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biomedical-topic-categorization-validation

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35.7M
36.4M
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36,323,698
character collagen respons bone fractur heal use polar shg studi extend three paramet analysi approach util noninvas dual liquid crystal base polar resolv second harmon generat shg microscopi facilit quantit character collagen type ii fractur heal tissu shg imag various linear circular polar state analyz quantifi term peptid pitch angl pa shg circular dichroism cd anisotropi paramet ap result show collagen pa valu week fractur heal collagen type ii domin week collagen type domin moreov shg cd ap valu differ collagen type differ chang tendenc extract pa shg cd ap paramet heal time consist collagen properti healthi nonfractur bone thus feasibl propos dual liquid crystal base polar shg method differenti collagen type ii bone fractur heal tissu confirm
D017102;D003094
T123;T121;T116;T042;T122
36,323,697
lncrnas biomark predict radioresist surviv cancer meta analysi effect long noncod rnas lncrnas radiotherapi respons gradual reveal systemat review meta analysi aim evalu associ function under mechan lncrnas regul radiosensit radioresist differ tumor hazard ratio hrs correspond confid interv cis calcul estim effect lncrnas cancer patient prognosi includ overal surviv os recurr free surviv rfs diseas free surviv dfs progress free surviv pfs collect lncrnas cancer type enrol lncrnas downregul relat radiosensit lncrnas upregul relat radioresist lncrnas upregul relat radiosensit cancer furthermor microrna pathway target differ lncrnas contribut cancer radiotherapi respons meta analysi individu pool hrs cis downregul radiat resist upregul radiat resist lncrnas os respect result show lncrnas could modul tumor radioresist sensit affect radiat relat signal pathway serv potenti biomark predict radiotherapi respons
D062085;D009369;D035683
T123;T191;T114
36,323,696
self mix microtubul kinesin activ fluid nonuniform uniform distribut activ activ fluid applic micromix littl known mix kinemat system spatiotempor vari activ investig uv activ cage atp use activ control region microtubul kinesin activ fluid mix process observ fluoresc tracer molecular dye low pclet number diffus transport activ inact interfac progress toward inact area diffus like manner describ simpl model combin diffus micha menten kinet high pclet number convect transport activ inact interfac progress superdiffus like manner qualit captur activ fluid hydrodynam model coupl atp transport result show activ fluid mix involv complex coupl distribut activ stress activ transport atp reduc mix time suspend compon decreas impact initi compon distribut work inform applic activ fluid promot micromix microfluid devic
D016547;D008870
T026;T123;T126;T116
36,323,693
reactiv astrocyt transduc inflamm blood brain barrier model tnf stat signal axi secret alpha antichymotrypsin astrocyt critic compon neurovascular unit support blood brain barrier bbb function patholog transform astrocyt reactiv state protect harm bbb function use human induc pluripot stem cell ipsc deriv bbb co cultur model show tumor necrosi factor tnf transit astrocyt inflammatori reactiv state caus bbb dysfunct activ stat increas express serpina encod alpha antichymotrypsin act contextu find correl astrocyt stat activ vascular inflamm postmortem human tissu murin brain organotyp cultur astrocyt specif silenc serpinan reduc vascular inflamm tnf challeng last treatment recombin serpinan ex vivo explant cultur vivo suffici induc bbb dysfunct relat molecular chang overal result defin tnf stat act signal axi driver inflammatori reactiv astrocyt signatur contribut bbb dysfunct
D001812;D057026
T023;T025
36,323,689
cholinerg basal forebrain degener due sleep disord breath exacerb patholog mous model alzheim diseas although epidemiolog studi indic sleep disord breath sdb obstruct sleep apnea strong risk factor develop alzheim diseas ad mechan risk remain unclear develop method model sdb mice replic key featur human condit alter breath sleep sleep disrupt moder hypoxemia cognit impair induc sdb famili ad model mice display exacerb cognit impair patholog featur ad includ increas level amyloid beta inflammatori marker well select degener cholinerg basal forebrain neuron patholog featur induc chronic hypoxia sleep disrupt alon result also reveal cholinerg neurodegener mediat accumul nuclear hypoxia induc factor alpha furthermor restor blood oxygen level sleep prevent hypoxia prevent patholog chang induc sdb find suggest signal mechan wherebi sdb induc cholinerg basal forebrain degener
D000544;D066187;D012891
T047;T023;T048
36,323,688
comprehens bioconductor ecosystem design crispr guid rnas across nucleas technolog success crispr mediat gene perturb studi high depend qualiti grnas sever tool develop enabl optim grna design howev tool adapt latest crispr modal nucleas offer comprehens annot method advanc crispr applic present new ecosystem r packag call crisprvers enabl effici grna design annot multitud crispr technolog includ crispr knockout crisprko crispr activ crispra crispr interfer crispri crispr base edit crisprb crispr knockdown crisprkd core packag crisprdesign offer user friend unifi interfac add target annot rich gene snp annot target activ score function enabl rna dna target nucleas includ cas cas cas crisprvers ecosystem open sourc deploy bioconductor project https githubcomcrisprvers
D017394;D064113
T123;T040;T114
36,323,687
mental health pregnant individu covid pandem base swiss onlin survey aim studi evalu mental health pregnant individu earli covid pandem potenti factor associ swiss onlin survey propos individu gave birth pandem period march edinburgh postnat depress scale epd general anxieti disord question gad impact event scale revis ie r evalu use defin mental health impair composit outcom octob februari particip respond anxieti gad score moder sever epd moder sever ie r moder sever mental health impair report associ risk mental health impair foreign nation signific ci well fetal pregnanc worri coronavirus ci ci adjust or signific foreign nation aor ci pregnanc worri coronavirus aor ci pregnant peopl especi foreign nation high risk mental health impair pandem
D058873;D000086382
T047;T067
36,323,686
precis phase retriev propag base imag use discret mathemat ill pose problem phase retriev optic use one intens measur multitud applic use electromagnet matter wave mani phase retriev algorithm comput pixel array use discret fourier transform due high comput effici howev mathemat underpin algorithm typic formul use continu mathemat result loss spatial resolut reconstruct imag herein investig phase retriev algorithm propag base phase contrast x ray imag rederiv use discret mathemat result precis retriev singl multi materi object spectral imag decomposit valid theori experiment measur spatial resolut use comput tomographi ct reconstruct plastic phantom biolog tissu use detector rang imag system point spread function psfs demonstr psf substanti suppress high spatial frequenc potenti improv utilis discret deriv limit howev detector characteris singl pixel psf eg direct photon count x ray detector signific improv spatial resolut obtain demonstr
D014057;D000465
T060;T170
36,323,684
kainat receptor subunit grik risk variant grik defici detect indian adhd proband execut dysfunct caus structur function abnorm prefront cortex report patient attent deficit hyperact disord adhd owe higher express glutam ionotrop receptor kainat type subunit gluk encod grik gene brain region respons learn memori hypothes grik might role adhd grik variant rs rs affect receptor function analyz case control famili base method identifi associ adhd impact variant adhd associ trait pharmacolog intervent also analyz grik express quantifi peripher blood proband father higher frequenc rs cc rs ca genotyp famili base investig reveal matern transmiss rs c rs allel proband quantit trait analysi exhibit associ rs tt rs aa genotyp higher hyperact score proband presenc rs tt rs cc genotyp mph treatment improv hyperact inattent respect grik express signific downregul proband infer grik affect adhd etiolog warrant depth investig involv larger cohort function variant
D001289
T048
36,323,683
l threonin promot healthspan expedit ferritin depend ferroptosi inhibit c elegan pathway impact longev wake dietari restrict dr remain still ill defin studi focus nutrient limit perturb energi metabol show l threonin elev caenorhabd elegan dr l threonin supplement increas healthspan use metabol transcriptom profil worm fed rnai induc loss key candid mediat l threonin supplement loss threonin dehydrogenaseincreas healthspan attenu ferroptosi ferritin depend manner transcriptom analysi show ftn encod ferritin elev impli ftn essenti mediat longev promot organism ferritin level posit correl chronolog age l threonin supplement protect age associ ferroptosi daf hsf pathway investig uncov role distinct univers metabolit l threonin dr mediat improv organism healthspan suggest could effect intervent prevent senesc progress age induc ferroptosi
D029742;D000079403
T116;T043
36,323,682
foxa repress drive lineag plastic immun heterogen bladder cancer squamous differenti cancer aris bladder urothelium often exhibit lineag plastic region urotheli carcinoma adjac admix region diverg histomorpholog common squamous differenti defin biolog basi clinic signific morpholog heterogen perform integr genom analys mix histolog bladder cancer separ region urotheli squamous differenti find squamous differenti marker intratumor genom immunolog heterogen patient bladder cancer biomark intrins immunotherapi resist phylogenet analysi confirm case urotheli squamous region deriv common share precursor despit presenc mark genom heterogen co exist urotheli squamous differenti region recurr genom alter exclus urotheli squamous morpholog identifi rather lineag plastic bladder cancer squamous differenti associ loss express foxa gata pparg transcript factor critic mainten urotheli cell ident clinic signific lineag plastic pd l express coordin dysregul via foxa patient exhibit morpholog heterogen pre treatment signific less like respond immun checkpoint inhibitor
D002294;D002295;D001749
T191
36,323,681
systemat analysi predict gene associ monogen disord human chromosom x diseas gene discoveri chromosom chr x challeng owe uniqu mode inherit undertook systemat analysi human chrx gene observ higher proport disord associ gene enrich gene involv cognit languag seizur chrx compar autosom analyz gene constraint exon promot conserv express paralogu report gene share one attribut known chrx disord gene use machin learn classifi train distinguish diseas associ dispens gene classifi gene includ high probabl diseas associ provid evid excess variant predict gene exist databas final report damag variant cdk trpc patient intellectu disabl autism spectrum disord studi predict larg scale gene diseas associ could use priorit x link pathogen variant
D008607;D000067877
T048
36,323,680
errat blood vessel guid migrat astrocyt progenitor cerebr cortex astrocyt one abund cell type mammalian brain play essenti role synaps format matur elimin howev astrocyt migrat gray matter accomplish process poor understood show combin analys vitro vivo time laps observ lineag trace astrocyt progenitor move rapid irregular within develop cortex call errat migrat astrocyt progenitor also adopt blood vessel guid migrat high motil progenitor generat restrict prenat stage differenti protoplasm astrocyt gray matter wherea postnat generat progenitor move extens differenti fibrous astrocyt white matter found cxcr integrin regul blood vessel guid migrat function block disrupt posit studi provid insight astrocyt develop may contribut understand pathogenesi caus defect
D001253;D002540
T023;T029;T025
36,323,677
deep learn empow volum delin whole bodi organ risk acceler radiotherapi radiotherapi cancer patient indispens process delin organ risk oar tumor howev time consum step manual delin alway requir radiat oncologist herein propos lightweight deep learn framework radiotherapi treatment plan rtp name rtp net promot automat rapid precis initi whole bodi oar tumor briefli framework implement cascad coars fine segment adapt modul small larg organ attent mechan organ boundari experi show three merit extens evalu delin task larg scale dataset case demonstr compar superior accuraci averag dice achiev near real time delin task framework could util acceler contour process one radiotherapi scheme thus great shorten turnaround time patient
D000077321;D009369
T191;T066
36,323,676
integr analys reveal evolutionarili conserv specif injuri respons gene dorsal root ganglion rodent dorsal root ganglion drg wide use studi axon injuri extens studi explor genom wide profil rodent drgs peripher nerv insult howev systemat integr explor data still limit herein analyz rna seq dataset present web base resourc drgprofil identifi evolutionarili conserv injuri respons gene includ well known injuri gene atf npi gal less studi transcript factor arida csrnp zfp notabl identifi speci prefer injuri respons candid eg gpr lipn anxa mice crisp csrp vip hamp rat tempor profil analysi reveal express pattern gene relat pre regen regener state final found larg sex differ respons sciatic nerv injuri identifi four male specif marker uti eifsi kdmd ddxi express drg studi provid comprehens integr landscap express chang drg upon injuri great contribut neurosci communiti
D005727;D012584
T023
36,323,674
pure acut erythroid leukemia morpholog immunophenotyp cytogenet mutat treatment detail surviv data among mayo clinic case pure erythroid leukemia pel also known acut erythroid leukemia ael recogn distinct morpholog entiti world health organ classif system contrast intern consensus classif icc includ pel broader categori acut myeloid leukemia mutat tp identifi mayo clinic case pel mean age year rang male provid comprehens account bone marrow morpholog immunophenotyp cytogenet mutat profil pel primari case therapi relat secondari undetermin one case express biallel tp alter includ tp deletionsingl tp mutat two tp mutat two tp delet addit mutat infrequ karyotyp complex case monosom treatment detail avail patient hypomethyl agent hma alon n hma venetoclax n intens chemotherapi n support careoth n respons allogen stem cell transplant document patient die median month rang current studi highlight consist reproduc set morpholog genet characterist identifi pel distinct aml variant whose dismal prognosi requir urgent attent
D004915;D015470
T191
36,323,673
hif dna dna rna triplex form lncrna interact hush complex dna dna rna triplex form hoogsteen base pair rna major groov dna duplex observ vitro extent interact occur cell impact cellular function remain elus use combin bioinformat techniqu rnadna pulldown biophys studi set identifi function import dna dna rna triplex form long non code rnas lncrna human endotheli cell lncrna hif retriev top hit endogen hif reduc express numer gene includ eph receptor adrenomedullin dna dna rna triplex format act adapt repress human silenc hub complex hush moreov oxygen sensit hif regul pulmonari hypertens loss function approach result gene de repress also enhanc angiogen capac exemplifi hif dna dna rna triplex format function import mechan tran act gene express control
D062085
T123;T114
36,323,671
bottom assembl viral replic cycl bottom synthet biolog provid new mean understand live matter construct minim life like system principl also appli studi infecti diseas summar approach ethic consider bottom assembl viral replic cycl
D058615;D014779
T090;T043
36,323,669
enhanc decommiss mll ablat elicit dsrna interferon signal gsdmd mediat pyroptosi potenti anti tumor immun enhanc deregul well establish pro tumorigen mechan whether play regulatori role tumor immun larg unknown demonstr tumor cell ablat mix lineag leukemia mll mll also known kmtc kmtd respect two enhanc associ histon h lysin hk mono methyltransferas increas tumor immunogen promot anti tumor cell respons mechanist mll ablat attenu express rna induc silenc complex risc dna methyltransferas decommiss enhancerssup enhanc consequ lead transcript reactiv doubl strand rna dsrna interferon respons gasdermin gsdmd mediat pyroptosi respect import reveal dsrna interferon signal gsdmd mediat pyroptosi critic import increas anti tumor immun improv immunotherapeut efficaci mll ablat tumor thus find establish tumor cell enhanc addit layer immun evas mechan suggest potenti target enhanc upstream andor downstream molecular pathway overcom immunotherapeut resist cancer patient
D011495;D009369
T191;T126;T116
36,323,668
tempo unsupervis bayesian algorithm circadian phase infer singl cell transcriptom circadian clock h cellular timekeep mechan regul human physiolog answer sever fundament question circadian biolog requir joint measur singl cell circadian phase transcriptom howev widespread experiment approach exist purpos comput approach exist infer cell phase direct singl cell rna sequenc data exist method yield poor circadian phase estim quantifi estim uncertainti essenti interpret result spars singl cell rna sequenc data address unmet need introduc tempo bayesian variat infer approach incorpor domain knowledg clock quantifi phase estim uncertainti simul analys real data demonstr tempo yield accur estim circadian phase exist method provid well calibr uncertainti quantif tempo facilit larg scale studi singl cell circadian transcript
D059467;D057906
T081;T040;T086
36,323,665
cap depend translat initi monitor live cell mrna translat tight regul preserv cellular homeostasi despit extens biochem genet structur studi detail understand mrna translat regul lack imag methodolog abl resolv bind dynam translat factor singl cell singl mrna resolut necessari fulli elucid regul paramount process live cell spectroscopi singl particl track combin interrog bind dynam endogen initi factor cap diffus initi factor if chang mark upon associ mrna quantifi diffus characterist reveal sequenc if assembl disassembl cell line cluster translat neuron approach reveal translat regul high spatial tempor resolut appli format endogen complex result measur shift diffus
D010448;D014176
T123;T116;T044
36,323,663
programm self regul molecular buffer precis sustain drug deliveri unlik artifici nanosystem biolog system ideal engin respond environ natur molecular buffer ensur precis quantit deliveri specif molecul self regul mechan base le chateli principl appli principl design self regul nucleic acid molecular buffer chemotherapeut drug doxorubicin antimalari agent quinin show aptam base buffer program maintain specif desir concentr free drug vitro vivo enabl optim chemic stabil partit coeffici pharmacokinet biodistribut drug programm buffer built polym improv patient therapeut outcom enhanc drug activ minim advers effect dosag frequenc
D004317;D011108
T121;T109;T104;T122;T195
36,323,661
speedingcar acceler engin car cell signal domain shuffl singl cell sequenc chimer antigen receptor car consist antigen bind region fuse intracellular signal domain enabl custom cell respons target despit major role cell activ effector function persist small set immun signal domain explor present speedingcar integr method engin car cell via signal domain shuffl pool function screen leverag inher modular natur signal domain generat librari uniqu car variant genom integr primari human cell crispr cas vitro tumor cell co cultur follow singl cell rna sequenc scrna seq singl cell car sequenc sccar seq enabl high throughput screen identifi sever variant tumor kill properti cell phenotyp mark differ standard car map car scrna seq data onto tumor infiltr lymphocyt help guid select variant result thus help expand car signal domain combin space support speedingcar tool engin car potenti therapeut develop
D000076962;D009369
T129;T191;T116;T192
36,323,660
myc promot immun suppress tripl negat breast cancer via inhibit interferon signal limit efficaci immun checkpoint inhibitor treatment tripl negat breast cancer tnbc patient attribut spars unrespons tumor infiltr lymphocyt mechan lead therapi resist tumor immun microenviron incomplet known show strong correl myc express loss immun signatur human tnbc mous model tnbc profici defici breast cancer type suscept gene brca myc overexpress dramat decreas lymphocyt infiltr tumor along immun signatur remodel myc mediat suppress inflammatori signal induc brca inactiv confirm human tnbc cell line moreov myc overexpress prevent recruit activ lymphocyt human mous tnbc co cultur model chromatin immunoprecipit sequenc reveal myc togeth co repressor miz direct bind promot multipl interferon signal gene result downregul myc overexpress thus counter tumor growth inhibit stimul interferon gene sting agonist via suppress induct interferon signal togeth data reveal myc suppress innat immun facilit tumor immun escap explain poor immunogen myc overexpress tnbcs
D064726
T191
36,323,658
network motif shape distinct function earth moistur recycl hub earth hydrolog cycl critic depend atmospher moistur flow connect evapor precipit convert decad reanalysi base moistur simul high resolut global direct network spatial moistur provis reveal global local network structur offer new view global hydrolog cycl identifi four terrestri moistur recycl hub amazon basin congo rainforest south asia indonesian archipelago network motif reveal contrast function region amazon strong reli direct connect feed forward loop moistur redistribut hub reciproc moistur connect zero loop neighbor loop conclud earth moistur recycl hub character specif topolog shape heterogen effect land use chang climat warm precipit pattern
D065947;D058438
T070;T067
36,323,657
structur dynam dna strand break sens parp singl molecul level singl strand break ssbs frequent dna lesion threaten genom integr high kink dna structur complex human parp domain led propos ssb sens eukaryot reli dynam broken dna doubl helix parp multi domain organ direct probe process singl molecul level quantit smfret structur ensembl calcul reveal parp n termin zinc finger convert dna ssbs larg unperturb conform via intermedi state high kink dna conform data suggest induc fit mechan via multi domain assembl cascad drive ssb sens stimul interplay scaffold protein xrcc orchestr subsequ dna repair event interest clinic use parp inhibitor niraparib shift equilibrium toward unkink dna conform wherea inhibitor eb stabil kink state
D000067856;D053904
T121;T049
36,323,656
uncertainti inform deep learn model enabl high confid predict digit histopatholog model abil express predict uncertainti essenti attribut maintain clinic user confid comput biomark deploy real world medic set domain cancer digit histopatholog describ clinic orient approach uncertainti quantif whole slide imag estim uncertainti use dropout calcul threshold train data establish cutoff low high confid predict train model identifi lung adenocarcinoma vs squamous cell carcinoma show high confid predict outperform predict without uncertainti cross valid test two larg extern dataset span multipl institut test strategi close approxim real world applic predict generat unsupervis unannot slide use predetermin threshold furthermor show uncertainti threshold remain reliabl set domain shift accur high confid predict adenocarcinoma vs squamous cell carcinoma distribut non lung cancer cohort
D000077321;D000230;D002294
T191;T066
36,323,586
research progress mesenchym stem cell treatment diabet bladder dysfunct diabet bladder dysfunct dbd common complic lower urinari tract diabet recent year mesenchym stem cell msc broad applic prospect treatment dbd msc migrat damag bladder tissu differenti various cell type urotheli cell myofibroblast smooth muscl cell nerv cell promot bladder tissu repair regener paracrin effect addit msc also interven patholog process dbd revers diseas progress restor partial bladder function immun regul improv oxid stress regul blood glucos present treatment dbd msc limit preclin anim experi clinic research applic pursu
D059630;D003920
T047;T025
36,323,585
applic branch first techniqu total thorac aorta replac short medium term effect case object examin short medium term effect branch first techniqu total thorac aorta replac method clinic data eleven patient ascend aortic aneurysm type aortic dissectioncrawford total thoracoabdomin aortic aneurysm treat depart cardiovascular surgeri henan provinc chest hospit januari juli retrospect analyz male femal age year rang year case diagnos marfan syndrom case diagnos coarctat aorta oper perform mild hypotherm branch first techniqu first middl small incis chest combin th intercost incis left posterior later side second four branch artifici blood vessel anastomos brachiocephal arteri ensur blood suppli brain circul block intracardiac aortic proxim oper perform intercost arteri reconstruct thorac descend aorta replac complet open circul result oper time group minut rang minut one case cerebr infarct case chylothorax patient follow month patient underw thorac abdomin aortailiac arteri resect replac due progress abdomin aortic aneurysm month oper intercost arteri obstruct occur case rest live well conclus one stage whole thorac aorta replac branch first techniqu satisfactori result short medium term risk residu aortic aneurysm ruptur effect treatment young organ function well patient complex aortic lesion
D017545;D000784;D019917
T061;T047;T046
36,323,584
free anterolater thigh myocutan flap combin pedicl latissimus dorsi myocutan flap transfer function reconstruct resect huge shoulder tumor object investig method effect free anterolater thigh myocutan flap combin pedicl latissimus dorsi myocutan flap transfer function reconstruct resect huge shoulder tumor method clinic data patient treat pedicl latissimus dorsi myocutan flap combin free anterolater thigh myocutan flap repair larg area complex defect shoulder tumor resect depart oncolog plastic surgeri hunan provinc cancer hospit decemb decemb retrospect analyz male femal averag age year rang year case synovi sarcoma case phylloid cell sarcoma case liposarcoma case fibrosarcoma oper tumor resect perform time case cours diseas month pedicl latissimus dorsi myocutan flap combin free anterolater thigh myocutan flap use repair soft tissu defect reconstruct deltoid function postop flap status complic appear function upper limb tumor recurr record result six patient follow averag month rang month serious complic oper flap surviv tumor recurr found appear shoulder contour reconstruct flap satisfactori reinnerv effect later femor muscl confirm recov smooth neuroelectromyographi month oper shoulder function mild limit patient moder limit patient sever limit patient patient report signific improv shoulder discomfortth overal function result patient satisfactori conclus combin myocutan flap transplant perfect repair wound left resect huge shoulder tumor minim recurr tumor reconstruct function shoulder joint great improv qualiti life patient
D064827;D064171;D019651;D016462;D012509;D017695
T061;T024;T191;T037;T023
36,323,583
compar studi imag clinic result patellofemor joint kinemat align mechan align total knee arthroplasti object investig chang imag paramet patellofemor joint kinemat align total knee arthroplasti ka tka mechan align total knee arthroplasti tka effect clinic outcom method retrospect analysi perform patient diagnos knee osteoarthr male femal age year rang year patient underw unilater tka depart orthopaed surgeri beij chaoyang hospit capit medic univers januari juli patient divid ka tka group n tka group n accord align method blackburn peel index later patellofemor angl patellofemor tilt angl patellofemor index two group record month oper frequenc later patellar retinaculum releas preoper postop knee rang motion rom oxford knee score ok also record differ preoper postop measur data group calcul differ line normal distribut independ sampl test test use comparison two group conform normal distribut mann whitney u test use pair sampl test use comparison treatment chi squar test use compar categor data two group result month oper patellar tilt angl ka tka group tka group later patellar angl respect chang later patellofemor angl ka tka group signific less tka group vs p ok rom improv group month oper p intraop later patellar retinacular releas rate tka group ka tka group statist differ p conclus greater patella later tilt month postop ka tka group compar tka group radiograph differ could show differ clinic outcom postop rom frequenc intraop later patellar retinacular releas would nt increas therefor ka tka increas difficulti postop patellofemor joint complic intraop later patellar releas
D019645;D057071;D020370;D007720
T061;T047;T074;T030
36,323,582
landscap metastas lymph node prostat anterior fat pad radic prostatectomi object examin landscap metastas lymph node prostat anterior fat pad pafp radic prostatectomi rp describ clinic characterist patient lymph node metastas pafp method clinic patholog data prostat cancer patient underw rp decemb august depart urolog sun yat sen univers cancer center collect analyz retrospect patient male age year rang year preoper prostat specif antigen psa iqr gl rang gl patient local local advanc prostat cancer patient metastat prostat cancer pafp dissect rp routin sent patholog analysi respect pafp dissect prostat apex caudal toward bladder neck dissect extend joint prostat endopelv fascia bilater specimen pafp examin report subspecialti pathologist genitourinari tumor statist analysi perform student test wilcoxon rank sum test test fisher exact test result patient lymph node pafp patient pafp lymph node metastas patholog upstag occur patient due pafp lymph node solitari metastat lesion patient lymph node metastas pafp present higher preoper psa iqr gl vs gl z p clinic stage n stage z p z p preoper gleason score z p conclus routin dissect pafp rp separ patholog analysi may allow lymph node lymph node metastas detect accur patholog n stage may acquir consequ may improv surviv patient offer appropri adjuv salvag therapi
D011467;D011471
T023;T191
36,323,581
clinic analysi three dimension surgic plan system guid robot assist select arteri clamp partial nephrectomi complet endophyt renal tumor object examin safeti feasibl three dimension surgic plan system guid robot assist select arteri clamp partial nephrectomi raspn complet endophyt renal tumor method clinic data patient suffer complet endophyt renal tumor underw raspn associ surgic plan system depart urolog sun yat sen univers cancer center novemb august analyz retrospect male femal age iqr year rang year fifteen tumor locat left right maximum tumor diamet renal score preoper estim glomerular filtrat rate egfr mm rang mm rang mlmin rang mlmin respect reconstruct raspn perform patient formul surgic plan main includ stereo local renal mass confirm tumor feed arteri injuri predict collect system vessel via mm distanc method defin probabl damag renal pelviscalyx arteryvein tissu less mm away tumor result total patient success underw raspn guid surgic plan system without convers open oper radic nephrectomi rapid locat tumor select clamp arteri achiev case one encount global ischemia branch occlus time min rang min coincid rate plan actual clamp vessel sensit specif mm distanc method predict injuri collect system respect oper time minuet rang minut estim blood loss ml rang ml observ without intraop transfus case one patient perform renal vein repair clavien dindo postop grade bleed complic occur case postop urinari fistula found length hospit day rang day patholog diagnosi demonstr chromophob cell carcinoma angiomyolipoma besid clear cell carcinoma includ one posit surgic margin postop latest egfr mlmin rang mlmin tumor recurr metastasi detect follow time month rang month conclus raspn complet endophyt renal tumor surgic plan system contribut determin mass posit defin tumor feed arteri predict collect systemvessel injuri benefit precis tumor resect postop renal function preserv periop urinari fistula bleed complic decreas
D012371;D007680;D065287;D010535;D014548;D002277
T061;T090;T060;T191;T047
36,323,580
risk factor distal aorta negat remodel endovascular aortic repair type b dissect recent year great progress made treatment stanford type b aortic dissect especi endovascular repair technolog becom main treatment howev use repair primari tear residu tear fals lumen often left distal end caus advers event distal aortic dilat even ruptur present mani studi influenc factor aortic remodel provid refer prognosi patientsth aorta carri transport blood flow various factor affect hemodynam also affect remodel aorta research report sever factor relat negat remodel ad auxiliari techniqu achiev gratifi result howev differ condit patient specif treatment method still unclear factor affect aortic remodel effect also thorough studi clarifi influenc factor negat remodel help screen high risk patient optim treatment plan improv prognosi
D017545;D019917;D057510
T061;T047
36,323,579
urethroplasti technolog chang treatment male urethr strictur urethroplasti import method treat male urethr strictur nowaday urethroplasti main includ two type anastomot urethroplasti substitut urethroplasti anastomot urethroplasti main includ primari anastomosi urethroplasti non transect anastomot urethroplasti substitut urethroplasti main includ stage urethroplasti one stage urethroplasti substitut materi alway chosen pedicl skin flap free mucos graft anastomosi urethroplasti shown good result short bulbar urethr strictur posterior urethr strictur pelvic fractur among non transect anastomosi urethroplasti becom new surgic method iatrogen singl short non occlud stenosi present one stage substitut urethroplasti wide use howev still mani complic case must solv stage urethroplasti pedicl skin flap oral mucosa wide use substitut present select best surgic procedur substitut materi individu would problem worthi attent futur accumul long term follow data help object comparison various surgic procedur graft
D014525;D013521
T061;T047;T190
36,323,578
trend earli precis diagnosi treatment strategi multipl endocrin neoplasia type multipl endocrin neoplasia type men autosom domin hereditari neuroendocrin cancer syndrom character medullari thyroid carcinoma combin pheochromocytoma hyperparathyroid extra endocrin featur two form subtyp mena menb base correl ret proto oncogen mutat men phenotyp men could prevent prenat diagnosi preimplant genet test integr detect ret mutat measur serum calcitonin plasma urinari metanephrinenormetanephrin serum parathyroid hormon level could accur predict progress men facilit implement person precis treatment addit increas awar men need requir particip physician patientsfamili member relev organ supplement psycholog support could promot comprehens manag men p strategi men repres paradigm precis medicin could effect avoid reduc clinic advers outcom improv prognosi qualiti life men patient
D018813;D013964;D000310
T191
36,323,577
explor think function preserv orthotop neobladd construct concept function preserv orthotop neobladd construct gradual attract attent reconstruct urin storag void basic function preserv orthotop neobladd clinic explor main focus optim neobladd reconstruct method procedur still lack summari exist surgic characterist high qualiti function compar studi strict select patient basi tumor control standard postop rehabilit guidanc patient preserv nerv retain satisfi sexual function surgeri protect neurovascular bundl ancillari structur combin postop exercis crucial improv urinari contin accord characterist patient choos appropri urinari divers method function preserv help patient establish normal life style surgeri improv self imag qualiti life
D016476;D001749;D014547
T061;T017;T191
36,323,576
consensus clinic diagnosi treatment fumar hydratas defici renal cell carcinoma fumar hydratas defici renal cell carcinoma fh rcc independ patholog subtyp renal cell carcinoma clear driver gene high degre malign recent studi found patient somat fh mutat similar clinico biolog behavior poor prognosi patient germlin fh mutat fh rcc characterist earli age onset atyp imag manifest variabl patholog pattern difficult clinic diagnosi poor effect tradit drug treatment thus great endang life health patient organ rare kidney cancer collabor group genitourinari cancer committe china anti cancer associ guidelin develop base basic research clinic cohort evid base medicin evid includ imag manifest patholog diagnosi genet test surgic system treatment option provid recommend refer diagnosi treatment norm
D002292;D007680
T191
36,323,575
research progress protein metabol syndrom
D024821;D007333
T047;T046
36,323,574
research progress acth stimul test mg dexamethason suppress test determin subtyp primari aldosteron papapapapapaavsavspaacth mgacthpapa
D006929
T047
36,323,573
research progress pericardi diseas associ immun checkpoint inhibitor iciiciici
D000082082;D006331
T129;T047;T121;T043
36,323,572
research progress cerebrospin fluid blood biomark multipl system atrophi multipl system atrophymsa synuclein synmsamsamsamsamsamsa
D019578
T046
36,323,571
applic clinic decis support system gastrointestin diseas artifici intelligenceaiclin decis support systemcdssaicdss
D020000;D005767
T058;T170;T047
36,323,570
situ recurr sacral metastasi surgeri case adren pheochromocytoma ct
D010673;D000310
T191
36,323,569
case adult abdomin migrain recurr abdomin pain nausea vomit ct
D009325;D008881
T184;T047
36,323,568
case type insulin resist syndrom aa
D007333;D003920;D024821;D003924
T047;T046
36,323,567
studi burden myocard china object investig chines myocard burden trend method base global burden diseas gbd data number patient number new case number death disabl adjust life year dali well morbid mortal dali rate age standard rate use analyz trend burden myocard chines popul result number patient number new case number death myocard china respect increas compar age standard incid mortal respect compar age standard incid decreas mortal decreas respect age standard incid mortal chines male patient myocard higher femal compar age group largest incid mortal myocard china shift elder group dali age normal dali due myocard china show decreas trend respect rate dali age standard dali male patient alway higher femal conclus compar overal burden myocard china show downward trend burden myocard male patient higher femal attent paid burden myocard chines elder popul
D009205
T047
36,323,566
associ serum sex hormon bind globulin non alcohol steatohepat object investig associ serum sex hormon bind globulin shbg non alcohol steatohepat nash method cross section studi total middl age young obes patient hospit underw liver punctur nanj drum tower hospit januari april includ popul divid control group n non alcohol fatti liver diseas nafld group n base non alcohol fatti liver diseas activ score subject nafld group divid non alcohol fatti liver nafl n uncertain nash n nash n serum shbg test patient nafld divid three subgroup accord tertil liver patholog characterist differ shbg level subgroup compar risk factor nash analyz logist regress predict model nash noninvas diagnosi establish forward stepwis regress diagnost valu non invas model nash evalu receiv oper characterist roc curv result median age patient year old bodi mass index kgm includ femal serum shbg level q q nafld group signific lower control group vs mmoll p progress diminish nafl uncertain nash nash subgroup mmol p trend compar high level shbg subgroup steatosi score vs p lobular inflamm score vs p signific higher low level shbg group multivari logist regress analysi indic lower serum shbg level independ risk factor nash ci p area roc curv shbg combin aspart aminotransferas predict nash nafld patient ci conclus low serum shbg level associ nash
D065626
T047
36,323,565
correl glycem variabl glycosyl hemoglobin level follow elder male patient type diabet beij object investig relationship glycem variabl glycosyl hemoglobin hbac level follow elder male patient type diabet method retrospect cohort studi total elder male patient receiv continu glucos monitor januari januari recruit second medic center pla general hospit subject divid two group accord baselin mean amplitud glycaem excurs mage level includ mage mmoll group n mage mmoll group n correl baselin mage mean hbac follow evalu univari pearson correl analysi multivari linear regress analysi result baselin characterist includ age bodi mass index waist circumfer smoke drink fast blood glucos blood lipid blood pressur compar mage mmoll group mage mmoll group averag follow period year mean hbac follow mage mmoll group signific higher mage mmoll group vs p proport mean hbac follow mage mmoll group signific lower mage mmoll group p univari analysi mage baselin correl mean hbac follow r p multivari linear regress analysi suggest baselin mage remain independ influenti factor mean hbac ci p r sever confound factor adjust conclus increas glycem variabl baselin mean hbac level follow accord elev glycem variabl baselin independ relat mean hbac level follow elder male patient type diabet
D001786;D003924
T047;T109
36,323,564
preliminari studi express mif hcc tissu relationship erk signal pathway object investig express macrophag migrat inhibitori factor mif hepatocellular carcinoma hcc tissu interact erk signal pathway establish theoret basi studi molecular mechan mif promot hcc method februari august case hepatocellular carcinoma hcc tissu base hepat b cirrhosi hbv lc case adjac tissu tianjin medic univers cancer hospit th hospit joint logist support forc pla collect experiment group includ male femal age year case normal liver tissu select control group immunohistochemistri use detect express mif erk p erk protein liver tissu two group situ hybrid use detect express erk nucleic acid liver tissu two groupshepg hcc cell l normal hepatocyt co cultur differ concentr rmif express phosphoryl level erk jnk protein two kind liver cell detect western blot express level erk nucleic acid two kind liver cell detect rt pcr one way anova use measur data test use count data result express mif erk p erk erk mrna signific increas hcc para cancer tissu express mif hcc group adjac group erk hcc group erk paracancer group express p erk hcc group paracancer group respect detect erk mrna express hcc group erk mrna express paracancer group differ statist signific compar normal liver tissu p express erk p erk erk mrna hepg hcc cell signific increas increas rmif concentr increas obvious rmif concentr ngml differ statist signific compar l normal hepatocyt p conclus mif erk p erk high express hcc tissu hepg hcc cell suggest mif promot occurr develop hepatocellular carcinoma erk signal pathway
D006528;D008113;D008263
T129;T123;T191;T116
36,323,563
expert consensus applic manag antibiot liver tumor ablat version ablat becom import effect treatment liver malign applic technolog becom extens detail relat complic collect consequ infect ablat serious therefor necessari manag periop period popul risk factor infect well especi ration use antibiot view current situat organ domest expert discuss draw expert consensus applic manag antibiot liver tumor ablat
D008113;D017115
T061;T191
36,323,562
recommend diagnosi treatment connect tissu diseas associ interstiti lung diseas china interstiti lung diseas ild frequent complic patient connect tissu diseas ctd signific affect morbid mortal diseas cours may vari stabl mild progress sever rapid loss lung function present great challeng poor prognosi diagnosi treatment ctd ild base evid guidelin china countri expert chines rheumatolog associ develop standard diagnosi treatment ctd ild aim strengthen earli identif standard diagnosi treatment ctd ild delay progress diseas
D003240;D017563
T047
36,323,561
recommend diagnosi treatment connect tissu diseas associ pulmonari arteri hypertens china pulmonari arteri hypertens pah clinicopatholog syndrom caus increas pulmonari arteri serious complic connect tissu diseas ctd recent year lot progress made diagnosi treatment evalu pah chines rheumatolog associ formul recommend basi current experi guidelin order promot earli screen earli diagnosi earli intervent ctd pah well patient follow manag improv prognosi ctd pah patient
D000081029;D006976;D003240
T047;T046
36,323,560
chines guidelin manag pregnanc reproduct patient system lupus erythemat system lupus erythematosus sle autoimmun diseas affect women childbear age improv diagnosi treatment surviv rate sle patient improv signific pregnanc still import challeng sle patient urgent strengthen reproduct pregnanc manag sle patient standard peri gestat monitor treatment sle patient guidelin joint sponsor nation clinic research center dermatolog immunolog diseas ncrc chines system lupus erythematosus treatment research group cstar chines research committe pregnanc reproduct autoimmun rheumat diseas chopard guid clinic problem sever round clinic methodolog expert demonstr select clinic problem need solv final form base evid base medic evid expert opinion guidelin recommend given aim improv pregnanc success rate reduc matern infant mortal rate sle patient
D008180;D011248
T047;T046
36,323,559
stress influenc sleep cardiovascular health
D012890;D006321
T033;T023;T040
36,323,558
imper establish treatment center long term mechan ventil china icuicu
D012121
T061
36,323,557
patholog pathogenesi hiv encephalopathi acquir immunodefici syndromeaidscd
D015526;D015658
T047
36,323,556
amyloid arthropathi carpal tunnel syndrom report case kappakappalambda
D002349;D000686;D007592
T047
36,323,555
high grade endometri carcinoma choriocarcinoma differenti report case ctppaxpwtgatapsallmucaridapikrmreatpsmarcarnf
D002822;D016889
T191
36,323,554
revers variant follicular lymphoma report case revers variant follicular lymphomarvfl
D008224
T191
36,323,553
fatal macrofollicular variant papillari thyroid carcinoma report case pet ct
D002291;D013964
T191
36,323,552
atyp teratoidrhabdoid tumor adult patient report two case
D018335;D013724;D008527;D016543;D002528;D001932
T191
36,323,551
applic methylen blue counterstain immunohistochem stain melanoma tumor tissu envisionmelan ahmb sox ki dab p melan ahmb ki sox dab p dab
D008751;D008545
T121;T191;T130;T109
36,323,550
isol myeloid sarcoma cervix clinicopatholog analysi three case cdcdcd
D023981;D002583
T191
36,323,549
adenoid cystic carcinoma cervix clinicopatholog analysi five case adenoid cystic carcinomaacc accmybhpvdna accacchsilcinbaacc abchsilcinaccacccdp acdphpv dna pcrhpv dnamyb accaccmybacchpv
D003528;D002583
T191
36,323,548
clinicopatholog studi gaucher diseas cdcdcdcdccdcdhla drki
D005776
T047
36,323,547
clinicopatholog characterist pax posit anaplast larg cell lymphoma extra copi pax gene locus paxalcl paxalcl r scdcdcdcdpaxcdcdcdcdcdbttiaalkebrnaeberttcrigpaxighpaxchoep paxalclpax
D017728
T191
36,323,546
intracrani mesenchym tumor ewsr creb fusion posit clinicopatholog studi three case fet creb fet creb cdcdd ki ewsr crebewsr crem fet crebewsr
D051677
T191
36,323,545
complic lymphat anomali clinicopatholog analysi four case object investig clinicopatholog featur clinic manifest differ diagnosi patient complic lymphat anomali method clinic patholog data four patient complic lymphat anomali diagnos treat peke union medic colleg hospit januari decemb collect analyz result one gorham stout diseas case three general lymphat anomali case includ cohort patient age rang year three male one femal posit biopsi includ three bone biopsi one bronchus biopsi microscop case show diffus enlarg lymphat channel time osteogenesi obvious gorham stout diseas case radiolog cortic loss seen gorham stout diseas lytic bone confin medullari caviti present general lymphat anomali three general lymphat anomali case also coagulopathi two effus conclus histolog featur complic lymphat anomali diffus lymphat malform diagnosi depend clinic patholog inform treatment prognosi diseas differ therefor necessari understand clinic patholog featur make correct diagnosi
D010015;D044148
T047;T190
36,323,544
cic rearrang sarcoma rhabdoid featur clinicopatholog analysi object investig histopatholog immunohistochem molecular genet characterist cic rearrang sarcoma crs rhabdoid featur method clinic patholog data two case crs diagnos depart patholog jiangsu provinc hospit analyz immunohistochem studi fluoresc situ hybrid fish perform relev literatur review result patient femal one year old tumor locat left thigh year old tumor locat left pelvic caviti microscop tumor compos small medium size round oval cell arrang nodul sheet tumor cell show irregular nuclear outlin coars chromatin promin nucleoli brisk mitot activ case show rhabdoid phenotyp myxoid stromal chang immunohistochem case posit cd c myc high wt reactiv seen classic area low reactiv rhabdoid area ini lost case negat nkx nkx fish case demonstr convinc break apart signal cic gene one patient die diseas month die diseas month conclus crs small round cell undifferenti sarcoma bone soft tissu defin molecular genet characterist may show atyp morpholog immunophenotyp characterist rhabdoid featur correct understand rare morpholog immunophenotyp characterist combin molecular patholog detect conduc correct diagnosi
D012509;D018228
T191
36,323,543
mutat featur immunoglobulin heavi chain variabl region gene patient chronic lymphocyt leukemia object investig mutat featur immunoglobulin heavi chain variabl region ighv gene patient chronic lymphocyt leukemia cll use immunophenotyp molecular genet method method laboratori result cll patient underw ighv gene examin sino us diagnost laboratori februari februari analyz igvh mutat status presenc specif igvh fragment addit immunophenotyp molecular chromosom karyotyp fish profil investig correl igvh mutat status result among patient male femal media age year year patient mutat ighv ighv unmut ighv un ighv associ vh famili presenc gene fragment overal incid vh famili includ vh famili vh famili vh famili among proport vh vh vh vh vh vh occur un ighv p addit express rate cd vs cdb q delet higher un ighv singl trisomi common found ighv p myd one major mutat gene ighv atm highest mutat rate un ighv conclus cll patient differenti express term ighv gene mutat correl immunophenotyp genet characterist
D015451
T191
36,323,542
clinicopatholog molecular featur multinodular vacuol neuron tumor cerebrum object investig clinicopatholog featur multinodular vacuolar neurodegen tumor mvnt cerebrum investig immunophenotyp molecular characterist prognosi method four case collect general hospit southern theater command guangzhou china one case collect first peopl hospit huizhou china clinic histolog immunohistochem molecular characterist five case analyz follow carri evalu prognos result four femal one male averag age year rang year four patient present seizur one present discomfort head pre oper imag demonstr non enhanc hyperintens multinodular lesion deep cortex superfici white matter frontal n tempor lobe n microscop tumor cell most arrang discret coalesc nodul primarili within deep cortic ribbon superfici subcort white matter tumor compos larg cell ganglion morpholog vesicular nuclei promin nucleoli amphophil light basophil cytoplasm exhibit vari degre matrix vacuol vacuol tumor cell show overt cellular atypia mitot activ immunohistochem tumor cell exhibit widespread nuclear stain huchud neuron antigen sox olig express neuron marker includ synaptophysin neurofila map patchi absent tumor cell negat neun gfap p hkm idh rh atrx brg ini braf aberr molecular chang identifi case case use next generat sequenc includ gene relat diagnosi prognosi central nervous system tumor patient underw complet substanti tumor excis without adjuv chemoradiotherapi post oper follow inform interv month year avail five patient patient free recurr conclus mvnt indol tumor most affect adult support classifi mvnt grade tumor recurr even patient treat subtot surgic excis mvnts may consid observ non surgic treatment asymptomat
D001932;D054022
T023;T191
36,323,541
express cation chlorid cotransport nkcckcc brain tissu children focal cortic dysplasia type object investig express cation chlorid cotransport nkcckcc neuron cerebr lesion children focal cortic dysplasia fcd type provid morpholog basi reveal possibl mechan epilepsi method eight case fcd type diagnos beij haidian hospit beij china case diagnos xuanwu hospit capit medic univers beij china februari decemb includ express nkcc kcc fcd type fcd type b detect use immunohistochemistri doubl immunohistochem stain averag optic densiti nkcc dysmorph neuron normal neuron also determin use immunohistochem stain fcd type case result patient younger year age ten case classifi fcd type iia case fcd type b nkcc express cytoplasm normal cerebr cortex neuron kcc express cell membran dysmorph neuron fcd type express nkcc increas statist higher normal neuron p aberr express kcc dysmorph neuron also note cytoplasm fcd b type express pattern nkcckcc dysmorph neuron fcd type aberr express nkcc balloon cell negat weak posit cell membran aberr express kcc absent conclus express pattern nkcckcc dysmorph neuron balloon cell complet differ normal neuron nkcckcc protein express chang may affect transmembran chlorid flow neuron modifi effect inhibitori neurotransmitt aminobutyr acid increas neuron excit effect may relat occurr clinic epilept symptom
D004827;D065703;D027981
T123;T116;T033;T019;T047
36,323,540
clinicopatholog characterist hk alter diffus midlin glioma evalu ntrk therapeut target object investig clinicopatholog characterist hk alter diffus midlin glioma dmg analyz dmg prognost factor subsequ studi possibl use ntrk therapeut target dmg method total dmg diagnos sanbo brain hospit capit medic univers beij china juli march collect clinic radiolog patholog featur ratio mgmt promot methyl express ntrk characterist ntrk gene fusion analyz prognost valu differ factor also studi includ age tumor locat histolog grade gene protein express ntrk postop adjuv therapi result among dmg case patient primari relaps tumor record thus total patient analyz includ male femal adult year age children year age notabl frequent locat thalamus adult brainstem children lesion show hypointens isointens hyperintens howev contrast enhanc pattern tumor vari mani tumor lack contrast enhanc histolog grade includ grade grade grade two hundr twenti four dmgs diffus posit hkm negat hkme ratio mgmt promot methyl low one hundr seventi seven case posit ntrk fifti case analyz use fluoresc situ hybrid among five dmgs posit rate ntrk fusion posit studi show differ adult pediatr dmgs histolog grade express ntrk ntrk gene fusion one hundr fifti nine patient includ follow analysi p follow period patient die diseas median surviv time month rang month univari log rank analysi show age locat surgic procedur postop adjuv therapi associ overal surviv dmg patient p conclus prognosi dmg poor overal differ adult pediatr dmgs anatom locat prognosi featur ntrk gene fusion detect tumor suggest trk inhibitor might choic treat dmg
D005910
T191
36,323,539
expert consensus patholog evalu endometri carcinoma conserv therapi
D016889;D018269
T191
36,323,538
consensus standard sampl patholog diagnosi pancreat epitheli neoplasm
D010190;D009375
T191
36,323,537
chines expert consensus clinic practic met detect non small cell lung cancer non small cell lung cancernsclcmetmet alterationmetmet metmetmetmetnsclcmet met nsclcmet metmetnsclc mettyrosin kinas inhibitortki tki metnsclc metmetmetmetmetmetmetmet metmetmet
D002289;D008175
T191
36,323,536
introduct pediatr type diffus low grade glioma classif tumor central nervous system th edit whomybmyblmapk
D005910;D001932;D016543
T191
36,323,535
introduct glioneuron neuron tumor classif tumor central nervous system th edit
D018303;D016543;D001932
T191
36,323,534
introduct embryon tumor classif tumor central nervous system th edit whocn embryon tumourscetcetwntshhtptpshh wntshhcet
D009373;D016543
T191
36,323,527
gold nanoparticl design rna compact rna base therapeut hold great promis treat varieti diseas howev doubl strand rnas dsrnas inher unstabl high charg stiff macromolecul requir deliveri vehicl cation ligand function gold nanoparticl aunp abl compact nucleic acid assist rna deliveri use larg scale atom molecular dynam simul show correl ligand length metal core size ligand excess free volum control abil nanoparticl bend dsrna far persist length analysi ammonium bind site show longer ligand bind deep within major groov caus bend limit ligand length thus excess free volum design nanoparticl control intern bind rna major groov nps abl induc rna bend caus period variat rna major groov width densiti function theori studi smaller model support larg scale simul result expect signific implic packag nucleic acid applic nanotechnolog gene deliveri
D053768;D009696
T123;T073;T114
36,323,511
senesc like blood lymphocyt diseas progress amyotroph later sclerosi age known exacerb neuroinflamm neurodegen disord amyotroph later sclerosi al older age associ wors prognosi previous shown activ cell senesc pathway proteom peripher blood mononuclear cell increas proinflammatori cytokin blood individu live al singl center retrospect studi investig express senesc like blood mononuclear cell al
D000690
T047
36,323,490
biomark predict risk venous thromboembol patient rheumatoid arthriti receiv tofacitinib tumour necrosi factor inhibitor oral oral rheumatoid arthriti trial surveil studi patient rheumatoid arthriti age year addit cardiovascular risk factor incid pulmonari embol higher tofacitinib mg two time per day tumour necrosi factor inhibitor tnfi exploratori post hoc analysi examin whether biomark explain associ tofacitinib versus tnfi venous thromboembol vte
D054556;D018501;D001172
T121;T047
36,323,488
systemat literatur review inform eular recommend screen prophylaxi chronic opportunist infect adult autoimmun inflammatori rheumat diseas conduct systemat literatur review slr screen prophylaxi opportunist chronic infect autoimmun inflammatori rheumat diseas aiird
D000086382;D018501;D009894;D012216
T121;T047;T067
36,323,487
evalu diseas activ index psoriat arthriti dapsa quick quantit c reactiv protein assay q dapsa patient psoriat arthriti prospect multicentr cross section studi studi aim evalu diseas activ index psoriat arthriti dapsa base quick quantit c reactiv protein qcrp assay q dapsa multicentr prospect cross section studi patient psoriat arthriti psa
D015535
T047
36,323,485
normal percentil refer curv skin ultrasound thick stiff rodnan site primari object establish preliminari normal refer curv ultrasound dermal thick skin stiff rodnan skin site consid effect gender age measur exploratori object investig effect bodi mass index menopaus skin ultrasound measur
D054459
T060
36,323,484
identif patient relat healthcar relat knowledg relat factor associ inadequ blood pressur control outpati cross section studi serbia determin rate blood pressur bp control analys patient relat medic relat healthcar system relat factor associ poor bp control outpati hypertens ht
D000959;D006973
T121;T047
36,323,483
effect subacromi inject rotat cuff lesion systemat review meta analysi protocol subacromi inject therapeut option rotat cuff injuri consist result well establish yet drug appli object systemat review meta analysi analys effect substanc use subacromi inject treatment rotat cuff injuri shoulder imping syndrom consid function gain pain improv shoulder
D000070636;D019534
T033;T047;T037
36,323,482
studi protocol randomis control trial e health step care approach treatment internet use disord versus placebo condit scapit studi excess internet use lead problem individu introduc game disord intern classif diseas icd previous research shown internet applic caus serious mental health problem well import provid measur prevent earli intervent therapi internet use disord iud
D015928;D062405;D017216
T061;T058
36,323,481
clinic outcom autom versus continu ambulatori periton dialysi end stage kidney diseas protocol systemat review meta analysi increas number studi compar autom periton dialysi apd continu ambulatori periton dialysi capd clinic outcom publish sinc public systemat review meta analysi includ three randomis control trial conduct systemat review meta analysi explor clinic outcom apd versus capd end stage kidney diseas
D010531;D010530;D007676
T061;T047
36,323,480
associ sociodemograph behaviour paramet child develop depend age sex cross section analysi explor environment individu factor associ child develop investig whether strength associ differ accord age children
D002657;D050177
T033;T039;T040
36,323,479
influenc matern bodi mass index human milk composit associ infant metabol gut colonis mainhealth studi protocol observ birth cohort human milk provid macronutri growth bioactiv compound micro organ immunolog compon potenti interact prime infant growth develop immun respons gut microbiota new born infant overweight mother like becom overweight later life overweight relat gut microbiom therefor import investig mother milk infant triad biolog system matern weight status influenc human milk composit infant metabol gut microbiom
D000069196;D008895
T007;T001;T031
36,323,478
mediat role emot labour strategi associ patientvisitor incivil nurs fatigu cross section studi fatigu common problem among nurs patientvisitor incivil thought lead nurs fatigu howev mechan patientvisitor incivil lead nurs fatigu well studi aim studi examin whether associ patientvisitor incivil fatigu among chines nurs mediat emot labour strategi
D000075282;D009726;D009741
T097;T054
36,323,477
covid pandem interim foundat year post confid core skill compet longitudin survey interim foundat year fiy post creat respons covid pandem help bolster workforc manag increas clinic pressur studi aim assess impact fiy post medic graduat self report confid common task core skill compet procedur prior start fy measur increas prepared practic
D000086382;D010820;D013337
T047;T097;T067
36,323,476
associ non hdlc year prognosi patient spontan intracerebr haemorrhag prospect cohort studi hospit beij previous studi suggest invers associ lipoprotein cholesterol bleed risk limit data avail predict valu lipoprotein intracerebr haemorrhag ich recent research seri show higher non high densiti lipoprotein cholesterol non hdlc independ predictor favour month outcom ich patient thus aim investig associ non hdlc level year function outcom ich
D019161
T121;T109
36,323,475
risk factor workplac bulli sever psycholog distress suicid ideat covid pandem among general work popul japan larg scale cross section studi investig risk factor workplac bulli mental health outcom among worker covid pandem
D000086382;D000073397;D058445;D000079225
T067;T033;T054;T047;T048
36,323,474
usabl commerci activ monitor perceiv older adult research cross section evalu communiti live individu use commerci activ monitor may advanc research older adult howev usabl older popul suffici establish studi aim evalu usabl three wrist worn monitor older adult addit report usabl includ data manag research
D000072936;D014953
T029;T073
36,323,473
longitudin age studi amsterdam covid exposur index cross section analysi impact pandem daili function older adult aim studi develop index measur older adult exposur covid pandem studi associ various domain function
D058873;D000086382
T047;T067
36,323,472
valid icd code advers drug event hospitalis older adult protocol cross section studi advers drug event ade among hospitalis older adult common yet often prevent effort recognis ade use pharmacist review electron health record adapt mix result health system develop implement geriatr prescrib context design offer age friend dose frequenc default hospitalis patient year older impact context ade remain unknown measur impact team creat list ade relat intern classif diseas icd code specif common use medic institut protocol paper present process design screen tool ade valid tool manual chart review measur impact context ade
D038801;D064420
T170;T037;T046
36,323,471
effect ehealth intervent target improv medic adher among older adult mild cognit impair protocol systemat review meta analysi medic adher vital compon success healthcar yet poor adher exist especi older adult mild cognit impair therefor studi seek conduct systemat review ehealth base intervent aim improv medic adher among older adult mild cognit impair
D060825;D055118;D017216
T055;T033;T081;T058;T048