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biomedical-topic-categorization-validation

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36,309,859
clinic characterist patient staphylococcus aureus bile infect hepatobiliari system steril micro environ bacteri infect system common associ anaerob well gram posit gram negat bacteria biliari infect staphylococcus aureus poor character
D055624;D013203;D006973
T047;T007
36,309,858
mortal predictor oldest old acut geriatr ward hospit inher serious event oldest old risk complic associ increas exponenti age lead death despit size problem studi dedic determin mortal predictor among hospit older patient particular among oldest old object examin hospit mortal predictor oldest old adult hospit acut geriatr ward
D006760;D006761
T058;T073;T093
36,309,857
rare pediatr cecal anomali lesson pediatr surgeri rare incid case part routin work pediatr surgeon cecal anomali children exampl case object describ present workup manag outcom rare cecal anomali children analyz skill need success treatment
D002429;D045822;D007443
T047
36,309,856
mitig interfer daratumumab immunofix electrophoresi singl center experi use hydrashift kit multipl myeloma mm account approxim hematolog malign monoclon immunoglobulin g kappa igg daratumumab bind cd mm cell detect serum immunofix caus pitfal protein quantif
D007147;D009101
T129;T191;T116
36,309,855
high degre atrio ventricular block follow covid vaccin coronavirus diseas covid pandem result four million death global addit lower respiratori system wide rang major organ injuri report among patient infect covid injuri includ cardiac involv spectrum cardiac manifest includ cardiac injuri heart failur cardiogen shock acut coronari syndrom myocard tachyarrhythmia bradyarrhythmia differ degre atrioventricular block report pathogenesi complic fulli understood differ mechan propos includ direct myocyt injuri interstiti inflamm fibrosi cytokin storm plaqu destabil andor hypoxia mani countri work toward mass vaccin use pfizer biontech bntb covid vaccin includ israel report case high degre atrioventricular block avb follow vaccin covid bntb vaccin
D000086382;D054537
T047;T067
36,309,836
effect acut hyperglycemia baroreflex sensit healthi young adult autonom dysfunct impair baroreflex sensit brs derang circulatori homeostasi observ chronic hyperglycemia found associ increas cardiovascular morbid mortal howev acut effect hyperglycemia healthi subject rare studi present studi explor effect acut hyperglycemia convent unconvent paramet brs healthi young adult
D017704;D006943
T033;T047;T042
36,309,835
note telocyt immun interstiti cell known telocyt describ various organ role normal physiolog pathogenesi numer diseas well known describ context various diseas gallston diseas endometriosi uterin myoma hydronephrosi myocardi infract psoriasi etc impact inflamm involv angiogenesi repair highlight part local homeostasi known relationship immun system secretom genom immun profil contact surround cell specif local allow us give possibl explan involv patholog pathway review aim present role featur telocyt context intestin immun largest bodi spleen interact immunocyt place stem cell nich
D000067170;D056885;D007889
T191;T025
36,309,834
challeng diagnosi acut scrotum remain difficulti insight main target manag male pediatr patient clinic sign acut scrotum time diagnosi order jeopard viabil affect testicl thorough evalu patient medic histori symptomatolog clinic ultrasonograph find constitut basi diagnost procedur comprehens research relev literatur highlight remain difficulti evalu clinic ultrasonograph find accur diagnosi acut scrotum conclus worth emphas follow common diseas come diagnosi acut scrotum may present similar symptom b neglect case diagnost approach becom difficult constitut evalu pathognomon clinic sign challeng c inabl exclud diagnosi spermat cord torsion indic surgic explor affect hemiscrotum
D004823;D013086
T047
36,309,833
physiotherapeut rehabilit adolesc patient temporomandibular disord tmd group patholog chang includ increas tension masticatori muscl pain muscl andor temporomandibular joint abnorm rang mandibular movement presenc acoust symptom joint form click pope aim project compar effect two method physiotherapeut rehabilit use adolesc patient temporomandibular disord
D013705
T047
36,309,832
total ankl arthroplasti use zimmer prosthesi review result previous research conduct field aim articl describ surgic techniqu earli result total ankl replac tar later approach use zimmer tm prosthesi studi use theoret knowledg result research conduct author practic knowledg due fact center perform type oper arthrodesi current standard treatment advanc degen ankl diseas apart advantag also mani disadvantag relat durabl reduct patient pain achiev expens adjac joint acceler arthrosi result compensatori load consequ chang foot biomechan determin implement solut guarante elimin pain ankl joint preserv motor function improv gait negat impact mobil adjac joint
D058737
T061
36,309,831
modul activ fluoropyrimidin colorect cancer vitamin analog colorect cancer crc third common malign worldwid second dead cancer scientist project preval reach million new case annual due popul age disadvantag diet transform elev exposur risk factor past decad five year surviv rate colorect cancer signific increas due develop earli endoscop diagnosi new chemotherapeut approach fluoropyrimidin fluorouracil capecitabin common use treat crc one fundament mechan fu base inhibit thymidyl synthas action respons therapeut also toxic effect drug short review discuss possibl effect vitamin activ colorect cancer cell relat fluoropyrimidin pubm embas web scienc databas search januari studi vitamin fluorouracil interact mechan origin studi case report review articl includ vitamin analog target multipl biochem pathway modul numer pathophysiolog mechan cours colon cancer includ relat pharmacolog site fluoropyrimidin howev avail data concern vitamin fluoropyrimidin pharmacolog interact limit especi regard patient suffer colon cancer treat fluoropyrimidi
D015179;D003110
T191
36,309,830
risk factor develop temporomandibular disord relat work environ literatur review experi articl character etiolog temporomandibular disord particular emphasi emot factor major impact develop dysfunct common symptom main affect peopl third fourth decad life women predomin among group patient articl analyz current literatur pub med databas scopus embas relat condit work environ often constitut import caus emot tension constant state mental tension suscept effect stressor impact state function musculoskelet system masticatori system despit high frequenc temporomandibular disord unfortun studi describ influenc harm factor relat work environ experi inform patient interview data literatur indic signific share factor develop temporomandibular disord relationship anatom connect affect influenc stressor function masticatori muscl temporomandibular joint also discuss conclus state work environ emot tension generat constitut serious sociolog problem increas risk develop intensifi symptom tmd
D013705
T047
36,309,829
anesthesia gynecolog cancer surgeri malign neoplasm current sever medic challeng second lead caus death worldwid modern anesthesia appli may improv patient outcom paper present review anesthesia manag relat patient gynaecolog malign includ influenc type anesthesia cancer recurr applic region anesthesia gynaecolog oncolog surgeri select aspect anesthesia robot surgeri perform literatur search medlin embas googl scholar cochran central regist control trial clinic trial databas search focus topic relat anesthesia gynecolog oncolog author also contribut individu independ literatur search
D000758;D009369
T061;T191
36,309,828
inhibitori effect human plasma albumin haptoglobin platelet aggreg ht releas platelet aggreg contribut pathogenesi cardiovascular diseas activ lead dens granul secret ht releas question aris platelet aggreg endogen control blood circul preliminari studi observ human platelet aggreg rapid suspend buffer compar suspend plasma prp observ point presenc endogen substanc may inhibit arachidon acid induc platelet aggreg analysi plasma cohn fraction demonstr plasma inhibitori activ associ albumin rich globulin rich protein fraction ident plasma endogen inhibitor platelet aggreg eipa establish affin chromatographi cibacron blue fg specif remov albumin associ globulin eipa activ recogn due haptoglobin affin chromatographi column hemoglobin sepharos addit also found distribut eipa activ vari accord sex physiolog state find reveal eipa may act modul arachidon acid metabol sequest fatti acid substrat
D010974;D012701
T123;T109;T043
36,309,803
year old woman acut cholecyst moynihan hump caterpillar configur right hepat arteri identifi laparoscop cholecystectomi background perform cholecystectomi sever variat encount surgeon moynihan hump caterpillar configur right hepat arteri term use describ tortuous right hepat arteri run proxim parallel cystic duct result small short cystic arteri occupi calot triangl report year old woman acut cholecyst moynihan hump caterpillar configur identifi laparoscop cholecystectomi case report year old woman present emerg depart abdomin pain right upper quadrant week associ nausea vomit abnorm warm cold sensat acut cholecyst diagnos ultrasound laparoscop cholecystectomi use port techniqu perform dissect calot triangl larg pulsatil vessel form loop found turn right hepat arteri anatom variat observ procedur call moynihan hump caterpillar configur right hepat arteri surgeri unev patient discharg next day conclus moynihan hump caterpillar configur right hepat arteri rare anomali incid report report shown although moynihan hump caterpillar configur right hepat arteri rare surgeon awar anatom anomali perform gallbladd surgeri prevent arteri damag oper complic
D017081;D041881
T061;T047
36,309,801
head mount dynam visual acuiti g transit effect interplanetari spaceflight technolog develop result earli valid studi introduct dynam visual acuiti dva refer abil eye discern detail move object play import role whenev rapid physic respons environment chang requir perform task onboard space shuttl signific decreas dva previous note astronaut return long durat spaceflight eye chart line h return space part nasa fund head mount multimod visual assess system monitor vision chang spaceflight elabor upon technic develop engin dynam visual acuiti assess virtual realiti vr technolog first step assess astronaut perform undergo g transit effect also report result earli valid studi compar vr dva assess tradit comput base dva assess method various vrar headset util implement dva test headset includ htc vive pro eye system epic game engin unrealengin version use build framework steamvr use experi virtual realiti content eye track technolog use maintain fixat particip earli valid studi five particip conduct compar technolog versus tradit dva laptop result head mount technolog develop assess dva chang g transit fulli function result earli valid studi demonstr two dva test laptop base vr indic strong associ method pearson correl coeffici bland altman plot employ assess level agreement data point fall within limit agreement discuss result earli valid studi indic head mount dva assess perform similar tradit laptop base method promis method assess dva spaceflight particular g transit futur studi requir assess valid reliabl technolog eas use access portabl design vr dva potenti near futur replac convent method assess dva technolog like import aspect help monitor function safeti interplanetari mission astronaut expos g transit waisberg e ong j zaman n kamran sa lee ag tavakkoli head mount dynam visual acuiti g transit effect interplanetari spaceflight technolog develop result earli valid studi aerosp med hum perform
D000067896;D013026
T170;T057
36,309,799
genet marker atop dermat risk screen aviat applic introduct atop dermat ad skin condit mani genet risk factor review summar differ genet variant ad perspect screen purpos within us air forc aviat communiti use prisma inform systemat review approach found paper report genet associ ad report genet associ ad greater twofold increas odd develop condit present variant found associ gene includ lrrc ovol il replic studi well rtel znf replic studi polygen risk model creat base upon variant gene could contribut risk screen protocol militari aviat candid potenti help minim risk candid increas genet risk ad atop diseas eg asthma allerg rhiniti gregori id colli j chapleau rr genet marker atop dermat risk screen aviat applic aerosp med hum perform
D003876;D065631;D001249;D001359
T089;T090;T047;T056
36,309,795
mitig risk altitud chamber train introduct altitud chamber use train aircrew hypobar hypox environ better prepar pressur oxygen malfunct incid flight howev advers effect may occur train session decompress sick dcs major concern aim studi examin risk differ advers effect altitud chamber train act isra air forc iaf facil compar train facil method retrospect review record individu iaf train altitud chamber data regard advers effect train safeti extract literatur review altitud chamber train perform advers effect rate compar result total advers effect case iaf studi period overal risk rate advers effect common advers effect middl ear sinus barotrauma advers effect case follow breath problem dcs case conclus mitig risk dcs major concern act recommend set standard protocol act includ min preoxygen period maxim ascent rate ft min min set maximum altitud ft fix wing traine nakdimon ben ari mitig risk altitud chamber train aerosp med hum perform
D000337;D003665;D001469
T047;T091;T037
36,309,794
attent network chang high altitud migrant introduct present studi aim explor whether chang alert orient execut network effici attent function high altitud immigr low altitud resid method event relat potenti erp acquir attent network test ant high altitud ha group compris colleg student immigr born rais low altitud live ha ft mo test conduct return ha mo low altitud la group compris colleg student never visit ha area result compar la group ha group higher puls rate lower oxygen satur level decreas alert orient effect behavior result erp result ha group show smaller p occipit area larger n pariet occipit area alert network smaller p larger n orient network la group execut control network n amplitud ha group negat p amplitud ha group decreas incongru condit discuss togeth find suggest high altitud migrant less effect alert orient low altitud resid execut control function chang p amplitud incongru condit indic decreas conflict inhibit under execut control network x tao g zhang x h wang attent network chang high altitud migrant aerosp med hum perform
D000531;D014171
T081;T098
36,309,791
person trait comparison pararescu personnel elit athlet introduct pararescu personnel pjs deploy high risk environ perform extraordinari mission intens condit requir unusu combin physic psycholog abil rigor natur pj train superior level fit cognit function perform challeng physic feat high pressur high intens environ prompt militari command embed health care provid compar success perform pj mission characterist requir elit olymp level athlet method current studi test assumpt compar social emot behavior function us pj train candid graduat elit olymp level track field athlet use score neo person inventori result result studi suggest although physic psycholog challeng inher pj elit athlet career field emot social behavior perform pjs differ function way elit athlet popul pjs score signific lower neurotic higher extravers conscienti discuss result studi use improv deliveri embed mental health servic gear toward improv train enhanc health recoveri perform within oper unit shadl wait l chappell w person trait comparison pararescu personnel elit athlet aerosp med hum perform
D013177;D008889
T056;T097
36,309,790
potenti neuromuscular electr stimul bone loss countermeasur micrograv introduct futur long durat spaceflight mission addit method load skeleton may requir supplement exercis minim bone loss neuromuscular electr stimul nmes elicit muscular contract creat strain bone howev potenti effect nmes proxim femur disus known method measur maximum isometr forc nmes induc contract rectus femori hamstr subject male femal sit hip knee degre flexion employ biomechan model knee hip estim hip joint reaction forc appli forc generic femur finit element analysi model qualit compar peak princip strain proxim femor neck peak strain model previous studi form exercis result averag peak tensilecompress strain male femal subject respect result vari studi strain achiev nmes general compar achiev walk stair individu match higher intens activ discuss studi demonstr isometr nmes contract thigh muscl creat strain proxim femor neck similar achiev low impact activ nmes alon unlik creat suffici daili strain stimulus prevent bone loss like improv current spaceflight countermeasur ad frequent load throughout day abitant tj bouxsein ml duda kr newman dj potenti neuromuscular electr stimul bone loss countermeasur micrograv aerosp med hum perform
D014893
T070
36,309,789
time cost provid skill pilot studi medic offic occupi time knowledg skill abil level introduct space mission one must consid oper cost medic system crew time medic offic occupi time moot may vari signific depend provid skill pilot studi assess moot skill effect mootsk method expert surgeon es fifth year surgic resid pgi second year surgic resid pgi expert emerg physician ep mo direct surgic train perform two simul appendectomi complet time endotrach intub appendectomi two subprocedur multilay tissu repair singl layer tissu repair record result es perform appendectomi pgi pgi ep averag pgi ep time differ signific compar expert pgi ep time signific longer appendectomi multilay repair either surgic resid singl layer repair ep es differ signific singl intub attempt pgi took ep averag averag record mootsk novic expert sd discuss pilot studi demonstr mootsk captur use simul procedur show magnitud mootsk like substanti suggest high train provid may save substanti crew time limit includ small sampl size limit number procedur simul may reflect real world condit suboptim camera angl levin dr siu kramer k kelli e alouidor r fernandez g kamin time cost provid skill pilot studi medic offic occupi time knowledg skill abil level aerosp med hum perform
D007396;D066231
T065;T097
36,309,787
comparison contribut risk factor primari tooth cari syndrom non special health need children purpos evalu decay miss fill surfac primari teeth dmfs syndrom subject ds compar typic develop td control use analysi method retrospect studi match subject ds td conduct categor variabl evalu associ dental cari mean dmfs main outcom measur pearson chi squar independ sampl test unequ varianc mean employ result overal td control group found signific higher mean dmfs score ds group td equal mean dmfs confid interv ci equal ds equal mean dmfs ci equal p howev control variabl factor african american status p hispan status p incom level percent poverti level p signific differ mean dmfs conclus studi popul ds td exhibit dissimilar dmfs score take consider social econom factor dmfs equival cari risk factor modul diseas experi consid popul specif studi patient multipl high risk factor treat regardless ds status
D003731;D004314
T033;T047
36,309,785
surfac rough prefabr pediatr zirconia crown follow simul toothbrush purpos purpos studi evalu surfac rough three differ brand prefabr pediatr zirconia crown zrcs follow simul toothbrush varieti dentifric method nineti six total maxillari right central incisor prefabr pediatr zrcs n equal zrcsbrand obtain manufactur kinder krown nusmil sprig zrcs equal assign dentifric n equal eightdentifric varieti relat dentin abras rda valu tom main children crest kid previd crest pro health zrcs brush stroke v toothbrush machin use assign dentifric pre post intervent data surfac rough zrcs repres ra averag rough rz mean rough depth obtain use stylus profilomet data analyz independ use two way repeat measur analysi varianc holm sidak method equal result baselin versus brush ra kinder krown previd sprig crest kid indic statist signific differ sprig versus nusmil util crest kid differ chang rough baselin brush nusmil dentifric option differ versus sprig kinder zrcs conclus despit statist signific chang surfac rough small scale although studi address toothbrush differ dentifric may affect mechan properti durabl andor retent properti zrcs studi result provid confid clinician use prefabr pediatr zrcs sustain treatment option along restor option strip crown stainless steel crown
D014099;D003802
T061;T122
36,309,783
recal attend general anesthesia versus oral conscious sedat purpos purpos studi compar recal attend dental rehabilit general anesthesia versus recal attend treatment perform oral conscious sedat method retrospect chart review patient underw general anesthesia oral conscious sedat complet dental treatment januari februari six hundr patient receiv general anesthesia ga receiv oral conscious sedat oc demograph data procedur date recal attend insur reimburs behavior score record result total versus percent ga versus oc group attend period examin within one year restor appoint conclus oral conscious sedat patient attend period examin within one year often general anesthesia patient increas mileag distanc group decreas odd patient would attend period examin
D016292;D000766
T061
36,309,781
fractur resist esthet prefabr custom made crown primari molar artifici age purpos purpos vitro studi compar fractur resist surviv various esthet crown primari molar artifici age via chew simul method typodont tooth mandibular primari second molar prepar receiv five differ type crown follow n equal prefabr fiberglass pf cadcam zirconia cz cadcam resin ceram cr composit strip cs prefabr zirconia pz control specimen subject cycl thermomechan load artifici simul three year clinic servic none crown cs group surviv artifici age surviv crown evalu via micro ct consid microcrack format load fractur test appli data analyz use one way analysi varianc follow duncan test result group pz n cr found compar result p lower group p group cz result highest mean load fractur valu p end three year artifici age microcrack observ cs pf group conclus vitro data suggest test crown except cs crown surviv three year artifici age howev cadcam zirconia crown may provid longer servic show highest fractur resist microcrack format
D019232;D004955
T047;T091;T067
36,309,780
risk factor earli childhood cari three year old japanes children prospect cohort studi purpos purpos studi examin risk factor develop earli childhood cari ecc age three year prospect cohort studi month old children method longitudin observ studi children month age hokkaido japan follow age three year self administ questionnair complet parent guardian children baselin survey content includ sex age exist smoker home matern smoke pregnanc nocturn breastfeed snack habit bottl feed frequenc parent brush child teeth use fluorid toothpast parent share utensil child socio econom status number decay miss fill teeth dmft obtain dental examin baselin follow survey logist regress analysi perform estim odd ratio new onset ecc threeyear old result dmft month old nocturn breastfeed prolong breastfeed snack habit parent brush child teeth less frequent parent share utensil child signific associ incid ecc age three year conclus exist earli childhood cari month old may strong predictor new develop dental cari lifestyl found risk factor incid dental cari age three year
D003731
T033;T047
36,309,779
resin infiltr techniqu molar hypominer treatment preliminari studi pediatr popul purpos purpos studi evalu resin infiltr ri techniqu effect vivo function treatment molar hypominer mh affect perman first molar pfms method fifteen mh affect pfms resin infiltr evalu three month follow fu vivo resin replica use profilometr scan electron microscop sem analysi pfm surfac variat clinic aspect dentin hypersensit regist equal baselin equal right treatment equal oneweek follow equal one two three month fu result mh affect surfac rougher irregular sound one resin infiltr surfac smoother progress increas superfici rough observ time hypersensit improv remain stabl time sever mh case conclus resin infiltr seem promis treatment especi manag sever molar hypominer case evalu follow
D008963
T023
36,309,778
weight blanket use altern protect stabil moder sedat purpos purpos retrospect cross section studi examin protect stabil ps pattern avail weight blanket wbs behavior guidanc approach offic dental moder sedat method retrospect chart review evalu pediatr patient sedat record six pound lead free wbs introduc dental clinic compar clinic outcom time wbs avail multivari logist regress analys assess variabl associ occurr ps use sedat visit result ps ps usag decreas percent percent avail wbs sedat visit chi squar p increas age adjust odd ratio equal percent confid interv ci equal p wb use reduc ps manag adjust equal ci equal p bodi mass index gender treatment amount sedat regimen predict occurr ps number complet teeth treat found statist differ case manag ps versus manag without restraint children manag ps without wbs statist higher heart rate chang treatment children manag without restraint conclus increas age weight blanket use associ reduct occurr protect stabil moder sedat dental visit univers pediatr dental clinic clinic practic sedat protocol consid weight blanket use altern ps
D016292
T061
36,309,777
associ development dental defect clinic consequ primari dentit systemat review observ studi purpos assess whether children development defect enamel dde primari teeth higher risk dental cari higher preval clinic consequ due diseas without dde method search perform pubm scopus web scienc cochran librari lilac bbo embas databas gray literatur three independ review involv studi select data extract bias assess risk bias evalu newcastl ottawa scale dde subtyp demarc opac hypoplasia hypominer second primari molar hspm fluorosi regard exposur dental cari clinic consequ untreat cari also assess meta analys odd ratio use random effect model dichotom outcom qualiti evid assess use grade recommend assess develop evalu grade result search yield studi includ systemat review meta analysi risk bias rang point children dde prone primari tooth cari ci demarc opac ci hypoplasia ci hspm ci fluorosi associ cari ci regard tooth unit analysi dde high associ cari ci clinic consequ cari qualit analysi conduct consensus studi conclus dde associ higher primari tooth cari experi
D003731;D003744;D009050
T033;T047
36,309,776
signific associ taqi foki vdr gene polymorph chronic spontan urticaria colombian caribbean popul chronic spontan urticaria csu inflammatori skin diseas relat poor qualiti life previous studi found vitamin defici vitamin receptor vdr taqi bsmi foki apai gene singl nucleotid polymorph snps influenc immun respons suscept skin disord
D020022;D000080223
T047;T032
36,309,775
preval specif manifest non alcohol fatti liver diseas nafld diabet mellitus type associ moroccan popul cross section studi object non alcohol fatti liver diseas nafld recogn common caus chronic liver diseas worldwid associ type diabet mellitus tdm known increas risk degen complic diabet likelihood develop sever hepat injuri object studi assess preval nafld describ characterist associ tdm method descript analyt studi involv patient tdm histori alcohol consumpt viral hepat hepatotox medic chronic liver diseas patient underw investig nafld includ abdomin ultrasound non invas biomark liver fibrosi elastographi ultrasound guid liver biopsi result collect data patient mean age year strong femal predomin mean durat diabet progress year hepat sonographi show sign nafld case non invas hepat biomark indic signific fibrosi case overal patient underw elastographi evalu reveal sever fibrosi cirrhosi patient diagnosi nash non alcohol steatohepat confirm histolog patient overal preval nafld patient nafld statist signific incid obes metabol syndrom hypertens dyslipidemia macrovascular complic hypertriglyceridemia p conclus combin nafld tdm often found patient obes metabol syndrom presenc nafld respons increas morbid import cardiovascular risk patient tdm
D065626;D003924;D024821
T047
36,309,774
impact covid lockdown incid type dm glycem control diabet children find teach hospit saudi arabia object evalu glycem control among tdm pediatr patient attend endocrinolog pediatr clinic king fahd hospit univers kfhu prior covid restrain regul addit assess trend variat incid tdm includ covid year identifi newli diagnos patient present pediatr emerg depart ed kfhu method estim effect covid incid tdm identifi newli diagnos case tdm among pediatr patient attend ed year particip data collect electron medic record inform collect includ patient age sex hbac read three hbac read interest defin collect pre covid read covid read post covid read result differ femal particip read statist non signific z p pre post covid median q q q q respect contrast differ statist signific among male particip z p pre post covid median q q q q respect statist signific increas hbac person year old z p pre post covid median q q q q respect convers person year old show statist signific chang hbac z p pre post covid median q q q q respect disregard influenc time effect sex show statist signific differ hbac male femal f p meanwhil age effect hbac regardless time influenc statist signific f p statist signific interact time sex hbac level f p age time f p conclus number visit healthcar facil drop signific covid pandem rate newli diagnos tdm increas variabl effect hbac level patient suggest demograph group popul might affect differ pandem futur research determin factor associ better glycem control measur sustain chang pandem might creat
D000086382;D003922
T047;T067
36,309,773
diabet ketoacidosi sever predictor type diabet children year experi teach hospit saudi arabia object object determin trend precipit factor sever diabet ketoacidosi dka popul admit pediatr intens care unit picu larg teach hospit eastern region saudi arabia method conduct retrospect analyt studi king fahad hospit imam abdulrahman bin faisal univers alkhobar saudi arabia retriev complet medic record children admit picu year period children includ polydipsia polyurea abdomin pain vomit dehydr weight loss well breath disturb due acidosi cns issu lethargi coma elev blood glucos level mgdl mmoll venous ph serum total co mmoll blood hydroxybutyr concentr mmoll moder sever ketonuria result picu admiss diagnos dka persist increas rate dka end p incid dka sever dka follow sever moder dka excess sweet intak without ad insulin patient unhealthi lifestyl best predictor sever dka p conclus year period dka pattern persist rise slight fall end signific highest rate urti pneumonia unhealthi lifestyl excess sweet intak signific precipit factor associ sever dka
D016883;D003922
T047
36,309,772
sarcopenia chronic complic type diabet mellitus sarcopenia defin loss skelet muscl mass strength andor decreas physic perform classic relat age howev chronic diseas includ type diabet mellitus tdm may acceler develop sarcopenia previous studi found strong associ tdm sarcopenia insulin resist exist tdm thought key mediat impair physic function mobil may lead sarcopenia tdm may caus sarcopenia mediat insulin resist inflamm accumul advanc glycat end product oxid stress may affect muscl mass strength protein metabol vascular mitochondri dysfunct hand loss muscl sarcopenia may play role develop tdm decreas product myokin play role glucos fat metabol review highlight find exist literatur relationship tdm sarcopenia emphas pathophysiolog chronic vascular complic cours macrovascular microvascular complic tdm
D055948;D003924;D007333
T047;T046
36,309,769
fractur timelin report pattern bisphosphon associ atyp fractur implic postmarket surveil background case report atyp fractur associ bisphosphon first appear literatur larger number report publish object describ report trend bisphosphon associ atyp fractur relat increas awar across medic lay communiti method disproport analys perform assess odd report atyp fractur associ oral bisphosphon use us food drug administr fda advers event report system faer databas report odd ratio ror assess accord prespecifi time period pre awar grow awar post warn result atyp fractur report n bisphosphon associ pre awar period n bisphosphon associ grow awar n bisphosphon associ post warn among report health care profession ror bisphosphon associ atyp fractur across three time period comparison ror among report includ consum increas across three time period highest proport report pre awar period patient year age howev patient year age older compris largest proport report grow awar post warn period discuss report pattern atyp fractur associ bisphosphon therapi appear correl increas awar among medic lay communiti conclus medic expert pharmacist play key role recogn risk factor atyp fractur util fda system support accur event report promot bisphosphon deprescrib clinic appropri
D050071;D050723
T121;T037
36,309,766
geriatr pharmacotherapi case seri neurogen orthostat hypotens case illustr pharmacist role outpati manag neurogen orthostat hypotens noh communiti dwell older person case patient long stand histori asymptomat hypotens recent onset fall temporari loss conscious prompt initi pharmacolog therapi case review nonpharmacolog pharmacolog treatment option older peopl symptomat noh
D007024
T047
36,309,764
assess impact consult pharmacist pneumococc vaccin administr long term care facil object describ impact consult pharmacist recommend frequenc pneumococc vaccin administ older peopl admit long term care facil ltcf design retrospect observ studi set ltcf skill intermedi level care particip adult patient newli admit ltcf southwestern pennsylvania decemb novemb januari decemb includ intervent intervent studi consult pharmacist driven immun screen servic implement part admiss medic review process januari assess impact servic pneumococc immun rate patient candid pneumococc vaccin compar two patient cohort defin exposur immun need assess subsequ recommend consult pharmacist result total patient admiss includ cohort cohort pneumococc immun rate calcul number pneumococc vaccin administ number admiss elig pneumococc vaccin statist signific increas p conclus recommend consult pharmacist result immun need assess upon admiss ltcf signific contribut increas rate pneumococc immun investig warrant evalu futur strategi reduc vaccin refus
D022242;D010595
T129;T121;T097
36,309,762
predict modul neural respons eye contact asd deficit establish maintain eye contact earli persist vulner autism spectrum disord asd neural base deficit remain elus promis hypothesi social featur autism may reflect difficulti make predict social world condit uncertainti howev research asd examin predict impact neural process eye contact naturalist interperson interact
D000067877;D001321
T048
36,309,760
enter versus parent nutrit pancreaticoduodenectomi enhanc recoveri surgeri protocol studi protocol multicent open label random control trial ene pan trial infecti complic main caus morbid pancreaticoduodenectomi pd earli enter nutrit en reason form nutrit support aim mitig occurr sever infecti complic maintain gut immun howev remain unclear whether en benefici patient underw pd enhanc recoveri surgeri era protocol
D016577;D000080482
T061
36,309,759
treatment nonarterit anterior ischem optic neuropathi endothelin antagonist endothelion endothelin antagonist receptor ischem optic neuropathi multicentr randomis control trial protocol nonarterit anterior ischem optic neuropathi naaion major caus blind individu year age avail effect treatment oral dual endothelin receptor antagonist bosentan increas retin optic nerv head blood flow healthi human glaucoma patient object trial assess efficaci bosentan administ acut stage improv outcom naaion patient
D018917
T047
36,309,757
assess causal relationship gout hypertens bidirect mendelian randomis studi coarsen exposur observ studi demonstr associ gout hypertens whether causal remain unclear work aim assess causal relationship gout hypertens
D006073;D006973
T047
36,309,756
evalu cultur compet south african cluster randomis control trial lesson learn trial report standard failur consid relev cultur ethnic divers paramet intersect paramet trial protocol develop trial conduct may negat impact recruit intervent develop deliveri particip adher retent potenti reduc overal intern valid case studi aim evalu util compar item gibb framework measur cultur compet gripp short form sf point checklist assess patient public involv context complex clinic trial conduct african set
D054521;D057189
T078;T170;T054
36,309,755
role plasminogen activ inhibitor pneumococc mening pneumococc mening associ dysregul coagul cascad previous detect upregul cerebr plasminogen activ inhibitor pai mrna express pneumococc mening divers function ascrib pai role remain unclear analyz function serpinb code pai patient bacteri mening well establish pneumococc mening mous model use serpinb knockout mice vitro wt pai defici bone marrow deriv macrophag bmdms measur pai cerebrospin fluid patient perform function histopatholog protein mrna express analys vivo vitro found substanti increas pai concentr csf patient pneumococc mening regul increas releas pai mice pai defici associ increas mortal murin pneumococc mening cerebr hemorrhag serpinb mice exhibit increas ca level decreas il level brain pneumococc infect vitro experi confirm increas express releas pai wt bmdm decreas il liber pai defici bmdm upon pneumococc challeng data show pai elev pneumococc mening human mice pai defici caus inflammatori imbal result increas brain patholog mortal
D008586
T047;T050
36,309,754
adenosquam carcinoma pancrea two case report review literatur among total report case pancreat duct adenocarcinoma around adenosquam carcinoma pancrea due limit data preoper diagnosi great challeng physician usual set post oper base pathologist report oper two case adenosquam carcinoma pancrea present alongsid oper treatment plan
D018196;D010190
T191
36,309,753
montelukast reduc grey matter abnorm function deficit mous model inflamm induc encephalopathi prematur encephalopathi prematur eop affect approxim infant born week gestat high associ inflamm foetus evalu efficaci montelukast cysteinyl leukotrien receptor antagonist wide use treat asthma children amelior peripher central inflamm subsequ grey matter neuropatholog behaviour deficit mous model eop male cd mice treat intraperiton ip salin interleukin beta il gkg lg bodi weight postnat day p concomit montelukast mgkg salin montelukast treatment continu day post injuri assess system central inflamm short term neuropatholog perform h follow treatment p behaviour test mri neuropatholog assess made second cohort anim p montelukast found attenu peripher central inflamm reduc express pro inflammatori molecul il il tnf brain inflamm induc reduct parvalbumin posit interneuron densiti cortex normalis high dose montelukast lowest effect dose mgkg abl improv anxieti spatial learn deficit model inflammatori injuri alter cortic mean diffus present anim receiv dose montelukast repurpos montelukast administ earli preterm birth may therefor improv grey matter develop outcom eop
D047928;D011804;D001927
T047;T046;T109
36,309,751
evalu factor influenc length hospit stay use data mine techniqu length stay los time hospit admiss discharg los impact hospit manag hospit care function
D010351;D006760
T058
36,309,750
score model base signatur non relat neoantigen code lncrnas assist immun microenviron analysi tcr neoantigen pair select glioma small peptid encod long non code rnas lncrnas attract attent various function recent studi indic small peptid particip immun respons antigen present howev signific rna modif remain unclear
D062085;D005910
T123;T191;T114
36,309,749
research protocol impact assess project scale food polici pacif one challeng countri implement food polici measur difficulti demonstr impact retain stakehold support consequ research fund help countri overcom challeng assess impact translat practic particular low resourc set howev still attempt prospect comprehens assess research impact protocol describ studi co creat project implement collabor investig key stakehold optim monitor impact research project scale food polici fiji
D057170;D012107
T062;T096;T170;T081;T169
36,309,748
circul anti mllerian hormon cohort studi women sever obes without polycyst ovari syndrom effect one year weight loss intervent women polycyst ovari syndrom pcos high circul anti mllerian hormon amh level correl antral follicl count polycyst ovarian morpholog negat correl bodi mass index bmi moreov diet induc weight loss women pcos overweight obes reduc normal amh level howev previous studi investig circul amh level women sever obes structur diet induc weight loss program affect circul amh level women therefor studi aim investig circul amh level popul women sever obes bmi kgm without pcos diagnos nih criteria investig effect one year weight loss program low energi diet vled circul level amh
D009767;D011085
T047
36,309,747
causal relationship obes lifestyl factor risk benign prostat hyperplasia univari multivari mendelian random studi obes waist circumfer bodi mass index bmi lifestyl factor dietari habit smoke alcohol drink sedentari behavior associ risk benign prostat hyperplasia bph observ studi whether associ causal unclear
D057182;D011470
T062;T047;T191
36,309,746
updat consolid framework implement research base user feedback mani implement effort fail even high develop plan execut contextu factor power forc work implement real world consolid framework implement research cfir one common use determin framework assess contextu factor howev year sinc public need updat purpos project elicit feedback experienc cfir user inform updat framework
D003695;D000077626
T090;T058;T093
36,309,745
hospit base prostat cancer screen vietnames men lower urinari tract symptom classif regress tree model prostat cancer pca common diseas men year age detect earli reduc unnecessari biopsi studi aim construct classif regress tree cart model ie risk stratif algorithm use multivari approach select vietnames men lower urinari tract symptom lut pca biopsi
D011471;D059411
T184;T191
36,309,744
electron pillbox intervent design improv medic safeti care transit challeng lesson learn regard implement evalu advers drug event common transit care part smart pillbox studi cluster random control trial electron pillbox design reduc medic discrep improv medic adher hospit discharg explor barrier success implement evalu intervent
D010360;D010595
T058;T097
36,309,743
cosmesi feasibl transvagin natur orific specimen extract nose larg organ specimen prospect pilot studi studi aim evalu cosmet outcom feasibl transvagin natur orific specimen extract nose patient underw laparoscop robot surgeri treatment benign malign diseas kidney liver stomach adren gland bladder
D010535;D057605
T060;T061
36,309,742
diabet mellitus durat mortal patient hospit acut myocardi infarct diabet mellitus dm associ increas mortal risk patient hospit acut myocardi infarct ami howev studi investig impact durat dm hospit mortal studi evalu hospit mortal ami patient accord dm status durat
D000072657;D000072658;D009203;D003920
T047
36,309,741
end life care idiopath pulmonari fibrosi patient acut exacerb acut exacerb ae major caus death patient idiopath pulmonari fibrosi ipf ae ipf patient requir optim palliat care howev real world clinic situat poor understood aim survey palliat care receiv ae ipf patient especi respect opioid use dyspnea end life discuss eold
D054990;D013727
T047;T058
36,309,740
med mutat potenti predict biomark immun checkpoint inhibitor pan cancer immun checkpoint inhibitor ici therapi elicit admir anti tumor respons across mani type cancer grow evid point link mediat complex subunit med dna damag repair ddr tgf sign clinic data associ med ici respons lack studi clinic whole exom sequenc wes data publish studi merg wes cohort explor associ med mutat med mut ici effici across cancer memori sloan ketter cancer center mskcc cohort use valid find cancer genom atlas tcga cohort use perform anti tumor immun prognosi analysi wes cohort n signific differ detect med mut med wildtyp med wt patient regard durabl clinic benefit dcb vs p addit signific prolong pfs observ med mut patient mpfs reach nr vs month hr ci log rank p take account age gender metastasi treatment tmb status result multivari cox proport hazard regress show signific better pfs hr ci p mskcc cohort n overal surviv advantag achiev med mut patient mos vs month hr ci log rank p take account factor wes cohort link still exist hr ci p notabl tmb also found signific higher med mut patient wes mskcc cohort tumor infiltr lymphocyt ddr relat gene analysi reveal anti tumor immun med mut patient total med mut success predict better clinic outcom ici treat pan cancer cohort indic med mut could serv potenti predict biomark immun checkpoint inhibitor pan cancer
D000082082;D009369
T129;T121;T191;T043
36,309,738
comparison short term effect lumbar endoscop microscop tubular unilater laminotomi bilater decompress treatment elder patient lumbar spinal stenosi compar clinic efficaci lumbar endoscop delta larg channel microscop tubular quadrant channel unilater laminotomi bilater decompress treatment elder patient lumbar spinal stenosi
D013130
T020
36,309,735
synapt proteom reveal distinct molecular signatur cognit chang corf repeat expans human al cortex increas evid suggest synapt dysfunct central possibl trigger factor amyotroph later sclerosi al despit still know littl molecular profil al synaps address gap design synapt proteom experi perform unbias assess synapt proteom al brain isol synaptoneurosom fresh frozen post mortem human cortex control al stratifi al group base cognit profil edinburgh cognit behaviour al screen eca score presenc corf hexanucleotid repeat expans corf allow us assess region differ impact phenotyp genotyp synapt proteom use tandem mass tag base proteom identifi protein synaptoneurosom use robust bioinformat analysi valid strong enrich synaps found al associ protein synaptoneurosom includ tdp fus sod corf identifi almost protein alter express level al region specif chang highlight protein pathway intrigu link neurophysiolog patholog stratifi al cohort cognit status reveal almost specif alter cognit impair al synapt prepar stratifi corf status reveal protein alter corf group kegg pathway analysi highlight strong enrich postsynapt dysfunct relat glutamaterg receptor signal valid chang western blot singl synaps level use array tomographi imag summari generat first unbias map human al synapt proteom reveal novel insight key compart al pathophysiolog highlight influenc cognit declin corf synapt composit
D000690;D057180
T047;T048
36,309,733
bile pigment emerg critic care medicin bile pigment bilirubin biliverdin end product heme degrad pathway mammal wide known cytotox effect howev recent studi reveal exert cytoprotect effect antioxid anti inflammatori immunosuppress properti mechan indispens treatment diseas field emerg critic care medicin coronari ischemia stroke encephalomyel acut lung injuryacut respiratori distress syndrom mesenter ischemia sepsi research requir safe applic bile pigment clinic set under mechan shed light util therapeut agent field emerg critic care medicin articl aim summar current understand bile pigment evalu therapeut potenti diseas list
D001654;D012128
T123;T047;T109
36,309,732
patient satisfact e oral health care rural remot set systemat review past decad e oral health technolog use address oral health care challeng rural remot set review systemat evalu literatur patient satisfact e oral health care rural remot communiti
D017060;D009909
T033;T080
36,309,731
silenc el suppress progress colorect cancer via target depdc colorect cancer crc one common diagnos human malign ribosom protein l rpl aka el compon larg ribosom subunit express pattern function role crc report
D015972;D015179
T045;T191
36,309,730
high throughput screen assay identifi inhibitori antibodi target alphavirus releas sever studi demonstr neutral antibodi high effect alphavirus infect anim model prophylact remedi studi neutral antibodi evalu abil block viral entri vitro recent evid suggest antibodi inhibit mechan includ viral buddingreleas signific contribut viral control vivo number alphavirus
D000524;D002646;D018354;D065632
T005;T047
36,309,729
coexist chronic hyperalgesia multilevel neuroinflammatori respons experiment sci systemat approach profil neuropath pain peopl spinal cord injuri sci frequent develop neuropath pain np worsen disabl diminish rehabilit efficaci chronic np present incur due poor understand under mechan hypothes multilocus neuroinflamm nif might driver sci np test investig whether np coexist central nif neurotransmiss ntm neuromodul nml neuroplast npl chang post sci
D009437;D013119
T184;T047;T037
36,309,728
predictor morbid revision bariatr surgeri bariatr emerg mbsaqip accredit communiti hospit bariatr surgeri revis emerg associ higher morbid mortal compar primari bariatr surgeri formal outcom benchmark exist distinguish mbsaqip accredit center communiti unaccredit institut
D009767;D050110
T061;T047
36,309,727
mechanist insight health benefit fish oil supplement fine particul matter air pollut random control trial dietari fish oil supplement might attenu associ fine particul matter pm subclin biomark howev molecular mechan remain elucid studi aim explor molecular mechan fish oil supplement pm induc health effect
D005395;D000397
T121;T127;T080;T109;T069
36,309,726
fluoroscop view midshaft clavicular fractur reduct intern fixat posteroanterior skylin project open reduct intern fixat frequent appli displac midshaft clavicular fractur plate screw fixat clavicular fractur could provid rigid fixat rotat control proper implant posit surgic fixat critic prevent iatrogen complic fluoroscopi play import role intraop evalu implant studi aim introduc new fluoroscop project evalu posit plate screw
D002968;D050723
T023;T037
36,309,725
methodolog qualiti systemat review treatment alzheim diseas cross section studi care conduct systemat review srs provid reliabl evid effect treatment strategi alzheim diseas ad nevertheless reliabl sr result limit methodolog flaw cross section studi aim examin methodolog qualiti srs ad treatment along potenti relev factor
D000544
T047;T048
36,309,724
prognost valu coronari microvascular dysfunct assess coronari angiographi deriv index microcirculatori resist diabet patient chronic coronari syndrom coronari microvascular dysfunct cmd common associ unfavor cardiovascular event patient diabet mellitus dm coronari angiographi deriv index microcirculatori resist caimr recent develop wire hyperem agent free method assess cmd aim investig prognost impact cmd assess caimr clinic outcom patient dm chronic coronari syndrom ccs
D003920;D003324;D017202
T047
36,309,723
altern career pathway decis support job databas intern medic graduat canada canadian regul made challeng intern medic graduat img get job origin profess physician consequ altern career gain interest among img avoid underemploy unemploy conduct research identifi factor img consid take altern career canada base understand aim creat databas inform health relat altern job present searchabl way aid img strateg job search
D005550;D010820
T097
36,309,722
hospit manag view state patient safeti cultur across three region ghana improv patient safeti cultur healthcar organis contribut posit qualiti care patient attitud toward care hospit manag undoubt play critic role creat patient safeti cultur ghana qualit studi focuss hospit manag view state patient safeti cultur hospit remain scanti
D061214;D017751
T058;T080;T057
36,309,721
novel protein repel antibacteri polymethyl methacryl dental resin water age month present studi aim develop novel protein repel antibacteri polymethyl methacryl pmma dental resin methacryloyloxyethyl phosphorylcholin mpc quaternari ammonium dimethylaminohexadecyl methacryl dmahdm investig effect water age month mechan properti protein adsorpt antibacteri activ dental resin
D019904;D014867
T121;T122;T197;T109
36,309,719
ownership individu level health data data share data govern ownership status individu level health data affect manner use paper analyz two compet model ownership status data discuss literatur recent privat ownership public ownership
D010067;D033181
T078;T081;T052;T054
36,309,718
cluster behet syndrom cluster import clinic featur behet syndrom bs may pathogenet therapeut implic recent previous studi bs phenotyp differ substanti term methodolog correl matric factor analys effici enough uncov cluster cluster pattern may chang accord demograph factor age sex cluster pattern may also profound influenc mispercept symptom assum secondari bs fact repres manifest bd mimic give rise mislead conclus kept mind interpret data obtain cluster phenotyp analys bs true geographicalraci variabl diseas express could studi multin consensus cohort pathogenet studi separ cluster bs still lack
D001528
T047
36,309,717
ent characterist therapeut result multisystem disord mitochondri encephalomyopathi report evalu frequenc subject object otolaryngolog find therapeut result patient mitochondri encephalomyopathi mem septemb june analysi includ studi patient famili histori clinic manifest mem therapeut effect treatment patient age rang year median age year found mem ent symptom character hear loss dysphagia facial weak case sensorineur hear loss bilater symmetr progress sudden deaf sinc adolesc often underestim associ neuromuscular symptom requir mtdna test dysphagia facial weak occur preferenti middl age patient muscl biopsi advis distort product otoacoust emiss auditori brainstem responsetest sensit reliabl pure tone averag object monitor pathogenesi administr mitochondri synthas complex benefit patient acut episod patient fulli recov exhibitedresidu languag deficit hear aid cochlear implant recommend counsel given regard synthet treatment facial weak endoscop circopharyngealmyotomi dysphagia surgic correct ptosi studi demonstr increas awar symptom import address appropri intervent avoid complic ablepsia aphasia social isol malnutrit aspir pneumonia heart failur set mem
D017237;D003680;D006319
T047
36,309,716
comprehens bibliometr visual analysi research fecal microbi transplant publish fecal microbi transplant emerg recent year method treat diseas rebuild intestin flora howev bibliometr analys systemat studi area research aim use bibliometr analysi visual trend topic research fecal microbi transplant help provid insight futur trend clinic basic research
D035843
T062
36,309,714
long term cardiovascular outcom gestat diabet mellitus prospect uk biobank studi previous studi show gestat diabet mellitus gdm risk factor subsequ atherosclerot cardiovascular diseas howev pauciti inform regard divers cardiovascular outcom elder women gdm current studi examin whether women histori gdm increas risk long term overal cardiovascular outcom
D016640;D006973;D050171;D002318
T047;T046
36,309,712
optim exosom product strategi enhanc yield without sacrif cargo load effici exosom mediat mrna deliveri promis strategi treatment multipl diseas howev low yield exosom bottleneck clinic translat studi boost exosom product via simultan reduc express gene inhibit exosom biogenesi supplement cultur medium red cell membran compon
D055354
T026
36,309,708
influenc covid pandem decis make patient undergo gamma knife radiosurgeri gamma knife radiosurgeri gk common use approach treatment intracrani lesion radiat respons typic immedi delay studi analyz case prospect collect databas assess influenc covid pandem decis make patient treat gamma knife radiosurgeri
D016634;D000086382;D001932
T061;T047;T191;T067
36,309,707
health relat qualiti life among postpartum women preeclampsia southern ethiopia prospect cohort studi preeclampsia affect health mother fetus pregnanc childbirth date littl known impact preeclampsia postpartum health relat qualiti life hrqol sidama region southern ethiopia studi aim measur hrqol contribut factor among postpartum women preeclampsia sidama region
D011225;D066087;D047928
T033;T046
36,309,704
olfactori marker protein unlik cleav calpain olfactori matur marker protein omp express olfactori receptor neuron hypothalam neuron omp nest gene locat intron calpain capn ca depend cystein proteas despit locat genom locus genet regul reciproc express omp capn suggest perform motif search detect possibl calpain cleavag site omp howev direct proteolyt regul omp capn unclear generat omp fuse myc tag tag n c termini examin whether capn cleav omp fragment detect immunoreact myc omp western blot demonstr omp unlik cleav even presenc ca vitro express omp capn hekt cell appli calcium ionophor physiolog condit cellulo result appar fragment omp also appli liquid chromatographymass spectrometri electrophores fraction smaller uncut myc omp signal demonstr signific fragment omp result collect indic omp unlik cleav capn
D002154;D018034
T026;T123;T116;T025;T126
36,309,703
combin albumin globulin ratio plasma fibrinogen sensit tool preoper screen infect nonunion patient undergo reoper open reduct intern fixat retrospect studi accur preoper diagnosi infect nonunion remain challeng evalu diagnost potenti novel biomark infect nonunion
D005340;D002097
T129;T123;T121;T116
36,309,702
big data cardiac surgeri real world perspect big data deriv analysi techniqu artifici intellig machin learn consid revolut modern practic medicin big data come multipl sourc encompass electron health record clinic studi imag data registri administr databas patient report outcom omic profil main object analys unveil hidden associ pattern cardiac surgeri main target use big data construct predict model recogn pattern associ better repres individu risk prognosi compar classic surgic risk score result studi contribut kindl interest person medicin contribut recogn limit random control trial repres real world howev main sourc evid guidelin recommend remain rcts meta analysi extent revolut big data new analyt model cardiac surgeri yet determin
D000077558;D006348
T061;T170
36,309,701
independ intern food inform council food beverag industri content analysi intern industri document intern food inform council ific partner foundat ific foundat wide dissemin nutrit inform particip relev policymak process prior research establish connect ific larg food beverag compani repres potenti conflict interest author review public record document investig connect ific industri describ ific communic polici relev inform nutrit scienc public
D011050;D003132
T078;T097;T081;T064;T057
36,309,700
patient report outcom phosphomannomutas congenit disord glycosyl pmm cdg listen matter patient health profession congenit disord glycosyl cdg grow group rare genet disord common cdg phosphomannomutas pmm cdg often sever clinic present life limit consequ approv therapi condit also valid diseas specif qualiti life qol scale assess heterogen clinic burden pmm cdg present challeng assess diseas sever impact certain treatment cours diseas
D018981;D017875
T047;T126;T116
36,309,699
express long noncod rnas ovarian granulosa cell women diminish ovarian reserv use high throughput sequenc infertil global reproduct health problem diminish ovarian reserv dor one common caus femal infertil long noncod rnas lncrnas crucial regul numer physiolog patholog process human howev whether lncrnas involv develop dor remain elucid
D062085;D007247;D065851;D010049;D026921
T123;T116;T042;T033;T114;T047;T046
36,309,698
prognost clinicopatholog signific cd express cancer patient meta analysi previous report cd often express varieti cancer type fact known involv cancer develop role cancer wide establish howev clinic mechanist studi involv cd yield conflict result thus present studi aim evalu overal prognost valu cd cancer patient use comprehens analysi
D001943;D004067
T191
36,309,697
associ singl nucleotid polymorph rs relat ndufv lumbar disc degener pilot case control studi associ singl nucleotid polymorph snps rs rs rs rs rs rs relat gene name nadh dehydrogenas ubiquinon flavoprotein ndufv lumbar disc degener ldd preliminari investig small sampl size
D055959;D017116
T184;T047;T190
36,309,696
pitfal method studi coloc nanoparticl mous macrophag lysosom field nanosci increas interest follow dynam nanoparticl np cell emphasi endo lysosom pathway long term np fate research topic encount sever pitfal bias experiment outcom address pitfal suggest possibl solut accuraci fluoresc microscopi method import role obtain insight np interact lysosom singl cell level includ quantif np uptak specif cell type
D008247;D053758
T026;T073
36,309,695
clinic radiolog outcom modifi phemist procedur coracoclavicular ligament augment use mersilen tape versus hook plate fixat acut acromioclavicular joint disloc clinic superior surgic treatment acromioclavicular ac joint disloc remain controversi aim studi compar clinic radiolog outcom modifi phemist procedur cc ligament augment use mersilen tape hook plate fixat acut ac joint disloc
D000173;D010014;D004204
T023;T046;T037;T030
36,309,694
immun relat lncrna prognost signatur predict immun landscap prognosi bladder cancer n methyladenosin relat long noncod rnas lncrnas may prognost valu bladder cancer key role tumorigenesi innat immun
D062085;D001749
T123;T191;T114
36,309,692
hush mediat hiv silenc independ tasor phosphoryl threonin tasor compon hush repressor epigenet complex samhd cellular triphosphohydrolas dntpase anti hiv protein antagon hiv sivsmm viral protein x result viral protein abl reliev two differ block along viral life cell cycl one level revers transcript degrad samhd one level provir express degrad tasor phosphoryl samhd shown downregul antivir activ discoveri tasor lie within samhd like motif led us ask whether tasor phosphoryl residu whether post translat modif could regul repress activ
D015497;D015658;D020559
T005;T126;T116;T047
36,309,691
prepar novel monoclon antibodi activ compon pha l phaseolus vulgari function characterist leukocyt phytohemagglutinin pha l deriv l tetram pha frequent employ mitogen induc lymphocyt prolifer vitro biolog applic pha l cancer diagnosi treatment gain traction recent year howev note pha l obtain use tradit procedur massiv amount impur toxic compon interfer activ pha l prepar monoclon antibodi activ pha l signific tool studi pha l function therapeut potenti
D000911;D027805
T129;T168;T116;T002
36,309,690
effect target resist intervent compar sham intervent gluteal muscl hypertrophi fatti infiltr strength peopl hip osteoarthr analysi secondari outcom randomis clinic trial peopl hip osteoarthr typic offer combin educ exercis address muscl atrophi weak limit evid exist assess efficaci exercis program muscl structur function popul aim studi evalu effect target resist exercis gluteal muscl hypertrophi strength peopl mild moder hip osteoarthr
D015207
T047
36,309,689
postur habit lifestyl factor associ adolesc idiopath scoliosi ai china result big case control studi adolesc idiopath scoliosi ai preval type scoliosi affect children age year howev risk factor ai particular modifi one still larg unknown studi aim investig associ lifestyl social environ factor ai chines schoolchildren
D012600;D007738
T047;T190
36,309,688
nanoparticl mediat select sfrp silenc enhanc bone densiti osteoporot mice osteoporosi op character loss bone mass miner densiti stimul canon wnt catenin pathway report promot bone format pathway control sever regul secret frizzl relat protein sfrp antagonist pathway thus sfrp silenc therapi could suitabl enhanc bone growth howev system stimul wnt catenin correl side effect work hypothes administr lipid polym nps lpnps function msc specif aptam apt carri sfrp silenc gapmer could favor bone format op minim undesir effect suitabl sfrp gapmer load apt lpnps apt lpnps sfrp administ osteoporot mice biodistribut toxic bone induct capac evalu aptam function nps modifi biodistribut profil show four fold increas bone accumul ten fold decreas hepat accumul compar nake lpnps moreov histolog evalu reveal evid chang bone structur observ compact trabecular bone cortic bone thick increas apt lpnps sfrp treat mice toxic effect therefor lpnps show suitabl properti biodistribut profil lead enhanc bone densiti osteoporot mice
D051176;D053758
T123;T116;T073
36,309,686
framework clinic util robot exoskeleton rehabilit exoskeleton extern worn motor devic assist sit stand walk individu motor function impair food drug administr fda approv sever technolog clinic use howev limit evid guid optim util everi day clinic practic divers technolog equip avail present challeng clinician decid devic use initi implement technolog differ patient present wean devic thus present clinic util framework specif exoskeleton four aimsthes aim assist clinic decis make exoskeleton use clinic indic identif devic appropri base patient deficit devic characterist provid guidanc dosag paramet within plan care guidanc reflect follow util framework streamlin clinician approach implement synthesi publish evid appropri clinic assess devic select reflect success understand innov complex technolog
D000067190
T074
36,309,684
preferenti subcort collater project pedunculopontin nucleus target cortic pyramid neuron reveal brain wide singl fiber trace pedunculopontin nucleus ppn heterogen midbrain structur involv various brain function motor control learn reward sleep previous studi use convent tracer shown ppn receiv extens affer input various cortic area examin cortic axon make collater project subcort area use dual viral inject strategi spars label ppn target cortic pyramid neuron camkii cre transgen mice use high speed volumetr imag fli scan readout visor techniqu visual brain wide axon project individu ppn target neuron sever cortic area includ prelimb region pl anterior cingul area aca secondari motor cortex mos found ppn project neuron uniqu profil collater subcort area preferenti target particular ppn project neuron three trace cortic area exhibit common preferenti collater sever nuclei neuron target striatum str later hypothalam area lha periaqueduct gray pag substanti portion neuron also target zona incerta zi median raph nucleus mrn substantia nigra par reticulata snr meanwhil specif collater pattern found nuclei includ intermedi reticular nucleus irn parvicellular reticular nucleus parn gigantocellular reticular nucleus grn receiv collater input almost exclus mos observ provid potenti anatom mechan cortic neuron coordin ppn subcort area perform differ physiolog function
D001921;D009044
T023;T029
36,309,682
primari immatur teratoma liver grow teratoma syndrom gliomatosi peritonei rare case report primari liver immatur teratoma extrem rare case report let alon grow teratoma syndrom gts andor gliomatosi peritonei gp
D010051;D013724
T191