PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,673,160 | dialysi nonadher kidney transplant outcom retrospect cohort studi concern nonadher behavior often prevent dialysi patient enter waitlist transplant even though inconsist associ behavior posttranspl outcom examin associ plausibl metric nonadher relat dialysi treatment posttranspl outcom | D054559;D007676;D016030 | T047;T061 |
34,673,158 | short term ambient particul air pollut exposur microrna blood pressur lung function ambient particul air pollut risk factor cardiovascular respiratori diseas yet biolog mechan under associ well understood current studi aim investig mediat role microrna associ person pm exposur blood pressur lung function one hundr twenti adult truck driver offic worker age year assess june follow week later microrna extract peripher blood sampl compar truck driver signific increas fef fev fev fvc decreas pm offic worker p accord bonferroni correct threshold p valu use person pm data show signific posit associ mir adjust age bmi smoke status habitu alcohol use mediat effect mir associ person pm exposur fef b ci pef b ci fev fvc b ci signific truck driver adjust covari similar associ blood pressur result demonstr microrna potenti mediat associ pm lung function subsequ studi need elucid potenti mechan action mediat effect microrna achiev process | D000393;D000397;D035683 | T123;T131;T114;T080;T069 |
34,673,157 | radon potenti map jangsu gun south korea use probabilist deep learn algorithm advers health effect associ inhal ingest natur occur radon gas produc uranium decay chain mean need identifi high risk area studi detect radon prone area use geograph inform system gis base probabilist machin learn method includ frequenc ratio fr model convolut neural network cnn ten influenc factor name elev slope topograph wet index twi valley depth fault densiti litholog averag soil copper cu calcium oxid cao ferric oxid fe lead pb concentr analyz total rock sampl high activ concentr index valu divid random train valid dataset ratio train model area categor high high moder low low radon area accord model approxim studi area classifi high high risk final radon potenti map valid use area receiv oper characterist curv auc analysi show cnn algorithm superior fr method former auc valu obtain use train valid dataset respect howev algorithm high predict power slope litholog twi best predictor radon affect area result provid new inform regard spatial distribut radon could inform develop new residenti area radon screen import reduc public exposur high level natur occur radiat | D000396;D000077321;D011834;D011886;D014501 | T131;T196;T066;T059 |
34,673,156 | fluorid exposur caus colon microbiota dysbiosi destroy microenviron disturb antimicrobi peptid express colon colon microenviron microbiota dysbiosi close relat various human metabol diseas studi total healthi femal mice expos fluorid f mgl f drink water day effect f intestin barrier divers composit colon microbiota evalu meanwhil relationship among f induc colon microbiota alter antimicrobi peptid amp express short chain fatti acid scfas level also assess result suggest f decreas goblet cell number glycoprotein express colon high throughput rrna gene sequenc result demonstr f exposur induc divers communiti composit colon microbiota signific chang linear discrimin analysi effect size lefs analysi identifi predomin characterist taxa may biomark respons f exposur f induc intestin microbiota perturb lead signific decreas scfas level colon immunofluoresc result show f increas protein express interleukin il il p disturb express interleukin receptor il ra il r p p addit increas express il il cooper enhanc mrna express amp respons f induc microbiota perturb collect destroy microenviron disturb amp primari reason microbiota dysbiosi colon f exposur colon homoeostasi imbal would help find sourc f induc chronic system diseas | D064806;D000069196 | T007;T047;T001;T046 |
34,673,155 | spatial distribut potenti sourc microplast songhua river flow urban center northeast china microplast mps elicit increas concern freshwat system worldwid howev littl inform avail mp pollut songhua river third largest river china understand sourc pathway mps limit studi mps sampl river water wastewat treatment plant five citi along songhua river investig occurr spatial distribut characterist potenti sourc mps polyethylen polypropylen polystyren account total mps mp pollut determin spatial heterogen concentr mps urban center alway consider higher upper reach irregular variat observ urban center lower reach citi urban one primari drive forc spatial variabl statist signific posit correl p valu note averag concentr mps river water popul densiti p number industri enterpris design size p citi line fiber major shape white domin color larg mm small mm mp particl account multipl correspond analysi new methodolog approach conduct elucid sourc mps first time potenti sourc mps includ daili use fish agricultur industri product work provid inform mp contamin futur studi freshwat system new insight sourc apportion mps | D000080545;D014874 | T131;T122 |
34,673,153 | associ haemodynam cardiopulmonari resuscit patient outcom defin target blood flow chest compress cc previous report various haemodynam pattern domin arteri venous pressur observ cc studi aim evalu arteri venous perfus pressur cc determin associ patient outcom | D016887;D058687 | T046;T061 |
34,673,152 | risk factor outcom recurr paediatr hospit cardiac arrest retrospect multicent cohort studi recurr hospit cardiac arrest ihca associ morbid mortal adult aim describ risk factor outcom paediatr recurr ihca | D016887;D006323 | T047;T061;T046 |
34,673,148 | cultur relat differ neural process probabl mix lotteri valu base decis make studi evalu differ econom risk take western east asian reflect cultur differ analyt holist process probabilist outcom valu base decis twenti seven american us taiwanes tw young adult complet function magnet reson imag fmri lotteri choic task lct experi particip accept reject stake vari probabl win lose differ magnitud point tw particip accept stake win probabl wherea us particip reduc accept rate win stake discrimin win probabl decreas group reject lose stake win probabl similar frequenc critic ventromedi prefront cortex vmpfc respons correspond show greater discrimin win probabl condit us tw group find highlight neurocognit mechan vmpfc cultur differ distinguish probabilist reward outcom shape neural comput risk prospect | D001931;D017397 | T023;T060;T062;T029;T030 |
34,673,147 | human serum albumin fusion protein therapeut target amyloid beta alzheim diseas alzheim diseas ad character amyloid beta plaqu neurofibrillari tangl ad drug develop limit due presenc blood brain barrier bbb prevent effici uptak therapeut brain solv problem use tran activ transcript tat transduc domain ad human serum albumin hsa carrier increas half life drug within bodi addit includ protein interest lower deposit andor neurofibrillari tangl made hsa fusion protein design al contain cystatin c cysc core mechan action moieti construct contain tandem repeat tat dtat purif kda al investig therapeut potenti al vitro ad mous model tg evalu permeabl al bbb use cell basedhuman bbb model show dtat play role facilit deliveri kda protein found al attenu induc neurotox pc cell tg mice brain plaqu dramat reduc al treat mice data suggest bbb cross albumin fusion protein al cysc activ moieti diseas modifi treatment ad | D000544 | T048;T047 |
34,673,145 | low plasma ergothionein level associ neurodegener cerebrovascular diseas dementia ergothionein et dietari amino thion strong antioxid cytoprotect properti possibl therapeut potenti neurodegen vascular diseas decreas blood concentr et found patient mild cognit impair status neurodegen vascular dementia current unclear address cross section studi conduct particip consist cognit impair nci cognit impair dementia cind well dementia alzheim diseas ad vascular dementia subject underw blood draw neuropsycholog assess well neuroimag assess cerebrovascular diseas cevd brain atrophi plasma et well metabolit l hercynin measur use high sensit liquid chromatographi tandem mass spectrometri lc msms plasma et concentr lowest dementia p vs nci cind intermedi level cind p vs nci signific increas l hercynin et ratio also observ dementia p vs nci multivari model adjust demograph vascular risk factor lower level et signific associ dementia without cevd et associ cind signific presenc cevd furthermor lower et level also associ white matter hyperintens brain atrophi marker reduc global cortic thick hippocamp volum increment decreas et level along cind dementia clinic continuum suggest low level et associ diseas sever could potenti biomark cognit impair defici et may contribut toward neurodegener cevd associ cognit impair possibl via exacerb oxid stress condit | D000544;D002561;D060825;D004880 | T048;T047;T109;T123 |
34,673,144 | critic role uniqu azido substitut chloro semiquinon radic intermedi synergist toxic sodium azid chlorocatechol carcinogen shown previous expos bacteria tetrachlorocatechol tcc sodium azid nan togeth caus synergist cytotox biphas mode howev under chemic mechan remain unclear studi unexpect ring contract h furanon two quinoid compound identifi major minor reaction product respect two unusu azido substitut chloro semiquinon radic detect character major radic intermedi complementari applic direct esr hplcesi q tof high resolut ms studi nitrogen isotop label nan taken togeth propos novel molecular mechan reaction tccnan n may attack tetrachloro semiquinon radic form two transient azido trichloro diazido dichloro semiquinon radic consecut second radic intermedi may either undergo unusu zwitt azido cleavag form less toxic ring contract h furanon product oxid form toxic quinoid product amino azido dichloro benzoquinon good correl observ biphas format toxic quinon due two compet decomposit pathway radic intermedi biphas synerg tcc nan depend molar ratio first report detect identif two uniqu azido substitut chloro semiquinon radic unpreced ring contract mechan via unusu mild facil zwitt azido rearrang | D002273;D011809 | T131;T109 |
34,673,143 | thioredoxin reductas level associ nrf pathway activ tumor recurr non small cell lung cancer activ mutat keapnrf pathway character subset non small cell lung cancer nsclc associ chemoresist poor prognosi herein evalu relationship oxid stress relat gene overal surviv data lung cancer dataset thioredoxin reductas txnrd stood signific predictor poor outcom cohort nsclc patient high txnrd protein level correl shorter diseas free surviv distal metastasi free surviv post surgeri includ subset individu treat platinum base adjuv chemotherapi bioinformat analysi reveal nsclc tumor harbor genet alter nrf pathway keap nfel cul mutat nfel amplif overexpress txnrd associ egfr kras tp pikca mutat found addit nuclear accumul nrf overlap upregul txnrd protein nsclc tumor function cell assay gene depend analysi reveal nrf txnrd pivot role keap mutant cell surviv keap mutant overexpress txnrd less suscept cytotox effect txnrd inhibitor auranofin compar wild type cell line inhibit nrf sirna ml glutathion deplet buthionin sulfoximin sensit keap mutant cell auranofin nrf knockdown gsh deplet also augment cisplatin cytotox cell wherea auranofin effect summari find suggest txnrd key determin malign phenotyp keap mutant cell although protein surrog marker nrf pathway activ predict tumor recurr possibl aggress phenotyp associ nrf hyperactiv nsclc | D002289;D008175;D054481 | T191;T116;T126 |
34,673,142 | neuron sensit synapt facilit superfici dorsal horn rat reserpin induc pain model chronic widespread pain one import issu solv medic practic impair spinal descend pain inhibitori system due decreas monoamin neurotransmitt assum caus nocicept hypersensit chronic pain condit like describ patient fibromyalgia fm howev respons behavior synapt transmiss spinal dorsal horn neuron respons reserpin remain clarifi examin activ superfici dorsal horn sdh neuron well excitatori inhibitori postsynapt input sdh neuron use putat rat model fm establish inject reserpin extracellular record vivo reveal sdh neuron sensit mechan stimul appli neuron recept field mechan sensit neuron spontan activ sensit effect evid day day reserpin treatment subsid day treatment later use patch clamp record vivo spontan excitatori postsynapt current sepsc sdh neuron found increas pain model spontan inhibitori postsynapt current sipsc sdh neuron decreas result demonstr sdh neuron strong sensit respons reserpin treatment increas excitatori decreas inhibitori postsynapt input could respons spinal nocicept hypersensit putat fm model | D059350;D012110 | T047;T121;T184;T109 |
34,673,141 | cell adhes suppress autophagi via srcfak mediat phosphoryl inhibit ampk autophagi multi step process regul part amp activ protein kinas ampk phosphoryl threonin ampk subunit enhanc ampk kinas activ result activ downstream signal integrin mediat cell adhes activ src focal adhes kinas fak signal complex regul multipl cellular process includ cell surviv show src signal lead direct phosphoryl ampk subunit novel site tyrosin result suppress ampk phosphoryl autophagi upon integrin mediat cell adhes use chemic inhibitor genet cell model target mutagenesi confirm import role src fak suppress ampk signal autophagi induc various addit stimuli includ glucos starvat furthermor found autophagi suppress hydroxychloroquin promot apoptosi cancer cell model treat src inhibitor find reveal link src fak complex ampk autophagi regul may play import role mainten normal cellular homeostasi tumor progress | D055372;D019061 | T116;T126 |
34,673,140 | tlr nile tilapia conserv receptor interact myd tirap activ nf b vitro toll like receptor tlrs play critic role innat immun respons fish studi isol cdna sequenc nile tilapia tlr ontlr deduc ontlr protein contain signal peptid leucin rich repeat lrrs c termin lrr lrr ct transmembran region high conserv tir domain healthi nile tilapia ontlr transcript broad express examin tissu highest express level spleen infect streptococcus agalactia ontlr transcript upregul gill kidney stimul polyinosin polycytidyl acid poli c express level ontlr signific downregul intestin wherea ontlr transcript signific upregul kidney challeng lipopolysaccharid lps express level ontlr signific upregul spleen kidney subcellular local show ontlr express cytoplasm tlr signific increas myd depend nf b activ howev result pull assay show ontlr interact myd tirap bind assay reveal specif ontlr pathogen associ molecular pattern pamp bacteria includ agalactia aeromona hydrophila poli c lps taken togeth find suggest ontlr pattern recognit receptor prr might play import role immun respons pathogen invas | D023681;D005393 | T013;T047 |
34,673,136 | electroacupunctur prevent lps induc neuroinflamm via upregul pick tlr complex microglia hippocampus sepsi associ encephalopathi sae common complic sepsi caus neuroinflamm electroacupunctur ea use treat sae under mechan clear lack pick aggrav inflammatori respons mice sepsi therefor sought investig whether pick involv protect effect electroacupunctur sae studi mice treat ea lipopolysaccharid lps treatment behavior test microgli activ hippocampus neuron surviv inflammatori factor pick tlr well tlr relat protein erk jnk p assess ea treatment pick tlr tlr relat protein well pick tlr complex level assess bv cell treat lps pick sirna pick polypeptid result indic ea could improv neurolog assess reduc activ microgli tlr express proinflammatori cytokin ea also reduc express tlr phosphoryl erkjnkp increas express pick tlr complex pick knockdown promot express tlr phosphoryl erkjnkp bv cell effect revers pick polypeptid result suggest ea may reduc neuroinflamm respons decreas inflammatori factor final protect sae increas format pick tlr complex microglia | D015671;D008070 | T061;T109 |
34,673,128 | metronom chemotherapi regimen target therapi non hodgkin lymphoma best two world novel drug rapid move forward treatment paradigm non hodgkin lymphoma nhls notwithstand especi aggress subtyp chemotherapi remain pillar treatment inde combin high effect maximum toler dose chemotherapi mtd chemo novel drug far fallen short expect often caus excess toxic metronom chemotherapi mchemo frequent long term administr low dose cytotox drug may allow effect toler combin mchemo pharmacodynam describ pleiotrop fact may differ cellular molecular target drug schedul modifi although mchemo littl explor nhls pre clinic studi lymphoma model address activ mchemo combin novel drug shown promis result includ inhibitor histon deacetylas mtor pikmtor well immun checkpoint inhibitor anti pd l moreov impress report recent shown oral mchemo schedul without rituximab effect shrink b cell aggress nhls inde regimen allow elder frail patient achiev sustain remiss toxic prove manag opinion oral mchemo activ easi start well toler inexpens therapeut approach deserv investig import mchemo hold promis empow activ novel target therapi without caus excess toxic | D059250;D004305 | T079;T081 |
34,673,125 | erector spina plane block analgesia cesarean deliveri systemat review meta analysi erector spina plane block espb region block may use sever surgeri howev evid regard obstetr procedur pool literatur | D000698;D009407;D014147 | T121;T061;T109 |
34,673,123 | hrv pattern associ differ affect regul system sex differ adolesc evolutionari perspect human behavior propos exist three emot regul system ie threat drive sooth system unbalanc function system repres greater risk emot dysregul psychopatholog recent year heart rate variabl hrv report accur index emot regul although adolesc character multipl neurophysiolog psycholog social chang studi explor hrv pattern emot regul system development stage studi standard procedur sp aim elicit three differ system develop valid expert n communiti adolesc n studi differ hrv pattern across three emot regul system across sex investig sampl communiti adolesc n male age year old result show threat drive system associ decreas hrv sooth system associ decreas heart rate sex differ found activ threat system male maintain decreas trend hrv index rest recoveri femal show decreas hrv activ system overal physiolog correl specif emot regul system corrobor theoret assumpt moreov sp abl trigger system independ measur physiolog data avail use futur research | D000080103;D012727 | T032;T041 |
34,673,122 | antibodi drug conjug gastrointestin cancer lab clinic develop antibodi drug conjug adc one fastest grow biotherapeut oncolog still infanc gastrointestin gi cancer clinic applic improv patient surviv adc base approach develop tumor specif antigen antibodi carri cytotox agent precis target deliv chemotherapeut tumor site date adc approv us fda clinic develop phase differ oncolog indic howev adc base therapi gi cancer still far high effici clinic outcom limit success adc lesson learn past use develop newer generat adc gi cancer review comprehens assess key compon adc includ tumor marker antibodi cytotox payload linkag strategi focus technic improv futur trend pipelin clinic translat various preclin clinic adc use gastrointestin malign target composit bioconjug along preclin clinic outcom discuss emphasi also given new generat adc employ novel mab payload linker bioconjug method also includ | D000970;D005770;D018796 | T191;T121;T109;T129 |
34,673,121 | green revolut grain revolut florigen frontier burgeon human popul dent global brim buffer stock well gain food grain product howev immin global starvat avert precis scientif intervent pragmat polici chang eulog green revolut miracl rice wheat obtain morphometr chang ideotyp two crop yield bumper harvest nucleat asia translat latin america alter agronom trait two crop result tinker phyto hormon gibberellin recent anoth plant hormon cytokinin gain promin involv grain revolut rice field crop suo moto homeostasi ck cytokinin oxidas enzym govern cardin shoot apic meristem produc new flower primordia therebi enhanc grain number similar flower hormon florigen impact sympodia format flower fruit product tomato role heterozygos induc heterosi florigen revolution tomato product cellular homeostasi ck ck oxidis enzym ckx enhanc rice product path break review highlight role phytohormon grain revolut crop specif fine tune gibberellin cytokinin florigen accomplish maximum yield potenti field crop | D060405 | T123 |
34,673,120 | enhanc astaxanthin product haematococcus pluviali use zinc oxid nanoparticl today great interest use astaxanthin due potenti health advantag applic differ type nanoparticl nps stress agent enhanc astaxanthin product haematococcus pluviali microalga strain report literatur studi effect differ concentr zinc oxid zno nps enhanc astaxanthin product h pluviali investig first zno nps synthes zinc nitrat precursor sodium hydroxid chemic method peel extract pomegran green method reduc agent studi cell viabil stimul astaxanthin product h pluviali cell expos differ concentr ie gml zno nps synthes powder character scan electron microscopi sem x ray diffract xrd dynam light scatter dls method character result show pure zno nps success synthes via method uniform particl size distribut averag particl size green synthes zno nps nm smaller chemic synthes one nm maximum astaxanthin product mgg dri biomass h pluviali achiev gml green synthes zno nps exposur h pluviali comparison control cultur day howev zno nps concentr gml toxic microalga result conclud specif amount zno nps could consid worthi candid enhanc astaxanthin product h pluviali | D000077105;D053758;D015034 | T121;T002;T073;T197 |
34,673,119 | next generat sequenc human respiratori syncyti virus subgroup b genom human respiratori syncyti virus hrsv lead caus acut respiratori ill young children worldwid whole genom sequenc hrsv offer enhanc resolut strain variabl epidemiolog surveil provid genom inform essenti antivir vaccin develop amplicon one step rt pcr assay amplicon nest rt pcr assay enhanc sensit develop amplifi whole hrsv genom sampl contain high low viral load respect nineti six hrsv posit sampl compris clinic specimen virus isol c valu amplifi success use amplicon one step rt pcr method multiplex singl miseq run genom coverag exceed sampl amplicon nest rt pcr ngs method use generat hrsv full length genom clinic specimen c valu rang phylogenet analysi genom sequenc obtain clinic specimen reveal wide divers hrsv genotyp demonstr methodolog robust | D018357;D018113 | T047;T005 |
34,673,117 | new mous model type diabet mellitus establish combin high fat diet streptozotocin glucocorticoid stabl induc type diabet model tdm still need explor basic clinic research due nonuniform model method unstabl consequ aim explor establish optim induc tdm model mice exhibit insulin resist cell damag | D004195 | T050 |
34,673,115 | macrophag migrat inhibitori factor mif multifacet cytokin regul genet physiolog strategi macrophag migrat inhibitori factor mif proinflammatori cytokin encod within function polymorph genet locus mif initi recogn cytokin generat activ cell recent day identifi multipot key cytokin secret mani cell type involv immun respons physiolog process mif high conserv kda secretori protein involv numer biolog process express secret profil mif suggest mif ubiquit constitut express almost mammalian cell vital numer physiolog process mif critic upstream mediat host innat adapt immun surviv pathway result clearanc pathogen thus play protect role infecti diseas hand mif immun modul acceler detriment inflamm promot cancer metastasi progress thus worsen diseas condit sever report demonstr genet physiolog factor includ mif gene polymorph posttransl regul receptor bind control function activ mif take consider multi facet role mif physiolog patholog thought time review summar expression function regul mif function mechan associ benefici patholog role mif target therapi thus review provid overview mif regul respons potenc therapi target mif | D008263 | T129;T116;T123 |
34,673,114 | disinfect method sar cov systemat review sever acut respiratori syndrom coronavirus sar cov causat agent coronavirus diseas caus million death worldwid virus transmit inhal infecti particl suspend air direct deposit mucous membran indirect contact via contamin surfac disinfect method halt transmiss import pandem futur viral infect | D000086382;D000086402 | T047;T005;T067 |
34,673,113 | engin translat compon genet code expans expans genet code consist four base amino acid divers build block excit topic synthet biolog mani biochem compon involv gene express therefor ad new compon genet code requir engin mani compon interact genet code expans advanc signific last two decad engin sever compon involv protein synthesi compon includ trnaaminoacyl trna synthetas new codon ribosom elong factor tu addit biosynthesi enhanc uptak non canon amino acid attempt made meaning progress review discuss effort engin translat compon improv genet code expans technolog | D000596;D000604;D005815;D005818 | T116;T121;T123;T063;T085;T126 |
34,673,112 | speech languag impair behavior variant frontotempor dementia systemat review although behavior variant frontotempor dementia bvftd classic defin behavior socio emot chang impair often extend cognit function includ earli speech languag deficit relat diseas core neural disrupt yet scope clinic relev remain poor understood systemat review character disturb bvftd consid clinic neuroanatom genet neuropatholog defin subgroup includ experiment studi least bvftd patient diagnos use accept criteria compar speech languag outcom bvftd patient healthi control bvftd subgroup result reveal extens heterogen deficit across cohort consist lexico semant read write prosod impair b inconsist deficit motor speech grammar c relat preserv phonolog skill also preliminari find suggest sever speech languag deficit might associ global cognit impair predomin tempor fronto tempor atrophi mapt mutat vs corf although recogn impair contribut patient character phenotyp potenti inform diagnosi manag | D057180;D007805 | T033;T048;T047 |
34,673,111 | environment certainti influenc neural system regul respons threat stress flexibl calibr threat respond accord environ adapt process allow anim avoid harm also maintain engag goal direct action calibr process refer threat respons regul requir anim calcul probabl given encount result threat respond accord review neural correl two high studi form threat respons suppress extinct safeti condit focus relat level certainti uncertainti surround environ alter acquisit applic process also discuss evid indic alter threat respons regul follow stress exposur includ enhanc fear condit disrupt extinct safeti condit conclud discuss research use anim model cope examin impact stressor control threat respond highlight potenti previous experi control form cope protect effect futur advers | D003214;D005239 | T041 |
34,673,110 | influenc oxytocin base intervent sleep wake sleep relat behaviour neurobiolog systemat review preclin clinic studi oxytocin oxt system garner consider interest due influenc divers behaviour howev scant research consid influenc oxytocin sleep wake sleep relat behaviour neurobiolog consequ object systemat review assess extant preclin clinic evid influenc oxytocin base intervent sleep wake outcom primari search conduct use six electron databas studi preclin clinic includ base inclus criteria studi evalu risk bias use syrcl tool cochran risk bias tool preclin clinic studi respect result indic manipul oxt system influenc sleep wake outcom preclin evid suggest wake promot influenc oxt system activ wherea clinic evid suggest littl sleep promot influenc oxt oxt dose identifi like modulatori factor oxt induc effect sleep wake behaviour futur studi necessari valid strengthen tentat conclus influenc oxt sleep wake behaviour | D009446;D010121 | T091;T116;T121;T125 |
34,673,106 | review role human serum albumin predict diagnos treatment covid sever acut respiratori syndrom corona virus sar cov keep destroy normal social integr worldwid bring extraordinari medic servic cultur financi interrupt individu diabet demonstr higher risk complic even death expos sar cov regardless pandem scale infect present limit comprehens potenti impact sar cov individu diabet human serum albumin hsa abund circul plasma protein human serum attract interest research suscept non enzymat glycat reaction albumin regul express ace target receptor covid hypoalbuminemia coagulopathi vascular diseas connect covid appear predict outcom independ age morbid review discuss recent evid aceac ratio could influenc human serum albumin suscept individu sar cov infect outcom covid diseas | D000086382 | T047;T067 |
34,673,105 | gold instal hyaluron acid hydrogel ultrasound trigger thermal elev demand cargo releas tempor quantit control cargo releas challeng issu applic hydrogel cancer therapi report hyaluron acid hydrogel base depot provid ultrasound trigger thermal elev demand cargo releas hyaluron acid hydrogel develop employ gold cluster sonotherm crosslink grown cargo prevent undesir leakag ultrasound induc dissoci result demonstr presenc ultrasound w hyaluron acid hydrogel signific increas temperatur c lead dissoci gold cluster subsequ cargo releas addit prepar hydrogel exhibit appropri mechan properti superior biostabl inject hydrogel vivo applic | D065546 | T070 |
34,673,099 | ultra light poli lactic acid sio aerogel composit foam fulli biodegrad full life cycl sustain insul materi studi fulli biodegrad ultra light poli lactic acid silicon dioxid plasio aerogel nanocomposit ultra low thermal conduct success fabric pla use produc lactic acid lactic acid produc carbohydr rheolog properti pla enhanc diphenylmethan diisocyan mdi foam properti cell densiti cell size uniform mechan properti thermal conduct thermal diffus pla improv sio aerogel final ultra low densiti foam materi prepar supercrit co densiti pla foam low gcm thermal conduct low wmk pla base composit use mani field thermal insul vibrat damp packag fulli biodegrad sustain throughout life cycl meet global trend energi save emiss reduct | D003252 | T073 |
34,673,098 | impact coronavirus diseas pandem adher ocular hypotens medic patient primari open angl glaucoma emerg evid suggest coronavirus diseas covid pandem disrupt health behavior medic adher object studi determin whether adher ocular hypotens medic affect pandem identifi factor associ chang | D000086402 | T005 |
34,673,097 | develop fulli redispers dri nanocryst use sucros laurat stabil increas surfac area dissolut rate poor water solubl drug much interest convert poor water solubl drug nanocryst provid extrem high surfac area increas dissolut rate oral bioavail howev nanocryst prepar aqueous suspens suspens dri develop solid dosag form nanocryst agglomer larg particl reduc excess surfac energi success develop drug product essenti agglomer revers dri nanocryst regain origin particl size redispers aqueous media establish sucros laurat serv superb stabil ensur complet redispers dri nanocryst aqueous media mild agit nanocryst nm three neutral drug fenofibr danazol probucol produc sucros laurat media mill suspens dri tray dri vacuum spray dri lyophil dri solid tablet redispers origin particl size spontan preliminari studi show sucros laurat also redispers acid basic drug indic versatil applic fatti acid ester anoth disaccharid lactos laurat also perform like sucros laurat thus develop method retain high dissolut rate implic high bioavail nanocryst solid formul | D053758;D014867 | T121;T073;T197 |
34,673,096 | vitro simul environ upper gastrointestin lumen drug administr fed state use tim system comparison lumin data adult evalu environ tim lumin compart use paracetamol danazol solut suspens fed state configur data compar recent publish data healthi adult tim experi perform fold downscal volum secret gastric duoden compart adequ reflect lumin data adult h post drug dose ph valu duoden jejun compart adequ reflect averag ph valu adult gastric compart ph valu initi higher averag valu adult reach baselin level earlier adult environ tim gastric compart jejun compart adequ reflect averag total paracetamol danazol amount per volum content adult stomach upper small intestin respect total bile acid concentr micellar phase content duoden jejun compart overestim micellar concentr upper small intestin adult adjust gastric emptyingacid secret rate bile acid ident duoden jejun compart applic dynam bile acid secret rate expect improv relev lumin condit tim compart adult | D007421;D013270 | T023 |
34,673,095 | ich qd drug product element risk assess use element impur excipi databas purpos public show element impur excipi databas use assist execut drug product element impur risk assess requir ich qd guidelin result exercis demonstr databas use conjug sourc inform credibl sourc element impur level excipi therefor valuabl sourc inform complet drug product risk assess use collect data help reduc burden analyt test element impur excipi | D004340;D005079 | T120;T122;T068 |
34,673,094 | physiolog base pharmacokinet model hiv drug combin role lymphat system subcutan dose part model drug combin nanoparticl previous develop mechan base pharmacokinet mbpk model character pk lymphocyt target long act hiv drug combin nanoparticl dcnp formul lopinavir ritonavir tenofovir mbpk describ time cours plasma drug concentr provid initi hypothesi lymphat pk dcnp anatom physiolog interpret mbpk limit part report develop physiolog base pharmacokinet pbpk model detail evalu system lymphat pk drug associ dcnp dcnp model link pbpk model present earlier part account disposit releas free drug key featur dcnp model uptak inject dose subcutan site adjac lymphoid depot rout node within throughout lymphat network subsequ passag blood circul furthermor model account dcnp transport lymph lymphat recircul mononuclear cell migrat present pbpk model extend nano drug combin target transit lymphat system pbpk model may allow scale predict dcnp pk human | D015658;D053758 | T047;T073 |
34,673,093 | physiolog base pharmacokinet model hiv drug combin role lymphat system subcutan dose part model free drug mixtur drug combin nanoparticl dcnp allow formul multipl hiv drug one inject nonhuman primat nhp drug dcnp demonstr long act pharmacokinet pk blood lymph node render suitabl target long act antiretrovir therapi tlc art support translat tlc art clinic object present physiolog base pk pbpk model tool control mechan affect rather complex dcnp drug pk two speci contribut simultan drug pk drug dissoci dcnp part drug retain dcnp part present separ describ pbpk model nanoparticl free drug free drug model built subcutan inject suspend lopinavir ritonavir tenofovir nhp valid extern experi novelti design lymphat network part whole bodi pbpk system includ major lymphat region cervic axillari hilar mesenter inguin node detailedregion descript lymphat system mononuclear cell repres unpreced level predict render free drug model extend small drug molecul target lymphat system region cellular level | D015658;D019438 | T047;T121;T109 |
34,673,092 | develop cell target sirna deliveri system hiv use modifi superparamagnet iron oxid nanoparticl vitro studi spite promis properti small interf rnas sirna treatment infecti diseas safe effici sirna deliveri target cell still challeng research effect sirna deliveri approach hiv report use target modifi superparamagnet iron oxid nanoparticl spion trimethyl chitosan coat spion tmc spion contain sirna synthes chemic conjug cd specif monoclon antibodi target moieti prepar nanoparticl exhibit high sirna load effici diamet nm zeta potenti mv result cell viabil assay reveal low cytotox optim nanoparticl cellular deliveri target nanoparticl cell gene silenc effici nanoparticl contain anti nef sirna dramat improv compar nontarget nanoparticl conclus studi offer promis target deliveri platform induc gene silenc target cell approach may find potenti use design effect vehicl mani therapeut applic particular hiv treatment | D048271;D015497;D058185;D053758 | T121;T073;T109;T130;T005 |
34,673,091 | optim delin clinic target volum thymoma post resect set multi center studi definit clinic target volum ctv post oper radiotherapi port thymoma larg unexplor aim studi analyz differ ctv delin radiat oncologist rto surgeon | D013945;D013953 | T191 |
34,673,087 | anemosid activ tlr depend phenotyp macrophag polar repress breast tumor growth angiogenesi polar macrophag previous demonstr close relat immun inflammatori process tumorigenesi progress breast cancer present studi anemosid activ compound pulsatilla saponin screen polar macrophag classic activ macrophag phenotyp found activ tlrnf bmapk signal pathway increas express cd marker macrophag macrophag increas typic macrophag pro inflammatori cytokin tnf il express tlr depend manner macrophag cancer cell co cultur system establish evalu whether could switch tumor associ macrophag tam phenotyp co cultur system increas express il macrophag wherebi suppress mcf breast cancer cell line prolifer vegf mediat angiogenesi moreov induc macrophag polar murin breast cancer model effect inhibit tumor growth tumor angiogenesi collect find indic induc macrophag polar repress breast tumorigenesi via target tlrnf bmapk signal pathway studi provid rational util tradit chines medicin extract immunotherapi breast cancer | D009389 | T046 |
34,673,085 | tempor trend intensif glucos lower therapi type diabet itali data amd annal initi impact clinic inertia clinic inertia negat affect type diabet tdm manag evalu chang prescript pattern hypoglycem drug year observ period larg popul tdm outpati effect metabol control | D003924;D008687 | T047;T121;T109 |
34,673,084 | cell therapi research diabet pancreat cell differenti pluripot stem cell human pluripot stem cell pscs embryon induc pluripot stem cell ipsc differenti pancreat isletsin vitrofor decad idea get enough cell cell transplant diabet find standard cell therapi diabet essenti logarithm increas global popul peopl diabet insuffici avail human cadaver pancrea moreov better insight development biolog thein vitro cell differenti protocol depend thein vivo cell organogenesi various protocol pancreat cell differenti develop protocol base modul cell signal pathway growth factor small molecul rnai approach direct differenti use transcript factor genom edit growth factor free differenti protocol epigenet modul differenti approach encapsul strategi also report better glycem control endocrin modul review various aforementionedin vitro cell differenti protocol human pscs respect comparison challeng past present futur literatur review primarili pubm year till date use mention keyword | D003920;D039904 | T025;T047 |
34,673,083 | identif lncrnacircrna mirna mrna network explor effect ricin toxin induc inflamm raw cell ricin toxin rt ribosom inactiv protein deriv bean castor oil plant previous studi report rt induc product inflammatori cytokin caus inflammatori injuri raw cell order explor various biolog process long noncod rna lncrna circular rna circrna micro rna mirna endogen non code rnas cerna may particip pro inflammatori mechan rt ngml treat normal raw cell first sequenc rna seq compar differenti express gene obtain hub gene enrich inflammatori relat signal pathway base result conclud lncrnacircrna mirna mrna network final verifi key gene pathway qrt pcr wb elisa experi result open mapk signal pathway tnf signal pathway via tnfr found involv rt induc inflamm work provid refer search cerna target therapeut drug rt induc inflammatori injuri futur | D035683;D062085;D012276 | T131;T116;T114;T123 |
34,673,082 | rodent diet aid fallaci calor restrict understand molecular mechan normal age prerequisit signific improv human health span calor restrict cr delay age serv yardstick evalu intervent extend life span howev mice given unlimit access food suffer sever obes health gain cr depend control mice suffici overweight less obes mous strain benefit far less cr pharmacolog intervent increas life span includ resveratrol rapamycin nicotinamid mononucleotid metformin also reduc bodi weight primat cr delay age unless control group eat enough suffer obes relat diseas human surviv optim bodi mass index achiev without cr intervent mere diet aid nt slow age healthi weight individu cr human optim weight safe declar useless sinc overwhelm evid hunger underweight starvat reduc fit surviv qualiti life obes control cr howev truli delay age mechan laid follow tumor suppress theori age | D031204;D009765 | T033;T047;T061 |
34,673,081 | crisi respons among essenti worker children covid pandem limit research conduct mental health concern frontlin essenti worker children covid pandem unit state us studi examin associ work frontlin us covid pandem march juli person crisi text concern eg self harm suicid thought anxietystress substanc abus frontlin essenti worker children frontlin worker use novel data set crisi text servic crisi text line ctl wide use throughout us general estim equat examin individu associ eight specif crisi type depress stressanxieti self harm suicid thought substanc abus isol relationship issu abus frontlin work child frontlin worker earli phase pandem use ctl concern proxi preval mental health issu found children worker specif youngest demograph year femal non conform youth higher risk specif crisi event covid pandem addit hispan children worker report higher rate stressanxieti wherea african american children worker higher rate abus depress frontlin worker higher risk suicid thought risk crisi event general highest non binari transgend male user increas ctl usag among frontlin worker note across day spike local covid case research date focus mental health frontlin essenti worker studi highlight troubl trend psycholog stress among children worker support intervent mental health resourc need frontlin essenti worker children | D000086382;D058873 | T047;T067 |
34,673,080 | lifecours socioeconom posit diabet incid reason geograph racial differ stroke regard studi low socioeconom posit sep across lifecours associ type diabet tdm examin whether econom dispar differ race sex includ african american aa white particip age year nation unit state reason geograph racial differ stroke regard cohort without tdm baselin incid tdm defin fast glucos mgdl random glucos mgdl use tdm medic follow deriv sep score childhood csep adulthood asep use calcul cumul cumsep score social mobil defin chang sep fit race stratifi logist regress model estim associ lifecours sep indic tdm adjust covari addit test sep sex interact median rang year follow tdm incid per person among aa per person among white particip low csep associ tdm incid among aa ci white particip attenu adjust asep contrast low cumsep associ tdm incid racial group tdm risk similar stabl low sep increas downward mobil compar stabl high sep group wherea upward mobil increas tdm risk among aa differ sex observ among aa low csep independ associ tdm csep may shape later life experi health risk | D003924;D020521 | T047 |
34,673,078 | project futur drought impact simul crop yield south asia use ensembl machin learn approach understand develop mechan drought event character futur drought metric impact crop yield crucial ensur food secur global import south asia therefor present studi assess chang futur project drought metric evalu futur risk yield reduct drought intens character magnitud intens durat futur drought mean spei drought index use cmip coupl model inter comparison phase climat model impact futur drought crop yield quantifi isi mp inter sector impact model inter comparison project crop model propos non linear ensembl random forest rf gradient boost machin gbm result suggest high drought magnitud longer drought durat project region south asia high drought intens come shorter durat also found afghanistan pakistan india experi longer drought durat futur propos ensembl machin learn eml approach high predict skill minimum valu rmse mae maximum valu r compar stand alon method rf gbm yield loss risk project drought driven impact crop yield demonstr high risk yield loss extrem drought event encount loss futur rice wheat maiz crop respect furthermor drought yield loss risk dynam suggest one unit decreas spei valu would lead decreas yield rice wheat maiz crop respect studi provid notabl direct polici agenc build resist crop product drought impact region critic climat chang | D000090082;D055864 | T070;T170;T066 |
34,673,077 | polym quantif use rock eval devic identif plastic sediment work artifici thermal degrad experi use rock eval devic perform select polym microspher sampl pe pp pe pa pa pfa pet main idea work first creat databas differ polym standard respons use specif rock eval fidir peak signal sever specif rock eval paramet defin character polym famili instanc polym character specif quantifi paramet like total hc polym total co polym totalco polym tpeak polym among other studi attempt demonstr quick thermal degrad method also use character plastic content detect type quantiti sedimentari sampl result indic investig polym show specif rock eval paramet consid use characterist polym famili main tpeak polym toc polym pc polym rc polym total hc polym total co polym total co polym paramet sampl contain differ miner matric eg sand shale marl carbon also mix polym differ concentr vari wt composit sampl also analyz order evalu thermal degrad compar specif rock eval fidir signatur exampl composit sampl show excel linear correl toc pc rc total hc co co paramet versus amount polym differ concentr although work still need methodolog propos distinguish quantifi presenc plastic environ appli propos polym rock eval databas | D010969;D011108 | T167;T104;T122 |
34,673,076 | machin learn predict nitrat groundwat use drink suppli contermin unit state groundwat import sourc drink water suppli contermin unit state conus presenc high nitrat concentr may limit usabl groundwat area potenti negat health effect predict locat high nitrat groundwat need focus mitig relief effort three dimension extrem gradient boost xgb machin learn model develop predict distribut nitrat nitrat predict km resolut two drink water zone variabl depth one domest suppli one public suppli model use measur nitrat concentr well includ predictor variabl repres well characterist hydrolog condit soil type geolog land use climat nitrogen input predictor variabl deriv empir numer process base model also includ integr inform control process condit model provid accur estim nation region scale train r hold r data fit compar favor previous studi predict nitrat concentr less mgl across conus nation well depth soil climat characterist absenc develop land use among influenti explanatori factor area either water suppli zone predict nitrat concentr greater mgl howev peopl depend groundwat drink suppli area predict high concentr nitrat preval central conus area predict high nitrat concentr appli manur farm fertil agricultur land use influenti predictor variabl work repres first applic xgb three dimension nation scale groundwat qualiti model provid signific mileston effort document nitrat groundwat across conus | D060587;D009566 | T070;T082;T197;T081 |
34,673,075 | microplast fish meal exposur rout aquacultur anim microplast mps wide detect mani marin fish fish meal contamin mp may constitut potenti threat aquacultur anim studi analyz characterist mp fish meal ten major fish meal produc countri around world microplast isol fish meal examin microscop identifi use fourier transform infrar microspectroscopi ft ir result show mp pollut wide detect fish meal sampl ten countri averag mp abund fish meal itemsg higher level china peru myanmar might relat high pollut level fish habitat isol mps fiber main shape type common size total polym identifi cellophan cp polypropylen pp polyethylen teraphal pet common type total amount mp ingest fish meal differ cultur anim also estim atlant salmon salmon salar ingest largest number mps item red swamp crayfish procambarus clarkii ingest smallest number mps item thus fish meal constitut import exposur rout mps aquacultur anim result studi provid basi assess potenti health risk mps fish meal around world | D000080545;D010969 | T167;T122 |
34,673,074 | adsorpt behavior mechan antibiot norfloxacin degrad nondegrad microplast misus antibiot plastic signific increas environment pollut problem associ contamin moreov microplast adsorb pollut environ howev mechan antibiot adsorpt degrad nondegrad microplast complet understood studi investig environment behavior norfloxacin use polybutylen succin pbs degrad microplast compar convent microplast polystyren ps polyethylen pe order adsorpt capac ps pbs pe adsorpt behavior fit well pseudo second order kinet langmuir isotherm model indic monolay adsorpt process thermodynam endotherm non spontan control chemic physic mechan includ conjug hydrogen bond ion exchang electrostat interact adsorpt capac microplast higher solut ph around pka valu ph valu ionic strength dissolv organ matter inhibit adsorpt process ps pbs amount adsorb onto mps initi decreas increas increas coexist heavi metal ion zn pb could promot adsorpt pe studi reveal interact mechan microplast antibiot provid comprehens theoret basi ecolog environment risk assess differ microplast | D000080545;D010969 | T167;T122 |
34,673,073 | first pilot scale demonstr partial nitritationanammox hydroxyapatit process treat effluent anaerob membran bioreactor fed actual municip wastewat recent report synthet low strength wastewat excel nitrogen remov rate nrr accompani phosphorus remov could achiev partial nitritationanammox pna hydroxyapatit hap process thus research investig perform pilot scale pna hap process treat effluent anaerob membran bioreactor anmbr fed actual municip wastewat result show hydraul retent time h influent ammonium concentr rang mgl bod rang mgl averag nrr nitrogen remov effici kgm respect specif activ test sludg confirm pna process main nitrogen metabol pathway effluent nitrat bod almost zero indic exist denitrif activ reactor given oxygen condit heterotroph organ matter oxid activ also occur reactor sludg analysi confirm phosphat format sludg thus reactor four kind biolog activ chemic crystal occur harmoni sludg mix liquid volatil suspend solid gl low distribut rang granul size obvious sludg high dispers base well settl abil sludg oper infer close bond biomass hap sludg help enhanc settleabl sludg granul besid phosphorus contain sludg suitabl fertil studi demonstr pna hap process ideal altern treat effluent anmbr process municip wastewat treatment | D017886;D062065 | T121;T083;T122;T197;T069 |
34,673,072 | identifi ecosystem servic bundl spatiotempor characterist trade off synergi coal mine area high groundwat tabl understand spatiotempor characterist interact among ecosystem servic ess crucial challeng task maintain human well achiev sustain region develop howev understand spatiotempor interact multipl ess differ grid scale within differ ecosystem servic bundl esb relat limit particular coal mine area high groundwat tabl cma hgt land use drastic chang result mine subsid studi examin cma hgt huainan aim identifi esb explor spatiotempor characterist trade offssynergi among ess distinct grid scale esb five ess relat provis regul mainten includ food product fp water yield wy soil conserv sc carbon sequestr cs biodivers mainten bm quantifi use differ biolog model period spatiotempor trade offssynergi among ess explor use correl analysi signific test differ scale spatiotempor distribut main characterist distinct esb identifi use self organ map som calinski criterion interact among ess differ esb detect relationship ess land use coal product cp explor use redund analysi rda result demonstr spatiotempor trade off general observ among provis servic distinct grid scale within differ esb meanwhil spatiotempor synergi general appear regul mainten servic distinct grid scale interact among ess present tempor dynam spatial heterogen scale depend due relationship fp bm sc cs chang increas research scale three esb esb esb esb identifi grid scale spatial locat vari across differ period area variat cover less studi area bm synergist fp wy sc cs wy trade relationship fp esb wy trade relationship fp sc cs bm esb esb bm synergist fp sc cs trade relationship wy cultiv land construct land cp main drive factor wsa esb esb esb certain degre chang relationship ess land usecp relationship among ess differ grid scale esb time space indic strong region heterogen scale depend result provid detail guidelin formul spatial target ecosystem manag restor program es payment polici | D003032;D060587 | T070;T082;T090;T081 |
34,673,071 | balanc carbon speci combin stabl isotop ratio show critic switch toward bicarbon uptak cyanobacteria bloom next water qualiti deterior cyanobacteria bloom affect turnov aqueous carbon includ dissolv inorgan carbon dic dissolv organ carbon doc particul organ carbon poc investig interact three phase stabl isotop freshwat pond period cyanobacteri bloom period month help map turnov sourc aqueous carbon bloom event bloom event poc isotop valu c poc increas aqueous co co aq fell atmospher equilibr valu atm addit carbon isotop enrich co aq poc co phyto rang lowest fraction observ ph valu increas c poc decreas co phyto valu low pco high ph like caus activ carbon concentr mechan ccm mechan correl preval assimil c enrich hco surpris co aq still contribut poc pool pco valu around atm threshold reduc co phyto suggest incorpor c enrich hco | D001639;D000458 | T007;T121;T196;T197 |
34,673,070 | role plant base altern food sustain healthi food system consumpt trend uk global transform toward sustain food system crucial deliv climat chang mitig target worldwid high middl incom set plant base meat dairi altern present potenti substitut anim sourc food pathway transit sustain diet examin plant base altern food pbaf consumpt trend uk analys repeat cross section food consumpt data nation diet nutrit survey dietari data individu age year analys assess aggreg chang intak pbaf six food group play role transform dietari chang characterist associ consumpt pbaf explor use logist regress consumpt pattern high low meat consum explor examin intak potenti anim product substitut food group proport individu report consumpt pbaf increas p compar pbaf consumpt rose p femal like male report consumpt pbaf p millenni age year like generat report pbaf consumpt p compar generat z age year traditionalist age year individu highest incom tertil p among low meat consum pbaf consumpt averag higher high meat consum g versus g pbaf per day p result support hypothesi pivot role pbaf transit toward sustain food system uk demonstr becom increas popular among uk consum highlight urgent need assess detail environment health impact larg scale popul wide consumpt pbaf comparison anim base equival | D006078;D008460;D010944 | T002;T168;T064 |
34,673,069 | effect oxid stress induc environment relev concentr fluoxetin embryon develop danio rerio fluoxetin flx psychoact drug act antidepress flx one world best sell prescript antidepress flx wide use treatment various psychiatr disord reason drug may eventu end aquat environ via municip industri hospit discharg even though occurr flx aquat environ report ubiquit toxic effect drug may induc especi environment relev concentr essenti biolog process aquat organ requir attent light inform work aim investig influenc fluoxetin oxid stress induc got embryon develop danio rerio purpos rerio embryo h post fertil expos environment relev concentr ng l fluoxetin h post fecund along exposur surviv alter embryon develop teratogen effect evalu use stereomicroscop furthermor oxid stress biomark superoxid dismutas catalas glutathion peroxidas lipid peroxid hydroperoxid carbonyl content evalu h post fecund lc ec teratogen index ng l ng l respect main teratogen effect induc fluoxetin pericardi edema hatch retard spine alter craniofaci malform concern oxid stress integr biomark ibr analysi demonstr concentr increas oxid damag biomark got influenc embryo antioxid enzym thus fluoxetin induc import oxid stress respons embryo rerio collect result allow us conclud flx danger drug earli life stage rerio due high teratogen potenti flx oxid stress induc may involv toxic process | D005473;D015027 | T013;T121;T109 |
34,673,068 | climat chang mitig potenti biochar forestri residu boreal condit forest harvest residu low competit biomass feedstock usual left decay site forestri oper remov pyrolyt convers biochar seen opportun reduc terrestri co emiss mitig climat chang mitig effect biochar howev ultim depend avail biomass feedstock thus co remov biochar need assess relat capac suppli biochar system biomass feedstock prolong time scale relev climat mitig present studi use assembl empir model forecast effect harvest residu remov soil c storag technic capac biochar mitig nation scale emiss centuri use norway case studi boreal condit estim mitig potenti vari tg co equival yr could attribut increas soil c stock coproduct bioenergi valu correspond emiss norwegian agricultur sector total nation emiss illustr deploy biochar forest harvest residu countri larg forestri sector relat economi popul size like relat small contribut nation emiss reduct target may larg effect agricultur emiss commit strategi biochar deploy need consid biochar mitig effect limit feedstock suppli need critic assess | D057231;D016468 | T070;T090 |
34,673,067 | applic hyperspectr imag technolog rapid identif microplast farmland soil microplast mps emerg environment pollut accumul soil advers affect soil biota studi aim employ hyperspectr imag technolog rapid screen classif mps farmland soil studi total hyperspectr data collect set farmland soil sampl hyperspectr imag wavelength rang nm begin hyperspectr data preprocess savitzki golay g smooth filter mean normal second princip compon analysi pca use minim dimens hyperspectr data henc amount data make subsequ model easier construct cumul contribut rate first three princip compon reach includ main inform origin spectral data final three model includ decis tree dt support vector machin svm convolut neural network cnn establish achiev well classif effect three mp polym includ polyethylen pe polypropylen pp polyvinyl chlorid pvc farmland soil compar recognit accuraci three model classif accuraci dt svm respect cnn model base g smooth filter obtain best predict effect classif accuraci reach exhibit obvious advantag classif effect altogeth result show propos hyperspectr imag techniqu identifi soil mps rapid nondestruct provid effect autom method detect polym requir rapid simpl sampl prepar | D000080545;D012987 | T167;T122 |
34,673,066 | novel hybrid support vector regress metaheurist algorithm groundwat spring potenti map limit groundwat resourc overexploit becom major challeng sustain develop worldwid studi innov hybrid approach propos generat groundwat spring potenti map gspm sarab plain locat lorestan provinc iran includ new best worst method bwm stepwis weight assess ratio analysi swara support vector machin learn method svr harri hawk optim hho bat algorithm ba first step involv inventori map prepar contain spring locat random spring point select train data remain select valid base review literatur avail data thirteen factor generat independ variabl bwm swara method use identifi correl occurr spring factor final use svr ba svr hho hybrid model potenti map groundwat spring generat evalu receiv oper characterist roc sever statist evalu sensit specif accuraci kappa index valid train data set show success rate swara svr ba swara svr hho bwm svr ba bwm svr hho model respect result reveal small differ bwm svr hho perform better train compar model evalu predict rate show valu area roc curv swara svr ba swara svr hho bwm svr hho bwm svr ba respect accord result although model excel perform accuraci bwm svr ba accur predict hybrid model present studi use accur effect methodolog improv result spatial model probabl groundwat occurr | D060587 | T070;T082;T081 |
34,673,065 | protozoa reduct secondari wastewat treatment two water reclam facil state nevada usa administr code requir log enter virus reductioninactiv log giardia cyst reduct log cryptosporidium oocyst reduct categori reclaim water suitabl indirect potabl reus ipr base raw wastewat potabl reus water accur demonstr log reduct valu lrvs secondari biolog treatment prior advanc water treatment train enabl redund resili ipr project maintain high level public confid lrvs cryptosporidium giardia result secondari biolog treatment fulli establish due wide rang perform variabl result differ type secondari biolog treatment process employ water reclam one year investig two full scale northern nevada eg mgd lday water reclam facil wrfs conduct monitor cryptosporidium oocyst giardia cyst untreat wastewat secondari effluent studi aim establish secondari treatment lrvs monitor wrf perform attempt correl perform protozoan reduct california ipr regul nevada ipr regul model base maximum concentr log cystsl giardia log oocystsl cryptosporidium recoveri correct giardia cryptosporidium concentr measur untreat influent sampl wrf log cystsl th percentil maximum log cystsl log oocystsl maximum log oocystsl respect secondari treatment wrfs produc secondari effluent consist better feder state nevada requir perform within oper envelop secondari facil given result appear minimum conserv estim lrvs well oper secondari activ sludg treatment plant th percentil lrv credit cryptosporidium lrv giardia warrant minimum lrvs consist conserv review avail literatur | D003458;D018508 | T052;T204;T057 |
34,673,064 | plankton divers anthropocen ship vs aquacultur along eastern adriat coast assess dna metabarcod coastal ecosystem global expos pervas anthropogen activ caus suit human infrastructur enterpris ship port aquacultur facil fish tourism anthropogen activ may lead chang ecosystem biodivers follow loss ecosystem function servic ship industri aquacultur also recogn main vector introduct marin non indigen speci nis worldwid studi use dna metabarcod base method investig plankton biodivers vari anthropogen pressur ship bivalv aquacultur along eastern adriat coast northernmost part mediterranean sea compar assess reveal similar communiti structur among investig coastal locat northern central southern adriat whole plankton communiti consid differ signific port aquacultur site howev proport uniqu zotus port sampl remark higher aquacultur site vs indic port area may receiv higher abund speci rich nis aquacultur site import differ two type anthropogen impact habitat high abund three notori invad leidyi giga h elegan late summer aquacultur site northern adriat therefor plankton communiti area pressur aquacultur activ also establish nis port area probabl greater introduct pressur nis aquacultur site may experi greater communiti chang due establish | D000087602;D017753 | T070;T082;T068 |
34,673,063 | simultan evalu kinet releas labil arsenic phosphorus agricultur soil use cerium oxid base dgt adsorptiondesorpt arsenic agricultur soil utmost import evalu kinet releas potenti enter food chain uptak crop howev mobil soil close relat migrat behavior soil phosphorus p due chemic similar distribut desorpt kinet p four differ type farmland soil simultan estim cerium oxid base diffus gradient thin film techniqu ceo dgt coupl dynam model dgt induc flux soil dif ceo dgt deploy soil h investig interact p migrat behavior accumul mass dgt devic show revers order p among four soil indic competit adsorpt soil solid distribut coeffici k dl labil p deriv dif model mutual exclus clay soil reduc pool size labil increas irrevers adsorpt soil particl adsorpt rate constant much smaller p desorpt rate constant compar among four soil soil highest soil labil asp molar ratio measur dgt show largest potenti phytotox p could reach equilibrium resuppli within min dgt deplet signific negat correl observ desorpt rate k b clay content soil | D001151;D012987 | T167;T131;T121;T196 |
34,673,062 | characterist coalb water coal coal seam situat red river basin vietnam depth understand hydrogeochem characterist coal mine help establish effect success explor program coalb methan cbm studi provid comprehens analysi hydrogeolog characterist characterist coalb water characterist coal sampl coal seam locat red river basin rrb physicochem characterist along microbi composit coalb water critic analyz high concentr chlorid sodium found coalb water presum due coal mine stratigraph associ marin marin transit bed correl occurr microb chemic compon coalb water establish characterist coal systemat analyz includ proxim ultim petrograph analys base coal macer coal rank classifi low rank sub bitumin vitrinit reflect r max suggest type low rank coal favor biogen methan generat pore structur pore type character use differ method includ low temperatur nitrogen adsorptiondesorpt ltna mercuri intrus porosimetri mip scan electron microscopi sem coal studi area micropor macropor featur pore type coal also character use sem primari genet pore type red river coal includ plant tissu hole blowhol | D003031;D014867 | T167;T121;T109;T197 |
34,673,061 | sensit simpl low cost method covid wastewat surveil institut level sar cov respiratori virus also detect signific proport fecal sampl covid case recent studi shown wastewat surveil low cost tool compar massiv diagnost test track covid outbreak communiti studi focus sampl wastewat treatment plant institut level wastewat surveil may serv well earli warn purpos specif geograph areaspopul emerg case track immedi action execut event posit wastewat signal studi novel moor swab method develop use wastewat surveil covid institut level swab sampl test swab collect three campus two build posit sar cov rna studi quarantin build known number case indic method sensit enough detect case build addit comparison grab sampl moor swab sampl hospit sewag line indic moor swab sensit grab sampl offer simpl inexpens method obtain composit sampl virus wastewat h period result suggest collect analys moor swab sar cov rna detect sensit low cost easi use tool covid surveil use institut set could deploy low resourc set identifi emerg covid cluster communiti | D000086382 | T047;T067 |
34,673,060 | remedi zinc contamin groundwat iron oxid situ adsorpt barrier lab field heavi metal zinc degrad microorgan form long contamin plume groundwat convent method remedi heavi metal contamin site exampl excav pump treat expens requir long oper time induc interest new technolog situ adsorpt barrier immobil heavi metal contamin studi present step criteria laboratori test field studi necessari success implement situ adsorpt barrier immobil zinc groundwat sediment sampl contamin site brought lab adsorpt zinc goethit nanoparticl studi batch flow system mimick field condit goethit nanoparticl reveal situ adsorpt capac approxim mg zn per g goethit transport experi sediment column indic expect radius influenc least inject goethit nanoparticl find valid pilot scale field studi situ adsorpt barrier ca implement zinc contamin aquif inject nanoparticl irrevers deposit desir locat within h disloc groundwat flow despit constant increas inflow zinc barrier short contact time goethit zinc barrier dissolv zinc effect immobil ca day zinc concentr increas slowli downstream barrier barrier still retain zinc inflow groundwat studi demonstr applic goethit nanoparticl immobil heavi metal situ highlight criteria upscal laboratori base determin field scale | D060587;D015032 | T082;T121;T123;T196;T081;T070 |
34,673,059 | detect sar cov urban stormwat environment reservoir potenti interfac human anim sourc wastewat found harbor sar cov persist sarscov stormwat potenti transmiss poor understood plausibl virus detect stormwat sampl human origin fecal contamin may occur sourc like sanitari sewer overflow leaki wastewat pipe non human anim wast potenti contamin pathway possibl stormwat could serv environment reservoir transmiss pathway sar cov object studi determin whether presenc sar cov could detect stormwat via rt ddpcr revers transcript digit droplet pcr quantifi human specif fecal contamin use microbi sourc track examin whether rainfal characterist influenc virus concentr accomplish object investig whether sar cov could detect storm sewer outfal drain singl domin land use columbus xenia springboro ohio sampl collect minimum one sar cov target gene n us cdc cn cdc e detect sampl singl signific correl p anteced dri period uscdc n gene found target gene concentr rainfal characterist group citi two signific relationship emerg show citi differ level sar cov e gene given differ scale counti level covid confirm case covid rate signific correl stormwat outfal scale sar cov gene concentr countywid covid data accur portray neighborhood scale confirm covid case rate potenti hazard may aris human fecal contamin present stormwat facilit futur investig threat viral outbreak via surfac water fecal contamin may occur futur studi investig whether human abl contract sar cov surfac water factor may affect viral longev transmiss | D000086382;D000086402 | T047;T005;T067 |
34,673,058 | occurr cross interfac transfer phthalat ester mangrov wetland dongzhai harbor china phthalat ester pae wide use plastic extens present various environment media continu transport land sea howev pae well character multipl media mangrov wetland import land sea interfac studi investig distribut transfer six pae water sediment mangrov fish dongzhai harbor mangrov forest dongzhai harbor largest china surround shrimp pond villag pae ubiquit studi area mean concentr rang pae gl water gkg dri weight dw sediment gkg dw mangrov plant detect nd gkg fish among six pae di n butyl phthalat dbp di ethylhexyl phthalat dehp predomin concentr pae mangrov plant tend decreas river coast tidal gulli might relat period inund tide studi pae bioaccumul show concentr pae herbivor fish higher carnivor fish speci larger individu lower concentr pae di n octyl phthalat dnop dehp tend transfer water sediment four less hydrophob pae dbp like releas sediment water result provid import inform distribut fate pae mangrov wetland | D004952;D053833 | T070;T083;T109 |
34,673,057 | factor affect cadmium accumul soil profil urban agricultur area soil cd pollut serious environment issu associ human activ howev factor determin exogen cd dynam soil profil complex environ well understood base region observ soil profil across chengdu plain studi explor key factor control cd accumul soil profil actual field condit result show total soil cd content decreas mg kg increas soil depth effect phosphat fertil rate road densiti precipit differ total soil cd content observ topsoil agricultur land use type topographi impact contrast signific differ total soil cd content among differ parent materi type found cm soil depth one sampl test show signific cd accumul occur whole soil profil soil form q quaternari holocen grey alluvium soil form q quaternari pleistocen old alluvium q grey brown alluvium show signific cd accumul cm soil layer topsoil acid solubl cd account largest proport total cd soil form q grey alluvium reduc cd main fraction soil form q grey brown alluvium reduc cd residu cd contribut largest proport total soil cd soil form q old alluvium result indic parent materi decis factor determin magnitud depth exogen cd accumul soil profil due impact cd fraction distribut find suggest parent materi induc cd fraction distribut accumul consid effect explor target remedi strategi cd pollut | D002104;D012987 | T167;T131;T196 |
34,673,056 | corncob ash boost ferment hydrogen product wast activ sludg increas demand sustain develop recycl util wast receiv widespread attent studi propos green method use one wast corncob ash boost microbi product hydrogen anoth wast wast activ sludg anaerob ferment corncob ash dosag ferment hydrogen product posit correl maximum product hydrogen reach mlg vs time control group without corncob ash dosag mlg vs mechanist studi found corncob ash benefici solubil hydrolysi acetogenesi process involv ferment hydrogen product process microbi communiti analysi indic corncob ash enrich hydrolyt microorgan eg bacteroid sp leptolinea sp less impact acidifi microorgan compar control group strategi use corncob ash boost product hydrogen anaerob wast activ sludg ferment propos studi might provid new wast control wast paradigm make sludg dispos wastewat treatment sustain | D012722;D003313 | T069;T168;T002 |
34,673,055 | occurr risk assess antibiot surfac water chaohu lake tributari china extens use antibiot treat human anim plant result contamin aquat environ pose potenti threat public health aquat life henc topic great concern worldwid lake consid antibiot rich reservoir mani antibiot discharg river enter lake chaohu lake one top five freshwat lake china studi aim provid current evalu antibiot present surfac water chaohu lake basin end occurr antibiot categor differ group investig studi area impact inflow river distribut assess result show concentr antibiot water sampl rang ngl antibiot detect sampl site among nanfeih shiwulih river close citi contribut antibiot pollut indic widespread occurr antibiot studi area risk assess base risk quotient method indic ofloxacin ciprofloxacin sulfamethoxazol erythromycin norfloxacin lake water pose high ecolog risk alga sulfamethazin pose high risk plant rq | D000900;D060106 | T070;T195;T121;T083 |
34,673,053 | singl molecul studi reveal regulatori interact master kinas pdk akt pkc leukocyt migrat control lead edg chemosensori pathway generat regulatori lipid phosphatidylinositol trisphosph pip growth signal therebi drive lead edg expans attract gradient toward site infect inflamm tissu damag pip also serv import growth signal grow cell oncogenesi kinas pdk akt pkb pkc key compon plasma membran base pip ca signal circuit regul process pdk akt recruit membran pip wherea pkc recruit membran ca three master kinas phosphoregul array protein target exampl pdk activ akt pkc agc kinas phosphoryl key site pdk believ form pdk akt pdk pkc heterodim stabil pdk interact fragment pif interact pdk pif pocket pif motif agc bind partner present first knowledg singl molecul studi full length pdk akt target membran surfac well interact full length pkc studi direct detect membran bound pdk akt pdk pkc heterodim stabil pif interact form physiolog ligand concentr pkc exhibit eightfold higher pdk affin akt competit displac akt pdk akt heterodim ensembl activ measur match condit reveal pdk activ akt via cis mechan phosphoryl akt molecul pdk akt heterodim wherea pkc act competit inhibitor phosphoactiv reaction displac akt pdk overal find provid insight bind regulatori interact three master kinas target membran suggest recent describ tumor suppressor activ pkc isoform may aris abil downregul pdk akt phosphoactiv pip pdk akt mtor pathway link cell growth oncogenesi | D017346;D015398 | T043;T044;T116;T126 |
34,673,052 | ketamin enhanc novel object recognit memori reconsolid via bdnftrkb pathway mice addit antidepress properti ketamin subanesthet dose studi reveal ketamin influenc memori acquisit consolid reconsolid effect acut low dose ketamin administr condit memori investig extens rodent condit fear memori morphin induc condit place prefer contrast condit memori novel object recognit task assess natur format memori exploit rodent natur prefer novelti acut low dose ketamin administr impair acquisit consolid influenc reconsolid remain unclear investig issu well involv bdnftrkb pathway process administ ketamin ip mgkg immedi h reactiv without reactiv ana ip mgkg min ketaminevehicl administr ana select antagonist bdnf trkb receptor ketamin administr immedi rather without reactiv signific increas prefer index thus suggest enhanc memori reconsolid rather consolid ketamin exert signific effect administ h reactiv therebi suggest h effect time window ana administr signific reduc ketamin induc prefer index increas thus suggest blockag ketamin improv reconsolid howev blockag signific effect ketamin induc hippocamp bdnf level increas conclus acut low dose ketamin administr improv memori reconsolid increas hippocamp bdnf level subsequ bdnf bind trkb receptor | D007649;D020813 | T116;T121;T109;T192;T126 |
34,673,050 | longitudin atop dermat endotyp atop march paradigm includ black children atop march studi most white popul bias current paradigm | D001249;D003876;D005512;D065631 | T047;T046 |
34,673,048 | cannabinoid receptor engag promot group innat lymphoid cell expans enhanc airway hyperreact cannabinoid modul activ immun cell physiolog process lung group innat lymphoid cell ilc central player type asthma cannabinoid modul ilc activ remain elucid | D001249;D002186;D011014 | T050;T047;T121;T109 |
34,673,047 | socioeconom dispar asthma health care util exacerb mortal systemat review meta analysi prior studi investig effect socioeconom status ses asthma health care outcom heterogen popul studi methodolog use | D001249 | T047 |
34,673,046 | compar sensit face match assess detect face percept impair numer neurolog development psychiatr condit demonstr impair face recognit social debilit impair caus either defici face percept face memori mechan though well valid sensit measur face memori impair current remain unclear assess best measur face percept impair sensit valid face percept measur could help diagnos caus face recognit deficit use character individu differ unimpair popul compar computer benton face recognit test bfrt c cambridg face percept test cfpt abil differenti development prosopagnos dps n age match control n particip complet bfrt c cfpt two addit face percept assess univers southern california face percept test uscfpt novel samediffer face match test sdfmt particip also evalu object subject face recognit task includ cambridg face memori test famous face test prosopagnosia index perform logist regress percept test predict dp vs control group membership use multipl linear regress predict continu object subject face recognit memori result show bfrt c perform well better cfpt test clear outperform uscfpt sdfmt exploratori analys reveal face light chang condit better predict dp group membership face recognit abil viewpoint chang condit togeth result support combin use bfrt c cfpt best assess face percept impair | D000066499;D020238 | T048;T041 |
34,673,045 | pathway perceptu primaci erp evid relationship autism trait enhanc perceptu function autist individu show enhanc perceptu function mani behavior task neurophysiolog evid also support conclus autist individu util perceptu process greater extent neurotyp comparison support problem solv reason howev atyp earli perceptu process influenc subsequ cognit process remain elucid goal present studi test relationship earli perceptu subsequ cognit event relat potenti erp relationship level autism trait neurotyp adult complet autism spectrum quotient aq particip erp task path model compar test predict relationship among earli perceptu erp p compon subsequ cognit erp n effect attent detail subscal aq size particip p compon posit correl size n effect attent detail score model comparison support model specifi variat attent detail score predict meaning differ particip erp waveform relationship attent detail score size n effect signific mediat size p effect studi reveal neurotyp adult higher level attent detail show larger p differ turn correspond larger n effect find support enhanc perceptu function model autism suggest earli perceptu process differ may cascad forward result modif later cognit mechan | D000067877;D001321 | T048 |
34,673,044 | conidiobolus lunulus newli discov entomophthoralean speci pathogen specif leaf cutter ant conidiobolus lunulus recent describ entomophthoralean speci isol leaf cutter ant fungus discharg primari also secondari conidia microconidia differ shape noth known biolog fungus interact host first evalu pathogen leaf cutter ant chang fungal age time grown vitro relat conidi structur produc afterward test virul three combin temperatur relat humid addit note visibl caus death recov differ microorgan dead non steril ant evalu c lunulus virul pathogen carri natur ant present final use condit lead highest mortal evalu fungal virul host speci includ non leaf cutter ant result indic c lunulus pathogen cultur age day peak day old regist median lethal time day cadav fungal conidi result suggest primari conidia moon shape microconidia infect evalu mortal use day old cultur sever leaf cutter ant coloni show signific faster mortal c lunulus inocul ant comparison control signific greater faster mortal c c signific higher faster mortal rh signific reduct pathogen c lunulus inocul ant comparison control c lunulus high specif leaf cutter ant hard increas mortal observ inocul ant conidia record cadav three non leaf cutter ant speci test result highlight c lunulus promis biolog control agent leaf cutter ant | D054884 | T040 |
34,673,043 | reduc health environment impact chemic warfar agent comput chemistri contribut review articl summar advanc comput chemistri cheminformat method techniqu use potenti use reduc health environment impact chemic warfar agent cwa method includ limit predict model data mine virtual screen similar search molecular dock dynam briefli present applic silico approach specif protect personnel civilian cwa also beyond discuss cwa includ toxic chemic caus death injuri temporari incapacit chemic action cwa impos signific worldwid threat destruct remedi well protect measur need care design toward goal comput chemistri cheminformat play key role specif far decontamin risk assess risk manag concern among wide rang silico techniqu appli cwa specif previous publish paradigm present includ toxic properti predict cwa simul identif cwa detoxif beyond cwa research applic militari interest briefli present emerg trend potenti relev note | D002619 | T131 |
34,673,042 | occurr infant exposur assess per polyfluoroalkyl substanc breast milk south africa exposur infant per polyfluoroalkyl substanc pfas breast feed global concern owe numer detriment health effect studi investig occurr eleven perfluorocarboxyl acid pfcas four perfluorosulfon pfsas breast milk nurs mother south africa concentr pfas sampl measur use valid uhplc msms method median concentr pfas rang loq ng ml pfcas frequent detect breast milk pfsas howev perfluoropentano acid pfpea account total pfas concentr sampl median concentr pfuda pfdoa pftrda par pfoa estim feed frequenc infant sex birth weight gestat period strong correl bodi burden short long chain pfas breastmilk averag edi hq pfoa pfas pfoa pfna pfhxs pfos pfos present signific risk exclus breastf infant south africa result studi reflect widespread occurr short chain ie c long chain ie c c pfas provid preliminari data futur human biomonitor pfas persist organ pollut south africa inde african contin | D008895;D053719 | T031;T063 |
34,673,041 | investig antibacteri antifung antibiofilm antioxid anticanc properti methanol extract salvia marashica lim celep doan salvia caespitosa montbret aucher ex benth plant medicin import studi antimicrobi antifung antibiofilm activ test bacteria fungi salvia marashica lim celep doan salvia caespitosa montbret aucher ex benth speci perform agar well diffus microdilut method salvia speci show sensit zone diamet mm concentr mgml mgml dilut method use determin minimum inhibit concentr mic minimum bactericid concentr mbk mic valu plant most mgml mgml mbc valu mgml mgml antifung activ find remark speci observ high effect especi candida parapsilosi antioxid research find examin observ salvia marashica salvia caespitosa plant approxim antioxid activ mgml find most direct proport concentr antioxid activ capac record mcf huvec cell line use investig anticanc activ properti line find ic valu salvia marashica mcf cell line mgml mgml huvec cell line ic valu salvia caespitosa mcf cell line mgml huvec cell line found mgml proven salvia speci cytotox effect mcf cell line | D027544 | T002 |
34,673,039 | remedi heavi metal contamin iron ore tail appli compost grow perenni ryegrass lolium perenn l improp dispos heavi metal contamin iron ore tail pose signific risk surround environ ad compost grow ryegrass could cost effect long term solut remedi iron ore tail conduct glasshous studi investig impact compost amend ww growth accumul heavi metal cu fe mn pb ni zn shoot perenni ryegrass lolium perenn l grown two iron ore tail site site b mine pilbara western australia ryegrass harvest day sow site iron ore tail total concentr mg kg fe mn zn co site b mine tail total concentr mg kg fe ni zn tail low cation exchang capac organ matter air poros near neutral ph vari particl size distribut site clay loam site b sandi loam ryegrass germin higher extract site b site tail increas compost tail ratio increas dri shoot biomass day heavi metalmetalloid concentr shoot signific decreas increas compost tail ratio except cu zn bioconcentr factor bcf heavi metal metal concentr shoottot metal concentr substrat signific decreas increas proport compost growth substrat bcf zn cu heavi metal high concentr organ matter compost treatment like contribut enhanc mobilis cu zn plant uptak contrast compost stabilis metalsmetalloid tail decreas uptak ryegrass maintain plant growth despit relat high mn fe pb concentr iron ore tail | D000076282;D008129;D019216 | T167;T196;T002;T068 |
34,673,038 | hemp fiber modifi graphit oxid green effici solut water remedi applic methylen blue paper use hemp fiber modifi graphit oxid remov methylen blue mb aqueous solut investig paramet contact time ph temperatur initi concentr dye ionic strength vari effect adsorpt recoveri evalu adsorpt process attain equilibrium within min adsorpt capac found increas increas contact time experiment data fit pseudo second order model maximum adsorpt capac slight increas temperatur chang mgg mgg ph mgg mgg ph mgg mgg ph increas temperatur c c indic process slight endotherm h kjmol thermodynam paramet even calcul demonstr process spontan g jmol k jmol k final mathemat algorithm appli forecast respons surfac model second order model chosen fit experiment data statist effect process paramet estim numer optim even perform individu optim set process paramet ph c c mgl maxim remov capac possibl adsorpt mechan even present prove effici adsorpt novel inexpens sustain composit materi obtain agro wast resourc perform reusabl cycl | D002188;D006108;D014874;D018508 | T052;T121;T002;T109;T057;T167;T131;T196 |
34,673,037 | laboratori biomark multipl sclerosi ms multipl sclerosi ms neurolog diseas affect central nervous system cns diagnosi diseas quit challeng due variat among patient result need enhanc diagnost procedur evalu object prognost marker promot effect monitor patient respons treatment prompt identif mani biomark present date knowledg potenti biomark ms use assess diseas activ progress therapeut respons search articl conduct various databas name pubm cochran librari cinahl use ident search strategi term includ multipl sclerosi ms biomark potenti magnet reson spectroscopi progress marker predict disabl indic mass spectrometri prefer report item systemat review meta analysi prisma guidelin follow scrutin articl inclus studi search process identifi articl use systemat review ms biomark consist laboratori biomark imag biomark genet immunogenet biomark efficaci lead potenti classif reli numer factor sensit specif clinic rational predict practic biolog rational reproduc correl prognosi disabl oligoclon band ocb magnet reson imag mri featur establish biomark far although kappa free light chain kflcs measl rubella zoster mrz reaction neurofila light chain nfls might show potenti near futur studi conduct | D019411;D008279;D009103 | T047;T170;T060;T058;T033;T059 |
34,673,035 | concuss characterist earli postinjuri outcom colleg student intercollegi athlet describ concuss characterist among general colleg student compar postinjuri outcom intercollegi student athlet | D001265;D001924 | T037 |
34,673,032 | mediatori role central npi melanocortin corticotrophin system phoenixin induc hyperphagia neonat chicken anim research indic neuropeptid npi corticotrophin melanocortin system mediatori role reward howev substanc interact phenytoin pnx induc food intak bird remain identifi accord research eight test carri investig potenti interact npi melanocortin well corticotrophin system pnx food consumpt neonat chicken first experi chicken intracerebroventricular icv inject phosphat buffer salin pbs pnx nmol second experi pbs antagonist crf crf receptor astressin b g pnx astressin b inject rest experi chicken receiv astressin b crf receptor antagonist g shu mcr mcr receptor antagonist nomol mcl mcr receptor agonist nmol b npi receptor antagonist g sf npi receptor antagonist g sml npi receptor antagonist g rather astressin b cumul intak food record h base find pnx nmol led increment food consumpt compar control p co administr pnx astressin b promot pnx induc hyperphagia p co inject pnx astressin b potenti hyperphagia pnx p co inject pnx b inhibit effect pnx p co administr pnx sml potenti hypophag effect pnx p result show pnx induc hyperphagia mediat via npi npi crf crf receptor neonat chicken | D000324;D002645;D004435;D053486;D009478 | T116;T121;T123;T125;T012;T040;T033;T038 |
34,673,031 | phosphoryl regul arginin rich rna bind protein solubl oligomer posttransl modif ptms phosphoryl rna bind protein rbps regul sever critic step rna metabol includ spliceosom assembl altern splice mrna export notabl serin arginin sr rich rbps dens phosphoryl compar remaind proteom previous show dephosphoryl splice factor srsf regul increas interact similar arginin rich rbps u k lucl howev larg scale function structur impact modif rbps remain unclear work dephosphoryl nuclear extract use phosphatas vitro analyz equal amount deterg solubl insolubl fraction mass spectrometri base proteom correl network analysi resolv distinct modul differenti solubl nucleoplasm protein found class arginin rich rbps decreas solubl follow dephosphoryl enrich insolubl pellet fraction includ sr protein famili sr like lucl rbp famili import increas insolubl observ across broad class rbps determin phosphoryl regul srsf structur dephosphoryl srsf form high molecular weight oligomer speci vitro reciproc phosphoryl srsf serinearginin protein kinas srpk vitro decreas high molecular weight srsf speci format furthermor upon pharmacolog inhibit srpks mammalian cell observ srsf cytoplasm misloc increas format cytoplasm granul well cytoplasm tubular structur associ microtubul immunocytochem stain collect find demonstr phosphoryl may critic modif prevent arginin rich rbp insolubl oligomer | D055503 | T067 |
34,673,030 | perturb dimer interact alloster communic modul immunosuppress activ human galectin design alloster modul control protein function key object drug discoveri program alter function essenti alloster residu network provid uniqu protein famili subtyp specif minim unwant target effect help avert resist acquisit typic plagu drug target orthoster site work use protein engin dimer interfac mutat posit negat modul immunosuppress activ proapoptot human galectin gal use popmus beatmus algorithm mutat site residu ident comput probe predict either alter stabil gal dimer interfac design coval disulfid bridg protom control homodim strength stabil demonstr import dimer interfac perturb alloster network bridg two opposit glycan bind site gal result control induc apoptosi jurkat cell molecular investig gx gal variant use x ray crystallographi biophys comput character illumin residu involv dimer stabil alloster communic along discret long rang dynam behavior involv loop show perturb protein protein interfac gal protom modul biolog function even overal structur ligand bind affin remain unalt studi highlight new avenu design galectin specif modul influenc glycan depend glycan independ interact | D017209;D037161;D007108;D055503 | T116;T123;T043;T046;T067;T040 |
34,673,029 | black box discoveri sigma factor subunit structur e coli rna polymeras reflect articl focus year graduat student period made signific discoveri career written articl primarili protein biochemistri audienc colleagu share excit time scienc mani scientist last year contribut knowledg transcript machineri regul also written today graduat student postdoc scientist may know much discoveri technic advanc taken grant show even method primit today standard still abl make foundat advanc also hope provid glimps fortun graduat student year ago golden age molecular biolog | D012321;D004926;D029968;D012808 | T116;T007;T126;T123 |
34,673,028 | singl amino acid mutat mous meig protein disrupt cargo transport system necessari sperm format mammalian spermatogenesi high coordin process requir cooper specif protein coordin divers biolog function exampl mous parkin coregul gene pacrg recruit meiosi express gene meig manchett normal spermiogenesi mutat meig use crisprca system examin biolog physiolog consequ mice homozyg mutant male examin complet infertil sperm count dramat reduc develop sperm immotil display multipl abnorm histolog stain show impair spermiogenesi mutant mice immunofluoresc stain reveal mutant meig still present cell bodi spermatocyt also meig accumul acrosom region round spermatid mutant meig cargo protein meigpacrg complex sperm associ antigen l spagl longer found present manchett howev local pacrg compon chang mutant find demonstr meig key amino acid requir pacrg recruit meig manchett transport cargo protein sperm flagella format given meig pacrg conserv human small molecul block meigpacrg interact like ideal target develop male contraconcept drug | D020125 | T045 |
34,673,026 | covid relat burnout among healthcar worker india ecg base predict machin learn model insight bruce li studi covid pandem led unpreced increas rate stress burn among healthcar worker hcws heart rate variabl hrv shown reflect stress burnout present studi evalu preval burnout attempt develop hrv base predict machin learn ml model detect burnout among hcws covid pandem | D000086382 | T047;T067 |
34,673,025 | hydrogeochem characterist risk evalu potenti toxic element groundwat shanmughanadhi tamilnadu india hydrogeochem health risk assess trace element integr groundwat resourc assess util human health investig groundwat chemistri trace element impact local inhabit attempt shanmuganadhi basin tamilnadu india groundwat sampl collect pre monsoon period analyz hydrochem composit includ major trace element fe cr ni cu pb mn isol chemic characterist human health risk assess groundwat geochemistri prejud geochem reaction unit cation exchang dissolut precipit adsorpt anthropogen contribut thirti two percent groundwat sampl record higher f mgl prescrib limit suggest sourc rock weather silic dissolut nitrat mgl suggest sourc agricultur influenc water type indic alkali na k domin alkali earth ca mg strong acid cl loom weak acid co hco irrespect water sampl geochem stabil diagram suggest precipit silica carbon magnesium dissolut sulphat miner along groundwat flow path signific correl major ion trace element pb mn ni cu suggest origin rock weather human impact cultiv practic non carcinogen human risk trace element higher children compar adult via ingest dermal exposur carcinogen result suggest cr chk hbg excel chanc cancer risk environment risk categori attempt use comprehens risk factor cri suggest pb chk hbg potenti cancer risk comprehens evalu index recommend environment damag mild moder indic continu exposur traceabl element might result cancer caus inhabit studi suggest water qualiti seem prejud various geolog anthropogen caus endors counteract measur proper execut exist law protect groundwat resourc studi area | D060587;D014874 | T070;T082;T131;T081 |
34,673,024 | sleep disord breath hospit patient game changer sleep disord includ sleep apnea becom signific health issu unit state estim million american sleep apnea case moder sever osa go undiagnos number continu increas obes epidem sleep disord breath sdb associ multipl cardiopulmonari diseas shown affect diseas outcom advers hospit patient disproportion high preval cardiovascular respiratori diseas screen sdb hospit patient provid opportun identifi diseas individu whose diseas otherwis may go unrecogn data suggest identif sdb hospit individu may posit impact patient cours hospit unfortun sleep medicin current remain ambulatori practic hospit sleep medicin address separ herein discuss experi futur potenti hospit sleep medicin program | D012891 | T047 |
34,673,023 | chest infect lung transplant despit substanti progress long term follow strategi lung transplant recipi morbid mortal remain high most elev infecti risk develop chronic lung allograft dysfunct high immunosuppress level necessari prevent acut reject graft constant exposur environ come high price frequent infecti complic moreov infecti agent shown trigger acut reject chronic allograft dysfunct rapid diagnost approach follow earli treatment follow strategi paramount import howev challeng endeavor vast spectrum possibl pathogen discret clinic featur result form transplant recipi impair immun respons review propos stratifi diagnost strategi discuss relev pathogen correspond therapeut approach also offer insight infect prevent strategi vaccin prophylaxi pre emptiv therapi antibiot stewardship | D007239;D016040;D012141 | T047;T046;T061 |
34,673,022 | risk factor invas candida infect critic ill patient systemat review meta analysi current guidelin recommend empir antifung therapi patient sepsi high risk invas candida infect howev mani differ risk factor deriv multipl studi risk factor lack specif broad applic would render icu patient elig empir antifung therapi | D016638 | T047 |
34,673,021 | use fraction exhal nitric oxid measur clinic asthma manag asthma common heterogen diseas character lower airway inflamm airflow limit critic factor asthma manag includ establish accur diagnosi ensur appropri select dosag antiinflammatori therapi patient asthma exhibit type inflamm increas il il il signal often associ eosinophilia identifi lower airway eosinophilia sputum induct improv asthma outcom time consum cost increas type inflamm lead upregul nitric oxid releas airway increas fraction exhal feno reflect greater type inflamm feno measur easili quick clinic offer point care surrog measur degre lower airway inflamm feno test use help confirm asthma diagnosi guid inhal corticosteroid therapi assess adher treatment aid select appropri biolog therapi howev feno level also may influenc varieti intrins extrins factor asthma includ nasal polyposi cigarett smoke must interpret broader clinic context rather view isol review discuss clinic applic feno measur asthma care diagnosi treatment select describ place current intern expert guidelin | D001249;D000089142 | T047;T060;T201 |
34,673,020 | develop select fluoresc base enzym assay glycerophosphodiesteras famili member gde gde lysophosphatid acid lpa lipid mediat regul various process includ cell migrat cancer progress autotaxin atx lysophospholipas type exoenzym produc extracellular lpa contrast glycerophosphodiesteras gde famili member gde gde intracellular lysophospholipas form lpa depend mg ca respect sinc fluoresc substrat gdes report present studi examin whether fluoresc atx substrat fs could appli studi gde activ found membran fraction human gde gde overexpress human embryon kidney cell hydrolyz fs manner almost exclus depend mg ca respect use assay system found sever atx inhibitor includ bromomethylen phosphon analog lpa carbacycl phosphatid acid also potent inhibit gde gde activ contrast atx inhibitor hard inhibit activ furthermor fs hydrolyz mg depend manner membran fraction human prostat cancer lncap cell express gde endogen gde defici lncap cell similar ca depend gde activ observ human breast cancer mcf cell gde defici mcf cell final assay system could select measur gde gde activ mixtur membran fraction gde gde overexpress human embryon kidney cell presenc find allow high throughput assay gde gde activ could lead develop select inhibitor stimul well better understand biolog role enzym | D057075;D005453 | T070;T059 |
34,673,017 | singl cell rna sequenc bioinformat tool deciph cancer heterogen mechan drug resist well known cancer aggress diseas often associ relaps mani case due drug resist cancer stem cell clonal evolut frequent caus innat acquir drug resist current rna sequenc technolog distinguish gene express differ cell lineag base bulk cell studi singl cell rna sequenc technolog relat bioinformat cluster differenti express analysi repres turn point cancer research emerg essenti tool dissect tumor singl cell resolut repres novel tool understand carcinogenesi drug respons review outlin role new technolog address cancer heterogen cell lineag depend drug resist | D018740 | T032 |
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