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biomedical-topic-categorization-validation

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36,309,681
pkd defici induc bronchiectasi porcin adpkd model autosom domin polycyst kidney diseas adpkd preval genet disord main character develop renal cyst well various extraren manifest previous studi shown adpkd relat bronchiectasi pathogen mechan unclear previous studi generat pkd pig simul progress cyst format physiolog alter similar seen adpkd patient
D016891;D001987
T019;T047
36,309,680
applic pedicl greater omentum flap tamponad combin laparoscop fenestr diaphragmat hepat cyst investig efficaci clinic applic advantag oment tamponad vascular pedicl combin laparoscop fenestr treatment diaphragmat hepat cyst
D003560;D008107;D010535;D013896
T061;T190;T060;T033;T047
36,309,679
magnitud associ factor teenag pregnanc among antenat care attende bahir dar citi administr health institut northwest ethiopia worldwid teenag pregnanc develop mani devast complic mother neonat like develop anemia nutrit defici pregnanc induc hypertens preterm babi inadequ weight gain obstruct labor fistula sepsi reproduct health concern adolesc main emphasi area increas intern attent recent year therefor intend assess magnitud associ factor teenag pregnanc bahir dar citi administr health institut northwest ethiopia
D011295;D011253
T033;T058;T040
36,309,678
exploratori assess impact novel risk assess test breast cancer clinic wait time workflow discret event simul model breast cancer clinic across uk long struggl cope high demand novel risk predict tool pinpoint test could help reduc unnecessari clinic referr use earli data expect accuraci test explor potenti impact pinpoint percentag patient meet two week referr target b number clinic overspil appoint generat ie patient return clinic complet requir investig
D001943;D000086382
T047;T191;T067
36,309,677
increas data elasmobranch plasma protein electrophoresi electrophoretogram refer valu determin undul skate raja undulata nursehound shark scyliorhinus stellari maintain human care studi determin plasma protein electrophoresi ppe refer interv two elasmobranch speci undul skate raja undulata nursehound shark scyliorhinus stellari use refer popul undul skate male femal nursehound male femal consid clinic healthi plasma sampl analyz use capillari zone electrophoresi cze
D012860;D012754
T013
36,309,676
elev serum interleukin level potenti indic malari infect sever malaria meta analysi interleukin il proinflammatori cytokin role diseas relat inflamm includ malaria howev report effect il malaria sever inconsist therefor meta analys compar differ il level patient sever malaria patient uncompl malaria healthi control perform
D008288
T047
36,309,675
creat condit effect knowledg broker qualit case studi process improv healthcar inform knowledg privat sector skill individu may aid adopt knowledg frontlin care deliveri worker knowledg broker howev effect broker knowledg limit context work within prove unrecept effort therefor need greater insight contextu condit support individu broker process improv knowledg frontlin care deliveri polici maker organ might generat condit
D019359;D000288
T170;T097
36,309,674
cost util analysi caspofungin fluconazol primari treatment invas candidiasi candidemia ethiopia invas candidiasi andor candidemia icc common fungal infect lead signific health econom loss worldwid caspofungin shown effect fluconazol treat inpati icc howev cost effect caspofungin treat icc ethiopia remain unknown aim assess cost util caspofungin compar fluconazol initi therapi primari treatment icc ethiopia
D058387;D058365
T047
36,309,673
effect adjunct telephon base postnat care matern infant ill greater accra region ghana random control trial global postnat care pnc fraught challeng despit high pnc coverag ghana greater accra region gar matern newborn health outcom great concern neonat post neonat mortal rate gar per live birth respect despit pnc coverag least one pnc pnc within hour post deliveri telephon follow use improv health outcom set howev use improv matern infant health postnat period well known ghana assess effect telephon base pnc infant matern ill select hospit gar
D000359;D011181
T058
36,309,672
use grayscal valu hypoecho lesion match target lesion observ magnet reson imag predict clinic signific prostat cancer analyz grayscal valu hypoecho lesion match target lesion evalu use prebiopsi magnet reson imag mri accord prostat imag report data system pi rad
D011471
T191
36,309,671
predictor prognosi pci relat myocardi injuri chronic total occlus periprocedur myocardi injuri pmi associ major advers cardiovascular event mace percutan coronari intervent pci howev incid predictor prognosi pmi chronic total occlus cto undergo pci remain unclear
D062645;D054059;D006335
T061;T047;T037
36,309,670
satisfactori breed potenti transient elimin beef bull clinic anaplasmosi natur servic breed common us cow calf oper diseas impact bull reproduct perform signific econom consequ produc anaplasmosi may underappreci caus poor reproduct perform bull primari system effect bovin anaplasmosi includ anemia fever weight loss result unsatisfactori reproduct perform object pilot studi evalu breed sound examin bse outcom clinic chang bull upon resolut clinic anaplasmosi anaplasma marginal challeng bull observ clinic diseas infect progress chang breed sound compar uninfect control bull week
D000712;D002418
T047
36,309,669
renal thrombot microangiopathi nephrot proteinuria induc intravitr inject aflibercept diabet macular edema vascular endotheli growth factor inhibitor vegfi use treat malign neoplasm ocular diseas inhibit angiogenesi system use vegfi various side effect includ hypertens proteinuria thrombot microangiopathi advers event due intravitr inject vegfi fulli clarifi although age relat macular degener initi common target intravitr inject vegfi also appli sporad diabet macular edema recent year proteinuria follow intravitr inject vegfi would revers patient diabet mellitus dm howev would difficult determin whether kidney damag aris clinic cours dm intravitr inject vegfi diabet macular edema
D008269;D003930;D009404;D003924;D057049;D006973
T047
36,309,668
need prefer women prior sever preeclampsia regard app base cardiovascular health promot women prior sever preeclampsia increas risk cardiovascular diseas later life compar women normotens pregnanc object studi assess need prefer regard app base cardiovascular health promot
D011225;D063731
T046;T170
36,309,667
tertiari lymphoid structur associ improv surviv earli oral tongu cancer clinic signific tertiari lymphoid structur tlss well document earli oral tongu squamous cell carcinoma otscc
D014062;D000072717;D002294;D009062;D006258
T191;T024
36,309,666
advantag ligat rectum gauz pad band laparoscop anterior resect rectal cancer propens score match analysi difficult maintain suffici tension throughout laparoscop anterior resect total mesorect excis caus declin surgic qualiti use soft inexpens gauz pad band pull rectal tube analyz effect surgeri
D012004;D010535
T060;T191;T061
36,309,665
identif origin tumor vein comparison ceus li rad v v patient high risk compar diagnost perform contrast enhanc ultrasound ceus liver imag report data system li rad v v identifi origin tumor vein tiv
D006528;D008113
T191
36,309,664
estim burden diseas attribut lead exposur north africa middl east region systemat analysi global burden diseas studi lead exposur le attribut death disabl adjust life year dali declin recent decad howev remain one lead public health concern particular region low socio demograph index sdi north africa middl east name region henc aim describ attribut burden le region
D000071219;D008017
T081;T068;T102
36,309,663
explan hand foot mouth diseas case japan use googl trend covid infodemiolog studi coronavirus diseas covid pandem affect common diseas impact hand foot mouth diseas hfmd unclear googl trend data benefici approxim real time statist eas access expect use infect explan inform seek behavior perspect aim explain hfmd case covid use googl trend
D000086382;D006232;D009059
T047;T067
36,309,662
chines never smoker adenocarcinoma lung younger fewer lymph node metastas smoker lung cancer aris never smoker suggest substanti differ lung cancer smoker epidemiolog genet molecular level focus non small cell lung cancer nsclc character lung cancer patient china look demograph clinic differ smoke never smoke subgroup
D002289;D008175;D000230;D002294
T191
36,309,661
medic specialist attitud practic toward childhood vaccin qualit studi armenia childhood vaccin rate armenia high howev anecdot evid suggest health worker may advis vaccin extent reason behind unknown studi use world health organ tailor immun programm approach investig medic specialist vaccin practic
D000079263;D014612
T129;T047;T121;T116
36,309,660
short term efficaci high flow nasal oxygen therapi cardiovascular surgic patient random crossov trial oxygen therapi extub intens care unit icu essenti order maintain adequ oxygen especi patient undertaken cardiovascular surgeri venturi mask vm routin use oxygen therapi icu recent howev high flow nasal cannula hfnc becom avail devic deliv lmin humidifi oxygen aim studi evalu short term efficaci hfnc vm cardiovascular surgic patient
D012131;D063087
T061;T047;T046
36,309,659
coronari arteri calcif patient advanc chronic kidney diseas cardiovascular diseas cvd associ higher morbid mortal rate patient chronic kidney diseas ckd studi shown vascular calcif major predictor cvd vascular calcif ckd popul associ various risk factor chang bone miner metabol link increas risk atherosclerosi therefor aim investig correl vascular calcif bone metabol necessari improv surviv prognosi patient ckd
D051436;D003324;D061205;D002318;D005921
T047
36,309,658
practic general pediatr saudi arabia current status challeng opportun saudi arabia general pediatr serv children year old contribut improv health saudi children
D007396;D010372
T065;T091;T097
36,309,657
mechan strength antibiot load pmma spacer two stage revis surgeri antibiot load polymethylmethacryl pmma bone cement spacer provid high local antibiot concentr patient mobil interim period two stage revis periprosthet joint infect pji studi compar mechan characterist six dual antibiot load bone cement dalbc prepar made three differ pmma bone cement studi main object determin effect time antibiot concentr mechan strength dalbc frequent use spacer fabric set two stage revis pji
D001170;D016459
T047;T046
36,309,656
dna methyl altern stanford acut aortic dissect acut aortic dissect aad life threaten cardiovascular diseas recent studi shown dna methyl may associ patholog mechan aad panorama dna methyl need explor
D019175;D000784
T047;T046;T044
36,309,655
implic extrins intrins apoptot pathway target therapi hepatocellular carcinoma use aptam label viramidin nanoparticl hepatocellular carcinoma hcc global health problem region differ epidemiolog statist co assembl drug nanoparticl target moieti could improv therapeut deliveri anti cancer drug attempt track extrins intrins apoptot pathway hcc cell use viramidin vrm load aptam apt nanoparticl nps apt vrm act target ligandsdrug hcc cell nps character use tem esi ms ftir h nmr result show uniform particl round smooth shape nano scale srb base cytotox perform ic valu measur hcc versus normal cell upon propos treatment flow cytometri techniqu appli determin apoptosi confirm use genet protein analys addit nitric oxid enzym ino analyz examin effect reactiv nitrogen speci rns apoptosi induct present find indic huh cell sensit apt vrm nps hepg cell record lowest ic valu well highest signific increas apoptot cell respect intriguing normal bhk cell record undetect ic valu appli nps confirm target deliveri abil genet express protein level c flip bcl tnf regul fadd caspas caspas caspas bax regul upon treatment apt vrm nps prepar vrm nps label apt could signific elev via activ ino conclus apt vrm nps bioconjug interfer hcc cell mediat extrins intrins apoptosi
D006528;D008113;D053758
T191;T073
36,309,654
rapid simultan detect multipl pathogen lower reproduct tract pregnanc base loop mediat isotherm amplif microfluid chip femal reproduct tract infect rti common sourc vari diseas especi import risk factor pregnanc outcom therefor rapid accur simultan detect multipl pathogen urgent need assist diagnosi treatment rti pregnant women streptococcus agalactia agalactia enterococcus faecali e faecali gardnerella vaginali g vaginali candida albican c albican chlamydia trachomati c trachomati five main pathogen lower genit tract high risk serious consequ clinic demand combin loop mediat isotherm amplif lamp microfluid technolog use develop lamp microfluid chip rapid simpl sensit simultan detect five target pathogen
D044085;D060737
T090;T047
36,309,653
atm kinas inhibitor azd combin irinotecan fluorouracil preclin model colorect cancer azd oral inhibitor atm serin threonin kinas play key role dna damag respons ddr associ doubl strand break topoisomeras inhibitor irinotecan use clinic treat colorect cancer crc often combin fluorouracil fu azd combin irinotecan fu evalu preclin model crc determin whether low dose azd enhanc cytotox irinotecan chemotherapi regimen use clinic
D005472;D015179
T121;T191;T114;T109
36,309,652
interpret phenomenolog analysi experi coupl recoveri psycholog symptom trauma follow traumat childbirth global larg proport birth mother lesser extent partner experi birth trauma year yet access adequ post natal trauma support rare avail untreat birth trauma shown negat impact famili term parent relationship one anoth long term negat consequ child despit drive toward integr mental health support matern servic call provid mental health support coupl rather sole birth mother littl research explor birth coupl find help recoveri birth trauma current research interview six coupl use interpret phenomenolog approach order explor understand support recoveri birth trauma four theme identifi need valid feel paper thin system failur birth trauma alway go part data describ understand parent feel vulner loss trust servic provid support follow birth trauma parent need valid reposit control away healthcar profession consid avail knowledg support option avail discuss clinic implic support parent follow birth trauma explor includ identifi need trauma inform care communic train healthcar profession involv matern care requir sourc therapeut support extern parent dyad order maintain coupl interperson relationship
D008427;D001720
T058;T037
36,309,651
mutat myh gene caus recess cleft palat limousin cattl palat structur separ oral nasal caviti integr essenti feed breath total partial open palat call cleft palat common malform mammal environment hereditari aetiolog general compromis life expect absenc surgic repair new form non syndrom cleft palat aros recent limousin cattl anim refer french nation observatori bovin abnorm sinc sinc number affect anim increas steadili studi undertaken identifi caus diseas
D002972
T019
36,309,650
muscl magnet reson imag abnorm neurolept malign syndrom case report neurolept malign syndrom nms rare occasion fatal undesir reaction dopamin antagonist phenotyp divers owe causat drug classic elev serum creatin kinas describ nms report describ muscular patholog find howev muscl magnet reson imag mri report previous
D014150;D009459
T121;T039;T047
36,309,649
spontan regress colloid cyst third ventricl case report review literatur colloid cyst cc rare benign cyst found third ventricl near foramen monro although role surgic resect well establish symptomat larg size cc remain debat whether surgic remov cc symptom minim symptom necessari
D056364;D020542
T190;T030
36,309,648
sleep durat risk high blood pressur thai adolesc thai nation health examin survey v nhes v sleep durat propos associ high blood pressur howev nationwid studi regard associ adolesc remain limit studi aim explor nation preval high blood pressur among thai adolesc determin associ sleep durat high blood pressur
D006973
T047
36,309,647
establish evalu ct base radiom model aid associ pulmonari cryptococcosi establish ct base diagnost radiom model aid complic pulmonari cryptococcosi evalu diagnost efficaci model
D000163;D003453
T047
36,309,646
comparison effect doubl lumen endotrach tube bronchial blocker lung collaps video assist thoracoscop surgeri systemat review meta analysi meta analysi compar qualiti lung collaps result advers reaction use doubl lumen endotrach tube dlt bronchial blocker bb minim invas thorac surgeri
D001261;D061810;D010612
T061;T184;T059;T047;T046
36,309,645
isol nontubercul mycobacteria speci differ water sourc studi six hospit tehran iran nontubercul mycobacteria ntm ubiquit bacteria natur resist disinfect antibiot colon system suppli drink water therefor studi aim evalu preval ntm drink water six hospit tehran iran
D009165;D060766;D009169
T047;T007;T167
36,309,644
acut heart failur associ toxic shock syndrom due methicillin suscept staphylococcus aureus postpartum period case report systemat literatur review toxic shock syndrom tss caus staphylococcus aureus postpartum period rare life threaten diseas present case acut heart failur initi present tss due methicillin suscept staphylococcus aureus mssa describ clinic characterist systemat literatur review
D012772;D013203;D006333
T047;T046
36,309,643
tandem ccch type zinc finger protein gene cpch chimonanthus praecox promot flower enhanc drought toler arabidopsi ccch type zinc finger protein play import role plant develop bioticabiot stress respons wintersweet chimonanthus praecox popular ornament plant strong resist various stress good materi explor gene resourc stress respons studi isol ccch type zinc finger protein gene cpch mz flower wintersweet perform function analysi purpos identifi gene resourc floral transit stress toler
D017360
T002
36,309,642
sport activ particip subject health status patient total hip arthroplasti via anterolater supin approach case seri studi report publish particip sport activ subject health status total hip arthroplasti via anterolater approach supin posit al tha japanes patient studi assess sport activ particip subject health status well factor potenti associ variabl patient underw al tha
D019644;D013177
T061;T056
36,309,641
neonat hemochromatosi thalassemia case report analysi serum iron regul neonat hemochromatosi caus acut liver failur neonat period most due gestat alloimmun liver diseas gald thalassemia caus hemolyt anemia ineffect erythropoiesi due mutat globin gene although neonat hemochromatosi thalassemia complet differ caus coexist diseas synergist exacerb iron overload report newborn thalassemia develop neonat hemochromatosi respond iron chelat rapid worsen requir live donor liver transplant
D016031;D019190;D013789
T061;T047
36,309,640
full length fruit transcriptom southern highbush vaccinium sp rabbitey v virgatum ait blueberri blueberri vaccinium sp nativ north america breed effort improv blueberri fruit qualiti focus improv trait increas firm enhanc flavor greater shelf life effort requir addit genom resourc especi southern highbush rabbitey blueberri
D029798;D029796
T168;T002
36,309,639
hepat vein doppler critic ill patient reflect central venous pressur right ventricular systol function explor whether hepat vein systol fill fraction sff associ central venous pressur cvp right ventricular rv systol function critic ill patient
D018497
T046
36,309,638
maximum entropi principl composit data composit system repres part whole ubiquit encompass abund protein cell distribut organ natur stoichiometri basic chemic reaction thus central goal understand process emerg behavior compon pairwis interact studi howev challeng two key reason first system complex depend often stochast constitu part second data lie simplex influenc correl
D011506;D001419
T123;T007;T116
36,309,637
genom wide analysi polyamin biosynthesi gene wheat reveal gene express specif involv stre myb element regul polyamin drought polyamin pas consid promis biostimul divers key role growth stress respons plant nevertheless molecular basi role pas complet realiz even unfortun transcript analys biosynthesi pathway various wheat tissu investig normal stress condit research find genom wide analys gene implic pas biosynthesi wheat adc arginin decarboxylas odc ornithin decarboxylas aih agmatin iminohydrolas npl nitrlas like protein samdc adenosylmethionin decarboxylas spds spermidin synthas spms spermin synthas acl thermospermin synthas shown
D011073;D055864
T070;T109
36,309,617
tubb express level sensit neuron activ chang determin microtubul growth kinesin mediat transport microtubul dynam polym tubulin regul cell structur cell divis cell migrat intracellular transport howev function contribut individu tubulin isotyp incomplet understood neuron specif tubulin tubb display highest express around earli postnat period character exuber synaptogenesi although tubb mutat associ neuron diseas includ abnorm inhibitori transmiss seizur activ patient molecular consequ alter tubb level larg unknown likewis unclear whether neuron activ trigger tubb express chang neuron studi initi ask whether chemic protocol induc long term potenti cltp affect microtubul growth express individu tubulin isotyp found grow microtubul tubb express sensit chang neuron activ ask consequ tubb downregul neuron data reveal reduc tubb level acceler microtubul growth axon dendrit remark tubb knockdown induc specif upregul tubb gene express without chang tubulin isotyp found tubb downregul reduc tubulin polyglutamyl increas kifc motil boost transport synapt cargo n cadherin known regul synaptogenesi long term potenti due larg number tubulin isotyp develop appli comput model base mont carlo simul understand consequ tubulin express chang silico togeth data suggest feedback mechan neuron activ regul tubulin express consequ microtubul dynam under deliveri synapt cargo
D014404;D016547
T123;T126;T116
36,309,599
role collision ionize heavi ion acceler high intens laser puls present simul result laser driven acceler gold ion use epoch code recent experi report acceler gold ion mevnucleon strong depend charg state distribut target thick detect highest charg state formula see text simul use development branch epoch ionize show collision ionize import caus charg state beyond z like au
D020450
T196
36,309,598
comparison two differ antisept regard intracutan microbi load preoper skin cleans total knee hip arthroplasti periprosthet infect ppis serious concern total knee hip arthroplasti increas incid prevent ppi preoper skin disinfect key element antisepsi repres import part infect prevent howev specif antisept agent endors relev guidelin purpos retrospect random studi investig differ residu bacteria load approv antisept alcohol base solut addit benzalkonium chlorid bac alcohol base solut addit octenidin dihydrochlorid oct two differ time period consecut patient total knee hip arthroplasti skin sampl surgic site collect skin disinfect bac g solut contain propan ol g benzalkonium chlorid g oct g solut contain octenidin dihydrochlorid g propan ol g propan ol g patient per group follow separ cuti subcuti process cultur perform differ agar plate aerob anaerob environ case bacteria detect microbi identif determin matrix assist laser desorpt ionize time flight mass spectrometri maldi tof ms number contamin sampl compar group addit multipl regress analysi perform examin effect type disinfect bmi age sex rheumatoid arthriti diabet mellitus skin disord smoke status local skin sampl posit bacteria detect total sampl posit bacteria bac group sampl posit oct group p disinfect type signific paramet multipl regress analysi p signific higher contamin rate subcuti shown bac group compar oct group vs p chang bac oct preoper skin cleans hip knee area number posit cultur decreas might caus higher microbicid activ oct therefor use oct preoper cleans may reduc risk ppi hip knee surgeri random control trial requir confirm effect evalu reduc risk ppi
D000891;D019644;D019645;D004202
T061;T121;T131;T167
36,309,596
breed migrat perform metric highlight challeng white nape crane global habitat loss deem major threat wetland bird popul howev under mechan popul declin variat bird vulner throughout annual cycl challeng determin yet critic develop target conserv strategi seven year landscap water avail explain occup breed territori best breed perform migratori perform annual surviv white nape crane grus vipio popul eastern mongolia studi also hatch success egg posit correl water avail addit plant product high ambient temperatur larg number herder famili henc livestock negat affect hatch success high water avail luan major stopov site increas migrat speed crane northbound migrat breed ground contrast water condit favor bird stay longer stopov site southbound migrat increas human densiti reduc use stopov site northbound migrat final crane arriv earli breed ground ambient temperatur high northeast mongolia combin find histor trend key environment factor breed ground explain general declin observ popul crane recent decad extrapol find futur climat predict outlook seem poor unless urgent action taken knowledg mechan under white nape crane popul declin eastern mongolia identifi paper improv effect action
D019985;D001717
T081;T012
36,309,594
evid sweet corn yield loss rise temperatur crop product sensit anomal weather condit veget crop high sensit environment chang use sweet corn data collect field year period estim yield sensit chang grow season temperatur total precipit b estim critic threshold non linear temperatur effect sweet corn yield across divers environ c quantifi yield loss surpass upper temperatur threshold anthesi sweet corn result show grow season temperatur exceed formula see text detriment crop yield addit degre day spent formula see text anthesi reduc crop yield irrig rainf field respect studi show evid sweet corn yield loss across broad spatial domain wake climat chang underscor urgenc acceler crop adapt strategi sustain product high popular crop
D003313;D014675
T168;T002
36,309,593
gender motiv gap contribut differ teach approach femal student motiv learn physic research focus potenti gender differ motiv learn physic aim determin weakest femal motiv compon learn physic contribut differ teach approach use real virtual experi compon motiv learn physic general two approach chosen common use approach physic without clear compar indic femal motiv standard questionnair smtsl student motiv toward scienc learn use measur result show femal student weakest motiv compon learn physic import physic scienc self efficaci virtual experi contribut femal motiv learn physic appli real experi femal student use real experi show fear laugh male peer express doubt self knowledg although appli approach caus improv femal student self efficaci statist signific research result suggest teacher need appli teach approach engag girl encourag learn develop order improv self efficaci motiv compon
D009042;D013334
T078;T098;T080;T081;T041
36,309,592
quasi experiment analysi new mine develop driver deforest zambia mine vital part global mani nation economi mine also potenti drive extens land cover chang includ deforest impact reach far mine understand amount deforest associ mine import conservationist govern mine compani consum yet accur quantif rare appli statist match quasi experiment methodolog along bayesian hierarch general linear model assess impact deforest new mine develop zambia present zambia global signific produc miner mine contribut gross domest product export despit extens deforest mine impact land found evid mine analys increas deforest compar match control site extent forest lost therefor differ would like happen without mine present due driver deforest zambia suggest previous assess base correl methodolog may overestim deforest impact mine howev mine rang impact societi biodivers local environ captur analysi
D003247;D065928
T078;T070;T069;T081;T064
36,309,590
spatial variat veget fire emiss south southeast asia covid pre pandem veget fire common southsoutheast asian sasea countri howev studi focus veget fire chang covid compar pre pandem studi fill inform gap report total fire incid total burnt area type veget burnt total particul matter emiss variat sasea covid pre pandem result short term covid versus non covid year show declin fire count vari ssea except south asia includ afghanistan sri lanka increas cambodia myanmar southeast asia increas fire count covid year burnt area declin compar vari southsoutheast asian countri burn agricultur landscap forest sever patch ssea show decreas fire pandem year compar long term pre pandem record z score greater less two denot statist signific howev countri scale result statist signific ssea z score rang although countri experienc decreas fire count associ mean tpm emiss declin tg stdev stdev tg south asia stdev tg stdev tg south east asian countri studi highlight variat fire emiss use fire manag mitig
D000086382;D005390
T047;T067
36,309,587
loss e cadherin causal patholog chang chronic lung diseas epitheli cell line lung mucos surfac first line defens toxic exposur environment insult integr critic lung health earli find lung epithelium patient chronic obstruct pulmonari diseas copd loss key compon adheren junction protein call e cadherin caus decreas known could due lumin insult structur chang small airway irrespect unknown whether loss e cadherin marker driver diseas report loss e cadherin causal develop chronic lung diseas use cell type specif promot find knockout e cadherin alveolar epitheli type ii type cell adult mous model result airspac enlarg furthermor knockout e cadherin airway ciliat cell club cell increas airway hyperreact demonstr strategi upregul e cadherin rescu monolay integr serv potenti therapeut target
D015820;D029424
T123;T047;T116
36,309,586
exposur low level photocatalyt tio nanoparticl enhanc seed germin seedl growth amaranth crucifer veget titanium dioxid tio one common compound earth use natur form engin bulk nanoparticl nps increas rate howev effect tio nps plant remain controversi previous studi demonstr tio nps toxic plant photocatalyt properti tio produc biohazard reactiv oxygen speci contrast anoth line evid suggest tio nps benefici plant growth verifi argument studi use seed germin amaranth crucifer veget model system intrigu data suggest controversi due dosag effect photocatalyt activ tio nps posit affect seed germin growth gibberellin plant toler rang mgcm wherea overdos mgcm induc tissu damag given plant foundat ecosystem find use agricultur applic sustain develop mainten healthi environ
D053758;D053768
T073
36,309,585
quantit myocardi perfus stress use cmr impair healthi middl eastern immigr without cv risk factor middl eastern immigr constitut grow proport european popul compar nativ swede insulin resist contribut atherosclerosi quantit first pass perfus qfpp use cardiovascular magnet reson cmr detect earli sign cardiovascular diseas cvd aim studi myocardi perfus differ healthi male middl eastern immigr nativ male swede eighteen iraqi twelv swedish born control male never smoker cvd risk factor includ global myocardi perfus rest stress assess use qfpp phase contrast cmr imag coronari sinus flow quantit first pass perfus analysi mean sd demonstr differ rest iraqi swedish male vs mlming p lower perfus adenosin iraqi male vs mlming p myocardi perfus assess coronari sinus flow demonstr similar result differ rest perfus group vs mlming p lower perfus adenosin iraqi group vs mlming p myocardi perfus adenosin stress lower healthi iraqi immigr compar swedish control suggest impair microvascular function risk underestim cvd risk healthi individu middl eastern origin
D055414;D054242
T060;T098
36,309,584
sensor neural network high energi effici analog inform convers work present chip analog inform convers techniqu util analog hyper dimension comput base reservoir comput paradigm process electrocardiograph ecg signal local sensor reduc radio frequenc transmiss three order magnitud instead transmit natur spars ecg signal extract featur chip analog inform convert analyz ecg signal nonlinear reservoir kernel follow artifici neural network transmit predict result propos techniqu demonstr detect sepsi onset achiev state art accuraci energi effici reduc sensor power formula see text test chip prototyp nm cmos
D003246;D016571
T078;T170
36,309,583
effect resili architectur ancient windmil sistan region natur ventil enhanc centuri differ element develop architectur ensur adequ natur ventil residenti unit studi assess differ compon ancient windmil sistan iran structur indoor air qualiti iaq enhanc sever climat scenario defin wind analysi sistan meteorolog data analyz cfd site measur confirm accuraci simul result windmil two deflector face prevail wind signific element addit direct wind toward entranc could form vortic near east west open lead suction ventil alter wind speed angl ms would increas air chang per hour ach respect meanwhil ach higher ashra desir level ach
D014691;D016902
T069;T067;T080
36,309,580
far field ultrason imag use hyperlens hyperlens ultrason imag nondestruct evalu non invas diagnost wide discuss like due lack understand perform well challeng recept elast wavefield past fine featur paper discuss develop applic cylindr hyperlen magnifi subwavelength featur achiev super resolut far field radial symmetr structur compos altern metal water layer use demonstr hyperlen numer simul use studi perform cylindr hyperlens regard geometr paramet imag defect separ subwavelength distanc gain insight construct ultrason domain eleg extens concept cylindr hyperlen flat face hyperlen also discuss pave way wider practic implement techniqu paper also present novel waveguid base recept techniqu use convent ultrason transduc receiv captur wave exit fin hyperlen discret metal hyperlen custom fabric use demonstr first time super resolv imag x magnif ultrason domain propos hyperlen recept techniqu among first demonstr ultrason domain well suit practic inspect result import implic higher resolut ultrason imag industri biomed applic
D014159;D008670
T197;T074
36,309,579
identif antibacteri evalu endophyt actinobacteria luffa cylindrica emerg antibiot resist bacteria limit treatment option led untreat infect therebi necessit discoveri new antibiot battel bacteria natur product endophyt actinobacteria ea serv reservoir discoveri new antibiot therefor current studi focus isol antibacteri properti ea isol luffa cylindrica six strain identifi use morpholog character sem analys rrna gene sequenc root leav plant taxonom classifi streptomycetacea famili first report ea form l cylindrica strain produc chain oval cube cylindr shape spore spini smooth surfac three strain kum b kum b kum b report endophyt first time fifti percent isol isol leav sampl use yecd medium result show sampl time season may affect bacteri divers six strain antibacteri activ least one test bacteria aureus p aeruginosa e coli among strain kum b isol close relat praecox exhibit highest antibacteri activ gram posit negat bacteria kum b kum b kum b isol strong inhibit growth p aeruginosa interest strain isol leav exhibit stronger antagonist activ compar isol root studi reveal isol strain luffa produc plethora bioactiv substanc potenti sourc new drug candid treatment infect
D039903;D029776
T007;T002
36,309,578
photobiochem mechan biomolecul relev germicid ultraviolet irradi nm inactiv virus microorgan ultraviolet light short wavelength region promis candid mitig infect diseas germicid mercuri lamp emit nm krcl excim lamp emit nm sterilis properti work wavelength depend photobiochem mechan investig nm irradi analyz under damag mechan dnarna protein use escherichia coli proteas oligopeptid amino acid plasmid dna nucleosid photorepair damag dna dark revers hydrat uracil phosphoramidit coupl block also investig
D014466;D014467
T061;T070
36,309,577
use andrographi paniculata effect liver biochemistri patient gastrointestin problem thailand covid pandem cross section studi covid pandem healthcar facil suppli access limit announc promot andrographi paniculata adg use treatment mild covid patient thailand misconcept take prevent might occur moreov effect adg liver function test lft establish studi adg use effect lft patient gastrointestin gi problem conduct cross section studi includ gi patient voluntarili fill adg questionnair aug sep lft data visit prior visit avail obtain chang lft within person analyz compar patient without adg consumpt studi period total patient complet survey patient took adg within past month lft data avail patient median alanin aminotransferas alt chang compar prior visit higher adg vs control group vs p increas alt ul vs adg control group respect p factor independ associ increas alt multivari logist regress adg exposur adjust p patient nafld gain weight adjust p conclus one fifth gi patient recent took adg even recommend covid prevent took adg like experi increas alt potenti risk adg consumpt liver function assess
D000086382;D065626
T047;T067
36,309,576
vitro vivo assess antioxid potenti isoxazol deriv previous develop fluorophenyl isoxazol carboxamid deriv synthes scaveng activ dpph free radic inhibitori activ lipas amylas enzym evalu inhibit test enzym weak potent activ observ dpph assay particular compound c demonstr high antioxid potenc ic valu gml respect compar trolox posit control compound ic valu gml base vitro result potent compound chosen vivo evalu antioxid properti use male mice inject intra periton divid four group vivo result reveal total antioxid capac tac obtain mice treat two fold greater mice treat posit control quercetin although biolog preclin investig need perform assess therapeut potenti result studi show promis antioxid activ vitro vivo
D000975;D007555
T123;T121;T109;T039;T044
36,309,575
analys adult transcriptom four differ popul spongi moth lymantria dispar l china usa spongi moth lymantria dispar former known gypsi moth forest pest occur two differ biotyp european spongi moth esm lymantria dispar dispar distribut europ north america asian spongi moth asm consist subspeci lymantria dispar asiatica lymantria dispar japonica distribut china russia korea japan asian biotyp classifi quarantin pest us depart agricultur superior flight abil adult femal compar femal european biotyp identifi gene potenti account differ femal flight capabl two biotyp assembl compar transcript profil two north american popul esm two chines popul asm includ sampl unmat femal adult femal mate oviposit unigen identifi regul asm sampl relat esm includ gene involv egg product contrast unigen regul asm sampl includ gene involv energi product although previous studi found asm femal flight reduc oviposit comparison gene express mate oviposit reveal gene consist regul two asm popul
D009036
T204
36,309,574
gene famili expans antarct wing midg strategi adapt cold environ parochlus steinenii fli insect nativ antarctica elucid molecular mechan under adapt cold environ conduct compar genom analys p steinenii close relat lineag analysi gene famili evolut rapid evolv gene famili involv innat immun system unfold protein respons dna packag protein fold unsatur fatti acid biosynthesi detect gene famili p steinenii specif show phylogenet instabl acyl coa delta desaturas heat shock cognat protein hsc repres gene famili show signatur posit select multipl gene duplic event acyl coa delta desaturas may play pivot role membran fluiditi expand hsc gene may function chaperon thermal sensor cold environ find suggest multipl gene famili expans contribut adapt p steinenii cold environ
D002683
T204
36,309,573
multilay redox base hfo x al tio memrist structur neuromorph comput redox base memrist devic shown great potenti applic neuromorph comput system howev demand devic characterist depend implement comput scheme unifi desir properti one stabl devic still challeng understand extend devic characterist tune stabil crucial develop applic specif design present memrist devic function trilay hfo x al tio tailor stoichiometri hfo x x oper condit devic properti experiment analyz physic base devic model develop provid microscop interpret explain role al layer stabl perform result demonstr resist switch mechan tune area type filament type devic well explain model al layer stabil area type switch mechan control format oxygen vacanc al hfo x interfac estim format energi ev stabil area type devic combin multi level analog switch linear resist chang long retent time without extern current complianc initi electroform cycl combin signific improv compar previous bilay devic make devic potenti interest futur integr memrist circuit neuromorph applic
D016571
T170
36,309,572
two year outcom apollon observ studi intravitr aflibercept monotherapi franc patient diabet macular edema apollon nct prospect observ studi evalu effect intravitr aflibercept ivt afl treatment diabet macular edema dme month routin clinic practic franc primari endpoint mean chang baselin best correct visual acuiti bcva earli treatment diabet retinopathi studi letter month safeti monitor throughout studi patient enrol across particip clinic hospit franc patient follow least month includ effect analys treatment nave previous treat month ivt afl treatment mean standard deviat sd chang bcva baselin letter treatment nave patient p letter previous treat patient p baselin letter mean number ivt afl treatment month treatment nave previous treat patient final analysi apollon studi indic follow month ivt afl treatment routin clinic practic franc treatment nave patient dme achiev signific gain visual acuiti previous treat patient maintain prior visual acuiti gainstrial registr number nct
D008269;D003930;D003920
T047
36,309,570
high gradient magnet field starch metabol result space experi direct plant growth weightless requir understand process establish plant orient manipul gravi phototrop determin direct growth previous experi show high gradient magnet field hgmf induc curvatur root shoot experi brassica rapa verifi gravitrop like induct curvatur possibl space hgmf respons organell amyloplast assess effect space hgmf base gene compar transcript static growth clinorot amyloplast size root tip increas weightless decreas clinorot respons magnet field amyloplast size chang correl reduc amylas transcript space sampl enhanc transcript clinorot mechanostimul weightless opposit effect size amyloplast data show plant perceiv weightless metabol adjust micrograv mechanostimul thus clinorot surrog space research may lead incorrect interpret
D014893;D013026
T070;T057
36,309,568
natur attenu process control groundwat contamin chernobyl exclus zone evid year radiolog monitor chernobyl exclus zone cez contain vast major radionuclid releas accid nuclear fuel particl form present analyz groundwat measur collect monitor network cez cover key aquif year sinc accid new data togeth comprehens analysi histor data show sr remain mobil subsurfac environ groundwat concentr cs pu isotop relat low radiolog concern last two decad sr cs level declin remain stabl time major monitor locat due natur attenu driven gradual exhaust fuel particl sourc geochem evolut groundwat downstream wast dump radionuclid retent surfac soil due absorpt bio cycl decommiss cool pond construct new safe confin unit damag reactor also favor better protect groundwat close chernobyl plant site data confin unconfin aquif well river evid low radiolog risk groundwat contamin outsid cez onsit self settler though sever groundwat contamin hot spot remain vicin unit red forest wast trench surfac water bodi contamin bottom sediment find studi support monitor natur attenu approach groundwat manag cez
D047852;D060587
T081;T068;T070;T082
36,309,567
oligodendroglia emerg player sever form learn memori synapt plastic fundament cellular mechan learn memori recent research reveal myelin form glia oligodendrocyt ol also involv contribut way synapt plastic find integr establish conceptu framework use field learn memori ol progenitor involv long term memori memori consolid work memori recal associ learn also contribut short term memori non associ learn affect synapt transmiss intrins excit axon neural oscil oligodendrogli involv expand field beyond synapt plastic system wide network function precis spike time arriv neural oscil critic inform process storag retriev
D007858;D000069077
T062;T041;T061
36,309,563
associ singl child famili subject health complaint children adolesc number singl child famili increas across develop countri last decad aim examin associ singl child sc subject health complaint shcs iranian children adolesc studi conduct part fifth survey nation surveil program entitl childhood adolesc surveil prevent adult non communic diseas caspian v nation survey includ total student year parent rural urban area provinc iran data demograph characterist lifestyl variabl shcs measur use questionnair world health organ global school base health survey gshs multivari logist regress model use estim odd ratio confid interv ci associ sc shcs data particip avail studi scs frequent shcs irrit ci feel nervous ci headach ci multivari model sc signific increas odd dizzi adjust ci backach complaint associ sc shcs feel low irrit feel nervous difficulti get sleep headach stomachach statist signific p valu result suggest sc may associ higher odd dizzi backach complaint
D059026;D004244
T184;T041
36,309,562
coupl phenotyp chang extinct surviv endem prey communiti threaten invas snake face novel invas predat nativ prey either go extinct surviv exapt phenotyp shift either plastic adapt nativ prey also reflect stress mediat respons invas predat affect bodi condit although multipl nativ prey like present type respons singl invad communiti level studi infrequ invas california kingsnak lampropelti california good exampl explor invas predat effect morpholog bodi condit communiti level invad known local extinct gran canaria giant lizard gallotia stehlini notabl reduc number gran canaria skink chalcid sexlineatus boettger gecko tarentola boettgeri compar set morpholog trait bodi condit ie bodi index ectoparasit load invad uninvad area three squamat found clear evid link lack phenotyp chang extinct g stehlini singl nativ prey show morpholog shift side surviv c sexlineatus boettgeri exhibit phenotyp differ sever morpholog trait could reflect plastic respons contribut capac cope snake bodi condit respons vari among speci indic potenti exist simultan consumpt non consumpt effect communiti level studi highlight import address impact invas predat communiti perspect order gain deeper understand effect nativ ecosystem
D011235;D008116
T014;T054
36,309,557
explor oxygen mediat disinfect medic devic reveal high sensit pseudomona aeruginosa elev oxygen level microbiolog safeti medic devic paramount import patient manufactur alik howev usag medic devic inevit becom contamin microorgan includ opportunist pathogen particular problem devic come contact bodi site carri high bacteri load oral caviti present studi investig whether high oxygen concentr appli disinfect surfac contamin differ gram posit gram negat bacteria show opportunist pathogen exemplifi pseudomona aeruginosa particular sensit oxygen concentr atmospher oxygen concentr observ also show high oxygen concentr appli reduc load p aeruginosa nebul use cystic fibrosi patient particular suscept colon infect bacterium conclud efficaci oxygen mediat disinfect depend bacteri speci durat oxygen exposur oxygen concentr consid observ relev gas mixtur high oxygen content readili appli microbi decontamin howev main challeng oxygen base disinfect approach resid potenti incomplet elimin microbi contamin make combin usag disinfect like ethanol hydrogen peroxid recommend
D004203;D004202
T061;T131;T167
36,309,556
posterior transforamin debrid interbodi fusion instrument multi segment thorac spinal tuberculosi midterm follow studi retrospect studi aim evalu midterm outcom surgic manag multi segment thorac spinal tuberculosi singl stage posterior transforamin debrid interbodi fusion instrument januari octob adult patient thorac spinal tuberculosi involv three level underw singl stage posterior transforamin debrid interbodi fusion instrument mean follow month patient elig final evalu display improv biochem marker pain score month improv physiolog level end treatment visual analogu item short form health survey score signific improv compar preoper valu patient preoper neurolog deficit experienc neurolog improv thorac kyphosi angl decreas signific mean kyphot angl loss record final follow bone fusion observ mean month instrument failur one patient experienc delay incision heal five patient suffer postop intercost neuralgia cure conserv treatment graft failur implant breakag studi show util singl stage procedur combin posterior transforamin debrid interbodi fusion instrument demonstr promis result
D014399;D013123;D007738
T061;T047;T190
36,309,555
optim process seed extract larix decidua mill cone includ evalu seed quantiti qualiti object studi determin number stage cone dri immers yield maximum number high qualiti seed nine variant process conduct differ term dwell time dri chamber water immers time extract variant consist five dri step last h four immers step min dri step follow cone shake purpos made laboratori drum process variant evalu compar term cone moistur content well dynam seed yield qualiti seed obtain various step seed yield coeffici cone mass yield coeffici calcul studi process seed extract describ use lewi empir model second stage dri b coeffici rang relat higher initi final moistur content found cone immers min kg water kg dw lowest moistur content found immers min less kg water kg dw highest seed yield first second step obtain h min variant respect five step variant mean cone yield amount total seed cone seed obtain variant classifi qualiti class procedur recommend commerci seed extract facil consist three h dri step two min immers step cone shake drum maxim seed yield shorter cone extract process maintain accept level seed extract may reduc energi consumpt near
D028221
T002
36,309,554
taxonomi chines hospit applic medic disput resolut medic disput view negat indic health care qualiti patient satisfact howev disput prevent perspect systemat supervis unexplor studi examin hospit cluster base diagnosi relat group drg indic explor associ hospit cluster medic disput health administr data sichuan provinc use twostep cluster analysi perform cluster hospit base drg indic multipl regress analysi conduct evalu relationship cluster incidencenumb medic disput hospit group three drg cluster basic n divers n lengthi n adjust covari divers hospit associ increas probabl medic disput ci divers lengthi hospit associ greater number medic disput irr ci irr ci find highlight cluster level perform hospit monitor futur studi could examin relationship use longitudin design explor way reduc medic disput hospit
D034462;D006761
T093;T073;T054
36,309,552
laser guid techniqu novel method accur acetabular cup align total hip arthroplasti accur cup align without navig total hip arthroplasti tha develop laser guid techniqu major purpos paper introduc techniqu compar accuraci convent manual techniqu clinic outcom disloc rate review laser guid techniqu includ preoper postur adjust intraop angular refer detail manuscript hip patient underw primari tha piriformi spare posterolater approach april march review patient divid three group convent group hip laser guid group hip laser radiograph align guid group hip radiograph inclin ri radiograph antevers ra error evalu disloc rate review hip patient follow year postop absolut valu rira error three group respect indic substanti enhanc accuraci laser radiograph align guid disloc rate convent laser group respect novel laser guid techniqu consider enhanc cup align accuraci suggest potenti applic tha later decubitus posit
D019644;D006622
T061;T074
36,309,551
prognost signific system inflammatori respons marker patient superfici esophag squamous cell carcinoma endoscop resect esophagectomi becom standard treatment superfici esophag squamous cell carcinoma sescc patient may develop diseas progress second primari cancer therapi neutrophil lymphocyt ratio nlr lymphocyt monocyt ratio lmr platelet lymphocyt ratio plr reflect balanc pro cancer inflammatori anti cancer immun respons howev role sescc still unknown consecut enrol patient newli diagnos sescc clinic stage tis tnm treat institut pre treatment nlr lmr plr assess correl clinic factor long term surviv total patient enrol male femal median age year receiv endoscop resect treat esophagectomi chemoradi mean follow period month seventeen patient die escc die second primari cancer year escc specif surviv year overal surviv rate respect lmr p nlr p plr signific correl overal surviv receiv oper characterist curv analysi show optim lmr nlr cut valu respect predict poor prognosi patient high nlr low lmr tend longer tumor length larger circumferenti extens presenc second primari cancer multivari cox regress analysi show presenc second primari cancer hr ci low lmr hr ci independ risk factor poor surviv low pre treatment lmr may non invas pretreat predictor poor prognosi guid surveil program suggest anti cancer immun may play role earli event esophag squamous cancer
D000077277;D004938;D016609;D002294
T191
36,309,550
compar analysi immun respons rfa cryoablat colon cancer mous model immun respons radiofrequ ablat rfa cryoablat cra character compar colon cancer mous model studi conduct research protocol approv nation institut health clinic center anim care use committe balbcj mice inocul ct cell random rfa cra sham treatment mice sacrif day post treatment tumor spleen serum harvest cell death determin caspas immunohistochem tunel stain immun respons analyz use flow cytometri serum cytokin assay immunohistochemistri cell death necrosi apoptosi induc ablat compar rfa cra decreas frequenc system regulatori cell found cra group rfa cra reduc frequenc sever myeloid deriv suppressor cell mdsc subpopul rfa induc pro inflammatori cytokin secret includ tnf il well anti inflammatori cytokin il il cra augment secret wider array cytokin compar rfa pro anti inflammatori properti includ il il il il kc gro tumor microenviron rfa reduc number regulatori cell find observ cra reduct immun suppress via decreas regulatori cell mdsc found induc rfa cra cra augment wider rang cytokin rfa main pro inflammatori also anti inflammatori tumor microenviron rfa demonstr pronounc anti tumor immun delin specif immunomodul induc ablat could inform drug devic develop may play role futur hypothesi driven immunomodulatori paradigm combin immunotherapi drug tumor destruct treatment metastat colon cancer
D017115;D003110;D003452;D000078703
T061;T191
36,309,548
infect control covid hospit examin room healthcar provid vulner infect sever acut respiratori syndrom coronavirus sar cov close proxim patient coronavirus diseas sar cov main transmit via direct indirect contact respiratori droplet airborn transmiss also identifi howev evid environment factor scarc evid base measur minim risk infect clinic set insuffici use comput fluid dynam simul exhal larg small aerosol particl patient otolaryngolog examin room medic procedur requir remov face mask effect cough analyz well humid control environment factor suction devic effect control method result show suction devic minim aerosol exposur healthcar worker effici remov larg small aerosol particl howev cough patient remov effici vari invers particl size humid notabl affect aerosol behavior indic need countermeasur smaller aerosol overal result highlight potenti limit use suction devic protect sar cov futur respiratori infect
D000086382
T047;T067
36,309,547
robust covid mortal predict calcul base lymphocyt count urea c reactiv protein age sex luca chest x ray numer risk tool develop enabl triag sar cov posit patient divers level complex present simplifi risk tool base minim paramet chest x ray cxr imag data predict surviv adult sar cov posit patient hospit admiss analys nccid databas patient blood variabl cxr imag hospit across uk use multivari logist regress initi dataset non random split develop intern valid dataset sar cov posit patient respect extern valid final model conduct accid emerg e admiss suspect sar cov infect separ nhs trust luca mortal score includ five strongest predictor lymphocyt count urea c reactiv protein age sex avail point care rapid turnaround result simpl multivari logist model show high discrimin fatal outcom area receiv oper characterist curv auc roc develop cohort confid interv ci intern valid cohort ci extern valid cohort ci discriminatori power luca increas slight includ cxr imag data luca use obtain valid predict mortal patient within day sar cov rt pcr result low moder high high risk fatal
D000086382
T047;T067
36,309,546
infant infer third parti social domin relationship base visual access intergroup conflict conflict greater number alli opposit improv one success conflict howev alli must awar conflict occur often influenc abl see explor whether infant assess social domin influenc whether social alli visual access episod intergroup conflict experi month old expect agent social domin alli abl wit conflict experi provid support find infant expect agent numer larger group social domin alli unabl wit conflict togeth result suggest infant simpli use heurist numer larger group alway domin import infant abl incorpor social alli abil wit conflict predict social domin group
D012930;D007398
T055;T054;T080
36,309,545
morphometr classif kangaroo bone reveal paleoecolog chang northwest australia termin pleistocen specimen identif backbon archeozoolog research challeng differenti postcrani skelet element close relat wild anim biodivers region prove barrier understand past human forag behaviour morphometr increas employ classifi paleozoolog anim remain howev potenti method discrimin wild anim group yet fulli realis demonstr applic tradit morphometr approach taxonom classifi foot ankl bone kangaroo larg high divers marsupi famili use multipl discrimin analysi classifi archaeolog specimen boodi cave northwest australia identifi presenc two local extinct macropod speci termin pleistocen appear band hare wallabi northern nail tail wallabi pilbara region time provid independ evid ecolog human respons chang climat end last ice age tradit morphometr provid access inexpens non destruct tool paleozoolog specimen classif substanti potenti applic divers wild fauna
D007614;D059552
T083;T015
36,309,544
clinic relev cerk sphk breast cancer associ metastasi drug resist despit numer report alter sphingolipid metabol human cancer clinic signific breast cancer remain obscur previous identifi high level sphingolipid ceramid phosphat sphingosin phosphat gene involv synthesi cerk sphk breast cancer patient present studi aim determin correl cerk sphk clinic outcom well metastasi drug resist marker local tcga cohort analys high confid regulatori interact network construct find associ target gene metastasi drug resist furthermor correl cerk sphk select metastasi drug resist marker valid cohort overexpress cerk sphk associ nodal metastasi late tumor stage high prolifer potenc addit increas cerk express also indic poor patient surviv comput network analysi reveal associ cerk sphk known metastasi marker mmp mmp drug resist marker abcc abcg correl analysi confirm associ target gene marker local well tcga cohort find suggest clinic util cerk sphk potenti biomark breast cancer patient thus could provid novel lead develop therapeut
D001943
T191
36,309,542
near atom non icosahedr averag structur giant virus paramecium bursaria chlorella virus giant virus larg group virus infect mani eukaryot although compon obey overal icosahedr symmetri capsid observ found play critic role viral life cycl ident high resolut structur compon remain unknown determin near atom resolut five fold averag structur paramecium bursaria chlorella virus unexpect found viral capsid possess five major capsid protein variant penton protein variant variant creat vari capsid microenviron associ fiber vesicl previous unresolv minor capsid protein structur reveal ident atom model capsid compon obey overal icosahedr symmetri lead model compon assembl initi capsid assembl model might applic mani giant virus
D000072139;D002708;D017862;D010247
T005;T204;T002
36,309,541
small bowel cleanli capsul endoscopi case control studi use valid artifici intellig algorithm small bowel capsul endoscopi sbce may need perform immedi colonoscopi without addit bowel prepar activ small bowel diseas suspect howev unclear whether small bowel cleanli adequ maintain even sbce perform immedi colonoscopi compar small bowel cleanli score studi group sbce immedi colonoscopi control group sbce alon use valid artifici intellig ai algorithm cut score adequ case sbce polyethylen glycol use includ retrospect among enrol case case studi group mean time last dose purgat administr sbce h studi group h control group seventi five case adequ small bowel cleanli differ two group mean small bowel cleanli score studi group control group studi group better colon prepar result higher small bowel cleanli score p small bowel cleanli also adequ maintain sbce immedi colonoscopi differ time volum purgat administr small bowel cleanli
D053704
T060
36,309,539
valid new instrument assess attitud psychedel general popul although research interest assess attitud psychedel valid instrument exist purpos aim develop examin psychometr properti attitud psychedel questionnair apq sampl croatian general popul cross section web base survey among general popul conduct particip femal graduat high school degre health care worker assess particip abil recogn psychedel substanc use short knowledg test apq consist item four sub scale legal use psychedel effect psychedel risk assess psychedel open psychedel model demonstr best fit confirmatori factor analysi total scale reliabl excel mcdonald ci strong correl similar unvalid measur r p demonstr converg valid observ associ attitud knowledg psychedel r p younger age male gender lower educ status associ higher apq score apq valid reliabl could appli assess educ intervent patient treatment outcom attitud differ group expert encourag valid apq english
D006213
T121;T131
36,309,538
complet blood count base multivari model predict recoveri patient moder covid retrospect studi mani resourc limit countri need effici conveni method assess diseas progress patient coronavirus diseas covid studi develop valid complet blood count base multivari model predict recoveri patient moder covid collect clinic data laboratori test result patient moder covid data categor two subgroup depend laboratori test time univari logist regress covari diagnosi use screen independ factor multifactori logist regress use model build data patient anoth hospit collect extern verif model basophil ci mean corpuscular volum ci red blood cell distribut width ci platelet distribut width ci could combin predict recoveri patient moder covid roc curv show model good discrimin calibr curv show model well fit dca show model clinic use small increas paramet within normal rang suggest improv patient moder covid
D000086382
T047;T067
36,309,536
toxicolog evalu overdos hydroxychloroquin zebrafish danio rerio embryo potenti risk treatment hydroxychloroquin hcq includ qt interv prolong hypoglycemia wide rang neuropsychiatr manifest hematotox potenti genet defect hcq extrem toxic use overdos lead tachycardia hypotens known central nervous system transmiss defect hypokalemia manifest individu mechan excess hcq lead manifest still unclear paper overdos hcq differ concentr use treat zebrafish embryo phenomena like human be obtain increas heart rate nervous system inhibit increas concentr embryo mortal malform rate increas hatch rate decreas situ hybrid show abnorm differenti embryo germ layer format vital organ select embryo treat hcq concentr mortal rate hatch rate malform rate embryo like control group transcriptom analysi although index chang signific molecular chang relat develop heart eye nerv import organ signific studi provid use inform research toxic mechan hcq overdos provid insight guid futur studi human
D015027;D004625
T018;T013
36,309,535
glyphos glyphos base herbicid gbhs induc phenotyp imipenem resist pseudomona aeruginosa gbhs wide use herbicid weed control worldwid potenti affect microorgan role subleth exposur develop antibiot resist pseudomona aeruginosa still fulli investig effect glyphos acid gli five glyphos base herbicid gbhs poe former use co formul suscept imipenem potent carbapenem type antibiot one clinic four non clinic environment p aeruginosa isol studi pre exposur broth cultur co exposur solid media examin p aeruginosa strain gbhs result decreas suscept imipenem carbapenem doripenem meropenem retain effect addit microdilut chequerboard method use examin additiveantagonisticsynergist effect glypo gbhs imipenem determin fraction inhibitori concentr fic index base fic index valu glyphos acid total demonstr potent antagonist effect p aeruginosa strain domin extra sl fozat reduc activ imipenem one strain atcc poe three gbhs effect suscept imipenem consid simultan presenc gbhs imipenem various environment nich detect interact chemic may affect microbi communiti mechan glyphos gbh induc imipenem resist p aeruginosa yet investig
D011550;D006540
T131;T007
36,309,532
patient perspect clinic practic assess predict disabl multipl sclerosi inform provid person multipl sclerosi ms may anticip chang cours diseas explor role set standard patient report outcom pro predict disabl progress ms observ studi conduct two cohort person progress ms pwpms relaps ms pwrms respect associ baselin clinic biochem variabl result ms qualiti life scale musiqol modifi fatigu impact scale mfis beck depress inventori ii bdi ii analyz progress disabl year follow pwrms investig show pro differenti pwrms pwpms cohort lower musiqol higher mfis bdi ii score latter mfis correl disabl pwrms high score physic mfis domain associ wors perform hpt trend tfw sdmt instead cognit mfis domain correl chil cerebrospin fluid biomark progress end studi global mfis bdi ii found independ risk factor disabl independ relaps although pro measur explor alter pwpms baselin mfis discrimin current prospect disabl pwrms identifi patient risk progress
D009103
T047
36,309,531
integr hi c short long read genom sequenc reveal structur germlin rearrang genom structur variant common caus diseas contribut larg extent inter individu variabl detect interpret remain challeng investig individu complex genom rearrang includ germlin chromothripsi combin short long read genom sequenc gs hi c larg scale genom rearrang identifi hi c interact map allow independ assess breakpoint call deriv gs method result genom junction base comprehens breakpoint detect hi c achiev reconstruct whole rearrang chromosom integr inform three dimension organ chromatin observ breakpoint occur frequent expect lamina associ domain lad major reshuffl topolog associ domain tad appli phase rna seq observ enrich gene show allel imbalanc express aig within kb around breakpoint interest aig hit breakpoint display downregul therebi suggest differ mechan play gene disrupt rearrang regulatori inform howev major interpret gene locat kb around breakpoint show signific express chang thus overal robust genom toward larg scale chromosom rearrang
D016678;D002843
T116;T028
36,309,527
trophic nich subterranean popul speleomant italicus determin speci trophic nich clarifi function role within food web prey resourc use relat spatial tempor variabl environment condit inform may result particular use implement conserv plan endang speci cryptic behaviour live place difficult survey present first long term studi trophic nich italian cave salamand speleomant italicus strict protect facult cave speci season exploit surfac environ eg forest area well natur artifici subterranean environ analys diet variat six popul italicus inhabit natur cave survey time full year survey sampl individu subject stomach flush ingest prey identifi enumer furthermor salamand bodi condit also evalu result analys provid first comprehens year round assess diet speleomant speci remark diverg term trophic nich bodi condit observ studi popul found discrep forag activ popul locat differ area specif individu experienc sub optim microclimat condit poor perform forag furthermor found tempor spatial variabl bodi condit individu studi highlight remark high spatial tempor diverg trophic habit conspecif popul featur may repres one major factor promot variabl multipl popul trait
D014562;D020387
T011;T070
36,309,526
singl cell profil reveal distinct adapt immun hallmark mda dermatomyos therapeut implic anti melanoma differenti associ gene posit dermatomyos mda dm autoimmun condit associ rapid progress interstiti lung diseas high mortal aetiolog pathogenesi mda dm still larg unknown describ immun signatur mda dm via singl cell rna sequenc flow cytometri multiplex immunohistochemistri peripher b cell affect lung tissu sampl one patient find strong peripher antibodi secret cell cd cell respons cellular immun hallmark stimul type interferon signal associ metabol reprogram molecular immun signatur mda dm high frequenc circul isg cd cell baselin predict poor one year surviv mda dm patient affect lung find profus immun cell infiltr like contribut pro fibrot respons via type interferon product import type interferon mda dm patholog emphas observ retrospect cohort mda dm patient combin calcineurin janus kinas inhibitor therapi show superior efficaci calcineurin inhibitor monotherapi summari studi reveal key immun pathogen featur mda dm provid potenti basi futur tailor therapi
D003882;D017563;D007370
T129;T047;T121;T116
36,309,524
glutamyl prolyl trna synthetas coordin earli endosom anti inflammatori akt signal akt signal pathway play critic role resolut inflamm howev under mechan anti inflammatori regul signal coordin remain unclear report anti inflammatori akt signal coordin glutamyl prolyl trna synthetas epr upon inflammatori activ akt specif phosphoryl ser epr cytoplasm multi trna synthetas complex induc releas epr epr compartment akt earli endosom via select bind endosom membran lipid phosphatidylinositol phosphat assembl akt signal complex specif anti inflammatori activ event promot akt activ mediat gsk phosphoryl increas anti inflammatori cytokin product epr defici macrophag assembl earli endosom complex consequ exacerb inflamm decreas surviv epr defici mice undergo septic shock ulcer coliti collect find show housekeep protein epr act mediat inflammatori homeostasi coordin compart specif akt signal
D051057;D015398
T126;T116;T044;T043
36,309,522
cdk hyperactiv synthet lethal target braf mutat melanoma melanoma deadliest form skin cancer consid intrins resist chemotherapi near melanoma harbor mutat activ rasmitogen activ protein kinas mapk pathway contribut drug resist via poor describ mechan herein show rasmapk pathway regul activ cyclin depend kinas cdk transcript cdk requir genom stabil find melanoma cell harbor constitut high cdk activ inhibit decreas express long gene contain multipl exon includ mani gene involv dna repair convers result show cdk inhibit promot express short gene exon includ mani growth promot gene regul ap nf b transcript factor inhibit pathway strong synerg cdk inhibitor suppress melanoma growth suggest promis drug combin effect melanoma treatment
D008545;D012878
T191
36,309,521
microfluid space code multiplex nucleic acid detect via crispr casa recombinas polymeras amplif fast inexpens multiplex detect multipl nucleic acid great import human health yet still repres signific challeng herein propos nucleic acid test platform name micar coupl microfluid devic crispr casa multiplex recombinas polymeras amplif one fluoresc probe micar simultan test nucleic acid target microfluid space code detect limit achiev attomol multiplex assay take min demonstr util micar effici detect nine hpv subtyp target valent hpv vaccin show sensit specif test patient sampl risk hpv infect addit also show generaliz approach success test eight clinic relev respiratori virus anticip effect undecor versatil platform wide use multiplex nucleic acid detect
D045522;D009696
T123;T126;T116;T114
36,309,520
valid spanish languag version control allerg rhiniti asthma test allerg rhiniti asthma common diseas frequent coexist refer unifi airway diseas current valid scale spanish allow simultan evalu condit translat portugues spanish therefor perform administ patient age year whose nativ languag spanish present diagnosi allerg rhiniti asthma reliabl valid sensit instrument chang valid carri well valu minim relev clinic differ reliabl evalu use cronbach alpha test carat global ic test retest evalu done pearson correl coeffici ic standard error measur p case carat asthma valu interpret inadequ partial control valu mean adequ control carat global patient evalu carat result would patient condit control minim relev clinic import averag differ found carat scale sd carat scale spanish standardis reliabl valid evalu method patient unifi airway diseas
D065631;D001249
T047
36,309,517
g io protein coupl receptor inhibit beta cell electr excit insulin secret depend na k atpas activ g io coupl somatostatin adrenerg receptor activ stimul cell nka activ result islet ca fluctuat furthermor intra islet paracrin activ cell g io gpcrs nkas cell somatostatin secret slow ca oscil decreas insulin secret cell membran potenti hyperpolar result g io gpcr activ depend nka phosphoryl src tyrosin kinas wherea cell nka function inhibit camp depend pka activ data reveal nka mediat cell membran potenti hyperpolar primari conserv mechan g io gpcr control electr excit ca handl insulin secret
D050417
T025
36,309,516
cell free dna methylom captur distinct local metastat prostat tumor metastat prostat cancer remain major clinic challeng metastat lesion high heterogen difficult biopsi liquid biopsi provid opportun gain insight under biolog use high sensit enrich base sequenc technolog provid analysi plasma dna methylom patient local metastat prostat cancer respect show cell free dna methylom captur variat beyond tumor global hypermethyl metastat sampl observ coupl hypomethyl pericentromer region hypermethyl promot glucocorticoid receptor gene nrc associ decreas immun signatur cell free dna methylom reflect clinic outcom distinguish differ diseas type predict accuraci final show abil predict copi number alter data provid opportun joint genet epigenet analysi limit biolog sampl
D000073888;D011471
T123;T191;T114