develop basi set narrow algorithm action measur ensur victimolog secur citizen event crisi situat due threat pandem research examin current challeng face ukrainian legal system matter criminolog victimolog secur societi quarantin measur relat covid background foreign experi | D000086382;D011790 | T061;T047;T067 |
36,220,792 | hbcus prepared plan respons reopen campus safe covid pandem need asset insight futur emerg disast manag health safeti risk surround covid congreg set colleg campus minim viral transmiss dashboard higher educ leadership understand risk zero like academ institut histor black colleg univers hbcus given great thought make campus consid high risk set safe enough warrant return campus queri hbcu leadership via onlin survey sent hbcus safeti plan fall resumpt campus activ data show hbcus inform two hbcus perman close data gather period thus sampl size specif area queri includ risk manag plan mitig step polici chang human capac resourc also ask leader identifi vulner factor consid plan safe reopen find indic academ institut grappl balanc risk benefit reopen also recogn numer scenario multifacet approach requir recommend present support hbcus futur surmount obstacl implement cultur respons solut best serv campus surround communiti academ institut anchor | D000086382 | T047;T067 |
36,220,765 | influenc kinesiophobia pain catastroph pain induc corticomotor modul healthi particip cross section studi sever studi suggest acut pain decreas corticomotor excit howev variabl patient remain import unexplain aim studi unveil potenti sourc variat look effect kinesiophobia pain catastroph pain induc corticomotor modul | D058443;D002211 | T121;T041;T109;T033 |
36,220,743 | clinic assess earli mobil head neck free flap reconstruct retrospect case control studi examin whether differ periop complic patient mobil first postop day earli mobil mobil second postop day head neck reconstruct use free tissu transfer | D058752;D006258;D019651 | T191;T061;T024 |
36,220,742 | canalicular lacer repair novel bicanalicular silicon tube studi aim investig efficaci safeti canalicular lacer repair use novel bicanalicular silicon tube | D022125;D007765;D007766;D005131;D017695 | T023;T047;T030;T037 |
36,220,733 | unintend intrapleur insert epidur cathet thorac surgeri region analgesia game anoth way thorac surgeri optim pain control crucial prevent dysfunct cardiorespiratori mechan epidur anesthesia ea paravertebr block pvb popular techniqu analgesia unintend intrapleur insert epidur cathet rare complic report present case patient submit pulmonari tumor resect video assist thoracoscop surgeri vat difficulti epidur insert relat patient obes general anesthesia induct addit intraven analgesia need epidur inject surgeri requir convers thoracotomi intrapleur identif epidur cathet end surgeri surgeon reorient cathet paravertebr space leak absenc confirm local anesthet inject cathet postop period pain control effici complic success case show find unexpect complic look altern solut give patient best treatment | D013903;D000767;D000698 | T061;T091 |
36,220,732 | use intraop high frequenc oscillatori ventil neonat pulmonari hypoplasia high frequenc oscillatori ventil hfov ventilatori modal wide use neonat intens care unit main indic restrict lung patholog difficult gas exchang use convent mechan ventil cmv patient receiv cmv requir high intens care immatur lung risk barotrauma volutrauma studi explor use hfov oper room main limit hfvo congenit diaphragmat hernia repair limit experi ventilatori method oper room may disadvantag anesthesiologist howev import rememb benefit techniqu lung protect strategi report two case neonat pulmonari hypoplasia differ etiolog good oxygen ventil achiev intraop hfov | D006612;D065630;D003586 | T061;T047;T019 |
36,220,728 | new ultrasound guid capsular block hip surgeri narrat review surgeri hip joint common improv pain manag one fundament pillar optim function recoveri patient must design multimod anesthet analges plan cover entir periop period peripher nerv block fascial block import compon multimod analges strategi tradit block moder efficaci prolong motor impair increas risk fall altern capsular block ileopsoa plane block ipb pericapsular nerv group block peng block recent describ aim avoid motor impair maintain optim analges efficaci object review describ new capsular block analyz whether allow improv postop analgesia promot function recoveri fewer complic base innerv hip bibliograph review carri pubm embas cochran librari databas januari june | D009407;D000765 | T061 |
36,220,717 | post acut anti nmdar enceph mirror schizophrenia post acut evolut cognit psychiatr featur anti n methyl aspart receptor nmdar enceph poor investig far recent work publish lancet neurolog guasp et al report neuropsychiatr symptom post acut phase mirror observ schizophrenia although patient anti nmdar enceph show improv symptom | D060426;D012559 | T047;T048 |
36,220,716 | safeti immunogen live attenu intranas bordetella pertussi vaccin bpze healthi adult bpze live attenu pertussi vaccin deriv b pertussi strain tohama modifi genet remov inactiv b pertussi toxin pertussi toxin dermonecrot toxin tracheal cytotoxin phase studi evalu safeti immunogen liquid lyophil bpze vaccin administ intranas needleless tuberculin syring mucos atom devic vaxin tm two dose level | D010567;D014917 | T121;T047;T116;T129 |
36,220,715 | scarier flu shot social determin shingl influenza vaccin among us older adult although half older adult receiv annual influenza vaccin flu shot one third ever vaccin shingl mind studi examin associ sociodemograph characterist health behavior vaccin uptak differ two virus also investig whether social predictor shingl vaccin chang rollout new vaccin | D007252;D007251;D053061;D000086382;D006562 | T047;T121;T109;T129;T067 |
36,220,714 | covid vaccin percept hesit amongst parent school age children pediatr vaccin rollout unit state highest number total case death due coronavirus diseas covid worldwid john hopkin covid dashboard despit covid vaccin avail uptak unit state slow vaccin hesit signific barrier achiev widespread vaccin uptak understand determin vaccin accept essenti implement success popul health intervent increas covid vaccin | D007252;D000086382 | T047;T121;T109;T129;T067 |
36,220,696 | antineoplast drug induc nausea vomit pediatr onco hematolog guidelin support care committe french societi childhood cancer sfce nausea vomit induc cancer treatment cinv remain one common fear side effect children despit use new drug prevent exist recommend prophylaxi treatment cinv base adult patient anglo saxon societi base recent review literatur focus specif pediatr issu order offer recommend valid support care committe french societi childhood cancer | D000932;D009369;D000970;D006405 | T121;T191;T091;T109;T039 |
36,220,689 | mirna effect gut homeostasi therapeut implic inflammatori bowel diseas inflammatori bowel diseas ibd span rang chronic condit affect gastrointestin gi tract mark intermitt flare up remiss ibd result microbi dysbiosi defect mucos barrier gut trigger inappropri immun respons genet suscept person alter immun microbiom axi review discuss regulatori role mirna small noncod rnas gene regulatori function stabil mainten gut immun microbiom axi detail challeng recent advanc use mirna putat therapeut agent treat ibd | D035683;D015212 | T047;T123;T114 |
36,220,663 | applic machin learn diagnosi keratoconus diagnosi keratoconus close relat artifici intellig machin learn core artifici intellig machin learn model combin corneal inform effect supplement keratoconus diagnosi provid decis support artifici intellig system bring effici reduc artifici misjudg effect reduc manpow cost paper summar previous machin learn model assist diagnosi keratoconus may help research understand relev knowledg field intellig diagnosi keratoconus great signific machin learn research | D007640 | T047 |
36,220,662 | advanc tight junction damag corneal epitheli barrier pathogenesi corneal diseas cornea transpar tissu signific refract barrier function corneal epithelium constitut first line defens foreign pathogen corneal epitheli cell interact form function select permeabl barrier dysfunct barrier lead corneal impair follow seri ocular surfac diseas even blind tight junction tj locat top intercellular space corneal epitheli superfici cell play critic role establish maintain barrier function previous studi shown destruct tj act crucial step occurr progress multipl ocular surfac diseas understand fundament featur function tj notic risk factor tj disrupt clarifi key role tj pathogenesi various ocular surfac diseas help better understand treat ocular surfac diseas | D003316;D019573 | T047;T024 |
36,220,661 | advanc optic disc morpholog featur peripapillari structur chang high myopia high myopia import caus low vision blind world character prolong axial length accompani various degen chang fundus posterior pole especi optic disc area peripapillari structur optic disc tilt optic cup rim chang chorioretin atrophi posterior staphyloma intrachoroid cavit articl review optic disc morpholog featur peripapillari structur chang high myopia order reveal pathogenesi high myopia provid new idea find effect prevent treatment method | D015862;D009216;D009898;D015422 | T047;T023;T033 |
36,220,660 | advanc research intestin flora ophthalm diseas larg number commens bacteria settl intestin play import role maintain normal function intestin regul host immun metabol recent year research found intestin flora involv occurr deterior various extraintestin diseas ophthalm diseas uveiti age relat macular degener glaucoma also affect intestin flora intestin flora metabolit differ circumst chang bodi immun homeostasi regul multipl metabol pathway induc autoimmun respons eye promot chronic inflamm articl review relationship intestin flora ophthalm diseas provid new research idea pathogenesi intervent various ophthalm diseas | D000069196;D014605 | T007;T001;T047 |
36,220,659 | advanc nanomateri appli ophthalm treatment nanomateri use mani aspect ophthalm treatment emphas ubiquit characterist nanoparticl composit first explain relat matur applic drug deliveri review research nanomateri regen medicin gene therapi recent year also discuss main limit wider applic nanomateri ophthalmolog stabil biotox preclin clinic differ develop effici non toxic nanomateri combin appropri transport system applic occas provid possibl futur applic nanomateri ophthalm treatment | D049329;D009885 | T091;T073 |
36,220,658 | research advanc human corneal endotheli cell regener human corneal endotheli cell hcec prerequisit maintain corneal transpar hcec remain arrest g phase embryon develop prolifer regener thus densiti hcec decreas spontan corneal develop system factor primari corneal diseas refract factor glaucoma inflamm trauma caus massiv loss hcec lead corneal edema turbid ultim induc blind current keratoplasti effect treatment scarciti donor cornea limit corneal preserv technolog restrict avail keratoplasti therefor appeal way tackl tissu shortag problem corneal endotheli cell regener recent year endogen regener hcec mediat surgeri drug gene therapi also exogen regener hcec mediat cell therapi made fruit progress although number regener strategi enter clinic trial stage wide clinic applic corneal endotheli regener still far away review elabor basic research clinic applic limit current strategi corneal endotheli cell regener | D016039;D042783 | T061;T025 |
36,220,657 | case report smile refract regress nine year myopia correct laser situ keratomileusi myopic patient self report photorefract keratectomi year ago request small incis lenticul extract smile retreat presenc interfac bubbl creat corneal cap right eye reveal previous refract surgeri laser situ keratomileusi lasik therefor smile procedur resum right eye flap lift lasik perform left eye postop follow show vision eye reach preoper best correct level smile may potenti option refract regress lasik | D020731;D009216 | T061;T047 |
36,220,656 | keratoconus transepitheli photorefract keratectomi case report year old male treat transepitheli photorefract keratectomi myopia eye year ago allerg conjunct year night vision eye decreas year clinic diagnosi keratoconus binoculus therefor corneal collagen cross link perform eye follow month confoc microscopi show cross link riboflavin fiber amino success keratoconus progress follow although case report keratoconus transepitheli photorefract keratectomi home abroad great import attach earli comprehens screen keratoconus candid refract surgeri order improv long term safeti | D007640;D010778;D018903 | T061;T047 |
36,220,655 | case autolog corneal stromal lenticul transplant vision function train correct hyperopia hypermetrop anisometropia often accompani visual fatigu higher hyperopia prone form amblyopia avoid wear glass fatigu higher hyperopia often correct regul spasm pseudomyopia may occur earli stage refract surgeri case autolog corneal stromal lenticul transplant use correct hyperopia standard visual cognit train uncorrect distanc visual acuiti rapid improv binocular vision normal | D015858;D006956;D015354 | T047 |
36,220,654 | case bacteri kerat lamellar keratoplasti pterygium year old man present beij tongren hospit ophthalmolog depart red increas secret vision loss right eye treat pterygium excis lamellar keratoplasti due recurr pterygium right eye corneal scrape microbi cultur diagnos bacteri kerat pterygium lamellar keratoplasti right eye appli topic antibiot eye drop remov corneal graft conduct amniot membran transplant corneal infect control vision recov | D016039;D015818;D007634;D011625 | T061;T047 |
36,220,653 | two case wolfram syndrom two adolesc tdm particip shanghai children adolesc dm eye studi scade previous tdm histori children year year respect histori optic atrophi year year respect ophthalm examin show slight posterior capsul cataract atrophi optic atrophi patient optic coher tomograph examin show choroid thick inferior inner ring optic nerv rnfl layer thick decreas mark perfus densiti vascular densiti optic disc area macular decreas mark electrophysiolog examin show amplitud decreas mark visual field examin show binocular extinct tubular vision field adolesc close follow suggest children tdm whose best correct visual acuiti decreas recent lower addit routin ophthalm examin choroid thick retin nerv fiber layer thick retin blood flow erg visual field examin recommend distinguish wolfram syndrom tdm genet sequenc examin wfs also recommend possibl | D003922;D009896;D014929 | T047 |
36,220,652 | glaucoma secondari juvenil xanthogranuloma children case report month old boy admit hospit parent notic fog right eye day physic examin reveal multipl light brown macul skin intraocular pressur iop right eye mmhg mmhgkpa corneal enlarg edema aqueous humor cloudi blood right eye yellow peripher anterior synechia seen tempor inferior iri ultrasound biomicroscopi ubm show extens adhes closur anterior chamber angl local thicken iri nodul obvious abnorm observ left eye confirm juvenil xanthogranuloma skin lesion biopsi iop normal system local therapi corticosteroid local iop lower medic follow month iop normal without medic | D005901;D015812;D014972 | T191;T047 |
36,220,651 | case gm gangliosidos articl describ case seek medic advic month due retrogress develop discoveri characterist fundus macular cherri red spot key clue genet analysi glb compound heterozyg mutat detect enzymolog result show acid b galactos glucosid enzym signific decreas fundus inspect help diagnosi gm gangliosidos | D005733 | T047 |
36,220,650 | case mild zellweg spectrum disord first diagnos usher syndrom year old femal patient present night blind poor hear year whose first diagnosi usher syndrom due retin pigmentosa accompani sensorineur deaf compound heterozyg variant cg pw cc pps pex causat gene zellweg spectrum disord confirm target exom sequenc analysi perman tooth enamel dysplasia nail leukoplakia biochem abnorm peroxisom consist mild zellweg spectrum disord found follow | D012174;D052245;D015211 | T047 |
36,220,649 | clinic manifest case herp simplex virus kerat object explor demograph distribut clinic sign clinic type herp simplex virus kerat hsk method retrospect case seri data case hsk eye diagnos beij tongren eye center beij tongren hospit capit medic univers januari june collect patient includ male femal age year inform patient age sex season onset eye later clinic sign assess slit lamp microscopi corneal fluorescein stain use locat anatom posit lesion hsk classifi epitheli type neurotroph type stromal type endotheli type mix type distribut data compar chi squar test fisher exact test result children year old youth year old middl age year old elder year old patient type epitheli case neurotroph case stromal case endotheli case mix case statist signific differ clinic type among differ age group p epitheli hsk found male femal neurotroph hsk male femal stromal hsk male femal endotheli hsk male femal mix hsk male femal statist signific differ clinic classif kerat gender p among case mix type case epitheli stromal type case epitheli endotheli type case stromal endotheli type case epitheli neurotroph type case neurotroph stromal type conclus hsk occur main middl age young adult rare children proport male higher femal proport stromal hsk highest patient present mix hsk | D016849 | T047 |
36,220,648 | preval risk factor pterygium six rural region yunnan provinc object investig preval risk factor pterygium rural popul age year ethnic group region yunnan provinc method cross section studi accord method multistag stratifi sampl sampl rural popul age year collect ethnic group han yi tibetan lisu bai naxi zhuang miao dai jingpo hani lahu six area diqe lijiang wenshan dehong puer yunnan provinc march novemb anterior segment examin carri target popul hand held slit lamp accord pterygium diagnos posterior segment eye assess direct ophthalmoscopi field questionnair survey also conduct two level model use studi effect locat nation sex age occup outdoor activ smoke alcohol consumpt preval pterygium ethnic group high level individu low level result among subject total preval rate pterygium adjust accord age gender data statist bureau yunnan provinc signific differ preval pterygium among six region adjust age sex p preval pterygium highest wenshan follow chuxiong diqe puer dehong lijiang p result singl factor analysi show statist signific differ among differ group age gender nation locat histori smoke drink eat habit sleep time continu use eye drop temperatur humid altitud longitud latitud ultraviolet ray p howev result multivari analysi show main risk factor pterygium femal ci advanc age ci locat ci continu use eye drop ci year alcohol drink ci protect factor year smoke ci conclus preval pterygium vari great among differ region yunnan provinc main factor affect preval sex age region smoke histori drink histori | D011625 | T047 |
36,220,647 | impact diabet retinopathi vision relat qualiti life object assess effect diabet retinopathi dr vision relat qualiti life vrqol patient type diabet method cross section studi patient type diabet resid resid communiti fushun liaon provinc enrol juli may measur vrqol item nation eye institut visual function questionnair nei vfq patient group accord age gender presenc visual impair affect eye nei vfq score compar betweenamong group use wilcoxon rank sum test kruskal walli h test sever dr eye grade dr mild non prolif diabet retinopathi npdr moder npdr sever npdr prolif diabet retinopathi pdr sever score eye summar creat singl per person grade rang dr either eye bilater pdr general linear model use assess linear relationship nei vfq score dr sever local weight scatterplot smooth plot generat evalu possibl nonlinear associ concaten sever dr vrqol result total patient recruit includ dr mild npdr moder npdr sever npdr pdr compar patient unilater dr bilater involv subject statist signific compromis general vision vs z p near activ vs z p depend vs z p mental health vs z p role difficulti vs z p nei vfq composit vs z p score general vision near activ distanc activ social function depend mental health role difficulti color vision peripher vision nei vfq composit decreas gradual dr sever increas p mild npdr slope moder npdrmoder npdr sever npdrsever npdr slope conclus greater sever bilater dr associ lower vision specif vrqol particular role difficulti mental health | D003924;D003930 | T047 |
36,220,646 | chines expert consensus femtosecond laser assist keratoplasti corneal transplant divid therapeut keratoplasti optic keratoplasti main method restor vision patient corneal blind key optic keratoplasti regular excis prepar donor recipi cornea well well develop sutur skill reduc surgic induc astigmat tradit keratoplasti main reli trephin prepar corneal graft recipi bed procedur lack precis import factor affect postop vision recoveri regard femtosecond laser assist keratoplasti flak get precis result compar tradit trephin assist keratoplasti therebi achiev better optic keratoplasti effect flak requir cooper corneal refract surgeon corneal transplant surgeon surgic procedur also differ tradit trephin assist keratoplasti promot standard implement flak china provid guidanc clinic practic cornea group ophthalmolog branch chines medic associ formul consensus indic surgic design procedur complic periop medic manag flak thorough discuss domest foreign research result collect combin clinic experi expert field | D016039;D015948 | T061 |
36,220,645 | challeng artifici intellig use eye diseas screen recent china communiti due factor medic resourc public awar fund general screen optim screen model communiti base screen far meet demand artifici intellig ai replac medic work combin internet model transfer medic resourc improv access avail howev applic ai technolog communiti base screen still face mani challeng ai product direct appli communiti base screen inabl integr multimod inform medic histori symptom imag lack relev regul health polici product implement therefor suggest relev depart take action build standard big data set unlock data barrier acceler develop applic ai technolog train ai medic staff soon possibl establish relev law regul establish relev r plan qualiti standard regulatori framework ai product encourag invest medic ai infrastructur central western region remot poor area | D001185;D005128 | T090;T047;T066;T073 |
36,220,644 | ensur univers eye health coverag acceler progress toward achiev sustain develop goal unit nation sign vision everyon acceler action achiev sustain develop goal are th un session commit great effort improv eye health global address increas impact vision loss sustain develop first agreement design tackl prevent sight loss adopt unit nation enshrin eye health integr part univers health coverag resolut summar lesson learn previous global eye health practic set target eye care countri set ensur full access eye care servic popul support global effort make eye care part nation journey achiev sustain develop goal sdg global initi also signific impact eye health china implement unit nation general assembl resolut promot continu develop eye health china | D000076502;D019472 | T068;T078;T067 |
36,220,632 | toward model thrombosi thromboembol laminar turbul flow regim thrombosi thromboembol dead risk factor blood contact biomed devic silico model thrombosi attract tool understand mechan process though simul thromboembol remain underdevelop purpos studi modifi exist comput thrombosi model allow thromboembol investig behavior modifi model rang flow rate new exist model observ lead similar predict thrombosi canon backward face step geometri across flow rate neither model predict thrombosi turbul flow simul perform increas flow rate case clot form lower flow induc embol embol observ clot breakdown shear rather breakup subsequ transport clot materi work requir formul valid embol model provid framework investig thromboembol | D013923;D013927 | T046 |
36,220,621 | neuron lack pdea disrupt work memori spatial learn memori facilit cu fear memori mice pdes regul camp level critic pka activ depend activ creb mediat transcript learn memori inhibitor pdes like pde pde improv learn memori rodent howev role pde cognit learn memori report yet | D054732;D008570;D065853;D054708 | T041;T126;T116 |
36,220,612 | n termin mutant huntingtin deposit correl cag repeat length symptom onset neuron loss huntington diseas huntington diseas hd caus cag repeat expans mutat gene encod huntingtin htt protein mutant htt protein subsequ form aggreg within brain mutant htt current target novel therapeut strategi hd howev lack translat preclin research diseas modifi treatment highlight need improv understand role htt protein human brain studi aim undertak immunohistochem screen candid antibodi various sequenc along htt protein character htt distribut express post mortem human brain tissu microarray tmas immunohistochemistri perform middl tempor gyrus tmas compris hd age match control case use antibodi specif various sequenc along htt protein studi six antibodi direct htt n terminus success immunolabel human brain tissu htt aggreg htt protein express level six success antibodi subsequ quantifi custom autom imag analysi pipelin tmas fold increas number htt aggreg detect hd case use antibodi mab mw epr despit chang overal htt protein express compar control case suggest redistribut htt aggreg hd mab mw epr htt aggreg number posit correl cag repeat length negat correl age symptom onset hd howev number htt aggreg correl degre striatal degener degre cortic neuron loss togeth result suggest longer cag repeat length correl htt aggreg hd human brain greater htt cortic aggreg deposit associ earlier age symptom onset hd studi also reinforc antibodi mab mw b util character htt anim model hd specif immunolabel htt aggreg hd human brain tissu exclus therebi highlight need valid mean htt detect support drug develop hd | D006816 | T047 |
36,220,611 | alter sensit acut stress induc anxieti relat behavior modul insular cortex paraventricular thalamus bed nucleus stria terminali neural circuit dysregul neuron network contribut etiolog psychiatr diseas includ anxieti howev neural circuit under anxieti symptom remain unidentifi observ acut restraint stress activ excitatori neuron paraventricular thalamus pvt activ pvt neuron caus anxious behavior wherea suppress pvt neuron activ induc anxiolyt effect achiev use chemogenet method moreov found pvt neuron show plenti neuron project bed nucleus stria terminali bnst activ pvt bnst neural project increas suscept stress induc anxieti relat behavior inhibit neural circuit produc anxiolysi insular cortex ic import upstream region project pvt activ ic pvt neuron project enhanc suscept stress induc anxious behavior inhibit neural circuit suppress anxious behavior moreov anterograd monosynapt trace result show ic exert strong neuron project pvt form synapt connect neuron neuron throw extens neuron fiber form synaps bnst neuron final result show ablat neuron pvt receiv monosynapt input ic attenu anxieti relat phenotyp induc activ ic neuron lesion neuron bnst synapt origin pvt block anxieti relat phenotyp induc activ pvt neuron find indic pvt crucial anxieti regul nucleus ic pvt bnst neural project essenti pathway affect anxieti morbid treatment | D012686 | T023 |
36,220,609 | statist physic approach diseas modul detect extens evid indic pathobiolog process complex diseas associ perturb specif neighborhood human protein protein interact ppi network also known interactom often refer diseas modul mani comput method develop integr interactom omic profil extract context depend diseas modul yet exist method fundament limit term rigor andor effici develop statist physic approach base random field ise model rfim diseas modul detect mathemat rigor comput effici appli rfim approach genom wide associ studi gwas ten complex diseas examin perform diseas modul detect found rfim approach outperform exist method term comput effici connect diseas modul robust interactom incomplet | D055106;D060066 | T169;T063 |
36,220,582 | heterogen dispar life expect across us metropolitan area life expect unit state declin sinc character dispar within across metropolitan area countri lack | D000086382 | T047;T067 |
36,220,581 | log transform independ variabl must epidemiolog studi often quantifi exposur use biomark common statist skew distribut although normal assumpt requir biomark use independ variabl linear regress becom common practic log transform biomark concentr transform motiv concern nonlinear dose respons relationship outlier howev transform may alway reduc bias studi evalu valid motiv under decis log transform independ variabl use simul consid eight scenario give rise skew x normal simul studi demonstr skew exposur aris bias factor eg measur error analyt approach best overal model fit best reflect under outcom generat method least bias regardless skew x estim bias skew exposur consequ bias factor addit illustr process determin whether transform independ variabl need use nhane studi suggest divorc shape exposur distribut decis log transform may aid research plan analysi use biomark skew independ variabl | D009749 | T062 |
36,220,580 | exact mediat analysi ordin outcom binari mediat refer singl mediat context brief report present model base strategi estim counterfactu direct indirect effect respons variabl ordin mediat binari postul logist regress model mediat cumul logit model outcom present exact parametr formul causal effect therebi extend previous work contain approxim result identif condit equival one alreadi establish literatur effect estim make use standard statist softwar standard error comput via bootstrap algorithm make methodolog access routin implement propos r present eappendix http linkslwwcomedeb also deriv natur effect model coher postul data generat mechan | D000465;D000081983 | T169;T170;T062 |
36,220,579 | convent definit path specif effect fulli mediat interact multipl order mediat path specif effect critic measur assess mediat presenc multipl mediat howev convent definit path specif effect generat controversi often caus misinterpret result multipl mediat analysi depth analysi issu propos concept decompos fulli mediat interact averag causal effect show misclassif fulli mediat interact main caus misinterpret path specif effect propos two strategi specifi fulli mediat interact isol reclassifi fulli mediat interact choic strategi depend object isol fulli mediat interact superior strategi main object elucid mediat mechan wherea reclassifi superior main object precis interpret mediat analysi result compar perform studi use two propos strategi convent decomposit strategi analyz mediat role dyspnea anxieti effect impair lung function poor health status popul patient chronic obstruct pulmonari diseas estim result show convent decomposit strategi underestim import dyspnea mechan diseas specif strategi reclassifi fulli mediat interact reveal averag causal effect attribut mediat effect particular mediat effect dyspnea | D029424 | T047 |
36,220,578 | arbuscular mycorrhiz fungus rhizophagus irregulari impact physiolog biochem respons ryegrass chickpea plant beryllium stress heavi metal beryllium identifi toxic plant negat impact plant growth therefor urgent need environment friend techniqu reduc toxic plant growth product end arbuscular mycorrhiz fungi amf wide appli induc plant growth stress toler howev amf plant symbiosi support plant stress studi accord investig physiolog biochem respons amf inocul ryegrass chickpea plant stress associ chang uptak accumul photosynthesi oxid stress carbon nitrogen metabol studi soil contamin induc higher accumul particular ryegrass consequenti reduc plant growth photosynthesi howev photorespir oxid damag h accumul lipid oxid lox activ increas main ryegrass plant speci amf inocul reduc accumul mitig growth inhibit oxid damag extent ryegrass could explain improv photosynthesi well upregul osmoprotect ie sucros prolin biosynthesi pathway increas prolin level consist higher nitrogen n metabol reflect n level nitrat reductas speci specif respons record support princip compon analysi studi provid insight mechan amf impact stress ryegrass chickpea plant henc current research suggest amf inocul could use viabl strategi mitig phytotox ryegrass chickpea plant | D038821;D008129;D029863 | T168;T004;T002 |
36,220,577 | human exposur phthalat ester soil embodi interregion food trade china ubiquit occurr phthalat ester pae agricultur soil result inevit accumul crop potenti increas risk human exposur pae via daili food intak dietari health risk pae depend local produc food also import food region howev impact interregion food trade human dietari exposur pae seldom assess herein investig impact interregion food trade dietari exposur pae contribut soil contamin china averag daili dietari intak pae chines general popul gkgday assum total consumpt crop local market averag daili dietari intak pae chines general popul decreas effect interregion food trade involv calcul addit interregion food trade remark increas daili dietari intak pae region beij tianjin region north central result hazard quotient valu pae region beij tianjin region north central increas respect owe consumpt import crop high pae contamin region contrast daili intak hazard quotient valu pae region central coast northwest northeast south coast decreas due interregion trade result indic interregion food trade promot transfer pae region thus alter potenti risk local popul overal studi highlight import take interregion food trade account provid accur risk assess dietari exposur pollut | D012989;D010795 | T109;T131 |
36,220,576 | assess role gut microbiom interfac environment chemic exposur human health current knowledg challeng explos microbiom research past decad shed light various way extern factor interact human microbiom drive health diseas individu expos environment chemic everi day accumul evid indic microbiom involv earli respons environment toxic biolog mediat advers effect human health howev review articl date provid comprehens framework research translat role gut microbiom environment health scienc review summar current evid environment compound effect gut microbiom discuss involv compound metabol pathway cover environment pollut induc gut microbiota disord long term outcom host health conclud gut microbiota may crucial mediat modifi diseas caus effect environment chemic consequ gut microbiota need studi assess complet toxic environment exposur futur research field requir delin key interact intestin microbiota environment pollut elucid long term human health effect | D000069196;D064307;D004785 | T007;T131;T028;T001;T032 |
36,220,575 | sahmap synergist antagonist heatmap evalu combin synergist effect mixtur three pesticid multipl endpoint caenorhabd elegan environment pollut caus toxic chemic pesticid becom global problem mixtur dichlorvo dic dimetho dim aldicarb ald pose potenti risk environ human health fulli explor interact complex mixtur caenorhabd elegan behavior toxic endpoint studi creat synergist antagonist heatmap sahmap base combin index systemat describ toxicolog interact prospect mixtur system shown three pesticid binari well ternari mixtur ray signific concentr respons relationship three behavior endpoint nematod perspect synergist antagonist heatmap mixtur ray dic dim mixtur system show strong synerg three behavior lethal endpoint ternari mixtur system five mixtur ray show differ interact behavior endpoint lethal endpoint show slight synerg two behavior endpoint whole emerg synerg arous attent hazard chemic addit use sahmap signific linear correl among three behavior endpoint improv effici studi behavior toxic pesticid mixtur caenorhabd elegan | D010575 | T131 |
36,220,574 | assess bpa bps exposur general popul guangzhou china estim daili intak base urinari metabolit human exposur bisphenol bpa bisphenol bps garner consider global health concern paper daili intak di bpa bps general popul guangzhou china back calcul use biomark bpa glucuronid bpa g bps glucuronid bps g respect biomark prefer total bpa bps measur suscept extern contamin total urin sampl gather general popul guangzhou china classifi age sex pool urin sampl pool urin sampl contain bpa g bps g median valu ngml respect base urinari bpa g bps g concentr determin median di bpa bps ng kg bw respect highest valu ng kg bw ng kg bw respect furthermor result show entir dataset di bpa bps consider greater male femal p declin signific age p risk assess estim dis bpa bps much lower european food safeti author efsa temporari accept refer dose g kg bw advis bpa suggest exposur risk bpa bps guangzhou popul within control safeti rang first studi investig bpa bps exposur general popul guangzhou china basi urinari metabolit | D001559;D013450 | T121;T109 |
36,220,573 | hif mediat autophagi canon wnt catenin signal activ involv fluorid induc osteosclerosi rat fluorid f exposur caus osteosclerosi characteris high bone mass mechan fulli illustr aim evalu effect excess f exposur bone lesion treat femal spragu dawley rat differ concentr sodium fluorid naf mgl day correspond concentr fluorin ion mgl respect histopatholog result show excess f exposur caus enlarg trabecula integr one larg piec growth plate thicken articular cartilag impair bone collagen abnorm meanwhil f promot calcium deposit bone mineralis induc abnorm osteogenesi increas result micro comput tomographi also confirm excess f destroy bone microstructur induc high bone mass phenotyp consist result pathomorpholog mechanist excess amount f led angiogenesi inhibit hif signal enhanc subsequ f induc autophagi canon wnt catenin signal pathway activ collect result manifest f enhanc hypoxia induc factor signal turn trigger autophagi canon wnt catenin signal activ ultim lead osteosclerosi rat | D051176;D010026 | T047;T123;T116 |
36,220,572 | interact microplast soil pollut soil plant system recent year increas studi report character detect microplast mps interact organ pollut op heavi metal hms soil howev comprehens review characterist factor influenc mps distribut soil sorption characterist mechan soil contamin mps especi interact mps complex pollut soil plant system remain rare avail present review focus sorption featur mechan pollut mps soil discuss effect mps complex pollut soil properti microb plant polar mps signific influenc sorption op differ sorption mechan involv hydrophob hydrophil op sorption op mps soil differ water age mps promot sorption migrat contamin enhanc effect biofilm microplastispher sorption pollut mps critic interact soil environ mps microb hms antibiot increas potenti pathogen larger releas resist gene coexist hms mps affect growth plant uptak hms mps plant moreov type dose shape particl size mps import influenc interact pollut subsequ effect soil properti microbi activ plant growth review also point knowledg gap construct countermeasur promot futur research field | D012989;D019216;D004785;D014874 | T131;T196 |
36,220,571 | identifi quantifi pm pollut episod fusion method move window techniqu constrain posit matrix factor pm pollut episod rapid signific deterior air qualiti critic concern worldwid studi develop fusion method base move window dataset techniqu constrain posit matrix factor pmf differenti character potenti factor pm episod case assum one new contributor hour pm composit element ion carbonac compon collect septemb decemb taipei taiwan constraint target base bootstrap analysi result pmf model use long term input dataset impos model move window ensur similar featur retriev factor constitu addit differenti factor episod identifi region transport stabl among move window cover occurr episod reveal profil match index result show largest contributor pm mass episod period region transport wherea regular pollut industryammonium sulfat relat accord review literatur studi first appli move window techniqu constrain pmf character episod find provid valuabl inform use explor caus pm episod implement air pollut control strategi | D000393;D000397 | T069;T131;T080 |
36,220,570 | aerocyt specif lung adapt breath depend altern splice chang adapt breath critic step lung function crucial organism surviv alveoli lung gas exchang unit develop late embryon earli postnat stage requir feedback multipl cell type howev crosstalk alveolar cell type modul anticip lung adapt breath still unclear uncov synchron altern splice switch multipl gene develop mous lung transit birth identifi hnrnp cpeb elavlhub putat splice regul transit notabl found vegfa switch vegfa isoform longer vegfa isoform exclus lung alveolar epitheli cell function analysi reveal vegfa vegfa drive specif car posit aerocyt subtyp alveolar endotheli cell special gas exchang result reveal cell type specif regul vegfa altern splice birth modul epitheli endotheli crosstalk develop alveoli promot lung adapt breath | D017398;D042783 | T025;T045;T123;T114 |
36,220,567 | onlin liquor get audit review regulatori control suppli practic onlin liquor retail nsw australia new south wale nsw australia number onlin liquor licenc packag liquor licenc condit restrict sale alcohol onlin phone fax order increas may intern nation evid emerg growth onlin liquor licenc accompani increas risk suppli young intox peopl studi aim determin extent onlin liquor retail nsw adopt safeguard prevent peopl younger year purchas alcohol onlin suppli alcohol intox peopl also aim assess regulatori framework nsw licenc | D000434;D003132 | T081;T078;T057;T168;T097 |
36,220,566 | chang public support alcohol polici nsw australia alcohol contribut signific health social econom burden worldwid evid base polici option reduc harm associ alcohol use aim paper understand factor influenc public support various alcohol polici new south wale nsw australia determin chang time | D000428;D009369 | T191;T055 |
36,220,565 | true cost hidden wait time cataract surgeri australia cataract surgeri safe effect common elect procedur australia access inequit true wait time cataract care undisclos inconsist report govern estim true wait time rang month extend coronavirus diseas covid pandem compar analysi reveal reduc wait period month would result estim public health system cost save million prevent fall invest public cataract servic address current unmet need would prevent avoid vision impair associ negat consequ | D000086382;D002386;D002387 | T047;T061;T190;T067;T033 |
36,220,564 | health servic approach provid care peopl seek treatment obes identifi challeng way forward paper aim identifi challeng current health servic approach provid optim care peopl seek treatment obes type program servic health servic manag obes australia method draw live experi clinic academ perspect avail evid reflect current state healthcar system support peopl seek treatment obes suggest action enabl effect accept equit care group peopl | D003695;D009313 | T093;T058;T170 |
36,220,563 | polici healthcar support preconcept plan weight manag optimis long term health women children explor opportun chang increas weight gain trajectori women reproduct live focus optimis health pregnanc type program identifi optim polici health promot health servic support preconcept health women focus achiev healthi weight | D063766;D016742 | T047;T058;T033 |
36,220,562 | call join action promot nutrit across first day life use food system approach nutrit across first day life concept age five consid critic shape lifelong nutrit health outcom dietari pattern track infanc later childhood adulthood identifi potenti polici programmat research opportun essenti inform action area | D000067576;D019649 | T078;T058;T057 |
36,220,561 | inequ obes indigen cultur linguist divers disabl perspect popul group includ aborigin torr strait island peopl peopl disabl peopl cultur linguist divers communiti cald experi health inequ result dispar diseas rate includ higher rate obes associ chronic diseas paper bring togeth three perspect research field indigen health disabl cald health examin overweight obes impact popul australia put forward way address problem author urg invest research co design peopl communiti live experi obes build valuabl knowledg prevent action intervent work reduc obes rate call evid base tailor obes prevent program address histor dispar improv health outcom among australia disadvantag popul | D006233;D006303 | T101;T058 |
36,220,560 | weight stigma australia public health call action peopl live obes experi weight stigma social set negat impact health qualiti life primari contributor weight stigma misconcept obes caus factor sole within individu control howev disregard complex multifacet natur obes weight stigma perpetu media healthcar practition research even public health campaign polici design help peopl live obes perspect articl public health call action address weight stigma australia provid key recommend public health research practition polici maker | D000079322 | T054 |
36,220,559 | adolesc young adulthood untap window opportun obes prevent adolesc young adulthood aya format life stage second first day yet young peopl histor forgotten health system major health risk factor like adolesc obes larg left untreat result signific chronic diseas burden health cost later life australia strategi address obes primarili implement disjoint differ jurisdict govern meant obes respons across countri piecem current state base intervent show modest effect improv weight relat behaviour major fiscal regulatori measur yet implement despit demonstr public health benefit public support new nation obes strategi recognis import engag youth welcom approach coordin obes prevent australia wide challeng remain ensur meaning aya engag follow futur intervent digitalis societi pose futur health challeng aya likelihood greater physic inact eas access junk food | D063766 | T047;T033 |
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