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https://en.wikipedia.org/wiki/Serre%27s%20conjecture
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Serre's conjecture may refer to:
Quillen–Suslin theorem, formerly known as Serre's conjecture
Serre's conjecture II (algebra), concerning the Galois cohomology of linear algebraic groups
Serre's modularity conjecture, concerning Galois representations
Serre's multiplicity conjectures in commutative algebra
Ribet's theorem, formerly known as Serre's epsilon conjecture
See also
Jean-Pierre Serre
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https://en.wikipedia.org/wiki/CKKQ-FM
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CKKQ-FM (100.3 The Q) is a broadcast radio station in Victoria, British Columbia, Canada. CKKQ broadcasts at a frequency of 100.3 MHz on the FM band. The station has broadcast a mainstream rock format since its inception, but has a more classic rock sound since 2001, when sister station CKXM AM/-FM became The Zone @ 91.3 with the CJZN calls and an alternative rock format. It used to have an adult album alternative lean up until Pattison took over the station from OK Radio.
The station placed 2nd in the fall 2018 Numeris Diary Survey for Victoria
History
In April 1987, the OK Radio Group Ltd. (known at the time as Victoria Communications Ltd.) was granted an FM radio license and launched 100.3 The Q, then known as Q-100, in December 1987. The first song played was The Rolling Stones' "Start Me Up".
In May 1999, CKKQ and sister station CKXM (formerly CKDA-AM) (now known as CJZN-FM (The Zone @ 91-3)) moved to the top floor of 2750 Quadra Street, a three-storey Victoria office building purchased by the OK Radio Group Ltd. in the fall of 1998.
Thanks to the prime position of CKKQ's transmitter on the Malahat Ridge, its signal reaches up Vancouver Island as far north as Nanaimo, onto the Lower Mainland as far east as Kent and into Washington as far south as Tacoma, on a good day. In 2000, CKKQ added a transmitter in Sooke on the frequency 94.7 FM with the callsign CKKQ-FM-1.
In 2001, CKKQ actually achieved a 0.1 share in the American Arbitron ratings for Seattle/Tacoma, placin
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https://en.wikipedia.org/wiki/Phytotoxicity
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Phytotoxicity describes any adverse effects on plant growth, physiology, or metabolism caused by a chemical substance, such as high levels of fertilizers, herbicides, heavy metals, or nanoparticles. General phytotoxic effects include altered plant metabolism, growth inhibition, or plant death. Changes to plant metabolism and growth are the result of disrupted physiological functioning, including inhibition of photosynthesis, water and nutrient uptake, cell division, or seed germination.
Fertilizers
High concentrations of mineral salts in solution within the plant growing medium can result in phytotoxicity, commonly caused by excessive application of fertilizers. For example, urea is used in agriculture as a nitrogenous fertilizer. However, if too much is applied, phytotoxic effects can result from urea toxicity directly or ammonia production from hydrolysis of urea. Organic fertilizers, such as compost, also have the potential to be phytotoxic if not sufficiently humified, as intermediate products of this process are harmful to plant growth.
Herbicides
Herbicides are designed and used to control unwanted plants such as agricultural weeds. However, the use of herbicides can cause phytotoxic effects on non-targeted plants through wind-blown spray drift or from the use of herbicide-contaminated material (such as straw or manure) being applied to the soil. Herbicides can also cause phytotoxicity in crops if applied incorrectly, in the wrong stage of crop growth, or in excess
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https://en.wikipedia.org/wiki/Friedrichs%27s%20inequality
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In mathematics, Friedrichs's inequality is a theorem of functional analysis, due to Kurt Friedrichs. It places a bound on the Lp norm of a function using Lp bounds on the weak derivatives of the function and the geometry of the domain, and can be used to show that certain norms on Sobolev spaces are equivalent. Friedrichs's inequality generalizes the Poincaré–Wirtinger inequality, which deals with the case k = 1.
Statement of the inequality
Let be a bounded subset of Euclidean space with diameter . Suppose that lies in the Sobolev space , i.e., and the trace of on the boundary is zero. Then
In the above
denotes the Lp norm;
α = (α1, ..., αn) is a multi-index with norm |α| = α1 + ... + αn;
Dαu is the mixed partial derivative
See also
Poincaré inequality
References
Sobolev spaces
Inequalities
Linear functionals
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https://en.wikipedia.org/wiki/Mason%27s%20theorem
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Mason's theorem may refer to either of the following:
The Mason–Stothers theorem, a mathematical theorem about polynomials
Mason's gain formula, a method for finding the transfer function of a linear signal-flow graph
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https://en.wikipedia.org/wiki/Crystal%20Lake%20%28Otter%20Tail%2C%20Minnesota%29
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Crystal Lake is a lake located in Lida Township in Otter Tail County, Minnesota, USA.
Size and shape
Crystal Lake is an almost circular lake, covering an area of and reaching a maximum depth of . Despite the said maximum depth, 51 percent of the lake is less than in depth.
Location
To the west is Lake Lizzie, which is connected to Crystal Lake by a navigable culvert under County Road 31. The larger Lake Lida lies close to the south of the lake, but is not connected directly. Smaller Lake Franklin is located to the northwest.
References
Lakes of Otter Tail County, Minnesota
Lakes of Minnesota
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https://en.wikipedia.org/wiki/Madrigueras
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Madrigueras is a municipality in Albacete, Castile-La Mancha, Spain. It has a population of 4,917 according to the official statistics by the National Statistics Institute of Spain (INE). The principal productions of this village are wine, knives and spatulas. Madrigueras is referred to as "Little China" due to the great number of inhabitants who use bikes for transportation.
References
External links
http://www.madrigueras.es Homepage of Madrigueras (in Spanish)
Municipalities of the Province of Albacete
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https://en.wikipedia.org/wiki/Paterna%20del%20Madera
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Paterna del Madera is a municipality in Albacete, Castile-La Mancha, Spain. It has a population of 528 people.
Municipalities of the Province of Albacete
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https://en.wikipedia.org/wiki/Lemke%20%28surname%29
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Lemke is a German surname.
Geographical distribution
As of 2014, 59.6% of all known bearers of the surname Lemke were residents of Germany (frequency 1:2,598), 27.7% of the United States (1:3,061,452), 4.6% of Brazil (1:86,475), 2.1% of Canada (1:33,211) and 2.1% of Poland (1:34,335).
In Germany, the frequency of the surname was higher than national average (1:2,598) in the following states:
1. Mecklenburg-Vorpommern (1:599)
2. Brandenburg (1:837)
3. Schleswig-Holstein (1:969)
4. Berlin (1:1,102)
5. Bremen (1:1,445)
6. Hamburg (1:1,642)
7. Lower Saxony (1:1,716)
8. Saxony-Anhalt (1:1,977)
People
Anthony Lemke, actor
Birsel Lemke, environmentalist
Carlton E. Lemke, mathematician
Helmut Lemke (1907-1990), German politician
James Lemke (born 1988), Australian professional tennis player
James U Lemke (1929–2019), American physicist and entrepreneur
Jay Lemke, education scientist
LeRoy Lemke (1935–1991), American lawyer and politician
Leslie Lemke, musical savant
Lev Lemke, actor
Mark Lemke, baseball player
Peter Henry Lemke, Benedictine
Richard R. Lemke (1930-2016), American farmer and politician
Siegfried Lemke, World War II Luftwaffe ace
Steffi Lemke (born 1968), German politician
Steve Lemke, guitar player
William Lemke, politician
Wolf Lemke, aircraft designer
Dave Lemke, original bass player of Imagine Dragons
References
German-language surnames
Surnames of German origin
de:Lemke (Begriffsklärung)
fr:Lemke
nl:Lemke
pl:Lemke
ru:Лемке
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https://en.wikipedia.org/wiki/List%20of%20Everton%20F.C.%20records%20and%20statistics
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Everton Football Club is a professional association football club located in Liverpool. The club was formed in 1878, and was originally named as St Domingo FC. The club's first game was a 1–0 victory over Everton Church Club. In November 1879 the club was renamed to Everton FC.
In 1888, Everton were one of the twelve founding members of the English Football League. The club have played in the top-flight of English Football for a record 117 years, having missed only four top-flight seasons (1930–31, 1951–52, 1952–53, 1953–54).
Major competitions won by Everton F.C., records set by the club, associated managers and players will be included in the following list.
The player records section includes: appearances, goals scored, and clean sheets kept. Player and manager awards, transfer fees, club records (Wins, Draws, and Losses) are all included in the list, as well as several others.
Honours
Domestic
First Division:
Titles (9): 1890–91, 1914–15, 1927–28, 1931–32, 1938–39, 1962–63, 1969–70, 1984–85, 1986–87
Second Division:
Titles (1): 1930–31
FA Cup:
Titles (5): 1905–06, 1932–33, 1965–66, 1983–84, 1994–95
Football League Cup:
Runner-up (2): 1976–77, 1983–84
FA Charity Shield:
Titles (9): 1928, 1932, 1963, 1970, 1984, 1985, 1986 (shared), 1987, 1995
Full Members Cup:
Runner-up (2): 1989, 1991
Football League Super Cup:
Runner-up (1): 1985–86
European
European Cup Winners' Cup:
Winners: (1): 1984–85
Doubles
1984–85: League and European Cup Winners' Cup
Awards
198
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https://en.wikipedia.org/wiki/Comparison%20theorem
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In mathematics, comparison theorems are theorems whose statement involves comparisons between various mathematical objects of the same type, and often occur in fields such as calculus, differential equations and Riemannian geometry.
Differential equations
In the theory of differential equations, comparison theorems assert particular properties of solutions of a differential equation (or of a system thereof), provided that an auxiliary equation/inequality (or a system thereof) possesses a certain property.
Chaplygin inequality
Grönwall's inequality, and its various generalizations, provides a comparison principle for the solutions of first-order ordinary differential equations.
Sturm comparison theorem
Aronson and Weinberger used a comparison theorem to characterize solutions to Fisher's equation, a reaction--diffusion equation.
Hille-Wintner comparison theorem
Riemannian geometry
In Riemannian geometry, it is a traditional name for a number of theorems that compare various metrics and provide various estimates in Riemannian geometry.
Rauch comparison theorem relates the sectional curvature of a Riemannian manifold to the rate at which its geodesics spread apart.
Toponogov's theorem
Myers's theorem
Hessian comparison theorem
Laplacian comparison theorem
Morse–Schoenberg comparison theorem
Berger comparison theorem, Rauch–Berger comparison theorem
Berger–Kazdan comparison theorem
Warner comparison theorem for lengths of N-Jacobi fields (N being a submanifold of a complet
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https://en.wikipedia.org/wiki/Separation%20theorem
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Separation theorem may refer to several theorems in different scientific fields.
Economics
Fisher separation theorem (corporation theory) - asserts that the objective of a corporation will be the maximization of its present value, regardless of the preferences of its shareholders.
Mutual fund separation theorem (portfolio theory) states that, under certain conditions, any investor's optimal portfolio can be constructed by holding each of certain mutual funds in appropriate ratios, where the number of mutual funds is smaller than the number of individual assets in the portfolio.
Mathematics
Gabbay's separation theorem (mathematical logic and computer science) states that any arbitrary temporal logic formula can be rewritten in a logically equivalent "past → future" form.
Planar separator theorem (graph theory) states that any planar graph can be split into smaller pieces by removing a small number of vertices.
Lusin's separation theorem (descriptive set theory) states that for any two disjoint analytic subsets of a Polish space there is a Borel subset containing one but disjoint from the other.
Geometry
Hyperplane separation theorem - either of two theorems about disjoint convex sets in n-dimensional Euclidean space. Also known as: Separating axis theorem.
Geometric separator theorems - theorems regarding the existence of lines separating objects in the plane without harming too many of them.
Guillotine separation theorems - theorems regarding the possibility of se
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https://en.wikipedia.org/wiki/Nunc
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Nunc A/S of Denmark was founded in 1953. Nunc specialized in laboratory plastic ware including products for cell culture, cell biology assays, sample prep, and sample storage. The company merged with the Nalge Company, which was founded in 1949 by chemist Emanuel Goldberg of Rochester, New York in 1995.
References
Manufacturing companies of Denmark
Companies based in Roskilde Municipality
Danish companies established in 1949
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https://en.wikipedia.org/wiki/Neporadza%2C%20Rimavsk%C3%A1%20Sobota%20District
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Neporadza () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Potok%2C%20Rimavsk%C3%A1%20Sobota%20District
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Potok () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Padarovce
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Padarovce (, also Balogpádár) is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
Municipalities in Slovakia where Hungarian is an official language
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https://en.wikipedia.org/wiki/Tachty
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Tachty () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rumince
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Rumince () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rakytn%C3%ADk
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Rakytník () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Valice
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Valice () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Vlky%C5%88a
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Vlkyňa () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Str%C3%A1nska
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Stránska () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rimavsk%C3%A9%20Janovce
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Rimavské Janovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Transfersome
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Transfersome is a proprietary drug delivery technology, an artificial vesicle designed to exhibit the characteristics of a cell vesicle suitable for controlled and potentially targeted drug delivery. Some evidence has shown efficacy for its use for drug delivery without causing skin irritation, potentially being used to treat skin cancer. Transfersome is made by the German company IDEA AG.
References
Cell biology
Nanomedicine
Drug delivery devices
Dosage forms
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https://en.wikipedia.org/wiki/FDOA
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Frequency difference of arrival (FDOA) or differential Doppler (DD), is a technique analogous to TDOA for estimating the location of a radio emitter based on observations from other points. (It can also be used for estimating one's own position based on observations of multiple emitters). TDOA and FDOA are sometimes used together to improve location accuracy and the resulting estimates are somewhat independent. By combining TDOA and FDOA measurements, instantaneous geolocation can be performed in two dimensions.
It differs from TDOA in that the FDOA observation points must be in relative motion with respect to each other and the emitter. This relative motion results in different doppler shifts observations of the emitter at each location in general. The relative motion can be achieved by using airborne observations in aircraft, for example. The emitter location can then be estimated with knowledge of the observation points' location and vector velocities and the observed relative doppler shifts between pairs of locations.
A disadvantage of FDOA is that large amounts of data must be moved between observation points or to a central location to do the cross-correlation that is necessary to estimate the doppler shift.
The accuracy of the location estimate is related to the bandwidth of the emitter's signal, the signal-to-noise ratio at each observation point, and the geometry and vector velocities of the emitter and the observation points.
See also
Multilateration
Furthe
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https://en.wikipedia.org/wiki/Cryoablation
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Cryoablation is a process that uses extreme cold to destroy tissue. Cryoablation is performed using hollow needles (cryoprobes) through which cooled, thermally conductive, fluids are circulated. Cryoprobes are positioned adjacent to the target in such a way that the freezing process will destroy the diseased tissue. Once the probes are in place, the attached cryogenic freezing unit removes heat from ("cools") the tip of the probe and by extension from the surrounding tissues.
Ablation occurs in tissue that has been frozen by at least three mechanisms:
formation of ice crystals within cells thereby disrupting membranes, and interrupting cellular metabolism among other processes;
coagulation of blood thereby interrupting bloodflow to the tissue in turn causing ischemia and cell death; and
induction of apoptosis, the so-called programmed cell death cascade.
The most common application of cryoablation is to ablate solid tumors found in the lung, liver, breast, kidney and prostate. The use in prostate and renal cryoablation are the most common. Although sometimes applied in cryosurgery through laparoscopic or open surgical approaches, most often cryoablation is performed percutaneously (through the skin and into the target tissue containing the tumor) by a medical specialist, such as an interventional radiologist. The term is from cryo- + ablation.
Prostate
Prostate cryoablation is moderately effective but, as with any prostate removal process, also can result in impotence.
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https://en.wikipedia.org/wiki/List%20of%20towns%20and%20cities%20with%20100%2C000%20or%20more%20inhabitants
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By country name
A-B • C-D-E-F • G-H-I-J-K • L-M-N-O • P-Q-R-S • T-U-V-W-Y-Z
See also
List of largest cities
Notes
References
Sources
Population Density, United Nations Statistics Division, accessed 30 August 2010.
External links
Geopolis: research group, university of Paris-Diderot, France
Towns and cities with 100,000 or more inhabitants
100,000 or more inhabitants
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https://en.wikipedia.org/wiki/Nov%C3%A1%20Ba%C5%A1ta
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Nová Bašta () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Aiguilles%20Rouges
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The Aiguilles Rouges ("Red Needles") are a crystalline mountainous massif of the French Prealps, opposite the Mont Blanc Massif. The colour of the iron rich gneiss (metamorphique) mountains gives the range its name. The highest summit is the Aiguille du Belvédère at . At the southern end of the range, Le Brévent at is accessible by a cable car in the Planpraz and the Brévent sections.
Morphology
Unlike the massif of the Mont Blanc, the Aiguilles Rouges have no significant glaciers. The alpine stage begins around with rough boulders, above which a series of broken needles spring from the Col des Montets to Le Brévent. The northwestern side of the massif has less vegetation because of its lack of exposure to the sun. The southwest face abounds in vegetation which developed from a multitude of biotopes. Amongst the typical flora hikers can discover include sundews, martagons and many varieties of orchids. In order to protect this biodiversity, the Aiguilles Rouges National Nature Reserve (Réserve naturelle des aiguilles rouges) was created in 1974 covering 3,279 ha.
The Aiguilles Rouges offer a splendid view of all the peaks of Chamonix, the glaciers of Mont Blanc, and the roof of Europe. The French artist Samivel is known for his paintings of some of these splendid views. The highest point in this range is named Belvédère (literally "beautiful viewpoint" in French) because it offers a 360° panoramic view of all the mountains surrounding the Aiguilles Rouges. The mountai
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https://en.wikipedia.org/wiki/Gap%20of%20Dunloe
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The Gap of Dunloe (), also recorded as Bearna an Choimín (meaning "gap of the commonage" or "gap of the little hollow"), is a narrow mountain pass running north-south in County Kerry, Ireland, that separates the MacGillycuddy's Reeks mountain range in the west, from the Purple Mountain Group range in the east. It is one of Kerry's most popular tourist destinations on account of its scenery.
Naming
The term "Dunloe" is believed to be an anglicisation of the Irish term "Dún Lóich", meaning fort or stronghold of Lóich (the River Loe that runs through the Gap of Dunloe valley also derives its name from the same source). According to the Annals of Clonmacnois, Keating and the Lebor Gabála Érenn (LGE), Deala (or Dela) Mac Lóich was the father of the five chieftains of the returning Fir Bolg (Slainghe, Gann, Genann, Seangann, and Rudhraighe), who conquered Ireland and divided it into five provinces, each ruled by one brother. According to the Annals of the Four Masters, the Fir Bolg ruled Ireland for 37 years from 3266 to 3303 BCE, but were themselves defeated by the returning Tuatha Dé Danann.
Geography
The Gap of Dunloe was formed 25,000 years ago during Ireland's last ice age as a result of a "glacial breach" where a glacier in the Black Valley, part of the Templenoe Icecap, estimated to be over 500 metres deep, broke through the Head of the Gap and moved northwards carving out a U-shaped valley.
The pass runs north-south between the Old Red Sandstone mountain ranges of t
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https://en.wikipedia.org/wiki/United%20Kingdom%20Standard%20Industrial%20Classification%20of%20Economic%20Activities
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The United Kingdom Standard Industrial Classification of Economic Activities (UKSIC) is a Standard Industrial Classification that is intended to help classify businesses according to the type of their economic activity. One or more SIC codes can be attributed to a business. SIC codes identify what a business does.
Over time there have been several different SIC systems used in the UK, with versions published in 1958, 1968, 1980, 1992, 1997, 2003 and 2007. These taxonomies have been adapted to cope with the changes in UK industry, The 1980 system was far more detailed in manufacturing, while the 2007 system is much stronger in the IT sector. Many companies still use the 2003 codes which were the 1992 system updated slightly. However, the very latest version is the 2007 SIC system
History
A Standard Industrial Classification (SIC) was first introduced into the United Kingdom in 1948 for use in classifying business establishments and other statistical units by the type of economic activity in which they are engaged. The classification provides a framework for the collection, tabulation, presentation and analysis of data and its use promotes uniformity. In addition, it can be used for administration purposes and by non-government bodies as a convenient way of classifying industrial activities into a common structure.
Current 2007 SIC codes
These now fall in line with the European Union industrial classification system, NACE, and the United Nations International Standard Indust
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https://en.wikipedia.org/wiki/Graef%20Crystal
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Graef "Bud" S. Crystal was an expert on executive compensation, often cited as a critic of excessive packages.
He started work as an executive compensation consultant in 1959. He worked for twenty years at the consulting firm Towers Perrin, and also taught at the Haas School of Business. He advised on pay at Coca-Cola Company and American Express.
He authored books on executive compensation as both an advisor and critic. He wrote a column on Bloomberg, and subsequently published on his own website.
Selected works
Compensating U.S. Executives Abroad (1972)
Executive Compensation: Money, Motivation, and Imagination (1978)
Financial Motivation For Executives (1978)
Questions and Answers on Executive Compensation: How to Get What You're Worth (1984)
In Search of Excess: The Overcompensation of American Executives (1991)
References
External links
The Crystal Report on Executive Compensation
Year of birth missing (living people)
Living people
American business writers
Haas School of Business faculty
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https://en.wikipedia.org/wiki/Nikon%20Coolpix%20S4
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The Coolpix S4 is a brand of digital camera produced by Nikon. Its image sensor is a CCD with 6.0 million pixels. It has a thin-film transistor liquid crystal display device with 110,000 pixels. The S4 incorporates Nikon's popular swivel design which allows the addition of a powerful Nikkor 10X Optical zoom lens, yet retain a compact form. Other features include D-Lighting and Face-priority AF.
Nikon later released the Nikon Coolpix S10 which has a similar 10x swivel lens design as the S4, but with more advanced features such as vibration reduction and a lithium ion battery.
See also
Nikon Coolpix S1
Nikon Coolpix S3
Nikon Coolpix S10
Nikon Coolpix 950
Nikon Coolpix 995
Nikon Coolpix 4500
References
"Nikon Coolpix S4"
External links
Nikon product archives: "Nikon Coolpix S4"
S0004
Digital cameras with CCD image sensor
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https://en.wikipedia.org/wiki/Rumble
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Rumble or Rumbling may refer to:
Companies
Rumble (company), video hosting service
Sounds and vibrations
Rumble (noise), a form of low frequency noise
Rumble, a haptic feedback vibration feature in video game controllers
Rumbling, a quality of a heart murmur
Stomach rumble, or borborygmus, a medical term
Places
Rumble, Shetland, an islet group off Whalsay, Scotland, UK
Rumble, Indiana, US
Rumble, West Virginia, US
People
Anthony Johnson (fighter), an American mixed martial artist nicknamed Rumble
Dane Rumble (born 1982), New Zealand recording artist
Darren Rumble (Australian rules footballer) (born 1984), Fremantle draftee
Darren Rumble (ice hockey) (born 1969), Canadian ice hockey player and coach
Mark Rumble, British television presenter on Studio Disney UK
Paul Rumble (born 1969), English footballer
Terry Rumble (born 1942), Australian politician
Tony Rumble (1956–1999), American professional wrestler
Mike Rumbles (born 1956), Scottish politician
Arts and entertainment
Films and television
Rumble (2002 film), a Finnish film directed by Jani Volanen
Rumble (2016 film), a Mexican film directed by R. Ellis Frazier
Rumble: The Indians Who Rocked the World, a 2017 Canadian documentary
Rumble (2021 film), an American film directed by Hamish Grieve
Rumble (TV series), a short-lived British sitcom; see 1995 in British television#BBC1
Music
Albums
The Rumble (Abhinanda album), 1999
The Rumble (N2Deep album), 1998
Songs
"Rumble", by KDA, later rew
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https://en.wikipedia.org/wiki/Dennis%20DeTurck
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Dennis M. DeTurck (born July 15, 1954) is an American mathematician known for his work in partial differential equations and Riemannian geometry, in particular contributions to the theory of the Ricci flow and the prescribed Ricci curvature problem. He first used the DeTurck trick to give an alternative proof of the short time existence of the Ricci flow, which has found other uses since then.
Education
DeTurck received a B.S. (1976) from Drexel University. He received an M.A. (1978) and Ph.D. (1980) in mathematics from the University of Pennsylvania. His Ph.D. supervisor was Jerry Kazdan.
Career
DeTurck is currently Robert A. Fox Leadership Professor and Professor of Mathematics at the University of Pennsylvania, where he has been the Dean of the College of Arts and Sciences since 2005 and Faculty Director of Riepe College House. In 2002, DeTurck won the Haimo Award from the Mathematical Association of America for his teaching. Despite being recognized for excellence in teaching, he has been criticized for his belief that fractions are "as obsolete as Roman numerals" and suggesting that they not be taught to younger students.
In January 2012, he shared the Chauvenet Prize with three mathematical collaborators. In 2012, he became a fellow of the American Mathematical Society.
Selected publications
(explains the DeTurck trick; also see the improved version)
References
External links
Article with some career and biographical info
Dennis DeTurck's homepage
1954 births
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https://en.wikipedia.org/wiki/Edna%20Grossman
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Edna Grossman (born Edna Kalka) is an American mathematician. She was born in Germany, grew up in Brooklyn, New York, and graduated with a B.S. in mathematics from Brooklyn College. She earned her M.S. in mathematics from New York University's Courant Institute of Mathematical Sciences, where she also received her Ph.D. in mathematics in 1972; her thesis, supervised by Wilhelm Magnus, concerned the symmetries of free groups. Grossman worked for IBM, where she was part of the team that designed and analyzed the Data Encryption Standard. She is known for her development, along with Bryant Tuckerman, of the first slide attack in cryptanalysis.
References
20th-century American mathematicians
21st-century American mathematicians
American cryptographers
American women mathematicians
Group theorists
Brooklyn College alumni
Courant Institute of Mathematical Sciences alumni
Living people
Year of birth missing (living people)
20th-century women mathematicians
21st-century women mathematicians
20th-century American women
21st-century American women
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https://en.wikipedia.org/wiki/The%20Crystal%20Palace%20%28novel%29
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The Crystal Palace is the second novel in "The Book of Elementals" series by Phyllis Eisenstein. (The first novel Sorcerer's Son was first published as a mass market paperback from Del Rey Books in 1979.) The Crystal Palace was originally released in 1988 as a mass-market paperback from Signet. It was last in-print in both hardcover and trade paperback in the 2002 omnibus volume The Book of Elementals (with Sorcerer's Son) from Meisha Merlin Publishing. (Eisenstein completed the manuscript for the final volume in the trilogy, The City in Stone, but the novel was left unpublished after Meisha Merlin suddenly ceased operations in 2007.)
Plot summary
Sorcerer Cray Ormoru and his friend, the seer Feldar Sepwin, craft an enchanted mirror that allows whoever gazes upon it to see their heart's desire. For Cray himself, the mirror remains blank for many years, until one day he sees in it the image of a young girl. With no idea of who she is, he watches the girl transform into a lovely woman over the years, and Cray realizes that he is destined to find her. When he does, he learns that this is Aliza, a sorceress who lives in a crystal palace which is partly within the demon realm and who is dedicated solely to the study of her craft.
Cray finds Aliza to be a skilled young sorceress, but also cold, aloof, and entirely focused on sorcery. Cray encourages her to take an interest in the outside world and forms a budding friendship. However, this friendship is strongly discouraged by Al
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https://en.wikipedia.org/wiki/Banana%20bag
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A banana bag (or rally pack) is a bag of IV fluids containing vitamins and minerals. The bags typically contain thiamine, folic acid, and magnesium sulfate, and are usually used to correct nutritional deficiencies or chemical imbalances in the human body. The solution has a yellow color, hence the term "banana bag".
A Banana Bag may also refer to an over the counter Banana Bag oral solution that is mixed with water and contains the same vitamins and electrolytes orally as the IV solution.
Composition
The typical composition of a banana bag is 1 liter of normal saline (sodium chloride 0.9%) with:
Thiamine 100 mg
Folic acid 1 mg
Multivitamin for infusion (MVI), 1 ampule
Magnesium sulfate 3 g
The solution is typically infused over four to eight hours or as per physician's orders. The yellow color comes from the riboflavin in the MVI and the folic acid. (The conventional composition is not optimal based on current evidence; see the Flannery et al. (2016) citation.)
Uses
Banana bags are often prescribed for alcoholics. Chronic alcoholism can lead to significant lack of thiamine, potentially causing Wernicke–Korsakoff syndrome. Chronic alcoholics can also suffer significant whole-body magnesium deficiencies. However, recent evidence (2016) points that the amount of thiamine in a conventional banana bag is inadequate for prophylaxis and treatment for ICU patients. The proposed regimen is 200–500 mg IV thiamine every eight hours for the first day of admission. Less evi
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https://en.wikipedia.org/wiki/Shallow%20trench%20isolation
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Shallow trench isolation (STI), also known as box isolation technique, is an integrated circuit feature which prevents electric current leakage between adjacent semiconductor device components. STI is generally used on CMOS process technology nodes of 250 nanometers and smaller. Older CMOS technologies and non-MOS technologies commonly use isolation based on LOCOS.
STI is created early during the semiconductor device fabrication process, before transistors are formed. The key steps of the STI process involve etching a pattern of trenches in the silicon, depositing one or more dielectric materials (such as silicon dioxide) to fill the trenches, and removing the excess dielectric using a technique such as chemical-mechanical planarization.
Certain semiconductor fabrication technologies also include deep trench isolation, a related feature often found in analog integrated circuits.
The effect of the trench edge has given rise to what has recently been termed the "reverse narrow channel effect" or "inverse narrow width effect". Basically, due to the electric field enhancement at the edge, it is easier to form a conducting channel (by inversion) at a lower voltage. The threshold voltage is effectively reduced for a narrower transistor width. The main concern for electronic devices is the resulting subthreshold leakage current, which is substantially larger after the threshold voltage reduction.
Process flow
Stack deposition (oxide + protective nitride)
Lithography print
Dry et
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https://en.wikipedia.org/wiki/NLRP3
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NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.
Nomenclature
NACHT, LRR, and PYD are respectively acronyms for:
NACHT – NAIP (neuronal apoptosis inhibitor protein), C2TA [class 2 transcription activator, of the MHC, HET-E (heterokaryon incompatibility) and TP1 (telomerase-associated protein 1)
LRR – "leucine-rich repeat" and is synonymous with NLR, for or nucleotide-binding domain, leucine-rich repeat"
PYD – "PYRIN domain," after the pyrin proteins The NLRP3 gene name abbreviates "NLR family, pyrin domain containing 3," where NLR refers to "nucleotide-binding domain, leucine-rich repeat."
The NACHT, LRR and PYD domains-containing protein 3 is also called:
cold induced autoinflammatory syndrome 1 (CIAS1),
caterpiller-like receptor 1.1 (CLR1.1), and
PYRIN-containing APAF1-like protein 1 (PYPAF1).
Structure
This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This pr
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https://en.wikipedia.org/wiki/Bombesin%20receptor
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The bombesin receptors are a group of G-protein coupled receptors which bind bombesin.
Three bombesin receptors are currently known:
BB1, previously known as Neuromedin B receptor
BB2, previously known as Gastrin-releasing peptide receptor
BB3, previously known as Bombesin-like receptor 3
External links
G protein-coupled receptors
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https://en.wikipedia.org/wiki/Calcitonin%20receptor
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The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.
CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).
Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.
Interactions
Calcitonin receptor has been shown to interact with Apolipoprotein B and LRP1.
References
Further reading
External links
G protein-coupled receptors
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https://en.wikipedia.org/wiki/Petrovce%2C%20Rimavsk%C3%A1%20Sobota%20District
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Petrovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Star%C3%A1%20Ba%C5%A1ta
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Stará Bašta () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Gromov%27s%20compactness%20theorem%20%28geometry%29
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In the mathematical field of metric geometry, Mikhael Gromov proved a fundamental compactness theorem for sequences of metric spaces. In the special case of Riemannian manifolds, the key assumption of his compactness theorem is automatically satisfied under an assumption on Ricci curvature. These theorems have been widely used in the fields of geometric group theory and Riemannian geometry.
Metric compactness theorem
The Gromov–Hausdorff distance defines a notion of distance between any two metric spaces, thereby setting up the concept of a sequence of metric spaces which converges to another metric space. This is known as Gromov–Hausdorff convergence. Gromov found a condition on a sequence of compact metric spaces which ensures that a subsequence converges to some metric space relative to the Gromov–Hausdorff distance:
Let be a sequence of compact metric spaces with uniformly bounded diameter. Suppose that for every positive number there is a natural number and, for every , the set can be covered by metric balls of radius . Then the sequence has a subsequence which converges relative to the Gromov–Hausdorff distance.
The role of this theorem in the theory of Gromov–Hausdorff convergence may be considered as analogous to the role of the Arzelà–Ascoli theorem in the theory of uniform convergence. Gromov first formally introduced it in his 1981 resolution of the Milnor–Wolf conjecture in the field of geometric group theory, where he applied it to define the asymptotic co
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https://en.wikipedia.org/wiki/Gromov%27s%20compactness%20theorem%20%28topology%29
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In the mathematical field of symplectic topology, Gromov's compactness theorem states that a sequence of pseudoholomorphic curves in an almost complex manifold with a uniform energy bound must have a subsequence which limits to a pseudoholomorphic curve which may have nodes or (a finite tree of) "bubbles". A bubble is a holomorphic sphere which has a transverse intersection with the rest of the curve. This theorem, and its generalizations to punctured pseudoholomorphic curves, underlies the compactness results for flow lines in Floer homology and symplectic field theory.
If the complex structures on the curves in the sequence do not vary, only bubbles can occur; nodes can occur only if the complex structures on the domain are allowed to vary. Usually, the energy bound is achieved by considering a symplectic manifold with compatible almost-complex structure as the target, and assuming that curves to lie in a fixed homology class in the target. This is because the energy of such a pseudoholomorphic curve is given by the integral of the target symplectic form over the curve, and thus by evaluating the cohomology class of that symplectic form on the homology class of the curve. The finiteness of the bubble tree follows from (positive) lower bounds on the energy contributed by a holomorphic sphere.
References
Symplectic topology
Compactness theorems
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https://en.wikipedia.org/wiki/Daz%20Eden
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Daz Eden is a fictional character from the British ITV soap opera Emmerdale, played by Luke Tittensor. He made his first appearance in the show on 9 October 2003. Six years into his tenure on the soap, it was announced that Tittensor had been released from Emmerdale due to a conviction of grievous bodily harm. Following a meeting with the show's bosses, the decision was taken to terminate Tittensor's contract due to the serious nature of the charge and to allow him to focus on the court case.
Casting
Luke Tittensor was cast as Daz and made his first appearance in October 2003. At the age of 19, Tittensor was charged with grievous bodily harm after he attacked a 16-year-old. Since he pleaded guilty to the crime and due to the serious nature of the charge, ITV felt they "had no choice but to let the actor go". ITV also wanted to "enable him to focus on the court case". In a statement, ITV said: "As Luke has pleaded guilty to the serious charge of GBH and we cannot condone criminal behaviour, we have met with Luke and his agent to explain his contract with Emmerdale will be terminated. Luke regrets his behaviour and understands this situation." Jess Grieveson-Smith of Leeds Live wrote that ITV's sacking had been "unceremonious". His final scenes aired on 24 April 2009.
Storylines
Daz was initially a troublemaker as he had a history of stealing cars but tried to make amends with community service. Unfortunately, things didn't go according to plan. Katie used this to her advant
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https://en.wikipedia.org/wiki/Etynodiol
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Etynodiol, or ethynodiol, is a steroidal progestin of the 19-nortestosterone group which was never marketed. A diacylated derivative, etynodiol diacetate, is used as a hormonal contraceptive. Etynodiol is sometimes used as a synonym for etynodiol diacetate.
It was patented in 1955.
Pharmacology
Etynodiol is a prodrug of norethisterone, and is converted immediately and completely into norethisterone. Etynodiol is an intermediate in the conversion of the prodrug lynestrenol into norethisterone.
Chemistry
Etynodiol is a 19-nortestosterone derivative. Structurally, it is almost identical to norethisterone and lynestrenol, differing only in its C3 substituent. Whereas norethisterone has a ketone at C3 and lynestrenol has no substituent at C3, etynodiol has a hydroxyl group at the position.
Synthesis
Society and culture
Generic names
Etynodiol is the generic name of the drug and its , while ethynodiol is its .
References
Ethynyl compounds
Androgens and anabolic steroids
Diols
Estranes
Prodrugs
Progestogens
Synthetic estrogens
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https://en.wikipedia.org/wiki/Medroxyprogesterone
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Medroxyprogesterone (MP), is a progestin which is not used medically. A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.
Pharmacology
Pharmacodynamics
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.
Chemistry
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position. The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol.
Society and culture
Generic names
Medroxyprogesterone is the generic name of the drug and its and .
Brand Name
Meprate 10 Tablets (practo)
References
Abandoned drugs
Tertiary alcohols
Alkene derivatives
Diketones
Pregnanes
Proges
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https://en.wikipedia.org/wiki/Doun%20Kaev%20%28town%29
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Doun Kaev ( ; lit. "Crystal Grandmother") is the capital of Takéo Province, Cambodia. In 1998 it had a population of 39,186. The town and province is known for silk weaving, and the province is home to about 10,000 of the total of 15,000 Cambodian weavers. Most silk weavers in the villages are near the national highway in the direction of Takéo town. The technique of silk weaving could have come to the Khmer during the Kingdom of Funan, probably in the 2nd century, from India and China.
Notable people
Pen Sovan (1936–2016), former Prime Minister of Cambodia
Chinary Ung (born 1942), composer
References
Populated places in Takéo province
Provincial capitals in Cambodia
Cities in Cambodia
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https://en.wikipedia.org/wiki/Equilibrium%20unfolding
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In biochemistry, equilibrium unfolding is the process of unfolding a protein or RNA molecule by gradually changing its environment, such as by changing the temperature or pressure, pH, adding chemical denaturants, or applying force as with an atomic force microscope tip. If the equilibrium was maintained at all steps, the process theoretically should be reversible during equilibrium folding. Equilibrium unfolding can be used to determine the thermodynamic stability of the protein or RNA structure, i.e. free energy difference between the folded and unfolded states.
Theoretical background
In its simplest form, equilibrium unfolding assumes that the molecule may belong to only two thermodynamic states, the folded state (typically denoted N for "native" state) and the unfolded state (typically denoted U). This "all-or-none" model of protein folding was first proposed by Tim Anson in 1945, but is believed to hold only for small, single structural domains of proteins (Jackson, 1998); larger domains and multi-domain proteins often exhibit intermediate states. As usual in statistical mechanics, these states correspond to ensembles of molecular conformations, not just one conformation.
The molecule may transition between the native and unfolded states according to a simple kinetic model
N U
with rate constants and for the folding (U -> N) and unfolding (N -> U) reactions, respectively. The dimensionless equilibrium constant can be used to determine the conformational stabi
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https://en.wikipedia.org/wiki/Flow%20birefringence
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In biochemistry, flow birefringence is a hydrodynamic technique for measuring the rotational diffusion constants (or, equivalently, the rotational drag coefficients). The birefringence of a solution sandwiched between two concentric cylinders is measured as a function of the difference in rotational speed between the inner and outer cylinders. The flow tends to orient an ellipsoidal particle (typically, a protein, virus, etc.) in one direction, whereas rotational diffusion (tumbling) causes the molecule to become disoriented. The equilibrium between these two processes as a function of the flow provides a measure of the axial ratio of the ellipsoidal particle.
See also
Perrin friction factors
Protein structure
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https://en.wikipedia.org/wiki/Vorozole
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Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.
References
Aromatase inhibitors
Benzotriazoles
Chloroarenes
Triazoles
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https://en.wikipedia.org/wiki/List%20of%20municipalities%20in%20Rio%20Grande%20do%20Norte
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Rio Grande do Norte () is a state located in the Northeast Region of Brazil. According to the 2010 Census conducted by the Brazilian Institute of Geography and Statistics (IBGE), Rio Grande do Norte has a population of 3,168,133 inhabitants over , which makes it the 16th largest state by population and the 22nd largest by area, out of 26 states. It is home to cities such as Natal, Mossoró, and São Gonçalo do Amarante.
The land that became Rio Grande do Norte was a donatário to João de Barros, the factor of the House of India and Mina, from John III of Portugal in 1535; prior to that, the Portuguese Crown owned the land. The French, who trafficked Brazil wood in the area, had a foothold on the land until the Portuguese expelled them in 1598. The Dutch took the land in 1634 as a part of Dutch Brazil and reigned until 1654, when they were defeated by the Portuguese. In 1701, Rio Grande do Norte joined the Captaincy of Pernambuco, and became a province in 1822 and a state of Brazil in 1889.
Rio Grande do Norte is divided into 167 municipalities, which are grouped into four mesoregions and 23 microregions. Of the 167 municipalities, Natal has the highest population, with 803,811 inhabitants, while Viçosa, with 1,618 inhabitants, has the lowest. The largest municipality by area is Mossoró, with an area of ; the smallest is Senador Georgino Avelino, named after the former Senator and Rio Grande do Norte Governor José Georgino Avelino, which covers an area of .
Municipalities
See
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https://en.wikipedia.org/wiki/Mark%20N.%20Wegman
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Mark N. Wegman is an American computer scientist known for his contributions to algorithms and compiler optimization. Wegman received his B.A. from New York University and his Ph.D. from the University of California, Berkeley. He joined IBM Research in 1975, where he currently serves as head of Computer Science. He is a member of the IBM Academy of Technology and a Fellow of the Association for Computing Machinery (1996) and the Institute of Electrical and Electronics Engineers. He became an IBM Fellow in 2007. He was elected to the National Academy of Engineering in 2010.
Wegman is best known for being one of the inventors of the Static single assignment form, which is used in the analysis portion of most if not all modern optimizing compilers. This work was recognized by SIGPLAN in 2006 with its Programming Languages Achievement Award. He has also made contributions to algorithms and information theory including universal hashing and the LZMW data compression algorithm.
References
External links
IBM profile
American computer scientists
IBM employees
Fellows of the Association for Computing Machinery
Fellow Members of the IEEE
IBM Fellows
Members of the United States National Academy of Engineering
Living people
IBM Research computer scientists
Year of birth missing (living people)
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https://en.wikipedia.org/wiki/New%20Smyrna%20Sugar%20Mill%20Ruins
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The New Smyrna Sugar Mill Ruins (also known as the Cruger and DePeyster Sugar Mill) is a historic site in New Smyrna Beach, Florida, at 600 Old Mission Road, one mile west of the Intracoastal Waterway. On August 12, 1970, it was added to the U.S. National Register of Historic Places.
In 1830, a steam-operated sugarcane mill and a sawmill were erected at this site. The mills' masonry buildings were constructed of coquina, a sedimentary rock composed of fossilized tiny mollusc shells, quarried nearby. The structures included a crushing house, with a chimney and large arched doors and window openings, which contained the steam-driven grinding machinery that extracted the juice from the sugarcane. The entire process was carried out using slave labor and draft animals, under the management of the plantation overseer, John Dwight Sheldon.
On Christmas Day in 1835, the mills and other buildings were destroyed by Native Americans during the Second Seminole War; only the walls were left standing, with the machinery inside them, made by the West Point Foundry of Cold Spring, New York, mostly undamaged. The site was further altered by soldiers who were garrisoned there to keep the Seminoles under surveillance.
History
In 1830, William Kemble contracted to build a steam-operated sugarcane mill and a saw mill here for William DePeyster and Henry Cruger, merchant speculators from New York. Eliza Cruger, Henry Cruger's wife, and outside investors financed the construction of the mills o
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https://en.wikipedia.org/wiki/Ross%20Hammock%20Site
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The Ross Hammock Site is a historic site nine miles south of New Smyrna Beach, Florida. It is located inland from the Intracoastal Waterway on A1A within the Canaveral National Seashore. On February 5, 1981, it was added to the U.S. National Register of Historic Places.
References
External links
Volusia County listings at National Register of Historic Places
Florida's Office of Cultural and Historical Programs
Volusia County listings
Ross Hammock Site
Native American history of Florida
Archaeological sites in Florida
National Register of Historic Places in Volusia County, Florida
Protected areas established in 1981
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https://en.wikipedia.org/wiki/Tower%20rule
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The tower rule may refer to one of two rules in mathematics:
Law of total expectation, in probability and stochastic theory
a rule governing the degree of a field extension of a field extension in field theory
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https://en.wikipedia.org/wiki/Extensor%20retinaculum%20of%20the%20hand
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The extensor retinaculum (dorsal carpal ligament, or posterior annular ligament) is a thickened portion of the antebrachial fascia that holds the tendons of the extensor muscles in place. It is located on the back of the forearm, just proximal to the hand. It is continuous with the palmar carpal ligament (which is located on the anterior side of the forearm).
Structure
The extensor retinaculum is a strong, fibrous band, extending obliquely downward and medialward across the back of the wrist. It consists of part of the deep fascia of the back of the forearm, strengthened by the addition of some transverse fibers.
Relations
There are six separate synovial sheaths run beneath the extensor retinaculum: (1st) abductor pollicis longus and extensor pollicis brevis tendons, (2nd) extensor carpi radialis lungus and brevis tendons, (3rd) extensor pollicis longus tendon, (4th) extensor digitorium communis and extensor indicis proprius tendons, (5th) extensor digiti minimi tendon and (6th) extensor carpi ulnaris tendon.
On the dorsal side of the hand, the palmar carpal ligament corresponds in location and structure to the extensor retinaculum, both being formations of the antebrachial fascia and therefore continuous. Consequently, the flexor retinaculum is commonly referred to as the transverse carpal ligament to avoid confusion.
Histology
Structurally, the retinaculum consists of three layers. The deepest layer, the gliding layer, consists of hyaluronic acid-secreting cells. The
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https://en.wikipedia.org/wiki/Sample-continuous%20process
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In mathematics, a sample-continuous process is a stochastic process whose sample paths are almost surely continuous functions.
Definition
Let (Ω, Σ, P) be a probability space. Let X : I × Ω → S be a stochastic process, where the index set I and state space S are both topological spaces. Then the process X is called sample-continuous (or almost surely continuous, or simply continuous) if the map X(ω) : I → S is continuous as a function of topological spaces for P-almost all ω in Ω.
In many examples, the index set I is an interval of time, [0, T] or [0, +∞), and the state space S is the real line or n-dimensional Euclidean space Rn.
Examples
Brownian motion (the Wiener process) on Euclidean space is sample-continuous.
For "nice" parameters of the equations, solutions to stochastic differential equations are sample-continuous. See the existence and uniqueness theorem in the stochastic differential equations article for some sufficient conditions to ensure sample continuity.
The process X : [0, +∞) × Ω → R that makes equiprobable jumps up or down every unit time according to
is not sample-continuous. In fact, it is surely discontinuous.
Properties
For sample-continuous processes, the finite-dimensional distributions determine the law, and vice versa.
See also
Continuous stochastic process
References
Stochastic processes
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https://en.wikipedia.org/wiki/Kolmogorov%20extension%20theorem
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In mathematics, the Kolmogorov extension theorem (also known as Kolmogorov existence theorem, the Kolmogorov consistency theorem or the Daniell-Kolmogorov theorem) is a theorem that guarantees that a suitably "consistent" collection of finite-dimensional distributions will define a stochastic process. It is credited to the English mathematician Percy John Daniell and the Russian mathematician Andrey Nikolaevich Kolmogorov.
Statement of the theorem
Let denote some interval (thought of as "time"), and let . For each and finite sequence of distinct times , let be a probability measure on Suppose that these measures satisfy two consistency conditions:
1. for all permutations of and measurable sets ,
2. for all measurable sets ,
Then there exists a probability space and a stochastic process such that
for all , and measurable sets , i.e. has as its finite-dimensional distributions relative to times .
In fact, it is always possible to take as the underlying probability space and to take for the canonical process . Therefore, an alternative way of stating Kolmogorov's extension theorem is that, provided that the above consistency conditions hold, there exists a (unique) measure on with marginals for any finite collection of times . Kolmogorov's extension theorem applies when is uncountable, but the price to pay
for this level of generality is that the measure is only defined on the product σ-algebra of , which is not very rich.
Explanation of the conditions
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https://en.wikipedia.org/wiki/HSF
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HSF may refer to:
Hazara Student Federation, in Pakistan
Heat shock factor, a protein transcription factor
Human Social Functioning
Hellenic Sailing Federation, Greece
Herbert Smith Freehills, a law firm
Home Service Force, of the British Army
Homer Stryker Field, a stadium in Kalamazoo, Michigan, United States
Houston Shakespeare Festival, Texas, US
IATA code of Suifenhe Airport
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https://en.wikipedia.org/wiki/Disk%20diffusion%20test
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The disk diffusion test (also known as the agar diffusion test, Kirby–Bauer test, disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test and KB test) is a culture-based microbiology assay used in diagnostic and drug discovery laboratories. In diagnostic labs, the assay is used to determine the susceptibility of bacteria isolated from a patient's infection to clinically approved antibiotics. This allows physicians to prescribe the most appropriate antibiotic treatment. In drug discovery labs, especially bioprospecting labs, the assay is used to screen biological material (e.g. plant extracts, bacterial fermentation broths) and drug candidates for antibacterial activity. When bioprospecting, the assay can be performed with paired strains of bacteria to achieve dereplication and provisionally identify antibacterial mechanism of action.
In diagnostic laboratories, the test is performed by inoculating the surface of an agar plate with bacteria isolated from a patient's infection. Antibiotic-containing paper disks are then applied to the agar and the plate is incubated. If an antibiotic stops the bacteria from growing or kills the bacteria, there will be an area around the disk where the bacteria have not grown enough to be visible. This is called a zone of inhibition. The susceptibility of the bacterial isolate to each antibiotic can then be semi-quantified by comparing the size of these zones of inhibition to databases of information on
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https://en.wikipedia.org/wiki/TCGA
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TCGA may refer to:
The Cancer Genome Atlas
The Center for Genetic Anthropology at University College London
Taxation of Chargeable Gains Act 1992
Thomas Cook Group Airlines Limited - entered compulsory liquidation 23 September 2019
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https://en.wikipedia.org/wiki/Italian%20society%20of%20economics%20demography%20and%20statistics
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The Italian society of economics demography and statistics (SIEDS, ) is a learned society aiming to further economic, demographic, and statistical studies and to establish active co-operation among professionals of the mentioned subjects in the field of social sciences and human behaviour. The society pursues this aim by:
organising seminars, congresses, or scientific meetings for analysing and discussing problems concerning its activity;
implementing scientific surveys, enquires and researches and promoting, training activities (courses, seminars, etc.);
publishing the Rivista italiana di economia demografia e statistica, a series of studies and monographs on specific items concerning the scientific interest of the society, as well as the proceedings of its congresses and seminars.
History
SIEDS was founded on June 29, 1939, at the initiative of Livio Livi and others. The first seat of the society was located in Florence. Initially named "Italian Society of Demography and Statistics", it originated in the Advisory Committee for the Population Study (), also founded by Livi. The first publications of the society were only the scientific meeting proceedings but, starting from January 1947, the society published its own scientific journal, the Rivista italiana di economia demografia e statistica. On 18 April 1950 the society decided to expand its fields of interest also to economics and obtained its current name. In 1950 the society's journal was renamed accordingly to Italia
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https://en.wikipedia.org/wiki/Gallium%20phosphate
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Gallium phosphate (GaPO4 or gallium orthophosphate) is a colorless trigonal crystal with a hardness of 5.5 on the Mohs scale. GaPO4 is isotypic with quartz, possessing very similar properties, but the silicon atoms are alternately substituted with gallium and phosphorus, thereby doubling the piezoelectric effect. GaPO4 has many advantages over quartz for technical applications, like a higher electromechanical coupling coefficient in resonators, due to this doubling.
Contrary to quartz, GaPO4 is not found in nature. Therefore, a hydrothermal process must be used to synthesize the crystal.
Modifications
GaPO4 possesses, in contrast to quartz, no α-β phase transition, thus the low temperature structure (structure like α-quartz) of GaPO4 is stable up to 970°C, as are most of its other physical properties. Around 970°C another phase transition occurs which changes the low quartz structure into another structure similar with cristobalite.
Structure
The specific structure of GaPO4 shows the arrangement of tetrahedrons consisting of GaO4 and PO4 that are slightly tilted. Because of the helical arrangement of these tetrahedrons, two modifications of GaPO4 exist with different optical rotation (left and right).
Sources
GaPO4 does not occur in nature; thus it must be grown synthetically. Presently, only one company in Austria produces these crystals commercially.
History and technical importance
Pressure sensors based on quartz have to be cooled with water for applications at
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https://en.wikipedia.org/wiki/Gene%20orders
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Gene orders are the permutation of genome arrangement. A fair amount of research has been done trying to determine whether gene orders evolve according to a molecular clock (molecular clock hypothesis) or in jumps (punctuated equilibrium).
Some research on gene orders in animals' mitochondrial genomes reveal that the mutation rate of gene orders is not a constant in some degrees.
References
Genetics
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https://en.wikipedia.org/wiki/Studen%C3%A1%2C%20Slovakia
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Studená () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/S%C3%BAtor
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Sútor () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0imonovce
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Šimonovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0irkovce
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Širkovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0panie%20Pole
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Španie Pole () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
References
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Norina%20Matchabelli
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Princess Norina Matchabelli (born Eleanora Erna Cecilia Gilli; 3 March 1880 – 15 June 1957) was co-founder of the perfume company Prince Matchabelli, a stage and screen actress, publisher, and a disciple of Indian spiritual teacher Meher Baba. Her stage name was Maria Carmi.
Acting career as Maria Carmi
Gilli was born in Florence, Italy, the daughter of confectioner Luigi Gilli, originally from Samedan, and his wife Emma Troll from Winterthur. She was the youngest of five children and spent her youth in Florence and Fiesole.
She began her stage career at Max Reinhardt's acting school at the Deutsches Theater and belonged to his company from 1907 to 1909. Under the stage name Maria Carmi, she played in Italian and German theater and in silent films.
Her most notable performance was as the Madonna in the original spectacle-pantomime play The Miracle written by Karl Vollmöller whom she married in 1904. The play was originally produced in Germany. It opened in London on 23 December 1911 at the Olympia Arena. On 23 December 1923 it was revived in New York City on Broadway, then went on a tour of Detroit, Milwaukee and Dallas.
In the New York version she alternated nightly with Lady Diana Manners, another international beauty of the period. In all Norina gave over 1,000 performances of the play.
Princess and perfume
After divorcing Vollmöller, Norina married Georges V. Matchabelli, the Georgian prince and diplomat, in Stockholm, Sweden, in 1917. Georges was the Georgian ambass
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https://en.wikipedia.org/wiki/Specially%20Protected%20Areas%20of%20Mediterranean%20Importance
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Specially Protected Areas of Mediterranean Importance (SPAMI) are sites "of importance for conserving the components of biological diversity in the Mediterranean; contain ecosystems specific to the Mediterranean area or the habitats of endangered species; are of special interest at the scientific, aesthetic, cultural or educational levels".
Context
The Protocols are part of a wider international effort aimed at protecting the Mediterranean Sea, i.e. the MAP, a programme co-ordinated by UNEP the origins of which go back to the Barcelona Convention of 1976 for Protection against Pollution in the Mediterranean. Similar plans exist for other regional seas around the world. Treaties and protocols providing for the specific protection of certain sites in these regions have also been adopted.
The SPAMI List
The 1995 Protocol provides for the establishment of a List of SPAMI. SPAMI may be created both within areas of national jurisdiction and on the high seas. The decision to include an area in the SPAMI List is taken by consensus by the contracting parties during their periodic meetings. The protection and management measures applying in the SPAMI are those prescribed by the States proposing them but all parties are to comply with such measures. The Ligurian Sea Cetacean Sanctuary is the largest of the SPAMI sites.
The RAC-SPA
The Regional Activity Centre for Specially Protected Areas (RAC/SPA) was established by the Contracting Parties to the Barcelona Convention in order to
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https://en.wikipedia.org/wiki/Soy%20molasses
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Soy molasses is brown viscous syrup with a typical bittersweet flavor. A by-product of aqueous alcohol soy protein concentrate production, soy molasses is a concentrated, desolventized, aqueous alcohol extract of defatted soybean flakes.
The term "soy molasses" was coined by Daniel Chajuss, the founder of Hayes Ashdod Ltd., which first commercially produced and marketed soy molasses in the early 1960s. The name was intended to distinguish the product from “soybean whey” or “condensed soybean solubles”, the by-products available at the time from soy protein isolate and acid washed soy protein concentrate production.
Manufacture
The alcohols are removed from the liquid extract by evaporation and the distillation residue is an aqueous solution of the sugars and other soy solubles. This solution is concentrated to viscous honey-like consistency to yield soy molasses.
Composition
Typically, soy molasses contains 50% total soluble solids. These solids consist of carbohydrates (60%), proteins and other nitrogenous substances (10%), minerals (10%), fats and lipoids (20%). The major constituents of soy molasses are sugars that include oligosaccharides (stachyose and raffinose), disaccharides (sucrose) and minor amounts of monosaccharides (fructose and glucose). Minor constituents include saponins, protein, lipid, minerals (ash), isoflavones, and other organic materials.
Use
Soy molasses is used as a feed ingredient in mixed feeds as pelleting aid, added to soybean meal (e.g. by sp
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https://en.wikipedia.org/wiki/Crystal%20Jade
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Crystal Jade (Chinese: 翡翠餐饮集团), owned by Crystal Jade Culinary Concept Holdings, is a Singapore-based Chinese restaurant chain.
See also
List of Chinese restaurants
References
The Straits Times, "Clone Wars", 2006-10-15 The print article discussed competition between Crystal Jade and Imperial Treasure as well as reviewed both restaurants.
External links
Official website
Restaurant chains in Singapore
Chinese restaurants outside China
Restaurants established in 1991
1991 establishments in Singapore
Singaporean brands
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https://en.wikipedia.org/wiki/Monoacylglycerol%20lipase
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Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.
Function
Monoacylglycerol lipase catalyzes a reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids:
hydrolyses glycerol monoesters of long-chain fatty acids
It functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). It converts monoacylglycerols to the free fatty acid and glycerol. The contribution of MAGL to total brain 2-AG hydrolysis activity has been estimated to be ~85% (ABHD6 and ABHD12 are responsible for ~4% and ~9%, respectively, of the remainder), and this in vitro estimate has been confirmed in vivo by the selective MAGL inhibitor JZL184. Chronic inactivation of MAGL results in massive (>10-fold) elevations of brain 2-
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https://en.wikipedia.org/wiki/Haplogroup%20L0
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Haplogroup L0 is a human mitochondrial DNA (mtDNA) haplogroup.
Origin
L0 is one of two branches from the most recent common ancestor (MRCA) for the shared human maternal lineage. The haplogroup consists of five main branches (L0a, L0b, L0d, L0f, L0k). Four of them were originally classified into L1 subclades, L1a, L1d, L1f and L1k.
In 2014, ancient DNA analysis of a 2,330 year old male forager's skeleton in Southern Africa found that the specimen belonged to the L0d2c1c mtDNA subclade. This maternal haplogroup is today most closely associated with the Ju, a subgroup of the indigenous San people, which points to population continuity in the region. In 2016, a Late Iron Age desiccated mummy from the Tuli region in northern Botswana was also found to belong to haplogroup L0.
Distribution
L0 is found most commonly in Sub-Saharan Africa. It reaches its highest frequency in the Khoisan people at 73% on average. Some of the highest frequencies are: Namibia (!Xun) 79%, South Africa (Khwe/!Xun) 83%, and Botswana (!Kung) 100%.
Haplogroup L0d is found among Khoisan groups of Southern Africa closer to the Khoid side with (following L0k) being more Sanid but is largely restricted to the Khoisan as a whole. L0d is also commonly found in sections of the Coloured population of South Africa and frequencies range from 60% to 71%. This illustrates the massive maternal contribution of Khoisan people to sections of the Coloured population of South Africa.
Haplogroups L0k is the second mo
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https://en.wikipedia.org/wiki/Diacylglycerol%20lipase
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Diacylglycerol lipase, also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol:diacylglycerol + H2O ⇌ monoacylglycerol + free fatty acidDAGL has been studied in multiple domains of life, including bacteria, fungi, plants, insects, and mammals. By searching with BLAST for the previously sequenced microorganism DAGL, Bisogno et al discovered two distinct mammalian isoforms, designated DAGLα () and DAGLβ (). Most animal DAGL enzymes cluster into the DAGLα and DAGLβ isoforms.
Mammalian DAGL is a crucial enzyme in the biosynthesis of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in tissues. The endocannabinoid system has been identified to have considerable involvement in the regulation of homeostasis and disease. As a result, much effort has been made toward investigating the mechanisms of action and the therapeutic potential of the system's receptors, endogenous ligands, and enzymes like DAGLα and DAGLβ.
Structure
While both DAGLα and DAGLβ are extensively homologous (sharing 34% of their sequence), DAGLα (1042 amino acids) is much larger than DAGLβ (672 amino acids) due to the presence of a sizeable C-terminal tail in the former.
Both DAGLα and DAGLβ have a transmembrane domain at the N-terminal that starts with a conserved 19 amino acid cytoplasmic sequence followed by four transmembrane helices. These transmembrane helices are connected by three short loops, o
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https://en.wikipedia.org/wiki/RATS
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RATS may refer to:
RATS (software), Regression Analysis of Time Series, a statistical package
Robot Astronomy Talk Show, an animated educational series that's part of NASA's IRrelevant Astronomy vodcast
Regional Anti-Terrorist Structure, the Shanghai Cooperation Organisation's anti-terrorism branch
See also
Rat (disambiguation)
The Rat (disambiguation)
The Rats (disambiguation)
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https://en.wikipedia.org/wiki/United%20States%20Consumer%20Price%20Index
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The United States Consumer Price Index (CPI) is a set of various consumer price indices published monthly by the U.S. Bureau of Labor Statistics (BLS). The most commonly used are the CPI-U and the CPI-W, though many alternative versions exist. The CPI-U is the most popular measure of consumer inflation in the United States (though Social Security benefit payments are indexed to the CPI-W).
Methodology
Item coverage
The CPI measures the monthly price change of a basket of discretionary consumption goods whose price is borne by the consumer. There are eight major categories of items that are included in the CPI coverage; each includes both goods and services:
Food and beverages
Housing
Apparel
Transportation
Medical care
Recreation
Education and communication
Other goods and services
In line with this framework, the CPI excludes items such as life insurance, investment securities, financing costs, house prices (though the value of owned housing, distinct from a house price, is included in the CPI), as these are considered to be investment items, not consumption. Also excluded are income and property taxes, employer-provided benefits, and the portion of healthcare costs paid by the government or insurance plans, since these prices are not borne directly by consumers. However, sales and excise taxes, out-of-pocket healthcare costs, and health insurance premiums paid by the consumer (including Medicare Part B) are all included in the CPI, because consumers directly be
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https://en.wikipedia.org/wiki/MDIA
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MDIA may refer to:
mDia, or mammalian diaphanous, a Rho effector protein involved in cytoskeletal polymerisation (see DIAPH1)
Men's Division of Intercollegiate Associates, now called the Men's Collegiate Lacrosse Association
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https://en.wikipedia.org/wiki/Amel%20%28disambiguation%29
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Amel is a municipality and village in the German-speaking Community of Belgium.
Amel may also refer to:
Amel (name)
Amelogenin (AMELY and AMELX), sex determining DNA chromosomal markers
Amel (river), a Belgian river also known as Amblève
Amel (UAV), a drone
Amel Yachts
Amel Association International, a Lebanese non-profit non-governmental organization
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https://en.wikipedia.org/wiki/Neanderthal%20genome%20project
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The Neanderthal genome project is an effort of a group of scientists to sequence the Neanderthal genome, founded in July 2006.
It was initiated by 454 Life Sciences, a biotechnology company based in Branford, Connecticut in the United States and is coordinated by the Max Planck Institute for Evolutionary Anthropology in Germany. In May 2010 the project published their initial draft of the Neanderthal genome (Vi33.16, Vi33.25, Vi33.26) based on the analysis of four billion base pairs of Neanderthal DNA. The study determined that some mixture of genes occurred between Neanderthals and anatomically modern humans and presented evidence that elements of their genome remain in modern humans outside Africa.
In December 2013, a high coverage genome of a Neanderthal was reported for the first time. DNA was extracted from a toe fragment from a female Neanderthal researchers have dubbed the "Altai Neandertal". It was found in Denisova Cave in the Altai Mountains of Siberia and is estimated to be 50,000 years old.
Findings
The researchers recovered ancient DNA of Neanderthals by extracting the DNA from the femur bones of three 38,000 year-old female Neanderthal specimens from Vindija Cave, Croatia, and other bones found in Spain, Russia, and Germany. Only about half a gram of the bone samples (or 21 samples each 50–100 mg) was required for the sequencing, but the project faced many difficulties, including the contamination of the samples by the bacteria that had colonized the Neander
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https://en.wikipedia.org/wiki/Crystal%20Heights%2C%20Nova%20Scotia
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Crystal Heights is a neighborhood in the north end of the Dartmouth area in Nova Scotia's Halifax Regional Municipality.
Part of the larger neighbourhood of Albro Lake, Crystal Heights is a development comprising high-density apartment buildings. It is adjacent to Highfield Park, a similar development dating to the 1970s.
Communities in Halifax, Nova Scotia
Dartmouth, Nova Scotia
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https://en.wikipedia.org/wiki/DNA%20adenine%20methylase
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DNA adenine methylase, (Dam) (also site-specific DNA-methyltransferase (adenine-specific), , modification methylase, restriction-modification system) is an enzyme that adds a methyl group to the adenine of the sequence 5'-GATC-3' in newly synthesized DNA. Immediately after DNA synthesis, the daughter strand remains unmethylated for a short time. It is an orphan methyltransferase that is not part of a restriction-modification system and regulates gene expression. This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
This is a large group of enzymes unique to prokaryotes and bacteriophages.
The E. coli DNA adenine methyltransferase enzyme (Dam), is widely used for the chromatin profiling technique DamID, in which the Dam is fused to a DNA-binding protein of interest and expressed as a transgene in a genetically tractable model organism to identify protein binding sites.
Role in mismatch repair of DNA
When DNA polymerase makes an error resulting in a mismatched base-pair or a small insertion or deletion during DNA synthesis, the cell will repair the DNA by a pathway called mismatch repair. However, the cell must be able to differentiate between the template strand and the newly synthesized strand. In some bacteria, DNA strands are methylated by Dam methylase, and therefore, immediately after replication, the DNA will be hemimethylated. A repair enzyme, MutS, binds to mismatches in
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https://en.wikipedia.org/wiki/Basic%20pitch%20count%20estimator
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In baseball statistics, the basic pitch count estimator is a statistic used to estimate the number of pitches thrown by a pitcher where there is no pitch count data available. The formula was first derived by Tom Tango. The formula is , where PA refers to the number of plate appearances against the pitcher, SO to strikeouts and BB to base on balls.
See also
Pitch count
Batters faced by pitcher
References
Pitching statistics
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https://en.wikipedia.org/wiki/Ran%20%28protein%29
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Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.
Ran is a small G protein that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein has also been implicated in the control of DNA synthesis and cell cycle progression, as mutations in Ran have been found to disrupt DNA synthesis.
Function
Ran cycle
Ran exists in the cell in two nucleotide-bound forms: GDP-bound and GTP-bound. RanGDP is converted into RanGTP through the action of RCC1, the nucleotide exchange factor for Ran. RCC1 is also known as RanGEF (Ran Guanine nucleotide Exchange Factor). Ran's intrinsic GTPase-activity is activated through interaction with Ran GTPase activating protein (RanGAP), facilitated by complex formation with Ran-binding protein (RanBP). GTPase-activation leads to the conversion of RanGTP to RanGDP, thus closing the Ran cycle.
Ran can diffuse freely within the cell, but because RCC1 and RanGAP are located in different places in the cell, the concentration of RanGTP and RanGDP differs locally as well, creating concentration gradients that act as signals for other cellular processes. RCC1 is bound to chromatin and therefore located inside the nucleus. RanGAP is cytoplasmic in yeast
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https://en.wikipedia.org/wiki/Antarctic%20tern
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The Antarctic tern (Sterna vittata) is a seabird in the family Laridae. It ranges throughout the southern oceans and is found on small islands around Antarctica as well as on the shores of the mainland. Its diet consists primarily of small fish and crustaceans. It is very similar in appearance to the closely related Arctic tern, but it is stockier, and it is in its breeding plumage in the southern summer, when the Arctic tern has shed old feathers to get its non-breeding plumage. The Antarctic tern does not migrate like the Arctic tern does, but it can still be found on a very large range. This tern species is actually more closely related to the South American tern.
Gulls, skuas and jaegers are the primary predators of the bird's eggs and young.
The Antarctic tern can be further divided into six subspecies. The total global population of this bird is around 140,000 individuals.
Taxonomy
The Antarctic tern was formally described in 1789 by the German naturalist Johann Friedrich Gmelin in his revised and expanded edition of Carl Linnaeus's Systema Naturae. He placed it with the other terns in the genus Sterna and coined the binomial name Sterna vittata. Gmelin based his description on the "wreathed tern" that had been described in 1785 by the English ornithologist John Latham in his book A General Synopsis of Birds . Latham had been provided with a specimen by the naturalist Joseph Banks. Latham mistakenly believed it had come from Christmas Island in the Indian Ocean but i
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https://en.wikipedia.org/wiki/Rural%20Municipality%20of%20Piney
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The Rural Municipality of Piney is a rural municipality (RM) in southeastern Manitoba, Canada, along the border with Minnesota in the United States.
Geography
According to Statistics Canada, the municipality has a land area of 2,433.77 km2. It is bordered by the rural municipalities of Stuartburn, La Broquerie, and Reynolds, as well as the Buffalo Point 36 Indian reserve and an unorganized part of the province (Division No. 1, Unorganized, Manitoba).
The municipality borders Roseau County in the U.S. state of Minnesota. There are three international border crossings in Piney, the most of any Manitoba municipality: Pinecreek–Piney, Roseau–South Junction, and Warroad–Sprague Border Crossings.
A minority but large part of Sandilands Provincial Forest is located here, as is a small part of Northwest Angle Provincial Forest. Also, Cat Hills Provincial Forest and Wampum Provincial Forest are both entirely located here, but these two forests are relatively tiny in size.
Communities
Badger
Carrick
Menisino
Middlebro
Piney
St. Labre
Sandilands
South Junction
Sprague
Vassar
Wampum
Woodridge
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Piney had a population of 1,843 living in 804 of its 1,172 total private dwellings, a change of from its 2016 population of 1,726. With a land area of , it had a population density of in 2021.
In 2001, there were 690 housing units at an average density of 0.28/km2. 2.4% of the people in the municipal
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https://en.wikipedia.org/wiki/Cadence%20SKILL
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SKILL is a Lisp dialect used as a scripting language and PCell (parameterized cells) description language used in many electronic design automation (EDA) software suites by Cadence Design Systems. It was originally put forth in an Institute of Electrical and Electronics Engineers (IEEE) paper in 1990.
History
SKILL was originally based on a flavor of Lisp called Franz Lisp created at University of California, Berkeley by the students of Professor Richard J. Fateman. SKILL is not an acronym; it is a name. For trademark reasons Cadence prefers it be capitalized.
Franz Lisp and all other flavors of LISP were eventually superseded by an ANSI standard for Common Lisp. Historically, SKILL was known as IL. SKILL was a library of IL functions. The name was originally an initialism for Silicon Compiler Interface Language (SCIL), pronounced "SKIL", which then morphed into "SKILL", a plain English word that was easier for everyone to remember.
"IL" was only Interface Language. Although SKILL was used initially to describe the application programming interface (API) rather than the language, the snappier name stuck. The name IL remains a common file extension used for SKILL code designating that the code contained in the file has lisp-2 semantics. Another possible file extension is , designating that the content has lisp-1 semantics.
References
Academic:
G. Wood and H-F S. Law, "SKILL - An Interactive Procedural Design Environment," Proceedings of Custom Integrated Circuits Confe
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https://en.wikipedia.org/wiki/ZMap
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ZMap may refer to:
ZMap (software), a free and open-source network scanner
ZMap, an algorithm for storing cutter location values
ZMapp, an experimental treatment for Ebola virus disease
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https://en.wikipedia.org/wiki/Jimmy%20Carter%20%28footballer%29
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James William Charles Carter (born 9 November 1965) is an English former footballer. Playing as a winger, Carter featured for Crystal Palace, Queens Park Rangers, Millwall, Liverpool, Arsenal, Oxford United and Portsmouth throughout his career.
Early life
Carter was born on 9 November 1965, of mixed ancestry. His British surname came from a 17th-century ancestor who moved to India and married an Indian woman. His father Maurice originated from Kanpur in India, and was brought up in Lucknow. After being orphaned at 14, Maurice joined the merchant navy, came to England, and married Jimmy's English mother. When they divorced, Maurice brought up Jimmy and his brother 'as Indian kids'. Maurice (who died in January 2009) encouraged Jimmy to make it as a footballer, waking him early on frosty mornings to train.
Career
Carter began his professional career aged 14 at Crystal Palace, who released him when 19, and then had a brief spell with Queens Park Rangers, but failed to make a league appearance for either club.
Millwall bought Carter from QPR in 1987 for £15,000 and gave him his Football League debut in a 0–0 draw with Oldham at The Den in the Second Division. He quickly established himself in the first team and was an integral part of the team which gained promotion to the top flight in 1987–88, the first time ever in Millwall's 100-year history. In December of that season, Sheffield United defender Chris Wilder was sent off for a crude tackle on Carter.
Carter was part of
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https://en.wikipedia.org/wiki/List%20of%20misnamed%20theorems
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This is a list of misnamed theorems in mathematics. It includes theorems (and lemmas, corollaries, conjectures, laws, and perhaps even the odd object) that are well known in mathematics, but which are not named for the originator. That is, these items on this list illustrate Stigler's law of eponymy (which is not, of course, due to Stephen Stigler, who credits Robert K Merton).
== Applied mathematics ==
Benford's law. This was first stated in 1881 by Simon Newcomb, and rediscovered in 1938 by Frank Benford. The first rigorous formulation and proof seems to be due to Ted Hill in 1988.; see also the contribution by Persi Diaconis.
Bertrand's ballot theorem. This result concerning the probability that the winner of an election was ahead at each step of ballot counting was first published by W. A. Whitworth in 1878, but named after Joseph Louis François Bertrand who rediscovered it in 1887. A common proof uses André's reflection method, though the proof by Désiré André did not use any reflections.
Algebra
Burnside's lemma. This was stated and proved without attribution in Burnside's 1897 textbook, but it had previously been discussed by Augustin Cauchy, in 1845, and by Georg Frobenius in 1887.
Cayley–Hamilton theorem. The theorem was first proved in the easy special case of 2×2 matrices by Cayley, and later for the case of 4×4 matrices by Hamilton. But it was only proved in general by Frobenius in 1878.
Hölder's inequality. This inequality was first established by Leonard Jam
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https://en.wikipedia.org/wiki/CYP27A1
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CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the mitochondria. It is most prominently involved in the biosynthesis of bile acids.
Function
CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3β-hydroxy-5-cholestenoic acid.
While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
Clinical significance
Mutations in CYP27A1 are associated with cerebrotendineous xanthomatosis, a rare lipid storage disease.
Inhibitors of CYP27A1 may be effective as adjuvants in the treatment of ER-positive breast cancer due to inhibition of the production of 27-hydroxycholesterol (which has estrogenic actions and stimulates the growth of ER-positive breast cancer cells). Some marketed drugs that have been identified as CYP27A1 inhibitors include anastrozole, fadrozole, bicalutamide, dexmedetomidine, r
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https://en.wikipedia.org/wiki/Erythropoietic%20porphyria
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Erythropoietic porphyria is a type of porphyria associated with erythropoietic cells. In erythropoietic porphyrias, the enzyme deficiency occurs in the red blood cells.
Types
There are three types:
Presentation
X-linked dominant erythropoietic protoporphyria is a relatively mild version of porphyria with the predominant symptom being extreme photosensitivity causing severe itching and burning sensation of the skin due to the buildup of protoporphyrin IX. One possible treatment was discovered when treating an individual with supplemental iron for a gastric ulcer. Levels of free protoporphyrin decreased significantly as there was iron available for the FECH to produce heme. Levels of zinc-protoporphyrin, however did not decrease.
Cause
X-linked sideroblastic anemia or "X-linked dominant erythropoietic protoporphyria", associated with ALAS2 (aminolevulinic acid synthase), has also been described. X-linked dominant erythropoietic protoporphyria (XDEPP) is caused by a gain of function mutation in the ALAS2 (5-aminolevulinate synthase) gene; that gene encodes the very first enzyme in the heme biosynthetic pathway. The mutation is caused by a frameshift mutation caused by one of two deletions in the ALAS2 exon 11, either c. 1706-1709 delAGTG or c. 1699-1700 delAT. This alters the 19th and 20th residues of the C-terminal domain thereby altering the secondary structure of the enzyme. The delAT mutation only occurred in one family studied whereas the delAGTG mutation occurred
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https://en.wikipedia.org/wiki/Diffusion%20%28acoustics%29
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Diffusion, in architectural acoustics, is the spreading of sound energy evenly in a given environment. A perfectly diffusive sound space is one in which the reverberation time is the same at any listening position.
Most interior spaces are non-diffusive; the reverberation time is considerably different around the room. At low frequencies, they suffer from prominent resonances called room modes.
Diffusor
Diffusors (or diffusers) are used to treat sound aberrations, such as echoes, in rooms. They are an excellent alternative or complement to sound absorption because they do not remove sound energy, but can be used to effectively reduce distinct echoes and reflections while still leaving a live sounding space. Compared to a reflective surface, which will cause most of the energy to be reflected off at an angle equal to the angle of incidence, a diffusor will cause the sound energy to be radiated in many directions, hence leading to a more diffusive acoustic space. It is also important that a diffusor spreads reflections in time as well as spatially. Diffusors can aid sound diffusion, but this is not why they are used in many cases; they are more often used to remove coloration and echoes.
Diffusors come in many shapes and materials. The birth of modern diffusors was marked by Manfred R. Schroeders' invention of number-theoretic diffusors in the 1970s.
Maximum length sequence diffusors
Maximum length sequence based diffusors are made of strips of material with two different
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https://en.wikipedia.org/wiki/Ramponio%20Verna
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Ramponio Verna was a comune (municipality) in the Province of Como in the Italian region Lombardy, located about north of Milan and about north of Como. It's a frazione of Alta Valle Intelvi since 2017 and as of 31 December 2004, it had a population of 420 and an area of .
References
Cities and towns in Lombardy
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https://en.wikipedia.org/wiki/Arylsulfatase%20B
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Arylsulfatase B (N-acetylgalactosamine-4-sulfatase, chondroitinsulfatase, chondroitinase, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, ) is an enzyme associated with mucopolysaccharidosis VI (Maroteaux–Lamy syndrome).
Arylsulfatase B is among a group of arylsulfatase enzymes present in the lysosomes of the liver, pancreas, and kidneys of animals. The purpose of the enzyme is to hydrolyze sulfates in the body. ARSB does this by breaking down glycosaminoglycans (GAGs), which are large sugar molecules in the body. ARSB targets two GAGs in particular: dermatan sulfate and chondroitin sulfate.
Over 130 mutations to ARSB have been found, each leading to a deficiency in the body. In most cases, the mutation occurs on a single nucleotide in the sequence. An arylsulfatase B deficiency can lead to an accumulation of GAGs in lysosomes, which in turn can lead to mucopolysaccharidosis VI.
Used as a pharmaceutical drug, the enzyme is known under the International Nonproprietary Name galsulfase and is sold under the brand name Naglazyme. Galsulfase was approved for medical use in the United States in May 2005 and in European Union in January 2006. Galsulfase is indicated for long-term enzyme-replacement therapy in people with a confirmed diagnosis of mucopolysaccharidosis VI (MPS VI; N-acetylgalactosamine-4-sulfatase deficiency; Maroteaux-Lamy syndrome).
Structure
The primary structure of Escherichia coli arylsulfatase B contains a primary sequenc
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https://en.wikipedia.org/wiki/Maroteaux%E2%80%93Lamy%20syndrome
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Maroteaux–Lamy syndrome, or Mucopolysaccharidosis Type VI (MPS-VI), is an inherited disease caused by a deficiency in the enzyme arylsulfatase B (ARSB). ASRB is responsible for the breakdown of large sugar molecules called glycosaminoglycans (GAGs, also known as mucopolysaccharides). In particular, ARSB breaks down dermatan sulfate and chondroitin sulfate. Because people with MPS-VI lack the ability to break down these GAGs, these chemicals build up in the lysosomes of cells. MPS-VI is therefore a type of lysosomal storage disease.
Signs and symptoms
Unlike other MPS diseases, children with Maroteaux–Lamy syndrome usually have normal intelligence. They share many of the physical symptoms found in Hurler syndrome. Maroteaux–Lamy syndrome has a variable spectrum of severe symptoms. Neurological complications include clouded corneas, deafness, thickening of the dura (the membrane that surrounds and protects the brain and spinal cord), and pain caused by compressed or traumatized nerves and nerve roots.
At birth, people with Maroteaux-Lamy syndrome typically do not display any signs or symptoms. Signs are revealed early in the affected child's life, with one of the first symptoms often being a significantly prolonged age of learning how to walk. Growth begins normally, but children usually stop growing by age 8. By age 10, children often develop a shortened trunk, crouched stance, and restricted joint movement. In more severe cases, children also develop a protruding abdomen a
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