PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,673,310 | prosod deficit interperson difficulti patient schizophrenia present studi examin use recept emot linguist prosodi patient schizophrenia particular aim evalu type number error made comprehend emot mode impli meaningless utter seventi eight particip enrol studi ie two group patient schizophrenia healthi control consist subject sever ill evalu posit negat syndrom scale comprehens emot linguist prosodi assess subtest polish version right hemispher languag batteri neither emot linguist prosodi comprehens correl schizophrenia symptom studi group experienc difficulti distinguish happi anger like misunderstand imper utter confus interrog affirm one impair signific may affect abil form sustain relationship peopl achiev success work environ integr communiti may also trait mark ill independ psychot symptom research need translat knowledg meaning therapeut intervent improv qualiti life affect individu communic partner | D012559 | T048 |
34,673,309 | two data driven approach identifi spectrum problemat opioid use pilot studi within chronic pain cohort although electron health record ehr signific potenti studi opioid use disord oud detect oud clinic data challeng model use ehr data predict oud often reli casecontrol classif focus extrem opioid use need expand work character spectrum problemat opioid use | D059350;D009293 | T048;T047;T184 |
34,673,308 | develop implement clinic decis support base initi drive intraven fluid prescrib studi suggest superior outcom use intraven iv balanc fluid compar normal salin ns howev signific fluid prescrib variabl persist highlight knowledg practic gap sought identifi contributor prescrib variat util clinic decis support system cdss increas institut balanc fluid prescrib | D020000;D050316 | T058;T170;T073 |
34,673,307 | de novo assembl annot whole transcriptom muraenesox cinereus studi generat transcriptom muraenesox cinereus four combin tissu muscl sexual liver heart use high seq sequenc technolog de novo assembl perform use triniti softwar total high qualiti clean read assembl cluster unigen n nt annot unigen signific hit nr databas unigen annot three go categori biolog process cellular compon molecular function moreov unigen map differ cluster eukaryot protein furthermor predict structur unigen use hmmer misa softwar respect result show total nucleotid sequenc code region direct sequenc confirm protein databas total simpl sequenc repeat ssr identifi whole transcriptom import foundat futur genom research cinereus could provid comprehens understand character transcriptom non model organ | D018895;D059467 | T086;T081;T114;T123 |
34,673,306 | interact poloxam peox ppoy peox non ionic surfact sucros monolaur studi potenti allergen effect use model phospholipid membran sugar base surfact involv skin relat allergi case past decad skin irrit start interact surfact skin lipid lead lipid emulsif eventu barrier damag polym co surfact use mitig allergen effect mechan formul mild skin remain unclear use quartz crystal microbal qcm togeth dissip particl dynam dpd simul small angl x ray scatter sax well cell viabil test deciph interact poloxam sucros monolaur sml interact could prevent disrupt model support phospholipid bilay slb poloxam addit sml solut delay total prevent disrupt slb depend poloxam type concentr poloxam p pluron f delay onset disrupt poloxam p pluron f preserv bilay integr even high concentr ww preserv slb like due differ aggreg format sml f sml f mixtur correspond retard motion sml micell sml f polym matrix improv cell viabil | D020442;D013501 | T120;T121;T122;T109 |
34,673,305 | combin apatinib tran arteri chemotherapi embol convers therapi unresect local advanc gastric cancer convers therapi promis option unresect local advanc gastric cancer gc patient studi aim investig feasibl efficaci convers therapi base apatinib combin transarteri chemotherapi embol tace | D013274 | T191 |
34,673,304 | model inciner accur comparison recycl pef lca recycl benefici environ result life cycl assess lca give incent collect recycl also use recycl materi new product mani approach model recycl lca assign part environment benefit recycl product recycl materi use exampl circular footprint formula framework product environment footprint pef assign less benefit recycl polym product sent recycl calcul indic creat incorrect climat incent inciner renew ldpe recov energi substitut energi sourc climat impact swedish averag district heat electr risk incorrect incent reduc alloc part net benefit energi recoveri life cycl energi use propos part sweden probabl less countri without district heat network altern lca includ altern treatment wast displac inciner wast investig product solut make lca balanc consist alloc factor inciner almost elimin risk incorrect incent pef renew polym howev focus lca one product time might still make insuffici guid recycl requir concert action actor differ life cycl | D012037;D018505 | T057;T068 |
34,673,303 | gfht propos practic use argatroban specif regard vaccin induc immun thrombot thrombocytopaenia vitt argatroban direct anti iia thrombin anticoagul administ continu intraven infus approv mani countri anticoagul manag heparin induc thrombocytopaenia hit argatroban recent propos non heparin anticoagul choic manag patient diagnos vaccin induc immun thrombot thrombocytopaenia vitt immunoglobulin also prompt intraven administ order rapid improv platelet count concomit therapi steroid also often consid ad hoc committe french work group haemostasi thrombosi member work updat detail propos regard manag anticoagul argatroban base previous releas guidanc hit adapt vitt case vitt initi dose prefer g kg min dose adjust base iter frequent clinic laboratori assess strong advis involv health practition experienc manag difficult case haemostasi first laboratori assess perform h initi argatroban infus control h interv steadi state least daili thereaft import full anticoagul rapid achiev case widespread thrombosi cerebr vein thrombosi typic vitt call over cautious anticoagul scheme argatroban administr requir baselin laboratori assess reli anti iia assay deriv argatroban plasma level use dedic calibr target rang gml target argatroban plasma level refin base meticul apprais risk factor bleed thrombosi frequent reassess clinic status appropri vascular imag chang daili platelet count regard use aptt baselin valu possibl caus alter clot time must taken account specif case vitt aptt ratio patientsmean normal clot time suggest refin accord sensit reagent effect direct thrombin inhibitor sole use aptt discourag one resort period check anti iia assay least help specialis laboratori necessari dose modif proceed stepwis manner g kg min downward chang take account initi dose laboratori result whole individu set nomogram avail adjust infus rate haemoglobin level platelet count fibrinogen plasma level liver test period check depend clinic status unstabl | D013921;D013927;D014612 | T116;T047;T121;T129;T046 |
34,673,302 | select balanc contrast valu proxim prime multitarget forag task critic question visual forag concern mechan drive next target select observ first identifi set candid target select best option among candid recent evid suggest target select reli intern bias toward proxim nearest target last select prime target categori last select valu target associ high valu test role eye movement target select notabl whether disabl eye movement target select could affect search strategi ask observ perform four forag task differ select modal target valu gaze forag particip accur fixat target select could anticip next select eye mous forag select target mous click free move eye moreov manipul target valu proxim result reveal notabl individu differ search strategi confirm exist intern bias toward valu proxim prime critic differ search strategi mous gaze forag suggest disabl eye movement target select affect forag behaviour result import suggest overt orient necessari target select studi provid fundament inform theoret concept attent select emphas import covert attent target select visual forag | D001288;D005133 | T039;T041 |
34,673,301 | role mechan knowledg singular causat judgment singular causat queri eg mari take contracept caus thrombosi ubiquit everyday life crucial mani profession disciplin medicin law knowledg general causal regular necessari suffici establish singular causat relat possibl co occurr consist known regular individu case still coincident thus cue help establish singular causat relat present research focus inform mechan potent cue previous studi shown reason consid mechan inform import come answer singular causat queri formal model propos explain case present comput model explain causal mechan inform affect singular causat judgment also use model identifi condit restrict util mechan inform report three experi test implic formal analysi experi found reason systemat use mechan inform larg accord formal model although also discov peopl seem reli simpler comput less demand reason strategi result experi demonstr reason tentat understand condit restrict util causal mechan inform | D007600;D011340 | T041 |
34,673,294 | moder freshwat fish intak n polyunsatur fatti acid associ reduc risk small gestat age prospect cohort chines pregnant women although previous studi found matern fish intak associ fetal growth role freshwat fish intak remain unknown | D015525;D037841 | T098;T121;T109;T123 |
34,673,292 | cerebr represent sequenc pattern across multipl present format abil detect abstract pattern under tempor sequenc event crucial mani human activ includ languag mathemat cortic correl remain poor understood also unclear whether repeat exposur sequenc sensori stimuli suffici induc encod abstract amod represent pattern use function mri probe exist abstract code sequenti pattern local human brain relat exist languag math respons network use passiv sequenc violat paradigm given sequenc repeat present rare deviant sequenc introduc present two binari pattern aabb abab four present format either visual auditori either cu ident stimuli spatial locat regardless present format habitu repeat pattern respons pattern violat seen set inferior frontal intrapariet tempor area within languag area pattern violat respons found inferior frontal gyrus ifg wherea math respons region respond pattern chang region also respond whenev modal cue chang suggest general sensit violat detect thus represent sequenc pattern appear distribut yet includ core set abstract amod region particular ifg | D001931;D008279 | T062;T170;T059;T060 |
34,673,291 | reclassifi stroke lesion anatomi cognit behaviour outcom stroke reflect interact two complex anatom distribut pattern function organ brain structur distribut ischaem injuri convent outcom model individu predict popul level infer common ignor complex discard anatom variat beyond simpl characterist lesion volum set hard limit maximum fidel model achiev high dimension method overcom problem prohibit larg data scale draw one largest publish collect anatom regist imag acut stroke n use non linear dimension reduct deriv succinct latent represent anatom pattern ischaem injuri agglomer distinct intuit categori compar maxim predict perform enabl simpler low dimension complex high dimension represent employ multipl empir inform ground truth model distribut structur outcom relationship show represent set substanti higher ceil predict fidel convent low dimension approach lower achiev within high dimension framework descript simplic necess within clinic care research trial modest size represent propos arguabl offer favour compromis compact fidel | D020521 | T047 |
34,673,290 | compar efficaci strategi support self manag patient asthma systemat review network meta analysi limit evid composit featur asthma self manag strategi best adopt practic | D001249;D000073278 | T058;T047 |
34,673,287 | preval manag anaphylaxi risk cold urticaria systemat review meta analysi cold urticaria subtyp chronic induc urticaria cindu associ signific morbid risk anaphylaxi studi assess preval manag preval associ anaphylaxi cold urticaria | D000707;D000080223;D014581 | T047;T046 |
34,673,286 | nebul use black latinx adult moder sever asthma general short act beta agonist saba deliv via meter dose inhal mdi recommend quick relief asthma symptom howev person empow asthma relief prepar pragmat trial patient report use nebul saba administr | D001249;D009330 | T074;T047 |
34,673,279 | dynam alter blood flow glaucoma measur laser speckl contrast imag assess repeat blood flow veloc index bfvi metric obtain recent food drug administr clear laser speckl contrast imag devic xycam ri vasopt medic inc character differ metric among control glaucoma suspect glaucoma particip | D005901;D009798 | T047 |
34,673,278 | beyond elect rethink train global neurolog global health elect neurolog resid provid opportun high incom countri traine limit benefit may creat burden lower incom countri host current suspens global health elect us neurolog resid due covid pandem provid opportun reflect way reimagin global health educ period beyond framework propos articl underscor need equit bidirect intern partnership highlight global health educ innov develop pandem | D000086382;D007396;D009462 | T065;T047;T097;T091;T067 |
34,673,277 | gut microbi metabolit tmao increas periton inflamm periton risk periton dialysi patient trimethylamin n oxid tmao gut microbiota produc metabolit accumul chronic kidney diseas ckd patient well known contribut ckd relat cardiovascular complic howev effect tmao periton dialysi pd relat periton remain larg unknown demonstr serum concentr tmao posit correl c reactiv protein level appear rate dialys il pai pd patient follow period month patient higher tmao level higher risk new onset periton hr ci p adjust sex age diabet pd durat bun rgfr c reactiv protein bmi ckd rat model tmao signific promot periton dialys induc inflammatori cell infiltr inflammatori cytokin product peritoneum vitro studi reveal tmao direct induc primari periton mesotheli cell necrosi togeth increas product pro inflammatori cytokin includ ccl tnf il il addit tmao signific increas tnf induc p selectin product mesotheli cell well high glucos induc tnf ccl express endotheli cell conclus data demonstr higher level tmao exacerb periton inflamm might risk factor incid periton pd patient | D000069196;D055442 | T070;T007;T039;T001 |
34,673,276 | arthroplasti trapeziometacarp joint without bioabsorb polylactid scaffold regjoint interposit regjoint bioabsorb polylactid scaffold introduc scaphometacarp interposit follow trapeziectomi osteoarthr previous clinic trial provid controversi result aim prove non inferior regjoint interposit retrospect studi first metacarp suspens arthroplasti alon sa compar suspens regjoint interposit rj thirti four patient treat thumb sa rj assess clinic radiolog mean follow year sa rj patient report outcom measur three questionnair dash prwe pem visual analogu pain scale signific differ group clinic assess compris rang motion opposit pain first ray length hand span promin instabl forc sensit touch rj group show signific better palmar abduct p outcom paramet compar group follow radiograph show osteolysi sa hand rj hand p first ray length decreas mean mm follow sa rj p sign advers tissu reaction observ conclud regjoint spacer produc complic suspens alon provid ad benefit | D020341;D051222 | T023;T074 |
34,673,275 | stereotact radiosurgeri postop spine malign systemat review intern stereotact radiosurgeri societi practic guidelin determin safeti efficaci postop spine stereotact bodi radiat therapi sbrt publish literatur present practic recommend behalf intern stereotact radiosurgeri societi | D050815;D016634;D016103;D013125 | T037;T191;T046;T061 |
34,673,274 | gene edit enhanc efficaci cancer cell therapi adopt cell therapi shown impress signal activ clinic impact could enhanc technolog increas cell potenc diminish cost labor involv manufactur product gene edit platform studi arena enhanc immun cell potenc knock molecul inhibit immun respons deliv genet payload precis genom locat therebi enhanc safeti andor improv gene express profil leverag physiolog promot enhanc repressor enabl shelf therapi prevent alloreact immun reject review discuss gene edit approach best studi context human cell adopt cell therapi summar current status near term potenti translat | D064987;D000072669;D015316 | T063;T061 |
34,673,273 | prostat cancer clinic trial complet role geographi one five cancer clinic trial fail anoth third fail meet enrol goal prior effort improv enrol focus patient face intervent geograph factor region cancer incid may doom trial even begin reason examin associ region prostat cancer incid trial termin identifi scientif underserv area futur trial might thrive | D011471 | T191 |
34,673,272 | hysteroscop treatment assist photodynam diagnosi atyp polypoid adenomyoma report two case atyp polypoid adenomyoma apa intrauterin tumor hysteroscop tumor resect allow fertil preserv complet resect import high recurr rate apa difficult due lack characterist hysteroscop find previous report case photodynam diagnosi pdd use detect apa report two addit case apa treat hysteroscop resect pdd procedur approv ethic committe case year old femal underw hysteroscop surgeri submucos tumor suspect apa hypermenorrhea case year old femal hysteroscop surgeri perform residu apa lesion hormon therapi case pdd identifi tumor border enabl complet resect possibl case lesion could identifi clear white light area pdd posit excis among specimen two case previous report case pdd posit specimen patholog diagnos apa sensit specif pdd apa respect result suggest pdd contribut identif apa | D018194;D059247;D010778;D014594 | T191;T061 |
34,673,271 | alter choroid microvasculatur determin optic coher tomographi angiographi patient acromegali aim investig retin layer macular capillari structur use optic coher tomographi angiographi octa acromegali patient determin relationship octa paramet diseas durat growth hormon gh insulin growth factor igf level | D000172;D010778 | T047;T061 |
34,673,270 | role riboflavin curcumin photosensit ozon use canal disinfect push bond strength glass fiber post radicular dentin assess efficaci photosensit cp riboflavin gaseous ozon comparison convent radicular dentin disinfect naocl push bond strength pbs pfrc post cement radicular dentin | D003474;D004202;D010126;D010778 | T121;T109;T130;T167;T131;T103;T061 |
34,673,269 | shear bond strength resin modifi glass ionom cement follow photodynam therapi er cr ysgg chlorhexidin hypoplast primari teeth studi investig micro shear bond strength resin modifi glass ionom cement rmgic bond hypoplast teeth applic chlorhexidin chx sodium hypochlorit naocl er cr ysgg methylen blue mediat antimicrobi photodynam therapi apdt | D053844;D010778 | T061;T074;T073 |
34,673,268 | proteom reveal gender differ physiolog characterist gonad tube feet sea cucumb apostichopus japonicus sea cucumb apostichopus japonicus import aquacultur speci china high nutrit medicin valu gender factor affect physiolog organ alway consid improv breed effici econom import anim present studi protein express profil gonad tube feet male femal japonicus investig use compar proteom approach set protein identifi cover broad rang function base function annot signific differ protein express profil observ gonad tube feet japonicus gonad show appar gender differ tube feet moreov find reveal male japonicus specif function function associ energi consumpt analys suggest regul erk activ capac tyrosin product virus immun might power male femal japonicus respect candid protein also recogn potenti target gender identif japonicus overal studi provid new insight understand molecular mechan under gender base physiolog differ japonicus signific current studi aim reveal gender differ physiolog characterist gonad tube feet sea cucumb japonicus best knowledg first proteom studi analyz differ protein express profil extern organ male femal japonicus analysi reveal gender differ protein express profil gonad tube feet japonicus gender differ gonad quit appar moreov accord recognit differenti express protein enrich analys base kyoto encyclopedia gene genom draft view physiolog function japonicus affect gender obtain male japonicus could specif function relat energi consumpt femal regul erk activ virus immun might robust male femal japonicus respect candid protein also recogn potenti target gender identif japonicus find present improv understand research molecular mechan under gender base differ japonicus contribut meticul breed japonicus | D012616;D047528 | T204 |
34,673,267 | gluten protein enzymat modif function therapeut properti gluten potenti protein multifunct therapeut effect coval network structur without proteas inhibitor expect enhanc serv properti technolog point increas bioactiv surfac gelatin gelat past properti deplet allerg peptid sequenc gluten protein compris sometim proteas inhibitor valid via enzymat ingest use proteolyt enzym might enhanc function technolog process produc activ peptid osmoregul regular glass transit surfac activ coat encapsul properti addit therapeut function immunoregulatori antithrombin opioid activ particular erad free radic suppress diabet mellitus ii complic inhibit angiotensin convert enzym cardiovascular growth diseas | D005983;D010447 | T116;T121;T126;T123 |
34,673,266 | treatment knee sprain children incid knee sprain children steadili increas skelet immatur anatom featur child ligament structur explain frequenc bone avuls young children peripher ligament injuri common often benign nevertheless associ injuri cruciat patellofemor ligament rare must miss age determin factor diagnost guidanc anterior intercondylar tibial emin fractur otherwis known tibial spine fractur tsf usual occur young children ligament distens time accid would explain residu laxiti affect prognosi fractur treatment interstiti ruptur acl follow recommend becom clearer multicentr studi repar techniqu histor reject ineffect becom topic specif condit aim preserv nativ acl propriocept receptor essenti children acl reconstruct techniqu made progress children especi techniqu adapt adult preserv growth plate remain pertin especi femur avoid growth disord thus highlight import role paediatr orthopaed surgeon manag knee sprain | D000070598;D059549;D001168;D007718;D017695;D013180;D013978 | T061;T047;T037 |
34,673,265 | go catalogu human dna bind transcript factor control gene transcript dna bind transcript factor recognis specif sequenc motif gene regulatori region complet reliabl go annot dna bind transcript factor key investig delic balanc gene regul respons environment development stimuli need inform demonstr mani list transcript factor produc past decad cost action gene regul ensembl effort knowledg common greekc consortium brought togeth expert field transcript aim provid high qualiti interoper gene regulatori data gene ontolog go consortium provid strict definit gene product function includ factor regul transcript collabor greekc go consortia enabl applic definit produc new curat catalogu human dna bind transcript factor access https wwwebiacukquickgotargetsetdbtf catalogu facilit improv go annot human dna bind transcript factor led go annot almost sixti thousand dna bind transcript factor hundr speci thus work aid research investig regul transcript biomed basic scienc | D063990;D058977 | T062;T170;T063 |
34,673,262 | current research status blood biomark alzheim diseas diagnosi prognosi alzheim diseas ad main occur elder neurodegen diseas hidden onset lead progress cognit behavior chang annual increas preval rate number patient ad exert great pressur societi effect diseas modifi drug treatment avail thus cure yet diseas progress delay earli detect drug assist therefor import explor associ biomark earli diagnosi predict diseas progress highlight nation institut age alzheim associ nia aa propos atn diagnost criteria includ p tau tau cerebrospin fluid csf positron emiss tomographi pet howev invas lumbar punctur csf assess non popular pet prompt research look minim invas easi collect cost effect biomark therefor studi larg focus novel molecul peripher blood emerg research field face mani obstacl challeng achiev promis result | D000544;D019636 | T048;T047 |
34,673,261 | caution underrepresent older adult clinic trial covid vaccin read great interest articl underrepresent older adult clinic trial covid vaccin systemat review written nicola verones et al import work demonstr medic vaccin common use older adult adequ evalu concern systemat review shall like mention certain point deserv attend author | D000086382;D014612 | T116;T047;T121;T129;T067 |
34,673,259 | increas migrain free interv multifoc repetit transcrani magnet stimul episod migrain debilit condit associ vast impair health daili live life qualiti sever prophylact treatment exist moder ratio action relat side effect therapi cost repetit transcrani magnet stimul rtms evid base therapi sever neuropsychiatr condit show robust efficaci allevi specif symptom howev efficaci migrain disord unequivoc might tight link appli rtms protocol hypothes multifoc rtms paradigm could improv clinic outcom patient episod migrain reduc number migrain day frequenc intens migrain attack improv qualiti life | D008881;D050781 | T062;T047;T061 |
34,673,258 | pair acut invasivenon invas stimul pain studi phase iii random sham control crossov trial chronic neuropath pain dorsal root ganglion drg stimul invas method neuromodul transcrani direct current stimul tdcs non invas method alter cortic excit proven effect reliev chronic pain | D059350;D009437;D065908 | T047;T184;T061 |
34,673,256 | efficaci test immers vaccin aeromona salmonicida immunocompet ballan wrass labrus bergylta ascanius develop effect vaccin critic step toward domest emerg fish speci aquacultur howev tradit vaccin deliveri intraperiton ip inject requir fish reach minimum size age therefor provid protect earli development stage infect may occur studi investig effect immers vaccin respect immunocompet cleaner fish speci ballan wrass labrus bergylta ascanius use atlant salmon farm altern mean control sea lice speci suscept atyp strain aeromona salmonicida aa earli life stage g hatcheri | D048409;D001428;D005393;D010473 | T007;T047;T121;T129;T013 |
34,673,252 | chemic induc model parkinson diseas environment toxin harm substanc detriment human constant exposur fatal neurotoxin caus various neurodegen disord although poison specif neurotoxin optim concentr mimic clinic featur neurodegen diseas sever anim model chemic induc model system benefici deciph molecular mechan neurodegener drug screen disord one neurotoxin methyl phenyl tetrahydropyridin mptp wide use chemic recapitul parkinsonian featur various anim model apart mptp neurotoxin like hydroxydopamin ohda paraquat rotenon also induc specif clinic featur parkinson diseas anim model chemic induc parkinson diseas model play crucial role understand parkinson diseas onset patholog novel therapeut review provid concis overview various neurotoxin recapitul parkinsonian featur differ vivo vitro model system specif focus differ treatment methodolog neurotoxin | D004195;D010302 | T047;T050 |
34,673,250 | antiparasit potenti ethanol extract carpesii fructus miamiensi avidus hiram natur embryo cell line effect immun respons biotransform relat gene scuticociliatosi caus miamiensi avidus sever parasit diseas affect marin organ particular paralichthi olivaceus aim studi assess antiparasit potenti ethanol extract carpesii fructus eecf dri fruit carpesium abrotanoid l use tradit chines medicin vitro found eecf induc morpholog chang avidus includ reduc motil cell shrinkag lysi near cell lysi observ avidus h treat eecf h surviv rate avidus treat eecf respect addit mrna level immun respons relat il il tnf cd biotransform relat cypa cypb cypa ugtb gene increas eecf treatment decreas eecf treatment follow pretreat concanavalin viabil hiram natur embryo hina cell reduc eecf mgl ic valu eecf hina cell mgl respect result indic eecf less toxic hina cell eecf still exhibit antiparasit activ avidus therefor demonstr role eecf natur antiparasit agent avidus find suggest carpesii fructus potenti use antiparasit agent aquacultur industri | D005393 | T047 |
34,673,248 | machin learn predict cognit function connect featur weight reliabl cognit perform predict individu function brain connect modest accuraci use machin learn approach yet howev predict model arguabl yield limit insight neurobiolog process support cognit featur select featur weight estim need reliabl ensur import connect circuit high predict util reliabl identifi comprehens investig featur weight test retest reliabl various predict model cognit perform built rest state function connect network healthi young adult n despit achiev modest predict accuraci r find featur weight reliabl general poor predict model icc signific poorer predict model overt biolog attribut sex icc larger sampl size n hauf transform non spars featur selectionregular smaller featur space margin improv reliabl icc elucid tradeoff featur weight reliabl predict accuraci find univari statist margin reliabl featur weight predict model final show measur agreement featur weight cross valid fold provid inflat estim featur weight reliabl thus recommend reliabl estim sampl possibl argu rebalanc focus predict accuraci model reliabl may facilit mechanist understand cognit machin learn approach | D000069550 | T066 |
34,673,246 | cuticl melan express immun relat gene honeybe api mellifera hymenoptera apida adult worker global declin bee popul sever factor includ pathogen need overcom insect defens physic barrier bodi cuticl peritroph matrix primari defens well secondari defens antimicrobi peptid amp enzym lysozym regul immun defens accord infect risk rais question immun social bee due exposit differ pathogen pressur adult lifespan task perform studi evalu primari bodi cuticl melan peritroph matrix cpr express secondari amp lysozym express defens honeybe api mellifera worker accord age task express malvolio use detect precoci forag task outsid coloni forag worker higher amount cuticular melan bodi cuticl nurs age effect retir indic gradual acquisit compound integu adult bee relat valu chitin peritroph matrix cpr mrna similar bee evalu suggest compon primari defens chang accord task age differenti express gene amp worker perform differ task within age group indic behavior stimul express gene relat secondari immun defens express malvolio gene acceler chang worker behavior relat immun defens suggest invest secondari defens mechan primari defens bodi cuticl yet complet | D006927 | T204 |
34,673,244 | intern mix realiti immers experi approach via surgic grand round coronavirus diseas creat unintend signific experienti barrier surgic learner interact bedsid teachingcas present hypothes intern grand round use microsoft hololen extend realiti xr headset would creat improv bedsid learn experi compar tradit grand round format | D000081411;D007391;D056164;D000076142 | T065;T066;T064;T170;T058 |
34,673,237 | stepwis increas thaxtomin product streptomyc albidoflavus j combinatori metabol engin herbicid resist weed becom serious threat agricultur across world thus urgent need discoveri develop herbicid new mode action thaxtomin phytotoxin group nitrat diketopiperazin produc potato common scab caus phytopathogen streptomyc scabi actinobacteri pathogen general consid function inhibitor cellulos synthesi plant thus great potenti use natur herbicid generat overproduc strain crucial scale product thaxtomin wide use agricultur present studi employ stepwis strategi combin heterolog express repressor delet activ overexpress optim ferment media high level product thaxtomin maximum yield mgl thaxtomin achiev engin streptomyc albidoflavus j strain shake flask cultur approxim fold higher albidoflavus j carri unmodifi cluster moreov yield thaxtomin could reach mgl engin strain cultiv small scale stir tank bioreactor highest titer report date repres signific leap forward scale product thaxtomin studi present robust easi use system broad use improv titer bioactiv compound mani streptomyc speci | D060847;D013302 | T007;T063 |
34,673,236 | rewir cyanobacteri photosynthesi implement oxygen toler hydrogenas molecular hydrogen h consid ideal energi carrier replac fossil fuel futur biotechnolog h product driven oxygen photosynthesi appear high promis biocatalyst h synthes reli main light water co rare metal biolog process requir coupl photosynthet water oxid apparatus h produc hydrogenas howev strategi imped simultan releas oxygen strong inhibitor hydrogenas address challeng introduct toler hydrogenas phototroph bacteria name cyanobacteri model strain synechocysti sp pcc end gene cluster encod solubl toler nad h depend hydrogenas ralstonia eutropha resh function transfer synechocysti strain featur knockout nativ sensit hydrogenas intrigu photosynthet activ cell produc toler resh activ confirm vitro vivo resh enabl construct strain synresh util h sole electron sourc fix co synresh also abl produc h dark ferment condit well presenc light condit foster intracellular nadh excess find highlight high level interconnect resh cyanobacteri redox metabol studi lay foundat engin eg electron transfer resh via nadph ferredoxin final enabl photosynthesi driven h product | D006864;D046939 | T116;T007;T126 |
34,673,235 | lepidopteran mevalon pathway optim escherichia coli effici produc isoprenol analog next generat biofuel terpen constitut largest class natur product compound versatil applic includ drug biofuel introduc structur modif terpen metabol engin effici sustain way improv properti report optim lepidopteran mevalon lmva pathway toward effici product isopentenyl pyrophosph ipp analog terpen precursor first link lmva pathway nudb promiscu phosphatas result product six carbon analog methyl buten ol isoprenol ethyl buten ol c isoprenol use c isoprenol final product engin lmva pathway redirect upstream portion thiolas depend pathway beta oxid pathway beta oxid lmva pathway transform valer acid platform chemic produc biomass c isoprenol titer mgl improv mgl thiolas lmva pathway use propion acid feedstock knockout e coli endogen thiolas gene improv c isoprenol titer mgl impli effici product homo isopentenyl pyrophosph hipp beta oxid lmva nudb pathway also convert butano acid hexano acid isoprenol isoprenol seven carbon analog propyl buten ol c isoprenol respect suggest beta oxid lmva pathway produc ipp c ipp correspond fatti acid fuel properti test reveal longer chain isoprenol analog lower water solubl similar higher energi densiti compar research octan number ron boost effect isopentenol work optim lmva pathway set basi homoterpen biosynthesi expand terpen chemic space provid effici pathway produc isoprenol analog next generat biofuel sustain feedstock | D029968;D008798 | T116;T109;T123 |
34,673,234 | autophagi bone diseas autophagi ubiquit cellular process allow remov recycl damag protein organell basal level process play role qualiti control thus particip cellular homeostasi autophagi also induc various stress nutrient depriv hypoxia allow cell surviv condit improv recent year role process wide studi mani patholog neurodegen diseas cancer bone tissu various studi shown autophagi involv surviv differenti activ osteoblast osteocyt osteoclast evolut knowledg led identif new molecular pathophysiolog mechan bone patholog review report current state knowledg role autophagi bone diseas osteoporosi seem associ decreas autophagi osteopetrosi paget diseas cours autophag process disturb final osteosarcoma autophagi seem play protumor role better understand involv autophagi patholog eventu lead identif new potenti therapeut target | D001343;D010024 | T043;T047 |
34,673,233 | new case human dirofilariosi balkan peninsula mask intrud uncov surgeon dirofilaria spp nematod accident parasit human caus mild serious superfici viscer infect superfici dirofilariosi rather common europ typic manifest subcutan form herein report new case human dirofilariosi patient subcutan patient ocular patient wih genit patient submucos patient pulmonari patient intramuscular form infect record begin may balkan peninsula goal updat preval parasitosi point potenti problem diagnosi treatment besid given high possibl misinterpret tumor second aim encourag inclus pathogen differenti diagnosi subcutan nodul although quit common form subcutan ocular dirofilariosi often misdiagnos clinic practic due absenc specif clinic manifest therefor rais awar clinician zoonosi need well closer collabor physician veterinarian | D004184;D015047 | T047 |
34,673,232 | parallel select distinct tof allel drove adapt cultiv wild soybean high latitud photoperiod respons key factor limit geograph distribut cultiv soybean wild ancestor particular genet basi adapt wild soybean remain poor understood studi combin whole genom resequenc genom wide associ studi identifi novel locus time flower tof promot flower enhanc adapt high latitud wild cultiv soybean genom genet transgen analys show tof encod homolog arabidopsi thaliana fruitful ful import analys suggest differ allel tof undergon parallel select tof h allel strong select human earli domest cultiv soybean tof h allel natur select wild soybean case facilit adapt high latitud moreov found key flower repressor e suppress transcript tof bind promot turn tof physic associ promot two import flower locus ft fta fta upregul transcript promot flower long photoperiod collect find provid insight wild soybean adapt high latitud natur select indic cultiv soybean underw chang gene evolv distinct allel artifici select domest | D035264;D013025 | T168;T002 |
34,673,231 | integr approach investig age relat modif morpholog mechan structur properti type collagen main propos studi character impact chronolog age mechan structur biochem morpholog properti type collagen develop origin approach combin stress strain measur devic portabl raman spectromet enabl simultan measur raman spectra stress vs strain respons young adult adult old rat tail tendon fascicl rttfs data show increas mechan properti young modulus yield strength ultim tensil strength age molecular level raman data reveal relev frequenc shift observ cm old rttfs assign c c suggest long axi deform peptid chain old rttfs tensil stress addit intens band cm correspond hydroxyprolin decreas young adult rttfs increas adult one remain unchang old rttfs tensil stress amid iii band cm well band ratio respons tensil stress depend mechan phase toe elast plastic quantif advanc glycat end product lc msms spectrofluorometri show increas content age suggest accumul product correl alter observ mechan molecular properti rttfs analysi morpholog properti rttfs shg combin ct fire softwar reveal increas length straight collagen fiber wherea width wavi fraction decreas integr studi model could use provid addit translat inform monitor progress diseas relat collagen remodel musculoskelet disord statement signific type collagen major compon extracellular matrix architectur structur organ play import role mechan properti mani tissu physiolog patholog level object work develop integr approach bring new insight impact chronolog age structur organ mechan properti type collagen combin portabl raman spectromet mechan tensil test devic order monitor real time chang raman fingerprint type collagen fiber mechan stress raman spectroscopi allow identif type collagen bond affect mechan stress differenti manner age | D024042;D053719 | T116;T063;T123 |
34,673,230 | titanium surfac nanospik tune macrophag polar produc inhibitori factor osteoclastogenesi nanotopograph cue definit prevent inflammatori osteolysi around peri implant bone tissu remain unestablish macrophag play key role host defens inflammatori osteolysi polar depend cell shape macrophag polar control environment stimuli particular physicochem cue henc titanium nanosurfac might tune macrophag polar function studi determin whether titanium nanosurfac anisotrop pattern nanospik regul macrophag polar inhibit osteoclast differenti osteoclast precursor alkalin etch treatment differ protocol creat two type titanium nanosurfac anisotrop pattern nanospik high low distribut densiti togeth superhydrophil presenc hydroxyl group ja cell mous macrophag like cell line cultur titanium nanosurfac exhibit truli circul shape high express less marker without loss viabil like polar macrophag titanium nanosurfac independ protein mediat ligand stimul titanium surfac hydrophil chemic status contrast smooth micro roughen titanium surfac littl nanospik activ macrophag cultur condit macrophag cultur supernat titanium nanosurfac inhibit osteoclast differenti raw cell mous osteoclast precursor cell line even co incub osteoclast differenti factor inhibitori effect osteoclast differenti tend higher macrophag cultur titanium nanosurfac denser nanospik result show titanium nanosurfac anisotrop pattern nanospik tune macrophag polar inhibit osteoclast differenti osteoclast precursor nanotopograph cue rather physicochem properti statement signific peri implant inflammatori osteolysi one serious issu dental orthoped implant macrophag polar function key prevent peri implant inflammatori osteolysi macrophag polar regul biomateri surfac physicochem properti hydrophil topographi howev titanium surfac modif prevent inflammatori osteolysi immunomodul present studi show first time titanium nanosurfac anisotrop pattern nanospik creat simpl alkali etch treatment polar macrophag like type produc inhibitori factor osteoclast differenti phenomenon attribut nanotopograph cue hydrophil titanium nanosurfac nanotechnolog might pave way develop smart implant surfac prevent peri implant inflammatori osteolysi immunomodul | D010012;D014025 | T042;T196 |
34,673,229 | develop character hydrogel base adhes patch seal open globe injuri full thick wound eye lead serious vision impair current standard care sutur tissu transplant usual requir high skill surgeon use oper theater studi report synthesi optim vitro ex vivo test photocrosslink hydrogel base adhes patch easili appli globe injuri corneal incis accord type concentr polym use adhes formul abl fine tune physic properti bioadhes includ viscos elast modulus extens ultim tensil strength adhes transpar water content degrad time swellabl vitro studi show sign cytotox hydrogel moreov hydrogel patch show higher adhes fresh explant pig eyebal compar market ocular sealant final ex vivo feasibl studi show hydrogel patch could seal complex open globe injuri larg incis cruciform injuri injuri associ tissu loss result suggest photocrosslink hydrogel patch could repres promis solut seal open globe injuri surgic incis statement signific current manag sever ocular injuri requir advanc surgic skill access oper theater address need emerg manag wound handl oper room surgic adhes gain popular none current avail adhes optim bioavail adhes mechan properti studi describ develop optim test light sensit adhes patch easili appli eye solidif use visibl light patch show toxic adher tissu market sealant thus technolog could repres promis solut stabil ocular injuri emerg set definit surgic repair | D020100;D014014 | T122 |
34,673,228 | high plex express profil reveal implant drive spatiotempor protein product innat immun activ tissu repair surpris littl clariti exist concern effect biomateri properti spatial local protein express drive implant success wound heal tissu regener must optim support implant adsorb protein immun cell fibroblast cell determin repair function recoveri protein product regul howev yet fulli understood implant differenti drive spatial quantiti individu protein within implant interior tissu surround appli geomx digit spatial profil site specif investig protein product porous implant data collect locat quantiti protein formalin fix paraffin embed tissu slide anisotrop tissu scaffold n differ pore size implant durat day match bulk gene express data gene measur ident implant notabl discov fundament spatial relationship protein local implant interior exterior either uniqu independ depend implant microstructur dendrit cell marker cdc fibronectin signific domin scaffold interior cell cell adhes marker cd anti inflammatori polar marker cd local exterior last collat spatial bulk inform uniqu spatiotempor express pattern identifi marker fibronectin uncover spatial profil otherwis hidden bulk express result togeth discoveri illustr critic import quantifi spatial express pattern implant facilit paradigm shift iter design mechanist understand rapid assess biomateri statement signific spatial local express protein determin implant success fulli understood quantit high plex profil challeng appli geomx digit spatial profil site specif investig protein product porous implant data collect locat quantiti protein target tissu scaffold differ pore size implant durat day collect parallel match bulk gene express data gene ident implant discov signific spatiotempor express pattern remain otherwis hidden differenti bulk result new approach rapid assess biomateri offer enhanc mechanist understand enabl tailor implant superior regen outcom | D001672;D054457 | T122 |
34,673,227 | reduc thrombogen surfac treat nitinol implant steer alter protein adsorpt blood contact medic implant made nitinol titanium alloy neurovascular flow divert peripher stent disadvantag high thrombogen make use system dual anti plateletanticoagul therapi inevit relat risk devic thrombosi bleed complic meet urgent clinic demand less thrombogen nitinol surfac describ simpl treatment standard commerci avail nitinol render surfac ultra hydrophil function phosphat ion efficaci treatment assess compar standard surfac treat nitinol disk braid equival flow divert static dynam chandler loop blood incub test show drastic reduct thrombus format treat devic surfac chemistri proteom analysi indic key role phosphat calcium ion steer blood protein adsorpt avoid coagul cascad activ platelet adhes good endotheli surfac confirm biocompat treat surfac statement signific titanium alloy nitinol biocompat show favor mechan properti led widespread use medic implant howev contact blood surfac trigger activ intrins coagul cascad may result catastroph thrombot event present result show phosphat function titanium oxid surfac suppress activ coagul cascad platelet avoid subsequ format blood clot novel approach therefor great potenti mitig risk associ either thrombosi bleed complic due system anticoagul patient cardiovascular implant | D000497;D040901 | T091;T197 |
34,673,226 | black drum fish teeth built crush mollusk shell exclus diet hard shell mollusk black drum fish pogonia cromi exhibit one highest bite forc among extant anim present systemat microstructur chemic crystallograph mechan analysi black drum teeth understand structur basi achiev molluscivor requir materi level outermost enameloid show higher modulus e r gpa h gpa report fish teeth attribut stiffen effect zn f dope apatit crystal preferenti co align crystallograph c axe enameloid rod along bite direct high fractur tough k c mpam outer enameloid also promot local yield instead fractur crush contact mollusk shell individu tooth scale molar like teeth high densiti dentin tubul enlarg pulp chamber special dentin bone connect contribut function requir includ confin contact compress stress stiff enameloid enhanc energi absorpt compliant dentin control failur tooth bone composit excess load result show multi scale structur black drum teeth adapt feed hard shell mollusk statement signific black drum fish feed hard shell mollusk requir strong tough wear resist teeth studi present comprehens multiscal materi mechan analysi black drum teeth achiev remark biolog function microscal fluorid zinc dope apatit crystallit outer enameloid region align perpendicular chew surfac repres one stiffest biominer materi found natur inner enameloid region apatit crystal arrang intertwist rod crystallograph misorient increas crack resist tough macroscal molariform geometri two layer design base outer enameloid inner dentin enlarg pulp chamber under strong boni toothplat work synergist contribut teeth crush resist | D014070 | T023 |
34,673,223 | small molecul drug atop dermat rheumatoid arthriti hereditari angioedema review recent trend develop target small molecul drug smds treatment immunolog driven disord includ atop dermat rheumatoid arthriti hereditari angioedema | D054179;D001172;D003876 | T047 |
34,673,222 | current trend medic educ affect allergi immunolog physician learner review current relev trend medic educ undergradu medic educ graduat medic educ continu medic educ allergi clinic immunolog ai communiti | D004501;D004504;D006967;D010820 | T097;T065;T046 |
34,673,221 | factor influenc reintroduct peanut tree nut negat oral food challeng children complianc reintroduct food negat oral food challeng ofc variabl ongo avoid toler food associ recurr allergi reduc qualiti life | D021184;D021183 | T047 |
34,673,220 | asthma social determin health synthes grow bodi literatur role social determin health sdoh asthma asthma dispar | D001249;D064890 | T033;T047;T067 |
34,673,219 | pocket cost gastrointestin cancer patient lack perfect frame problem contribut financi toxic fight cancer econom expens challeng health care payer patient famili median cost cancer care rapid increas last decad although direct indirect cost medic assist frequent sourc distress content howev analysi non medic expens incur direct cancer patient receiv adequ attent develop deeper understand call pocket cost may necessari pocket cost medic care rang medic cost payer howev rang pocket cost show consider variabl differ studi review review avail data concern direct indirect medic cost includ psychosoci one | D005770;D005102 | T191;T081 |
34,673,218 | efficaci first line treatment option transplant inelig multipl myeloma network meta analysi despit major therapeut advanc ration choic appropri first line regimen newli diagnos transplant inelig multipl myeloma tie mm current undefin | D009101 | T191 |
34,673,217 | airborn fine particul matter japan induc lipid synthesi inhibit autophagi hepg cell inhal particul matter diamet less report exacerb fatti liver diseas howev compon mechan particul matter involv hepat lipid metabol autophagi fulli elucid found atmospher particul matter japan stimul lipogenesi hepatocyt even lipid compon remov furthermor demonstr particul matter promot autophagosom format inhibit autophag degrad hepatocyt previous toxic experi particul matter collect atmospher often contain contamin origin filter studi expos powderi particul matter less contamin collect use cyclon impactor system hepg cell human hepatocyt particul matter induc lipogenesi endoplasm reticulum stress hepg cell well previous report particul matter usa china hand autophag flux examin detail particul matter promot autophagosom format inhibit autophag degrad sinc effect similar palmit fatti acid prepar particul matter lipid compon remov aceton compar effect hepg cell untreat one particul matter without lipid compon induc lipid droplet well untreat one although induc less endoplasm reticulum stress result suggest hepat lipid synthesi stimul uptak lipid also compon particul matter | D050155;D052638 | T040;T131;T167 |
34,673,216 | oxyr inactiv reduc growth rate oxid stress defens capnocytophaga ochracea human oral caviti harbor sever bacteria among capnocytophaga ochracea facult anaerob respons earli phase dental plaqu format phase tooth surfac tissu expos various oxid stress colon dental plaqu phase respons hydrogen peroxid h sens transcript regul oxyr may necessari howev date studi elucid role oxyr protein c ochracea | D020868;D018384 | T049;T045 |
34,673,215 | etiolog granulomat lobular mastiti base metagenom next generat sequenc aim comprehens explor etiolog granulomat lobular mastiti glm optim treatment program | D003354;D020031;D058890 | T047 |
34,673,213 | time cours transcriptom profil reveal specif express pattern mad box gene associ distinct development process winter spring wheat shoot apex region new cell produc elong development state wheat shoot apex low temperatur affect cold resist studi morpholog shoot apex overwint character wheat line differ winter spring characterist research show shoot apex autumn sown spring wheat line reach temperatur sensit doubl ridg stage overwint wherea shoot apex winter wheat line found temperatur insensit veget elong stage order explor gene express associ shoot apex differenti winter spring wheat use strand specif rna sequenc profil gene express pattern four time point germin day germin winter wheat cultivar dongnongdongmai dm spring wheat cultivar china spring cs identifi differenti express gene two cultivar regul gene cs involv energi metabol transport seedl stage wherea regul gene dm involv protein dna synthesi mad box gene affect plant growth develop studi mad box differenti express cs dm screen evolutionari tree analysi conduct sampl period cs high express mad box gene induc flower promot gene vrn vrt ag lowli express mad box gene induc flower inhibit homolog gene svp tavrn composit dm cs vrn vrn b vrn db analysi sequenc tavrn traescsag dm cs reveal snp differ promot region snp delet intron region express level cold resist gene dm signific higher cs seedl stage neither dm cs experienc cold studi includ cbf cold induc protein acid desaturas prolin rich protein addit express level auxin relat gene signific higher cs dm day germin studi identifi candid gene associ process differenti shoot apex winter spring wheat seedl stage also rais intern stress toler model winter wheat endogen anticip come stress condit winter | D018506 | T045 |
34,673,212 | meta analysi associ tnfa g snp vitiligo suscept vitiligo autoimmun progress skin depig diseas tumor necrosi factor alpha tnf pro inflammatori cytokin play crucial role vitiligo develop sinc conflict result consensus lack associ tnfa gene g polymorph vitiligo suscept perform meta analysi avail studi investig associ tnfa g polymorph vitiligo risk studi involv vitiligo patient control includ meta analysi meta analysi reveal increas vitiligo risk aa ga aa ga genotyp allel overal p p p p egyptian popul p p p p moreov found associ ga aa ga genotyp asian popul p p allel asian middl eastern popul p p interest diseas activ base analysi reveal signific associ ga aa ga genotyp allel activ vitiligo patient north american popul p moreov found signific associ ga aa ga genotyp allel local vitiligo overal p p p asian p p p popul overal meta analysi suggest involv suscept allel vitiligo suscept overal popul specif asian middl eastern egyptian popul ii vitiligo diseas activ north american popul iii local vitiligo overal popul specif asian popul | D020641 | T086 |
34,673,210 | electrospun silk nanofib promot vitro expans potenti cd cell deriv umbil cord blood stem cell umbil cord blood ucb abl prolifer differenti various somat cell type therebi consid one attract stem cell sourc tissu engin regen medicin howev limit number hematopoiet cd stem cell ucb restrict clinic applic stem cell studi aim expand cd stem cell deriv ucb silk scaffold ucb stem cell extract use magnet cell sort mac character flow cytometri isol cell seed fabric electrospun silk scaffold cultur day real time pcr cell count coloni form assay mtt assay perform evalu expans home stem cell result show higher express cxcr gene number cultur stem cell coloni form unit silk scaffold group day compar tissu cultur plate moreov higher viabil prolifer stem cell seen cell cultur silk scaffold seem electrospun silk scaffold could use suitabl substrat ucb cd stem cell expans | D057139 | T073 |
34,673,209 | genet variant splice factor gene suscept bladder cancer genom wide associ studi demonstr genet variant close relat tumorigenesi progress cancer howev correl genet variant splice factor gene bladder cancer suscept remain unclear | D020641 | T086 |
34,673,204 | phylogenet analysi human melanogast repertoir solut carrier human fli solut carrier slc superfamili largest group transport human role transport solut across plasma membran slcs current divid famili member perform detail mine slc superfamili recent annot famili atyp slcs human melanogast use hidden markov model psi blast analys identifi protein sequenc melanogast protein previous identifi fli total human slc famili found conserv fli famili high conserv perhap reflect famili function role cellular pathway studi provid first collect slc sequenc melanogast serv slc databas use classif slcs phyla | D010802 | T062;T078 |
34,673,203 | differ culprit lesion premenopaus postmenopaus women acut coronari syndrom optic coher tomographi studi differ culprit lesion characterist remain unclear premenopaus postmenopaus women acut coronari syndrom ac optic coher tomographi oct enabl high resolut vivo identif plaqu investig potenti differ culprit lesion premenopaus postmenopaus women ac mean oct | D017698 | T040 |
34,673,202 | one step revers transcript loop mediat isotherm amplif assay optim direct detect cucumb green mottl mosaic virus cucurbit seed cucumb green mottl mosaic virus cgmmv seed born virus caus signific econom loss farm cultiv cucurbit plant increas global trade cucurbit seed essenti develop rapid reliabl conveni diagnost method direct detect cgmmv seed prevent manag diseas develop one step revers transcript loop mediat isotherm amplif rt lamp assay direct detect cgmmv cucurbit seed improv effici one step rt lamp assay six primer design target conserv region gene encod movement protein cgmmv one step rt lamp assay optim improv specif sensit cgmmv detect individu seed comparison detect sensit reveal one step rt lamp assay fold sensit current revers transcript polymeras chain reaction assay use cgmmv quarantin korea collect one step rt lamp assay develop present studi appropri direct detect cgmmv individu cucurbit seed | D048348;D017898 | T005;T045 |
34,673,201 | detail gross anatomi topographi sympathet cardiac nerv relat ganglia syrian hamster mesocricetus auratus detail morpholog topographi sympathet cardiac nerv scns ganglia surround structur syrian hamster examin document general topographi morpholog variat discuss compar anatomi scns ganglia syrian hamster rodent well compar morpholog macroscop evolutionari chang among rodent rabbit domest anim cat dog sheep goat oxen pig hors primat human | D005728;D013564 | T022;T023 |
34,673,200 | evalu reject infect malign outcom elder liver transplant recipi receiv similar level immunosuppress compar younger group elder liver transplant ltx recipi lower risk acut reject compar younger recipi due immunosenesc may benefit reduc immunosuppress minim infecti malign complic aim evalu outcom ltx recipi year compar younger group ltx recipi age year maintain similar level singl center retrospect evalu adult ltx recipi receiv methylprednisolon induct maintain tacrolimus mycophenol mofetil mmf prednison taper total ltx recipi evalu mean age older group compar year younger group p mean tacrolimus level durat mmf steroid compar group similar incid first reject within year elder group vs younger group p statist differ term infect malign patient surviv conclus data suggest elder ltx recipi treat similar level similar year incid reject infect malign patient surviv younger ltx recipi | D016031;D009369 | T191;T061 |
34,673,199 | novel bioaugment strategi boost biochar allevi ammonia toxic continu biomethan studi investig first time ammonia toler methanogen consortia store gel biogel use later time demand bioaugment inocula effici reliev ammonia inhibit continu biomethan system moreov wood biochar assess potenti enhanc novel biogel bioaugment process three thermophil c continu stir tank reactor r bgel r char r mix oper g nh n l expos biogel biochar mixtur biogel biochar respect fourth reactor r ctrl use control result show methan product yield r mix r char r bgel increas respect compar r ctrl highest methan yield achiev synergist interact biogel biochar addit biogel stimul rapid recoveri methanoculleus thermophilus sp syntroph acet oxidis bacteria popul | D000641;D019149 | T074;T121;T197 |
34,673,198 | recent advanc biodegrad biosorpt organ compound wastewat microalga bacteria consortium review litter persist organ pollut pop water stream soil bodi via industri effluent led sever advers effect environ health ecosystem past decad scientist pay effort innov develop pop remov wastewat treatment howev convent method use remov pop wastewat cost could lead secondari pollut includ soil water bodi pollut recent util green mechan biosorpt bioaccumul biodegrad drawn attent prelud potenti green technolog global microalga bacteria consortia emerg one latent wastewat treatment system synergist interact microalga bacteria could profici enhanc exist biolog wastewat treatment system paper critic review comparison convent recent advanc wastewat treatment system mechan microalga bacteria symbiosi system | D058086;D062065 | T204;T069;T083 |
34,673,197 | integr biorefineri process convers lignocellulos biomass valu ad materi pave path toward circular economi lignocellulos biomass effect sustain altern petroleum deriv fuel chemic produc biofuel bio base product despit high avail degrad biomass substanti challeng henc necessari integr sever unit process biochem thermochem physic catalyt convers produc wide rang bio base product integr process enhanc yield reduc reaction time cost effect process integr could signific lead various outcom guid toward circular economi review address integr sever biorefineri process product multifacet product addit modern sustain biorefineri technolog discuss pave path toward circular economi close loop approach | D056804;D008031 | T109;T123 |
34,673,196 | biolog remedi technolog dye heavi metal wastewat treatment new insight pollut environ caus dye heavi metal emit industri becom worldwid problem develop effici environment accept cost effect method wastewat treatment contain dye heavi metal critic biolog base techniqu treat effluent fascin sinc provid sever benefit standard treatment method review assess recent develop use biolog base techniqu remov dye heavi metal wastewat remedi dye heavi metal divers microorgan alga bacteria fungi enzym depict detail ongo biolog method advanc scientif prospect problem futur prognosi highlight review use gain better integr view biolog base wastewat treatment speed futur research function biolog method water purif applic | D019216;D014874;D018508 | T131;T052;T057;T196 |
34,673,195 | challeng microalg biofuel product perspect techno econom feasibl biorefineri stratagem rapid exhaust fossil fuel combin ever increas demand energi led ongo search altern energi sourc meet transport manufactur domest energi demand grown popul microalga forefront altern energi research due signific potenti renew feedstock biofuel howev microalga platform found way industri scale bioenergi product due various technic econom constraint present review provid detail overview challeng microalga product process bioenergi purpos support techno econom assess relat microalga cultiv harvest downstream process requir crude oil biofuel product addit biorefineri approach valor product co product microalga product enhanc techno econom product process discuss | D058086 | T204 |
34,673,194 | product n caproat use food wast thermophil ferment without addit extern electron donor effect produc n caproat food wast without extern electron donor ed investig batch semi continu ferment maximum concentr n caproat reach mg codl semi continu ferment specif n caproat highest solubl cod convers rate n caproat reach end batch ferment product n caproat coupl generat lactat ed facilit chain elong reaction lactat use substrat n butyr mark domin product instead n caproat microbi communiti analysi reveal caproiciproducen rummeliibacillus clostridiumsensustricto key genera relat n caproat product addit n caproat n butyr domin product batch semi continu ferment maximum specif clostridiumsensustricto commit produc n butyr lactat | D002208;D012037 | T057;T109 |
34,673,193 | valor agro industri wast biorefineri process circular bioeconomi critic review energi recoveri wast resourc promis approach toward environment consequ prospect environment sustain util agro industri wast residu feedstock biorefineri process gain widespread attent agro industri various biomass expos differ unit process offer valu various agro industri wast materi agro industri wast generat substanti amount valuabl product fuel chemic energi electr product paper review methodolog valor agro industri wast exploit generat renew energi product addit manag agro industri wast product agro industri wast elabor wast biorefineri process use agro industri wast offer energi also offer environment sustain mode address effect manag wast stream review aim highlight cascad use biomass agro industri wast system approach econom develop | D007220;D007221 | T131;T057;T078 |
34,673,192 | simul optim organosolv base lignocellulos biomass refineri review organosolv pretreat consid core lignocellulos biomass fraction within biorefineri concept organosolv facilit separ major fraction cellulos hemicellulos lignin use renew feedstock produc bioenergi biofuel ad valu biomass deriv chemic effici separ fraction affect econom feasibl biorefineri complex review focus simul organosolv pretreat optim feedstock delignif ii sugar product main hemicellulos iii enzymat digest cellulos fraction iv qualiti lignin simul use technoeconom optim biorefineri complex simul optim implement holist approach consid effici technolog econom environment perform biorefineri oper unit consequ optim organosolv stage first step sustain econom viabl biorefineri complex concept industri ecolog zero wast circular economi | D002482;D008031 | T122;T109;T123 |
34,673,191 | characterist bio oil biochar cotton stalk pyrolysi effect torrefact temperatur durat ammonia environ studi nitrogen contain chemic nitrogen rich biochar prepar use ammonia nh torrefact pretreat technolog effect temperatur durat torrefact characterist torrefact pyrolysi product evalu result indic torrefact temperatur increas c nitrogen content increas signific xps analysi show raw biomass main contain amid n pyrrol n torrefact temperatur durat increas quaternari n format promot amid n pyrrol n pyridin n consum potenti nitrogen dope transform pathway ammonia torrefact process propos gc ms analysi show ammonia torrefact promot format pyridin reduc content oxygen contain speci addit torrefact durat posit effect yield nitrogen contain chemic | D000641;D000077319 | T070;T121;T197 |
34,673,190 | integr approach enabl high bioresourc util bioethanol product whole stillag bioethanol major biofuel industri main produc corn starch dri mill process howev one remain challeng econom effici exploit wast co product improv ethanol product generat valuabl chemic integr approach develop effici util wast cake ethanol product accompani protein extract feed addit high qualiti protein feed produc ethanol alkali extract method extract rate notabl appli two step chemoenzymat strategi supernat solid recycl yield fold improv ethanol glucos xylos product respect compar non pretreat moreov mass balanc analysi found approach signific contribut kgton dri corn increas total ethanol product gain knowledg process design hold potenti transfer sustain biowast manag bioethanol industri | D056804;D000431 | T121;T109 |
34,673,189 | enhanc biodegrad chlortetracyclin via microalga bacteria consortium microbi remov chlortetracyclin ctc low ctc concentr order mgl report studi novel microalga bacteria consortium develop effect ctc biodegrad higher concentr mgl microalga bacteria consortium resist mgl ctc pure microalg cultur could toler mgl ctc ctc remov initi h primarili via biosorpt microalga bacteria consortium adsorpt capac increas mgg biomass h ctc biodegrad microalga bacteria consortium catalyz extracellular enzym secret antibiot stress symbiot bacteri divers analyz high throughput sequenc aerob bacteria porphyrobact devosia domin genera consortium presenc ctc microbi communiti shift occur chloroptast spingopyxi brevundimona domin genera | D002751;D058086 | T204;T195;T109 |
34,673,188 | bioaugment degrad rice straw combin two novel microbi consortia lactic acid bacteria enhanc methan product two consortia lignocellulolyt microb cl yl isol rumen rumin abil facilit degrad rice straw enhanc methan ch product evalu individu combin lactic acid bacteria lab day degrad rice straw powder rsps observ chang physic structur also display signific reduct lignocellulos content combin applic microbi consortia lab effici improv enzymat hydrolysi rsps increas organ acid well mono disaccharid content synergist action microbi consortia lab enhanc ch yield rice straw treat yl lab highest ch product ml ch g vs fivefold control newli identifi microbi consortia capabl effici degrad lignocellulos biomass function synergist lab provid feasibl way biodegrad rice straw enhanc methan product agricultur wast | D056546;D012275 | T007;T002;T168 |
34,673,187 | nuclear magnet reson analysi ascorb acid assist lignocellulos decomposit dilut acid pretreat stimul enzymat hydrolysi effect ascorb acid addit lignin decomposit dilut acid pretreat correspond cellulos convers pretreat biomass studi enhanc ascorb acid addit dose depend decompos residu bulk lignin pretreat poplar analyz hsqc p nmr spectra promot effect lignocellulos decomposit assist ascorb acid addit support nmr analysi analysi show addit ascorb acid signific stimul decompos lignin compar residu bulk lignin stimulatori effect ascorb acid lignocellulos decomposit benefit cellulos convers correspond pretreat materi poplar pretreat assist ascorb acid ww increas final hydrolysi yield promot effect ascorb acid enzym digest obvious higher enzym load | D001205;D008031 | T127;T121;T109;T123 |
34,673,182 | depend caspas signal pathway target deoxynivalenol growth inhibit vitro common found food feed present health risk especi increas growth inhibit human particular infant young children howev relat research studi devot mechan mediat growth retard interest result show caus signific product ros result persist signific releas ino increas activ mitochondri ultrastructur chang decreas moreov signific decreas gh product secret induc dose depend accompani increas caspas il il l ghrh scaveng agent haemoglobin free radic scaveng agent n acetylcystein partial revers mitochondri damag z vad fmk increas level gh decreas level caspas haemoglobin decreas level caspas indic primari target mediat inhibit present research studi first demonstr key mediat induc growth inhibit play critic role interfer gh transcript synthesi current research conduc futur research molecular mechan induc growth inhibit human especi children | D005506 | T068;T067 |
34,673,181 | toxic uptak nuclear transloc ingest micro nanoplast vitro model small intestin epithelium despit mount evid increas micro nanoplast mnps natur environ food drink water littl known potenti health hazard mnps ingest assess toxic uptak environment relev mnps vitro small intestin epithelium sie test mnps includ nm polystyren ps microspher ps psk nm carboxyl modifi ps sphere psc psc pskc secondari mnps inciner polyethylen pei mnps subject phase digest mimic transform gastrointestin tract git digesta appli sie carboxyl mnps signific reduc viabil increas permeabl kd dextran uptak carboxyl ps materi size depend signific greater uptak psc fluoresc confoc imag show psc agglomer enter cell independ endosom suggest diffus other within actin shell suggest phagocytosi mani free within epitheli cell includ agglomer within nuclei pre treatment dynamin inhibitor dyngo partial reduc ps transloc suggest potenti role endocytosi find suggest ingest exposur mnps could serious health consequ underscor urgent need addit detail studi potenti hazard ingest mnps | D002467 | T026 |
34,673,177 | socioeconom status inflamm women earli stage breast cancer mediat bodi mass index breast cancer common cancer among women us women low socioeconom status ses show mark poorer outcom high ses ses may influenc health inflamm although link ses inflammatori biomark investig women breast cancer studi test hypothesi breast cancer patient lower ses would show higher level inflamm higher ses bmi examin mediat associ | D001943 | T191 |
34,673,176 | diffus weight mr spectroscopi dw mrs sensit lps induc chang human glial morphometri preliminari studi low dose lipopolysaccharid lps well establish experiment method induc system inflamm shown microscopi activ microglia rodent current techniqu vivo imag glia human limit tspo transloc protein pet expens methodolog challeng poor cellular specif diffus weight magnet reson spectroscopi dw mrs sensit mr spectra diffus intracellular metabolit potenti provid cell specif inform cellular morpholog preliminari studi appli dw mrs measur chang appar diffus coeffici adc glial neuron metabolit healthi particip underw lps administr protocol hypothes adc glial metabolit select modul lps induc glial activ | D038524;D008070 | T060;T109 |
34,673,174 | antibiot induc gut dysbiosi lead activ microglia impair cholinerg gamma oscil hippocampus antibiot wide appli treatment bacteri infect long term use may lead gut flora dysbiosi detriment effect brain physiolog behavior well cognit perform still strike lack knowledg exist concern electrophysiolog correl antibiot induc chang gut microbiota behavior investig chang synapt transmiss plastic togeth behavior relev network activ hippocampus antibiot treat mice prolong antibiot treatment led reduct myeloid cell pool bone marrow circul surveil brain circul lyc hi inflammatori monocyt adopt proinflammatori phenotyp increas express cd mhc ii central nervous system microglia display subtl activ phenotyp elev cd mhc ii express increas il tnf product well increas number iba cell hippocamp ca ca subregion concomit detect substanti reduct synapt transmiss hippocamp ca antibiot treatment line carbachol induc cholinerg gamma oscil reduc upon antibiot treatment incid hippocamp sharp wave elev alter associ global chang express neurotrophin nerv growth factor induc nitric oxid synthas shown influenc cholinerg system hippocampus overal studi demonstr antibiot induc dysbiosi gut microbiom subsequ alter immun cell function associ reduc synapt transmiss gamma oscil hippocampus brain region critic involv mediat innat cognit behavior | D064806;D017628 | T025;T047;T046 |
34,673,173 | ribo dt autom pipelin infer codon dwell time ribosom profil data protein synthesi energi consum process characteris pivot high regul step gene express net protein output dictat combin translat initi elong termin rate remain difficult measur recent develop ribosom profil enabl infer translat paramet model method inform ribosom posit along mrna present autom reproduc portabl comput pipelin infer relat singl codon codon pair dwell time well gene flux raw ribosom profil sequenc data case studi appli workflow public avail yeast ribosom profil dataset consist independ gene knockout relat rna trna modif uncov effect modif translat elong codon select decod particular knock mod trm increas codon specif dwell time indic potenti trna target highlight effect nucleotid modif ribosom decod rate | D012270;D029701 | T026;T116 |
34,673,171 | quantiti versus qualiti age relat differ muscl volum intramuscular fat mechan properti tricep sura age come reduct qualiti size skelet muscl chang influenc forc generat capac skelet muscl contribut movement deficit accompani age although declin strength remain signific barrier mobil older adult associ age relat chang muscl structur function remain unresolv studi compar age relat differ muscl volum architectur ii quantiti distribut intramuscular fat iii muscl shear modulus index stiff tricep sura younger year older year healthi adult addit explor relationship muscl volum architectur intramuscular fat ankl plantar flexion strength young older adult magnet reson imag use determin muscl volum intramuscular fat content b mode ultrasound use quantifi muscl architectur shear wave elastographi use measur shear modulus ankl strength measur maxim isometr plantar flexion contract found older adult display higher level intramuscular fat yet similar muscl volum medial mg later gastrocnemius lg soleus compar younger adult age relat higher level intramuscular fat associ lower muscl shear modulus lg mg also found muscl physiolog cross section area pcsa account age associ differ intramuscular fat show modest increas associ ankl strength compar pcsa account fat content highlight skelet muscl fat infiltr play role age relat strength deficit fulli explain age relat loss muscl strength suggest factor play signific role | D007537;D018482 | T024;T023;T042 |
34,673,170 | valid simpl sit stand method assess forc veloc profil older adult lower limb muscl strength import determin physic function older adult howev measur clinic set limit requir larg scale cost equip new simpl protocol base sit stand test sts develop measur forc veloc f v power veloc p v profil communiti dwell older adult | D005080;D057187 | T056;T060 |
34,673,168 | thermosensit liposom encapsul hypericin character photodynam effici potent photodynam properti hypericin hyp elicit rang light dose depend anti tumor activ howev low water solubl hamper broad applic therefor administr hyp biolog system requir drug carrier would enabl suffici bioavail stimuli trigger nanocarri sensit endogen exogen stimuli becom attract replac convent therapeut regimen herein produc optim hyp thermosensit liposom hyp tsl self assembl dppc dspc dspe peg hyp tsl display hydrodynam diamet nm adequ encapsul effici good colloid stabil hyp tsl exhibit thermal sensit narrow rang phase transit temperatur c liposom destruct evid afm imag elev temperatur phase transit temperatur uptak tsl hyp mda mb cell signific increas hypertherm treatment c compar uptak averag physiolog temperatur c consequ enhanc cellular reactiv oxygen speci observ hypertherm treatment c half maxim inhibitori concentr hyp tsl reduc fold hypertherm treatment c comparison treatment c hyp tsl consid safe intraven applic compar hemocompat studi coagul time hemolyt potenti conclus enhanc tumor drug avail correl improv therapeut outcom | D006979;D010569 | T130;T131;T061;T109 |
34,673,167 | develop formul cellular mechan lipophil copper chelat treatment wilson diseas copper homeostasi fine regul human avoid detriment impact free intracellular copper ion upon copper accumul biliari excret trigger liver thank traffick atpb copper transport bile canaliculi howev wilson diseas protein mutat lead copper accumul current therapi use cu chelat act extracellular requir life long treatment side effect herein new cu pro chelat encapsul long term stabl nanostructur lipid carrier cellular assay reveal pro chelat protect hepatocyt cu induc cell death besid cellular stress induc moder copper concentr includ protein unfold counteract pro chelat data show pro chelat effici deliv intracellular activ chelat cope copper stress surpass current develop chelat although biolog activ mitig pro chelat nanolipid formul led promis result innov approach outmost import quest better treatment wilson diseas | D006527 | T047 |
34,673,166 | smartphon enabl print medicin print manufactur techniqu transform numer industri sector particular key tool develop fabric medicine personalis individu need patient printer relat larg requir train oper must locat pharmaceut set manufactur dosag form order realis fulli potenti point care manufactur medicin portabl printer easi oper requir report develop printer oper use mobil smartphon printer oper stereolithograph principl use light smartphon screen photopolymeris liquid resin creat solid structur shape print dosag form determin use custom app smartphon warfarin load printlet print tablet various size patient centr shape caplet triangl diamond squar pentagon torus gyroid lattic success print high resolut excel dimension precis use differ photosensit resin drug present amorph form printlet display sustain releas characteris promis proof concept result support futur potenti compact user friend interconnect smartphon base system point care manufactur personalis medic | D010604;D000068997 | T091;T057;T073 |
34,673,165 | underestim contribut solvent phase behavior high drug load amorph solid dispers spite fact spray dri wide appli formul amorph solid dispers asd influenc solvent physic properti asd still complet understood therefor impact organ solvent kinet stabil drug compon polym matrix prepar either film cast spray dri investig one polym pvpva togeth one four poor water solubl drug naproxen indomethacin fenofibr diazepam film cast spray dri use either methanol ethanol isopropanol acetonitril aceton dichloromethan ethyl acet everi combin highest drug load could formul singl amorph phase establish solvent determin maximum amount drug could kinet trap polym matrix therebi extent kinet stabil maximum drug load compar thermodynam solubl drug seven solvent general relat thermodynam solubl drug highest drug load attain use solvent henc contribut solvent generat supersatur state underestim | D002626;D004364 | T091;T121 |
34,673,164 | deep eutect system overview fundament aspect current understand drug deliveri applic deep eutect system des relat new concept field drug deliveri scienc des class eutect mixtur compris two compon eutect point far melt temperatur pure compon strong hydrogen bond interact des constitu respons signific lower melt point des signific number molecul reach drug discoveri phase drug develop phase poor biopharmaceut attribut solubl permeabl des novel altern overcom issu last year dess wide use differ pharmaceut chemic process howev comprehens inform regard drug deliveri potenti avail review deal fundament aspect type prepar thermodynam toxic biodegrad applic field drug deliveri current challeng futur prospect translat aspect des drug deliveri system also discuss | D004364 | T121 |
34,673,163 | enter coat bacteriophag tablet oral administr gastrointestin infect intestin pseudomona aeruginosa high problemat immunocompromis patient intens care unit hospit phage therapi attract altern supplementari therapi antibiot kill multidrug resist bacteria also minimis disrupt gut microflora solid oral dosag form ie tablet potenti effect deliv viabl phage gastrointestin tract formul studi scarc studi pseudomona target phage pev use model produc tablet suitabl oral deliveri utilis industri scale tablet compress tablet coat machin phage tablet produc spray dri phage ii direct compress phage powder tablet iii tablet coat result phage tablet neglig phage titr reduct throughout process pass british pharmacopeia test includ friabil weight variat disintegr dissolut tablet well weight gain disintegr hcl ph phosphat buffer coat tablet develop formul method utilis produc tablet contain phage phage cocktail effect enter bacteri infect | D001435;D000071059 | T061;T005 |
34,673,162 | nanophytosom enhanc rutin efficaci oral administr diabet treatment streptozotocin induc diabet rat rutin natur antioxid compound sever therapeut benefit howev applic bioactiv compound limit due low stabil bioavail overcom limit studi aim encapsul rutin nanophytosom nps evalu therapeut potenc nanocarri streptozotocin stz induc diabet rat particl size zeta potenti encapsul effici prepar nps nm mv respect vivo studi show oral administr rutin load nps contain mg rutinkg per day week effect free rutin control hyperglycemia hyperlipidemia stz induc diabet rat addit administr rutin load nps regul activ liver marker enzym level total hemoglobin glycat hemoglobin diabet rat antioxid defens diabet rat increas administr rutin load nps free rutin moreov histopatholog studi show administr rutin load nps restor diabet induc damag kidney liver pancrea conclus encapsul rutin phytosom effect techniqu benefit therapeut potenti especi attenu diabet complic | D003921;D012431 | T050;T121;T109 |
34,673,161 | challeng share decis make treatment advanc ckd qualit studi patient clinician greater understand challeng share decis make treatment advanc chronic kidney diseas ckd need support implement share decis make clinic practic | D000080536;D051436 | T047;T041 |
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