PMID
int64 35.7M
36.4M
| Title/Abstract
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36,310,480
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deep learn base fulli autom intellig precis diagnosi melanocyt lesion melanocyt lesion occur surfac skin malign type melanoma high fatal rate serious endang human health histopatholog analysi gold standard diagnosi melanocyt lesion studi fulli autom intellig diagnosi method base deep learn propos classifi patholog whole slide imag wsi melanocyt lesion first color normal base cyclegan neural network perform multi center patholog wsi second resnet neural network base deep convolut network predict model built use wsi decis fusion model cascad calcul averag predict probabl wsi final diagnost perform propos method verifi intern extern test set contain wsi respect experiment result show overal diagnost accuraci propos method reach intern test set exceed extern test set furthermor color normal method adopt superior tradit color statist base stain separ base method term structur preserv artifact suppress result demonstr propos method achiev high precis strong robust patholog wsi classif melanocyt lesion potenti promot clinic applic comput aid patholog diagnosi
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D000077321;D008545
|
T191;T066
|
36,310,479
|
characterist neutrophil extracellular trap produc tran retino acid induc dhl pma stimul extracellular trap releas neutrophil neutrophil extracellular trap net doubl edg sword understand mechan net format great signific diseas treatment howev short lifespan larg individu differ inabl perform gene edit render difficult deciph net format use neutrophil necessari find model cell replac neutrophil studi mechan net format studi use differ concentr moll tran retino acid atra differenti hl cell differ day day detect cell viabil nuclear morpholog cell confirm hl cell differenti neutrophil like cell dhl treat atra least day use immunofluoresc stain detect format net demonstr dhl cell differenti day moll atra could generat net compar produc neutrophil upon phorbol myrist acet pma stimul without histon h citrullin furthermor format net dhl cell nadph depend pad independ consist neutrophil taken togeth observ suggest dhl cell differenti moll atra day use model cell neutrophil studi mechan net format
|
D065206
|
T026
|
36,310,478
|
research three dimension skull repair combin residu inform attent cranial defect may result clinic brain tumor surgeri accident trauma defect skull requir hand design skull implant repair edg skull implant need accur match boundari skull wound various defect manual design cranial implant time consum technic demand accuraci low therefor inform residu attent u net ira unet automat design three dimension skull implant propos paper inform appli field natur languag process field comput vision attent extract inform attent extract attent make model focus locat skull defect inform attent also reduc comput paramet count n log n furthermor inform residu attent construct inform attent residu combin place posit model close output layer thus model select synthes global recept field local inform improv model accuraci speed model converg paper open data set autoimpl use train test effect direct indirect acquisit skull implant result compar analyz experiment part experiment result show perform model robust test set case fromautoimpl dice coeffici hausdorff distanc respect propos model reduc resourc requir run model maintain accuraci cranial implant shape effect assist surgeon autom design effici cranial repair therebi improv qualiti patient postop recoveri
|
D017076;D012886
|
T023;T066
|
36,310,477
|
medic imag super resolut reconstruct via multi scale inform distil network multi scale geometr transform domain high resolut hr magnet reson imag mri comput tomographi ct imag provid clearer anatom detail human bodi facilit earli diagnosi diseas howev due imag system imag environ human factor difficult obtain clear high resolut imag paper propos novel medic imag super resolut sr reconstruct method via multi scale inform distil msid network non subsampl shearlet transform nsst domain name nsst msid network first propos msid network main consist seri stack msid block fulli exploit featur imag effect restor low resolut lr imag hr imag addit previous method predict hr imag spatial domain produc smooth output lose textur detail thus view medic imag sr task predict nsst coeffici make msid network keep richer structur detail spatial domain final experiment result construct medic imag dataset demonstr propos method capabl obtain better peak signal nois ratio psnr structur similar ssim root mean squar error rmse valu keep global topolog structur local textur detail better outstand method achiev good medic imag reconstruct effect
|
D007091;D008279
|
T060;T170;T059;T066
|
36,310,476
|
cascad multi level medic imag registr method base transform deep learn base imag registr deform region complex anatom structur import factor affect accuraci network registr howev difficult exist method pay attent complex anatom region imag time recept field convolut neural network limit size convolut kernel difficult learn relationship voxel far spatial locat make difficult deal larg region deform problem aim two problem paper propos cascad multi level registr network model base transform equip difficult deform region perceptron base mean squar error difficult deform perceptron use slide window float window techniqu retriev regist imag obtain difficult deform coeffici voxel identifi region worst registr effect studi cascad multi level registr network model adopt difficult deform perceptron hierarch connect self attent mechan use extract global featur basic registr network optim registr result differ scale experiment result show method propos paper perform progress registr complex deform region therebi optim registr result brain medic imag good auxiliari effect clinic diagnosi doctor
|
D000465;D016571
|
T170
|
36,310,475
|
research panoram imag reconstruct base oral cone beam comput tomographi automat reconstruct panoram imag effect dental arch curv fit affect integr content panoram imag metal implant patient mouth usual lead decreas contrast panoram imag affect doctor diagnosi paper automat oral panoram imag reconstruct method propos calcul key imag area imag extract fusion algorithm dental arch curv could automat detect adjust small number imag intens distribut teeth bone tissu metal implant imag could adjust reduc impact metal tissu generat high qualiti panoram imag method test case cone beam comput tomographi cbct data good result effect improv qualiti panoram imag
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D054893;D014070
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T060;T023
|
36,310,474
|
rapid femur model method base statist shape model geometr bone model patient import basi individu biomechan model analysi formul surgic plan design surgic guid plate custom artifici joint studi rapid three dimension reconstruct method base statist shape model propos femur combin patient plain x ray film data rapid model individu patient femur geometri realiz averag error reconstruct mm root mean squar error mm averag error femor head diamet cervic shaft angl offset distanc antevers angl reconstruct model mm mm respect compar tradit model method new method could achiev rapid reconstruct femur accur shorter time paper provid new technolog rapid model bone geometri help promot rapid biomechan analysi patient provid new idea select orthoped implant rapid research develop custom implant
|
D021621;D014057
|
T062;T060;T073
|
36,310,473
|
optim segment main vessel coronari angiographi imag via remov overlap pacemak coronari angiographi cag typic imag modal diagnosi coronari diseas hasbeen wide employ clinic practic cag base comput aid diagnosi system accur vessel segment play fundament role howev patient bradycardia usual pacemak frequent interfer vessel segment case segment vessel hard mitig interfer pacemak extract main vessel effect cag imag propos approach first pseudo cag pcag imag generat part cag sequenc pacemak exist local featur descriptor employ regist relat locat pacemak pcag imag target cag imag final combin registr result segment result main vessel pacemak interfer pacemak remov segment main vessel improv propos method evalu base cag imag pacemak acquir clinic practic optim ratio dice coeffici demonstr method remov overlap pacemak achiev improv main vessel segment cag imagesour method becom help compon cag base comput aid diagnosi system improv diagnosi accuraci effici
|
D003936;D010138
|
T060;T074
|
36,310,471
|
research progress resorpt lumbar disc herniat summar research progress resorpt lumbar disc herniat rldh
|
D007405
|
T047
|
36,310,470
|
select upper instrument vertebra long segment fixat adult degen scoliosi review research progress upper instrument vertebra uiv select strategi long segment fixat lsf adult degen scoliosi ad
|
D012600;D013123;D007738
|
T061;T047;T190
|
36,310,469
|
effect xanthohumol load anti inflammatori scaffold cartilag regener goat develop anti inflammatori poli lactic co glycol acid plga scaffold load xanthohumol investig anti inflammatori cartilag regener effect goat
|
D054457;D023822
|
T061;T122
|
36,310,468
|
recombin human bone morphogenet protein porous calcium phosphat cementautolog bone combin platelet rich plasma repair larg bone defect rabbit masquelet techniqu investig optim mix ratio recombin human bone morphogenet protein rhbmp porous calcium phosphat cement pcpc autolog bone bone graft materi repair larg bone defect use masquelet techniqu effect platelet rich plasma prp heal bone defect evalu optim ratio mix bone
|
D055396;D053657
|
T123;T116;T031
|
36,310,467
|
protect effect kaempferol endotheli cell injuri glucocorticoid induc osteonecrosi femor head explor effect kaempferol bone microvascular endotheli cell bmec glucocorticoid induc osteonecrosi femor head gionfh vitro
|
D005938;D010020
|
T039;T109;T125;T047;T046
|
36,310,466
|
repair larg skin defect hand modifi dorsal metacarp arteri revers island flap investig effect modifi dorsal metacarp arteri revers island flap base two adjac recurr branch dorsal metacarp arteri repair larg skin defect hand
|
D005383;D050279;D019651;D017695
|
T061;T023;T037
|
36,310,465
|
clinic applic microdissect thin thoracodors arteri perfor flap repair diabet foot ulcer explor effect microdissect thin thoracodors arteri perfor flap tdap repair diabet foot ulcer dfus
|
D061525;D017719;D019651;D003924;D017695
|
T061;T023;T037;T047
|
36,310,464
|
effect analysi modifi tibial transvers bone transport techniqu combin vancomycin calcium phosphat bone cement local fill cover treatment diabet foot investig effect modifi tibial transvers bone transport techniqu combin vancomycin calcium phosphat bone cement local fill cover treatment diabet foot df
|
D017719;D003920
|
T047
|
36,310,463
|
effect comparison two surgic method treatment intra articular displac calcan fractur older children compar effect open reduct intern fixat plate close reduct intern fixat kirschner wire k wire treatment intra articular displac calcan fractur older children
|
D050723;D002111;D018409;D016512;D007718;D057072
|
T023;T037
|
36,310,462
|
short term effect stage manag treatment complex tibial plateau fractur sever soft tissu injuri evalu short term effect stage manag complex tibial plateau fractur sever soft tissu injuri
|
D017695;D013978
|
T037
|
36,310,461
|
effect shape memori alloy embrac devic treatment vancouv b periprosthet femor fractur analyz effect shape memori alloy embrac devic treatment vancouv b periprosthet femor fractur primari hip arthroplasti
|
D006622;D019644;D057068;D005264
|
T061;T047;T074;T037
|
36,310,460
|
research progress unilater biport endoscopi techniqu treatment lumbar relat diseas review applic research progress unilater biport endoscopi ube techniqu treatment lumbar relat diseas
|
D008159;D013130
|
T023;T020
|
36,310,459
|
learn curv analysi unilater biport endoscop lumbar interbodi fusion analyz learn curv unilater biport endoscop lumbar interbodi fusion ube lif
|
D013123
|
T061
|
36,310,458
|
research learn curv unilater biport endoscopi techniqu associ postop advers event summar characterist learn curv occurr postop advers event develop unilater biport endoscopi ube techniqu compar clinic data earli late patient treat ube techniqu
|
D019299;D008159
|
T061;T023
|
36,310,457
|
imag studi clinic applic unilater biport endoscopi techniqu upper lumbar disc herniat via contralater approach investig relationship boni structur nerv indent ligamentum flavum upper lumbar spine use ct three dimension reconstruct techniqu order guid unilater biport endoscopi ube techniqu via contralater approach treatment upper lumbar disc herniat uldh
|
D007405;D013123
|
T061;T047
|
36,310,456
|
short term effect unilater biport endoscop transforamin lumbar interbodi fusion meyerd degre singl segment lumbar spondylolisthesi investig short term effect unilater biport endoscop transforamin lumbar interbodi fusion ube tlif treatment meyerd degre singl segment lumbar spondylolisthesi
|
D013168;D013123;D013130;D008141;D017116
|
T061;T184;T047;T020
|
36,310,455
|
compar analysi unilater biport endoscop discectomi percutan endoscop lumbar discectomi fenestr discectomi treatment lumbar disc herniat investig effect unilater biport endoscop discectomi ube percutan endoscop lumbar discectomi peld tradit fenestr discectomi fd treatment lumbar disc herniat ldh
|
D017587;D007405
|
T061;T047
|
36,310,454
|
comparison effect unilater biport endoscopi techniqu interlaminar uniport endoscop techniqu treatment l lumbar disc herniat compar effect unilater biport endoscopi ube techniqu interlaminar uniport endoscopi iue techniqu treatment l lumbar disc herniat
|
D007405;D017116;D000072836;D017587
|
T061;T184;T047;T037
|
36,310,453
|
earli effect unilater biport endoscop discectomi combin annulus fibrosus sutur treatment lumbar disc herniat analyz earli effect unilater biport endoscop discectomi ube combin annulus fibrosus sutur treatment lumbar disc herniat ldh
|
D007405;D000070616;D017116;D017587
|
T061;T184;T047;T023
|
36,310,452
|
brief histori global trend chines mission unilater biport endoscopi techniqu current unilater biport endoscopi ube techniqu origin argentina develop south korea rapid grow popular china adopt spinal endoscopi use small camera place insid bodi continu water irrig provid better surgic field less tissu dissect quicker recoveri patient disciplin use spinal endoscopi spinal surgeri becom increas widespread ube techniqu promot popular spinal endoscopi china monoport endoscopi techniqu time biport endoscopi better expans applic accessori incis may provid solut complic spinal diseas chines spine surgeon better understand trend spinal endoscopi seiz opportun rapid evolv spinal healthcar promot popular ube across globe
|
D008159;D013122
|
T023;T047
|
36,310,422
|
vivo visual rnai effici use pumiliofbf protein base report strategi induc gene silenc deliveri small interf rna sirna target specif gene locus cell tissu rna interfer rnai technolog hold potenti power tool rang intract disord therapeut howev reliabl noninvas probe visual sirna deliveri silenc effici becom major obstacl sirna base treatment describ develop rna bind protein pumiliofbf puf base report probe monitor sirna deliveri effici function screen effect sirna target site vivo report consist firefli luciferas fluc gene whose express regul uniqu interact architectur puf protein nano respons element nre target rna show robust rapid increas luminesc signal detect success deliveri sirna enhanc green fluoresc protein egfp p gene mammalian cell liver mice deliveri effici various commerci transfect vehicl quantit evalu report addit also employ vivo bioluminesc imag screen identifi potent sirna target p studi indic posit readout report repres promis indic sirna optim visual advanc develop sirna therapeut product
|
D020868;D008322
|
T045;T015
|
36,310,366
|
hogg rs polymorph prostat cancer risk chines case control studi meta analysi background perform case control studi updat meta analysi assess relationship hogg rs polymorph prostat cancer pca risk materi method recruit pca case healthi control meta analysi relev studi recruit divers databas april genet risk evalu use odd ratio correspond confid interv ci genotyp polymorph genotyp via snapshot genotyp method result case control studi fail identifi associ hogg rs polymorph pca risk negat result also obtain stratifi analys perform base patient prostat specif antigen psa level gleason score well tumor node metastasi tnm stage enlarg sampl size perform restrict updat meta analysi recruit case control studi includ current one result suggest genotyp rs polymorph signific associ elev risk pca genet model heterozygot domin model stratif analysi popul ethnic signific associ polymorph suscept pca found asian popul white popul conclus case control updat meta analysi studi suggest hogg rs polymorph suscept factor pca still need verifi chines popul
|
D045647;D011471
|
T191;T126;T116
|
36,310,365
|
year old boy recurr tracheoesophag fistula surgic remov esophag button batteri background among pediatr popul button batteri ingest signific health risk main treatment ingest esophag button batteri urgent endoscop remov miss delay diagnosi result serious complic outcom literatur high morbid mortal describ case button batteri ingest report case aim encourag physician rais suspicion foreign bodi ingest similar pediatr case review differ manag approach case foreign bodi induc tracheoesophag fistula case report year old boy refer us difficulti swallow solid liquid tactil fever month chest x ray show radiopaqu foreign bodi consist button batteri batteri remov surgic cervic incis follow closur identifi tracheoesophag fistula cervic loop esophagostomi gastrostomi month follow gastrostomi feed recurr tracheoesophag fistula identifi surgic closur esophag anastomosi perform postop esophagogram done day show leak evid tracheoesophag fistula patient start oral feed gastrostomi tube remov conclus even absenc wit ingest persist nonspecif symptom must rais suspicion foreign bodi ingest pediatr age group failur endoscop remov batteri possibl need includ manag algorithm surgic repair frequent describ approach foreign bodi induc tracheoesophag fistula repair
|
D014138;D005547
|
T037;T020;T190;T072
|
36,310,351
|
covid countri innov model safe support high risk patient central australia januari covid pandem reach remot communiti central australia northern territori health central australian region health servic royal fli doctor servic rfds execut covid countri program design triag case implement treatment clinic review individu communiti without need reloc larger centr safe provis care program assess patient factor communitycapac factor triag enact pathway remot live peopl qualifi program declin aeromed retriev provid comprehens clinic support includ administr intraven sotrovimab daili schedul visit affect communiti doctor transport rfds plane evalu program demonstr safe effect way provid complex care cultur safe manner
|
D000086382;D010820;D019035
|
T073;T067;T093;T097;T047;T058
|
36,310,335
|
contribut distemp control habitat expans amur leopard viabil amur leopard panthera pardus orientali critic endang top predat struggl brink extinct due threat canin distemp virus cdv habitat loss inbreed depress develop viabil analysi metamodel combin tradit individu base demograph model epidemiolog model assess benefit altern popul manag action respons multipl distinct threat result show extinct risk manag action taken year differ level inbreed depress reduc risk cdv infect amur leopard low coverag vaccin leopard manag sympatr domest dog could effect improv surviv probabl leopard popul habitat expans ad manag measur popul expand find highlight protect amur leopard necessit multifacet synergist effort control multipl threat togeth may signific escal overal viabil speci especi small isol threaten popul broad model framework could offer critic perspect scientif support conserv plan well specif adapt manag action endang speci around world
|
D004216;D046009;D004217
|
T047;T015;T005
|
36,310,334
|
structur human heterodimer transport fhc lat complex anticalin altern bind protein applic singl particl cryo em cryo em structur determin relat small flexibl membran protein high resolut challeng increas size structur featur bind high affin protein biomolecular target allow better particl align may result structur model higher resolut qualiti anticalin altern bind protein antibodi base lipocalin scaffold show potenti theranost applic human heterodimer amino acid transport fhc lat membran protein complex mediat transport certain amino acid deriv thereof across plasma membran present discuss cryo em structur human fhc lat complex anticalin dvs resolut relat high local map resolut lat substrat bind site togeth molecular dynam simul indic presenc fix water molecul potenti involv shape stabil region final present work expand applic portfolio anticalin widen toolset bind protein promot high resolut structur solut singl particl cryo em
|
D002352;D026905
|
T123;T116
|
36,310,321
|
hone antigen specif cell antibodi discoveri user friend process mine deeper repertoir immun base antibodi discoveri plagu pauciti antigen specif b cell identifi cell akin find needl haystack current emerg technolog effect limit term captur antigen specif repertoir report bulk purif antigen specif b cell benefit offer various antibodi discoveri platform use five differ antigen show hit rate compar convent method also show purif high effici loss antigen specif cell furthermor compar clone cognat chain preserv display librari chain either total b cell tbc antigen specif b cell agsc underw combinatori pair found cognat chain pair clone combinatori clone agsc librari higher frequenc function clone show greater divers sequenc paratop compar clone tbc librari antigen specif b cell select techniqu exemplifi process improv reduc cycl time cost remov undesir clone prior screen increas chanc captur desir rare function clone repertoir
|
D000906;D007114
|
T061;T129;T121;T116
|
36,310,319
|
increas multipl resourc promot competit abil natur non nativ plant invas non nativ plant frequent attribut increas resourc avail still understand main base effect singl resourc plant grown without competit despit fact plant reli multipl resourc usual grow competit multipl resourc affect competit nativ non nativ plant remain larg unexplor two similar common garden experi one china one germani test whether nutrient light avail affect competit outcom term biomass product nativ natur non nativ plant found low resourc avail addit one type resourc non nativ competit nativ howev joint increas nutrient light intens non nativ competit nativ find indic addit multipl resourc could great reduc nich dimension ie number limit factor favor domin non nativ speci also indic habitat experienc multipl global chang might vulner plant invas
|
D058865;D010944
|
T098;T002
|
36,310,318
|
multiscal imag saxifraga paniculata provid new insight yttrium uptak plant yttrium gain import high tech applic togeth rare earth element ree also consid emerg environment pollut alpin plant saxifraga paniculata previous shown display high metal toler intrigu ree accumul potenti studi analys soil grown commerci wild specimen saxifraga paniculata assess accumul shed light uptak pathway laser ablat induct coupl plasma mass spectrometri synchrotron base micro x ray fluoresc spectroscopi use localis within plant tissu identifi coloc element distribut similar commerci wild specimen within root most locat epidermi region transloc low wild individu accumul signific commerci one plant origin observ consist coloc al fe ce plant part except hydathod indic share pathway transloc could explain format stabl organ complex citrat exampl studi provid import insight uptak pathway paniculata generalis plant
|
D008674;D031995
|
T196;T002
|
36,310,293
|
origin structur function transit sex pheromon compon fals widow spider femal web build spider dissemin pheromon web attract mate seek male deposit contact pheromon web induc courtship male upon arriv sourc contact mate attract pheromon compon potenti abil femal adjust web attract remain elus report three new contact pheromon compon produc femal fals black widow spider steatoda grossa n methylvaleroyl butyroyl l serin n methylvaleroyl isobutyroyl l serin n methylvaleroyl hexanoyl l serin compound origin posterior aggreg silk gland induc courtship male web ph depend hydrolys carboxyl ester bond give rise three correspond carboxyl acid attract male carboxyl ester hydrolas ceh present web like mediat function transit contact sex pheromon compon carboxyl acid mate attract pheromon compon ceh activ ph depend femal spider manipul silk ph might also activ adjust web attract
|
D012724;D013112
|
T123;T204
|
36,310,248
|
cappari spinosa var herbacea genom provid first genom instrument divers evolut studi capparacea famili caper bush cappari spinosa l one econom import speci capparacea xerophyt shrub well adapt drought harsh environ howev genet studi speci limit lack refer genom
|
D031484;D031483
|
T168;T002
|
36,310,247
|
best genom sequenc strategi annot complex immun gene famili wildlif biodivers crisi increas impact wildlif diseas anim human health provid impetus studi immun gene wildlif despit recent boom genom wildlif speci immun gene poor annot nonmodel speci owe high level polymorph complex genom organis research past decad half tasmanian devil koala highlight import genom accur immun annot investig diseas wildlif given increas ask minimum level genom qualiti requir effect annot immun gene order studi immunogenet divers set answer question manual annot immun gene marsupi genom monotrem genom determin impact sequenc data type assembl qualiti autom annot accur immun annot
|
D000835;D023281
|
T008;T091
|
36,310,246
|
global atlas bamboo rattan gabr phase ii new resourc sustain develop bamboo fast grow grass plant rattan spiki climb palm essenti forest resourc close link human live livelihood materi cultur sinc ancient time promot genet genom research bamboo rattan comprehens coordin intern project genom atlas bamboo rattan gabr launch gabr achiev great success phase focus investig protect bamboo rattan germplasm resourc phase ii briefli review achiev phase introduc goal phase ii
|
D000076502;D065928
|
T078;T068;T070;T067
|
36,310,243
|
south african lagersttt reveal middl permian gondwanan lakeshor ecosystem exquisit detail continent ecosystem middl permian period million year ago poor understood south africa vertebr fossil record well document time interv plant insect virtual unknown rare global scarciti data hamper studi evolut diversif life preclud detail reconstruct analys ecosystem critic period earth histori introduc new local southern karoo basin produc except well preserv abund fossil novel freshwat terrestri insect arachnid plant within robust region geochronolog geolog biostratigraph context konservat konzentrat lagersttt offer uniqu opportun studi reconstruct southern gondwanan deltaic ecosystem thrive million year ago serv high resolut ecolog baselin toward better understand permian extinct event
|
D017753;D005580
|
T167;T070;T082
|
36,310,240
|
cortic gradient human function similar network captur geometri cytoarchitecton organ map function topolog multifacet perspect relat under cross scale structur principl crucial understand structur function relationship cerebr cortex previous work describ sensori associ gradient axi term coupl relationship structur function larg base singl specif featur mesoscop underpin rare determin show gradient pattern encod function similar network base data human connectom project link cytoarchitecton organ principl spatial distribut primari gradient follow inferior anterior superior posterior axi primari gradient demonstr converg relationship layer specif microscop gene express mesoscop cortic layer thick captur geometr represent myelo cyto architectur base laminar differenti theorem involv dual origin theori togeth find provid gradient describ function topolog import link macroscal function landscap mesoscal laminar differenti principl
|
D002540;D063132
|
T023;T017;T029;T091
|
36,310,239
|
track matricellular protein sparc extracellular vesicl non destruct method evalu lipid base antifibrot treatment uncov complex cellular mechan under hepat fibrogenesi could expedit develop effect treatment noninvas diagnosi liver fibrosi biochem complex extracellular vesicl ev role intercellular communic make attract tool look biomark potenti altern liver biopsi develop solid set method isol character ev differ treat human hepat stellat cell hsc line lx investig biolog effect onto nave lx prove ev play activ role fibrogenesi mine proteom data ev associ protein whose express correl hsc treatment choos matricellular protein sparc proof concept feasibl fluoresc nanoparticl track analysi determin ev base hscs fibrogen phenotyp thus use ev direct evalu efficaci treatment polyenylphosphatidylcholin rich lipid find reduc relat presenc sparc posit ev correl cellular respons lipid base antifibrot treatment relat presenc candid protein marker associ releas ev along provid insight polyenylphosphatidylcholin treatment find pave way precis less invas diagnost analys hepat fibrogenesi
|
D040901;D000067128
|
T026;T091
|
36,310,238
|
paraquat agonist stim increas intracellular calcium level paraquat pq effici herbicid lead high mortal antidot mammal pq produc reactiv oxygen speci ros lead epitheli mesenchym transit emt pulmonari fibrosi type ii alveolar ii cell intrigu strategi reduc ros exhibit limit therapeut effect indic target exist pq toxic herein report pq also agonist stim increas intracellular calcium level particular pq promot stim puncta format associ trpc orai extracellular calcium entri thus intracellular calcium influx studi reveal import p residu stim pq associ facilit stim bind trpc consequ stim trpc rout facilit pq induc emt pulmonari fibrosi well cell death result demonstr pq agonist stim induc extracellular calcium entri increas intracellular calcium level thus promot emt ii cell
|
D010269;D011658
|
T131;T047;T109
|
36,310,237
|
defin cellular complex human autosom domin polycyst kidney diseas multimod singl cell analysi autosom domin polycyst kidney diseas adpkd lead genet caus end stage renal diseas character progress expans kidney cyst better understand cell type state drive adpkd progress analyz eight adpkd five healthi human kidney sampl generat singl cell multiom atlas consist singl nucleus transcriptom singl nucleus epigenom activ proinflammatori profibrot signal pathway driven proxim tubular cell fail repair transcriptom signatur proinflammatori fibroblast collect duct cell identifi gprca marker cyst line collect duct cell exhibit increas transcript factor bind motif avail nf b tead creb retino acid receptor identifi valid distal enhanc regul gprca express contain motif singl cell multiom analysi human adpkd reveal previous unrecogn cellular heterogen provid foundat develop better diagnost therapeut approach
|
D016891;D003560
|
T019;T047;T190
|
36,310,236
|
understand fibrosi pathogenesi via model macrophag fibroblast interplay immun metabol context fibrosi progress biolog condit lead organ dysfunct various clinic set although fibroblast macrophag known key cellular player fibrosi develop comprehens function model consid interact metabolicimmunolog context fibrot tissu set show transcriptom base mathemat model vitro system repres macrophag fibroblast interplay reflect function effect inflamm hypoxia adapt immun context irrevers fibrosi develop associ specif combin metabol inflammatori cue vitro signatur good align transcriptom profil generat laser captur glomeruli cortic tubul interstiti area isol human transplant kidney advanc stage glomerulosclerosi interstiti fibrosistubular atrophi two clinic relev condit associ organ failur renal allograft model describ valid tissu base quantit immun phenotyp biopsi transplant kidney demonstr feasibl conclud combin vitro silico model repres power system medicin approach dissect fibrosi pathogenesi applic specif patholog condit develop coordin target approach
|
D007668;D007674
|
T023;T047
|
36,310,235
|
deep transfer learn cancer drug respons integr bulk singl cell rna seq data drug screen data massiv bulk gene express databas analyz determin optim clinic applic cancer drug grow amount singl cell rna sequenc scrna seq data also provid insight improv therapeut effect help studi heterogen drug respons cancer cell subpopul develop comput approach predict interpret cancer drug respons singl cell data collect clinic sampl use propos scdeal deep transfer learn framework cancer drug respons predict singl cell level integr larg scale bulk cell line data highlight scdeal involv harmon drug relat bulk rna seq data scrna seq data transfer model train bulk rna seq data predict drug respons scrna seq anoth featur scdeal integr gradient featur interpret infer signatur gene drug resist mechan benchmark scdeal six scrna seq dataset demonstr model interpret via three case studi focus drug respons label predict gene signatur identif pseudotim analysi believ scdeal could help studi cell reprogram drug select repurpos improv therapeut efficaci
|
D000970;D009369
|
T121;T191;T109
|
36,310,234
|
extent soil hydraul explain ecohydrolog separ field measur hydrolog tracer indic vari magnitud geochem separ subsurfac pore water potenti convent soil physic alon explain isotop differ preferenti flow tight bound water remain unclear explor physic driver isotop separ use differ model configur soil climat mobileimmobil soil water domain characterist without confound fraction plant uptak effect find simul coarser soil less precipit led reduc separ pore space drainag amplifi separ found larger immobil domain lesser extent higher mobil immobil transfer rate nonetheless isotop separ remain small h across simul indic contrast transport dynam generat limit geochem differ therefor convent soil physic alon unlik explain larg ecohydrolog separ observ elsewher effort aim reduc methodolog artifact refin understand fraction process investig new physiochem mechan need
|
D012987;D014872
|
T070;T167
|
36,310,231
|
function select insulin receptor reveal aptam trap receptor structur activ insulin receptor ir initi cascad conform chang autophosphoryl event herein determin three structur ir trap aptam use cryo electron microscopi agonist aptam select activ metabol signal absenc insulin two aptam agonist ir adopt insulin access arrowhead conform mimick site site insulin coordin insulin bind one site trigger conform chang one protom movement block protom opposit site bind captur two uniqu conform ir similar stalk arrang underli tyr mono phosphoryl py select activ metabol signal aptam posit alloster modul bind opposit side insulin bind modul stabil singl insulin bound ir structur bring two fniii region closer proxim full activ result suggest spatial proxim two fniii end import py multi phosphoryl ir requir addit conform rearrang intracellular domain mediat coordin extracellular transmembran domain
|
D011972;D007328
|
T121;T116;T192;T126;T125
|
36,310,190
|
absolut iodin concentr dynam perfus imag myocardium improv detect poststenot ischaem print dynam heart phantom investig detect capabl myocardi perfus defect dual energi comput tomographi ct technolog use time resolv iodin base map function assess coronari stenosi dynam heart phantom
|
D007455
|
T123;T196;T121
|
36,310,181
|
induc forget unwant memori sublimin reactiv process might facilit forget unwant experi typic requir actual imagin exposur remind event avers carri risk peopl unclear whether awar avers content necessari effect voluntari forget disrupt hippocamp function retriev suppress induc amnes shadow impair encod stabil unrel memori activ near time peopl effort suppress retriev build mechan success disrupt retent unpleas memori sublimin reactiv within amnes shadow critic wherea unconsci forget occur affect memori amnes shadow induc conscious suppress unrel benign neutral memori avoid conscious exposur unwelcom content combin amnes shadow sublimin reactiv may offer new approach voluntari forget bypass unpleas conscious exposur unwant memori
|
D008568;D006624
|
T026;T023;T041
|
36,310,180
|
photodimer induc hierarch asymmetr iontron micropattern micropattern various ion base modal materi offer compel advantag function enhanc iontron pressur sens piezoion mechanorecept skin interfac electrod adhes howev exist pattern techniqu iontron materi suffer low flexibl limit modul capabl herein propos facil robust method fabric hierarch asymmetr iontron micropattern denot haim program regul intern stress distribut local ionic migrat among iontron host result haim arbitrarili regul morpholog region depend ionic electr perform readili made via local photodimer anthracen function ionic liquid copolym denot pil subsequ vapor oxid polymer ethylenedioxythiophen edot base piezoion effect within result distinct dope pedot haim serv scalabl iontron potenti generat success synthes fascin micropattern may acceler develop pattern iontron materi flexibl programm function adapt form
|
D011108;D052578
|
T120;T104;T122;T103
|
36,310,179
|
de novo analysi bulk rna seq data spatial resolv singl cell resolut uncov tissu molecular architectur singl cell resolut could help better understand organ biolog patholog process howev bulk rna seq measur gene express cell mixtur without reveal transcript heterogen spatial pattern singl cell herein introduc bulkspac https githubcomzjufanlabbulkspac deep learn framework base spatial deconvolut algorithm simultan disclos spatial cellular heterogen bulk rna seq data use exist singl cell spatial transcriptom refer use bulk transcriptom valid bulkspac unveil particular spatial varianc immun cell differ tumor region molecular spatial heterogen tissu inflamm induc tumorigenesi spatial pattern novel gene differ cell type moreov bulkspac util perform spatial deconvolut analysi bulk transcriptom data two differ mous brain region deriv hous develop sequenc approach term spatial seq reconstruct hierarch structur mous isocortex also annot cell type identifi origin method mous hypothalamus
|
D059467;D009369
|
T081;T191;T086
|
36,310,177
|
mendelian random account complex correl horizont pleiotropi elucid share genet etiolog mendelian random mr har genet variant instrument variabl iv studi causal effect exposur outcom use summari statist genom wide associ studi classic mr assumpt violat iv associ unmeasur confound ie correl horizont pleiotropi chp aris confound could share gene inter connect pathway under exposur outcom propos mr cue mr correl horizont pleiotropi unravel share etiolog confound estim causal effect identifi iv chp account estim uncertainti iv map cis associ gene enrich pathway inform share genet etiolog under exposur outcom appli mr cue studi effect interleukin multipl traitsdiseas identifi sever gene involv share genet etiolog assess effect multipl exposur type diabet across european east asian popul
|
D057182;D003924
|
T062;T047
|
36,310,176
|
occurr ansam synthesi cyclic peptid amanitin bicycl octapeptid compos macrolactam tryptathionin cross link form handl previous occurr isom amanitin term atropisom postul although total synthesi amanitin accomplish aspect still remain unsolv perform synthesi amanitin analog accompani depth spectroscop crystallograph molecular dynam studi data unambigu confirm synthesi two amatoxin type isom propos term ansam natur structur p ansam ansa select synthes use optim synthet strategi believ describ terminolog also implic mani peptid structur eg norbornapeptid lasso peptid tryptorubin other help unambigu describ conform isomer cyclic peptid
|
D053959;D010456
|
T123;T116
|
36,310,174
|
sexual dimorph estrogen sens skelet stem cell control skelet regener sexual dimorph tissu form cell regul sex hormon number system hormon transcript factor known regul prolifer differenti osteoblast osteoclast mechan determin sexual dimorph differ bone regener unclear explor sex hormon regul bone regener compar bone fractur repair adult male femal mice found skelet stem cell ssc mediat regener femal mice depend estrogen signal sscs male mice exhibit similar estrogen respons mechanist found estrogen act direct ssc lineag mice human regul multipl skeletogen pathway necessari stem cell abil self renew differenti result also suggest clinic applic strategi acceler bone heal use local estrogen hormon therapi
|
D010006;D013234
|
T081;T025
|
36,310,172
|
dysregul soxnrf axi confer chemoradiotherapi resist emerg novel therapeut target esophag squamous cell carcinoma esophag squamous cell carcinoma escc sixth lead caus cancer associ death worldwid dismal overal year surviv rate less standard first line therapi advanc escc concomit chemo radiat therapi ccrt howev patient usual develop resist result unfavor outcom therefor urgent identifi mechan under ccrt resist develop effect treatment strategi
|
D004938;D000077277
|
T191
|
36,310,171
|
bone target deliveri platelet lysat exosom amelior glucocorticoid induc osteoporosi enhanc bone vessel coupl glucocorticoid gcs overus associ decreas bone mass osseous vasculatur destruct lead sever osteoporosi platelet lysat pl pool growth factor gfs wide use local bone repair potent pro regener pro angiogenesi howev still seldom appli treat system osteopathia due lack suitabl deliveri strategi non target distribut gfs might caus tumorigenesi organ
|
D055354;D059630;D010024
|
T026;T047;T025
|
36,310,170
|
memori social experi affect femal fecund via percept fli deposit anim exhibit remark reproduct plastic respons social surround profound fit consequ presenc sex conspecif signal current futur expect competit resourc mate plastic respons elev sexual competit caus exposur sex individu well studi male howev much less known plastic respons femal whether repres sexual resourc competit lead chang invest mate behaviour andor reproduct use drosophila melanogast measur impact experiment vari femal exposur femal prior mate fecund mate deploy physic genet method manipul percept differ social cue sensori pathway reveal potenti mechan involv
|
D012726;D004331
|
T204;T054
|
36,310,169
|
sirp antibodi combin oncolyt virus oh protect tumour activ innat immun reprogram tumour immun microenviron combin oncolyt virus ov immun checkpoint blockad research hotspot shown good efficaci present first attempt combin oncolyt herp simplex virus oh anti sirp antibodi antitumour treatment result provid uniqu insight combin innat immun ov
|
D050504;D050130;D009369
|
T061;T005;T191
|
36,310,168
|
role mind qualiti life person spinal cord injuri cross section studi qualiti life consid overarch psychosoci adapt outcom follow rehabilit person spinal cord injuri literatur suggest qualiti life person spinal cord injuri determin mani person psycholog factor includ mind studi aim identifi direct indirect effect mind qualiti life person live spinal cord injuri
|
D064866;D013119
|
T037;T041
|
36,310,166
|
popul genet analys infer limit genet divers across pvama di domain among plasmodium vivax isol khyber pakhtunkhwa region pakistan plasmodium vivax apic membran antigen pvama import vaccin candid malaria genet composit assess pvama wide rang geographi vital plan antigen base vaccin design malaria
|
D010966;D016780
|
T047;T204
|
36,310,165
|
integr metabolom transcriptom analys synergist effect polymyxin rifampicin combin pseudomona aeruginosa understand mechan antimicrobi action critic improv antibiot therapi first time integr correl metabolom transcriptom pseudomona aeruginosa elucid mechan synergist kill polymyxin rifampicin combin
|
D011550;D011112
|
T007;T195;T116
|
36,310,164
|
glioblastoma cell motil depend enhanc oxid stress coupl mobil sulfurtransferas cell motil critic tumor malign metabol obligatori step shape cell behavior look metabol weak share motil cell across divers genet context patient glioblastoma comput analys singl cell transcriptom thirti patient tumor isol cell high motil potenti highlight metabol specif cell character enhanc mitochondri load oxid stress coupl mobil cystein metabol enzym mercaptopyruv sulfurtransferas mpst function assay patient tumor deriv cell tissu organoid genet pharmacolog manipul confirm cell depend enhanc ros product mpst activ motil mpst action involv protect protein cystein residu damag hyperoxid knockdown translat reduc tumor burden robust increas mice surviv start cell cell analys patient tumor work unravel metabol depend cell malign maintain across heterogen genom landscap
|
D005909
|
T191
|
36,310,160
|
one day versus two day hepat arteri infus oxaliplatin fluorouracil patient unresect hepatocellular carcinoma hepat arteri infus chemotherapi haic oxaliplatin fluorouracil effect unresect hepatocellular carcinoma hcc program folfox haic hcc perform day haic day haic herebi retrospect compar efficaci safeti two treatment regimen explor predict power thymidyl synthas tym enzym involv dna synthesi process metabol fluorouracil
|
D006528;D008113
|
T191
|
36,310,159
|
tempor trend caus specif mortal compar estonia lithuania despit two baltic countri similar histori estonia lithuania diverg life expect trend recent year investig diverg compar caus specif mortal trend
|
D008017;D017202
|
T081;T068;T047;T102
|
36,310,158
|
ambient air pollut associ incid dynam progress type diabet trajectori analysi popul base cohort though associ air pollut incid type diabet td well document evid associ develop subsequ diabet complic post diabet mortal scarc investig whether air pollut associ differ progress outcom td
|
D003924;D000397;D000393
|
T131;T047;T069;T080
|
36,310,157
|
evalu rate hivaid mobil app use featur base applic rate method mobil app rate scale purpos studi evalu hivaid mobil applic use mobil app rate scale mar rate featur applic use new tool call featur base applic rate method farm
|
D063731;D000163;D017216
|
T047;T170;T058
|
36,310,156
|
determin health relat qualiti life recent detoxifi patient sever alcohol use disord health relat qualiti life hrqol import clinic outcom alcohol use disord aud consid relev indic treatment success better understand factor affect hrqol would enabl adjust patient care favour treatment outcom determin hrqol aud remain unclear studi aim describ hrqol aud patient identifi best predictor
|
D011788;D000437
|
T078;T048
|
36,310,155
|
diagnost model develop schizophrenia base peripher blood mononuclear cell subtyp specif express metabol marker signific proport person econom burden schizophrenia attribut late diagnosi misdiagnosi disord novel object diagnost approach could facilit earli detect treatment schizophrenia improv patient outcom present studi aim identifi robust schizophrenia specif blood biomark goal develop accur diagnost model level select serum peripher blood mononuclear cell pbmc marker relev metabol immun function measur healthi control n recent onset schizophrenia patient n use multiplex immunoassay flow cytometri analysi covari reveal signific upregul insulin receptor ir fatti acid translocas cd level helper cell f p q f p q respect well downregul glucos transport glut express monocyt f p q robust predictor monocyt glut helper cell cd use develop diagnost model show leav one cross valid area receiv oper characterist curv auc ci diagnost model valid two independ dataset model abl distinguish first onset drug nave schizophrenia patient n healthi control n auc ci also differenti schizophrenia patient n patient neuropsychiatr condit includ bipolar disord major depress disord autism spectrum disord n auc ci find indic pbmc deriv biomark potenti support accur object differenti diagnosi schizophrenia
|
D012559;D003865;D000067877
|
T048
|
36,310,005
|
intern travel pandem era implic health advic intern travel resum covid pandem radic chang context term regul risk model travel
|
D058873;D000086382
|
T047;T067
|
36,310,004
|
chanc bird eye view general practic registrar experi direct observ direct observ teach assess method general practic train provid import time feedback registrar clinic consult skill registrar perspect direct observ essenti understand util learn aim studi explor registrar experi direct observ identifi key consider use direct observ general practic train
|
D058006
|
T091
|
36,310,003
|
qualit explor burnout prevent reduct strategi general practic registrar burnout intervent traine doctor typic overlook specialti specif factor well presum centralis train model aim studi explor stakehold view burnout intervent within australian general practic train factor pertin
|
D058006;D002055;D010820
|
T091;T097;T048
|
36,310,002
|
support qualiti safeti general practic respons rate comput decis support primari health network phns task support qualiti improv general practic tradit method labour intens lack impact measur aim measur general practition gp respons rate comput decis support point care
|
D058006;D058005
|
T091;T097
|
36,310,001
|
deprescrib proton pump inhibitor proton pump inhibitor ppis indic disord includ peptic ulcer diseas gastro oesophag reflux diseas howev often use longer higher dose recommend indic support evid
|
D000069340;D005764
|
T058;T170;T047
|
36,310,000
|
thought die manag non fatal strangul general practic awar signific nonfat strangul increas health justic set approxim half patient strangl sustain immedi physic injuri strangul potenti signific sequela carotid dissect hypox brain injuri laryng injuri non fatal strangul intim partner increas homicid risk time general practition key role identif educ appropri treatment object aim articl provid understand strangul associ risk inform decis make regard assess investig appropri patient referr safeti net discuss inform patient increas risk futur homicid strangl intim partner may prevent death awar red flag sign symptom subtl bruis petechia signific oedema focal neurolog deficit cognit impair aid decis make regard referr imag well inform document legal purpos
|
D001237;D058006
|
T046;T091
|
36,309,999
|
recognis respond domest famili violenc general practic domest famili violenc dfv often difficult recognis despit high preval communiti general practition requir specialis skill elicit histori dfv remain awar complex pattern dfv respond potenti risk maintain engag part team involv ongo care
|
D017579;D058006;D058005
|
T097;T091;T054;T048
|
36,309,998
|
corneal ulcer general practic patient frequent present general practition gps discomfort red eye due corneal ulcer defin defect corneal epithelium under stroma myriad condit may lead corneal ulcer prompt diagnosi adequ manag need prevent visual morbid
|
D003320;D007634;D058006
|
T047;T091
|
36,309,997
|
beyond heart noncardiac chest pain noncardiac chest pain nccp diagnosi usual made cardiac investig fail demonstr specif diagnosi explain either singl episod recurr episod chest pain
|
D005764;D001523
|
T047;T048
|
36,309,996
|
prevent diabet relat foot ulcer earli detect peripher neuropathi peripher neuropathi peripher arteri diseas diabet relat foot ulcer import risk factor futur amput peopl diabet distal symmetr polyneuropathi complic diabet distal symmetr polyneuropathi result loss protect sensat feet increas risk diabet relat foot ulcer
|
D017719;D003929;D016523;D011115;D003920
|
T047
|
36,309,994
|
art scienc select appropri dress acut open wound general practic acut open wound constitut signific part general practic expand global market dress product select wound dress remain area concern among doctor enter general practic
|
D001458;D058006
|
T074;T091
|
36,309,986
|
effici crisprca base genom edit system alkaliphil bacillus sp n applic engin xylos util lactic acid product alkaliphil consid suitabl chassi tradit neutrophil due excel resist microbi contamin alkaliphil bacillus sp n industri interest strain great potenti product lactic acid alkalin polysaccharid hydrolas engin genet labori time consum homolog recombin studi report success develop crisprca base genom edit system high effici singl gene delet larg gene fragment delet exogen dna chromosom insert moreov base catalyt dead variant cas dcas also develop crispri system effici regul gene express final effici genom edit system success appli engin xylos metabol pathway effici bioproduct lactic acid compar wild type bacillus sp n final engin strain xylr delet ara overexpress achiev increas xylos consumpt lactic acid product respect knowledg first report develop applic crisprca base genom edit system alkaliphil bacillus studi signific facilit function genom studi genom manipul alkaliphil bacillus lay foundat develop robust microbi chassi
|
D000072669;D001407
|
T063;T007
|
36,309,975
|
feasibl accept educ train e resourc support sexual intimaci relationship need older care home resid mix method studi sexual intimaci relationship need often neglect aspect care older adult residenti care facil improv awar knowledg improv attitud need among care staff could enhanc qualiti care lead better outcom resid
|
D006707;D019529
|
T053;T073;T093
|
36,309,974
|
factor associ unmet need support maintain independ later life systemat review quantit qualit evid popul consid unmet need could benefit get necessari support polici effort achiev equit access long term care requir understand pattern unmet need systemat review conduct identifi factor associ unmet need support maintain independ later life
|
D006297;D000375
|
T033;T040;T080
|
36,309,917
|
character remov microplast sewag treatment plant urban nagpur india sewag treatment plant stp act potenti sourc microplast contamin environ presenc microplast sewag treatment plant report globe vari concentr henc current studi intend evalu presenc abund microplast occur sewag treatment plant india sampl process digest densiti separ follow microscop polym identif fourier transform infrar spectroscopi also differ wastewat paramet studi analyz influenc high microplast concentr detect influent mpsl reduc around mpsl effluent concentr microplast sewag sludg mpskg promin plastic type identifi includ low densiti polyethylen polypropylen polyurethan polyvinyl chlorid rayon smaller particl prevail effluent releas around billion particl per day environ suggest current stp effici remov major particl consider need avoid ecolog risk associ
|
D000080545;D014874
|
T131;T122
|
36,309,912
|
jian pi yi shen decoct inhibit mitochondria depend granulosa cell apoptosi rat model pof wide appli tradit chines medicin tcm jian pi yi shen jpys decoct mayb appli cure prematur ovarian failur pof besid chronic kidney diseas ckd vivo experi femal sd week old rat random four group name control group negat control pof model group jpys treatment group triptorelin treatment group posit control jpys group treat jpys decoct oral gkg day triptorelin group treat triptorelin inject mgkg day administr cyclophosphamid ctx mgkg bodi weight establish pof model examin apoptosi mitochondri function target gene askjnk pathway mitochondri fusionfiss express vitro experi kgn human granulosa cell line use cell pretreat ctx gml h follow jpys contain serum h thereaft cell employ assess apoptosi mitochondri function target gene level protein mrna vivo jpys allevi injuri suppress apoptosi pof rat addit jpys improv ovarian function jpys inhibit apoptosi granulosa cell improv mitochondri function activ askjnk pathway vitro jpys inhibit kgn cell apoptosi inhibit askjnk pathway improv mitochondri function effect gs similar jpys pof mitochondri dysfunct occur ovari lead granulosa cell apoptosi jpys decoct improv mitochondri function allevi apoptosi askjnk pathway
|
D016649;D004365
|
T123;T047;T121
|
36,309,909
|
synuclein upregul bim mediat apoptosi negat regul endogen gcn synuclein sheet intracellular protein implic major patholog hallmark parkinson diseas pd sever studi shown overexpress caus dopaminerg cell loss howev role apoptosi remain fulli known therefor studi aim address mechan overexpress model apoptosi correl pd pathogenesi use human hs plasmid character role ectop neuron apoptosi sporad pd vitro found overexpress transcript upregul bim mediat apoptosi neuron sh syy cell interest overexpress inhibit general control non depress gcn histon acetyltransferas hat promot transcript upregul bim consequ co overexpress gcn overexpress model show revers toxic neuron cell vitro find support hypothesi mediat histon deacetyl dopaminerg neuron loss pd moreov studi indic therapeut activationhomeostasi gcn may benefit pd synucleinopathi
|
D009447;D010300
|
T047;T191
|
36,309,899
|
identif valid genet signatur associ age chronic obstruct pulmonari diseas age play essenti role develop chronic obstruct pulmonari diseas copd aim studi identifi valid potenti age relat gene copd bioinformat analysi experiment valid first compar gene express profil age young copd patient use two dataset gse gse gene express omnibus geo identifi age relat differ express gene deg regul regul analyz data cigarett smoke induc copd mous model gse total deg identifi age young copd mice gene increas gene decreas addit function enrich analysi reveal deg activ involv copd relat biolog process function pathway meanwhil six gene identifi core age relat gene copd combin human deg mous deg eventu five six core gene valid regul lung tissu collect age copd patient young copd patient name nkg cklf lrp gdpd cxcl thereinto express nkg cklf negat associ lung function result may expand understand age copd
|
D029424
|
T047
|
36,309,891
|
malignus solid tumorhoz trsul hypereosinophil szindrma hypereosinophil syndrom character chronic eosinophil overproduct result multipl organ damag due eosinophil infiltr mediat releas accord etiolog distinguish myeloprolif disord parasit infect solid tumor cell lymphoma idiopath form case report year old man hospit weight loss leg edema tachycardia laboratori test increas biliari obstruct paramet well extrem leukocytosi eosinophilia highlight start evalu strong suspicion hematolog malign ct scan thorax abdomen pelvi describ hepatosplenomegali multipl intrahepat lesion uncertain solitari cystic lesion tail pancrea abnorm lymph node pleural fluid describ ct imag clinic paramet primarili consist manifest chronic myeloid leukemia howev diagnosi confirm peripher blood smear flow cytometri bone marrow biopsi genet test result continu assess toward solid tumor associ leukemoid reaction core biopsi perform verifi liver lesion biopsi confirm infiltr poor differenti epitheli tumor metastasi pancreatobiliari carcinoma best knowledg first case report hypereosinophil syndrom associ gastrointestin solid tumor hungarian medic literatur draw attent differenti diagnosi extrem leukocytosi eosinophil ratio absenc confirm hematolog diseas import earli biopsi sampl solid lesion orv hetil
|
D017681;D009196
|
T047;T191
|
36,309,890
|
nyakon fogott syncop eset carotid sinus syncop temporari exagger circulatori respons carotid massag character mark drop arteri pressur vari degre bradycardia even asystol last sever second result short last loss conscious relat reflex mediat disord faint precipit parapharyng space occupi lesion manifest prolong episod hemodynam instabl report case hemodynam featur syncop well document case illustr potenti overlap pulseless electr activ syncop simpl noninvas solut frighten symptom also suggest orv hetil
|
D002346;D006323
|
T023;T046;T047
|
36,309,889
|
dentoalveolari elvltozsok vizsglata csrahinny diagnosztizlt betegekben congenit absenc teeth one preval craniofaci malform dental disord hypodontia may present vari degre sever absenc teeth anodontia rare base epidemiolog studi common perman dentit decidu teeth
|
D000848;D014070
|
T019;T023
|
36,309,888
|
interkultur kompetencik fejleszts hatkonyabb betegellt nemzetkzi gygyt kutati egyttmkdsek rdekben globalis world role intercultur compet healthcar increas societi becom multicultur develop compet start medic educ
|
D013337;D004501
|
T065;T097
|
36,309,887
|
nem alkoholo hasnylmirigi elzsrosod klinikai jelentsg pancreat lipid accumul known nafpd non alcohol fatti pancrea diseas gain increas attent last coupl year previous alter mention use differ name undoubt term nafpd still rare use hungarian scientif literatur even proper translat consid difficult pancreat lipid accumul clinic manifest ectop occurr adipos tissu nafpd diagnos differ imag modal although proper quantif pancreat lipid accumul challeng ultrasonographi comput tomographi use clinic practic preval nafpd differ adult popul relat higher frequenc might also observ children adolesc obes nafpd may influenc endocrin exocrin function pancrea clinic studi document close correl nafpd type diabetesmetabol syndrom local consequ pancreat lipid accumul less recogn clinic observ suggest nafpd might play role develop acut chronic pancreat pancreat cancer pancreat exocrin dysfunct therapeut weight loss patient obes due life style modif pharmacolog intervent bariatr surgeri may reduc pancreat lipid accumul import antihyperglycem treatment patient type diabet perform use antidiabet drug provid proper glycaem control even weight loss nafpd relat new clinic entiti rather common probabl underdiagnos basic new data nafpd import clinician work field differ specialti sub specialti intern medicin gastroenterolog diabetolog lipidolog obesitolog surgeri orv hetil
|
D003924;D010182;D024821
|
T047
|
36,309,877
|
regulatori mechan hsp endoplasm reticulum stress pepsin treat laryng epithelium cell laryng cancer cell excess pepsin damag normal laryng epitheli cell laryng cancer lc cell heat shock protein hsp close relat pepsin paper explor differ signific regulatori role hsp endoplasm reticulum stress er level pepsin treat laryng epitheli cell lc cell
|
D059865;D007822
|
T049;T191
|
36,309,864
|
multidisciplinari thyroid eye clinic one stop shop littl known success multidisciplinari thyroid eye diseas ted clinic
|
D011788;D049970
|
T078;T047
|
36,309,863
|
trampolin relat injuri children tertiari pediatr center experi israel grow popular trampolin jump past year led increas trampolin relat injuri risk particular high larg trampolin park attend mani individu various size age
|
D050723;D001265
|
T037
|
36,309,862
|
lower sperm exposur among particip undergo intrauterin insemin associ increas incid gestat hypertens disord gestat hypertens gh disord remain major obstetr problem
|
D007316;D046110;D011225
|
T061;T047;T046
|
36,309,861
|
primari central nervous system lymphoma clinic characterist treatment option therapeut outcom patient singl center experi primari central nervous system lymphoma pcnsl rare aggress non hodgkin lymphoma limit data manag pcnsl outsid clinic trial
|
D016543;D008228
|
T191
|
36,309,860
|
patch test allergi clinic real world experi contact dermat inflammatori skin disord character erythemat prurit rash disord either irrit allerg allerg contact dermat diagnos patch test along patient histori
|
D017449
|
T047
|
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