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biomedical-topic-categorization-validation

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36,323,470
oblig getaway qualit inquiri medic profession covid among medic student new physician taiwan hospit covid outbreak medic educ main concern prepar new physician medic student meet oblig healthcar provid novel circumst studi aim explor traine perceiv commit physician threat pandem
D013337;D000086382;D010820
T047;T067;T097
36,323,469
life covid road intens care back live prospect cohort studi aim studi evalu recoveri particip post covid patient first year intens care unit icu discharg secondari aim identifi earli determin associ recoveri particip
D000086382
T047;T067
36,323,468
trend preval incid regist dementia trend multimorbid among patient dementia general practic flander belgium registri base retrospect longitudin cohort studi age popul seem plausibl preval dementia multimorbid increas follow decad aim studi examin trend preval incid regist dementia trend multimorbid patient dementia general practic flander
D058006;D003704
T091;T048
36,323,467
cohort studi protocol brazilian collabor research network covid strengthen global data covid pandem hospit low incom countri face tripl challeng first larg number patient requir hospitalis infect sever symptom second lack systemat broad test polici earli identif case third weak integr inform system led need search avail inform hospit inform system accord also import state relev aspect covid natur histori yet fulli clarifi aim research protocol present strategi brazilian network hospit perform systematis data collect covid platform
D000086382
T047;T067
36,323,466
adher stay home order awar implement difficulti offici order quarantin measur context covid pandem cologn retrospect cohort studi estim awar implement difficulti behaviour recommend correl offici order domest isol quarantin covid pandem
D011790;D000086382
T061;T047;T067
36,323,465
industri strategi market opioid children women usa content analysi intern industri document releas state oklahoma v purdu pharma lp et al identifi advertis strategi use market opioid women children
D000701;D019460
T121;T092;T131;T109
36,323,464
cross section observ studi protocol miss microb infant born caesarean section mimic antenat antibiot mode deliveri intestin microbiom earli life play major role infant health develop factor like antibiot exposur breastformula feed mode deliveri known affect microbiom increas occurr caesarean section c section deliveri antibiot exposur warrant insight potenti miss microb infant studi object studi effect matern antibiot administr pregnanc andor c section mode deliveri develop infant intestin microbiom age year
D002585;D000069196
T061;T007;T079;T001
36,323,463
preval alzheim diseas rural urban area cuba factor influenc occurr epidemiolog cross section protocol accord world alzheim report around million peopl suffer dementia worldwid observ analysi reveal exist particular factor associ onset progress alzheim diseas ad intern homogen principl earli detect evalu memori impair possibl ad work aim determin preval possibl ad elder resid urban rural region cuba identifi main factor could signific influenc occurr
D000544
T047;T048
36,323,462
hyperbar oxygen treatment long covid syndrom hot loco protocol randomis placebo control doubl blind phase ii clinic trial long covid symptom persist week initi sar cov infect substanti problem individu societi surg pandem common symptom fatigu postexert malais cognit dysfunct current effect treatment under mechan unknown although sever hypothes exist chronic inflamm common denomin prospect studi hyperbar oxygen therapi hbot suggest effect treatment similar syndrom chronic fatigu syndrom fibromyalgia case seri suggest posit effect hbot long covid randomis placebo control clinic trial explor hbot potenti treatment long covid primari object evalu hbot improv health relat qualiti life hrqol patient long covid compar placebosham main secondari object evalu whether hbot improv endotheli function object physic perform short term hrqol
D000086382;D006931
T061;T047;T067
36,323,461
associ infect function somat disord cross section popul base cohort studi suggest infect trigger function somat disord fsd howev current evid limit inconsist find smaller studi conduct clinic set within select popul short follow time aim test hypothesi former infect associ fsd use data nationwid registri larg popul base cohort studi danish studi function disord studi
D043183;D059350
T184;T047
36,323,460
respiratori syncyti virus host genet suscept factor associ diseas sever cohort pediatr patient respiratori syncyti virus rsv infect lead caus hospit young children assess epidemiolog sever clinic characterist molecular profil genet factor rsv infect compar acut respiratori ill ari caus respiratori virus
D018113;D018357;D012141
T005;T047
36,323,455
shift paradigm biomed decolonis method inuit public health research canada scope review nation inuit strategi research focus advanc inuit govern research increas ownership data build capac respond call inuit self determin research academ research consid cultur safeti research way promot inuit led method
D011634;D004930
T098;T091
36,323,453
intestin pseudo obstruct caus giardia lamblia infect woman present malais nausea reduc appetit abdomin distent loos stool weight loss symptom start month earlier worsen last week ct enterographi show hypoton dilat small bowel loop absenc mechan obstruct endoscop examin includ capsul endoscopi reveal obstruct lesion delay small bowel transit time capsul duoden histolog reveal marsh villous atrophi secondari caus intestin pseudo obstruct villous atrophi investig giardia lamblia trophozoit found stool duoden biopsi patient symptom quick resolv metronidazol treatment complet normalis duoden histolog
D005873;D016829;D007418
T047;T204
36,323,452
humor hypercalcaemia malign associ gigant cutan squamous cell carcinoma humor hypercalcaemia malign rare associ cutan squamous cell carcinoma scc case report medic literatur present interest case gigant cutan scc associ sever hypercalcaemiaa man mid present rapid enlarg fungat mass scalp month laboratori studi log sever hypercalcaemia low intact parathyroid hormon elev parathyroid hormon relat peptid normal dihydroxi vitamin skin biopsi reveal moder differenti invas scc workup negat distant skelet metastas sever hypercalcaemia manag intraven fluid bisphosphon calcitonin multidisciplinari approach made patient receiv radiotherapi underw success surgic resect present case aim rais physician awar associ cutan scc hypercalcaemia sever hypercalcaemia detect earli prompt manag could fatal
D006934;D002294;D012878
T047;T191
36,323,451
granulomatosi polyangi adolesc male chronic cough pulmonari nodul granulomatosi polyangi gpa small medium vessel vascul uncommon paediatr howev chronic cough often initi symptom common complaint median age diagnosi year nevertheless import condit paediatrician consid otherwis go undiagnos long period time case report discuss paediatr patient gpa present non specif respiratori symptom sever month found pulmonari nodul chest imag broader differenti diagnosi consid review common present gpa classif criteria manag ultim assist provid identifi manag gpa case
D014890;D055613
T033;T047
36,323,450
pellagra differenti diagnosi confus patient acut medic unit man admit via acut medic take present increas confus featur alcohol withdraw sever month histori worsen prurit rash surround neck arm leg addit new profus diarrhoea view background known chronic alcohol coexist symptom rash confus diarrhoea pellagra diagnos via multidisciplinari approach oral nicotinamid supplement commenc symptom respond rapid bias challeng reach unifi diagnosi context multisystem condit exemplifi case report
D010383;D000437;D013375;D005076
T184;T047;T048
36,323,448
reconstruct chronic malunit galeazzi fractur distal radial ulnar joint instabl simpl modifi techniqu male present chronic malunit comminut galeazzi fractur disloc includ angular malunion radial shorten cm ulnar plus varianc distal radioulnar joint druj instabl secondari chronic disloc mechan rotat block modifi singl stage radius correct osteotomi bone graft techniqu overcorrect radius length employ restor normal druj motion stabil engag secondari druj stabilis without triangular fibrocartilag complex repair druj stabil restor via radius lengthen engag druj secondari stabilis bypass need complex ligament reconstruct patient return full activ recommend simpl yet effect approach treat chronic malunit galeazzi fractur druj instabl
D007593;D011885
T033;T037
36,323,447
endovascular salvag tubercular aortiti present descend thorac aortic pseudoaneurysm associ vertebr tuberculosi gentleman late present histori even rise temperatur generalis malais week durat associ upper back pain tingl numb lower limb unexplain episod hypotens hemoptysi propel comput tomographi ct examin chest suggest pseudoaneurysm posterior wall descend thorac aorta vicin pott spine prevertebr paravertebr abscess refer vascular surgeonstubercular involv vasculatur rare diseas aortic involv even rarer less case vertebr tuberculosi tubercular thorac aortic aneurysm report medic literatur diseas carri coloss mortal morbidityaft multidisciplinari teamwork thorac endovascular aortic repair done exclus aneurysm segment simultan antitubercular broad spectrum antibiot chemotherapi patient recuper well
D017541;D001025;D017545;D014381;D014376;D057510;D019917
T061;T047;T046
36,323,443
pan canadian colorect cancer surgeri data opportun reflect improv variat data provid opportun health care provid assess patient care improv pan canadian colorect cancer data show although long term surviv similar among provinc differ exist import aspect care length stay minim invas approach readmiss short term mortal examin variat among stakehold involv colorect cancer allow opportun reflect optim care
D013505;D015179
T061;T191
36,323,436
april antibodi fragment base car cell myeloma induc bcma downmodul trogocytosi intern chimer antigen receptor car cell therapi target b cell matur antigen bcma multipl myeloma mm produc fast long last respons reason treatment failur poor understood car simultan target two antigen may repres altern design character novel prolifer induc ligand april base dual antigen target car investig mechan resist car cell three differ bcma bind moieti april singl chain variabl fragment heavi chain
D000076962;D009101;D057127
T129;T191;T116;T192
36,323,435
virtual clinic trial anti pd anti ctla immunotherapi advanc hepatocellular carcinoma use quantit system pharmacolog model hepatocellular carcinoma hcc common form primari liver cancer third lead caus cancer relat death worldwid patient hcc diagnos advanc stage median surviv patient advanc hcc treat modern system therapi less year leav advanc stage patient limit treatment option immun checkpoint inhibitor ici target program cell death protein pd ligand wide use treatment hcc associ durabl respons subset patient ici target cytotox lymphocyt associ protein ctla also clinic activ hcc combin therapi nivolumab anti pd ipilimumab anti ctla first treatment option hcc approv food drug administr target one immun checkpoint
D006528;D008113
T191
36,323,434
intraven administr viral vector express prostat cancer antigen enhanc magnitud function cd cell respons use immunotherapeut vaccin prostat cancer promis approach like requir induct function cytotox cell experiment approach describ use well studi adenovirus poxvirus heterolog prime boost regimen vector encod combin prostat cancer antigen booster dose deliv either intraven intramuscular im rout prime boost regimen investig antigen specif cd cell induct
D017430;D011471
T129;T191;T126;T116
36,323,433
identif natur product diiodotyrosin apobecb inhibitor prevent somat mutat accumul cancer progress develop cancer larg depend accumul somat mutat indic potenti develop cancer chemoprevent agent target mutat driver howev ideal cancer chemoprevent agent effect inhibit mutat driver identifi yet
D001688;D003092;D003110;D004938;D000077277
T123;T047;T121;T191
36,323,432
gut microbiom deplet antibiot regimen toler mous strain learn bitter experi gut microbiom critic success checkpoint inhibitor cancer therapi question remain unansw progress slow argu lack advanc due unappreci biolog detail show antibiot cocktail use semin public use cbl mous strain bitter toler common mous strain ie balbc dba write alert reader import biolog limit must consid plan cancer experi investig gut microbiota prevent unnecessari dehydr experiment anim save colleagu valuabl experiment time resourc
D000069196;D009369
T007;T191;T001
36,323,431
bispecif antibodi target cd tumor associ antigen promot cross prime cell result antitumor respons superior monospecif antibodi indic poor cell infiltr defici cell prime associ unrespons establish immunotherapi repres unmet medic need oncolog cd target therapi design enhanc antigen present generat new tumor specif cell activ tumor infiltr myeloid cell remodel tumor microenviron repres promis opportun meet need studi present first vivo data support role tumor associ antigen taa mediat uptak cross present tumor antigen enhanc tumor specif cell prime use cdtaa bispecif antibodi concept name neo x prime
D045142;D018033
T129;T121;T116;T043
36,323,430
immun base biomark accur predict respons imiquimod immunotherapi cervic high grade squamous intraepitheli lesion complet respons rate cervic high grade squamous intraepitheli lesion chsil patient imiquimod immunotherapi approxim consequ mani patient expos unnecessari advers effect imiquimod hand convent surgic larg loop excis therapi associ increas risk prematur birth subsequ pregnanc depth analysi chsil immun microenviron perform order identifi develop predict biomark respons imiquimod maxim therapi efficaci avoid advers effect patient unlik respond
D002278;D000081483;D002294
T033;T191
36,323,422
prognost factor mortal intens care unit hospit admiss due sar cov systemat review meta analysi cohort studi europ mortal coronavirus diseas covid strong age depend aim identifi popul subgroup elev risk advers outcom covid use age gender adjust data european cohort studi aim identifi popul could potenti benefit booster vaccin
D000086382;D006760;D007362
T073;T067;T093;T047;T058
36,323,421
clinic signific neutrophil lymphocyt ratio platelet lymphocyt ratio acut exacerb copd present futur acut exacerb chronic obstruct pulmonari diseas aecopd lead caus hospitalis death copd patient addit identif better strategi prevent aecopd intens focus discov novel marker diseas sever enhanc risk stratif hospit admiss target institut aggress versus support treatment quest biomark increas bodi evid suggest specif index deriv routin complet blood count ie neutrophil lymphocyt ratio nlr platelet lymphocyt ratio plr signific predict advers outcom aecopd narrat review discuss current evid regard associ nlr plr admiss sever clinic end point need invas ventil noninvas mechan ventil failur admiss intens care unit pulmonari hypertens length hospitalis mortal aecopd futur research direct potenti clinic applic haematolog index patient group also discuss
D009504;D029424
T047;T025
36,323,418
preval risk factor treatment post covid breathless systemat review meta analysi persist breathless day acut covid infect identifi high debilit post covid symptom howev preval risk factor mechan treatment post covid breathless remain poor understood systemat search pubm embas relev studi publish januari novemb prospero registr number crd includ elig paper random effect meta analysi patient covid report paper found overal preval post covid breathless ci measur presenceabs symptom ci use medic research council mrc modifi mrc dyspnoea scale pool preval decreas signific month month post infect post covid breathless common severecrit acut infect hospitalis femal less like report patient asia europ north america multipl pathophysiolog mechan propos includ decondit restrictiveobstruct airflow limit system inflamm impair mental health bodi evid remain inconclus seven cohort studi one randomis control trial suggest rehabilit exercis may reduc post covid breathless urgent need mechanist research develop intervent prevent treatment post covid breathless
D000086382
T047;T067
36,323,417
risk serious covid outcom among adult children moder sever asthma systemat review meta analysi joint committe vaccin immunis unit kingdom request evid synthesi investig relationship asthma coronavirus diseas covid outcom
D018927;D000086382;D001249
T121;T047;T067
36,323,407
transmiss dynam monkeypox unit kingdom contact trace studi analys transmiss dynam monkeypox outbreak uk declar public health emerg intern concern juli
D045908;D000086382;D000072339
T047;T098;T067
36,323,335
improv user experi discount site specif user test poor electron health record ehr usabl associ patient safeti concern user dissatisfact provid burnout ehr certif requir vendor perform user test howev requir site specif implement health care organ custom ehr implement potenti introduc usabl problem site specif usabl evalu may help identifi concern discount usabl method afford health system mean even without dedic usabl specialist report character site specif discount user test program launch academ medic center describ lesson learn highlight three ehr featur detail demonstr impact test implement decis user
D057286;D000066506
T170;T073
36,323,312
epigenet state il polar macrophag enabl inflammatori cistrom expans extend synergist respons tlr ligand prior exposur microenvironment signal could fundament chang respons macrophag subsequ stimuli believ helper th cell type cytokin interleukin il toll like receptor tlr ligand activ transcript program mutual antagon remark converg identifi contrast show il polar macrophag establish hyperinflammatori gene express program upon lipopolysaccharid lps exposur phenomenon term extend synergi support il direct epigenom remodel lps activ nf b p cistrom expans increas enhanc activ egr transcript factor contribut extend synergi macrophag subtyp specif manner consequ previous altern polar macrophag produc increas amount immun modulatori factor vitro vivo murin th cell type airway inflamm model upon lps exposur find establish il induc epigenet reprogram respons develop inflammatori hyperrespons tlr activ contribut lung patholog
D015847;D008070
T129;T121;T116;T109
36,323,311
mening macrophag protect viral neuroinfect surfac central nervous system cns protect mening contain dens network mening macrophag mms examin role tissu resid mm viral infect mhc ii mm abund neonat wherea mhc ii mm appear time barrier macrophag differenti respond vivo peripher challeng lps sar cov lymphocyt choriomening virus lcmv peripher lcmv infect asymptomat led transient infect activ mening mice lack macrophag conserv brain microglia mice bear macrophag specif delet stat ifnar exhibit extens viral spread cns transcrani pharmacolog deplet strategi target mm local result sever area mening becom infect fatal mening low number mhc ii mm seen upon lps challeng neonat corel higher viral load upon infect thus mms protect viral infect may present target therapeut manipul
D000086382;D008216
T047;T067
36,323,303
refractori headach medic overus headach moh new daili persist headach ndph persist refractori headach attribut sever acut respiratori syndrom coronavirus sar cov infect repres signific burden term disabl qualiti life challeng term definit pathophysiolog treatment regard moh prevent without withdraw inferior prevent withdraw prevent medic like topiram onabotulinumtoxina calcitonin gene relat peptid cgrp monoclon antibodi improv chronic migrain moh regardless withdraw differenti diagnosi ndph broad care examin guidelin treatment ndph option includ short cours steroid nerv block topiram nortriptylin gabapentin cgrp monoclon antibodi onabotulinumtoxina persist headach month sar cov infect predictor poor prognosi
D019274;D000086382;D051271;D020773
T129;T121;T116;T067;T109;T131;T047
36,323,302
acut treatment headach focus migrain acut treatment migrain cluster headach necessari abort attack reliev pain associ symptom restor individu abil function acut headach treatment consist varieti medic nonmed option articl discuss approach acut treatment migrain cluster headach summar level evid support acut medic class accord recent systemat review meta analys well guidelin recommend american headach societi american academi neurolog european feder neurolog societi
D003027;D008881;D009462
T047;T091
36,323,301
headach pediatr popul focus migrain pediatr headach common condit signific impact qualiti life abil function academ social extracurricular activ pediatr patient seen primari care neurolog clinic headach primari headach disord diagnosi larg base clinic histori imag rare need absenc red flag featur care diagnosi import guid appropri treatment treatment focus biopsychosoci model integr lifestyl pharmacolog nonpharmacolog treatment modal therapi approv pediatr popul treatment often use label base evid extrapol adult studi outcom vari time general favor headach disord diagnos prompt manag multidisciplinari set
D008881;D020773
T047
36,323,300
recent advanc updat trigemin autonom cephalalgia trigemin autonom cephalalgia tac discret primari headach disord character sever unilater head pain typic trigemin distribut ipsilater cranial autonom symptom condit within group hemicrania continua cluster headach paroxysm hemicrania short last unilater neuralgiform headach conjunctiv inject tear short last unilater neuralgiform headach autonom symptom sever advanc made understand pathogenesi evolv treatment option tac review outlin advanc updat tac
D051303;D003027;D009437
T184;T047
36,323,299
anatomi physiolog headach headach disord produc recurr incapacit pain migrain cluster headach notabl abil produc signific disabl anatomi physiolog headach disord fundament evolv treatment approach research prioriti key concept headach mechan includ activ sensit trigeminovascular brainstem thalam hypothalam neuron modul cortic brain region activ descend pain circuit review examin relev anatomi trigemin brainstem subcort cortic brain region concept relat pathophysiolog migrain cluster headach disord
D008881;D003027;D020773
T047
36,323,298
migrain posttraumat headach similar differ brain network connect posttraumat headach pth common symptom follow mild traumat brain injuri mtbi also known concuss migrain pth similar phenotyp migrain like phenotyp common pth similar headach type intrigu challeng better understand pathophysiolog common involv migrain pth due mtbi review pth rest state function connect literatur compar migrain assess overlap differ brain network function headach type migrain pth due mtbi overlap diseas specif widespread alter static dynam function network involv pain process well dysfunct network connect frontal region area pain modul pain inhibit although pth function network literatur still limit evid dysregul top pain control system under migrain pth howev diseas specif differ function circuitri observ well may reflect uniqu differ brain architectur pathophysiolog under headach disord
D051298;D008881;D001924
T047;T046;T037
36,323,292
unilater mandibular fractur hors treatment fixateur extern complic implant remov procedur remov implant fragment first part case report describ surgic treatment unilater mandibular fractur stand hors use fixateur type time implant remov fractur complet heal howev implant remov implant failur implant occur fragment remain bone second part report focus develop special surgic instrument design remov implant fragment furthermor surgic method allow entir extirp fragment within second surgeri describedaccord author knowledg first case report show use present surgic techniqu treatment mandibular fractur stand hors addit report also provid approach remov implant fragment depth bone may occur case implant breakag potenti complic describ surgeri
D020878;D008337
T061;T037
36,323,291
cystic endometri hyperplasia uterin adenocarcinoma two miniatur pig due increas popular minipig pet frequenc present veterinarian increas well addit routin measur claw trim vaccin antiparasit treatment diagnost therapi diseas minipig also common activ veterinari practic recent year notic patholog chang femal genit tract uncastr minipig also case report avail intern literatur regard follow case report describ diagnost procedur ovariohysterectomi year old femal minipig detail case uterin adenocarcinoma uterin carcinoma respect combin cystic endometri hyperplasia ceh endometrium diagnos
D004714;D014594;D000230;D013553
T047;T191
36,323,290
swine inflamm necrosi syndrom sin review inflamm partial loss tail occur high frequenc pig must combat anim welfar improv context consider tail bite sole explan fail go far enough inflamm necrosi tail occur regular even without intervent pig evid alter alreadi time birth cluster synchron occurr differ part bodi tail ear teat claw amongst other well pathohistolog evid blood vessel associ chang advoc primarili endogen caus bear syndrom charact even symptomatolog interact environment factor alter may observ suckl wean piglet well fatten environment improv may lead signific reduc symptomatolog time genet effect boar sow demonstr review articl highlight facet syndrom known date provid insight key point pathogenesi awar new clinic syndrom must distinguish tail bite afford contribut combat entiti thus increas anim welfar swine
D001733;D013553
T047;T037
36,323,289
opinion among veterinarian equin lyme diseas result questionnair studi record equin veterinarian opinion equin lyme diseas
D018634;D008193;D006734
T047;T097
36,323,288
comparison effici inhal inject anaesthesia castrat male suckl piglet differ organ farm germani inject inhal anesthesia addit analges drug interim solut surgic castrat general anesthesia due ban non anesthet castrat male suckl piglet day age howev effici anesthet procedur submit controversi discuss studi address question examin one procedur comparison piglet castrat without anesthesia uncastr control comparison anesthesia method especi condit organ work farm almost complet lack aim present studi therefor compar efficaci inject inhal anesthesia practic condit organ farm well examin effect metamizol administ addit meloxicam
D058871;D000758
T061;T080;T057
36,323,287
survey among keeper endang sheep goat breed influenc wolv anim husbandri germani wolf popul steadili becom widespread conflict livestock owner increas context wolv impact graze livestock particular interest studi aim investig wolv influenc husbandri endang sheep goat breed thus livestock owner interview type measur taken protect herd wolf predat
D019596
T015
36,323,281
bleed issu women oral anticoagul premenopaus women treatment direct oral anticoagul doac associ increas risk heavi menstrual bleed hmb compar vitamin k antagonist find come retrospect prospect singl center studi post hoc analysi regulatori studi hmb predefin safeti outcom public lack inform use differ contracept method influenc hmb anoth limit various definit hmb make comparison studi regard incid hmb difficulttherefor prospect studi urgent need investig sever durat unaffect menstrual bleed oral anticoagul independ oral contracept intrauterin devic ongo multicent german registri aim compar incid unaffect hmb consecut women reproduct age year treat differ doac venous thromboembolismwhen hmb occur oral anticoagul manag includ interrupt dose reduct anticoagul danger recurr venous thrombosi switch anoth oral anticoagul addit use antifibrinolyt agent tranexam acid potenti risk thrombosi concomit use either oral hormon contracept therapi hormon releas intrauterin system also reduc hmb
D008595;D000933
T121;T046
36,323,280
von willebrand diseas specif aspect women von willebrand diseas vwd common inherit bleed disord result defici dysfunct von willebrand factor vwf major symptom patient affect vwd includ mucocutan gastrointestin bleed easi bruis prolong provok bleed due injuri surgeri although women men equal like affect vwd women continu disproportion affect bleed challeng women vwd suffer sex specif symptom menorrhagia higher risk reproduct problem recurr miscarriag furthermor pregnant women vwd like higher risk suffer primari secondari peripart hemorrhag anemia need transfus despit affect gynecolog obstetr bleed women face multipl barrier obtain accur diagnosi constitut problem need address earli appropri medic care ensur sever effect treatment option women vwd signific improv qualiti life includ desmopressin vwf concentr hormon therapi antifibrinolyt therapi pregnanc monitor vwf activ level essenti peripart manag depend type vwd measur level vwf level activ prior deliveri
D014842;D008595
T047;T046
36,323,279
manag antithrombin defici pregnanc antithrombin defici high risk thrombophilia rare condit risk venous thromboembol vte increas defici women pregnanc postpartum period especi high women prior histori vte thorough assess vte risk recommend pregnant defici women compris degre type defici genet mutat person famili histori addit preexist pregnanc specif risk factor due lack adequ studi data limit guidanc manag defici pregnanc includ need prophylact anticoagul appropri dose low molecular weight heparin lmwh role substitut lmwh medic choic pharmacolog prophylaxi treatment vte pregnanc patient histori vte receiv full dose lmwh pregnanc postpartum period concentr treatment option anticoagul withheld potenti high risk event childbirth bleed surgeri case acut vte despit use therapeut dose anticoagul women defici counsel special center coagul disord vascular medicin close cooper obstetrician anesthesiologist warrant deliveri peripartum period
D054556;D020152
T047
36,323,278
venous thromboembol women cancer addit focus breast gynecolog cancer cancer associ venous thromboembol vte common women cancer mani clinic practic guidelin provid guidanc prevent treatment howev specif recommend women unfortun proport women breast gynecolog cancer high among patient cancer associ vte thromboembol often herald cancer progress poor prognosi besid adequ anticoagul manag also prompt reassess necessari chang cancer treatment recent new class direct act oral anticoagul doac start replac low molecular weight heparin standard thromboprophylaxi therapi cancer patient effect also carri relev risk bleed therefor despit eas use everi tumor patient qualifi doac especi true gynecolog tumor patient prescript must weigh individu review address specif aspect vte prophylaxi manag women cancer everi physician treat breast gynecolog cancer familiar prophylaxi diagnosi therapi cancer associ vte time patient inform physician symptom look contact symptom occur even outsid offic hour weekend
D054556;D009369
T047;T191
36,323,277
transgend medicin risk venous thromboembol gender dysphoria refer psycholog distress result incongru gender ident sex assign birth administr sex hormon often use first step develop maintain physic characterist consist gender ident gender affirm hormon treatment consid benefici qualiti life reduct depress howev estrogen androgen lower hormon therapi use transwomen particular associ increas risk venous thromboembol review introduc clinic case provid overview current avail medic therapi transgend medicin put associ increas risk venous thromboembol perspect
D063106;D054556
T047;T098
36,323,276
venous thromboembol issu women lifetim risk venous thromboembol vte slight higher women men sever issu relat vte uniqu women combin hormon contracept pregnanc increas risk vte women childbear age wherea hormon replac therapi increas vte risk postmenopaus women hereditari thrombophilia risk factor older age obes smoke contribut risk increas women diagnos acut hormon relat vte treat oral anticoagul adequ contracept mandatori avoid unwant pregnanc accord current knowledg hormon contracept may continu anticoagul therapi must switch estrogen free contracept method least week termin anticoagul vte also major caus matern morbid mortal pregnanc postpartum period current assist reproduct technolog vitro fertil wide use treat coupl affect infertil complic fertil treatment compris vte case especi women ovarian hyperstimul syndrom review intend focus vte issu women summar current evid guidelin recommend
D054556;D019851
T047
36,323,273
imag find minipig congenit portosystem shunt month old male minipig present clinic histori seizur activ one year minipig smallest among litterm refer due elev blood ammonia level suspect portosystem shunt pss ultrasound ct angiographi consist congenit extrahepat pss author knowledg first descript congenit extrahepat pss diagnos ultrasound contrast enhanc comput tomographi minipig pig partial shunt closur perform intervent stent applic
D019168
T061
36,323,272
prevent canin parvovirosi part vaccin failur although vaccin canin parvovirus cpv use worldwid cpv infect still occur relat common main young dog review articl focus differ caus vaccin failur various factor affect dog environ respons subset dog fail develop antibodi non respond produc low antibodi titer low respond follow vaccin cpv genet reason addit vaccin efficaci affect intrins factor e g weight age reproduct nutrit status diseas andor extrins factor e g stress physic strain medic addit caus affect individu dog vaccin failur also caus reduc immun properti vaccin varieti differ factor e g manufactur storag applic respons effect
D014765;D004283;D017993;D010322
T129;T047;T121;T005
36,323,271
limb fractur pet rabbit oryctolagus cuniculus f domestica case seri orthoped long term effect fractur patient limb fractur account larg proport orthoped diseas pet rabbit common reason present fractur etiolog characterist vari consider comparison trauma extrem cat dog reason conserv surgic treatment option need adapt knowledg long term effect limb fractur therapi pet rabbit describ scientif
D005121;D050723
T023;T037
36,323,270
influenc verordnung ber tierrztlich hausapotheken antimicrobi use dog cat bavaria aim studi collect data concern use antibiot ab dog cat veterinari practic clinic bavaria germani evalu whether chang use ab sinc amend verordnung ber tierrztlich hausapotheken thav german regul veterinari hous pharmaci march could document
D002371;D004283;D018634;D000890
T121;T047;T097
36,323,269
clinicopatholog characterist postop outcom prognost factor dog primari pulmonari carcinoma retrospect studi dog canin primari pulmonari carcinoma plc treat surgic goal studi increas veterinari databas concern clinic patholog find postsurg median surviv time mst prognost factor tumor type
D004283;D008175;D002277
T047;T191
36,323,265
hyper excit corticothalam pt neuron mpfc promot irrit mous model alzheim diseas neuropsychiatr symptom patient alzheim diseas ad present earli mild cognit impair mci stage howev remain unclear whether separ neuron popul encod distinct aspect neuropsychiatr symptom drive differ report pyramid tract pt neuron project thalamus pon medulla medial prefront cortex mpfc mous model ad show increas excit associ increas irrit aggress decreas kv corticothalam pt neuron contribut hyper excit tight associ aggress behavior overexpress kv prevent abnorm excit corticothalam pt neuron mpfc also rescu aggress behavior xtg model mice studi provid causal evid contribut corticothalam pt neuron irrit xtg model ad reveal circuit mechan use pt neuron regul neuropsychiatr symptom ad
D000544
T047;T048
36,323,264
arida loss potenti pancreat cell regener activ egf signal dynam regul cell abund poor understood sinc chromatin remodel play critic role liver regener mechan could general import regener tissu show arida mammalian swisnf complex subunit critic regul cell regener arida high express quiescent cell physiolog suppress cell prolifer pregnanc pancrea resect whole bodi arida knockout mice protect streptozotocin induc diabet cell type tempor specif genet dissect show cell specif arida delet potenti cell regener multipl context transcriptom epigenom profil mutant islet reveal increas neuregulin erbb nra signal chemic inhibit erbb nra block increas regener associ arida loss mammalian swisnf mswisnf complex activ barrier cell regener physiolog diseas state
D004815;D009687
T125;T121;T123;T116
36,323,263
neural circuit dorsal ca dorsomedi hypothalamus mediat balanc risk explor defens appropri balanc explor defens behavior essenti surviv reproduct prey anim riski environ howev neural circuit mechan allow balanc remain poor understood use semi naturalist predat threat test ptt observ quantifi defens explor balanc especi risk explor behavior mice ptt activ putat dorsal ca glutamaterg neuron dca glu suppress predatori threat risk explor wherea neuron activ contextu explor moreov optogenet excit neuron induc signific increas risk explor circuit compris dorsal ca dorsal later septal dorsomedi hypothalam dca glu dls gaba dmh area may involv moreov activ dca glu dls gaba dmh circuit promot switch defens risk explor suppress threat induc increas arous
D004111
T121;T109
36,323,262
nuclear stabil p requir function nucleolar surveil pathway nucleolar surveil pathway monitor nucleolar integr respond nucleolar stress mediat bind ribosom protein mdm result p accumul inappropri pathway activ implic pathogenesi ribosomopathi drug select activ pathway trial cancer despit molecular mechan regul process poor understood use genom wide loss function screen demonstr ribosom biogenesi axi potent class gene whose disrupt stabil p mechanist identifi gene critic regul pathway includ heatr select disabl nucleolar surveil pathway demonstr essenti abil nuclear act stress includ dna damag induc p accumul data support paradigm wherebi nucleolar surveil pathway central integr stress regul nuclear p abund ensur ribosom biogenesi hardwir cellular prolif capac
D016159;D051736
T123;T116
36,323,261
integr singl cell transcriptom chromatin access earli gonad develop among goat pig macaqu human earli gonad mammal contain primordi germ cell pgcs somat cell precursor essenti sex determin gametogenesi although extens document mice develop earli gonad non rodent remain delin molecular differ mous human gonad cell report warrant studi key marker regulatori featur conserv diverg non rodent speci human integr singl cell transcriptom chromatin access analysi identifi regulatori signatur pgcs somat cell earli gonad goat pig macaqu human identifi evolutionarili conserv speci specif event includ gene express signal pathway cell cell interact also uncov potenti cis regulatori element key transcript factor pgcs somat cell dataset provid import resourc better understand evolutionari program pgcs gonad somat cell develop mammal
D002843;D059467
T081;T116;T086
36,323,260
cd regul transcript normal b cell cd receptor cytokin macrophag migrat inhibitori factor mif mif bind cd induc signal cascad result releas cytosol intracellular domain cd icd serv transcript regul chronic lymphocyt leukemia cll cell current studi investig transcript regulatori function cd icd normal b cell show follow activ cd icd form complex cytosol transcript factor like pax bind chromatin signific higher number site compar bind cll cell express major portion bound gene shut malign cell cd icd pax complex bind promot area tumor suppressor gene dmtf downregul express inhibit transcript find help identifi novel therapeut pathway regul oncogen transform target futur treatment
D015451;D001402
T191;T025
36,323,259
identif character innat lymphoid cell generat pluripot stem cell innat lymphoid cell ilc play import role regul tissu homeostasi innat immun respons generat ilc engraft pluripot stem cell psc deriv hematopoiet progenitor ihpc yet report document ilc exist rag ilrg recipi engraft psc deriv ihpc guid runx hoxa express upon transplant ihpc immedi give rise ilc relat progenitor contain common helper ilc progenitor bone marrow follow restrict popul name ilc progenitor abl differenti matur ilc primari secondari immunodefici recipi psc deriv ilc exhibit multipl tissu distribut normal immunolog function singl cell transcriptom illustr development trajectori psc deriv ilc vivo consist natur ilc studi provid insight generat ilc anim transplant psc deriv ihpc cell sourc
D007113;D039904
T032;T025
36,323,258
mobil phospholipid tumor plasma membran implic phosphatidylserin extern blockad cancer immunotherapi healthi tumor cell phosphatidylserin ps predomin local inner plasma membran leaflet apoptosi ps reloc outer leaflet herein establish ps tumor model tumor cell lack ps flippas compon cdca constant expos ps aliv ps tumor develop bigger wild type wt tumor featur polar tumor associ macrophag tam fewer tumor antigen specif cell ps receptor tim respons ps recognit employ opposit tumor model ps tumor cell lack ps scramblas xkr unabl expos ps otherwis normal apoptosi find accumul apoptot tumor cell produc releas cyclic gamp cgamp immun cell activ sting pathway lead tam polar suppress interleukin il secret natur killer nk cell cytotox silenc xkr vivo either short hairpin rna shrna small interf rna sirna achiev ps extern blockad provid robust therapeut anti tumor effici
D010718;D009369
T191;T109
36,323,257
disrupt mtorc rescu neuron overgrowth synaps function dysregul pten loss phosphatas tensin homolog delet chromosom pten negat regul aktmtor signal pathway mutat pten found patient autism epilepsi macrocephali mous model pten loss result neuron hypertrophi hyperexcit seizur asd like behavior under molecular mechan phenotyp well delin determin pten loss driven aberr neuron form function orchestr downstream mtor complex mtorc rapamycin mediat inhibit mtorc prevent increas soma size migrat spine densiti dendrit overgrowth pten knockout dentat gyrus granul neuron genet knockout raptor disrupt mtorc complex format block pten loss mediat neuron hypertrophi electrophysiolog record reveal genet disrupt mtorc rescu pten loss mediat increas excitatori synapt transmiss identifi essenti role mtorc orchestr pten loss driven neuron hypertrophi synaps format
D009474;D013569
T025;T030
36,323,256
spatiotempor genet regul edit throughout human brain develop posttranscript rna modif adenosin inosin edit abund brain yet elucid function site remain challeng bridg gap investig spatiotempor genet regul edit site across prenat postnat stage human brain develop spatiotempor regul site identifi occur predomin utr intron well site recod amino acid protein code region precis chang edit level across develop hyper edit transcript also enrich age brain stabil rna secondari structur featur conserv murin non human primat model neurodevelop final thousand cis edit quantit trait loci edqtl identifi uniqu regulatori effect prenat postnat develop collect work offer resolv atlas link spatiotempor variat edit level genet regulatori effect throughout distinct stage brain matur
D017393;D007288
T045;T121;T114
36,323,255
melanocortin receptor activ sympathet preganglion neuron elev blood pressur via trpv melanocortin receptor mcrs express central nervous system essenti regul energi homeostasi mcr mutat common caus human monogen obes notabl patient obes carri mcr mutat protect obes induc hypertens mcr agonist elev blood pressur bp although increas sympathet tone mcrs suggest underli phenotyp detail mechan remain unclear investig mcrs regul sympathet preganglion neuron find mcrs activ neuron via protein kinas depend activ transient receptor potenti vanilloid trpv channel import demonstr inhibit trpv prevent mcr induc elev bp affect mcr induc anorexia show trpv respons mcr depend activ sympathet preganglion neuron high fat diet togeth result provid insight mcrs regul sympathet function
D044105;D009765
T047;T116;T192
36,323,254
cholinerg receptor wnt pathway control immun activ sens intestin dysfunct alter intestin physiolog caus pathogen colon result immun activ provid insight mechan under control immun activ chang intestin homeostasi conduct forward genet screen suppressor immun activ intestin distens caenorhabd elegan result indic c elegan acc member famili acetylcholin receptor requir immun activ defect defec motor program pathogen infect acc act postsynapt non cholinerg rim neuron regul sever immun gene wnt mediat host immun respons find uncov gut brain microbi axi use neural cholinerg signal wnt pathway control immun activ respons alter intestin homeostasi
D017173;D029742
T116;T204
36,323,253
acut deplet human core nucleoporin reveal direct role transcript control dispens genom organ nuclear pore complex npc compris nucleoporin nup hallmark eukaryot nup suggest import regul gene transcript genom organ howev evid support direct role remain limit cut run find core nup display broad also cell type specif associ activ promot enhanc human cell auxin mediat rapid deplet two nup demonstr nup nup direct specif control gene transcript nup direct activ gene high level rna polymeras ii load transcript elong facilit full brd recruit activ enhanc dcas base tether confirm direct causal role nup gene transcript activ unexpect situ hi c hkac hkme hichip result upon acut nup deplet show neglig changess genom organ rang ab compart topolog associ domain tad enhanc promot contact
D028861;D009687
T123;T116
36,323,252
tempor analysi suggest reciproc relationship chromatin structur transcript infer potenti causal relationship chromatin structur enhanc gene transcript map featur genom wide fashion across eight narrowli space time point macrophag activ enhanc gene connect loop exhibit stronger correl histon hk acetyl express explain genom distanc physic proxim alon loop enhanc promot pair chang acetyl distal enhanc preced chang gene express chang gene express exhibit direct bias differenti loop anchor gain loop associ increas express gene orient away center loop lost loop often accompani high level transcript within loop boundari result consist reciproc relationship loop facilit increas transcript connect promot distal enhanc wherea high level transcript imped loop format
D002843;D023281
T091;T116
36,323,251
er mitochondri contact protein miga regul autophagi atg uvrag mitochondri malfunct autophagi defect often concurr phenomena associ neurodegener show miga mitochondri outer membran protein regul endoplasm reticulum mitochondri contact site ermcss requir autophagi loss miga result accumul autophagi marker substrat wherea pip syx level reduc experi indic fusion autophagosom lysosom defect miga mutant miga bind atg uvrag concord miga overexpress result atg uvrag recruit mitochondria heighten pik activ induc miga requir uvrag wherea miga mediat stabil syx depend atg miga regul ermcss critic pip format essenti stabil syx summari identifi mitochondri protein regul autophagi recruit two altern compon pik complex present ermcss
D024101;D001343
T123;T116;T043
36,323,250
alloster potenti gaba receptor singl channel conduct netrin neuron excit induc inhibitori synapt homeostasi princip receptor mediat synapt tonic inhibit neuron brain type gamma aminobutyr acid receptor gaba r function import maintain balanc neuron excit inhibit report identif netrin endogen alloster modul gaba rs follow increas neuron excit netrin secret bind extracellular domain gaba r subunit therebi induc homeostat upscal gaba r mediat synapt efficaci current surpris homeostat plastic primarili mediat increas gaba r singl channel conduct studi reveal import role netrin endogen gaba r alloster modul maintain neuron excit inhibit balanc fundament process brain function dysfunct
D011963;D009474
T116;T025;T192
36,323,249
metabol regul p prevent r loop associ genom instabl gene environ interact perturb epigenom trigger network alter particip cancer pathogenesi integr epigenom transcriptom metabol analys function perturb show tumor suppressor p preserv genom integr empow adequ level univers methyl donor adenosylmethionin sam p defici cell perturb dna methyl promot derepress heterochromatin massiv loss histon h lysin methyl consequ upregul satellit rnas trigger r loop associ replic stress chromosom aberr p defici cell inadequ sam level under inabl respond perturb exogen reintroduct sam repress satellit element restor abil cope stress mechanist p transcript control gene involv one carbon metabol includ slca methionin uptak transport critic sam synthesi support clinic data find shed light role p mediat metabol prevent unschedul r loop associ genom instabl
D016159;D000080870
T123;T116;T114
36,323,248
multi omic profil reveal ataxia protein sacsin requir integrin traffick synapt organ autosom recess spastic ataxia charlevoix saguenay arsac childhood onset cerebellar ataxia caus mutat sac encod protein sacsin cellular arsac phenotyp includ mitochondri dysfunct intermedi filament disorgan progress death cerebellar purkinj neuron unclear loss sacsin caus deficit manifest cerebellar ataxia perform multi omic profil sacsin knockout ko cell identifi alter microtubul dynam misloc focal adhes fa protein includ multipl integrin deficit fa structur signal function rescu target pten negat regul fa signal arsac mice possess misloc itga purkinj neuron synapt disorgan deep cerebellar nucleus dcn sacsin interactom reveal sacsin regul interact cytoskelet synapt adhes protein find suggest disrupt traffick synapt adhes protein causal molecular deficit arsac
D002524
T033;T184;T047
36,323,247
rbef axi key regul molecular signatur instruct quiescent activ adult neural stem cell state long term mainten adult neurogen nich depend proper regul entri exit quiescenc neural stem cell nsc transit quiescenc activ complex process requir precis cell cycl control coordin transcript morpholog chang nsc fate transit coordin cell cycl machineri remain poor understood show rbef axi function link cell cycl machineri pivot regul nsc fate delet rb famili protein result activ nscs induc transcriptom transit toward activ delet target activ ef result intract quiescenc cessat neurogenesi show rbef axi mediat fate transit regul factor essenti nsc function includ rest ascl thus rbef axi import regul nsc fate coordin cell cycl control nsc activ quiescenc fate transit
D058953;D053687
T025
36,323,246
isol target high activ stochast dendrit cell subpopul improv immun respons dendrit cell dc activ via pathogen associ molecular pattern pamp critic antigen present develop adapt immun respons stochast distribut dc respons pamp signal especi initi stage immun activ poor understood studi isol uniqu dc subpopul via preferenti phagocytosi microparticl mps character subpopul first respond frs present result show cell isol studi via increas accumul micron size particl combin cell surfac marker show increas respons pamp facilit adapt immun respons provid initi paracrin signal select target vaccin modul antibodi cell respons vivo studi present insight tempor control distinct cell popul influenc downstream immun respons furthermor demonstr potenti improv vaccin design via fr target
D003713;D014612
T129;T121;T025;T116
36,323,236
mitochondri dna qualiti control femal germlin requir uniqu program mitophagi mitochondria dna mtdna suscept accumul diseas caus mutat prevent deleteri mutat inherit femal germlin evolv conserv qualiti control mechan remain poor understood larg scale screen uncov uniqu program germlin mitophagi pgm essenti mtdna qualiti control find pgm development trigger germ cell enter meiosi inhibit target rapamycin complex torc identifi role rna bind protein ataxin atx coordin time pgm meiosi show pgm requir mitophagi receptor bnip mitochondri fission translat factor member atg complex mitophagi factor pink parkin addit report sever factor critic germlin mtdna qualiti control show pharmacolog manipul one factor promot mtdna qualiti control
D063306;D004272
T123;T114;T043
36,323,235
mgat inhibitor decreas liver fibrosi inflamm murin nash model reduc bodi weight human adult obes monoacylglycerol acyltransferas mgat import enzym high express human small intestin liver regul triglycerid absorpt homeostasi report treatment bms potent select mgat inhibitor decreas inflamm fibrosi cdahfd stam two murin nonalcohol steatohepat nash model high fat diet treat cynomolgus monkey contrast select diacylglycerol acyltransferas dgat inhibitor bms caus diarrhea phase multipl dose trial healthi human adult obes nct bms safe well toler treatment discontinu due advers event consist find rodent model bms elev plasma long chain dicarboxyl acid indic robust pharmacodynam biomark modul increas gut hormon glp pyy decreas bodi weight human subject data suggest mgat inhibit promis therapeut opportun nash diseas high unmet medic need
D065626;D009765
T047
36,323,234
past present futur physiolog pharmacolog glucagon evolut glucagon seen transit impur prepar insulin develop glucagon receptor agonist use type diabet type diabet glucagon receptor antagonist explor reduc glycemia thought induc hyperglucagonemia howev catabol action glucagon current leverag target rise obes parallel diabet bring pharmacolog glucagon full circl evolut physiolog import glucagon advanc beyond control hepat glucos product incorpor critic role glucagon regul lipid amino acid metabol thus unsurpris studi glucagon left sever paradox make difficult distil hormon simplifi action describ histori glucagon past present suggest direct futur field
D003924;D050416
T047;T025
36,323,233
mitochondri signal transduct analog mitochondria powerhous expir mitochondria live dynam matern inherit energi transform biosynthet signal organell activ transduc biolog inform argu mitochondria processor cell togeth nucleus organell constitut mitochondri inform process system mip three step process mitochondria sens respond endogen environment input morpholog function remodel integr inform dynam network base physic interact diffus mechan produc output signal tune function organell system regul physiolog input output transform allow mitochondria transduc metabol biochem neuroendocrin local system signal enhanc organism adapt explicit focus mitochondri signal transduct emphas role communic mitochondri biolog framework also open new avenu understand mitochondria mediat inter organ process under human health
D008928;D015398
T026;T044;T043
36,323,232
target pdac metabol environ determin got give metabol disrupt mainstay cancer therapi prompt research aim identifi novel metabol target despit strong effect observ cultur three recent studi found pancreat tumor refractori disrupt metabol enzym got reveal complex interact within tumor microenviron bypass convent metabol role
D021441;D010190
T191
36,323,231
emerg direct glucagon base therapi glucagon receptor gcgr essenti regul hepat metabol issu cell metabol sekar et al report endosom protein vpsa uncoupl hepat glucos product lipid metabol alter intracellular local gcgr therebi provid new potenti therapeut direct type diabet
D005934;D003924
T125;T121;T047;T116
36,323,230
kir channel macrophag plastic tumor microenviron divers ion channel dysregul function express tumor microenviron tme issu cell metabol chen et al reveal high intratumor k ion restrict plastic tumor associ macrophag tam inhibit kir potassium channel induc metabol reprogram repolar pro tumor tam tumoricid like state
D059016;D009369
T070;T191
36,323,229
destruct come new growth pore form antimicrobi make pancrea grow gut resid bacteria known regul physiolog distal organ howev mechan behind long distanc communic gut microb distal organ remain unknown issu cell metabol two studi show cell expans pancrea depend bacteri induc antimicrobi produc gut
D001419;D000890
T121;T007
36,323,222
soil self clean capac remov organ compound sub surfac irrig sewag effluent global reus treat sewag effluent irrig purpos increas encourag practic solut mismatch demand avail freshwat resourc reus sewag effluent sub surfac irrig ssi agricultur serv dual purpos suppli water crop diminish emiss contamin emerg concern coec surfac water investig reus real scale cropland ssi use sewag effluent septemb march includ extrem dri year residu follow coec relat physicochem properti quantifi liquid chromatographi coupl high resolut mass spectrometri target coec retriev field non detect coec low persist grow season sub surfac irrig coec spread shallow groundwat rhizospher signific lower concentr found infiltr pipe compar direct next pipe shallow groundwat persist mobil class coec belong class pm low persist low mobil class pm high persist high mobil class show chang amongst remov rhizospher groundwat dri versus normal year coec belong class pm low persist high mobil show high season dynam rhizospher shallow groundwat indic coec break coec class pm high persist low mobil signific build rhizospher next infiltr pipe climat condit dri summer precipit surplus drainag winter strong affect fate coec dri summer infiltr effluent hard dilut result signific higher concentr coec belong class pm pm extrem dri year cumul concentr still signific higher normal year winter precipit surplus remov coec persist mobil class shallow groundwat pipe find signific remov effici rhizospher pipe find except pm next pipe howev find signific remov class rhizospher shallow groundwat even signific accumul pm group persist moder hydrophob coec risk character ratio calcul period time highest normal concentr none singl chemic rcrs one rcr also far one impli suffici safe ambient exposur overal deeper groundwat soil surfac lowest respons sub surfac irrig persist mobil adopt ssi stp effluent reus system care must taken monitor coec moder hydrophob build ssi system deeper groundwat discharg surfac water find signific remov pm pm class class conclus relat high remov effici shown benefit surfac water would otherwis receiv stp effluent direct
D060587;D014874
T081;T131;T070;T082
36,323,221
floccul kinet mechan microalga clay contain suspens differ microalg growth phase interplay microalga clay miner enhanc biolog mediat floccul therebi affect sediment transport suspend particul matter spm water benthic environ interact form larger floc higher settl veloc enhanc spm sink aim studi investig floccul kinet microalga clay suspens elucid mechan associ interact standard jar test experi conduct use various mixtur kaolinit microalg sampl batch cultur chlorella vulgari estim biolog mediat floccul kinet organ matter om composit secret microalga character use liquid chromatographi organ carbon detect system quantit analysi transpar exopolym particl conduct separ two class floccul kinet model base interact flocculi floc also adopt quantit analyz experiment data floccul result floccul kinet test om analys associ data analys ie floc size distribut floccul kinet model show floccul increas om concentr growth phase howev day earli stationari phase floccul kinet start decreas substanti declin day even though amount om main biopolym continu increas result indic adequ quantiti biopolym produc microalg cell growth phase enhanc floc floc attach henc floccul kinet contrast excess quantiti biopolym humic substanc stationari phase enhanc format polymer backbon structur floccul via scaveng particl simultan increas steric stabil product larg number fragment particl
D058086;D048408
T002;T204
36,323,220
suppress cyanobacteri domin uv led tio photocatalysi drink water reservoir mesocosm studi cyanobacteria toxic secondari metabolit present challeng water treatment global studi assess tio immobil onto recycl foam glass bead facil calcin method combin treatment unit nm uv led treatment system deploy mesocosm within eutroph brazilian drink water reservoir treatment unit deploy day suppress cyanobacteri abund time enhanc water qualiti paramet turbid transpar improv respect genom analysi microbiota treat mesocosm reveal composit cyanobacteri communiti affect abund bacteroidet proteobacteria increas cyanobacteri suppress effect treatment zooplankton eukaryot also monitor abund zooplankton decreas chrysophyt alveolata load increas result proof concept studi demonstr potenti full scale reservoir applic advanc oxid process complementari water treatment process
D060766;D000458
T007;T167
36,323,219
rapid photooxid remov iii drink water use fe mn composit oxid fe mn composit oxid fmo wide appli oxid remov iii water howev iii direct reduc manganes oxid decreas oxid capac reusabl therebi great limit applic fmo oxid capac reusabl fmo iii effici improv light radiat effect typic coexist ion ca remov iii also studi produc excit manganes oxid ligand metal charg transfer iron oxid iii complex enhanc iii oxid remov light radiat initi iii concentr g l total concentr respect decreas g l dark uv light sunlight min could reduc guidelin limit drink water g l within min uv light sunlight respect exhibit neglig effect remov effici fmo obvious lower adsorpt capac select v adsorpt coexist ca manganes oxid decreas negat charg fmo surfac therebi improv iii adsorpt oxid fmo exhibit excel reusabl total remov effici still maintain five cycl adsorpt desorpt process uv light work elucid photochem oxid remov mechan fmo iii propos low cost effici method detoxif iii contamin drink water
D060766;D001151;D014874;D018508
T121;T131;T196;T052;T167;T057
36,323,218
nitrat concentr predomin driven human climat soil properti us river nitrat one widespread persist pollut time understand nitrat dynam advanc substanti past decad although predomin driver across gradient climat land use geolog remain elus collat nitrat data river along watersh characterist index develop machin learn model reconstruct long term mean multi year averag nitrat concentr contigu unit state conus train model show similar satisfactori model perform predict nitrat concentr chemic ungaug place accuraci analysi reveal five index driver explain spatial variat mean nitrat concentr five influenti driver nitrogen applic rate n rate urban area urban human driver mean annual precipit temperatur climat driver sand percent sand soil properti driver nitrat concentr undevelop site primarili modul climat soil properti decreas increas mean discharg sand nitrat concentr agricultur urban site increas n rate urban reach appar maxima around kgkm yr around respect result indic nitrat concentr may remain similar increas grow human popul addit nitrat concentr increas even without human input warm escal water demand reduc mean discharg mani place result allud conceptu model highlight impact distinct driver human driver predomin nitrogen input land river climat driver soil properti modul transport transform balanc determin long term mean concentr mechan base insight forecast capabl essenti water manag expect chang climat grow agricultur urban
D045483;D009566
T197;T070
36,323,217
wastewat preinteract acceler photoag dispos box deriv polystyren microplast water discharg natur environ almost microplast mps interact wastewat constitu wastewat treatment plant wwtps studi investig photoag dispos box deriv polystyren ps mediat real wastewat simul case flow wwtps natur water result show wastewat influent pretreat signific enhanc photoag psmps sorption wastewat constitu eg time increas photooxid ultraviolet irradi fulvic acid identifi lead contributor enhanc effect wastewat relat wastewat constitu cl co clay particl depth mechan analysi show observ enhanc critic control photosensit effect wastewat enhanc util psmps ultraviolet energi specif various sorb wastewat constitu generat higher concentr oh clean mps without constitu also reinforc util psmps light energi due increas dispers solut increas hydrophil surfac charg also light shield effect induc wastewat less import studi bridg wastewat sourc mp age fate suggest shorten lifetim micro plastic sampl via wwtp input deepen understand mp pollut environ
D015595;D014874
T033;T131;T042
36,323,216
character microplast septic tank via laser direct infrar spectroscopi microplast mps emerg pollut wide detect atmospher hydrospher lithospher biospher wide spread mps indic effect control differ environment sector urgent need first step meet need identifi occurr mps relev environ howev research mps septic tank report far studi investig distribut characterist mps septic tank size detect limit low detect laser direct infrar spectroscopi result show number mps septic tank reach particlesg dri sludg amount detect sediment one order magnitud higher scum total type mps found septic tank type found sediment scum type scum higher sediment size most account sediment scum respect four shape mps detect septic tank name fiber bead granul fragment studi reveal septic tank sink sourc mps reflect fact mps larg number also abund type thus signific attent paid septic tank base microplast pollut may lead environment health risk without proper control manag
D000080545;D014874
T131;T122
36,323,215
explor recycl agricultur wast high rate remov nitrogen wastewat emphas investig inner drive forc comparison convent liquid carbon sourc studi four typic recycl agricultur wast aw corn cob wheat straw sawdust walnut shell name aw aw aw aw respect select extern solid carbon sourc enhanc remov nitrogen wastewat specif drive mechan thorough investig leach experi show dissolv organ carbon doc releas capac follow order aw aw aw aw rang mgg doc releas aw main consist protein like substanc fulvic acid like substanc humic like substanc aw aw achiev compar x n remov perform liquid carbon sourc sodium acet sa long term denitrif experi two aw denitrif perform reli doc releas aw begin enrich function cazym includ glycosid hydrolas carbohydr esteras involv cellulos hemicellulos decomposit aw function gene gapdh gap pk etc relat glycolysi inner drive forc guarante continu suppli electron donor denitrif relat high abund napab narghi nirk norbc nosz encod nitrat reductas nitrit reductas reductas n reductas assur better denitrif perform sa aw aw group addit denitrif relat function gene relat abund nirbd nrfah associ dissimilatori nitrat reduct much higher aw aw group sa group impli nitrogen remov mechan differ liquid carbon sourc aw base solid carbon sourc system addit glu gltbd glna particip ammonia assimil highest aw group result larg amount organ nitrogen accumul peak concentr approxim mgl final rule altern extern carbon sourc abovement microbi mechan verifi base correl analysi nutrient remov function gene combin host bacteri analysi studi provid valuabl inform understand mechan use aw altern extern carbon sourc promot remov nitrogen wastewat
D062065;D009584
T123;T083;T196;T069
36,323,214
reveal mechan polypyrrol ppi enhanc methan product anaerob digest wast activ sludg anaerob digest ad promis method treat wast activ sludg low methan yield limit larg scale applic addit conduct nanomateri demonstr enhanc activ ad via promot direct interspeci electron transfer diet studi novel conduct polypyrrol ppi prepar effect improv ad perform result show accumul methan product enhanc ppi acidogenesi methanogenesi effici acceler microbi communiti analysi indic abund bacteria associ acidogenesi process signific elev ppi investig metatranscriptom reveal fade fadn gene express key enzym fatti acid metabol high express ppi driven ad suggest ppi promot electron generat acid product methanogenesi metabol gene relat acet util co util methanogenesi also regul ppi illustr ppi facilit util acet electron methanogen archaea thus potenti promot methanogenesi diet
D012722;D011108
T104;T122;T069
36,323,213
dynam intern link dissolv carbon karst river system implic composit origin fate dissolv carbon dc deciph biotic abiot process aquat ecosystem repres critic compon global carbon cycl howev under driver riverin dc dynam intern link yet studi investig fluvial physicochem characterist dissolv inorgan carbon dic speci carbon dioxid co exchang dissolv organ carbon doc composit properti karst river system qijiang southwest china carbon dissolut combin photosynthet uptak could explain dynam dic speci carbon sequestr caus low magnitud partial pressur aqueous co pco atm water air co flux f mmolm yield annual co emiss tg co relat high biolog index bix averag low humif index hix averag indic notabl autochthon process humic like compon predomin doc account mean meanwhil tryptophan like compon also identifi collect doc parallel factor analysi parafac across sampl biolog metabol establish intern linkag dic doc karst river system find highlight biolog process determin dc cycl karst aquat ecosystem
D045483;D060587
T081;T070;T082
36,323,212
vikor base approach evalu river contamin risk caus wastewat treatment plant discharg wastewat treatment plant wwtps rare elimin emerg contamin effluent discharg waterway therefor repres signific contamin sourc deleteri environment risk paper present vikor base model assess contamin risk pose cluster wwtps risk index defin via build membership function embodi perform degre wwtps risk level within framework fuzzi set theori propos approach test use case studi wwtps cluster along pearl river sensit analys carri investig robust model result confirm abil propos approach reveal risk level given treatment point comparison topsi scheme well sensit analysi result substanti consist accuraci reliabl propos approach therefor bound improv decentr manag wwtps induc river contamin
D018508;D014874
T131;T052;T057
36,323,211
thermodynam investig nanoplast aggreg aquat environ studi aggreg behavior polystyren nanoplast ps nps absenc presenc opposit charg particul matter systemat investig wide rang electrolyt condit herein use isotherm titrat calorimetri combin time resolv dynam light scatter provid kinet thermodynam insight np aggreg thermodynam profil homoaggreg heteroaggreg fit use independ site two independ site model respect demonstr differ interact mode aggreg process found contribut solvat entropi signific variabl case thermodynam paramet larg determin thermodynam np aggreg furthermor stabil ps nps natur water matric found correl ionic strength content natur colloid eg metal oxid clay particl result point import consid role thermodynam variabl studi fate nps within various environment condit
D000080545;D053758
T122;T073
36,323,210
synerg role ferrat nitrit trigger wast activ sludg solubilis acidogen ferment effect evalu mechan elucid enhanc anaerob treatment effici wast activ sludg toward prefer resourc recoveri would import requir achiev carbon emiss reduct biosolid minim stabil secur concurr studi demonstr synerg effect potassium ferrat pf nitrit prompt solubilis acidogen ferment toward harvest volatil fatti acid vfas result indic pfnano co pretreat boost time time higher solubilis peak solubl chemic oxygen demand scod mgl singl nitrit pf pretreat respect time time higher vfas product achiev maximum vfas accumul mg codl compar singl pretreat nitrit pf ferment afterward dewater improv simultan acidogen ferment moreov schemat diagram establish illustr mechan co pretreat pf nitrit enhanc vfas generat via increas key hydrolyt enzym metabol function gene express shift microbi biotransform pathway elev abund key microb acidogen ferment furthermor mechanist investig suggest pf addit conduc form relat conduct ferment environ enhanc electron transfer et effici contribut vfas biotransform posit studi provid effect strategi enhanc biodegradationbioconvers effici organ matter potenti profit econom return
D012722;D009573
T123;T197;T121;T069
36,323,209
unravel key drive factor involv cometabol enhanc aerob degrad tetracyclin wastewat cometabol shown great potenti increas engin feasibl microalga base biotechnolog aerob treatment antibiot pollut wastewat yet under mechan involv improv microalg perform remain unknown studi incorpor transcriptom gene network analysi enzymat activ cometabol pathway tetracyclin tc chlorella pyrenoidosa identifi key drive factor result demonstr cometabol construct metabol enzym photosynthet machineri improv electron transport chain activ catalyt enzym result subsequ remov tc coupl format dynam intermedi role identifi metabol enzym degrad tc induc dehydroxyl dehydrogen bond cleavag decarboxyl deamin evalu antibiot remov reclaim water show cometabol decreas total concentr antibiot ng l ng l find highlight applic potenti cometabol increas engin feasibl microalg degrad antibiot wastewat also provid uniqu insight unravel black box cometabol aerob biodegrad
D002708;D058086
T204;T002
36,323,208
benefici role pre post ozon low rate biofiltr ultrafiltr process treat reclaim water previous studi shown combin biolog ozon oxid process achiev greater perform treat natur surfac water process individu work design test ozon graviti driven flow slow rate mh biofiltr ozon gusb process pre treatment reclaim water prior ultrafiltr uf aim produc high qualiti drink water signific reduc degre uf foul result show coupl gusb effect remov aromat compound dissolv organ carbon doc biopolym surfac water addit post ozon great contribut reduct uf membran foul time greater flux regard disinfect product format potenti dbpfp final treat water trihalomethan format potenti thmfp haloacet acid format potenti haafp great reduc thms haa respect relationship dbpfp various spectral index reveal aromat compound amino acid like generat dbps disinfect stage among humic substanc like generat thms low molecular weight carboxyl carbonyl organ compound associ generat haa moreov dosag post ozon stage found influenc direct generat dbps overal studi conduct detail evalu novel multi ozon biofilt uf process treat surfac water result provid valuabl basi subsequ studi larger scale demonstr potenti treatment process practic applic
D018508;D014874;D010126;D060766
T131;T103;T052;T167;T057