PMID
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36.4M
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36,324,062
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sox antibodi patient crohn diseas case report anti sox antibodi main associ lambert eaton myasthen syndrom letm small cell lung cancer sclc report describ interest case patient serum anti sox antibodi crohn diseas cd ensu neurolog symptom
|
D008175;D003424;D055752;D015624
|
T047;T191
|
36,324,044
|
comparison quantit semi quantit sampl methodolog biomonitor mediterranean stream use benthic macroinvertebr case studi greec greec implement water framework direct river base main benthic macroinvertebr use semi quantit method frame net certifi intern organ standard offici adopt method quantit shovel sampler cretan shovel use southern greec crete implement almost three decad due specif river habitat found crete eg season flow narrow riverb coars substrat studi compar communiti metric divers indic feed group locomot type ecolog qualiti deriv data collect use time semi quantit kick sampl quantit shovel sampl collect site simultan total sampl north south greec collect major communiti metric divers indic trait compar sampler howev statist signific differ relat abund ephemeroptera plecoptera trichoptera passiv filter semi sessil group pielou index differ ecolog qualiti kick shovel sampl observ site northern greec shovel less effect captur motil zoobentho ecolog qualiti assess crete cretan shovel compar frame net sampl thus cretan shovel could effici sampl cretan stream character coars narrow turbul hydrolog fluctuat river habitat comparison could improv sampl effect make addit data avail assess ecolog qualiti
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D045483;D007448
|
T070;T204
|
36,324,037
|
dna methylom transcriptom studi triterpenoid cddo tpa mediat skin carcinogenesi model overexposur ultraviolet radiat environment carcinogen drive skin cancer develop redox imbal gene mutat antioxid triterpenoid exhibit anti oxid anti inflammatori potenti allevi skin carcinogenesi studi investig methylom transcriptom alter tumor promot tetradecanoylphorbol acet tpa tpa cyano dioxoolean dien oic acid cddo result show cddo block tpa induc transform dose depend sever differenti express gene deg involv skin cell transform counteract cddo reveal differenti express analysi includ lyl lad denndd cpg methylom profil differenti methyl region dmrs promot region alter tpa show opposit methyl status cddo treatment group identifi correl dna methyl rna express establish dmrs show invers correl studi potenti therapeut target cpg methylom transcriptom result cddo signific restor gene express nad p h quinon oxidoreductas nqo inhibit tpa decreas promot cpg methyl ingenu pathway analysi ipa show cddo neutral effect tpa modul cell cycl cell migrat inflammatori immun respons regulatori pathway notabl tumor necrosi factor receptor tnfr signal signific downregul cddo potenti contribut prevent tpa induc cell transform overal incorpor transcriptom cpg methylom signal pathway network reveal potenti therapeut target pathway cddo could revers tpa induc carcinogenesi result could use futur human studi target develop skin cancer
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D014315;D012878
|
T191;T109
|
36,324,032
|
determin anti drug antibodi affin clinic studi sampl provid tool evalu immun respons matur character clinic anti drug antibodi ada respons biotherapeut import understand consequ immunogen ada expect polyclon composit affin evolv time measur ada bind affin complic polyclon natur respons residu drug sampl low ada level develop novel workflow determin appar ada affin k monoclon antibodi biotherapeut pf affin captur elut pre treatment step use isol ada remov residu drug interfer sampl solut phase equilibrium incub perform use drug sampl ada variabl fix bind interact respect unbound ada concentr measur use singulex erenna ligand bind assay lba method appar ada k valu calcul use custom r shini algorithm k valu determin ada posit sampl show good correl immunogen paramet includ titer neutral antibodi nab activ general increas affin time indic matur immun respons time onset high affin respons k pm vari patient rang week antibodi respons appear monophas earlier time point trend toward biphas respons variabl transit time general increas proport high affin ada time herein provid novel sensit bioanalyt method determin k ada clinic sampl observ decreas ada k consist evid matur immun respons
|
D057134;D000911
|
T129;T116
|
36,324,009
|
novel antimicrobi activ protein produc streptomyc lividan tk phytopathogen clavibact michiganensi antimicrobi protein peptid altern current antibiot report antimicrobi activ low molecular weight protein secret natur streptomyc lividan tk glucos glycerol use carbon sourc antimicrobi activ demonstr bacillus subtili bacillus cereus kokuria rhizophila clostridium sporogen clavibact michiganensi causal pathogen tomato bacteri canker one destruct bacteri diseas crop protein fraction antimicrobi activ identifi quantifi lc msms total protein found within rang kda four protein select function analysi possibl respons antimicrobi activ protein fraction correl analysi antimicrobi activ abund select protein well transcript express analysi indic ribosom protein l main candid respons antimicrobi activ
|
D008835;D018551;D000890
|
T121;T168;T007;T002
|
36,323,989
|
detect african trypanosom goat rear tsets infest villag eastern zambia control programm african anim trypanosomiasi aat livestock main focus cattl littl focus goat import reservoir diseas use polymeras chain reaction pcr studi investig trypanosom infect villag goat mambw rural district eastern zambia filter paper blood spot collect goat test infect trypanosoma congolens trypanosoma vivax trypanosoma brucei sl use ribosom rna intern transcrib spacer pcr frequenc trypanosom sampl goat ci result indic signific high infect trypanosoma vivax ci congolens ci brucei p find show circul trypanosom caus aat goat may pose serious threat goat also livestock rear alongsid goat
|
D014370;D014345;D014353;D014348;D015511
|
T047;T204
|
36,323,986
|
virtual screen repurpos approv drug target homoserin dehydrogenas paracoccidioid brasiliensi paracoccidioidomycosi system mycosi endem latin america one etiolog agent diseas paracoccidioid brasiliensi current avail treatment present advers durat side effect drug interact search new therapi possibl studi evalu drug approv use homoserin dehydrogenas enzym silico approach perform import biosynthesi phase fungus present human bodi three dimension structur homoserin dehydrogenas enzym paracoccidioid brasiliensi obtain homolog model model valid simul perform virtual screen molecul drug approv drug lib databas mtiopenscreen web server molecular dynam three replica use four drug better result two molecul control hs inhibit enzym hon show inhibit mold structur base result molecular dynam comparison bind free energi drug obtain best result bemcentinib comparison control present high relev affin kcalmol addit good structur stabil occup activ site therefor bemcentinib promis molecul inhibit pbhsd protein homoserin dehydrogenas paracoccidioid brasiliensi therapeut option investig
|
D010228
|
T004
|
36,323,953
|
overexpress vegf dermal fibroblast cell acceler angiogenesi wound heal function vitro vivo studi fibroblast main cell connect tissu pivot role prolif matur phase wound heal cell secret various cytokin growth factor collagen vascular endotheli growth factor vegf uniqu factor migrat process fibroblast cell induc wound heal cascad compon angiogenesi collagen deposit epitheli studi aim creat vegf overexpress fibroblast cell evalu angiogenesi function wound heal vitro novel recombin express vector pcdna vegf produc transfect fibroblast cell follow select fibroblast cell hygromycin recombin cell investig term vegf express quantifi qualifi method mechan physic surviv properti polyurethan cellulos acet pu ca scaffold investig final vivo angiogen potenti evalu four group contain control pu ca pu ca fibroblast cell vegf express cell day wound biopsi harvest heal process histopatholog evalu differ day qrt pcr show vegf overexpress sevenfold genet manipul cell compar fibroblast cell recombin vegf express also confirm western blot manipul fibroblast cell repres angiogenesi group second day surgeri also confirm anticd antibodi percentag wound closur area day genet manipul hu hu group show signific reduct wound area compar group find indic overexpress vegf fibroblast cell result enhanc angiogenesi format granul tissu earli stage heal process show therapeut potenti patient impair wound heal also provid function support gene therapi
|
D042461;D014945
|
T123;T040;T116
|
36,323,927
|
novel wrinkl leaf sesam mutant potenti edibl leafi veget rich nutrient sesam sesamum indicum l ancient global import oil crop tropic subtrop area apart good sourc high qualiti oil sesam also repres new sourc edibl leafi veget howev data regard nutrit composit sesam leav especi phytonutri composit scarc previous develop sesam mutant jqa cur wide thick leav potenti use veget object work gaug nutrient content leav jqa mutant colorimetri method sesam mutant jqa wild type counterpart jqb grown field leaf sampl collect flower stage result show sesam wrinkl leav jqa rich sourc crude oil crude protein amino acid mgg crude fiber cellulos hemicellulos mgg sugar mgg vitamin flavon mgg wrinkl sesam leav high unsatur acid mgg calcium mgg potassium mgg well vitamin b mgg b mgg c mgg mgg compar common green leafi veget fresh leav mean total flavon content mgg consum fresh veget preserv dri state collect nutrit composit wrinkl leaf mutant jqa ideal thus high rdis recommend daili intak suggest wrinkl leav rich sourc nutrient therefor suitabl consum new edibl green veget
|
D031685
|
T168;T002
|
36,323,913
|
parallel function annot cancer associ missens mutat histon methyltransferas use exom sequenc biomark discoveri precis medicin requir connect nucleotid level variat function chang encod protein howev function annot thousand cancer associ missens mutat variant uncertain signific vus purifi variant protein biochem function analysi cost prohibit ineffici describ parallel function annot pfa larg number vus use small cultur crude extract well plate use member histon methyltransferas famili demonstr high throughput structur function annot cancer associ mutat combin function annot paralog discov two phylogenet cluster paramet improv accuraci sequenc base function predict result demonstr valu pfa defin oncogenictumor suppressor function histon methyltransferas well enhanc accuraci sequenc base algorithm predict effect cancer associ mutat
|
D020125;D009369
|
T045;T191
|
36,323,908
|
estim solid wast generat suitabl analysi landfil site use regress geospati remot sens techniqu rangpur bangladesh municip solid wast msw manag grow problem fast develop citi consider amount solid wast generat daili dispos anywher creat unhealthi environ studi aim develop model determin household solid wast hsw generat use multipl linear regress identifi suitabl landfil site ensur proper msw dispos rangpur citi bangladesh socioeconom variabl data like averag month incom educ level famili size age famili head averag hsw generat per day collect respond stratifi random sampl confid level multi criteria decis analysi mcda perform use variabl like surfac water slope road network land use gis remot sens find suitabl landfil site result model show multicollinear varianc inflat factor estim less independ variabl furthermor model provid moder overal fit coeffici determin r denot independ variabl predict capabl result also demonstr famili size educ critic variabl predict wast generat valu coeffici respect studi also illustr suitabl landfil site mcda use resourc citi author ensur environment sustain implement effect strategi proper msw manag
|
D012037;D018505
|
T068;T057
|
36,323,906
|
new trend immunocastr potenti improv anim welfar mini review castrat frequent use reduc aggress behavior improv meat qualiti anim tradit surgic mechan castrat use steril anim approach associ high level pain stress long recoveri period post oper infect immunocastr new anim friend painless altern castrat techniqu use prevent undesir sexual behavior reduc aggress behavior prevent unwant pregnanc control wildlif popul wander speci enhanc growth perform improv meat qualiti treat various sex hormon depend disord mechan immunocastr includ immunolog block hypothalam pituitari gonad axi hpg axi inhibit gonadotropin secret caus atrophi gonad tissu inhibit gametogenesi result infertil femal male mammal mid various immunocastr vaccin test differ anim model achiev success castrat effect recent genet immunocastr especi dna vaccin gain increas attent due safeti anim friend easi use review aim evalu potenti tradit castrat method well current status immunocastr vaccin effect futur prospect
|
D000827;D014612
|
T129;T121;T116;T053;T052
|
36,323,877
|
identif candid gene associ resist race colletotrichum lenti len ervoid resist anthracnos caus fungal pathogen colletotrichum lenti explor transcriptom sequenc period h post inocul hpi partial resist recombin inbr line ril lr suscept lr crop wild relat len ervoid popul lr develop infect vesicl primari hypha c lenti signific higher suscept ril lr compar partial resist lr hpi exponenti trend fungal growth observ hpi ril comparison inocul mock inocul sampl reveal diseas respons gene among differenti express two ril cluster six express cluster gene either high low express one ril differenti express gene deg function annot includ gene code lrr nb arc domain diseas resist protein protein detoxif lrr receptor like kinas famili protein wall associ serthr kinas deg compar gene previous publish anthracnos resist qtls map lr reveal deg locat qtls express deg valid use rt qpcr confirm express trend rna seq
|
D020231;D007887
|
T004;T002
|
36,323,871
|
estim genom herit genom wide associ studi blood paramet akkaraman sheep aim studi estim genom herit impact genet background blood paramet akkaraman sheep conduct genom wide associ studi region herit map analysi genom herit estim blood paramet rang indic measur phenotyp low moder herit total genom chromosom wide signific snps associ phenotyp chang blood paramet test accord scna scna myadm like ccdc itga mgat slca amph ntrk msra slcf sirt crebl nav gene well three undefin region loc loc loc suggest candid identifi gene involv basic biolog process essenti immun system function cellular growth specif function includ cellular transport histon deacetyl cell differenti erythropoiesi endocytosi top signific snp hct mch mchc found within genom region main popul myadm like gene famili region previous suggest histor select pressur mani sheep breed various part world result implic anim breed program studi due effect genet background blood paramet under mani product well relat trait
|
D055106;D016678
|
T063;T028
|
36,323,869
|
long term microglia deplet impair synaps elimin auditori brainstem function special sound local circuit develop requir synaps strengthen refin prune mani function carri microglia immun cell aid regul neurogenesi synaptogenesi apoptosi synapt remov previous show postnat treatment blz blz inhibitor coloni stimul factor receptor csfr elimin microglia brainstem disabl calyc prune matur astrocyt medial nucleus trapezoid bodi mntb blz treatment result elev hear threshold delay signal propag measur auditori brainstem respons abr howev microglia repopul brain follow cessat blz deficit repair unknown whether recoveri achiev without return microglia induc sustain microgli elimin two drug approach use blz plx plx found blzplx treat mice impair calyc prune diminish astrocyt gfap later low frequenc region mntb elev glycin transport glyt level blzplx treat mice elev hear threshold diminish peak amplitud alter latenc inter peak latenc find suggest microglia requir repopul brain order rectifi deficit ablat
|
D017628;D065833
|
T023;T025
|
36,323,868
|
preliminari result indic regular train induc high protect oxid stress basketbal player compar soccer elit athlet sever metabol chang occur regular train modif associ chang blood metabol profil lead adapt mechan aim establish new dynam equilibrium guarante better perform goal studi character plasma metabol profil redox homeostasi athlet practic two differ team sport soccer basketbal order identifi potenti metabol pathway under differ train program cohort male profession player soccer basketbal sedentari male control enrol studi plasma redox balanc metabolit adiponectin determin result show low level oxid speci high antioxid capac adiponectin level plasma basketbal player comparison soccer player metabol analysi indic basketbal player signific high plasma level amino acid valin ornithin involv redox homeostasi anti inflammatori metabol
|
D001490;D012916
|
T056;T073
|
36,323,867
|
investig spermathec morpholog reproduct strategi fate store spermatozoa three import thysanopteran speci insect femal keep sperm capabl fertilis long period help spermatheca effect store fertil sperm expect reflect reproduct strategi thus morpholog involv organ work focus relationship reproduct morpholog haplodiploid thysanoptera especi loss trait occur thelytoki spermathec morpholog fate store spermatozoa studi microscop techniqu high resolut x ray comput tomographi transmiss electron microscopi three speci differ reproduct mode lifestyl suocerathrip lingui echinothrip americanus hercinothrip femorali mate experi conduct analys use transfer sperm thelytok h femorali result show spermatheca relat simpl explain avail sperm short lifespan femal howev spermatheca h femorali seem vestigi compar arrhenotok speci femal use sperm fertilis substanti chang observ structur spermatozoa despit enlarg sperm organell measur storag three speci result work demonstr differ morpholog spermatheca especi concern reproduct mode promot understand complex interact morpholog behaviour
|
D012661;D013094
|
T025;T031
|
36,323,864
|
postharvest treatment mncl zncl reduc enzymat brown enhanc antioxid accumul soya bean sprout soya bean sprout nutrient abund veget howev enzymat brown soya bean sprout storag remain challeng studi effect treatment mncl zncl brown index antioxid nutrient accumul total antioxid capac enzym activ phenylalanin ammonia lyas pal polyphenol oxidas ppo peroxidas pod superoxid dismutas sod catalas cat investig soya bean sprout storag c relat humid day result show postharvest treatment mm mncl zncl profound retard enzymat brown soya bean sprout differ extent compar control mm mncl zncl treatment drastic enhanc ascorb acid total thiol phenol content enhanc frap ferric reduc abil plasma antioxid capac store soya bean sprout moreov mncl zncl treatment enhanc sod cat pal decreas ppo pod activ compar control addit mn zn content soya bean sprout signific increas approxim two threefold compar control studi provid new method improv nutrient qualiti soya bean sprout base postharvest mn zn supplement
|
D000975;D004156
|
T123;T121;T116;T126;T039;T044
|
36,323,863
|
specimen mammographi intraop margin assess breast conserv surgeri meta analysi breast conserv surgeri bcs specimen mammographi one wide use intraop method assess margin status perform meta analysi evalu diagnost accuraci specimen mammographi literatur databas includ pubm cochran librari web scienc embas search prior jun total patient includ studi pool analysi heterogen test threshold effect test public bias analysi subgroup analys perform extract data pool weight valu sensit confid interv ci specif ci diagnost odd ratio ci pool posit likelihood ratio ci area receiv oper characterist curv ci subgroup analysi pool specif posit margin defin tumor margin subgroup lower posit margin definit subgroup ci vs ci p find indic specimen mammographi accur intraop imag techniqu margin assess bcs
|
D009369;D001943
|
T191
|
36,323,861
|
airborn ultrasound puls amplif base acoust reson switch airborn ultrasound radiat pressur nonlinear effect appear static forc mid air presenc strong ultrasound recent appli novel scientif industri field howev output power ultrasound transduc remain low main due signific mismatch acoust imped solid diaphragm air circumv fundament challeng propos emit amplifi airborn ultrasound puls instantan releas store acoust energi free space specif implement acoust caviti mechan rotat shutter cover open top acoust caviti fulli charg store energi releas open shutter develop choke structur reduc leakag store energi generat ultrasound puls time higher peak power input continu wave khz preliminari result great potenti generat high power ultrasound puls use convent air coupl transduc separ storag radiat process thus circumv fundament limit brought imped mismatch
|
D000162;D014159
|
T070;T074
|
36,323,859
|
nucleat cadherin cluster cell cell interfac cadherin mediat cell cell adhes help cell determin shape function studi collect cadherin organ interact within cell cell contact area find cadherin densiti gas liquid phase transit occur cadherin monom begin aggreg dens cluster use lattic model cell cell contact area coars grain continu number densiti cadherin map model onto cahn hilliard coarsen theori predict densiti requir nucleat characterist length scale process number densiti cluster analyt predict model good agreement experiment observ cadherin cluster epitheli tissu
|
D015820
|
T123;T116
|
36,323,848
|
multiplex base edit casa variant mediat cytosin adenin base editor casa process multipl sgrnas singl transcript crispr array confer advantag multiplex base edit incorpor base editor system extrem help given phenotyp common involv multipl gene singl nucleotid variant howev multiplex base edit casa deriv base editor bare report main due compromis effici restrict protospac adjac motif pam tttv wild type casa develop casa mediat cytosin base editor cbe adenin base editor abe system elev effici expand target scope combin high activ deaminas lachnospiracea bacterium casa lbcasa variant confirm cbes abe perform effici c g convers respect target pam nttn tycn trtn notabl multiplex base edit conduct use develop cbes abe somat cell embryo casa variant mediat base editor serv versatil tool multiplex point mutat notabl import genet improv diseas model gene therapi
|
D000072669;D064113
|
T063;T040
|
36,323,845
|
scene relat object motion bias depth percept import function visual system repres scene structur sequenc imag project onto retina observ translat relat imag motion stationari object differ distanc motion parallax provid potent depth inform howev object move relat scene complic comput depth motion parallax sinc addit compon imag motion relat scene relat object motion correct comput depth motion parallax compon imag motion caus self motion use brain previous experiment theoret work percept depth motion parallax assum object stationari world thus unknown whether perceiv depth base motion parallax bias object motion relat scene nave human subject view virtual scene consist ground plane stationari background object later self motion simul optic flow target object could either stationari move later differ veloc subject ask judg depth object relat plane fixat subject show far bias object observ move direct near bias object observ move opposit direct pattern bias expect subject confound imag motion due self motion due scene relat object motion bias larg object view monocular great reduc elimin binocular dispar cue provid find establish scene relat object motion confound perceptu judgement depth self motion
|
D009039;D057849
|
T040;T041
|
36,323,842
|
estim hospit visit respiratori diseas attribut pm veget fire smoke health impact regulatori intervent upper northern thailand air qualiti upper northern thailand unt deterior season veget fire event caus advers effect especi respiratori health outcom studi aim quantit estim respiratori morbid veget fire smoke exposur assess impact burn ban enforc morbid burden unt comput daili popul exposur fire origin pm estim health burden year period use daili fire origin pm concentr concentr respons function short term exposur pm veget fire smoke respiratori morbid subgroup classifi children older adult health burden respiratori morbid estim use specif effect coeffici previous studi conduct unt final compar health burden respiratori morbid burn ban enforc approxim hospit visit respiratori diseas estim attribut fire origin pm unt estim account total hospit visit respiratori diseas year period burn event age specif estim reveal larger impact pm older adult group number hospit visit respiratori diseas attribut fire origin pm decreas burn ban polici implement area find suggest pm releas veget fire health burden unt prohibit burn use regulatori measur posit impact respiratori morbid area
|
D000397;D005390;D000393
|
T131;T069;T067;T080
|
36,323,841
|
microrna target phosphomevalon kinas inhibit cancer cell growth via mevalon pathway microrna mir mir potenti tumour suppressor caus cell death via target gene suppress various cancer type mevalon pathway inhibit also caus cell death breast cancer howev relationship mevalon pathway mir induc apoptosi associ tumour suppressor p elucid identifi phosphomevalon kinas pmvk key mevalon pathway enzym sterol regulatori element bind factor srebf master cholesterol biosynthesi regul direct mir target next generat sequenc analysi reveal signific mir mediat downregul pmvk srebf gene express p pathway enrich luciferas report assay show mir direct regul pmvk srebf mir induc apoptosi p depend singl cell rna sequenc analysi demonstr mir transfect result apoptosi p pathway activ downregul pmvk express also caus cell cycl arrest p pathway activ rescu geranylgeranyl pyrophosph ggpp supplement analysi cancer genom atlas tcga databas indic negat correl mir pmvk express mir srebf express find suggest mir suppress mevalon pathway target srebf pmvk result ggpp deplet activ p pathway promot cycl arrest apoptosi
|
D016159;D035683
|
T123;T116;T114
|
36,323,840
|
chemic composit heartwood sapwood tectona grandi character cgms py teak wood chemic compound use pharmaceut textil industri addit compound relat resist biodeterior color modif process heartwood sapwood grandi teak year old character py cgms analysi syringyl guaiacyl g ratio evalu heartwood sapwood pyrolyz c compound identifi respect acet acid levoglucosan abund compound sapwood heartwood respect high acet acid content enhanc use teak wood product artifici essenc perfumeri paint dye levoglucosan use manufactur epoxi resin antiparasit insecticid organ compound identifi includ methylanthraquinon one main compon respons resist teak wood biolog factor fungi termit syringyl guaiacyl g ratio heartwood sapwood respect
|
D019686
|
T002
|
36,323,818
|
characterist outcom sever covid hospit patient cardiovascular diseas amazonian region brazil retrospect cohort northern region brazil alreadi vulner infecti diseas differ covid howev cardiovascular diseas still lead caus death thus object studi identifi clinic predictor outcom sever covid hospit patient without cvd region amazon retrospect cohort refer notif januari decemb includ case confirm molecular test studi consist confirm case covid cardiovascular diseas cardiovascular diseas signific death age group cvd carrier predictor mortal invas ventil patient cvd ci follow chronic kidney diseas ci dyspnea ci respiratori distress ci cough ci lower oxygen satur ci diabet mellitus ci age ci carrier cvd lower surviv rate order predictor death differ among non carrier well high odd ratio predictor cvd cough independ predictor age group year associ death also show shorter surviv cvd carrier well higher cardiovascular morbid rate studi literatur
|
D000086382;D002318
|
T047;T067
|
36,323,817
|
wireless neuromodul vitro vivo intrins trpc mediat magnetomechan stimul various magnet deep brain stimul dbs method develop rapid last decad minim invas dbs howev current magnet dbs method magnetotherm magnetomechan stimul requir overexpress exogen ion channel central nervous system cns unclear whether magnetomechan stimul modul non transgen cns neuron reveal torqu magnet nanodisc weak slow altern magnet field mt hz could activ neuron intrins transient receptor potenti canon channel trpc mechanosensit ion channel wide express brain immunostain c fos show increas neuron activ wireless dbs magnetomechan approach vivo overal research demonstr magnet nanodisc base magnetomechan approach use wireless neuron stimul vitro unteth dbs vivo without implant genet manipul
|
D046690;D050051
|
T061;T123;T116
|
36,323,816
|
extrem temperatur increas risk stillbirth third trimest pregnanc epidemiolog studi report associ extrem temperatur advers reproduct effect howev suscept period exposur pregnanc remain unclear studi aim assess impact extrem temperatur stillbirth rate perform time seri analysi explor associ temperatur stillbirth distribut lag nonlinear model total stillbirth taiwan enrol mean stillbirth rate per birth relat risk stillbirth due exposur extrem heat temperatur c ci pregnant women third trimest suscept effect extrem cold heat temperatur lag month cumul relat risk crr stillbirth exposur extrem heat temperatur c th percentil temperatur relat optim temperatur c ci crr stillbirth exposur extrem low temperatur c st percentil ci stillbirth rate taiwan rise find inform public health intervent manag health impact climat chang
|
D050497;D055874
|
T033
|
36,323,809
|
volcan trigger ocean deoxygen cordilleran ice sheet retreat north pacif deoxygen event last deglaci sustain millennia high export product trigger mechan link deglaci warm remain uncertain find initi deoxygen north pacif immedi cordilleran ice sheet cis retreat associ increas volcan ash seafloor sediment time volcan input relat cis retreat suggest region explos volcan initi ice unload posit iron fertil volcan ash cis retreat fuell ocean product otherwis iron limit region tip marin system toward sustain deoxygen also identifi older deoxygen event link cis retreat past approxim year ref find suggest appar coupl atmospher ocean cryospher solid earth system occur relat short timescal act import driver ocean biogeochem chang
|
D046448;D009792;D010100;D012623;D018707
|
T121;T123;T070;T131;T083;T196;T167
|
36,323,805
|
prodigiosin inhibit prolifer glioblastoma regul kiaappa signal pathway prodigiosin pg member famili natur red pigment produc varieti bacteria first discov serratia marcescen pg report apoptosi induc effect mani cancer lymphoma colon cancer nasopharyng carcinoma studi use three glioblastoma gbm cell line ln u explor effect prodigiosin gbm cell cck assay use evalu cell viabil determinedth cell cycl distribut flow cytometri measur prolifer edu incorpor assay express differ molecul investig western blot rt pcr confirm result plasmid transfect lentivir transduct ln xenograft model use studi effect prodigiosin vivo confirm prodigiosin play anticanc role sever gbm cell line kiaappaakt signal pathway prodigiosin inhibit protein express kiaa suppress transcript led activ ppa afterward ppa inhibit phosphoryl akt therebi induc increas express pp furthermor verifi prodigiosin inhibit kiaappaakt axi vivo ln xenograft model data improv understand anticanc effect prodigiosin highlight potenti prodigiosin develop anti glioma drug
|
D005909;D011353
|
T121;T191;T130;T109
|
36,323,802
|
dual view multi resolut laparoscop safer effici minim invas surgeri minim invas surgeri mis limit safeti effici hand held natur narrow field view tradit laparoscop multi resolut foveat laparoscop mrfl invent address concern mrfl stationari dual view imag devic optic pan zoom capabl design simultan captur display zoom view supplement wide view surgic field optic zoom pan capabl facilit reposit zoom view without physic move system addit mrfl featur design improv safeti effici includ snub nose endoscop tool tip auto track programm focus profil uniqu select display modal foot pedal control independ control surgeon assist display mrfl prototyp construct demonstr test featur test prototyp valid design architectur confirm function featur current mrfl prototyp function adequ proof concept system featur perform requir improv practic clinic use
|
D020706;D066231
|
T074;T097
|
36,323,801
|
novel cuproptosi relat immun checkpoint gene signatur identif experiment valid hepatocellular carcinoma copper induc death also term cuproptosi novel form program cell death promis new strategi cancer therapeut elev copper level tumor cell posit associ high pd l express nonetheless prognost signific cuproptosi relat immun checkpoint gene cricg hepatocellular carcinoma remain clarifi studi aim construct prognost cricg signatur predict immunotherapi respons outcom hcc patient co express cricg first screen pearson correl analysi base least absolut shrinkag select oper cox regress analys identifi prognost cricg model close correl poor outcom cancer develop immun respons hepatocellular carcinoma extern valid conduct use gse dataset last qrt pcr perform determin express cricg hcc summari develop valid novel prognost cricg model base cricg prognost signatur could effect forecast outcom immun respons hcc patient may serv biomark anticanc therapi
|
D006528;D008113
|
T191
|
36,323,798
|
molecular character elucid function hap mapk respons helicoverpa armigera hbner uv stress cotton bollworm helicoverpa armigera hbner lepidoptera noctuida import pest cotton detriment cotton product light uv ultraviolet lamp regard form environment stress insect order investig respons h armigera expos uv explor hap mapk express function hope find studi lay foundat futur investig insect phototaxi mechan p mapk clone name hap mapk phylogenet tree show hap mapk high conserv gene high express thorax femal uv stress express gene decreas signific silenc hap mapk activ antioxid enzym sod pod cat gr decreas studi suggest hap mapk respond uv irradi play critic role defens respons environment stress
|
D009036
|
T204
|
36,323,794
|
identif queen primer pheromon higher termit long establish queen social insect includ termit maintain reproduct domin queen primer pheromon qpps yet qpp chemistri elucid singl speci lower termit contrast diversifi termit famili termitida higher termit compris termit speci far resist attempt qpp identif show queen egg specif sesquiterpen nerolidol act qpp higher termit embiraterm neotenicus speci polygyn breed system primari queen replac multipl neoten queen parthenogenet origin demonstr nerolidol suppress develop parthenogenet queen thus mimic presenc matur queen act airborn signal may use optim number queen thus key regulatori element special breed system e neotenicus
|
D020049;D012717
|
T204;T109
|
36,323,793
|
improv aerodynam behaviour passeng car use combin ditch base bleed current studi investig differ method minim drag coeffici c without ignor safeti factor relat stabil vehicl ie lift coeffici c l studi carri employ suv car analyz numer use one cfd softwar ansi four differ model realiz k standard k shear stress transport k reynold stress model rsm consid model valid experiment data found good agreement consid inlet veloc vari ms result show drag coeffici stabil improv appli modif roof consid car
|
D001336;D012984
|
T090;T170;T073
|
36,323,790
|
self supervis machin learn live cell imageri segment segment singl cell necessari process extract quantit data biolog microscopi imageri past decad seen advent machin learn ml method aid process overwhelm major fall supervis learn sl requir vast librari pre process human annot label train ml algorithm sl pre process labor intens introduc bias vari end user yet shown capabl robust model effect util throughout greater cell biolog communiti address pre process problem offer self supervis learn ssl approach util cellular motion consecut imag self train ml classifi enabl cell background segment without need adjust paramet curat imageri leverag motion achiev accur segment train direct end user data independ optic modal outperform contemporari sl method complet autom fashion thus elimin end user variabl bias best knowledg ssl algorithm repres first kind effort appeal featur make ideal segment tool candid broader cell biolog research communiti
|
D000069553;D000465
|
T170;T066
|
36,323,789
|
data driven comorbid analysi common disord reveal patient subgroup differ mortal risk laboratori correl popul heterogen diseas part due comorbid pose sever complex individu comorbid profil hand contain use inform refin phenotyp prognost risk assess provid clue under biolog nevertheless spectrum implic diagnosi profil remain larg unchart map comorbid pattern common diseas use year retrospect data patient develop onlin tool visual result analysi expos diseas specif patient subgroup distinct diagnosi pattern surviv function laboratori correl comput model real world data shed light structur variat relev popul comorbid pattern pave way improv diagnost risk assess individu care variat outcom biolog correl diseas emphas import evalu generaliz current treatment strategi well consid limit select inclus criteria pose clinic trial
|
D012189
|
T062
|
36,323,784
|
block pd l pd improv senesc surveil age phenotyp accumul senesc cell major caus age relat inflamm predispos varieti age relat diseas howev littl known molecular basi under accumul potenti target amelior age process show senesc cell heterogen express immun checkpoint protein program death ligand pd l pd l senesc cell accumul age vivo pd l cell sensit cell surveil wherea pd l cell resist even presenc senesc associ secretori phenotyp sasp singl cell analysi p cell vivo reveal pd l express correl higher level sasp consist administr program cell death protein pd antibodi natur age mice mous model normal liver induc nonalcohol steatohepat reduc total number p cell vivo well pd l popul activ cd cell depend manner amelior various age relat phenotyp result suggest heterogen express pd l import role accumul senesc cell inflamm associ age elimin pd l senesc cell immun checkpoint blockad may promis strategi anti age therapi
|
D060890;D061026
|
T129;T116;T192
|
36,323,783
|
extracellular fluid viscos enhanc cell migrat cancer dissemin cell respond physic stimuli stiff fluid shear stress hydraul pressur extracellular fluid viscos key physic cue vari physiolog patholog condit cancer howev influenc cancer biolog mechan cell sens respond chang viscos unknown demonstr elev viscos counterintuit increas motil various cell type two dimension surfac confin increas cell dissemin three dimension tumour spheroid increas mechan load impos elev viscos induc actin relat protein arp complex depend dens actin network enhanc na h exchang nhe polar actin bind partner ezrin nhe promot cell swell increas membran tension turn activ transient receptor potenti cation vanilloid trpv mediat calcium influx lead increas rhoa depend cell contractil coordin action actin remodellingdynam nhe mediat swell rhoa base contractil facilit enhanc motil elev viscos breast cancer cell pre expos elev viscos acquir trpv depend mechan memori transcript control hippo pathway lead increas migrat zebrafish extravas chick embryo lung colon mice cumul extracellular viscos physic cue regul short long term cellular process pathophysiolog relev cancer biolog
|
D000199;D009369
|
T123;T191;T116
|
36,323,780
|
nociceptor neuron affect cancer immunosurveil solid tumour innerv nerv fibr aris autonom sensori peripher nervous system whether neo innerv tumour pain initi sensori neuron affect cancer immunosurveil remain unclear show melanoma cell interact nociceptor neuron lead increas neurit outgrowth respons noxious ligand neuropeptid releas calcitonin gene relat peptid cgrp one nociceptor produc neuropeptid direct increas exhaust cytotox cd cell limit capac elimin melanoma genet ablat trpv lineag local pharmacolog silenc nociceptor antagon cgrp receptor ramp reduc exhaust tumour infiltr leukocyt decreas growth tumour near tripl surviv rate mice inocul bf melanoma cell convers cd cell exhaust rescu sensori neuron deplet mice treat local recombin cgrp compar wild type cd cell ramp cd cell protect exhaust co transplant tumour bear rag defici mice singl cell rna sequenc biopsi patient melanoma reveal intratumor ramp express cd cell exhaust ramp negat counterpart wherea overexpress ramp correl poorer clinic prognosi overal result suggest reduc releas cgrp tumour innerv nociceptor could strategi improv anti tumour immun elimin immunomodulatori effect cgrp cytotox cd cell
|
D009619;D008545
|
T023;T191
|
36,323,777
|
light competit drive herbivor nutrient effect plant divers enrich nutrient loss herbivor assum caus loss plant divers grassland ecosystem increas plant cover lead decreas light understori empir test role competit light natur system base indirect evid topic debat last year show experiment restor light understori plant natur grassland mitig loss plant divers caus either nutrient enrich absenc mammalian herbivor initi effect light addit restor divers fertil transitori outweigh greater effect herbivori light level indic herbivori major factor control divers part light result provid direct experiment evid natur system competit light key mechan contribut loss biodivers cessat mammalian herbivori find also show effect herbivor outpac effect fertil competit light manag practic target maintain graze nativ domest herbivor could therefor applic protect biodivers grassland ecosystem allevi competit light understori
|
D060434;D017753
|
T070;T040;T008;T082
|
36,323,775
|
instantan micro particl imag velocimetri piv via multifoc microscopi mum multifoc microscopi mum techniqu captur multipl field view fov distinct axial plane simultan one camera use perform micro particl imag velocimetri piv reconstruct veloc shear stress field impos liquid flow around cell diffract base multifoc relay use captur imag three differ plane nm axial space axial posit flow trace particl calcul use imag sharp metric shown mum achiev accuraci calcul veloc around ms use fix cell mum imag flow perturb sub cellular level show characterist similar observ literatur use live cell exemplar mum observ effect chang cell morpholog local flow perfus compar standard confoc laser scan microscop mum offer clear advantag acquisit speed piv time faster import characterist rapid evolv biolog system necess monitor real time entir volum correl sampl respons extern forc
|
D012212
|
T059;T057
|
36,323,773
|
blib multi modul simul platform genet studi intellig breed simul effici approach investig theoret appli issu popul quantit genet anim plant breed studi report multi modul simul platform call blib abl handl complic genet effect model exist tool two deriv data type first defin blib one hold requir inform genet model one repres genet breed popul number subroutin develop perform specif task four case studi present exampl show applic blib ie genet drift multipl allel random mate popul joint effect neutral mutat genet drift comparison mass versus famili select choic tester hybrid breed blib togeth applic modul great potenti benefit theoret genet studi intellig breed simul predict outcom larg number scenario identifi best optimum select cross scheme
|
D012641;D012098
|
T070;T040;T045;T079;T081
|
36,323,772
|
ultrasound perform use eu tirad score diagnosi thyroid cancer congoles hospit thyroid imag report data system european thyroid associ eu tirad wide use malign risk stratif thyroid nodul howev pauciti data develop countri especi africa valid use score system aim studi assess diagnost valu eu tirad score congoles hospit use patholog examin surgeri gold standard congoles hospit retrospect analyt studi examin clinic ultrasound patholog data patient age year includ femal oper thyroid nodul januari januari present studi highest grade nodul accord eu tirad score patient taken account statist analys nodul consid nodul classifi eu tirad one hand hand consid respect low high risk malign sensit specif eu tirad score calcul signific level set patient malign nodul made nodul patient younger year old age malign nodul frequent men women vs p papillari carcinoma follicular carcinoma main type malign rate among nodul rate eu tirad eu tirad score respect p eu tirad score sensit specif roc curv indic area curv low incom countri well perform thyroid ultrasound use eu tirad score could import tool select thyroid nodul suspect malign requir histopatholog examin congoles hospit settingtri registr research protocol obtain favor opinion drc nation health ethic committe cnesbnpmmf data collect analyz anonym
|
D016606;D013964
|
T191
|
36,323,771
|
automat pseudo color approach improv visual percept contrast polarimetr imag biolog tissu imag polarimetri method prove suitabl enhanc imag contrast tissu structur organ sampl even reveal structur hidden regular intens imag method nowaday use wide rang biolog applic earli diagnosi differ patholog includ discriminatori potenti differ polarimetr observ singl imag suitabl strategi report literatur consist associ differ observ differ color channel give rise pseudo color imag help visual differ tissu sampl howev previous report polarimetr base pseudo color imag tissu most base simpl linear combin polarimetr observ whose weight set ad hoc thus far optim approach framework propos implement two pseudo color method one base euclidean distanc actual valu pixel averag valu taken given region interest consid imag second method base likelihood pixel belong given class class defin basi statist model describ statist distribut valu pixel consid imag method experiment valid four differ biolog sampl two anim origin two veget origin result provid potenti method appli biomed botan applic
|
D015233;D014796
|
T081;T170;T041
|
36,323,770
|
discoveri sar cov antivir synergi remdesivir approv drug human lung cell sar coronavirus sar cov caus ongo global pandem signific mortal morbid time fda approv therapeut covid remdesivir broad spectrum antivir nucleosid analog efficaci moder improv treatment strategi urgent need accomplish goal devis strategi identifi compound act synergist remdesivir prevent sar cov replic conduct combinatori high throughput screen presenc submaxim remdesivir concentr use human lung epitheli cell line infect clinic isol sar cov identifi approv drug act synergist remdesivir mani favor pharmacokinet safeti profil strongest effect observ establish antivir hepat c virus nonstructur protein hcv nsa inhibitor velpatasvir elbasvir combin partner drug sofosbuvir grazoprevir increas efficaci increas remdesivir appar potenc fold report hcv nsa inhibitor act sar cov exonucleas proofread provid possibl explan synergi observ nucleosid analog remdesivir fda approv hepat c therapeut epclusa velpatasvirsofosbuvir zepati elbasvirgrazoprevir could optim achiev potenc pharmacokinet properti support clinic evalu combin remdesivir
|
D000086382;D006526
|
T047;T067
|
36,323,767
|
root paramet sugarcan soil compact indic deep strip tillag convent tillag soil tillag agricultur traffic generat chang soil physic attribut affect growth root studi evalu impact system soil tillag compact sugarcan root growth experi carri rhodic kandiudox two soil tillag deep strip tillag convent tillag two posit bed traffic lane traffic lane total four treatment dst bed traffic lane dst traffic lane ct traffic lane ct traffic lane soil penetr resist spr bulk densiti dri mass root system length volum evalu dst bed present lower valu spr mpa compar treatment mpa lower spr reflect signific increas root growth relat dst traffic lane mean root confin bed dri root mass ct traffic lane less dst traffic lane ct traffic lane reduc root dri mass layer respect compar dst bed therefor ct although wide use creat adequ condit root develop first sugarcan cycl even lane traffic
|
D012987;D031786
|
T002;T167
|
36,323,766
|
age deposit depth sediment report biped footprint trachilo nw crete greec new data foraminif region geolog set trachilo sediment nw crete greec gierlinski et al proc geol assoc describ hominin like footprint show publish shallow marin interpret incorrect new interpret trachilo success late pliocen part shallow marin seri becam subaeri expos million year ago place larger geolog context crete island late pliocen separ km open sea nearest european mainland therefor reach late pliocen hominin
|
D015186
|
T015
|
36,323,764
|
optim oviposit trap set monitor popul aed mosquito vector arbovirus la reunion sever dengu epidem recent occur la reunion island harbor two dengu virus dvs vector aed albopictus ae aegypti former main local dv vector aed aegypti show peculiar ecolog compar tropic popul speci studi aim provid research public health user local valid oviposit trap ovitrap monitor aed popul field experi perform saint joseph assess effect differ set detect probabl appar densiti aed mosquito black plastic ovitrap identifi best choic vacoa tree pandanus utili observ breed site ae aegypti share ae albopictus experiment unit latin squar design three factor trap posit tree ground vs canopi oviposit surfac trap blot paper vs vacoa leaf addit organ matter trap water latter factor found unimport ground ae aegypti egg found vacoa leav oviposit surfac detect appar densiti increas ovitrap locat tree canopi main factor ae albopictus oviposit surfac prefer blot paper trap set detect close larval surviv lower high egg densiti combin blot paper oviposit surfac monitor mix aed popul la reunion recommend use black plastic ovitrap place high vacoa tree vacoa leav oviposit surfac
|
D000330;D001103
|
T005;T204
|
36,323,763
|
posit effect inaud high frequenc compon sound glucos toler quasi experiment crossov studi although stress signific impact various metabol syndrom includ diabet mellitus stress manag techniqu base psycholog subject approach studi examin presenc absenc inaud high frequenc compon hfc sound activ deep brain structur affect glucos toler healthi particip use oral glucos toler test ogtt sound contain hfc suppress increas glucos level measur increment area curv ogtt compar otherwis sound without hfc suppress effect hfc promin older age group group high hbac suggest sound hfc effect improv glucos toler individu higher risk glucos intoler
|
D018149;D003920;D003924
|
T047
|
36,323,761
|
impact hounsfield unit relat variabl percutan nephrolithotomi outcom aim identifi associ hounsfield unit hu relat variabl percutan nephrolithotomi pcnl outcom enrol patient singl renal stone cm underw singl tract pcnl januari octob demograph stone characterist retrospect review preoper computer tomographi ct follow ct within least month pcnl includ analysi stone free status defin residu stone measur mm within month postop hu cross section area csa measur use free draw techniqu analyz hu relat variabl use logist regress model outcom altogeth patient met inclus criteria stone free rate sfr signific differ age sex bmi asa class later pre op shockwav lithotripsi stone size stone burden skin stone distanc hu stone free remnant group csa hucsa stone free remnant group p p respect multivari logist regress analysi reveal pelvi ureteropelv junction stone hucsa independ predictor sfr hu affect pcnl outcom believ hucsa could use determin stone treatment plan predict outcom
|
D000074642;D008096;D007669
|
T061;T047
|
36,323,760
|
studi relationship odor hedon rate individu odor detect threshold odor hedon percept pleasantunpleas charact consid first one promin dimens olfact known depend sever paramet among relat odor concentr hedon estim wide studi howev studi consid odor hedon rate ohr relat individu detect threshold idt thus aim studi determin olfactori detect threshold describ hedon rate variat individu threshold higher concentr idt perform two pleasant appl jasmin two unpleas durian trimethylamin odor stimuli experiment present one one random order differ odor concentr idt particip rate odor hedon valenc stimuli visual analog scale result show except trimethylamin relationship hedon rate stimulus concentr ie increas pleasant appl jasmin unpleas durian rate low middl concentr follow plateau high concentr correl ohr concentr well ohr threshold step alway signific moreov comparison condit show correl coeffici signific higher trimethylamin trend appl idt consid differ found jasmin durian overal result suggest relationship ohr idt odor specif find contribut explain larg variabl hedon tone ie weak vs pleasant weak vs unpleas specif concentr general popul could serv futur research field eg olfactori prefer nutrit studi anhedonia psychiatr disord
|
D009812;D031660
|
T120;T070;T002
|
36,323,758
|
strategi protect area use asian eleph relat motiv state social affili anim space requir may vari accord life histori social consider observ wild adult asian eleph sex year investig life histori trait social behavior influenc protect area pa use udawalaw nation park sri lanka male pa use quantifi term averag sight interv bsi signific influenc interact age class motiv state ie reproduct vs forag musth lengthen age median day age day age day minor use exclus musth other use exclus forag male use state older musth male like seen across year social communiti contain adult femal femal bsi signific influenc social tie relationship weak member social communiti necessarili dispers togeth result high individu variat space use inter annual variabl sight among individu sex indic around popul like non residenti across year challeng prevail fortress conserv paradigm wildlif manag
|
D004606
|
T015
|
36,323,756
|
identif two qtls bph bph respect gene candid brown planthopp resist rice brown planthopp bph lead caus insect damag rice plant bph infest caus profound loss rice product sinc urgent need discov new bph resist gene ensur success product rice new bph resist sourc provid seedwork intern pvt ltd swd use purpos qtl map use f progeni polymorph marker reveal two domin bph resist qtls bph bph locat chromosom bph resist mechan test reveal antibiosi antixenosi mechan play role bph resist confer two qtls qtls delimit marker swrm swrm bph swrm swrm bph addit use rna seq data line contain resist qtls shortlist four three gene candid bph bph respect differenti gene express analysi line contain qtls suggest swd bph resist contribut plant innat immun candid gene may part rice innat immun pathway current newli identifi qtls util breed bph resist rice varieti hybrid
|
D006430;D012275;D011470
|
T168;T191;T204;T047;T002
|
36,323,754
|
taxonom respons bacteri fungal popul biofertil appli soil substrat greenhous grown cucumb reduct qualiti yield crop continu produc locat mani year due annual increas soil born pathogen environment friend method need produc veget sustain cost effect protect cover investig impact biofertil cucumb growth yield chang popul soil microorgan respons biofertil treatment appli substrat soil observ biofertil signific increas cucumb growth decreas soil born pathogen soil substrat rhizospher microbi communiti soil substrat respond differ differ biofertil also led signific differ microbi divers taxonom structur differ time grow season biofertil increas prospect use substrat continu produc high qualiti crop cost effect soil year time control soil born diseas
|
D012987;D018553
|
T168;T002;T167
|
36,323,753
|
insight qualiti recombin protein produc two differ bombyx mori express system silkworm bombyx mori attract host recombin protein product due high express effici qualiti quantiti two express system wide use recombin protein product b mori baculovirussilkworm express system transgen silkworm express system express system enabl high protein product qualiti result recombin protein well evalu studi express bovin interferon ifn use two system examin qualiti result protein term n glycosyl protein cleavag express system success produc ifn n glycoprotein although product baculovirussilkworm express system much effici transgen silkworm express system unexpect variant ifn also produc former system due differ n glycosyl c termin truncat result indic high protein product could achiev baculovirussilkworm express system unintent protein modif might occur therefor protein express transgen silkworm express system prefer point view n glycosyl recombin protein evas unexpect attack proteas b mori
|
D012831
|
T204
|
36,323,752
|
neuroprotect metabolit via fungal biotransform novel sapogenin cyclocephagenol cyclocephagenol novel cycloartan type sapogenin tetrahydropyran unit encount astragalus speci rare sapogenin never topic biolog activ modif studi object studi perform microbi transform studi cyclocephagenol use astragalus endophyt alternaria eureka ebl follow isol structur character metabolit ii investig neuroprotect activ metabolit iii understand structur activ relationship toward neuroprotect microbi transform cyclocephagenol use alternaria eureka result product twenti one previous undescrib metabolit oxid monooxygen dehydr methyl migrat epoxid ring expans reaction observ triterpenoid skeleton structur compound establish nmr hr ms analys neuroprotect activ metabolit parent compound evalu h induc cell injuri structur activ relationship sar establish result reveal sever metabolit potent neuroprotect activ studi reveal select compound reduc amount ros preserv integr mitochondri membran first report microbi transform cyclocephagenol
|
D012502;D027883
|
T002;T109
|
36,323,751
|
real world clinic feasibl direct specimen antimicrobi suscept test clinic specimen unknown microbi load suscept within healthcar set physician use antibiogram offer inform local suscept rate aid select empir antibiot therapi avoid prescript potenti ineffect drug antibiogram display suscept resist data hospit citi region specif level ultim enabl initi antibiogram base empir antibiot treatment ast report individu patient level guid treatment away broad spectrum antibiot toward narrow spectrum antibiot remov antibiot entir despit advantag ast tradit requir h turn around window time critic antimicrobi therapeut intervent herein present direct specimen ast reduc time patient sampl receipt lab ast result biggest challeng perform ast direct unprocess clinic specimen unknown microbi load align categor suscept report clsi refer method start fix inoculum mcfarland unit prepar use coloni sub cultur pilot clinic feasibl studi use de identifi remnant specimen collect mcw observ high low end microbi load demonstr final categor agreement ampicillin ciprofloxacin sulfamethoxazol trimethoprim
|
D000900;D002939
|
T121;T195;T109
|
36,323,749
|
clinic signific prostat volum testosteron reduct lower urinari tract symptom patient prostat cancer undergo androgen depriv therapi investig effect prostat volum serum testosteron chang lower urinari tract symptom patient prostat cancer undergo androgen depriv therapi total patient receiv androgen depriv therapi prostat cancer treatment januari august enrol retrospect studi chang intern prostat symptom score ipss patient group stratifi prostat volum amount testosteron reduct assess everi week week androgen depriv therapi initi longitudin mix model use assess adjust effect prostat volum testosteron reduct ipss chang mean valu ipss total score ipss total void subscor ipss vs storag subscor ipss ss signific decreas baselin week patient small ml larg ml prostat mean valu ipss total ipss vs ipss ss similar decreas patient larg prostat baselin ipss total howev small prostat ipss ss specif remain unchang ipss total ipss vs signific decreas addit patient small prostat ml patient lesser testosteron reduct ngdl show greater improv ipss ss compar greater testosteron reduct ngdl conclus although androgen depriv therapi general improv lower urinari tract symptom may worsen specif storag symptom patient relat small prostat greater testosteron reduct find suggest testosteron may influenc lower urinari tract symptom patient
|
D011471;D059411
|
T184;T191
|
36,323,748
|
antibiot properti satureja montana l hydrol bacteria fungus clinic interest impact non target environment microorgan aim studi analys microbicid microbiostat activ montana hydrol l water solubl fraction hydro distil process use obtain essenti oil gram posit gram negat bacteria fungus clinic interest consid whether hydrol environment friend altern tradit antibiot effect non target microorgan aquat terrestri environ analys use natur soil river microorgan communiti character rrna gene sequenc result show montana hydrol especi effect vv concentr pasteurella aerogen streptococcus agalactia acinetobact baumannii prioriti also microbicid bacteri strain fungus candida albican vv concentr river soil communiti expos hydrol show decreas growth well decreas abil metabol polym carbohydr soil microorgan polym carboxyl keton acid river microorgan hydrol could altern convent antibiot impact environ must taken account
|
D031362;D000890
|
T168;T121;T002
|
36,323,747
|
canalis plastic compon melanin base colour diet manipul experi hous sparrow whether melanin base plumag colour accur reflect bird qualiti still controversi better understand potenti mechan behind observ variat plumag colour shift attent high level express colour low level physiolog phenomena target microstructur pigment content feather well studi model system hous sparrow passer domesticus combin experiment manipul bird physiolog condit avail resourc key product studi colour phenylalanin tyrosin pt found feather sparrow fed control diet notic lower valu bright suggest higher qualiti ornament black comparison sampl bird fed pt reduc diet electron paramagnet reson epr spectroscopi detect higher melanin concentr sampl control pt reduc group multi level analysi exclud mechan barbul densiti melanosom distribut clear point finest level proxi colour concentr melanin melanosom despit melanin manufactur bird endogen effici melanogenesi notic limit diet result bird plumag colour affect may entail consequ social signal
|
D008543;D046370
|
T123;T012;T109
|
36,323,746
|
saliva metabolom alter acut stress major stress system effect bodi advers consequ physic mental health howev molecular basi damag effect remain incomplet understood use longitudin approach characteris acut system impact major psycholog stress pig model perform untarget metabolom non invas obtain saliva sampl pig h transfer novel physic social environ slaughterhous main molecular chang occur includ decreas amino acid b vitamin amino acid deriv metabolit synthes b vitamin depend reaction well yet unidentifi metabolit featur decreas level sever identifi metabolit implic patholog human psycholog disord neurodegen diseas suggest possibl neuroprotect function result provid fingerprint acut effect psycholog stress metabolom suggest candid biomark potenti role stress relat disord
|
D012463;D019636
|
T047;T031
|
36,323,745
|
rhoa vigilin candid immunohistochem marker epithelioid malign mesothelioma diagnost marker malign mesothelioma mm extens investig immunohistochemistri ihc marker calretinin use patholog diagnosi howev diagnost marker requir improv specif sensit patholog diagnosi studi propos two protein diagnost marker epithelioid mm one rhoa mm mutat suscept locus deriv protein anoth vigilin lung small cell carcinoma marker ihc perform use mm epithelioid case sarcomatoid case biphas case lung adenocarcinoma lac lung squamous cell carcinoma lsc normal mesotheli nm tissu major epithelioid mm case posit rhoa vigilin wherea ihc show lower stainabl biphas sarcomatoid mm besid ihc show signific higher stainabl rhoa vigilin epithelioid mm lac lsc p conclus rhoa vigilin may candid immunohistochem marker epithelioid mm
|
D000086002;D008654;D000077192;D008175;D002289;D002294
|
T191
|
36,323,743
|
season variat airborn microbi assemblag seoul subway south korea gene profil chemic analysi studi determin season airborn microbi divers profil smrt station sequenc rrna particul matter sampl collect air purifi instal platform area smrt subway station three station includ crowd one select sampl sampl done season extract total dna season sampl pcr perform illumina overhang adapt primer v v region rrna gene region gene amplifi product purifi sequenc librari made sequenc carri illumina miseq sequenc system illumina usa follow depth divers analys element composit particul matter sampl collect differ subway station obtain use wd xrf spectromet smrt microbiom show extens taxonom divers common bacteri genera subway station associ skin overal station includ studi harbor differ phylogenet communiti base divers comparison microbi assemblag also vari depend upon season sampl taken station major element present subway station aerosol generat wheel brake cushion catenari pantograph studi show microbi composit smrt subway station come divers combin environment human sourc season lifestyl commut
|
D011890
|
T073
|
36,323,742
|
effect high fat diet induc obes pathophysiolog immun cell therapeut efficaci system lupus erythematosus prior studi suggest strong link obes autoimmun diseas studi aim evalu effect high fat diet hfd induc obes diseas pathogenesi immun cell infiltr therapeut efficaci system lupus erythematosus sle treatment methylprednisolon signific increas surviv control diet group hfd group hfd signific increas incid sever proteinuria glucos intoler regardless diet treatment methylprednisolon signific decreas serum level anti dsdna antibodi il il interferon induc protein ip improv renal patholog score treatment methylprednisolon signific lower serum level il mcp tnf control diet group hfd group hfd signific increas proport cd cell signific decreas proport cell white adipos tissu methylprednisolon treatment signific rescu effect hfd group methylprednisolon treatment signific decreas increas foxp rort cell spleen compar untreat group data improv understand effect hfd therapeut efficaci corticosteroid sle treatment could clinic implic
|
D059305;D008180
|
T061;T047
|
36,323,741
|
select speci specif panel refer gene peripher blood mononuclear cell nativ livestock speci adapt tran himalayan region leh ladakh identif appropri refer gene integr compon gene express base studi get accuraci reliabl data interpret studi evalu express stabil candid refer gene gapdh rpl eefa rps hprt uxt rps bm rps actb peripher blood mononuclear cell livestock speci adapt high altitud hypoxia condit leh ladakh total pbmcs sampl six nativ livestock speci leh ladakh region ladakhi cattl ladakhi yak ladakhi donkey chanthangi goat doubl hump cattl zanskar poni includ studi common use statist algorithm genorm normfind bestkeep reffind employ assess stabil rgs livestock speci studi identifi differ panel refer gene speci exampl eefa rpl ladakhi cattl gapdh rps actb ladakhi yak hprt bm actb ladakhi donkey hprt bm actb doubl hump camel rps hprt changthangi goat hprt actb zanskar poni best knowledg first systemat attempt identifi panel rgs across differ livestock speci type adapt high altitud hypoxia condit futur find present studi would quit help conduct transcript studi understand molecular basi high altitud adapt nativ livestock popul leh ladakh
|
D007963;D000532
|
T047;T025
|
36,323,740
|
direct akt activ tumor infiltr lymphocyt mark increas interferon ifn regress tumor resist pd checkpoint blockad pd immun checkpoint blockad inhibitori receptor receptor program cell death pd revolution cancer treatment effect immun reactiv tumour antigen requir infiltr activ tumour infiltr cell til context ligat antigen receptor complex tcr combin co receptor cd activ intracellular mediat akt pkb protein kinas b downstream target pd inhibit activ aktpkb given assess whether direct activ akt might effect activ immun system limit growth tumor resist pd checkpoint blockad found small molecul activ akt sc limit growth b tumor emt syngen breast tumor model poor respons pd immunotherapi case b tumor direct akt activ induc reduct suppressor regulatori treg til ii increas effector cd til sc vivo therapi caus major increas number cd cd til express interferon ifn effect ifn express distinguish respons non respons anti tumor respons could recapitul ex vivo human cell cdfoxptreg til akt induc ifn express accompani loss suppressor activ convers cd helper th like til mark reduct phospho shp cd til observ increas phospho activ plc genet delet transcript factor bet tbx block increas ifn express subset ablat therapeut benefit sc tumor growth studi show akt activ therapi act induc ifn cd cd til accompani intra tumor convers suppress treg cd th like cell augment cd respons
|
D016246;D009369
|
T191;T025
|
36,323,739
|
design amino acid carbohydr base anticanc drug inhibit polymeras dna polymeras pol signific valu design new famili anticanc drug protein take role mani stage cell cycl includ dna replic transles dna synthesi repair process dna accord mani studi high level express pol case associ low rate patient surviv regardless consid stage tumor cell thus design new drug fewer side effect inhibit pol cancer cell attract attent recent year project aim design explor altern inhibitor pol base carbohydr amino acid term physicochem properti similar tradit anticanc drug cytarabin cytosin arabinos altern inhibitor suppos disrupt dna replic process cancer cell prevent tumor cell mitosi newli design structur base natur product expect non toxic chemotherapeut impact tradit agent combinatori use quantum mechan studi molecular dynam simul enabl us precis predict inhibit mechan newli design structur base carbohydr amino acid compar tradit chemotherapeut drug cytarabin result suggest inhibitor contain natur build block amino acid carbohydr could consid altern drug cytarabin block pol
|
D000596;D000970
|
T123;T121;T116;T109
|
36,323,738
|
differenti express immun regulatori protein car cleca nlrp peripher blood mononuclear cell earli stage non small cell lung cancer patient chang gene express profil peripher blood mononuclear cell pbmc appear repres host respons cancer cell via paracrin signal specul protein express circul lymphocyt repres lymphocyt traffick infiltr tumor microenviron possibl use protein express circul lymphocyt biomark discrimin earli stage non small cell lung cancer nsclc explor four independ pbmc gene express microarray dataset gse gse gse gse analyz select car cleca nlrp base signific protein express tumor infiltr lymphocyt normal lymphoid tissu valid studi use autom flow cytometri conduct studi particip includ treatment naiv earli stage non small cell lung cancer patient nsclc individu non malign pulmonari diseas healthi individu median ratio car cleca nlrp specif antibodi stain cd posit cell earli stage nsclc patient compar healthi control vs p vs p vs p respect median fluoresc intens mfi cd car cd cleca cd nlrp express earli stage nsclc patient compar healthi volunt vs p vs p vs p respect nlrp cd ratio cd car cd cleca cd nlrp mfi signific higher earli stage nsclc healthi volunt area roc curv cd nlrp mfi provid distinguish express sensit specif furthermor cd nlrp mfi potenti discrimin earli stage nsclc malign mimic inflamm infect pulmonari diseas valid various pulmonari inflammatori diseas might warrant proof principl find strengthen hypothesi malign generat distinct protein express fingerprint circul lymphocyt
|
D002289;D008175;D055752
|
T191
|
36,323,737
|
ecolog transit sustain develop integr statist indic support public polici evolut concept sustain avail new statist inform requir constant check set indic accur perform task repres well societi sustain develop goal refer various develop domain relat environment social econom institut issu place basi mission envisag nation recoveri resili plan nrrp specif subject ecolog transit relat statist indic evalu effect program implement nrrp pursu practic signific interest numer data avail analyz region level multivari statist methodolog total fuzzi relat method capabl synthes various inform evalu territori adequaci econom plan various compon represent gis basi geograph distribut synthesi valu fuzzi indic paper highlight differ start point exist italian region integr statist indic help public polici orient coher way environment declar object start avail multipl data develop integr approach evalu local govern polici place monitor progress subsequ intervent italian govern
|
D000076502;D011640
|
T078;T068;T064;T067
|
36,323,735
|
detect mitochondri dna mutat circul mitochondria origin extracellular vesicl potenti diagnost applic pancreat adenocarcinoma complet lack high sensit specif biomark earli pancreat ductal adenocarcinoma pdac diagnosi limit multi modal therapeut option mitochondri dna mtdna excel resourc biomark discoveri high copi number increas mutat frequenc cancer cell examin mtdna mutat detect circul extracellular vesicl ev pdac patient use discern cancer non cancer subject greater yield circul ev fold p obtain pdac patient n non cancer nc individu n pdac ev contain higher quantiti total dna fold p nc ev greater enrich mtdna fold p pdac ev also higher level cardiolipin mitochondri inner membran phospholipid suggest mitochondri origin mtdna mutat pdac ev uniqu frequenc remark higher mtdna mutat pdac ev respiratori complex rci nd nd follow rciii gene cytb among non code gene loop rnr exhibit mutat altogeth studi establish first time mtdna mutat detect circul ev potenti serv tool reliabl pdac diagnosi
|
D010190;D000230;D021441;D000067128
|
T026;T191
|
36,323,734
|
detect rare prostat cancer cell human urin offer prospect non invas diagnosi two molecular cytolog approach time gate immunoluminesc assay tgia ii raman activ immunolabel assay ria develop detect prostat cancer pca cell urin five prostat cancer patient tgia pca cell stain biocompat europium chelat antibodi conjug probe quantit autom time gate microscopi osam ria pca cell label antibodi conjug raman probe detect raman spectromet tgia ria first optim detect pca cultur cell du spike control urin tgia osam show singl cell pca detect sensit ria limit detect cellsml blind analysi patient urin sampl use mil antibodi specif pca cell perform use assay parallel control urin assay detect low abund pca cell patient urin pca cell per ml tgia cellsml ria normal mean detect pca cell per ml urin plot clinic data includ prostat specif antigen psa level clinic risk assess patient cell detect assay show correl psa high risk patient align clinic assess rather psa level lowintermedi risk patient despit limit avail urin sampl pca patient data present proof principl work promis develop high sensit diagnost urin test pca
|
D017430;D011471
|
T129;T191;T126;T116
|
36,323,733
|
experi covid pandem wuhan lead last increas social distanc th jan first covid relat death confirm wuhan hubei chines govern respond outbreak lockdown impact resid hubei provinc last almost three month time lockdown strictest within china worldwid use interact web base experi conduct half year lockdown particip chines provinc investig behavior effect shock event experienc popul hubei find one place resid strict lockdown measur provinc robust predictor individu social distanc behavior observ inform messag effect increas complianc social distanc throughout china wherea fine noncompli work better within hubei provinc relat rest countri also report resid hubei increas propens social distanc expos social environ character presenc superspread effect present outsid provinc result appear specif context covid explain general differ risk attitud social prefer
|
D000086382
|
T047;T067
|
36,323,732
|
discoveri structur character chicor acid sar cov nucleocapsid protein ligand rna bind disruptor nucleocapsid n protein play critic role coronavirus genom transcript packag repres key target develop novel antivir structur inform ligand bind scarc use novel fluoresc polar assay identifi small molecul disrupt bind n protein target rna deriv sar cov genom packag signal sever phenol compound includ l chicor acid ca identifi high affin n protein ligand bind ca n protein confirm isotherm titrat calorimetri h std n hsqc nmr crystal structur ca bound n protein c termin domain ctd reveal new modulatori site sar cov n protein moreov ca reduc sar cov replic cell cultur data thus open venu develop new antivir target n protein essenti yet underexplor coronavirus target
|
D000086402;D000086382
|
T005;T067;T047
|
36,323,731
|
novel venetin nanoparticl earthworm coelom fluid promis agent treatment non small cell lung cancer present research show antitumor activ protein polysaccharid complex venetin obtain coelom fluid dendrobaena veneta earthworm cancer cell investig continu experi antitumor activ coelom fluid obtain speci venetin nanoparticl obtain thermal treatment coelom fluid separ coelomocyt filtrat lyophil prepar show select effect cancer cell wherea normal cell unaffect venetin effect lung cancer cell dose gml result imag use light microscopi scan electron microscopi sem cell die main via apoptosi pathway necrot cell appear sporad microscop view sem imag reveal complet destruct cell incub venetin atom forc microscopi afm analys show chang topographi peak forc error imag young modulus elast cell incub venetin transmiss electron cryomicroscopi cryo tem analysi indic polymer natur analyz prepar sampl venetin show homogen size profil microparticl size approxim nm signific decreas venetin bind sphingomyelin observ venetin lost pore form activ deactiv pore form activ occur confirm absenc hemolyt capac venetin toward red blood cell conduct analys show suitabl obtain complex biomed research next step consist analys effect venetin immun system mice
|
D009835;D002289;D008175;D053758
|
T191;T073;T204
|
36,323,730
|
associ thyroid cancer cardiovascular diseas risk nationwid observ studi treatment levothyroxin radioiodin contribut altern cardiovascular function adult thyroid cancer risk long term cardiovascular condit among thyroid cancer patient unknown studi aim compar incid coronari heart diseas chd ischem stroke atrial fibril af among adult thyroid cancer general popul especi stratifi age year old observ cohort studi enrol patient januari decemb follow decemb studi analyz data taiwanes thyroid cancer patient regist nation taiwan cancer registri databas chd sir model use evalu associ thyroid cancer chd af cardiovascular diseas outcom stratifi age sex sir analys also conduct sex age group year differ follow year exclud individu year year old miss index data elig thyroid cancer patient without chd histori patient without histori patient without af histori includ analysi median follow year among thyroid cancer patient observ number new chd event af respect sir signific higher chd sir confid interv ci among thyroid cancer patient compar age sex specif standard popul howev associ thyroid cancer risk sir ci cardiovascular diseas sir ci atrial fibril sir ci insignific moreov stratif age age year old sex chd suggest diagnosi thyroid cancer young may attenu chd risk sir ci cvd risk constant among men sir ci women sir ci patient persist higher chd risk year cancer diagnosi thyroid cancer survivor substanti chd risk even long term follow especi patient year old research associ thyroid cancer chd risk warrant
|
D001281;D002318;D013964;D003327;D000083242
|
T047;T046;T191
|
36,323,729
|
laboratori base experiment research effect diagenesi heat bone implic improv tool characteris ancient fire use fire consid one import cultur innov human evolut understand taphonomi fire remain import prerequisit valid interpret hominin fire relat behaviour present result seri laboratori base experi test effect differ ph condit acid neutral alkalin physic chemic properti heat bone char combust take fundament research approach studi give insight specif effect ph exposur under chemic process provid data appli heat bone context time period result show diagenesi signific impact preserv potenti heat bone well reliabl analyt techniqu use reconstruct past heat condit studi provid refer data toolkit analysi heat bone explicit take diagenesi account offer signific improv accuraci reconstruct heat condit fire relat human behaviour past
|
D005390;D015186
|
T015;T067
|
36,323,728
|
explor novel effici sourc product bacteri nanocellulos bioprocess optim character demand bacteri nanocellulos expect rise come year due wide usabl mani applic henc continu need screen soil sampl various sourc isol strain high capac bacteri nanocellulos product bacillus sp strain see isol soil sampl collect barhiem menoufia governor egypt display high bnc product submerg ferment bacillus sp strain see identifi bacillus tequilensi strain see static cultur bnc obtain layer grown air liquid interfac ferment medium respons surfac methodolog use optimis process paramet highest bnc product gl obtain use gl pepton gl yeast extract vv cantaloup juic gl na hpo gl citric acid ph medium volum ml ml conic flask inoculum size vv temperatur c incub time day bnc purifi character scan electron microscopi sem energi dispers x ray edx spectroscopi differenti scan calorimetri dsc x ray diffract xrd fourier transform infrar spectroscopi ftir thermogravimetr analysi tga transmiss electron microscopi tem
|
D001419;D012987
|
T007;T167
|
36,323,727
|
portabl low cost hologram verif modul use snapshot base hyperspectr imag algorithm one challeng differenti duplic hologram origin one reflect slight chang light condit complet chang reflect pattern exhibit hologram consequ standard duplic hologram detector yet creat studi portabl low cost snapshot hyperspectr imag hsi algorithm base hous modul differenti origin duplic hologram propos modul consist raspberri pi processor raspberri pi camera display light emit diod light system dimmer visibl hsi algorithm could convert rgb imag captur raspberri pi camera hyperspectr imag establish specif region interest select spectral imag mean gray valu mgv reflect measur result suggest shorter wavelength suitabl differenti hologram use mgv paramet classif longer wavelength suitabl use reflect key featur design includ low cost simplic lack move part requir addit decod key
|
D000081862;D000465
|
T170;T059
|
36,323,726
|
pathogenom comparison global phylogeni escherichia coli st strain escherichia coli st strain belong clinic import phylogroup f dissemin worldwid human anim environ elucid pathogenom global collect e coli st isol divers sourc retriev public databas high qualiti sequenc complet genom colistin resist e coli strain cfsan isol raw milk chees design refer strain cfsan belong h st pathotyp carri conjug colv plasmid pcfsan combin extraintestin virul gene ompt sita iron etsc trat cvac hylf iss tsh mchf iucc iuta multidrug resist island bla tem aph id aph ib sul dfra compar genom analysi reveal high frequenc pcfsan like plasmid e coli st notabl evolutionari genet event e coli st strain acquisit pcfsan like plasmid confer resist sever antimicrobi tellurium quaternari ammonium compound ident virul antibiot resist profil identifi human anim strain worrisom first studi emphas signific e coli st global high risk virul multidrug resist clone zoonot potenti
|
D004927;D029968
|
T047;T116
|
36,323,725
|
energi leakag current monitor system abnorm detect electr applianc unsaf electr applianc hazard human caus electr fire monitor analyz control purpos studi monitor system condit includ electr properti applianc diagnos fault condit without deploy sensor individu applianc analyz individu sensor data use histor data accept rang normal leakag current propos hybrid model base multiclass support vector machin msvm integr rule base classifi rbc determin chang leakag current caus instal devic certain moment develop sensor base monitor devic long rang communic store real time data cloud databas model process rbc algorithm use diagnos construct devic fault overcurr fault msvm appli detect leakag current fault conduct oper field test develop devic integr hous result demonstr effect propos system term electr safeti monitor detect collect data store structur databas could remot access internet
|
D004560;D000465
|
T070;T170
|
36,323,724
|
fish feed supplement calcium base buffer miner decreas stomach acid increas blood alkalin tide cost digest predatori fish wild consum whole prey includ hard skelet part like shell bone shell bone made buffer miner calcium carbon caco calcium phosphat ca po miner resist chang ph mean could physiolog consequ gastric acid digest metabol fish use isocalor diet supplement either caco ca po cacl non buffer control investig impact dietari buffer energet cost digest ie specif dynam action sda gastric ph postprandi blood alkalosi alkalin tide growth juvenil rainbow trout oncorhynchus mykiss increas dietari buffer signific associ increas stomach chyme ph postprandi blood hco net base excret total sda peak sda influenc growth effici day trial result show aspect meal nutrit valu influenc physiolog energet cost associ digest fish reduct sda alway lead improv growth effici discuss broader implic find gastrointestin physiolog fish trade off prey choic wild anthropogen warm feed formul aquacultur
|
D002118;D017686
|
T123;T196;T121;T013
|
36,323,721
|
pairwis high order depend cryptocurr trade network paper analys effect inform flow cryptocurr market first defin cryptocurr trade network ie network made use cryptocurr node granger causal among week log return link later analys evolut time particular refer year studi logarithm us dollar price return cryptocurr trade network use pairwis high order statist depend quantifi granger causal inform respect refer former find show peak correspond import event like eg covid pandem turbul occasion sudden price rise correspond network structur rather stabl across week time window period consid coin influenti node network pairwis descript network stabl coin seem play margin role wherea turn high order depend appear highest number synergist inform circuit thus prove play major role high order effect refer redund synergi time evolut total transact us dollar find larg volum first semest seem trigger transit cryptocurr network toward complex dynam landscap result show pairwis high order descript complex financi system provid complementari inform cryptocurr analysi
|
D058873;D000086382
|
T047;T067
|
36,323,720
|
n methyladenosin rna modif promot viral genom rna stabil infect molecular manipul suscept gene antipod resist r gene adopt altern strategi control crop diseas show gene encod triticum aestivum methyltransferas b tamtb identifi genom wide associ studi subsequ shown posit regul wheat yellow mosaic virus wymv infect tamtb local nucleus transloc cytoplasm aggreg bind wymv nib upregul level wymv rna stabil viral rna thus promot viral infect natur mutant allel tamtb snpc found confer enhanc suscept wymv infect genet variat analysi wheat varieti discoveri highlight allel use target molecular wheat breed futur
|
D014908;D019176
|
T168;T005;T002
|
36,323,718
|
mobil eeg studi psychophysiolog effect walk crowd indoor outdoor urban environ environment psychologist establish multipl psycholog benefit interact natur compar urban environ emot cognit attent yet given increas urbanis worldwid equal import understand differ within differ urban environ influenc human psycholog experi develop laboratori experi examin psychophysiolog effect physic outdoor indoor social crowd versus uncrowd environ healthi young adult valid use mobil electroencephalographi eeg electroderm activ eda measur activ walk particip n random assign walk stand group watch six min walk video green urban indoor urban outdoor environ depict high low level social densiti self report emot state show green space perceiv calm posit reduc attent demand outdoor urban space perceiv posit indoor environ find consist earlier studi psycholog benefit natur confirm effect paradigm stimuli addit hypothesis even short term exposur crowd scene would negat psycholog effect found crowd scene evok higher self report arous negat self report valenc recruit cognit attent resourc howev walk particip evok higher frontal alpha asymmetri suggest posit affect respons furthermor found use recent signal process method eeg data produc compar signal nois ratio walk stand despit differ walk stand skin conduct also captur effect psychophysiolog respons stimuli result suggest emot respons visual present stimuli measur effect use mobil eeg eda ambulatori set complex interact activ walk social densiti urban space direct indirect affect respons environ
|
D016138;D004569
|
T060;T056;T034;T169
|
36,323,717
|
improv filtrat properti manganes tetroxid mud util perlit particl drill wide rang permeabl sandston format requir featur drill formul mitig format damag excel filtrat filter cake properti key factor prevent limit format damag improv seal qualiti plan drill fluid studi new novel filtrat agent call perlit introduc improv manganes tetroxid mud cake abil better seal featur perlit particl load formul contain manganes tetroxid weight agent water base drill mud design high densiti ppg perlit ad vari concentr reach optimum perform filtrat test conduct reservoir temperatur f differenti pressur psi form filter cake test perform use sandston core two differ permeabl categori low high permeabl filtrat media gave full pictur perlit perform implement differ format properti consid drill fluid properti form filter cake structur chemic composit evalu use scan electron energi dispers x ray sem ed present result illustr perlit compat ad manganes tetroxid weight agent formul addit capac improv filter cake seal qualiti lower filtrat volum filter cake intern extern layer permeabl respect moreov ed analysi show perlit particl concentr general intern layer filter cake
|
D008345;D005374
|
T068;T123;T196
|
36,323,716
|
effect local anesthesia pain scale specimen adequaci fine needl aspir biopsi thyroid nodul liquid base cytolog fine needl aspir biopsi fnab routin diagnost test thyroid nodul use local anesthesia la procedur still controversi prospect studi aim evalu degre pain specimen adequaci liquid base cytolog lbc fnab thyroid nodul without la total consecut patient thyroid nodul underw fnab without la januari decemb includ patient receiv la signific lower immedi pain scale score p multivari analysi demonstr use la odd ratio confid interv ci p lesion abut trachea ci p independ signific associ pain degre immedi fnab higher proport patient previous underw fnab thought la help perform prior fnab howev use la improv specimen adequaci p result show administr la proper techniqu ultrasound guid fnab might reduc immedi pain procedur patient may experi pain aspir nodul abut trachea
|
D016606;D013964
|
T191
|
36,323,715
|
bioinformat analysi prognost valu immunolog role mecp pan cancer methyl cpg bind protein mecp import epigenet regulatori factor promot mani tumor develop liver cancer breast cancer colorect cancer far pan cancer analysi report therefor studi aim explor pan cancer prognost valu immun infiltr pattern biolog function use bioinformat method analyz express prognost signific mecp relationship mecp clinicopatholog paramet genet variat methyl phosphoryl immun cell infiltr biolog function pan cancer use public databas result show express mecp regul cancer regul cancer remark correl prognosi patholog stage grade subtyp cancer promot methyl level mecp dna decreas bladder urotheli carcinoma blca breast invas carcinoma brca liver hepatocellular carcinoma lihc prostat adenocarcinoma prad uterin corpus endometri carcinoma ucec testicular germ cell tumor tgct stomach adenocarcinoma stad decreas phosphoryl found mecp ucec lung adenocarcinoma luad ovarian serous cystadenocarcinoma ov colon adenocarcinoma coad kidney renal clear cell carcinoma kirc furthermor mecp express signific associ multipl immunomodul immun cell infiltr level across tumor therefor pan cancer explor prognost marker immunotherapeut valu mecp differ cancer
|
D000230;D002295;D003110;D001749;D002292;D001943;D007680
|
T191
|
36,323,713
|
stromal androgen signal act tumor nich drive prostat basal epitheli progenitor initi oncogenesi androgen receptor ar signal pathway essenti prostat tumorigenesi although signific effort devot direct target ar express tumor cell therapi fail prostat cancer patient demonstr loss ar stromal sonic hedgehog gli lineag cell diminish prostat epitheli oncogenesi tumor develop use vivo assay mous model singl cell rna sequenc analys identifi robust increas insulin like growth factor igf bind protein express ar defici stroma attenu ar suppress sp regul transcript inhibit igf induc wnt catenin activ adjac basal epitheli cell repress oncogen growth tumor develop epitheli organoid stromal ar defici mice regain igf induc oncogen growth loss human prostat tumor basal cell signatur reveal basal cell stromal ar defici mice data demonstr distinct mechan prostat tumorigenesi implic co target stromal epitheli ar signal prostat cancer
|
D011467;D011471
|
T023;T191
|
36,323,712
|
deep learn model predict epstein barr virus associ gastric cancer histolog detect epstein barr virus ebv gastric cancer patient crucial clinic decis make relat specif treatment respons prognos despit import limit medic resourc preclud univers ebv test herein propos deep learn base ebv predict method h e stain whole slide imag wsi model develop use h e stain wsi ebv posit tcga dataset cancer genom atlas wsi ebv posit ish dataset independ institut deep learn model ebvnet consist two sequenti compon tumor classifi ebv classifi visual learn represent classifi use umap extern valid model use addit wsi ebv posit hgh dataset compar model perform four pathologist ebvnet achiev auprc wherea four pathologist yield mean auprc moreov ebvnet achiev negat predict valu sensit specif precis f score respect propos model expect contribut prescreen patient confirmatori test potenti save test relat cost labor
|
D013274;D020031;D000077321
|
T047;T191;T066
|
36,323,711
|
innov approach evalu prolong disord conscious use nf l gfap biomark pivot studi behavior assess clinic evalu prolong disord conscious patient could suffici correct diagnosi prognost aim use innov approach involv ultra sensit determin biolog marker correl imag paramet investig prolong disord conscious pdoc assess serum concentr neurofila light chain nf l glial fibrillari acid protein gfap pdoc n healthi control hc n well sever clinic imag paramet fraction anisotropi fa whole brain suv white matter hyperintens volum wmh use pet mri acquisit differenti diagnosi task imag wmh volum abl discrimin veget stateunrespons wake syndrom vsuw minim conscious state mcs patient p valu select marker imag vitro abl differenti pdoc patient hc subject level serum nf l concentr signific differ accord clinic progress conscious recoveri p valu highlight potenti play longitudin manag patient
|
D003243;D007382
|
T026;T041
|
36,323,710
|
optim bias relat scenario valenc gender social insecur attach optim bias refer tendenc display unjustifi highlow expect futur positiveneg event studi ask particip estim likelihood differ event investig optim bias oneself general popul bias influenc gender valenc event social event well attach anxieti attach avoid found social interact gender differ optim bias social vs alon event larger among women among men attach anxieti main reduc optim bias among men deliber futur alon situat attach avoid primarili reduc optim bias among femal respond deliber futur social interact result may implic well motiv differ attach men women ultim inspir psychotherapi intervent
|
D000067656;D009042
|
T078;T055;T041;T080
|
36,323,708
|
synthesi new hydrophob coat film stearic acid buffalo fat experi involv chemic convers pure stearic acid buffalo adipos tissu waxi stearyl stearat subsequ appli coat film extend shelf life recent harvest fruit fat extract minc adipos tissu use dri render procedur character extract fat hydrolyz mixtur free fatti acid glycerol supercrit co extractor use stearic acid individu extract pure form free fatti acid mixtur confirm accord melt point c element analysi gc ms esterifi fatti acid isol stearic acid use synthesi new hydrophob wax name stearyl stearat chemic structur prepar compound establish accord element analysi spectral data new hydrophob wax use coat film enhanc shelf life fresh harvest tomato fruit therefor stearyl stearat solut wv diethyl ether use tomato coat compar chitosan coat tomato weight loss ph fruit firm ascorb acid concentr total solubl solid studi period day c relat humid result reveal coat stearyl stearat solut wv diethyl ether could delay tomato ripen experi condit sensori evalu coat tomato carri show accept tast tomato coat stearyl stearat hand acut oral toxic stearyl stearat use albino mice show complet safeti gkg mice weight
|
D002020;D018551
|
T168;T015;T002
|
36,323,707
|
optic gearbox enabl versatil multiscal high throughput multiphoton function imag understand function mechan biolog system crucial observ cellular dynam high spatiotempor resolut within live anim recent advanc genet encod function indic signific improv respons rate near millisecond time scale howev wide employ vivo imag system often lack tempor solut captur fast biolog dynam broad enabl capabl high speed vivo deep tissu imag develop optic gearbox add modul optic gearbox convert common multiphoton imag system versatil multiscal high throughput imag applic work demonstr vivo function imag mammalian brain frame rate rang hz optic gearbox versatil compat wide employ imag compon high valuabl varieti deep tissu imag applic
|
D003952;D001921
|
T060;T023
|
36,323,706
|
secur secondari util system genom data use quantum secur cloud secur storag secondari use individu human genom data increas import genom research person medicin current necessari store whole genom sequenc inform fastq data enabl detect de novo mutat structur variat analysi hereditari diseas cancer furthermor bioinformat tool analyz fastq data frequent updat improv precis recal detect variant howev exist secur secondari use data multi parti comput homomorph encrypt handl limit algorithm usual requir huge comput resourc develop high perform one stop system larg scale genom data analysi secur secondari use data data owner multipl user differ level data access control quantum secur cloud system distribut secur genom data analysi system dsgd trust server built quantum secur cloud inform theoret secur tokyo qkd network trust server capabl deploy run varieti sequenc analysi hardwar gpus fpgas well cpu base softwar demonstr dsgd achiev compar throughput without encrypt trust server therefor system readi instal research institut hospit make diagnos base whole genom sequenc daili basi
|
D000067917;D016494
|
T078;T080;T066;T170;T097;T057
|
36,323,705
|
fuse raman spectroscop analysi blood saliva deliv high accuraci head neck cancer diagnost rapid label free non destruct analyt measur requir littl sampl prepar raman spectroscopi show great promis liquid biopsi cancer detect diagnosi carri raman analysi mass spectrometri plasma saliva subject cohort head neck cancer patient benign control eg patient benign oral mass unsupervis data model built assess diagnost perform raman spectra collect either biofluid provid moder perform discrimin cancer sampl howev fuse togeth raman spectra plasma saliva patient subsequ analyt model deliv impress sensit specif accuraci respect confirm metabolit drive differ raman spectra model among one drive mass spectrometri model unifi two techniqu valid under abil raman assess metabolit composit studi bolster relev raman provid addit valu probe uniqu chemic composit across biofluid sourc ultim show simpl data augment routin fuse plasma saliva spectra provid signific higher clinic valu either biofluid alon push forward potenti clinic translat raman spectroscopi liquid biopsi cancer diagnost
|
D013059;D006258
|
T070;T059;T191
|
36,323,704
|
penalti feet posit rule modif later effect soccer goalkeep dive kinemat new rule appli soccer allow goalkeep one foot part goal line kicker hit ball unlik previous rule determin goalkeep feet line purpos present studi analyz chang rule lower limb later influenc dive save kinemat perform penalti six goalkeep two profession four amateur perform total dive laboratori forc impuls exert lower limb displacementveloc data center bodi mass collect forc plate kinemat analysi side prefer collect inventori result show goalkeep dive p faster p dive accord new rule dive non domin side present higher valu trial domin side mediolater p result p displac conclud goalkeep perform better new rule analyz variabl lower limb prefer influenc mediolater result displac
|
D012916;D004242
|
T056
|
36,323,703
|
share genet risk factor causal associ psoriasi coronari arteri diseas psoriasi coronari arteri diseas cad relat comorbid well establish whether genet basi under well studi appli tran diseas meta analysi psoriasi cad case along associ control identifi one oppos three share genet loci confirm coloc analysi combin result bayesian credibl interv analysi independ inform genom epigenom spatial chromatin organ priorit gene includ ifih ila implic common molecular mechan involv psoriasi cad inflammatori signal chronic system inflamm associ cad myocardi infarct mendelian random analysi find cad exposur signific causal effect psoriasi p follow adjust bmi waist hip ratio togeth find suggest system inflamm caus cad increas risk psoriasi
|
D003324;D011565
|
T047
|
36,323,699
|
phosphoryl hydroxysteroid dehydrogenas serin attenu nonalcohol fatti liver diseas mice hydroxysteroid dehydrogenas hepatocyt specif lipid droplet associ protein common loss function variant hsdb rs ta protect patient non alcohol fatti liver diseas under mechan incomplet understood present studi identifi serin hsd evolut conserv pka target site phosphoryl facilit lipolysi promot interact atgl lipid droplet target mutat ser ala sa decreas atgl depend lipolysi cultur hepatocyt reduc cgi mediat atgl activ import transgen knock mous strain carri hsdb sa mutat hsdb aa spontan develop hepat steatosi reduc lipolysi increas inflamm moreov hsdb aa mice suscept high fat diet induc nonalcohol steatohepat final find reproterol potenti hsd modul fda approv drug confer protect nonalcohol steatohepat via pka mediat ser phosphoryl hsd therefor target ser phosphoryl site could repres potenti approach treat nash
|
D065626
|
T047
|
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