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https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Idaho
This is a list of law enforcement agencies in the U.S. state of Idaho. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 117 law enforcement agencies employing 3,146 sworn police officers, about 206 for each 100,000 residents. State agencies Idaho Department of Correction Idaho Department of Juvenile Corrections Idaho Fish and Game Commission Idaho Conservation Officers Idaho State Police Idaho State Fire Marshal Idaho Weigh Station Division Idaho State Brand Inspector County agencies Ada County Sheriff's Office Adams County Sheriff's Office Bannock County Sheriff's Office Bear Lake County Sheriff's Office Benewah County Sheriff's Office Bingham County Sheriff's Office Blaine County Sheriff's Office Boise County Sheriff's Office Bonner County Sheriff's Office Bonneville County Sheriff's Office Boundary County Sheriff's Office Butte County Sheriff's Office Camas County Sheriff's Office Canyon County Sheriff's Office Caribou County Sheriff's Office Cassia County Sheriff's Office Clark County Sheriff's Office Clearwater County Sheriff's Office Custer County Sheriff's Office Elmore County Sheriff's Office Franklin County Sheriff's Office Fremont County Sheriff's Office Gem County Sheriff's Office Gooding County Sheriff's Office Idaho County Sheriff's Office Jefferson County Sheriff's Office Jerome County Sheriff's Office Kootenai County Sheriff's Office Latah County Sheriff's Office Lemh
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Illinois
This is a list of law enforcement agencies in the state of Illinois. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 877 law enforcement agencies employing 41,277 sworn police officers, about 321 for each 100,000 residents. State agencies Illinois Attorney General's Office Department of Investigations Illinois Attorney General Police Illinois Commerce Commission Police Illinois Department of Corrections Illinois Department of Human Services Police Department Illinois Department of Natural Resources Illinois Conservation Police Illinois Department of Revenue Police Bureau of Criminal Investigations Illinois Gaming Board Illinois Law Enforcement Training and Standards Board Illinois Secretary of State Illinois Secretary of State Capitol Police Illinois Secretary of State Police Illinois State Fire Marshal Arson Investigation Illinois State Police County agencies Sheriff's departments/offices Adams County Sheriff's Office Alexander County Sheriff's Office Bond County Sheriff's Office Boone County Sheriff's Office Brown County Sheriff's Office Bureau County Sheriff's Office Calhoun County Sheriff's Office Carroll County Sheriff's Office Cass County Sheriff's Office Champaign County Sheriff's Office Christian County Sheriff's Office Clark County Sheriff's Office Clay County Sheriff's Office Clinton County Sheriff's Office Coles County Sheriff's Office Cook County Sheri
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Indiana
This is a list of law enforcement agencies in the state of Indiana. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 482 law enforcement agencies employing 13,171 sworn police officers, about 206 for each 100,000 residents. Since 2012, the Indiana Law Enforcement Training Board (ILETB) has instituted a three-tier system of training for the state's various law enforcement agencies. Tier I: Full Basic Recruit Academy at one of the state's ILETB certified academies Tier II: Eight-week program held at the Indiana Law Enforcement Academy (ILEA) in Plainfield Tier III: Four-week program held at the ILEA in Plainfield Tier I State Agencies department Indiana Department of Natural Resources Law Enforcement Division Indiana Law Enforcement Academy Indiana Office of Inspector General Indiana State Excise Police Indiana State Fire Marshal's Office Indiana State Police Indiana State Police Capitol Police Section Commercial Vehicle Enforcement Division Tier II State Agencies Indiana Department of Correction Indiana Gaming Commission Office of Enforcement, Investigation, and Control Tier III State Agencies Indiana Attorney General's Office Medicaid Fraud Unit Indiana Secretary of State Securities Enforcement Division Tier I County Sheriff Agencies Tier I Municipal Police and Tier II Town Marshal Agencies Tier I College and University Police Agencies Anderson University Police Department Ball State Univ
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Iowa
This is a list of law enforcement agencies in the state of Iowa. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 392 law enforcement agencies employing 5,830 sworn police officers, about 195 for each 100,000 residents. Federal Agencies Office of the United States Marshal for the Northern District of Iowa Office of the United States Marshal for the Southern District of Iowa Department of Veterans Affairs State agencies Iowa Department of Corrections Division of Parole Iowa Department of Natural Resources Enforcement Iowa Department of Public Safety Iowa State Division of Criminal Investigation Iowa State Division of Narcotics Enforcement Iowa State Fire Marshal Iowa State Patrol County agencies Adair County Sheriff's Office Adams County Sheriff's Office Allamakee County Sheriff's Office Appanoose County Sheriff's Office Audubon County Sheriff's Office Benton County Sheriff's Office Black Hawk County Sheriff's Office Boone County Sheriff's Office Buchanan County Sheriff's Office Buena Vista County Sheriff's Office Butler County Sheriff's Office Calhoun County Sheriff's Office Carroll County Sheriff's Office Cass County Sheriff's Office Cedar County Sheriff's Office Cerro Gordo County Sheriff's Office Cherokee County Sheriff's Office Chickasaw County Sheriff's Office Clarke County Sheriff's Office Clay County Sheriff's Office Clayton County Sheriff's Office Clinton Co
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Kansas
This is a list of law enforcement agencies in the state of Kansas. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 371 law enforcement agencies employing 7,450 sworn police officers, about 266 for each 100,000 residents. State agencies Kansas Bureau of Investigation Kansas Department of Corrections Kansas Department of Revenue Kansas State Alcoholic Beverage Control Kansas Department of Wildlife, Parks and Tourism Kansas Highway Patrol Kansas State Fire Marshal Kansas Lottery Security & Law Enforcement Division (S.L.E.D.) Kansas Department of Labor Kansas Attorney General's Office County agencies Allen County Sheriff's Office Anderson County Sheriff's Office Atchison County Sheriff's Office Barber County Sheriff's Office Barton County Sheriff's Office Bourbon County Sheriff's Office Brown County Sheriff's Office Butler County Sheriff's Office Chase County Sheriff's Office Chautauqua County Sheriff's Office Cherokee County Sheriff's Office Cheyenne County Sheriff's Office Clark County Sheriff's Office Clay County Sheriff's Office Cloud County Sheriff's Office Coffey County Sheriff's Office Comanche County Sheriff's Office Cowley County Sheriff's Office Crawford County Sheriff's Office Decatur County Sheriff's Office Dickinson County Sheriff's Office Doniphan County Sheriff's Office Douglas County Sheriff's Office Edwards County Sheriff's Office Elk County Sherif
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Kentucky
This is a list of law enforcement agencies in the Commonwealth of Kentucky. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 389 law enforcement agencies employing 7,833 sworn police officers, about 183 for each 100,000 residents. State agencies Kentucky Department of Fish and Wildlife Resources Kentucky State Conservation Officers Kentucky Department of Parks Kentucky State Park Rangers Kentucky Horse Park Police Kentucky Justice and Public Safety Cabinet Kentucky Department of Corrections Kentucky Department of Juvenile Justice Kentucky State Police Division of Commercial Vehicle Enforcement Facilities Security Branch Kentucky Office of the Attorney General Kentucky Department of Criminal Investigation Kentucky Public Protection Cabinet Kentucky Department of Charitable Gaming Enforcement Kentucky Department of Alcoholic Beverage Control County agencies Adair County Sheriff's Office Adair County Constable Adair County Constable District 1 Adair County Constable District 2 Adair County Constable District 3 Adair County Constable District 4 Adair County Constable District 5 Adair County Constable District 6 Adair County Constable District 7 Allen County Sheriff's Office Allen County Constable Allen County Constable District 1 Allen County Constable District 2 Allen County Constable District 3 Allen County Constable District 4 Allen County Constable District 5 Anderson County
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Louisiana
This is a list of law enforcement agencies in Louisiana. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 348 law enforcement agencies employing 18,050 sworn police officers, about 405 for each 100,000 residents. This is the largest ratio of policemen to residents of any state and compares to a national average of 251 to 100,000. State agencies Louisiana Department of Children and Family Services Child Support Enforcement Louisiana Department of Environmental Quality Louisiana Department of Health and Hospitals Louisiana Medical Center Police Louisiana Department of Justice Louisiana Department of Public Safety Louisiana Division of Levee District Police Atchafalaya Basin Levee District Police Department East Jefferson Levee District Police Department Lafourche Basin Levee District Police Department Lake Borgne Levee District Police Department Orleans Levee District Police Department Pontchartrain Levee District Police Department Tensas Basin Levee District Police Department Louisiana State Fire Marshal Louisiana State Police Louisiana Department of Public Safety & Corrections Louisiana Department of Corrections - Adult Probation and Parole Division of Youth Services - Office of Juvenile Justice Louisiana Department of Revenue & Taxation Louisiana Alcoholic Beverage Control Louisiana Department of Transportation and Development Crescent City Connection Police Weight Enforcemen
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Maine
This is a list of law enforcement agencies in the state of Maine. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 146 law enforcement agencies employing 2,569 sworn police officers, about 195 for each 100,000 residents. State agencies Maine Department of Corrections Maine Department of Inland Fisheries and Wildlife Maine Warden Service Maine Department of Marine Resources Maine Marine Patrol Maine Department of Public Safety Maine Bureau of Capitol Police Maine Drug Enforcement Agency Maine State Fire Marshal's Office Maine State Police Maine Department of Agriculture, Conservation and Forestry Maine Forest Service Maine Department of the Secretary of State Bureau of Motor Vehicles Division of Enforcement, Anti-Theft and Regulations State of Maine Judicial Branch Office of Judicial Marshals Office of the Maine Attorney General Investigation Division County agencies Androscoggin County Sheriff's Office Aroostook County Sheriff's Office Cumberland County Sheriff's Office Franklin County Sheriff's Office Hancock County Sheriff's Office Kennebec County Sheriff's Office Knox County Sheriff's Office Lincoln County Sheriff's Office Oxford County Sheriff's Office Penobscot County Sheriff's Office Piscataquis County Sheriff's Office Sagadahoc County Sheriff's Office Somerset County Sheriff's Office Waldo County Sheriff's Office Washington County Sheriff's Office York County Sheriff's Of
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Maryland
This is a list of law enforcement agencies in the state of Maryland. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 142 law enforcement agencies employing 16,013 sworn police officers, about 283 for each 100,000 residents. State agencies Maryland Capitol Police Maryland Department of Health and Mental Hygiene Police Maryland Department of Labor Police Maryland Natural Resources Police Maryland Motor Vehicle Administration Police Department Maryland Office of the Comptroller Maryland State Police Maryland State Fire Marshal Maryland Transit Administration Police Maryland Transportation Authority Police Washington Suburban Sanitary Commission Police Department Maryland Department of Public Safety and Correctional Services County agencies Allegany County Sheriff's Office Anne Arundel County Police Department Anne Arundel County Sheriff's Office Baltimore County Police Department Baltimore County Sheriff's Office Calvert County Sheriff's Office Carroll County Sheriff's Office Caroline County Sheriff's Department Cecil County Sheriff's Office Charles County Sheriff's Office Dorchester County Sheriff's Office Frederick County Sheriff's Office Garrett County Sheriff's Office Harford County Sheriff's Office Howard County Police Department Howard County Sheriff's Office Kent County Sheriff's Office Montgomery County Police Department Montgomery County Sheriff's Office Prince George's County P
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Massachusetts
This is a list of law enforcement agencies in the Commonwealth of Massachusetts. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 357 law enforcement agencies employing 18,342 sworn police officers, about 280 for each 100,000 residents. Federal Agencies These are federal agencies that have common operations within the state. Administrative Office of the United States Courts, Office of Probation and Pretrial Services Amtrak Police Department Bureau of Alcohol, Tobacco, Firearms and Explosives Bureau of Industry and Security, Office of Export Enforcement Department of the Air Force Police Department of the Navy Police Drug Enforcement Administration Federal Air Marshal Service Federal Bureau of Investigation Federal Bureau of Prisons Federal Protective Service Internal Revenue Service, Criminal Investigations Division National Aeronautics and Space Administration, Protective Services National Oceanic and Atmospheric Administration Office of Law Enforcement National Park Service National Nuclear and Security Administration, Office of Secure Transport United States Air Force Office of Special Investigations United States Air Force Security Forces United States Army Military Police United States Coast Guard United States Customs and Border Protection United States Department of Veterans Affairs Police United States Diplomatic Security Service United States Environmental Protection Agency Criminal Investig
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Michigan
This is a list of law enforcement agencies in the state of Michigan. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 571 law enforcement agencies employing 19,009 sworn police officers, about 190 for each 100,000 residents. State agencies Michigan Department of Corrections Michigan Department of Natural Resources Michigan Conservation Officers Michigan State Police Regional agencies Central Michigan Enforcement Team CMAT Flint Area Narcotics Group FANG Huron Undercover Narcotics Team HUNT Livingston and Washtenaw Narcotics Enforcement Team LAWNET Metropolitan Enforcement Team MET Straits Area Narcotics Enforcement SANE State, Sheriffs, Chiefs Enforcement Team SSCENT Strike Team Investigative Narcotics Group STING Southwest Enforcement Team SWET Traverse Narcotics Team TNT Thumb Narcotics Unit TNU Tri County Metro Narcotics Tri-County Upper Peninsula Substance Enforcement Team UPSET West Michigan Enforcement Team WEMET County agencies Alcona County Sheriff's Office Alger County Sheriff's Office Allegan County Sheriff's Office Alpena County Sheriff's Office Antrim County Sheriff's Office Arenac County Sheriff's Office Baraga County Sheriff's Office Barry County Sheriff's Office Bay County Sheriff's Office Benzie County Sheriff's Office Berrien County Sheriff's Office Branch County Sheriff's Office Calhoun County Sheriff's Office Cass County Sheriff'
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Minnesota
This is a list of law enforcement agencies in the state of Minnesota. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 448 law enforcement agencies employing 9,667 sworn police officers, about 185 for each 100,000 residents. State agencies Minnesota Department of Corrections Minnesota Department of Natural Resources Law Enforcement Division Minnesota Department of Public Safety Minnesota Bureau of Criminal Apprehension Minnesota State Fire Marshal Minnesota Alcohol Gambling Enforcement Division Minnesota State Patrol Capitol Security Minnesota Department of Commerce Fraud Bureau Minnesota National Guard Dept. of Military Affairs Security Police Military Police 34th Military Police Company 257th Military Police Company Security Forces 148th Security Forces Squadron 133rd Security Forces Squadron Phoenix Raven Team County agencies Aitkin County Sheriff's Office Anoka County Sheriff's Office Becker County Sheriff's Office Beltrami County Sheriff's Office Benton County Sheriff's Office Big Stone County Sheriff's Office Blue Earth County Sheriff's Office Brown County Sheriff's Office Carlton County Sheriff's Office Carver County Sheriff's Office Cass County Sheriff's Office Chippewa County Sheriff's Office Chisago County Sheriff's Office Clay County Sheriff's Office Clearwater County Sheriff's Office Cook County Sheriff's Office Cottonwood County Sheriff's Office Crow Wing County Sheri
https://en.wikipedia.org/wiki/Ulsan%20Airport
Ulsan Airport is an airport in Ulsan, South Korea. In 2018, 817,341 passengers used the airport. Airlines and destinations Statistics Facility Passenger Terminal: 8,651 m2 Runway: Direction= 18/36 ; Length x Width = 2000 m x 45 m Apron: 3,480 m2 (Four B737s can be parked simultaneously.) Ground Transportation Bus 102, 111, 122, 203, 205, 216, 225, 235, 236, 256, 266, 402, 412, 422, 432, 442, 453, 702, 714, 732, 1127, 5005 (to KTX Ulsan Station) References External links Ulsan Airport (in English) Ulsan's Travelguide Airports in South Korea Airports established in 1970 1970 establishments in South Korea 20th-century architecture in South Korea
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Mississippi
This is a list of law enforcement agencies in the state of Mississippi. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 342 law enforcement agencies employing 7,707 sworn police officers, about 262 for each 100,000 residents. Per the state constitution, all "civil officers" of the state, including those in the legislative and judicial branches, can exercise the power of arrest, though this is rarely exercised by said officials. Multi-County agencies Metro Narcotics Unit (Oxford and Layfette Counties and the University of Mississippi) State agencies Mississippi Attorney General's Office Mississippi Bureau of Investigation Mississippi Bureau of Narcotics Mississippi Capitol Police Mississippi Department of Corrections Mississippi Department of Revenue Criminal Investigations Division Alcoholic Beverage Control Mississippi Department of Wildlife, Fisheries and Parks Law Enforcement Division Mississippi Highway Patrol Mississippi Department of Transportation Office of Law Enforcement Mississippi Reservoir Police Mississippi Gaming Commission Mississippi Agricultural & Livestock Theft Bureau Mississippi Department of Human Services | Office of Inspector General | Bureau of Investigation School district agencies North Bolivar Consolidated Schools School Safety Hazlehurst City School District Safety and Security Department Hattiesburg Public Schools Police Department Petal School P
https://en.wikipedia.org/wiki/Yeosu%20Airport
Yeosu Airport is an airport in Yeosu, South Korea . In 2018, 590,112 passengers used the airport. Airlines and destinations Statistics Ground transportation City Bus No. 31, 32, 33, 34, 35, 96 References Yeosu Airport (in English) Airports in South Korea Yeosu Airports established in 1972 1972 establishments in South Korea 20th-century architecture in South Korea
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Missouri
This is a list of law enforcement agencies in the state of Missouri. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 576 law enforcement agencies employing 14,554 sworn police officers, about 244 for each 100,000 residents. State agencies Missouri Department of Conservation Protection Division Missouri Department of Corrections Missouri Department of Natural Resources Missouri State Park Rangers Missouri Department of Public Safety Missouri Gaming Commission Missouri Homeland Security Missouri State Capitol Police Missouri State Emergency Management Agency Missouri State Fire Marshal Investigation Unit Missouri State Highway Patrol Missouri State Water Patrol Missouri State Marshal County agencies Adair County Sheriff's Office Andrew County Sheriff's Office Atchison County Sheriff's Office Audrain County Sheriff's Office Barry County Sheriff's Office Barton County Sheriff's Office Bates County Sheriff's Office Benton County Sheriff's Office Bollinger County Sheriff's Office Boone County Sheriff's Office Buchanan County Sheriff's Office Butler County Sheriff's Office Caldwell County Sheriff's Office Callaway County Sheriff's Office Camden County Sheriff's Office Cape Girardeau County Sheriff's Office Carroll County Sheriff's Office Carter County Sheriff's Office Cass County Sheriff's Office Cedar County Sheriff's Office Chariton County Sheriff's Office Christian County Sheriff's Off
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Montana
This is a list of law enforcement agencies in the state of Montana. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 119 law enforcement agencies employing 3,229 sworn police officers, about 201 for each 100,000 residents. State agencies Montana Department of Corrections Montana Department of Justice Montana Highway Patrol Division of Criminal Investigations Gambling Control Division Investigation Bureau Montana Department of Livestock Brands Enforcement Division Montana Department of Fish, Wildlife, and Parks Law Enforcement Bureau Montana Department of Transportation Motor Carrier Services Enforcement Bureau County agencies Beaverhead County Sheriff's Office Big Horn County Sheriff's Office Blaine County Sheriff's Office Broadwater County Sheriff's Office Carbon County Sheriff's Office Carter County Sheriff's Office Cascade County Sheriff's Office Chouteau County Sheriff's Office Custer County Sheriff's Office Daniels County Sheriff's Office Dawson County Sheriff's Office Fallon County Sheriff's Office Fergus County Sheriff's Office Flathead County Sheriff's Office Gallatin County Sheriff's Office Garfield County Sheriff's Office Glacier County Sheriff's Office Golden Valley County Sheriff's Office Granite County Sheriff's Office Hill County Sheriff's Office Jefferson County Sheriff's Office Judith Basin County Sheriff's Office Lake County Sheriff's Office Lewis and Clark County Sheriff's Office L
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Nebraska
This is a list of law enforcement agencies in the state of Nebraska. According to the U.S. Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 225 law enforcement agencies employing 3,765 sworn officers, about 211 for each 100,000 residents. State agencies Nebraska Brand Committee Nebraska Department of Agriculture — responsible for enforcement of the Nebraska Pesticide Act Nebraska Department of Insurance - Insurance Fraud Prevention Division Nebraska Department of Motor Vehicles, Driver & Vehicle Records Division, Fraud Investigation Section - "performs investigative work relating to vehicle title and registration fraud, driver's license fraud, and odometer fraud. Motor Vehicle Fraud Investigators are certified Nebraska Law Enforcement Officers commissioned as Deputy State Sheriffs." Nebraska Department of Revenue Nebraska Emergency Management Agency - Homeland Security Nebraska Game and Parks Commission - conservation officers enforce Nebraska wildlife laws Nebraska Law Enforcement Training Center Nebraska Public Service Commission - Transportation Investigators Nebraska State Fire Marshal Nebraska State Patrol Nebraska State Racing Commission University of Nebraska at Kearney Police Department University of Nebraska at Lincoln Police Department University of Nebraska at Omaha Police Department County agencies Adams County Sheriff's Department Antelope County Sheriff's Office Arthur County Sheriff's Office Banner County
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20New%20Hampshire
This is a list of law enforcement agencies in the state of New Hampshire. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 208 law enforcement agencies employing 2,936 sworn police officers, about 222 for each 100,000 residents. State agencies New Hampshire Administrative Office of Courts, Security Department New Hampshire Liquor Commission Division of Enforcement New Hampshire Department of Corrections New Hampshire Department of Safety Division of Fire Safety (Office of State Fire Marshal) Division of State Police Field Operations Bureau New Hampshire Marine Patrol State Office Complex Police New Hampshire Fish and Game Department Law Enforcement Division New Hampshire Office of the Attorney General Criminal Justice Bureau New Hampshire Department of Natural and Cultural Resources Division of Forests and Lands Forest Protection Bureau County agencies Belknap County Sheriff's Office Carroll County Sheriff's Office Cheshire County Sheriff's Department Coös County Sheriff's Office Grafton County Sheriff's Office Hillsborough County Sheriff's Office Merrimack County Sheriff's Office Rockingham County Sheriff's Office Strafford County Sheriff's Office Sullivan County Sheriff's Office Municipal agencies Belknap County Alton Police Department Barnstead Police Department Belmont Police Department Center Harbor Police Department Gilford Police Department Gilmanton Polic
https://en.wikipedia.org/wiki/Terminal%20nerve
The terminal nerve, also known as cranial nerve 0 or simply as CN 0, is a nerve that was not included in the seminal classification of the cranial nerves as CN I through CN XII but is now generally classified as a cranial nerve. It was discovered by German scientist Gustav Fritsch in 1878 in the brains of sharks. It was first found in humans in 1913. A 1990 study has indicated that the terminal nerve is a common finding in the adult human brain. The nerve has been called unofficially by other names, including cranial nerve XIII, zero nerve, nerve N, and NT. Structure The terminal nerve appears just anterior of the other cranial nerves bilaterally as a microscopic plexus of unmyelinated peripheral nerve fascicles in the subarachnoid space covering the gyrus rectus. This plexus appears near the cribriform plate and travels posteriorly toward the olfactory trigone, medial olfactory gyrus, and lamina terminalis. The nerve is often overlooked in autopsies because it is unusually thin for a cranial nerve, and is often torn out upon exposing the brain. Careful dissection is necessary to visualize the nerve. Its purpose and mechanism of function is still open to debate; consequently, nerve zero is often not mentioned in anatomy textbooks. Development The zebrafish was used as a developmental model in research from 2004. The connections between the terminal nerve and the olfactory system have been extensively studied in human embryos. It was found to enter the brain at stages 17
https://en.wikipedia.org/wiki/Inotuzumab%20ozogamicin
Inotuzumab ozogamicin, sold under the brand name Besponsa, is an antibody-drug conjugate medication used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). The medication consists of a humanized monoclonal antibody against CD22 (inotuzumab), linked to a cytotoxic agent from the class of calicheamicins called ozogamicin. This drug was discovered by scientists collaborating at Celltech and Wyeth, and it was developed by Pfizer which had acquired Wyeth. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Medical use Inotuzumab ozogamicin is used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia. It is administered by intravenous infusion in a doctor's office or clinic. In studies in pregnant animals, the drug caused harm to the fetus at doses less than those used clinically, and so the drug has not been tested in pregnant women. Pregnant women should not take inotuzumab ozogamicin and must not become pregnant while taking it. It is unknown if the drug or its metabolites are secreted in breast milk, but women should not breastfeed while taking it, and should wait two months after the last dose to start breastfeeding. The drug prolongs the QT interval in some people, so it should be used with caution in people with heart arrhythmias. Adverse effects The US label for the use of inotuzumab ozagamicin carries an FDA black box warning concerning the risk of liver toxicity, in
https://en.wikipedia.org/wiki/Tucotuzumab%20celmoleukin
Tucotuzumab celmoleukin is an anti-cancer drug. It is a fusion protein of a humanized monoclonal antibody (tucotuzumab) and an interleukin-2 (celmoleukin). This drug was developed by EMD Pharmaceuticals. References Monoclonal antibodies for tumors Antibody-drug conjugates
https://en.wikipedia.org/wiki/Parkland%20formula
The Parkland formula, also known as Baxter formula, is a burn formula developed by Charles R. Baxter, used to estimate the amount of replacement fluid required for the first 24 hours in a burn patient so as to ensure the patient is hemodynamically stable. The milliliter amount of fluid required for the first 24 hours – usually Lactated Ringer's – is four times the product of the body weight and the burn percentage (i.e. body surface area affected by burns). The first half of the fluid is given within 8 hours from the burn incident, and the remaining over the next 16 hours. Only area covered by second-degree burns or greater is taken into consideration, as first-degree burns do not cause hemodynamically significant fluid shift to warrant fluid replacement. The Parkland formula is mathematically expressed as: where mass (m) is in kilograms (kg), area (A) as a percentage of total body surface area, and volume (V) is in milliliters (mL). For example, a person weighing 75 kg with burns to 20% of his or her body surface area would require 4 x 75 x 20 = 6,000 mL of fluid replacement within 24 hours. The first half of this amount is delivered within 8 hours from the burn incident, and the remaining fluid is delivered in the next 16 hours. The burn percentage in adults can be estimated by applying the Wallace rule of nines (see total body surface area): 9% for each arm, 18% for each leg, 18% for the front of the torso, 18% for the back of the torso, and 9% for the head and 1% for
https://en.wikipedia.org/wiki/Kapustinskii%20equation
The Kapustinskii equation calculates the lattice energy UL for an ionic crystal, which is experimentally difficult to determine. It is named after Anatoli Fedorovich Kapustinskii who published the formula in 1956. {| |- |where ||K = 1.20200 J·m·mol−1 |- | ||d = 3.45 m |- | ||ν is the number of ions in the empirical formula, |- | || z+ and z− are the numbers of elementary charge on the cation and anion, respectively, and |- | || r+ and r− are the radii of the cation and anion, respectively, in meters. |} The calculated lattice energy gives a good estimation for the Born–Landé equation; the real value differs in most cases by less than 5%. Furthermore, one is able to determine the ionic radii (or more properly, the thermochemical radius) using the Kapustinskii equation when the lattice energy is known. This is useful for rather complex ions like sulfate (SO) or phosphate (PO). Derivation from the Born–Landé equation Kapustinskii originally proposed the following simpler form, which he faulted as "associated with antiquated concepts of the character of repulsion forces". Here, K' = 1.079 J·m·mol−1. This form of the Kapustinskii equation may be derived as an approximation of the Born–Landé equation, below. Kapustinskii replaced r0, the measured distance between ions, with the sum of the corresponding ionic radii. In addition, the Born exponent, n, was assumed to have a mean value of 9. Finally, Kapustinskii noted that the Madelung constant, M, was approximately 0.88
https://en.wikipedia.org/wiki/Padina
Padina may refer to: Geography In Bulgaria Padina, Kardzhali Province Padina, Silistra Province Padina, Varna Province In Romania Padina, Buzău, a commune in Buzău County Padina, a village in Amărăști Commune, Vâlcea County Padina, a tributary of the river Lotru in Vâlcea County Padina Șirnii River, a headwater of the Padina Dâncioarei River, a headwater of the Dâmbovicioara River In Serbia Padina (Kovačica), a Slovak-populated village in the region of Banat, Vojvodina Padina (Merošina), a village in Nišava District Padina (Belgrade), an urban neighborhood of Belgrade, in the municipality of Zvezdara As a part of the name In Antarctica Kresnenska Padina, a depression in Perunika Glacier in eastern Livingston Island In Romania Pădina Mare, a commune in Mehedinţi County, and its village of Pădina Mică In Serbia Sunčana Padina, an urban neighborhood of Belgrade, in the municipality of Čukarica Čukarička Padina, an urban neighborhood of Belgrade, in the municipality of Čukarica Vidikovačka Padina, a part of the urban neighborhood of Vidikovac in Belgrade Other Padina (alga), a genus of brown algae
https://en.wikipedia.org/wiki/Sorbitol%20dehydrogenase
Sorbitol dehydrogenase (or SDH) is a cytosolic enzyme. In humans this protein is encoded by the SORD gene. Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+ --> fructose + NADH + H+. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in various organisms from bacteria to humans. A secondary use is the metabolism of dietary sorbitol, though sorbitol is known not to be absorbed as well in the intestine as its related compounds glucose and fructose, and is usually found in quite small amounts in the diet (except when used as an artificial sweetener). Structure The structure of human sorbitol dehydrogenase was determined through crystallization experiments and X-ray diffraction (with a resolution of 2.20 Å). The method used for crystallization was “Vapor Diffusion, Hanging Drop” at pH 6.2 and at a temperature of 295.0 K. Sorbitol dehydrogenase consists of four identical chains (A, B, C, D), each of which being 31% helical (14 helices) and 26% beta sheet (23 strands). MolProbity Ramachandran analysis was conducted by Lovell, Davis, et al. The results were that 97.1% of all residues were in favored regions and 100.0% of a
https://en.wikipedia.org/wiki/Galectin
Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown. Structure There are three different forms of galectin structure: dimeric, tandem or chimera. Dimeric galectins, also called prototypical galectins, are homodimers, consisting of two identical galectin subunits t
https://en.wikipedia.org/wiki/KLRD1
CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene. The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells. Function Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence. Interactions KLRD1 has been shown to interact with KLRC2. See also Cluster of differentiation CD94/NKG2 References Further reading External links Clusters of differentiation C-type lectins
https://en.wikipedia.org/wiki/Mexazolam
Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. Its principal active metabolites are chlorodesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan). See also Benzodiazepine Delorazepam Lorazepam References Chloroarenes GABAA receptor positive allosteric modulators Lactams Oxazolobenzodiazepines
https://en.wikipedia.org/wiki/Gamma-glutamyl%20carboxylase
Gamma-glutamyl carboxylase is an enzyme that in humans is encoded by the GGCX gene, located on chromosome 2 at 2p12. Function Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational modification. In humans, the gamma-glutamyl carboxylase enzyme is most highly expressed in the liver. Catalytic reaction Gamma-glutamyl carboxylase oxidizes Vitamin K hydroquinone to Vitamin K 2,3 epoxide, while simultaneously adding CO2 to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also called gamma-carboxyglutamate, abbreviation = Gla). Presence of two carboxylate groups causes chelation of Ca2+ , resulting in change in tertiary structure of protein and its activation. The carboxylation reaction will only proceed if the carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time; the carboxylation and epoxidation reactions are said to be coupled reactions. No experimental structure is known for GGCX, limiting understanding of its reaction mechanism. Based on the fact that the two reactions are coupled, a computational study is able to propose how the reactants interact with each other to form the products. Lys228 h
https://en.wikipedia.org/wiki/Complement%20component%204
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia. The C4 protein was thought to derive from a simple two-locus allelic model, which however has been replaced by a much more sophisticated multimodular RCCX gene complex model which contain long and short forms of the C4A or C4B genes usually in tandem RCCX cassettes with copy number variation, that somewhat parallels variation in the levels of their respective proteins within a population along with CYP21 in some cases depending on the number of cassettes and whether it contains the functional gene instead of pseudogenes or fragments. Originally defined in the context of the Chido/Rodgers blood group system, the C4A-C4B genetic model is under investigation for its possible role in schizophrenia risk and development. History One of the earlier genetic studies on the C4 protein identified two different groups, found within a human serum, calle
https://en.wikipedia.org/wiki/Chymase
Chymases (, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8). Recently, Derakhshan et al. reported that a specific mast cell population expressed transcripts for Mcpt8. They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by connective tissue-type mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response, and chymase mcp1 and mcp2 are used for marker for mast cell degranulation in parasite infection such as Nematode, Trichuris muris Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis. Because of its role in inflammation it has been investigated as a target in the treatment of asthma. References EC 3.4.21
https://en.wikipedia.org/wiki/Myeloblastin
Myeloblastin (, leukocyte proteinase 3, leukocyte proteinase 4, Wegener's granulomatosis autoantigen, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme. This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val- This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation. See also Proteinase 3 References External links EC 3.4.21
https://en.wikipedia.org/wiki/Pronase
Pronase is a commercially available mixture of proteases isolated from the extracellular fluid of Streptomyces griseus. Activity extends to both denatured and native proteins leading to complete or nearly complete digestion into individual amino acids. One site that it cleaves at is the inactivation gate of Na+ voltage gated ion channels in neurons. Pronase is under investigation as a way to improve image quality in gastroscopy by thinning the mucus in advance. See also Proteinase K References External links EC 3.4.24
https://en.wikipedia.org/wiki/Batroxobin
Batroxobin, also known as reptilase, is a snake venom enzyme with Venombin A activity produced by Bothrops atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America. It is a hemotoxin which acts as a serine protease similarly to thrombin, and has been the subject of many medical studies as a replacement of thrombin. Different enzymes, isolated from different species of Bothrops, have been called batroxobin, but unless stated otherwise, this article covers the batroxobin produced by B. moojeni, as this is the most studied variety. History Bothrops atrox was described by Carl Linnaeus as early as 1758, but batroxobin, the active compound in its venom, was first described only in 1954 by H. Bruck and G. Salem. In the years following, this first description of batroxobin was shown to have several uses in surgery. Because of the increasing interest in the properties of batroxobin, several studies on its hemostatic effect and coagulation have been published. More recently, in 1979, a German study showed the uses of batroxobin (reptilase clot retraction test) as a replacement test for the more commonly used thrombin time. Because the enzyme is unaffected by heparin, it is mostly used when heparin is present in blood. Recent studies emphasize more on improving its uses in surgery, mostly spinal surgery, and the uses as serine protease. Available forms Batroxobin is a protein of the serine protease family. Batroxobin is closely related in phy
https://en.wikipedia.org/wiki/Romanian%20Figure%20Skating%20Championships
The Romanian Figure Skating Championships is a figure skating competition held annually to crown the national championships of Romania. Medalists *: Results were taken from that season's Crystal Skate of Romania competition. Men Ladies Pairs References External links Romanian Skating Federation historic results Figure skating national championships Figure skating in Romania Figure Skating
https://en.wikipedia.org/wiki/IKBKG
NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on the chromosome band Xq28. Multiple transcript variants encoding different isoforms have been found for this gene. Function NEMO (IKK-γ) is the regulatory subunit of the inhibitor of IκB kinase (IKK) complex, which activates NF-κB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Clinical significance Mutations in the IKBKG gene results in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Incontinentia Pigmenti (IP) is an X-linked dominant disease caused by a mutation in the IKBKG gene. Since IKBKG helps activate NF-κB, which protects cells against TNF-alpha induced apoptosis, a lack of IKBKG (and hence a lack of active NF-κB) makes cells more prone to apoptosis. Moreover, NEMO has been shown to play a role in preeclampsia and may offer insights into the genetic etiology of this condition. An increased level of NEMO gene expression was found in the blood of pregnant women with preeclampsia and their children. However, a decrease of the mRNA levels of total NEMO and the transcripts 1A, 1B, and 1C in placentas derived from preeclamptic women may be the main reason for intensified apopt
https://en.wikipedia.org/wiki/Fenretinide
Fenretinide (N-(4-hydroxyphenyl)retinamide; 4-HPR) (INN) is a synthetic retinoid derivative. Retinoids are substances related to vitamin A. It has been investigated for potential use in the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in Stargardt's patients. In cancer studies, Fenretinide treatment may cause ceramide (a wax-like substance) to build up in tumor cells and is associated with the accumulation of reactive oxygen species (ROS), resulting in cell death through apoptosis and/or necrosis. Fenretinide accumulates preferentially in fatty tissue such as the breast, which may contribute to the effectiveness of fenretinide against breast cancer. Phase III clinical trial data has suggested that fenretinide reduces breast cancer relapse in pre-menopausal women. Common side effects associated with fenretinide treatment include skin dryness and night-blindness, which is reversible upon cessation of treatment. Specific types of cancer under investigation include or have included ovarian, prostate, cervical, lung, renal, bladder, breast, glioma, skin, head and neck carcinoma, non-Hodgkin's lymphoma, neuroblastoma, and Ewing's sarcoma. References External links Numerous references and links to current and past clinical trials and studies of fenretinide can be found at the Journal of Clinical Oncology website
https://en.wikipedia.org/wiki/Lymphocyte%20cytosolic%20protein%202
Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a signal-transducing adaptor protein expressed in T cells and myeloid cells and is important in the signaling of T-cell receptors (TCRs). As an adaptor protein, SLP-76 does not have catalytic functions, primarily binding other signaling proteins to form larger signaling complexes. It is a key component of the signaling pathways of receptors with immunoreceptor tyrosine-based activation motifs (ITAMs) such as T-cell receptors, its precursors, and receptors for the Fc regions of certain antibodies. SLP-76 is expressed in T-cells and related lymphocytes like natural killer cells. Structure and function The amino acid sequence of the protein has a central domain with a high concentration of prolines, as well as domains at the amino-terminal and carboxy-terminal of the amino acid sequence. The PDB file 1H3H depicts the SH3 domain of GRAP2 in complex with an RSTK-containing peptide representing residues 226–235 of SLP-76. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains. The central domain binds SRC-Homology 3 (SH3) domains of other adaptor molecules such as Grb2 and Gads. The N-terminus has an acidic region with sections for SH2-domain binding and tyrosine residues that bind the proteins Vav and Nck when phosphorylated. The C-terminus region is itself a SH2 domain and binds FYB among other p
https://en.wikipedia.org/wiki/Numbered%20highways%20in%20New%20York
The New York State Department of Transportation (NYSDOT) is responsible for the establishment and classification of a state highway network which includes Interstate Highways, U.S. Highways, and state routes. U.S. and Interstate Highways are classified as state routes in New York; however, a letter ("U" or "I", respectively) is suffixed to the number of the route. As a result, there is apparent duplication between U.S. Routes, Interstate Highways and state routes. The New York state highway system is supplemented by the state's county route system, which comprises a series of highways numbered and maintained by the individual county highway departments. While neighboring New Jersey employs a statewide numbering system, no such system exists in New York. Instead, each county numbers its highways independently of other counties. As a result, county routes typically change numbers when they cross county lines. In some cases, the state highway and county highway systems overlap. More specifically, some portions of U.S. Routes and state routes in New York are signed as U.S. Routes or state routes but are maintained by the county that the route lies within. These county-maintained segments also carry a county route designation that may or may not be posted alongside the U.S. or state designation, depending on the signing practices of the county. Some state routes, such as New York State Route 148 in Niagara County, are entirely county-maintained. History Lists of routes Thruwa
https://en.wikipedia.org/wiki/Hydroxysteroid%20dehydrogenase
Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs). There are four types, classified by the number of the position acted upon: See also Steroidogenic enzyme Steroid hydroxylase External links EC 1.1.1
https://en.wikipedia.org/wiki/Ofatumumab
Ofatumumab is a fully human monoclonal antibody to CD20, which appears to provide rapid B-cell depletion. Under the brand name Kesimpta, it is approved for the treatment of multiple sclerosis in the United States as well as in the European Union and other regions. Under the brand name Arzerra, it is approved for the treatment of certain types of chronic lymphocytic leukemia (CLL) in the United States. It is sold by Novartis under license from Genmab. The most common side effects for ofatumumab (Kesimpta) include upper respiratory tract infection, headache, injection-related reactions, and local injection site reactions. The most common side effects for ofatumumab (Arzerra) include infusion reactions and neutropenia. Medical uses Ofatumumab (Kesimpta 20 mg solution for injection in pre-filled syringe/pen) is indicated for the treatment of relapsing forms of multiple sclerosis in adults. The recommended dose is 20 mg of ofatumumab administered by subcutaneous injection with monthly dosing following loading. Treatment with ofatumumab has been shown to rapidly deplete B-cells which aids MS pathogenesis by influencing and regulating different autoimmune process such as T-cell production and APC activity. Depleted B-cells are required to address chronic clinical conditions like MS. Ofatumumab (Arzerra 100 mg or 1000 mg concentrate for solution for infusion) is indicated for the treatment of untreated, relapsed, or refractory chronic lymphocytic leukemia (CLL). The recommended d
https://en.wikipedia.org/wiki/Channel-inducing%20factor%204
Channel-inducing factor is a regulatory protein for aldosterone receptors. See also Chromosome 10 (human) FXYD family External links
https://en.wikipedia.org/wiki/Annexin%20A1
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Function Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 Dalton and are preferentially located on the cytosolic face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. Clinical significance Effect on innate and adaptive immunity Glucocorticoids (such as budesonide, cortisol, and beclomethasone) are a class of endogenous or synthetic anti-inflammatory steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. They are used in medicine to treat diseases caused by an overactive immune system, including allergies, asthma, autoimmune diseases, and sepsis. Because they suppress inflammatory pathways, long-term use of glucocorticoid drugs can lead to side-effects such as immunodeficiency and adrenal insufficiency. The main mechanism of glucocorticoids' anti-inflammatory effects is to increase the synthesis and function of annexin A1. Annexin A1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events (epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, etc.). In other words, glucocorticoids not only suppress immune response, but also inhibi
https://en.wikipedia.org/wiki/Annexin%20A2
Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body. Gene The ANXA2 gene, located at 15q22.2, has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Function This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors. Maternal deficiency of the ANXA2 gene contributes to shallow decidual invasion by placental cytotrophoblast cells. These findings highlight the maternal contribution to the pathogenesis of severe pr
https://en.wikipedia.org/wiki/Labetuzumab
Labetuzumab (marketed under the trade name CEA-CIDE) is a humanized IgG1 monoclonal antibody for the treatment of colorectal cancer. It selectively binds to carcinoembryonic cell adhesion molecule 5. Also tried in patients with MTC (medullary thyroid carcinoma) with metastasis. This drug was developed by Immunomedics, Inc. References Monoclonal antibodies for tumors
https://en.wikipedia.org/wiki/Annexin%20A5
Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments. Pathology Antibodies directed against annexin A5 are found in patients with a disease called the antiphospholipid syndrome (APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin A5 forms a shield around negatively charged phospholipid molecules. The formation of an annexin A5 shield blocks the entry of phospholipids into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of the shield is disrupted by antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the blood-clotting characteristic of the antiphospholipid antibody syndrome. Annexin A5 showed upregulation in papillary thyroid carcinoma. Laboratory use Annexin A5 is used as a non-quantitative probe to detect cells that have expressed phosphatidylserine (PS) on the c
https://en.wikipedia.org/wiki/Detumomab
Detumomab is a mouse monoclonal antibody targeting human B-cell lymphoma. References Monoclonal antibodies for tumors
https://en.wikipedia.org/wiki/Mitumomab
Mitumomab (BEC-2) is a mouse anti-BEC-2 monoclonal antibody investigated for the treatment of small cell lung carcinoma in combination with BCG vaccination. Mitumomab attacks tumour cells, while the vaccine is thought to activate the immune system. It was developed by ImClone and Merck. The first phase III clinical trial began in 1998. In 2005 and again in 2008, results were published showing no benefit to patients receiving mitumomab and BCG. See also Anti-ganglioside antibodies References Monoclonal antibodies for tumors Experimental cancer drugs Abandoned drugs
https://en.wikipedia.org/wiki/Taplitumomab%20paptox
Taplitumomab paptox is a mouse monoclonal antibody. The antibody itself, taplitumomab, is linked to the protein PAP, an antiviral from Phytolacca americana, a species of pokeweed. This is reflected by the 'paptox' in the drug's name. References Monoclonal antibodies for tumors Antibody-drug conjugates Experimental cancer drugs
https://en.wikipedia.org/wiki/LDL-receptor-related%20protein-associated%20protein
Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene. Function LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II. Interactions LDL-receptor-related protein-associated protein has been shown to interact with LRP2. Mutations and diseases related to LRPAP1 Lipid metabolizing proteins may elevate susceptibility to dementia leading to differences in genetic makeup. PCR-restriction fragment length polymorphism technique is used for genotyping of LRPAP1 intron 5 insertion/deletion. The studies suggested that DD genotype and *D allele of LRPAP gene showed increased frequency for degenerative dementias on comparison with the control group and that LRPAP1-D allele remarkably increases the vulnerability to degenerative dementias. On genotyping of LRPAP1 polymorphism is observed because of 37 base pair insertion in intron 5. Also
https://en.wikipedia.org/wiki/David%20Luenberger
David Gilbert Luenberger (born September 16, 1937) is a mathematical scientist known for his research and his textbooks, which center on mathematical optimization. He is a professor in the department of Management Science and Engineering at Stanford University. Biography Luenberger was one of the original founders of the Department of Engineering-Economic Systems in 1967. He served as chairman of the department for eleven years. He worked as a professor at the University for 50 years, retiring as of September 2013. He has over 70 technical publications on systems and control, in optimization, in microeconomics, and in financial engineering. His Investment Science is widely prescribed and referenced by finance academics and practitioners. He received his B.S. in Electrical Engineering from the California Institute of Technology in 1959, and he received his Ph.D. in Electrical Engineering from Stanford University in 1963. In his dissertation Luenberger introduced new methods for construction of state observers. The celebrated Luenberger observer is named after him. Books References External links List of members of the National Academy of Engineering (Electronics) Stanford homepage investmentscience.com Biography of David Luenberger from the Institute for Operations Research and the Management Sciences Numerical analysts American operations researchers Financial economists General equilibrium theorists Microeconomists Theoretical computer scientists American computer s
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20New%20Jersey
This is a list of law enforcement agencies in the state of New Jersey. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 550 law enforcement agencies employing 33,704 sworn police officers, about 389 for each 100,000 residents. State agencies New Jersey Department of Corrections New Jersey Department of Environmental Protection Division of Fish and Wildlife Bureau of Law Enforcement (State Conservation Officers) Division of Parks and Forestry New Jersey Forest Fire Service New Jersey DEP Marine Law Enforcement Unit New Jersey Department of Human Services Police New Jersey Office of the Attorney General Department of Law and Public Safety Division of Alcoholic Beverage Control Division of Consumer Affairs Office of Consumer Protection Enforcement Bureau Office of Weights and Measures NJ Division of Criminal Justice Division of Gaming Enforcement New Jersey Department of the Treasury Division of Taxation Office of Criminal Investigations New Jersey Juvenile Justice Commission New Jersey Office of Homeland Security and Preparedness New Jersey Election Law Enforcement Commission New Jersey State Park Police New Jersey State Parole Board Division of Parole (State Parole Officers) New Jersey State Police New Jersey State Detective Agency New Jersey Transit Police Department County Prosecutor's Office Atlantic County Prosecutor's Office Bergen County Prosecutor's Office B
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20New%20Mexico
This is a list of law enforcement agencies in the state of New Mexico. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 146 law enforcement agencies employing 5,010 sworn police officers, about 252 for each 100,000 residents. This is almost exactly the national average of policemen to residents in the United States. State agencies New Mexico Department of Public Safety New Mexico State Police New Mexico Mounted Patrol New Mexico Attorney General's Office New Mexico Board of Pharmacy New Mexico Corrections Department New Mexico Department of Game and Fish New Mexico Energy, Minerals and Natural Resources Department New Mexico State Forestry Division Special Agents New Mexico State Parks Division Park Rangers New Mexico Livestock Inspector Board New Mexico Taxation and Revenue Department Office of the Inspector General Tax Fraud Investigations Division County agencies Bernalillo County Sheriff's Department Catron County Sheriff's Department Chaves County Sheriff’s Office Cibola County Sheriff's Office Colfax County Sheriff's Office Curry County Sheriff's Office De Baca County Sheriff's Office Doña Ana County Sheriff's Office Eddy County Sheriff's Office Grant County Sheriff's Department Guadalupe County Sheriff's Office Harding County Sheriff's Department Hidalgo County Sheriff's Department Lea County Sheriff's Department Lincoln County Sheriff's Office Los Alamos County Police
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20North%20Carolina
This is a list of law enforcement agencies in the state of North Carolina. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 504 law enforcement agencies employing 23,442 sworn police officers, about 254 for each 100,000 residents. As of June 2022, this is the latest data available, as the report has not been conducted since 2008. State agencies Black Mountain Neuro-Medical Treatment Center Police - Black Mountain, North Carolina (NC Department of Health & Human Services) Broughton Hospital Police - Morganton, North Carolina (NC Department of Health & Human Services) Cherry Hospital Police – Goldsboro, North Carolina (NC Department of Health & Human Services) Longleaf Neuro-Medical Treatment Center Police - Wilson, North Carolina (NC Department of Health & Human Services) North Carolina Alcohol Law Enforcement North Carolina Arboretum Campus Police - Asheville, North Carolina North Carolina Department of Agriculture State Fairgrounds Police - Raleigh, North Carolina North Carolina Department of Insurance Criminal Investigations Division North Carolina Division of Marine Fisheries Marine Patrol North Carolina Division of Motor Vehicles License and Theft Bureau North Carolina Division of Parks Law Enforcement Rangers North Carolina General Assembly Police North Carolina State Bureau of Investigation North Carolina State Capitol Police North Carolina State Highway Patrol North Carolina Di
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20North%20Dakota
This is a list of law enforcement agencies in the state of North Dakota. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 114 law enforcement agencies employing 1,324 sworn officers, about 206 for each 100,000 residents. State agencies North Dakota Bureau of Criminal Investigation North Dakota Department of Corrections and Rehabilitation North Dakota Game and Fish Department North Dakota Highway Patrol North Dakota State Fire Marshal North Dakota Parks and Recreation Department County agencies Adams County Sheriff's Office Barnes County Sheriff's Office Benson County Sheriff's Office Billings County Sheriff's Office Bottineau County Sheriff's Office Bowman County Sheriff's Office Burke County Sheriff's Office Burleigh County Sheriff's Office Cass County Sheriff's Office Cavalier County Sheriff's Office Dickey County Sheriff's Office Divide County Sheriff's Office Dunn County Sheriff's Office Eddy County Sheriff's Office Emmons County Sheriff's Office Foster County Sheriff's Office Golden Valley County Sheriff's Office Grand Forks County Sheriff's Office Grant County Sheriff's Office Griggs County Sheriff's Office Hettinger County Sheriff's Office Kidder County Sheriff's Office Lamoure County Sheriff's Office Logan County Sheriff's Office McHenry County Sheriff's Office McIntosh County Sheriff's Office McKenzie County Sheriff's Office McLean County Sheriff's Office Mercer County Sheriff's Office Morto
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Ohio
This is a list of law enforcement agencies in the state of Ohio. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 831 law enforcement agencies employing 25,992 sworn police officers, about 225 for each 100,000 residents. State agencies Ohio Attorney General Ohio Bureau of Criminal Investigation Ohio State Auditor Ohio Board of Pharmacy Ohio Casino Control Commission Ohio Department of Commerce Ohio State Fire Marshal Ohio Department of Developmental Disabilities Cambridge Developmental Center Columbus Developmental Center Gallipolis Developmental Center Mount Vernon Developmental Center Northwest Ohio Developmental Center Southwest Ohio Developmental Center Tiffin Developmental Center Warrensville Developmental Center Ohio Department of Mental Health and Addiction Services Appalachian Behavioral Healthcare Heartland Behavioral Healthcare Northcoast Behavioral Healthcare Northwest Ohio Psychiatric Hospital Summit Behavioral Healthcare Twin Valley Behavioral Healthcare Ohio Department of Natural Resources Division of Parks and Watercraft Division of Wildlife Office of Law Enforcement Ohio Department of Public Safety Ohio State Highway Patrol Investigative Unit Highway Patrol Police Ohio Department of Rehabilitation and Corrections Ohio Department of Taxation Ohio Department of Veterans Services Veterans Home Police Department Ohio House of Representatives Ohio Senate
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Oklahoma
This is a list of law enforcement agencies in the state of Oklahoma. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 483 law enforcement agencies employing 8,639 sworn police officers, about 237 for each 100,000 residents. State agencies Attorney General of Oklahoma Grand River Dam Authority Police Department Oklahoma Alcoholic Beverage Laws Enforcement Commission Oklahoma Bureau of Narcotics and Dangerous Drugs Control Oklahoma Office of the Chief Medical Examiner Oklahoma Council on Law Enforcement Education and Training Oklahoma Criminal Justice Resource Center Oklahoma Department of Corrections Oklahoma Department of Emergency Management Oklahoma Department of Environmental Quality Criminal Investigation Unit Oklahoma Department of Public Safety Oklahoma Highway Patrol Oklahoma Office of Homeland Security Oklahoma Department of Tourism and Recreation Oklahoma State Park Rangers Oklahoma Department of Wildlife Conservation Oklahoma District Attorneys Council Oklahoma Department of Insurance Anti-Fraud Unit Oklahoma Office of Juvenile Affairs Oklahoma Pardon and Parole Board Oklahoma State Board of Pharmacy Oklahoma State Bureau of Investigation Oklahoma State Fire Marshal Oklahoma Law Enforcement Retirement System Oklahoma Police Pension and Retirement System Oklahoma Department of Agriculture Investigative Services Unit Oklahoma Department of Human Services Office of Inspector General County sh
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Oregon
This is a list of law enforcement agencies in the U.S. state of Oregon. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 174 law enforcement agencies employing 6,695 sworn police officers, about 177 for each 100,000 residents. State agencies Oregon Board of Parole and Post-Prison Supervision Oregon Department of Corrections Oregon Department of Justice Oregon Department of Transportation Motor Carrier Enforcement Oregon Liquor and Cannabis Commission Oregon State Police Oregon State Fire Marshal Oregon Youth Authority County agencies Baker County Sheriff's Office Benton County Sheriff's Office Clackamas County Sheriff's Office Clatsop County Sheriff's Office Columbia County Sheriff's Office Coos County Sheriff's Office Crook County Sheriff's Office Curry County Sheriff's Office Deschutes County Sheriff's Office Douglas County Sheriff's Office Gilliam County Sheriff's Office Grant County Sheriff's Office Harney County Sheriff's Office Hood River County Sheriff's Office Jackson County Sheriff's Office Jefferson County Sheriff's Office Josephine County Sheriff's Office Klamath County Sheriff's Office Lake County Sheriff's Office Lane County Sheriff's Office Lincoln County Sheriff's Office Linn County Sheriff's Office Malheur County Sheriff's Office Marion County Sheriff's Office Morrow County Sheriff's Office Multnomah County Sheriff's Office Polk County Sheriff's O
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Rhode%20Island
According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 48 law enforcement agencies employing 2,828 sworn police officers, about 268 for each 100,000 residents. State agencies Rhode Island Department of Corrections Rhode Island Department of Environmental Management Division of Law Enforcement Rhode Island Department of Public Safety Rhode Island State Police Rhode Island Capitol Police Division of Sheriffs Office of the State Fire Marshal Rhode Island Office of the Attorney General Bureau of Criminal Identification and Investigation Municipal agencies Barrington Police Department Bristol Police Department Burrillive Police Department Central Falls Police Department Charlestown Police Department Coventry Police Department Cranston Police Department Cumberland Police Department East Greenwich Police Department East Providence Police Department Foster Police Department Glocester Police Department Hopkinton Police Department Jamestown Police Department Johnston Police Department Lincoln Police Department Little Compton Police Department Middletown Police Department Narragansett Police Department Newport Police Department New Shoreham Police Department North Kingstown Police Department North Providence Police Department North Smithfield Police Department Pawtucket Police Department Portsmouth Police Department Providence Police Department Richmond Police Department Scituate Police Department Smithfie
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20South%20Carolina
This is a list of law enforcement agencies in the state of South Carolina. According to the US Bureau of Justice Statistics' 2022 'Census of State and Local Law Enforcement Agencies,'' the state had 272 law enforcement agencies employing 11,674 sworn police officers, about 259 for each 100,000 residents. State agencies South Carolina Department of Corrections (SCDC) Office of Inspector General(OIG) South Carolina Department of Natural Resources, Law Enforcement Division (SCDNR) South Carolina Department of Public Safety (SCDPS) South Carolina Highway Patrol (SCHP) South Carolina State Transport Police Division (SCSTP) South Carolina Bureau of Protective Services (BPS) South Carolina Law Enforcement Division (SLED) South Carolina State Constable's Office South Carolina State Ports Authority Port Police South Carolina Department of Probation, Parole, and Pardon Services (SCDPPPS) South Carolina Department of Mental Health Public Safety (SCDMHPS) South Carolina State Forestry Commission Law Enforcement South Carolina Department of Juvenile Justice County agencies City and town agencies College agencies Allen University Police Department Benedict College Police Department Bob Jones University Police Department Clemson University Police Department Coastal Carolina University Department of Public Safety Denmark Technical College Department of Public Safety Erskine College Police Department Francis Marion University Police Department Furman University Police
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20South%20Dakota
This is a list of law enforcement agencies in the state of South Dakota. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 155 law enforcement agencies employing 1,636 sworn police officers, about 203 for each 100,000 residents. State agencies South Dakota Division of Criminal Investigation South Dakota Department of Corrections South Dakota Department of Public Safety South Dakota Department of Public Safety Safety & Enforcement South Dakota Highway Patrol South Dakota Office of Highway Safety South Dakota Department of Homeland Security South Dakota Game, Fish, & Parks Conservation Officers South Dakota Commission on Gaming South Dakota Motor Carrier The Huron Police Department is the South Dakota's State Fair Police Department. Federal Agencies within South Dakota Bureau of Alcohol, Tobacco, Firearms and Explosives Field Divisions Bureau of Alcohol, Tobacco, Firearms and Explosives St. Paul Field Division/South Dakota Field Offices Bureau of Indian Affairs Bureau of Indian Affairs Regional Offices Bureau of Indian Affairs Office of Justice Services Bureau of Indian Affairs Office of Justice Services Districts Bureau of Indian Affairs Office of Justice Services Drug Division Enforcement Drug Enforcement Administration Drug Enforcement Administration Field Offices Federal Bureau of Investigation National Park Service United States Marshal's Service County agencies Aurora
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Tennessee
This is a list of law enforcement agencies in the state of Tennessee. According to the United States Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 375 law enforcement agencies employing 15,976 sworn police officers, about 256 for each 100,000 residents. State agencies Tennessee Alcoholic Beverage Commission Tennessee Bureau of Investigation Tennessee Department of Correction Tennessee Department of Revenue Tennessee Department of Safety and Homeland Security Tennessee Highway Patrol Tennessee Wildlife Resources Agency Tennessee Governor's Task Force on Marijuana Eradication County agencies Anderson County Sheriff's Office Bedford County Sheriff's Office Benton County Sheriff's Office Bledsoe County Sheriff's Office Blount County Sheriff's Office Bradley County Sheriff's Office Campbell County Sheriff's Office Cannon County Sheriff's Office Carroll County Sheriff's Office Carter County Sheriff's Office Cheatham County Sheriff's Office Chester County Sheriff's Office Claiborne County Sheriff's Office Clay County Sheriff's Office Cocke County Sheriff's Office Coffee County Sheriff's Office Crockett County Sheriff's Office Cumberland County Sheriff's Office Davidson County Sheriff's Office Decatur County Sheriff's Office DeKalb County Sheriff's Office Dickson County Sheriff's Office Dyer County Sheriff's Office Fayette County Sheriff's Office Fentress County Sheriff's Office Franklin County Sheriff'
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Texas
This is a list of law enforcement agencies in the U.S. state of Texas. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 1,913 law enforcement agencies, the most of any state. These agencies employed 59,219 sworn police officers, about 244 for each 100,000 residents. Federal agencies There are over 150 federal law enforcement offices in Texas. including those for the Federal Bureau of Prisons, Bureau of Alcohol, Tobacco, Firearms and Explosives; Customs and Border Protection; Drug Enforcement Administration; Federal Bureau of Investigation; Immigration and Customs Enforcement; United States Secret Service; Naval Criminal Investigative Service, and U.S. Marshals. According to the Bureau of Justice Statistics, a federal law enforcement agency is "an organizational unit, or subunit, of the federal government with the principle (sic) functions of prevention, detection, and investigation of crime and the apprehension of alleged offenders." State agencies Texas Alcoholic Beverage Commission Texas Attorney General Texas Comptroller - Criminal Investigation Division (State Police) Texas Commission on Law Enforcement (regulatory agency) Texas Department of Criminal Justice Texas Department of Insurance State Fire Marshal's Office Fraud Unit Texas Department of Public Safety Texas Highway Patrol Texas Ranger Division Texas Parks and Wildlife Department Texas Racing Commission - State Police Texas Juvenile Ju
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Utah
This is a list of law enforcement agencies in the state of Utah. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 136 law enforcement agencies employing 4,782 sworn police officers, about 175 for each 100,000 residents. State agencies Utah Department of Corrections Utah Adult Probation & Parole Utah Department of Human Services Division of Juvenile Justice Services Utah Department of Natural Resources Utah Division of State Parks and Recreation Park Rangers Utah Division of Wildlife Resources Conservation Officers Utah Attorney General and Assistant Attorneys General Utah Department of Public Safety Liquor Enforcement Section Utah State Fire Marshal Utah Highway Patrol Utah State Bureau of Investigation Utah Department of Transportation - Motor Carrier Safety - Port of Entry Utah Division of Insurance Fraud Utah State Tax Commission - Motor Vehicle Enforcement Division (MVED) Utah State Hospital - Campus Police County agencies Beaver County Sheriff's Office Box Elder County Sheriff's Office Cache County Sheriff's Office Carbon County Sheriff's Office Daggett County Sheriff's Office Davis County Sheriff's Office Duchesne County Sheriff's Office Emery County Sheriff's Office Garfield County Sheriff's Office Grand County Sheriff's Office Iron County Sheriff's Office Juab County Sheriff's Office Kane County Sheriff's Office Millard County Sheriff's Office Morgan County S
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Vermont
This is a list of law enforcement agencies in the state of Vermont. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 69 law enforcement agencies employing 1,103 sworn police officers, about 178 for each 100,000 residents. State agencies Vermont Capitol Police Vermont Department of Public Safety Vermont State Police Vermont Fish and Wildlife Department Division of Warden Service Vermont Department of Corrections Vermont Department of Liquor and Lottery Division of Liquor Control Vermont Secretary of State Office of Professional Regulation Investigative Unit Vermont Department of Motor Vehicles Enforcement and Safety Division Office of the Vermont Attorney General County agencies Addison County Sheriff's Office Bennington County Sheriff's Department Caledonia County Sheriff's Office Chittenden County Sheriff's Department Essex County Sheriff's Office Franklin County Sheriff's Department Grand Isle County Sheriff's Office Lamoille County Sheriff's Department Orange County Sheriff's Department Orleans County Sheriff's Office Rutland County Sheriff's Office Washington County Sheriff's Office Windham County Sheriff's Department Windsor County Sheriff's Department Municipal agencies Barre Police Department (City of Barre) Barre Police Department (Town of Barre) Bellows Falls Police Department Bennington Police Department Berlin Police Department Bradford Police Depart
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Virginia
This is a list of law enforcement agencies in the state of Virginia. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 340 law enforcement agencies employing 22,848 sworn police officers, about 293 for each 100,000 residents. State agencies Virginia Alcoholic Beverage Control Authority Virginia Department of Agriculture and Consumer Services - Charitable Gaming Virginia Department of Corrections Virginia Department of Fire Programs - State Fire Marshal's Office Virginia Department of Forestry Virginia Department of Juvenile Justice Virginia Department of Motor Vehicles Law Enforcement Division Virginia Department of Wildlife Resources Conservation Police General Assembly - Virginia Division of Capitol Police Virginia Marine Resources Commission - Virginia Marine Police Virginia Office of State Inspector General Virginia Port Authority Police Virginia State Corporation Commission - Bailiffs Virginia State Lottery Security Division Virginia State Parks Police Virginia State Police Special District agencies Chesapeake Bay Bridge-Tunnel District and Commission Police Department County agencies Accomack County Sheriff's Office Albemarle County Police Department Albemarle County Sheriff's Office Allegheny County Sheriff's Office Amelia County Sheriff's Office Amherst County Sheriff's Office Appomattox County Sheriff's Office Arlington County Police Department Arlington County Sheriff's Office
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Washington%20%28state%29
This is a list of law enforcement agencies in the US state of Washington. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 260 law enforcement agencies employing 11,411 sworn police officers, about 174 for each 100,000 residents. The state has the lowest ratio of police officers to residents of any state, compared to a national average of 251 per 100,000 residents. State agencies Washington State Attorney General's Office Washington State Department of Corrections Washington State Department of Fish and Wildlife Washington State Department of Labor and Industries Washington State Department of Natural Resources Washington State Gambling Commission Washington State Liquor and Cannabis Board Washington State Parks Washington State Patrol County agencies Adams County Sheriff's Office Asotin County Sheriff's Office Benton County Sheriff's Office Chelan County Sheriff's Office Clallam County Sheriff's Office Clark County Sheriff's Office Columbia County Sheriff's Office Cowlitz County Sheriff's Office Douglas County Sheriff's Office Ferry County Sheriff's Office Franklin County Sheriff's Office Garfield County Sheriff's Office Grant County Sheriff's Office Grays Harbor County Sheriff's Office Island County Sheriff's Office Jefferson County Sheriff's Office King County Sheriff's Office Kitsap County Sheriff's Office Kittitas County Sheriff's Office Klickitat County Sheriff's Office Le
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20West%20Virginia
This is a list of law enforcement agencies in the state of West Virginia. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 233 law enforcement agencies employing 3,382 sworn police officers, about 186 for each 100,000 residents. State agencies Hatfield-McCoy Recreation Area Park Rangers West Virginia Alcohol Beverage Control Administration West Virginia Division of Forestry Special Operations and Enforcement Division West Virginia Division of Natural Resources Law Enforcement Section (Natural Resources Police) West Virginia Division of Protective Services West Virginia Public Service Commission Motor Carrier Enforcement West Virginia State Fire Marshal's Office West Virginia State Police West Virginia Military Authority - Camp Dawson Security State Correctional agencies West Virginia Division of Corrections and Rehabilitation West Virginia Division of Juvenile Services (defunct) West Virginia Regional Jail Authority (defunct) County agencies Barbour County Sheriff's Office Berkeley County Sheriff's Office Boone County Sheriff's Office Braxton County Sheriff's Office Brooke County Sheriff's Office Cabell County Sheriff's Office Calhoun County Sheriff's Office Clay County Sheriff's Office Doddridge County Sheriff's Office Fayette County Sheriff's Office Gilmer County Sheriff's Office Grant County Sheriff's Office Greenbrier County Sheriff's Office Hampshire County Sheri
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Wisconsin
This is a list of law enforcement agencies in the state of Wisconsin. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 529 law enforcement agencies employing 13,730 sworn police officers, about 186 for each 100,000 residents. State agencies Wisconsin Capitol Police Wisconsin Department of Corrections Wisconsin Department of Justice Wisconsin Department of Natural Resources Division of Forestry Foresters, Forester-Rangers Division of Enforcement and Science; Bureau of Law Enforcement Conservation Wardens, Deputy Conservation Wardens Wisconsin Department of Transportation Wisconsin State Patrol Troopers, Inspectors Wisconsin State Fair Park Police Department County agencies Adams County Sheriff's Office Ashland County Sheriff's Office Barron County Sheriff's Office Bayfield County Sheriff's Office Brown County Sheriff's Office Buffalo County Sheriff's Office Burnett County Sheriff's Office Calumet County Sheriff's Office Chippewa County Sheriff's Office Clark County Sheriff's Office Columbia County Sheriff's Office Crawford County Sheriff's Office Dane County Sheriff's Office Dodge County Sheriff's Office Door County Sheriff's Office Douglas County Sheriff's Office Dunn County Sheriff's Office Eau Claire County Sheriff's Office Florence County Sheriff's Office Fond du Lac County Sheriff's Office Forest County Sheriff's Office Grant County Sheriff's Office Green Coun
https://en.wikipedia.org/wiki/Riemann%E2%80%93Hilbert%20problem
In mathematics, Riemann–Hilbert problems, named after Bernhard Riemann and David Hilbert, are a class of problems that arise in the study of differential equations in the complex plane. Several existence theorems for Riemann–Hilbert problems have been produced by Mark Krein, Israel Gohberg and others (see the book by Clancey and Gohberg (1981)). The Riemann problem Suppose that is a closed simple contour in the complex plane dividing the plane into two parts denoted by (the inside) and (the outside), determined by the index of the contour with respect to a point. The classical problem, considered in Riemann's PhD dissertation (see ), was that of finding a function analytic inside such that the boundary values of M+ along satisfy the equation for all , where a, b, and c are given real-valued functions . By the Riemann mapping theorem, it suffices to consider the case when is the unit circle . In this case, one may seek M+(z) along with its Schwarz reflection: On the unit circle Σ, one has , and so Hence the problem reduces to finding a pair of functions M+(z) and M−(z) analytic, respectively, on the inside and the outside of the unit disc, so that on the unit circle and, moreover, so that the condition at infinity holds: The Hilbert problem Hilbert's generalization was to consider the problem of attempting to find M+ and M− analytic, respectively, on the inside and outside of the curve Σ, such that on one has where α, β, and c are arbitrary given complex-valued
https://en.wikipedia.org/wiki/List%20of%20law%20enforcement%20agencies%20in%20Wyoming
This is a list of law enforcement agencies in the state of Wyoming. According to the US Bureau of Justice Statistics' 2008 Census of State and Local Law Enforcement Agencies, the state had 90 law enforcement agencies employing 1,691 sworn police officers, about 317 for each 100,000 residents. State agencies Wyoming Department of Transportation#Child agency 511 Info Wyoming DOT 511 Info Road Wyoming DOT Aeronautics Wyoming Highway Patrol WyDOT Tax Fuel Wyoming Department of Corrections Wyoming State Attorney General's Office Division of Criminal Investigation Wyoming Game and Fish Department Game Wardens Wyoming Division of State Parks and Historic Sites Park Rangers Wyoming Department of Fire Prevention and Electrical Safety (State Fire Marshal) Fire Investigation Wyoming Livestock Board Law Enforcement Wyoming Gaming Commission (Employs two sworn investigators) Wyoming State Board of Outfitters and Professional Guides (Employs one sworn investigator) Wyoming Supreme Court (Employs one sworn bailiff) County agencies Albany County Sheriff's Office Big Horn County Sheriff's Office Campbell County Sheriff's Office Carbon County Sheriff's Office Converse County Sheriff's Office Crook County Sheriff's Office Fremont County Sheriff's Office Goshen County Sheriff's Office Hot Springs County Sheriff's Office Johnson County Sheriff's Office Laramie County Sheriff's Office Lincoln County Sheriff's Office Natrona County Sheriff's Office Niobrara Co
https://en.wikipedia.org/wiki/Metopon
Metopon (5-methylhydromorphone, CAS number 124-92-5) is an opioid analogue that is a methylated derivative of hydromorphone which was invented in 1929 as an analgesic. Metopon is sometimes used in medicine. Although longer acting than hydromorphone, metopon is less potent and its oral bioavailability is fairly low. Generally, metopon has few advantages to distinguish it from other, more commonly used opioid analgesics, although it does have a slightly lower tendency to produce nausea and respiratory depression compared to morphine. In Canada, as of 1948, the hydrochloride of metopon (free base conversion ratio 0.891, molecular weight 335.8) was available only for oral administration for malignant pain and for maintenance of those habituated to morphine; the only dosage form available was singly scored 8 mg tablets. It was manufactured by Parke, Davis, & Co., and was only for sale to doctors and hospitals. Parke, Davis & Co. did not sell metopon to pharmacies. It is unknown whether metopon tablets are still manufactured and sold in Canada. Metopon tablets, ampoules, and suppositories are available in Switzerland, Austria, Germany, and other countries in Continental Europe and the drug is used in Patient Controlled Analgesia pumps for severe chronic pain in particular. Metopon is listed under Schedule II of the US Controlled Substances Act 1970, meaning it has an accepted medical use, but at this time it is not produced commercially and is seen only in laboratory researc
https://en.wikipedia.org/wiki/Gary%20O%27Reilly
Gary Mills O'Reilly (born 21 March 1961) is an English former professional footballer who played in the Football League for Tottenham Hotspur, Brighton & Hove Albion, Crystal Palace and Birmingham City as a central defender. Life and career O'Reilly was born in Isleworth, now part of Greater London. He played for Grays Athletic before turning professional with Tottenham Hotspur in 1979, and made his debut the following year. After 45 League games for the club, he joined Brighton & Hove Albion for a £45,000 fee. He stayed with Brighton for two-and-a-half seasons before moving on to Crystal Palace. He scored in the 1989–90 FA Cup semi-final as Palace beat Liverpool 4–3 after extra time, and then scored the opening goal in the final, against Manchester United. The match ended in a 3–3 draw, and Palace lost replay 1–0 five days later. After a brief spell on loan at Birmingham City, O'Reilly rejoined Brighton & Hove Albion in January 1991. Brighton finished that season sixth in the Second Division and reached the playoff final, where they were beaten by Notts County. Any hopes of another promotion challenge the following season – and of a place in the new FA Premier League – were quickly forgotten as Brighton found themselves fighting a battle against relegation which was eventually lost. O'Reilly then retired from playing. Following his retirement from football, he made a career in sports broadcasting. He has appeared on BBC Five Live's Fighting Talk, as a pundit on pan-Afric
https://en.wikipedia.org/wiki/List%20of%20Middlesbrough%20F.C.%20records%20and%20statistics
This article contains the honours, records and statistics of Middlesbrough Football Club. This article lists all of the major honours won by Middlesbrough since their foundation. This list also lists the major playing honours including top goalscorer and most appearances. The Club records including record transfer fees are shown below as are international player honours. Middlesbrough are an English professional association football club based in Middlesbrough, in the Tees Valley, who currently play in the EFL Championship. The club was founded in 1876 and have played at their current home ground, the Riverside Stadium, since 1995. Middlesbrough were founding members of the Premier League in 1992. They have won one major trophy in their history: the 2004 Football League Cup. Honours Domestic League Football League Second Division / Football League Division One Champions 1926–27, 1928–29, 1973–74, 1994–95; runners up 1901–02, 1991–92, 1997–98, 2015–16 Football League Third Division Runners up 1966–67, 1986–87 Northern League Champions 1893–94, 1894–95, 1896–97; runners up 1890–91, 1891–92, 1897–98 Cup League Cup Winners 2003–04; runners up 1996–97, 1997–98 FA Cup Runners up 1996–97 FA Amateur Cup Winners 1894–95, 1897–98 Zenith Data Systems Cup Runners up 1990 International UEFA Cup Runners up 2005–06 Anglo-Scottish Cup Winners 1975 Kirin Cup Winners 1980 Player records Appearances Youngest first-team player – 16 years and 72 days Nathan Wood (vs Notts County 14 Aug
https://en.wikipedia.org/wiki/Florian%20Marange
Florian Marange (born 3 March 1986) is a French former professional footballer, who played as a left-back. His former clubs include Girondins de Bordeaux and Crystal Palace. Career Marange began his career in 2002 with Girondins de Bordeaux and was promoted to the first team in 2004. He gave on 20 November 2005 his first games against Paris Saint-Germain. He was loaned out to Le Havre AC from FC Girondins de Bordeaux on 8 January 2009 and returned on 1 July 2009. On 16 August 2013, Marange signed a one-year deal with English side Crystal Palace, on a Bosman transfer. He made his debut on 27 August, in a 2–1 defeat against Bristol City in the second round of the League Cup. However, he was left out of Palace's 25-man Premier League squad and was described as 'slow' by manager Ian Holloway. He made only a few further appearances in friendly and reserve games for Palace before his contract was paid up in October. In January 2014, Marange signed for Ligue 1 side FC Sochaux-Montbéliard. Six months later, he signed a two-year contract with SC Bastia. Honours Bordeaux Coupe de la Ligue: 2006–07 Coupe de France: 2012–13 References External links 1986 births Living people People from Talence Footballers from Gironde French men's footballers French expatriate men's footballers France men's youth international footballers France men's under-21 international footballers Men's association football defenders FC Girondins de Bordeaux players Le Havre AC players AS Nancy Lorrain
https://en.wikipedia.org/wiki/Bing%20metrization%20theorem
In topology, the Bing metrization theorem, named after R. H. Bing, characterizes when a topological space is metrizable. Formal statement The theorem states that a topological space is metrizable if and only if it is regular and T0 and has a σ-discrete basis. A family of sets is called σ-discrete when it is a union of countably many discrete collections, where a family of subsets of a space is called discrete, when every point of has a neighborhood that intersects at most one member of History The theorem was proven by Bing in 1951 and was an independent discovery with the Nagata–Smirnov metrization theorem that was proved independently by both Nagata (1950) and Smirnov (1951). Both theorems are often merged in the Bing-Nagata-Smirnov metrization theorem. It is a common tool to prove other metrization theorems, e.g. the Moore metrization theorem – a collectionwise normal, Moore space is metrizable – is a direct consequence. Comparison with other metrization theorems Unlike the Urysohn's metrization theorem which provides a sufficient condition for metrization, this theorem provides both a necessary and sufficient condition for a topological space to be metrizable. See also References "General Topology", Ryszard Engelking, Heldermann Verlag Berlin, 1989. Theorems in topology de:Satz von Bing-Nagata-Smirnow
https://en.wikipedia.org/wiki/MAD1L1
Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene. MAD1L1 is also known as Human Accelerated Region 3. It may have played a key role in the evolution of humans from apes. Function MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Some studies indicate associations of MAD1L1 with psychiatric disorders, including schizophrenia, bipolar disorder, and depression. Three transcript variants encoding the same protein have been found for this gene. Interactions MAD1L1 has been shown to interact with: HDAC1, Histone deacetylase 2, and MAD2L1, See also MAD1 MAD2 Hyperphosphorylation References
https://en.wikipedia.org/wiki/Uridine%20diphosphate%20glucose
Uridine diphosphate glucose (uracil-diphosphate glucose, UDP-glucose) is a nucleotide sugar. It is involved in glycosyltransferase reactions in metabolism. Functions UDP-glucose is used in nucleotide sugar metabolism as an activated form of glucose, a substrate for enzymes called glucosyltransferases. UDP-glucose is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid. UDP-glucose can also be used as a precursor of sucrose, lipopolysaccharides and glycosphingolipids. Components UDP-glucose consists of the pyrophosphate group, ribose, glucose, and uracil. See also DNA Nucleoside Nucleotide Oligonucleotide RNA TDP-glucose Uracil Uridine diphosphate References Nucleotides Coenzymes
https://en.wikipedia.org/wiki/PFAS%20%28disambiguation%29
PFAS or PFASs are per- and polyfluoroalkyl substances, a large class of synthetic chemicals. PFAS or PFASS may also refer to: Phosphoribosylformylglycinamidine synthase, an enzyme Personal fall arrest system, in workplace safety Philadelphia Female Anti-Slavery Society
https://en.wikipedia.org/wiki/The%20Ascension%20%28Glenn%20Branca%20album%29
The Ascension is the debut studio album by American no wave musician Glenn Branca, released in November 1981 by 99 Records. The album experiments with resonances generated by alternate tunings for multiple electric guitars. It sold 10,000 copies and received acclaim from music critics. Background Branca wanted to explore the resonances generated when guitar strings tuned to the same note were played at high volumes. He assembled the Ascension Band with four electric guitarists, one bassist, and one drummer. The group included guitarist Lee Ranaldo, who later joined alternative rock band Sonic Youth. The group's bass player knew the owner and engineers at The Power Station, so they were able to use it at little cost. They recorded five pieces in between tours for Branca's debut EP Lesson No. 1. "The Spectacular Commodity" was written before the songs on Lesson No. 1, originating as a dance piece for Branca's band the Static. The album's title was chosen as a continuation of works by Olivier Messiaen and John Coltrane. Its iconic black-and-white cover artwork is by painter Robert Longo. It comes from Longo's "Men in the Cities" series, which depicts well-dressed young professionals in contorted poses. The cover shows Branca in a suit, dragging the dead body of another man. Branca has stated that he wanted to show two men having sex; instead, he asked Longo to "make an implication of this." Songs Opening track "Lesson No. 2" starts with a bass riff. It builds with tom-tom dr
https://en.wikipedia.org/wiki/BJPS
BJPS may refer to: Brebeuf Jesuit Preparatory School British Journal for the Philosophy of Science British Journal of Political Science Brazilian Journal of Probability and Statistics
https://en.wikipedia.org/wiki/Thymol%20blue
Thymol blue (thymolsulfonephthalein) is a brownish-green or reddish-brown crystalline powder that is used as a pH indicator. It is insoluble in water but soluble in alcohol and dilute alkali solutions. It transitions from red to yellow at pH 1.2–2.8 and from yellow to blue at pH 8.0–9.6. It is usually a component of Universal indicator. At wavelength (378 - 382) nm, extinction coefficient > 8000 and at wavelength (298 - 302) nm , the extinction coefficient > 12000. Structures Thymol blue has different structures at different pH. thymol blue. Safety It may cause irritation. Its toxicological properties have not been fully investigated. Harmful if swallowed, Acute Toxicity. Only Hazardous when percent values are above 10%. Bibliography Merck. "Thymol Blue." The Merck Index. 14th ed. 2006. Accessed via web on 2007-02-25. References External links PubChem entry PH indicators Triarylmethane dyes Benzenesulfonates Phenol dyes Isopropyl compounds
https://en.wikipedia.org/wiki/Myomesin
Myomesin is a protein family found in the M-line of the sarcomere structure. Myomesin has various forms throughout the body in striated muscles with specialized functions. This includes both slow and fast muscle fibers. Myomesin are made of 13 domains including a unique N-terminal followed by two immunoglobulin-like (Ig) domains, five fibronectin type III (Fn) domains, five more Ig domains. These domains all promote binding which indicates that myomesin is regulated through binding. Functions Sarcomere structure Myomesin plays an important role in the structure of sarcomeres. They are found in the M-band region of the sarcomere, between the thick filaments (myosin). Its main purpose in this setting is to provide structural integrity by linking the antiparallel myosin fibers and titin filaments which are connected to the Z-discs. These myosin filaments form a hexagonal lattice with titin and myomesin. This shape allows the M-band to withstand large conformational changes during muscle contraction and return to their original shape upon relaxation. Since the Z-disc region of the sarcomere is very stiff and unable to bend for contraction, the elastic activity of myomesin in the M-band is what makes muscle contraction possible as it acts as a molecular spring. Sarcomere assembly In addition to sarcomere activity, it has been shown that myomesin also plays a role in the assembly of the sarcomere. In order for myomesin to be implemented into the sarcomere, myosin and titin mu
https://en.wikipedia.org/wiki/Sialoadhesin
Sialoadhesin is a cell adhesion molecule found on the surface of macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients with rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). Sialoadhesin predominantly binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces. Sialoadhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the hematopoietic stem cell niche in the bone marrow. CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the nich
https://en.wikipedia.org/wiki/Acetolactate%20synthase
The acetolactate synthase (ALS) enzyme (also known as acetohydroxy acid or acetohydroxyacid synthase, abbr. AHAS) is a protein found in plants and micro-organisms. ALS catalyzes the first step in the synthesis of the branched-chain amino acids (valine, leucine, and isoleucine). A human protein of yet unknown function, sharing some sequence similarity with bacterial ALS, is encoded by the ILVBL (ilvB-like) gene. Structure Gene Human ILVBL gene has 17 exons resides on chromosome 19 at q13.1. Protein The catalytic peptide of ALS in Arabidopsis thaliana (mouse-eared cress) is a chloroplastic protein consisting of 670 residues, the last 615 of which form the active form. Three main domains are found, with two thiamine pyrophosphate sandwiching a DHS-like NAD/FAD-binding domain. In SCOP assignment, these subunits are named d1yhya1, d1yhya2, and d1yhya3 from the N-terminal to the C-termianl. The structure of acetolactate synthase that was used for the picture on this page was determined using X-ray diffraction at 2.70 angstroms. X-ray diffraction uses X-rays at specified wavelengths to produce patterns, as the X–ray is scattered in certain ways that give an idea to the structure of the molecule being analyzed. There are five specific ligands that interact with this protein. The five are listed below. The FAD bound is not catalytic. Function Acetolactate synthase is catalytic enzyme involved in the biosynthesis of various amino acids. This enzyme has the Enzyme Commission
https://en.wikipedia.org/wiki/Cytochrome%20b5%20reductase
Cytochrome-b5 reductase is a NADH-dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form. It contains FAD and catalyzes the reaction: In its b5-reducing capacity, this enzyme is involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, and drug metabolism. This enzyme can also reduce methemoglobin to normal hemoglobin, gaining it the inaccurate synonym methemoglobin reductase. Isoforms expressed in erythrocytes (CYB5R1, CYB5R3) perform this function in vivo. Ferricyanide is another substrate in vitro. The following four human genes encode cytochrome-b5 reductases: CYB5R1 CYB5R2 CYB5R3 CYB5R4 CYB5RL See also Cytochrome b5 Diaphorase Methemoglobinemia Reductase Leghemoglobin reductase References External links EC 1.6.2
https://en.wikipedia.org/wiki/Dihydrolipoamide%20dehydrogenase
Dihydrolipoamide dehydrogenase (DLD), also known as dihydrolipoyl dehydrogenase, mitochondrial, is an enzyme that in humans is encoded by the DLD gene. DLD is a flavoprotein enzyme that oxidizes dihydrolipoamide to lipoamide. Dihydrolipoamide dehydrogenase (DLD) is a mitochondrial enzyme that plays a vital role in energy metabolism in eukaryotes. This enzyme is required for the complete reaction of at least five different multi-enzyme complexes. Additionally, DLD is a flavoenzyme oxidoreductase that contains a reactive disulfide bridge and a FAD cofactor that are directly involved in catalysis. The enzyme associates into tightly bound homodimers required for its enzymatic activity. Structure The protein encoded by the DLD gene comes together with another protein to form a dimer in the central metabolic pathway. Several amino acids within the catalytic pocket have been identified as important to DLD function, including R281 and N473. Although the overall fold of the human enzyme is similar to that of yeast, the human structure is different in that it has two loops that extend from the general protein structure and into the FAD binding sites when bound the NAD+ molecule, required for catalysis, is not close to the FAD moiety. However, when NADH is bound instead, it is stacked directly op top of the FAD central structure. The current hE3 structures show directly that the disease-causing mutations occur at three locations in the human enzyme: the dimer interface, the active
https://en.wikipedia.org/wiki/Azercell
Azercell is an Azerbaijani telecommunications company based in Baku. It is the largest mobile network operator in Azerbaijan. Company background Azercell Telecom LLC was established on 19 January 1996. Azercell Telecom started its activities on 15 December 1996 offering subscribers mobile telecommunications services based on postpaid system. MTS The prepaid system was launched with tariff package — SimSim, in 1998. On 5 March 2018, Azerbaijan International Telecom (AzInTelecom) and the company Fintur Holdings B.V. signed an agreement to sell 51.3 percent of the shares of Azertel Telekomunikasyon Yatırım Dış Ticaret A.Ş. (Azertel). Azertel is the sole founder of Azercell Telecom Limited Liability Company. Services 4G Azercell announced on 24 May 2012, the launch of services based on the 4G platform. Azercell's 4G network covers all of Baku city and nearby towns. The networks operates on 1800 MHz frequency. MTS The second region where the 4G network got deployed, is the Nakhchivan Autonomous Republic. Market share and coverage 51% of Azerbaijan’s mobile market belongs to Azercell; while its geographical coverage constitutes 94,15% and population coverage is 98.70%. Subscribers Investments Since Azercell began operations in December 1996, the company has invested more than US$2 billion in Azerbaijan. Taxes According to Azerbaijan's Ministry of Taxes, Azercell Telecom LLC is the second largest taxpayer operating outside of the country's oil sector. During its first
https://en.wikipedia.org/wiki/Zastava%20M93%20Black%20Arrow
The M93 Black Arrow (/M93 Crna strela) is a 12.7×108mm anti-materiel rifle developed and manufactured by Zastava Arms. Overview The rifle was designed in 1993 and entered production in 1998. The primary purpose of this rifle is long-range engagement and due to that, it is provided with an optical sight, which is included in the rifle set (8x magnification with the division up to 1,800 m) and a backup iron sight. Its mount can accept the sights of other manufacturers as well. Design and features The Zastava M93 Black Arrow rifle is available in both 12.7×108mm and .50 BMG. It is a bolt-action, air-cooled, magazine-fed firearm with a fixed stock. The weapon is fed through a 5- or 10-round detachable, spring-loaded box magazine. The shoulder stock has a telescoping design, sitting aft of the ergonomic pistol grip unit. The bolt-action handle rests over the right side of the gun body. A carrying handle is affixed to the forend and the barrel is capped by a multi-baffled brake to assist in handling the massive recoil action. A folding bipod is also attached. Its overall design is a scale-up of the Mauser 98 system, similarly to the Mauser 1918 T-Gewehr, with some influence from the French FR-F1 However the FR-F1 was built on basis of MAS-36 that was also influenced by Gewehr 98 (Mauser 98). Therefore the M93 and FR-F1 have some roots in Mauser 98. The M93 has a trigger block safety design similar to Russian SVT 40 rifle Users : Used by Army Marksman : Peshmerga YPG See
https://en.wikipedia.org/wiki/Timeless%20%28gene%29
Timeless (tim) is a gene in multiple species but is most notable for its role in Drosophila for encoding TIM, an essential protein that regulates circadian rhythm. Timeless mRNA and protein oscillate rhythmically with time as part of a transcription-translation negative feedback loop involving the period (per) gene and its protein. Discovery In 1994, timeless was discovered through forward genetic screening performed by Jeffery L. Price while working in the lab of Michael W. Young. This gene was found when they noticed an arrhythmic tim01 mutant via a P element screen. The tim01 mutation caused arrhythmic behavior, defined by the lack of ability to establish proper circadian rhythms. In 1995, the timeless gene was cloned by Amita Sehgal and partners in the lab of Michael W. Young. Unlike the Drosophila timeless gene, homologs have been discovered in other species that are non-essential for circadian rhythm. The discovery of timeless followed the discovery of the period mutants in 1971 through forward genetic screening, the cloning of per in 1984, and an experiment determining that per is circadian in 1990. This occurred during a period of rapid expansion in the field of chronobiology in the 1990s. Structure The length of the coding region of the Drosophila timeless gene is 4029 base pairs, from which a 1398 amino acid protein is transcribed. The gene starts at a consensus cap site upstream of a methionine codon. It contains 11 exons and 10 introns. In various Drosoph
https://en.wikipedia.org/wiki/AFCB
AFCB may refer to: AFC Bournemouth, an English football club American Fuel Cell Bus, a zero-emission transit bus based on the ENC Axess with a hydrogen fuel cell and electric traction motor Armed Forces Chaplains Board, a U.S. Department of Defense organization of military Chiefs and Deputy Chiefs of Chaplains
https://en.wikipedia.org/wiki/Cholesteryl%20oleyl%20carbonate
Cholesteryl oleyl carbonate (COC) is an organic chemical, a carbonate ester of cholesterol and oleyl alcohol with carbonic acid. It is a liquid crystal material forming cholesteric liquid crystals with helical structure. It is a transparent liquid, or a soft crystalline material with melting point around 20 °C. It can be used with cholesteryl nonanoate and cholesteryl benzoate in some thermochromic liquid crystals. It is used in some hair colors, make-ups, and some other cosmetic preparations. It can be also used as a component of the liquid crystals used for liquid crystal displays. References Cholestanes Liquid crystals Carbonate esters
https://en.wikipedia.org/wiki/Cholesteryl%20benzoate
Cholesteryl benzoate, also called 5-cholesten-3-yl benzoate, is an organic chemical, an ester of cholesterol and benzoic acid. It is a liquid crystal material forming cholesteric liquid crystals with helical structure. It can be used with cholesteryl nonanoate and cholesteryl oleyl carbonate in some thermochromic liquid crystals. It is used in some hair colors, make-ups, and some other cosmetic preparations. It can be also used as a component of the liquid crystals used for liquid crystal displays. Cholesteryl benzoate was the first material in which liquid crystal properties were discovered. In the late 1880s Friedrich Reinitzer, an Austrian botanist, while studying the chemicals in plants, heated cholesteryl benzoate. At 145 °C the material melted, yielding a cloudy fluid, which changed to the originally expected clear liquid at 178.5 °C. In 1888, the German physicist Otto Lehmann concluded the cloudy fluid presents a new phase of matter, and coined the term liquid crystal. References Cholestanes Liquid crystals Benzoate esters
https://en.wikipedia.org/wiki/Cholesteryl%20chloride
Cholesteryl chloride, also called 3-chlorocholest-5-ene or 3β-chlorocholest-5-ene, is an organic chemical, an organochloride derivate cholesterol. It is a liquid crystal material forming clockwise cholesteric liquid crystals. It is a transparent liquid, or a soft crystalline material with melting point around 94-96 °C. It can be used with cholesteryl nonanoate, cholesteryl benzoate, and/or cholesteryl oleyl carbonate in some thermochromic liquid crystals. It is used in some hair colors, make-ups, and some other cosmetic preparations. It can be also used as a component of the liquid crystals used for liquid crystal displays. References Organochlorides Cholestanes Liquid crystals
https://en.wikipedia.org/wiki/Totivirus
Totivirus is a genus of double-stranded RNA viruses in the family Totiviridae. Fungi serve as natural hosts. The name of the group derives from Latin toti which means undivided or whole. There are seven species in this genus. Structure Viruses in the genus Totivirus are non-enveloped, with icosahedral symmetry, and T=2 architecture. The diameter is around 40 nm. Genome Totiviruses have a genome of 4700–6700 nucleotides in length and only a single copy of the genome is present in the particle. The nucleic acid content of a totivirus capsid is usually of one segment but can also contain three or four segments of linear double stranded RNA. The genome contains two large overlapping open reading frames (ORFs). These open reading frames (ORFs) code for a capsid protein (CP) and an RNA-dependent RNA polymerase (RdRp). The 5' end of the positive strand of the dsRNA genome has no cap and is very structured. Totiviruses contain a long 5' untranslated region (5' UTR) which functions as an internal ribosome entry site (IRES). Totiviruses can have satellite RNAs encoding a toxin. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by virus remains intracellular. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. Translation takes place by -1 ribosomal frameshifting. The virus exits the host cell by cell-to-cell movement. Fungi Saccharomyces cerevisiae and smut ser
https://en.wikipedia.org/wiki/Hans%20K.%20Ziegler
Hans K. Ziegler (March 1, 1911, Munich, Germany – December 11, 1999 Colts Neck Township, New Jersey, United States) was a pioneer in the field of communication satellites and the use of photovoltaic solar cells as a power source for satellites. Life Hans Ziegler was born in Munich, Germany. There, he studied at the Technische Hochschule, which is today the Technische Universität München (TUM), and began his career as Wissenschaftlicher Assistant (Scientific Assistant). Following that, he was a researcher in German industry for ten years. During the Second World War, he worked for the company Rosental Selb in Bavaria on high tension porcelain. In 1947, he came to the US with Wernher von Braun under Operation Paperclip, by means of which the USA gained Nazi engineers and scientists. He went to the US Army Signal Corps' Laboratories in Fort Monmouth, New Jersey, and became a US citizen in 1954. Ziegler's work in the US was very influential in the development of military electronics, especially in the electronics for the early phases of the US space program. During the thirty years he worked as an engineer in the field of electronics and electrical engineering in the research and development department of the U.S. Army in Fort Monmouth, N.J. (from 1947 to 1976), he held the top position of Chief Scientist for 12 years. In Fort Monmouth, he worked as a Scientific Consultant, Assistant Director of Research, Director of the Astro-Electronics Division and Chief Scientist (1959). A
https://en.wikipedia.org/wiki/Cunningham%20correction%20factor
In fluid dynamics, the Cunningham correction factor, or Cunningham slip correction factor (denoted ), is used to account for non-continuum effects when calculating the drag on small particles. The derivation of Stokes' law, which is used to calculate the drag force on small particles, assumes a no-slip condition which is no longer correct at high Knudsen numbers. The Cunningham slip correction factor allows predicting the drag force on a particle moving a fluid with Knudsen number between the continuum regime and free molecular flow. The drag coefficient calculated with standard correlations is divided by the Cunningham correction factor, , given below. Ebenezer Cunningham derived the correction factor in 1910 and with Robert Andrews Millikan, verified the correction in the same year. where is the correction factor is the mean free path is the particle diameter are experimentally determined coefficients. For air (Davies, 1945): A1 = 1.257 A2 = 0.400 A3 = 0.55 The Cunningham correction factor becomes significant when particles become smaller than 15 micrometers, for air at ambient conditions. For sub-micrometer particles, Brownian motion must be taken into account. References Fluid dynamics Dimensionless numbers Aerosols
https://en.wikipedia.org/wiki/Kushiro-shitsugen%20National%20Park
is a national park located in the east of the island of Hokkaido, Japan. It was designated as a national park on 31 July 1987. The park is known for its wetlands ecosystems. Kushiro-shitsugen (Kushiro Wetlands or Kushiro Swamp, Marshland) covers an area of on the Kushiro Plain (Kushiro-heiya) and contains the largest tracts of reedbeds in Japan. The Kushiro River (), which originates in Lake Kussharo, meanders through much of the park. During the Ramsar Convention of 1980, in which Japan participated, the park was first registered as a peatland with raised bogs. In 1967, the wetlands (shitsugen) themselves had been designated as a national natural monument. For that reason, access is strictly limited and the landscape, most typical of Hokkaido, has been preserved. Wildlife The vegetation of the park consists of reeds, sedges, peat moss wetlands, black alder thickets. The rivers which bend freely back and forth, groups of lakes and marshes, and other wet ecosystems comprise a varied environment. Kushiro-shitsugen is home to over 600 species of plants. The park is a valuable haven for wild species such as the red-crowned crane (Grus japonensis), huchen (Hucho perryi), Siberian salamander (Salamandrella keyserlingii) and dragonfly (Leucorrhinia intermedia ijimai). Geography Related cities, towns, and villages Kushiro Subprefecture Kushiro, Hokkaidō Kushiro, Hokkaidō (town) Shibecha, Hokkaidō Tsurui, Hokkaidō See also List of national parks of Japan References External l
https://en.wikipedia.org/wiki/Thinset
Thinset (also called thinset mortar, thinset cement, dryset mortar, or drybond mortar) is an adhesive mortar made of cement, fine sand and a water-retaining agent such as an alkyl derivative of cellulose. It is usually used to attach tile or stone to surfaces such as cement or concrete. It is particularly popular among mosaicists for outdoor applications Thinset is generally available in two types: unmodified and modified (polymer-modified). Modified thinset has been developed to enhance the strength of the bond in addition to improving working conditions of the material (i.e. working time, working temperature range, etc.). It is usually more expensive than standard, unmodified thinset. References External links How to Spread Thinset for Ceramic Tile. Accessed 14 June 2014. C-Cure ThinSet 911 Dry-Set Portland Cement Mortar. Accessed 14 June 2014. Soil-based building materials Cement Masonry