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biomedical-topic-categorization-validation

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36.4M
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36,309,515
flexibl hyperspectr surfac plasmon reson microscopi optic techniqu visual quantif chemic biolog analyt alway high desir show hyperspectr surfac plasmon reson microscopi hsprm system use hyperspectr microscop analyz select area spr imag produc prism base spectral spr sensor hsprm system enabl monochromat polychromat spr imag singl pixel spectral spr sens well two dimension quantif thin film measur reson wavelength imag perform pixel pixel calibr incid angl remov pixel pixel differ spr sensit demonstr hsprm capabl use quantifi monolay graphen thick distribut inhomogen protein adsorpt singl cell adhes hsprm system wide spectral rang nm nm option field view mm mm high later resolut demonstr innov breakthrough spr sensor technolog
D020349;D006108
T063;T196;T109
36,309,514
administr broad neutral anti hiv antibodi art initi maintain long term cd cell immun simian human immunodefici virus shiv infect non human primat broad neutral antibodi bnab virus appear stimul cell immun determin whether phenomenon also occur human measur hiv specif cellular immun longitudin individu hiv start antivir therapi art without adjunct bnab bnc treatment use activ induc marker aim assay interferon releas observ frequenc pol gag specif cd cell well gag induc interferon respons signific higher among individu receiv adjunct bnc compar art alon month start art observ chang cellular immun direct correl pre treatment bnc sensit notabl increas hiv specif immun associ partial complet art free virolog control treatment interrupt year find suggest bnab treatment time art initi maintain hiv specif cd cell respons associ art free virolog control
D016097;D015302;D015497;D015658
T047;T005
36,309,512
natur scene sampl reveal reliabl coars scale orient tune human v orient select primat visual cortex organ cortic column sinc cortic column finer spatial scale sampl resolut standard bold fmri measur analysi approach propos peer past spatial resolut limit recent found method predomin sensit stimulus vignet form select aris interact orient stimulus apertur edg beyond vignet clear whether orient select neural respons detect bold measur leverag dataset visual cortic respons measur use high field fmri fit respons use imag comput model compens vignet nonetheless find reliabl tune orient result reveal coars scale map orient prefer may constitut neural basi known perceptu anisotropi find settl long stand debat human neurosci provid insight function organ principl visual cortex
D001931;D014793
T062;T060;T029;T023
36,309,511
biomimet lamin strategi enabl strain interfer free durabl flexibl thermistor electron develop flexibl thermistor epiderm electron ftee satisfi high temperatur resolut without strain induc signal distort great signific still challeng inspir nacr microstructur capabl restrain stress concentr exemplifi versatil mxene base thermistor elastom sensor tes platform signific allevi strain interfer biomimet lamin strategi combin plane stress dissip nacr mimet hierarch architectur deliv competit advantag superior thermosensit c outstand temperatur resolut c unparallel mechan durabl fold fatigu cycl togeth consider improv strain toler thermosens commerci thermocoupl exercis scenario combin theoret model simul microstructur observ superpos signal detect author reveal under temperatur strain signal decoupl mechan substanti general customiz nacr mimet strategi possess insight signific fabric ftee static dynam temperatur detect
D060734
T109
36,309,510
cellular glycan modif bgat broad restrict influenza virus infect communic respiratori viral infect pose epidem pandem threat broad spectrum antivir strategi could improv prepared event discov host antivir restrict factor may act suitabl target develop host direct antivir therapi conduct whole genom crispr activ screen influenza b virus ibv top hit screen beta glucuronyltransferas bgat effect block ibv infect subsequ studi reveal bgat activ prevent cell surfac sialic acid express due mechan action bgat express broad restrict infect virus requir sialic acid entri includ victoria yamagata lineag ibv hnhn influenza virus iav unrel enterovirus understand potenti util bgat induct antivir strategi vivo specif express bgat murin respiratori epithelium find overexpress well toler also protect femal mice lethal viral challeng multipl influenza virus includ pandem like hn iav thus bgat may repres host direct broad spectrum antivir target util clinic relev respiratori virus
D007251;D053118;D009976
T047;T005
36,309,507
trace intern arriv sar cov omicron variant aotearoa new zealand reopen border second quarter global surg emerg sar cov lineag distinct growth advantag domin omicron ba ba lineag generat omicron genom show aotearoa new zealand observ influx immun evas variant ba ba ba border explain return signific level intern travel follow border reopen march estim one omicron transmiss event border communiti everi passeng arriv current level travel restrict although introduct instig detect onward transmiss small minor trigger larg outbreak genom surveil border provid len rate new variant might gain foothold trigger new wave infect
D000086402;D000086382
T005;T067;T047
36,309,506
proteo genom character virus associ liver cancer reveal potenti subtyp therapeut target primari liver cancer heterogen diseas term etiolog histolog therapeut respons concurr proteom genom character larg set clinic liver cancer sampl help elucid molecular basi heterogen thus serv valuabl resourc person liver cancer treatment studi perform proteom profil protein primari liver cancer tissu revers phase protein array mutat analysi use whole genom sequenc transcript analysi rna seq patient japanes ethnic background main hbv hcv posit provid insight import liver cancer subtyp unsupervis classif tumor base protein express profil reveal three proteom subclass r r r r subclass immunolog hot demonstr good prognosi r contain advanc prolif tumor tp mutat high express vegf receptor worst prognosi r enrich ctnnb mutat elev mtor signal pathway activ twenti two protein includ cdk cdkna identifi potenti prognost marker proteom classif present studi help guid therapeut decis make liver cancer treatment
D040901;D008113
T191;T091
36,309,502
autom identif sequenc tailor cas protein use massiv metagenom data identif protospac adjac motif pam sequenc cas nucleas crucial exploit genom edit develop comput pipelin use interrog massiv expand dataset metagenom virom assembl accur comprehens pam predict procedur allow identif isol sequenc tailor cas nucleas use target sequenc bait proof concept start diseas caus mutat ph rho gene find isol experiment valid cas use mutat sequenc pam pam predict pipelin instrument generat cas nucleas repertoir respond pam requir
D000076987;D064113
T040;T126;T116
36,309,500
multipl sourc aerob methan product aquat ecosystem includ bacteri photosynthesi aquat ecosystem global signific sourc greenhous gas methan atmospher recent methan product thought strict anaerob process confin primarili anox sediment howev supersatur methan oxygen water consist observ lake ocean term methan paradox indic methan produc oxic condit unclear mechan show aerob methan product multipl sourc freshwat incub experi differ treatment base biogeochem metagenom metatranscriptom data find aerob methan product appear associ bacterio chlorophyl metabol photosynthesi well proteobacteri degrad methylphosphon gene encod pathway putat photosynthet methylphosphon base methan product also co occur proteobacteri metagenom assembl genom find provid insight known mechan aerob methan product suggest potenti co occur mechan associ bacteri photosynthesi aquat ecosystem
D017753;D060106
T083;T070;T082
36,309,499
isotrop reconstruct electron tomographi deep learn cryogen electron tomographi cryoet allow visual cellular structur situ howev anisotrop resolut aris intrins miss wedg problem present major challeng visual interpret tomogram develop isonet deep learn base softwar packag iter reconstruct miss wedg inform increas signal nois ratio use knowledg learn raw tomogram without need sub tomogram averag isonet generat tomogram signific reduc resolut anisotropi applic isonet three repres type cryoet data demonstr great improv structur interpret resolv lattic defect immatur hiv particl establish architectur paraflagellar rod eukaryot flagella identifi heptagon contain clathrin cage insid neuron synaps cultur cell therefor overcom two fundament limit cryoet isonet enabl function interpret cellular tomogram without sub tomogram averag applic high resolut cellular tomogram also help identifi differ orient complex kind sub tomogram averag
D055032;D000077321
T059;T066
36,309,498
genom wide rare variant score associ morpholog subtyp autism spectrum disord defin differ genet subtyp autism spectrum disord asd enabl predict development outcom base minor physic major congenit anomali categor canadian children asd dysmorph nondysmorph subgroup develop method calcul patient level genom wide rare variant score grvs whole genom sequenc wgs data grvs sum number variant morpholog associ code non code region weight effect size proband dysmorph asd signific higher grvs compar nondysmorph asd p use polygen transmiss disequilibrium test observ transmiss asd associ common variant nondysmorph asd proband p find replic use wgs data asd proband accompani morpholog data simon simplex collect result provid support altern genom classif asd subgroup use morpholog data may inform intervent protocol
D000067877
T048
36,309,497
structur insight light driven anion pump cyanobacteria transmembran ion transport key process live cell activ transport ion carri various ion transport includ microbi rhodopsin mrs mrs perform divers function activ passiv ion transport photo sens other particular mrs pump various monoval ion like na k cl character mr propos pump sulfat addit halid belong cyanobacterium synechocysti sp pcc name synechocysti halorhodopsin syhr structur studi syhr may help understand make mr pump dival ion present crystal structur syhr ground state structur sulfat bound form well two photoreact intermedi k state data reveal molecular origin uniqu properti protein except strong chlorid bind propos pump dival anion shed light mechan anion releas uptak cyanobacteri halorhodopsin uniqu properti syhr highlight potenti optogenet tool may help engin differ type anion pump applic optogenet
D027321;D046939
T123;T007;T116
36,309,495
neuron camkk promot immunosuppress checkpoint blockad resist glioblastoma glioblastoma gbm notori immunosuppress tumor microenviron tme refractori immun checkpoint blockad icb identifi calmodulin depend kinas kinas camkk driver icb resist camkk high express pro tumor cell associ worsen surviv patient gbm host camkk specif reduc surviv promot icb resist multimod profil tme reveal camkk associ sever icb resist associ immun phenotyp camkk promot exhaust cd cell reduc expans effector cd cell addit limit tumor penetr camkk also maintain myeloid cell diseas associ microglia like phenotyp last neuron camkk requir maintain icb resist associ myeloid phenotyp deleteri surviv promot icb resist find reveal camkk contributor icb resist identifi neuron driver immunotherapeut resist gbm
D005909
T191
36,309,493
compet instabl reveal ration design control activ crosslink gel activ stress generat molecular motor set larg scale mechan cell cytoskeleton remain poor understood combin experi theori demonstr emerg properti biomimet activ crosslink gel depend properti microscop constitu show extensil nemat elastom exhibit two distinct activ driven instabl spontan bend plane buckl plane depend composit molecular motor play dual antagonist role fluidiz stiffen gel depend atp concentr demonstr activ elast stress set compon provid estim activ gel theori paramet final activ elast manipul situ light activ motor protein control direct instabl optic result highlight cytoskelet stress regul self organ live matter set foundat ration design optogenet control activ materi
D003599;D008870
T026
36,309,492
differenti traffick ligand trogocytos via cd versus ctla promot collect cellular control co stimul intercellular communic crucial collect regul cellular behavior cluster cell shown mutual control product key communic signal unclear whether also joint regul avail degrad use newli develop report system bioinformat analys protein structur model genet perturb assess find cell util trogocytosi compet antagonist receptor differenti control abund immunoregulatori ligand specif ligand trogocytos via cd shuttl cell surfac enabl co stimul neighbor cell contrast ctla mediat trogocytosi target ligand degrad mechanist fate separ control differ acid sensit receptor ligand interact receptor intracellular domain abil cd ctla confer differ fate trogocytos ligand reveal addit layer collect regul cellular behavior promot robust popul dynam
D018106;D018796
T129;T121;T116;T192
36,309,491
impact phosphorus project sub saharan africa food secur futur sub saharan africa must urgent improv food secur phosphorus avail one major barrier due low histor agricultur use share socioeconom pathway ssps indic sustain ssp fossil fuell futur ssp improv food secur term price avail risk hunger whilst nationalist ssp unequ ssp pathway worsen food secur furthermor sustain ssp requir limit cropland expans low phosphorus use whilst nationalist ssp environment damag fossil fuell pathway middl road futur ssp maintain today inadequ food secur level use approxim million tonn phosphat rock whilst within current global reserv estim market price alon common use fertilis dap would cost us billion agricultur period farmgat price could two five time higher due addit cost eg transport taxat etc thus improv food secur econom growth within sustain context ssp avoid nationalist ideolog ssp prioritis
D010758;D000383
T090;T196;T197
36,309,490
analysi anti sar cov omicron neutral antibodi titer differ vaccin unvaccin convalesc plasma sourc latest sar cov variant concern omicron immun escap therapeut anti spike monoclon antibodi wa vaccin elicit sera demonstr continu relev covid convalesc plasma ccp therapi lesson learnt previous usag ccp suggest focus earli outpati immunocompromis recipi high neutral antibodi titer unit systemat review omicron neutral plasma activ data report approxim ccp sampl unvaccin pre omicron donor neutral omicron ba low geometr mean geometr mean titer neutral gm gmt repres fold reduct wa neutral non convalesc subject receiv two dose mrna vaccin gm gmt omicron ba neutral howev plasma vaccine recov either previous pre omicron variant concern infect omicron ba infect third dose uninfect vaccine near neutral omicron ba ba ba gm gmt time higher pre omicron ccp fulli vaccin post ba plasma vax ccp gm gmt ba ba ba find implic ccp stock collect prior pandem period futur plan restart ccp collect thus vax ccp provid effect tool combat ongo variant escap therapeut monoclon antibodi
D000086402;D000086382
T005;T067;T047
36,309,488
adher impact home base high intens imt peopl spinal cord injuri pilot studi pilot studi complet phase control phase imt incorpor assess baselin bl bl follow f f f f
D001945;D013119
T061;T037
36,309,487
inhibit cd traf depend inflammatori activ halt onset diabet retinopathi streptozotocin diabet mice diabet initi inflamm impair retin vasculatur lead diabet retinopathi one lead caus blind inflammatori pathway examin potenti therapeut target diabet retinopathi still need earli stage treatment hypothes cd tnf receptor associ factor traf axi play pivot role onset diabet retinopathi cd traf axi would prime therapeut target earli stage non prolif diabet retinopathi cd traf complex initi nfb activ inflamm tissu damag cd traf constitut express muller glia upregul diabet retina yet role cd traf complex onset diabet retinopathi still unclear current studi examin cd traf axi diabet retinopathi use small molecul inhibitor smi streptozotocin induc diabet mice cd traf depend inflamm inhibit retin vascular leakag capillari degener amelior diabet mice collect data suggest cd traf axi play pivot role onset diabet retinopathi could novel therapeut target earli diabet retinopathi
D003921;D003930
T047;T050
36,309,486
desmoglein import islet function cell surviv type diabet complex diseas character lack endogen insulin secret pancreat cell although cell target autoimmun process cell dysfunct known occur type diabet complet understand cell cell interact support pancreat function still lack character pancreat endocrin compart studi pancreata healthi adult donor investig singl cell surfac adhes molecul desmoglein dsg genet modifi mice lack dsg examin islet cell mass insulin product respons glucos suscept streptozotocin induc mous model hyperglycaemia abil cure diabet syngen transplant model herein identifi dsg previous unrecogn adhes molecul support cell furthermor reveal dsg within top percent gene express human pancreat islet express insulin produc cell somatostatin produc cell dsg loss function mice dsg lolo observ signific reduct number pancreat islet islet size consequ less total insulin content per islet cluster dsg lolo mice also exhibit reduct blood vessel barrier integr increas incid streptozotocin induc diabet islet isol dsg lolo mice suscept cytokin induc cell apoptosi follow transplant diabet mice islet isol dsg lolo mice less effect wildtyp counterpart cure diabet vitro assay use beta tc murin cell line suggest dsg support actin cytoskeleton well releas cytokin chemokin taken togeth studi suggest dsg appreci regul cell function pancreat islet better understand adhes molecul may provid new opportun combat type diabet
D003921;D003922;D007515
T047;T050;T023
36,309,484
egfl drive evolut resist egfr inhibitor lung cancer activ notch signal accumul evid support evolutionari trait drug resist like resili system tumor cell experi drug toler state full resist acquir howev under mechan still poor understood identifi egf like domain multipl egfl respons gene epiderm growth factor receptor egfr kinas inhibit period tumor decim moreov data reveal adapt increas egfl process control depress nonsens mediat mrna decay nmd pathway upregul egfl activ notch signal lung cancer cell slow decreas c myc caus egfr inhibit therebi help surviv cancer cell data taken togeth demonstr egfl driver gene resist egfr kinas inhibit suggest target egflnotch signal may improv clinic benefit egfr inhibitor patient egfr mutant tumor
D016228;D008175
T123;T191;T116
36,309,483
polygen heterogen antidepress treatment placebo respons genet architectur antidepress respons poor understood polygen risk score prs explor placebo respons use sub scale might provid insight investig associ prss relev complex trait respons vortioxetin treatment placebo use clinic scale includ sub scale self report assess collect clinic test sampl major depress disord mdd patient treat vortioxetin n placebo n seven random doubl blind clinic trial parallel obtain data observ web base studi vortioxetin treat patient n self report respons prss antidepress respons psychiatr disord symptom trait deriv use summari statist well power genom wide associ studi gwas associ test perform prss treatment respons two test sampl empir p valu evalu clinic test sampl prss signific associ respons vortioxetin treatment placebo follow bonferroni correct howev clinic assess treatment respons prs nomin associ vortioxetin treatment placebo respons given sever secondari outcom scale improv ham ham psychic anxieti sub scale cpfq pdq p higher subject well prs p lower depress prs p nomin associ higher placebo respons self report test sampl higher schizophrenia prs signific associ poorer self report respons p identifi prss explain low proport varianc placebo treatment respons although result limit believ prs associ bear unredeem potenti predictor treatment respons well power phenotyp similar gwas base becom avail
D003865
T048
36,309,482
bromodomain contain protein brd epigenet regul fatti acid metabol gene ferroptosi reprogram lipid metabol consid fundament step tumourigenesi influenc ferroptosi howev molecular mechan lipid metabol ferroptosi remain larg unknown result drug screen inhibitor target appli ferroptosi cell indic inhibitor target bromodomain contain protein brd signific inhibit erastin induc ferroptosi function studi prove loss brd weaken oxid catabol mitochondria protect cell excess accumul lipid peroxid mechan research reveal transcript level fatti acid metabol relat gene hadh acsl acaa particip oxid fatti acid fao polyunsatur fatti acid pufa synthesi depend activ super enhanc ses form brd hmgb promot region conclus studi demonstr brd indispens fatti acid metabol base epigenet regulatori mechan affect erastin induc ferroptosi provid new theoret refer understand relationship lipid metabol ferroptosi deepli
D000079403
T043
36,309,470
evalu microleakag push bond strength various composit resin seal screw access channel implant support restor microleakag loss composit resin seal screw access channel frequent complic screw retain implant support prosthes screw access channel best restor reduc complic unclear
D003763;D015921
T046;T074
36,309,469
comparison accuraci impress made implant interf axial converg cad cam impress cope alter cast techniqu vitro studi studi evalu accuraci differ method make impress implant close proxim advers axial converg lack
D003761;D015921
T061;T074
36,309,468
individu variat distanc nasion frankfort horizont plane error factor facebow semi adjust articul semi adjust articul use averag axi facebow nasion relat fix distanc mm mm orbital anterior refer point locat axi orbit plane major factor measur sagitt condylar inclin later cephalometr radiograph allow measur distanc nasion frankfort horizont plane shown great variabl among patient
D003725;D005145
T074;T029
36,309,467
innov fix prosthodont workflow systemat approach treat complet mouth reconstruct essenti achiev optim treatment result current convent method alway provid fulli control set util digit ecosystem allow creat predict effici workflow fix prosthodont reconstruct
D017076;D011476
T091;T066
36,309,462
five patient spinal muscular atrophi progress myoclon epilepsi sma pme novel pathogen variant treatment review literatur spinal muscular atrophi progress myoclon epilepsi sma pme rare inherit autosom recess diseas due bi allel mutat asah gene sma pme character progress muscl weak three seven year age accompani epilepsi intract seizur sometim sensorineur hear loss best knowledg case report present studi report five patient four differ famili affect sma pme character progress myoclon epilepsi proxim weak lower motor neuron diseas proven electrodiagnost studi genet analysi identifi two differ mutat asah nm gene previous report pathogen variant cc pthrmet novel like pathogen variant cc pprothr addit report novel pathogen variant asah gene caus sma pme diseas studi compar sign phenotyp genet find case seri previous report discuss symptomat treatment
D020191;D009134;D016472
T047
36,309,459
melissa officinali essenti oil antimicrobi agent listeria monocytogen watermelon juic burden foodborn ill negat effect public health also countri economi melissa officinali aromat plant known biolog properti includ antioxid antimicrobi effect work highlight officinali essenti oil antioxid potenti antimicrobi activ l monocytogen present bactericid action abl inhibit virul attribut biofilm format pre exposur bacterium subinhibitori level essenti oil lml induc high toler stress high temperatur low ph osmot stress desicc cross resist antibiot modifi invas abil caco cell appli food model media lettuc chicken milk watermelon juic essenti oil show antimicrobi activ lettuc leaf model medium diminish l monocytogen contamin inhibit natur microbiota present watermelon juic officinali essenti oil show potenti use control l monocytogen watermelon juic increas food microbi shelf life
D008089;D009822;D031334;D029773;D000890
T121;T007;T109;T168;T002
36,309,458
chameleon like microb promot microecolog differenti daqu chameleon like microb ferment communiti intern factor facilit transform communiti correspond homeostasi state specif environment condit high temperatur daqu form three typic microecolog prepar process make ideal system studi chameleon like microb studi integr multi omic method metaproteom determin neurospora crassa aspergillus nidulan bacillus subtili oceanobacillus iheyensi chameleon like microb regul metabol differ five member heterocycl amino acid daqu result microecolog differenti synthet microbi consortia consist four chameleon like microb without domin function bacteria saccharopolyspora erythraea virgibacillus haloimitrifican ferment simul situ condit communiti construct microorgan greater function divers robust metabolom similar situ system expos environment disturb function divers help maintain communiti stabil increas dissimilar chameleon like microb communiti form differ homeostasi
D001419;D059013
T007;T001
36,309,457
penicillium digitatum antifung protein pdafpb show high activ mycobiota involv slice bread spoilag studi aim isol identifi fungal speci involv slice bread spoilag evalu suscept antifung protein fungal origin afp protein includ pdafpb penicillium digitatum peafpa peafpb peafpc penicillium expansum base morpholog criteria group sixteen fungal isol select subsequ identifi speci level use sequenc analysi penicillium speci predomin mycobiota identifi base combin phylogenet analysi use tubulin sequenc p roqueforti p brevicompactum p chrysogenum p crustosum abund speci aspergillus versicolor aspergillus niger bissochlami spectabili also identifi regard antifung activ afp pdafpb peafpa potent protein sinc growth test fungi complet inhibit concentr rang gml peafpb show moder antifung activ wherea peafpc least activ protein best vitro afp pdafpb peafpa also evalu situ protect assay p roqueforti pdafpb provok clear reduct p roqueforti growth slice bread sampl suggest afp protect effect bread studi underlin potenti afp test particular pdafpb altern antifung agent extend slice bread shelf life
D001939;D010407
T168;T004
36,309,456
combin treatment polylysin heat damag protect structur spore inner membran inactiv bacillus subtili spore steril effect combin heat c polylysin pl gl treatment bacillus subtili spore investig compar convent heat steril inactiv rate spore chang protect structur evalu use differ method techniqu chang cell membran fatti acid cell wall protein nucleic acid also analyz result show combin heat pl treatment signific p inactiv bacillus subtili spore compar singl heat treatment besid inactiv spore enhanc temperatur pl concentr combin treatment increas inactiv rate found log heat c min combin addit gl pl addit electr conduct spore suspens posit region flow cytometri signific p increas depend temperatur pl concentr combin treatment indic signific damag cell membran increas permeabl signific chang spore morpholog also observ microscopi analysi combin treatment furthermor fourier transform infrar spectra indic phase chang inner membran alter structur peptidoglycan layer well protein nucleic acid denatur combin treatment therefor combin heat pl treatment suggest steril altern convent heat steril food industri
D001412;D009696
T123;T007;T114
36,309,455
develop applic multiplex pcr method differenti salmonella enterica serovar typhimurium monophas variant pig farm salmonella enterica serovar typhimurium monophas variant salmonella increas dramat caus human salmonellosi colon pig differ typhimurium monophas variant typhimurium lose gene cassett encod second phase flagellin establish rapid method detect differenti two serotyp analyz publish genom typhimurium monophas variant found salmonella strain carri fljb hin gene therefor establish novel multiplex pcr method use fljb hin region mdh gene target sequenc detect differenti serotyp method use specif detect serotyp detect limit dna concentr pgl addit pcr assay success differenti typhimurium isol isol monophas variant preserv laboratori correspond whole genom base serotyp result applic multiplex pcr method fecal sampl pig farm identifi typhimurium monophas variant consist whole genom base serotyp result multiplex pcr assay rapid precis method detect typhimurium monophas variant sampl across food product chain
D012480;D019779
T047;T007
36,309,454
protect role acinetobact bacillus escherichia coli h biofilm sodium hypochlorit extracellular matrix degrad enzym foodborn pathogen bacteria multi speci biofilm food manufactur facil suspect caus cross contamin lead foodborn ill studi cafeteria kitchen associ bacteri isol protect effect e coli h biofilm extracellular polymer substanc ep degrad enzym sodium hypochlorit investig multi speci biofilm form abil efficaci ep degrad enzym use crystal violet assay suscept e coli h sodium hypochlorit naclo evalu use propidium monoazid combin quantit pcr pma qpcr combin treatment enzym follow naclo also test cafeteria kitchen isol acinetobact bacillus abl form biofilm sever show protect effect e coli h naclo form multi speci biofilm particular acinetobact protect effect e coli h also notic enzym combin treatment naclo result give us insight protect role food associ environment bacteria e coli h biofilm common sanit warrant studi develop effect control method studi also highlight import prevent contamin biofilm format environment microorgan eventu reduc foodborn ill
D019453;D000150;D001407;D005517
T007;T037
36,309,453
applic natamycin farnesol bioprotect agent inhibit biofilm format yeast foodborn bacteri pathogen appl juic process line biofilm serv reservoir pathogen spoilag microorgan remov differ surfac recur problem beverag industri studi aim investig effect combin natamycin nat mmoll farnesol far mmoll biofilm ultrafiltr uf membran stainless steel ss surfac use appl juic food matrix co adhes rhodotorula mucilaginosa candida tropicali c krusei c kefyr mix yeast listeria monocytogen salmonella enterica escherichia coli h multi speci presenc nat far evalu h biofilm treat nat far observ cell quantif microscopi inhibit filament yeast form disrupt tri dimension structur high detach yeast cell nat far affect biofilm independ surfac use presenc bacteria l monocytogen suscept p multi speci biofilm follow e coli h surfac p wherea growth enterica reduc p sinc combin nat far affect structur viabil yeast speci foodborn pathogen multi speci biofilm develop uf membran ss surfac combin propos could consid promis control agent prevent biofilm appl juic process line
D027845;D019453;D008089
T168;T007;T002
36,309,452
rapid detect listeria monocytogen dairi product novel chemilumonogen approach routin monitor foodborn pathogen listeria monocytogen food process environ time consum necess ensur food safeti altern rapid diagnost method pathogen detect increas use often demand special equip make unsuit site test short communic describ success demonstr combin sampl prepar method matrix lysi chemiluminesc base detect platform aquaspark detect l monocytogen milk yogurt propos method evalu qpcr result relat specif foodstuff relat sensit milk well yogurt bacteri level cfuml low initi bacteri concentr cfuml diverg result found highlight advantag limit method less suscept contamin fals posit result non grow dead cell qpcr slight lower overal detect limit howev point qpcr increas analyt cost also requir addit h analysi time studi demonstr first success applic chemilumonogen detect approach l monocytogen food high potenti site test
D008089
T007
36,309,451
cross contamin escherichia coli h listeria monocytogen viabl non cultur vbnc state wash leafi green reviv shelf life water disinfect treatment chlorin chlorin dioxid use fresh cut industri maintain microbiolog qualiti process water pw inactiv bacteri cell water also lead induct intermedi state viabl non viabl known viabl non cultur vbnc state viabl cell particip cross contamin event signific vbnc cell pw transfer product potenti resuscit capac storag unclear present studi aim determin first vbnc cell present pw cross contamin leafi green wash second potenti reviv shelf life process water character high chemic oxygen demand due presenc high level organ matter inocul listeria monocytogen escherichia coli h inocul pw treat min chlorin dioxid mgl chlorin mgl generat vbnc cell absenc cultur cell confirm plate count vbnc cell viabil quantit polymeras chain reaction v qpcr complement two dye ethidium ema propidium pmaxx monoazid cross contamin shred lettuc demonstr monitor vbnc cell wash product min contamin pw shelf life day c case l monocytogen consid total concentr l monocytogen vbnc cell present pw low proport cell abl cross contamin product wash vbnc l monocytogen cell abl resuscit product shelf life although level cultiv bacteria close limit detect log cfug detect end storag hand vbnc cell e coli h present pw abl cross contamin shred lettuc wash moreov shred lettuc artifici inocul vbnc e coli h resuscit vbnc cell storag day c observ base result obtain injur l monocytogen cell present pw abl transfer product wash vbnc l monocytogen cell present leafi green shred lettuc babi spinach resuscit although cultiv number remain low take result togeth could conclud industri condit vbnc cell transfer water product wash capac resuscit leafi green storag low
D019453;D008089
T007
36,309,450
character microbi communiti assembl new wooden vat use chees product wooden vat use product tradit chees biofilm wooden vat surfac known transfer larg quantiti microb chees howev studi investig microbi composit biofilm newli develop wooden vat communiti assembl evolv present studi microbi communiti biofilm character activ process new wooden vat use amplicon sequenc bacteri rrna fungal intern transcrib spacer gene result show microb whey effect develop wooden vat lactococcus high domin throughout vat activ process substanti increas relat abund acetobact lactobacillus end vat activ day contrast fungal communiti stabil earli day domin kluyveromyc predict function correspond differ stage biofilm format wherebi function associ biofilm initi enrich day associ growth matur enrich day microbi success wooden vat surfac expect reproduc base earli onset domin determinist process
D002611;D064307
T001;T168;T032;T028
36,309,449
non redund natur lactiplantibacillus plantarum plasmidom reveal compar genom analysi strain lactiplantibacillus plantarum homofer lactic acid bacterium lab often found ferment food mani strain display probiot properti strain belong l plantarum stress toler metabol flexibl lactobacilli display larger genom higher plasmid abund studi aim understand whether plasmid play particular role l plantarum compar chromosom compar genom analysi assess chromosom plasmid strain public avail complet genom sequenc reveal major plasmid encod protein famili pfs encod chromosom abund pfs uniqu plasmid contain hypothet protein other involv exopolysaccharid biosynthesi biofilm format stress toler carbohydr metabol sequenc common plasmid encod chromosom encod pfs differ suggest might exhibit differ biochem properti common pf gene predomin present larger plasmid point anoth possibl way reduc redund encod share pfs low copi number plasmid overal studi demonstr uniqu contribut plasmid versatil surviv evolutionari success l plantarum also highlight need function character hypothet protein encod
D019936;D048191
T007
36,309,448
role siderophor pseudomona fluorescen biofilm format spoilag potenti function investig function pyoverdin biofilm format motil spoilag potenti pseudomona fluorescen target identifi two major gene pvda pvde involv biosynthesi siderophor next construct pvda pvde mutant p fluorescen pf found delet pyoverdin led biofilm motiv transit pvda pvde mutant display enhanc motil reduc level exopolysaccharid epss attenu biofilm format addit lack synthesi pyoverdin promot spoilag fish fillet store c base effect pyoverdin delet phenotyp report pyoverdin regul transcript level htpx phoa flip flga rpos suggest pyoverdin mediat iron absorpt may affect regul flagellum stress resist studi emphas import role pyoverdin format biofilm motil spoilag p fluorescen pf
D017262;D011551
T123;T007;T109
36,309,447
chang resistom profil potenti probiot lactiplantibacillus pentosus respons edibl oil adapt despit increas interest investig horizont gene transfer lead caus antibiot resist spread resistom influenc influx efflux gene differ environ rather express exist gene differ stress condit requir special attent studi determin whether pre adapt lactiplantibacillus pentosus strain isol alorea green tabl oliv veget base edibl oil influenc phenotyp genotyp respons antibiot signific diet food matrix gut health food safeti concern pre adapt l pentosus strain oil signific chang suscept profil antibiot howev result general differ among three strain although chang minimum inhibitori concentr mic antibiot occur depend l pentosus strain oil use adapt pre adapt l pentosus strain oliv sunflow argan linse oil induc gene express eg rpsl reca uvrb sever stress respons thus analyz fact depth transcript chang report select potenti probiot l pentosus cf adapt oliv sunflow rerout metabol pathway export toxic molecul efflux pump abc transport pre adapt lactobacilli oliv sunflow oil may repres novel approach manufactur probiot product improv stabil function robust
D000070018;D019936;D031658
T168;T007;T002
36,309,446
cold toler microorgan caus spoilag vacuum pack beef time temperatur abus determin cultur qpcr vacuum packag storag condit chill temperatur common use order prolong shelf life meat condit time temperatur abus cold toler facult anaerob spoilag microorgan continu grow studi investig growth six relev spoilag microorgan vacuum pack beef n subsampl store c day use cultur qpcr method correspond six qpcrs newli developedmodifi total bacteria lactic acid bacteria lab enterobacteral total fungi kazachstania psychrophila cold toler clostridium spp besid microbi quantif four spoilag appear meat gas product spoilag odor drip loss meat color observ result obtain cultur qpcr show total bacteria lab enterobacteral reach stationari phase day spoilag paramet gas product statist increas deviat odor detect fastidi cold toler clostridium spp k psychrophila could detect day base microbiolog sensori analysi result maximum shelf life vacuum pack beef store c day develop qpcr potenti use altern method cultur determin microbi growth
D018857;D005506
T068;T073;T067
36,309,445
candida krusei major contamin ultrafiltr revers osmosi membran use cranberri juic product ultrafiltr uf revers osmosi ro common use clarif concentr fruit juic howev one main limit filtrat membran biofoul reduc membran effici contamin filter product lead spoilag studi microbi foul layer uf ro membran canadian cranberri juic process plant character unlik microbiota found cranberri juic domin bacillus sp bacteria uf ro membran main colon sever strain yeast candida krusei variat bacteri yeast count observ tubular uf spiral wound ro membran analysi spatial distribut highlight homogen contamin across membran surpris ro membran higher level contamin compar uf membran furthermor six strain c krusei character multilocus sequenc type analysi five exhibit uniqu allel profil two found contain new trp allel
D014462;D029799
T061;T168;T002
36,309,444
growth food born pathogen listeria salmonella spore form paenibacillus bacillus commerci plant base milk altern object present studi compar growth food pathogen listeria monocytogen salmonella enterica food spoilag bacillus subtili industri milk product isol spore form paenibacillus commerci avail ultrahigh temperatur process uht bovin milk non dairi plant base beverag coconut almond cashew store chill ambient temperatur c c c beverag sampl inocul strain cocktail individu strain either listeria salmonella paenibacillus bacillus respect approxim cfuml find indic bacteri strain use studi capabl prolifer plant base beverag higher rate bovin milk c c listeria c salmonella paenibacillus respect bacillus subtili grew equal fast bovin milk plant base almond drink c statist signific differ p growth rate differ type test beverag observ c c listeria salmonella cocktail respect data suggest plant base beverag may present signific risk listeriosi salmonellosi post open recommend care consid
D056507;D001407;D008087;D008089
T007
36,309,443
plant base natur flavonoid show strong inhibit aflatoxin product relat gene express correl chemic structur aflatoxin strong carcinogen mutagen fungal metabolit aflatoxin contamin critic issu agricultur food product natur flavonoid suppress aflatoxin biosynthesi howev structur activ relationship remain unclear present studi total structur relat natur flavonoid test aflatoxigen aspergillus flavus vitro situ maiz kernel investig structur activ relationship biolog activ aflatoxin product ic valu gml express relat gene afld aflk aflq aflr found strong inhibit structur activ relationship studi reveal oh ch group posit ring posit ring b close associ antifung antiaflatoxigen activ find provid valuabl inform develop clean safe method prevent aflatoxin contamin food
D000348
T131;T109
36,309,442
systemat review meta analysi indic substanti burden human norovirus shellfish worldwid gii gii predomin genotyp human norovirus hunov found lead caus acut gastroenter outbreak age group signific correl consumpt shellfish studi contamin hunov shellfish estim systemat review meta analysi studi contamin hunov shellfish search pubm web scienc embas cochran librari januari august total studi includ pool hunov preval shellfish ci worldwid reveal result subgroup meta analysi preval domin genogroup variabl ci ci ci sampl respect contamin gi alon gii alon gi gii hunov preval shellfish europ america asia ci ci ci respect ci africa furthermor preval hunov shellfish highest spring ci winter ci lowest summer ci oyster clam mussel compar hunov preval ci ci ci respect preval hunov shellfish harvest area market ci ci respect result studi suggest substanti burden hunov shellfish worldwid gii gii predomin genotyp studi provid inform regard contamin hunov shellfish worldwid contribut develop appropri control measur prevent shellfish relat hunov gastroenter
D029322;D010125;D005759;D049872;D017250
T005;T204;T047
36,309,441
high pressur process control salmonella raw pet food without compromis fresh appear impact acidul frozen storag trend feed dog cat raw pet food claim health benefit pose health concern due occurr pathogen bacteria high pressur process hpp allow non thermal inactiv microorgan preserv nutrit characterist minim impact organolept trait food present studi aim evalu model effect hpp applic mpa min inactiv salmonella endogen microbiota colour raw pet food formul differ concentr lactic acid gkg natur antimicrobi addit effect subsequ frozen storag pressur product assess salmonella inactiv rang log depend combin condit accord polynomi model obtain effect pressur linear quadrat term also includ hold time depict occurr resist tail ca min effect lactic acid depend pressur level relev treatment mpa frozen storag hpp prevent pathogen recoveri caus salmonella inactiv enhanc lactic acid treatment endogen microbi group signific reduc hpp detect level sever condit general littl effect hpp instrument colour paramet observ except slight increas light hard appreci visual observ high pressur process emerg relev technolog control salmonella spp manag microbiolog safeti raw pet food mathemat model use decis support tool design safer raw pet food keep desir fresh appear product
D002371;D004283
T047
36,309,440
bacteri communiti develop divers first year product new salmon process plant bacteri divers load equip food process facil constant influenc raw materi water air staff despit regular clean disinfect bacteria may persist therebi potenti compromis food qualiti safeti littl known bacteri communiti new food process facil gradual establish develop bacteri communiti newli open salmon process plant studi first day first year oper focus persist bacteri communiti surfac sampl done strateg sampl point clean disinfect studi divers dynam isol select sampl time point classifi oxford nanopor technolog base rep pcr amplicon sequenc rep seq supplement rrna gene rpod gene sequenc pseudomona overal increas bacteri number observ food contact surfac slaughter depart fillet depart non food contact surfac fish chang tempor spatial divers communiti composit observ approach reveal high point specif bacteri communiti
D005516;D012474
T067;T013
36,309,439
acid shock protein asr induc protein aggreg promot e coli h enter viabl non cultur state high pressur carbon dioxid stress stress condit bacteria enter viabl non cultur vbnc state surviv vbnc cell lost abil grow routin cultur medium still aliv may reviv suitabl condit reviv cell consum nutrient produc toxin lead food spoilag human ill pose great risk food safeti public health previous report high pressur carbon dioxid hpcd environ friend steril technolog induc vbnc format howev under mechan unclear perform comprehens transcriptom analysi reveal hpcd initi high express asr encod acid shock protein could promot vbnc format e coli h quantit revers transcript pcr analysi suggest high express asr inhibit acid resist ar system result endogen proton accumul ii inhibit hcha express protein stabil factor two effect result endogen protein aggreg high correl vbnc format accord hpcd stress cell exhibit decreas effici electron transfer chain atp product also contributori cytoplasm protein aggreg taken togeth hpcd initi high express asr coupl decreas atp product led protein aggreg final promot cell enter vbnc state
D019453
T007
36,309,438
applic enterocin whey film reduc listeria monocytogen contamin ripen chees enterocin whey solut obtain grow enterococcus faecali lbk lak sweet whey enterocin whey solut ew incorpor gelatinglycerol film test control listeria monocytogen film contain enterocin produc either strain ew l ew k film shown serv suitabl matrix bacteriocin releas preserv anti listeri activ day appli chees ew l ew k film abl reduc l monocytogen contamin undetect level day respect prevent migrat pathogen film chees incorpor ew film affect p moistur content solubl permeabl water vapor limonen elong break compar control film without ew howev thick swell index tensil strength higher p ew film result suggest activ ew gelatinglycerol film could effect safe applic control l monocytogen chees addit use chees whey cultur medium product bacteriocin complement incorpor film formul packag materi repres altern approach reus product chees product
D008089;D002611;D001430
T168;T007;T123;T116
36,309,437
induct viabl noncultur salmonella spp liquid egg mild heat subsequ resuscit salmonella spp one lead caus foodborn outbreak worldwid salmonella spp associ varieti food sourc particular egg product enter viabl noncultur vbnc state respons harsh stress vbnc cell still retain membran integr metabol activ may pose health risk howev format mechan resuscit abil vbnc cell well understood work salmonella spp cocktail includ salmonella enterica serovar newport salmonella enterica serovar enteritidi liquid egg product induc vbnc state mild heat treatment common use method inhibit growth pathogen liquid egg industri mild heat induc vbnc cell found resuscit liquid egg yolk ley liquid whole egg lwe fail recov liquid egg white lew addit certain number cell remain vbnc state vitro digest membran vesicl mv protein encod gene pagc two compon system encod gene phopq sigma factor encod gene rpos high express vbnc cell compar cultur counterpart result studi contribut better understand health risk associ salmonella spp vbnc state provid theoret basi format mechan vbnc state
D006358;D019779
T070;T007
36,309,436
solubl extracellular polymer substanc sep histo blood group antigen hbga express bacterium sphingobacterium sp sc influenc surviv persist norovirus lettuc foodborn norovirus nov outbreak link leafi green common due lack effici strategi prevent nov spread contamin surfac previous found sphingobacterium sp sc lettuc phyllospher express histo blood group antigen hbga like substanc solubl extracellular polymer substanc sep contribut nov adher lettuc extract sep bacterium sc sep sc analyz chemic composit examin role surviv protect nov surrog murin norovirus mnv tulan virus tuv lettuc presenc sep sc signific increas surviv persist human nov hunov mnv tuv day compar virus alon hunov tuv mnv seed sep sc resist heat c min virus alon sep sc also increas viral resist sodium hypochlorit inactiv treatment ppm bleach c min howev sep sc effect protect virus uv inactiv bind tuv sc bacteria sep sc visual use transmiss electron microscopi suggest protect might relat direct interact sep sc viral particl studi provid import insight help inform strategi improv food safeti
D029322;D001789;D045249
T185;T129;T005;T007
36,309,435
character polysulfid saccharomyc cerevisia cell finish wine cystein supplement model grape medium polysulfid degrad wine result hydrogen sulfid h releas impart rotten egg smell detriment wine qualiti although presenc wine polysulfid demonstr biogenesi remain unclear studi investig role saccharomyc cerevisia polysulfid format ferment without mm cystein supplement h sourc use establish liquid chromatographi tandem mass spectrometri method monobromobiman deriv hydropolysulfid includ cyssssh cysssssh gssssh two oxid polysulfid gssg gssssg detect yeast cell end ferment grape juic like medium polysulfid product four cerevisia singl delet mutant cys cys met tum show signific differ compar suggest uncharacter pathway maintain cellular polysulfid homeostasi five mm cystein addit increas format shorter sulfur chain speci includ gss biman gssg elev level longer sulfur chain speci addit polysulfid even number sulfur atom tend predomin cellular lysat oxid polysulfid longer chain hydropolysulfid detect finish wine evid suggest polysulfid unstabl wine like environ transport extracellular collect data illustr complex yeast polysulfid metabol ferment condit
D014920;D027843
T129;T168;T116;T002
36,309,434
meat deriv escherichia coli pseudomona fragi manag co exist dual speci biofilm adjust gene regul competit strength pseudomona fragi escherichia coli consid common colon fresh spoilag meat tend live proxim studi primarili test interplay pattern differ isol two speci two two combin grown stainless steel surfac dual speci biofilm result show two speci present competit major observ interplay pattern biofilm progress independ bacteri strain growth temperatur c c one dual speci combin propos repres explor dynam pattern interact strength two speci speci colon order taken consider biolog effector first report prior colon one speci signific decreas initi colon cell count counterpart speci one three order magnitud compet limit adhes surfac e coli observ aggress surfac colon compar p fragi howev spatial structur microbi composit matur dual speci biofilm observ signific affect find also shed new light evid e coli p fragi respect enhanc biofilm format capabl upregul express level gene encod type fimbria phosphat respons regul dual speci consortia progress could serv crucial factor improv difficulti food biocontrol
D044206
T007
36,309,433
evalu influenc oper paramet puls light wine relat yeast focus inter intra specif variabl sensit oenolog grow demand consum wine produc less input sulphit frequent use microbi control emerg control method manag microorgan wine wide studi studi effici puls light pl treatment investig drop plat system use evalu impact three pl oper paramet fluenc per flash total fluenc flash frequenc fluenc per flash appear key paramet prior total fluenc thus demonstr import effect peak voltag pl treatment effici pl treatment assess strain distribut amongst fourteen yeast speci relat wine environ import variabl pl respons observ brettanomyc bruxellensi strain strong sensit pl intraspecif variat pl appli red wine inocul strain b bruxellensi saccharomyc cerevisia lachancea thermotoleran result confirm interspecif respons variabl higher sensit b bruxellensi speci pl wine treatment total fluenc j cm result log reduct differ b bruxellensi strain result highlight potenti pl wine microbi stabil
D014920;D055168
T168;T004
36,309,432
multipl region high resolut melt base method accur differenti food deriv yeast speci level resolut yeast compris diverg group microorgan play import role food product monitor product process valid authent safeti food reliabl method yeast identif differenti need nowaday tradit pcrsequenc base method replac rapid techniqu requir post pcr process present studi develop three region base qpcr hrm protocol rapid differenti yeast speci isol food product three target fragment rdna rdna care analyz dock primer inter speci conserv region flank polymorph region bp thirti eight yeast strain use train materi collect yeast span pichia clavispora candida yarrowia kluyveromyc saccharomyc wickerhamomyc genera maldi tof mass spectrometri convent rdna sequenc use valid conduct studi demonstr use individu three region analyz qpcr hrm possess yeast speci specif limit sometim lead inaccur taxonom classif hand simultan analysi three propos region result rapid adequ differenti yeast strain speci level resolut
D015003;D004718
T004
36,309,431
tio base photocatalyst generat reactiv oxygen speci caus cell membran disrupt staphylococcus aureus escherichia coli h photocatalyst includ titanium dioxid tio attract much attent food safeti control foodborn pathogen howev studi photocatalyt activ various food surround media factor affect efficaci photocatalyt inactiv incomplet studi inactiv foodborn pathogen food surround environ tio base photocatalyst ultraviolet uva nm visibl light vis nm employ three tio base photocatalyst name degussa p tio carbon modifi kronoclean c tio pt dope ishihara sangyo mpt pt tio inactiv staphylococcus aureus escherichia coli h expos uva vis light water air sampl among degussa p uva show highest bactericid effect water air treatment induc log reduct aureus treat jcm e coli h reduc log jcm water sampl air treatment combin degussa p uva achiev log reduct staphylococcus aureus e coli h respect develop laboratori scale chamber h jcm scaveng assay show regardless photocatalyst wavelength use reactiv oxygen speci ros generat caus cell membran disrupt foodborn pathogen howev type ros generat vari among photocatalyst relat differ bactericid efficaci result indic tio base photocatalyt activ use control microbiolog hazard various environ food industri
D019453;D013203
T047;T007
36,309,430
warm climat ventil indoor temperatur outdoor relat humid signific effect campylobact spp colon chicken broiler farm occur day longitudin studi conduct five convent broiler farm year period determin dynam campylobact infect warm climat region north eastern spain week sampl flock perform upon one day old chick placement includ anim environment sampl campylobact spp detect assess cultur non cultur method environment sampl also obtain clean disinfect hous prior chick placement thirti nine flock becam colon grow period first bird excret campylobact detect day old chick earliest whole flock becam posit day age latest day campylobact detect chicken whole flock colon within day campylobact farm preval posit flock rang four five farm remain farm show lower preval logist regress model show campylobact infect like higher minim indoor temperatur well higher minim outdoor relat humid characterist warm climat mediterranean countri ventil type also signific p clear farm effect season observ biosecur improv special hous level need broiler farm prevent flock colon reduc current high flock preval
D002169;D011201;D002167
T047;T007
36,309,429
depth multiphas analysi chocol product chain bean bar demonstr superior saccharomyc cerevisia hanseniaspora opuntia function starter cultur cocoa ferment hanseniaspora opuntia common found yeast speci natur ferment cocoa pulp bean mass need depth investig present studi aim examin effect cocoa isol h opuntia imdo part three differ starter cultur mixtur compar spontan ferment regard microbi communiti substrat consumpt metabolit product dynam includ volatil organ compound voc phytochem composit well composit cocoa bean ferment cocoa liquor chocol inocul h opuntia strain unabl prevail background yeast present ferment cocoa pulp bean mass led ferment cocoa bean four day ferment howev reflect higher level polyphenol cocoa ferment process inocul saccharomyc cerevisia strain enhanc flavour product ferment dri step reflect richer reproduc aroma profil cocoa liquor chocol sensori analysi cocoa liquor chocol demonstr cerevisia led acid note compar spontan ferment result advanc ferment degre final differ voc profil found cocoa bean throughout whole chocol product chain depend ferment process
D000069956;D055549;D002099;D007887
T168;T002;T109
36,309,428
quantif hepat e virus raw pork liver use droplet digit rt pcr hepat e virus hev causat agent hepat e rise hepat e infect china may link undercook pork studi establish revers transcript droplet digit pcr rt ddpcr method detect hev raw pork liver detect limit assay hev rna low copiesl suggest approach valid sampl demonstr greater sensit specif anti interfer perform featur rt qpcr furthermor amplifi partial orf gene nest rt pcr sequenc hev rna posit sampl preval hev collect sampl viral load copiesl copiesl specif virus detect sampl collect bio safeti dispos center dead livestock poultri sampl collect slaughterhous none sampl collect retail market hev rna posit subsequ phylogenet analysi reveal hev isol belong subtyp one common subtyp northern china
D016752;D016751;D000080305;D000069466;D013553
T168;T005;T047
36,309,427
preval campylobact speci associ risk factor contamin dairi product collect dri season major milk shed ethiopia cross section studi conduct investig preval risk factor contamin ethiopian dairi product campylobact total dairi food sampl collect establish studi particip interview sampl test campylobact follow iso standard pcr confirm campylobact detect test food sampl detect campylobact c jejuni highest preval c jejuni found raw milk follow pasteur milk cottag chees p use warm water soap clean cow udder teat farm reduc likelihood detect campylobact milk aor p filter milk cloth use plastic filter aor p store milk aluminum contain aor p reduc likelihood detect campylobact milk collect facil contrast campylobact detect signific like milk collect collect center concret floor aor p odd detect campylobact milk time greater aor p milk process facil calibr pasteur annual basi final separ refriger milk storag reduc odd detect campylobact retail aor p
D002167;D016123
T007
36,309,426
marin increas tyramin level rainbow trout fillet strip packag modifi atmospher marinad increas use manufactur raw fish product correspond meat marin known major effect composit microbiom effect marin fish known well knowledg gap prompt studi microbi ecolog amin format marin unmarin modifi atmospher commerci packag rainbow trout fillet strip accord find marin increas maximum concentr log cfug psychrotroph bacteria one logarithm unit led time higher averag tyramin concentr correspond unmarin product instead trimethylamin concentr time higher unmarin product marin one accord rrna sequenc analys lactic acid bacteria lab predomin marin strip one day use date wherea unmarin strip fusobacteriacea lab domin taxa base cultur depend analysi latilactobacillus fuchuensi prevail lab product sinc subset l fuchuensi strain test abl produc tyramin vitro hypothesis use acid marinad activ product tyrosin decarboxyl enzym l fuchuensi led increas tyramin concentr
D017686
T013
36,309,424
prostat endocrin organ modul serum testosteron asid nonmelanoma skin cancer prostat cancer common cancer among men unit state benign prostat hyperplasia common benign tumor found men recent endocrin function possibl influenc hypothalam pituitari axi relat understudi review summar current understand potenti endocrin function prostat cancer benign prostat tissu
D011470;D011471
T047;T191
36,309,423
testosteron replac option treatment male hypogonad complic multitud treatment avail lack clear understand differ treatment modal barrier treatment patient mispercept unrealist expect anxieti articl intend help practition better understand challeng testosteron replac option order better counsel treat patient hypogonad
D013739;D007006
T125;T121;T047;T109
36,309,422
testosteron assay challeng accur precis measur testosteron includ defici standard variabl refer rang expens relat gold standard equip challeng total testosteron remain access standard laboratori free testosteron bioavail testosteron may use adjunct particular men low borderlin testosteron valu mass spectrometri gold standard measur modal total testosteron equilibrium dialysi follow direct assess trust method gold standard techniqu measur free testosteron although refer rang may vari effort adapt refer rang differ popul includ age adjust valu
D013739;D007006
T125;T121;T047;T109
36,309,421
androgen steroid use abus past present futur androgen steroid abus elit athlet decad perform enhanc properti sport involv strength power confirm class ban elit athlet competit sinc mid risk withdraw syndrom includ sever depress seem increas risk cardiovascular diseas associ chronic abus contrast high dosag androgen abus androgen therapi near physiolog dosag general safe effect male hypogonad potenti use sarcopenia male hormon contracept
D045930;D004300
T121;T039;T052
36,309,420
learn testosteron trial men age serum concentr total testosteron decreas slight concentr sex hormon bind globulin increas concentr free testosteron decreas greater degre testosteron trial demonstr testosteron treatment elder men low serum testosteron level increas sexual function hemoglobin bone miner densiti moder degre walk vital mood slight testosteron treatment increas coronari arteri noncalcifi plaqu volum howev trial larg enough long enough know testosteron treatment increas clinic heart diseas prostat diseas
D013739;D007006
T125;T121;T047;T109
36,309,419
testosteron male sexual function articl review role testosteron normal male sexual anatom develop function consequ low testosteron sexual function clinic standard health care provid treat hypogonad men sexual dysfunct
D007172;D012735
T047;T046
36,309,418
molecular mechan castrat resist prostat cancer despit newer therapi castrat resist prostat cancer crpc mani patient experi treatment respons eventu experi secondari resist various androgen receptor relat altern mechan resist crpc identifi focus understand molecular basi therapeut resist includ lineag plastic neuroendocrin transform rang implic genom alter hope inform decis make care lethal cancer
D064129
T191
36,309,417
testosteron androgen receptor testosteron steroid hormon respons develop normal male sexual characterist function well mainten homeostasi among multipl organ system throughout life testosteron product regul hypothalam pituitari axi direct gonadotropin releas hormon lutein hormon testosteron bound androgen receptor ar potent regul gene express may regul signific proport gene prostat cell therapeut modul testosteron level ar signal activ achiev sever differ approach distinct consequ side effect
D013739;D011944
T121;T116;T192;T109;T125
36,309,416
benefit risk testosteron treatment older men hypogonad total free testosteron level declin men advanc age due defect level hypothalam pituitari testicular axi testosteron treatment older men low testosteron level associ improv sexual activ sexual desir erectil function lean bodi mass muscl strength stair climb power self report mobil areal volumetr bone miner densiti estim bone strength depress symptom anemia long term risk cardiovascular event prostat cancer testosteron treatment remain unknown testosteron treatment may offer individu basi older men unequivoc low testosteron level symptom condit associ testosteron defici consider potenti benefit risk burden symptom patient valu
D007006;D011471
T047;T191
36,309,415
current manag controversi surround andropaus andropaus condit surround controversi whether diagnosi manag learn pathophysiolog hypogonad perspect risk benefit testosteron therapi shift attempt discuss modern relev point controversi current affect field throughout review discuss art diagnos hypogonad well associ lack thereof testosteron replac therapi cardiovascular diseas prostat cancer thrombosi antiag effect exogen steroid abus diabet mellitus
D047649;D007006;D011471
T033;T047;T191
36,309,414
testosteron therapi prostat cancer incorpor low level evid practic recommend wide accept absolut contraind administr testosteron hypogonad men prostat cancer question although recommend profession associ still adher tradit concept increas relax posit current evid definit guidelin unavail clinician reli incomplet best attain inform certain circumst success treat prostat cancer activ surveil low risk diseas testosteron administr warrant intermedi high risk cancer extrem caution seem advis benefit must heavili outweigh hazard ideal men particip clinic trial registri compet initi assess individu circumst follow mandatori
D011471;D007006
T047;T191
36,309,413
inexor march prostat cancer research testosteron beyond histori prostat cancer treatment fill progress past year understand role testosteron genesi prostat cancer continu evolv diagnost test treatment local metastat prostat cancer undergon major chang recent decad transform outlook patient prostat cancer articl review major mileston prostat cancer research impact clinic care
D013739;D011471
T125;T121;T191;T109
36,309,410
associ fibromyalgia syndrom clinic sever bodi composit princip compon analysi type bodi composit modul sever musculoskelet condit fibromyalgia syndrom fms type associ remain relat unexplor
D005356
T047
36,309,409
real world effect safeti jak inhibitor rheumatoid arthriti singl centr studi assess effect safeti baricitinib tofacitinib rheumatoid arthriti ra patient real world condit
D000075242;D018501;D001172
T121;T047
36,309,406
poor prognosi intraves bacillus calmett gurin histori photodynam diagnosi assist transurethr resect use aminolevulin acid diagnost efficaci treatment outcom oral administ aminolevulin acid ala assess photodynam diagnosi pdd transurethr resect non muscl invas bladder cancer nmibc clinic practic
D000622;D001749
T123;T121;T116;T109;T191
36,309,405
effect underwat exercis salivari metabolit older person disabl underwat exercis aim prevent age maintain improv motor function improv physic function howev rehabilit effect well evalu order gain insight molecular basi rehabilit effect possibl chang salivari metabolit four older person disabl mean age year underwat exercis investig
D006209;D006233
T184;T101
36,309,404
circul chlamydia trachomati antigen subject alzheim diseas chlamydia pneumonia c pneumonia implic pathogenesi alzheim diseas ad chlamydi elementari reticul bodi identifi tissu afflict ad brain region electron immunoelectron microscopi wherea similar test non ad brain negat bacterium studi mice shown c pneumonia rapid penetr central nervous system enter glia caus beta amyloid deposit via nerv nasal caviti brain serv invas pathway
D002690;D000544
T047;T048
36,309,403
earli palliat care improv overal surviv patient lymphoma singl institut retrospect studi earli palliat care epc intervent patient solid tumor provid mani benefit howev studi patient hematolog malign limit data patient lymphoma conduct preliminari retrospect survey palliat care pc intervent patient lymphoma clarifi effect epc overal surviv os
D009369;D008223
T191
36,309,402
membran activ immunomodul novel therapi infecti bacteri diseas buruli ulcer mycobacterium ulceran caus necrot skin diseas buruli ulcer bu character format subcutan lesion immunosuppress thought mediat virul factor mycolacton sinc earli bu lesion typic painless patient often seek standard oral antibiot therapi advanc stage treatment less effect given current curat topic treatment bu object evalu plasma membran fluidize diethyl azel dea potenti novel topic therapi bu
D054312;D019911
T047;T007
36,309,401
chase hippo implic yap taz express pregnanc associ breast cancer tumorigenesi hippo pathway molecular pathway recent associ tumorigenesi metastasi drug resist pregnanc associ breast cancer pabc common malign diagnos gestat howev molecular mechan under pabc larg unknown aim present studi evalu hippo pathway transduc taz yap express pabc relat clinicopatholog characterist diseas
D048868;D001943
T123;T191;T116
36,309,400
complet respons nivolumab resect adenocarcinoma nos parotid gland origin lung metastasi salivari gland adenocarcinoma otherwis specifi nos classifi classif head neck tumor malign neoplasm without histolog featur characterist cancer type japan nation health insur program began cover nivolumab march treatment patient recurr metastat head neck cancer includ salivari gland carcinoma previous treat platinum agent exist literatur includ case patient salivari gland carcinoma adenocarcinoma nos otherwis achiev complet respons nivolumab
D000230;D012468;D008175;D006258
T191
36,309,399
three dimension laparoscopi lc versus minilaparotomi mc cholecystectomi prospect random studi three dimension laparoscopi lap recent innov surgeri lap rare use cholecystectomi lc prospect studi assess advantag disadvantag lc versus minilaparotomi mc cholecystectomi
D017081;D010535
T061;T060
36,309,398
interferon gamma releas assay result reliabl screen latent tuberculosi antineutrophil cytoplasm antibodi associ vascul studi investig correl ex vivo interferon gamma ifn gamma product use ifn gamma releas assay igra antineutrophil cytoplasm antibodi associ vascul aav activ assess birmingham vascul activ score bvas aav patient
D055985;D056648
T047
36,309,397
clinicopatholog prognost factor determin outcom treatment gastric cancer surgeri purpos studi examin impact clinicopatholog prognost factor tumor resect periop complic year surviv rate patient gastric cancer treat surgic
D013274
T191
36,309,396
effect methylsulfonylmethan uvb induc skin damag experiment studi mous model skin protect bodi ultraviolet ray extern factor various studi conduct identifi method prevent skin age damag investig protect effect methylsulfonylmethan msm studi hairless mous model use
D014466;D015595
T033;T070;T042
36,309,395
prospect studi regard efficaci safeti bntb vaccin patient solid malign undergo system chemotherapi prospect evalu efficaci safeti bntb vaccin solid cancer patient undergo system chemotherapi n
D000086382;D009369;D014612
T121;T129;T116;T067;T191;T047
36,309,394
profit analysi minim invas approach surgic treatment spinal burst fractur regard surgic treatment incomplet burst fractur spine optim standard procedur establish previous studi focus radiolog surgic outcom paramet literatur elucid econom aspect various surgic treatment option detail yet studi aim investig whether open minim invas approach differ econom profit gain furthermor examin whether singl stage two stage approach anterior posterior fusion profit
D016103;D018460
T037
36,309,393
factor predict wors outcom asian cohort patient bronchiectasi bronchiectasi long neglect unlik chronic obstruct pulmonari diseas copd asthma recent clinic trial shown long term use azithromycin erythromycin reduc exacerb non cystic fibrosi non cf bronchiectasi activ tri treat patient suscept sever status
D001987;D029424
T047
36,309,392
balneotherapi complementari non pharmacolog approach non inflammatori complaint system lupus erythematosus pilot studi despit remiss low diseas activ non inflammatori complaint like exhaust fatigu pain persist signific proport patient system lupus erythematosus sle consider impact health relat qualiti life studi evalu effect balneotherapi non inflammatori complaint qualiti life work product patient sle
D008180;D001452
T061;T047
36,309,391
ca reduct month treatment prognost factor local advanc pancreat cancer carbohydr antigen ca level may aid determin subsequ treatment patient unresect local advanc pancreat cancer lapc treat chemotherapi howev relationship time magnitud ca chang clinic outcom remain unclear studi conduct identifi time magnitud ca chang strong associ outcom lapc patient
D018395;D010190
T129;T191;T109
36,309,390
primari osteosarcoma patient year age case seri literatur review littl known clinic characterist older patient year age primari osteosarcoma due rariti aim understand clinic characterist patient order make appropri diagnosi provid treatment
D012516;D001859
T191
36,309,389
barthel index predict postop complic elder patient undergo abdomin surgeri prospect singl center studi barthel index katz index use assess physic function status patient prospect evalu relationship barthel katz indic postop complic older patient undergo gastrointestin surgeri
D011183
T046
36,309,388
fc receptor express prognost factor patient non small cell lung cancer neonat fc receptor fcrn major histocompat class like molecul respons transfer passiv humor immun mother newborn recent research reveal fcrn involv antigen present humor immun antitumor immun various type cancer lung colon breast lung cancer lead caus cancer relat death non small cell lung cancer nsclc account lung cancer nsclc high heterogen diseas affect prognosi therefor mani studi tri identifi factor associ prognosi lung major organ express fcrn aim evalu fcrn express surgic specimen nsclc determin correl patient prognosi
D002289;D008175
T191
36,309,387
chloroquin combin rapamycin arrest tumor growth patient deriv orthotop xenograft pdox mous model dedifferenti liposarcoma dedifferenti liposarcoma ddls type soft tissu sarcoma poor prognosi due distant metastasi resist chemotherapi antimalari drug chloroquin cq induc apoptosi cancer cell cq combin rapamycin rapa mtor inhibitor shown efficaci osteosarcoma type cancer present studi efficaci rapa combin cq treatment ddls patient deriv orthotop xenograft pdox model investig
D001859;D002738;D008080;D012509;D020123
T121;T191;T195;T109
36,309,386
studi therapeut effect losartan sarcopenia base fxbn rat age model sarcopenia age relat diseas muscl mass strength mark reduc effect treatment angiotensin ii receptor antagonist losartan report effect aim evalu therapeut effect losartan sarcopenia explor under mechan
D055948;D009135
T047
36,309,385
high express pregnanc specif beta glycoprotein associ poor gastric cancer prognosi pregnanc specif beta glycoprotein psg member immunoglobulin superfamili associ carcinoembryon antigen report high express varieti cancer howev role psg gastric cancer remain unclear aim studi examin clinic signific function role psg gastric cancer
D013274
T191
36,309,384
select bodi composit paramet analysi base bioelectr imped patient oper gastrointestin cancer bioelectr imped analysi method evalu bodi composit use assess nutrit status cancer patient analysi indic may help predict clinic cours aim studi evalu follow bodi composit paramet fat mass fm fat free mass ffm skelet muscl mass smm muscl mass index mmi viscer fat vf bodi mass index bmi measur surgeri patient gastrointestin cancer determin relationship bodi composit cours treatment
D001823;D005770
T032;T191
36,309,383
surviv analysi use covid death mean imput codmi algorithm first clinic applic radiat oncolog report long term surviv result trimod approach local advanc rectal cancer larc covid era herein illustr clinic applic covid death mean imput codmi algorithm larc patient covid infect
D018787;D000086382
T047;T091;T067