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https://en.wikipedia.org/wiki/Pocking%20Solar%20Park | The Pocking Solar Park is a photovoltaic power station in Pocking, Lower Bavaria, Germany. It has installed capacity of 10 megawatts. Construction and assembly of the power plant begun in August 2005 and was completed in March 2006.
The power plant is located on on the former military training area. It has 57,912 modules.
See also
Energy policy of the European Union
Renewable energy commercialization
Renewable energy in Germany
References
Photovoltaic power stations in Germany
Passau (district) |
https://en.wikipedia.org/wiki/Pac-12%20Conference%20football%20statistics | Historical statistics for football in the Pacific Coast Conference (PCC, 1915-1959), Athletic Association of Western Universities (AAWU, 1959–68), Pacific-8 (1968–78), Pacific-10 (1978-2011), and Pac-12 Conference (2011–present).
Season finishes
References
statistics |
https://en.wikipedia.org/wiki/Toyota%20LiteAce | The Toyota LiteAce and TownAce are a line of light commercial and derivative passenger vans produced by the Japanese car manufacturer Toyota. These vehicles originally utilized the cab-over-engine configuration, although since 1996 a semi-cab-over arrangement has featured instead. The LiteAce launched in 1970 as light-duty truck, with commercial and van/wagon body variants added in 1971. In 1976, Toyota released the larger TownAce van/wagon that derived from the LiteAce; a TownAce truck arrived later in 1978. Between 1982 and 1992, the series accommodated the MasterAce Surf—an upscale TownAce passenger wagon.
The two model lines existed separately until 1982 when TownAce trucks became rebadged LiteAce trucks—then in 1992 LiteAce vans became rebranded TownAce vans—thus unifying the once separate vehicle lines. In Japan, the LiteAce retailed at Toyota Auto Store dealerships, with the TownAce sold at Toyota Corolla Store dealerships. The LiteAce and TownAce have been commonly exported to Africa, Asia and Australia. Over the years, select LiteAce/TownAce models have also been available with Daihatsu Delta badging in Japan. Originally sold as the Delta 750 based on the LiteAce truck, later versions have been badged Delta Wide and based on the TownAce van. For the final Delta retailed between 1996 and 2001, the "Wide" suffix disappeared.
The LiteAce followed the introduction of the more compact MiniAce and larger HiAce in 1967, acting as an intermediacy between these two models i |
https://en.wikipedia.org/wiki/Herbimycin | Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
It was originally found by its herbicidal activity, and thus named. The most recent herbimycins to be discovered, herbimycins D-F, were isolated from a Streptomyces isolated from thermal vents associated with the Ruth Mullins coal fire in Appalachian Kentucky.
Synonyms
Antibiotic Tan 420F
Herbimycin A
Biological activity
Herbimycin induces the degradation of proteins that are need to be mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via Hsp90.
See also
Geldanamycin
Satoshi Ōmura
References
External links
Herbimycin A from Center for Pharmaceutical Research and Innovation
Antibiotics
1,4-Benzoquinones
Carbamates
Lactams
Ethers
Ansamycins |
https://en.wikipedia.org/wiki/Frequency%20synthesizer | A frequency synthesizer is an electronic circuit that generates a range of frequencies from a single reference frequency. Frequency synthesizers are used in many modern devices such as radio receivers, televisions, mobile telephones, radiotelephones, walkie-talkies, CB radios, cable television converter boxes, satellite receivers, and GPS systems. A frequency synthesizer may use the techniques of frequency multiplication, frequency division, direct digital synthesis, frequency mixing, and phase-locked loops to generate its frequencies. The stability and accuracy of the frequency synthesizer's output are related to the stability and accuracy of its reference frequency input. Consequently, synthesizers use stable and accurate reference frequencies, such as those provided by a crystal oscillator.
Types
Three types of synthesizer can be distinguished. The first and second type are routinely found as stand-alone architecture: direct analog synthesis (also called a mix-filter-divide architecture as found in the 1960s HP 5100A) and the more modern direct digital synthesizer (DDS) (table-look-up). The third type are routinely used as communication system IC building-blocks: indirect digital (PLL) synthesizers including integer-N and fractional-N. The recently emerged TAF-DPS is also a direct approach. It directly constructs the waveform of each pulse in the clock pulse train.
Digiphase synthesizer
It is in some ways similar to a DDS, but it has architectural differences. One of its |
https://en.wikipedia.org/wiki/The%20Judgment%20of%20Paris%20%28opera%29 | The Judgment of Paris is an operatic libretto written by William Congreve. It was set by four British Baroque composers – John Weldon, John Eccles, Daniel Purcell and Gottfried Finger – as part of a music competition held in 1700-1701. Thomas Arne later composed a score to the libretto in 1742.
Roles
Mercury, messenger of the gods
Paris, a shepherd
Juno, goddess of marriage. This role was taken by the soprano Mary Hodgson.
Pallas, goddess of war
Venus, goddess of love
Chorus
Synopsis
Setting: Mount Ida
The god Mercury descends from the sky with the golden apple of Discord and asks the shepherd Paris to award it to whichever of the three goddesses – Juno, Pallas and Venus – he finds most worthy. Juno offers him worldly power, Pallas victory in war, and Venus the most beautiful woman in the world. Paris gives the golden apple to Venus.
The "Musick Prize"
A group of English nobles headed by Lord Halifax had become interested in promoting all-sung English opera (most English operas of the day took the form of semi-operas mixing music and spoken drama). In an announcement in the London Gazette of 18 March 1700 they offered a "Musick Prize" for the best setting of Congreve's short libretto. First prize was 100 guineas, second 50, third 30, and fourth 20.
Four composers entered the competition: John Weldon, John Eccles, Daniel Purcell and Gottfried Finger. Their works were performed individually during the spring of 1701, then staged together in a grand final at the Dorset Gar |
https://en.wikipedia.org/wiki/CD5%20%28protein%29 | CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. The expression of this receptor in human B cells has been a controversial topic and to date there is no consensus regarding the role of this receptor as a marker of human B cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.
In humans, the gene is located on the long arm of chromosome 11. There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface of other cells. CD5 includes a scavenger receptor cysteine-rich protein domain.
T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.
Immunohistochemistry
CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chro |
https://en.wikipedia.org/wiki/PDIA3 | Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme. This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
Structure
The PDIA3 protein consists of four thioredoxin-like domains: a, b, b′, and a′. The a and a′ domains have Cys-Gly-His-Cys active site motifs (C57-G58-H59-C60 and C406-G407-H408-C409) and are catalytically active. The bb′ domains contain a CNX binding site, which is composed of positively charged, highly conserved residues (K214, K274, and R282) that interact with the negatively charged residues of the CNX P domain. The b′ domain comprises the majority of the binding site, but the β4-β5 loop of the b domain provides additional contact (K214) to strengthen the interaction. A transient disulfide bond forms between the N-terminal cysteine in the catalytic motif and a substrate, but in a step called "escape pathway", the bond is disrupted as the C-terminal cysteine attacks the N-terminal cysteine to release the substrate.
Function
The PDIA3 protein is a thiol oxidoreductase that has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide loading complex, |
https://en.wikipedia.org/wiki/Cylindrospermopsin | Cylindrospermopsin (abbreviated to CYN, or CYL) is a cyanotoxin produced by a variety of freshwater cyanobacteria. CYN is a polycyclic uracil derivative containing guanidino and sulfate groups. It is also zwitterionic, making it highly water soluble. CYN is toxic to liver and kidney tissue and is thought to inhibit protein synthesis and to covalently modify DNA and/or RNA. It is not known whether cylindrospermopsin is a carcinogen, but it appears to have no tumour initiating activity in mice.
CYN was first discovered after an outbreak of a mystery disease on Palm Island, Queensland, Australia. The outbreak was traced back to a bloom of Cylindrospermopsis raciborskii in the local drinking water supply, and the toxin was subsequently identified. Analysis of the toxin led to a proposed chemical structure in 1992, which was revised after synthesis was achieved in 2000. Several analogues of CYN, both toxic and non-toxic, have been isolated or synthesised.
C. raciborskii has been observed mainly in tropical areas, however has also recently been discovered in temperate regions of Australia, North, South America, New Zealand and Europe. However, CYN-producing strain of C. raciborskii has not been identified in Europe, several other cyanobacteria species occurring across the continent are able to synthesize it.
Discovery
In 1979, 138 inhabitants of Palm Island, Queensland, Australia, were admitted to hospital, suffering various symptoms of gastroenteritis. All of these were childr |
https://en.wikipedia.org/wiki/PEAKS | PEAKS is a proteomics software program for tandem mass spectrometry designed for peptide sequencing, protein identification and quantification.
Description
PEAKS is commonly used for peptide identification (Protein ID) through de novo peptide sequencing assisted search engine database searching. PEAKS has also integrated PTM and mutation characterization through automatic peptide sequence tag based searching (SPIDER) and PTM Identification.
PEAKS provides a complete sequence for each peptide, confidence scores on individual amino acid assignments, simple reporting for high-throughput analysis, amongst other information.
The software has the ability to compare results of multiple search engines. PEAKS inChorus will cross check test results automatically with other protein ID search engines, like Sequest, OMSSA, X!Tandem and Mascot. This approach guards against false positive peptide assignments.
PEAKS Q is an add-on tool for protein quantification, supporting label (ICAT, iTRAQ, SILAC, TMT, 018, etc.) and label free techniques.
SPIDER is a sequence tag based search tool within PEAKS, which deals with the possible overlaps between the de novo sequencing errors and the homology mutations. It reconstructs the real peptide sequence by combining both the de novo sequence tag and the homolog, automatically and efficiently.
A collection of algorithms used within the PEAKS software have been adapted and configured into a specialized project, PEAKS AB, which has proven to be the |
https://en.wikipedia.org/wiki/Karamata%27s%20inequality | In mathematics, Karamata's inequality, named after Jovan Karamata, also known as the majorization inequality, is a theorem in elementary algebra for convex and concave real-valued functions, defined on an interval of the real line. It generalizes the discrete form of Jensen's inequality, and generalizes in turn to the concept of Schur-convex functions.
Statement of the inequality
Let be an interval of the real line and let denote a real-valued, convex function defined on . If and are numbers in such that majorizes , then
Here majorization means that and satisfies
and we have the inequalities
and the equality
If is a strictly convex function, then the inequality () holds with equality if and only if we have for all .
Remarks
If the convex function is non-decreasing, then the proof of () below and the discussion of equality in case of strict convexity shows that the equality () can be relaxed to
The inequality () is reversed if is concave, since in this case the function is convex.
Example
The finite form of Jensen's inequality is a special case of this result. Consider the real numbers and let
denote their arithmetic mean. Then majorizes the -tuple , since the arithmetic mean of the largest numbers of is at least as large as the arithmetic mean of all the numbers, for every . By Karamata's inequality () for the convex function ,
Dividing by gives Jensen's inequality. The sign is reversed if is concave.
Proof of the inequality
We may as |
https://en.wikipedia.org/wiki/Breast%20cyst | A breast cyst is a cyst, a fluid-filled sac, within the breast. One breast can have one or more cysts. They are often described as round or oval lumps with distinct edges. In texture, a breast cyst usually feels like a soft grape or a water-filled balloon, but sometimes a breast cyst feels firm.
Breast cysts can be painful and may be worrisome but are generally benign. They are most common in pre-menopausal women in their 30s or 40s. They usually disappear after menopause, but may persist or reappear when using hormone therapy. They are also common in adolescents.
Breast cysts can be part of fibrocystic disease. The pain and swelling is usually worse in the second half of the menstrual cycle or during pregnancy.
Treating breast cysts is usually not necessary unless they are painful or cause discomfort. In most cases, the discomfort they cause may be alleviated by draining the fluid from the cyst. The cysts form as a result of the growth of the milk glands. While some large cysts feel like lumps, most cysts cannot be identified during physical examinations.
Breast cysts are not to be confused with "milk cysts" (galactoceles), which usually appear during weaning.
Signs and symptoms
Signs and symptoms of breast cysts include:
A smooth, easily movable round or oval breast lump with distinct edges
Breast pain or tenderness in the area of the lump
Increased lump size and tenderness just before menstruation
Decreased lump size and resolution of other signs and symptoms afte |
https://en.wikipedia.org/wiki/Inferential | Inferential may refer to:
Inferential statistics; see statistical inference
Inference (logic)
Inferential mood (grammar)
Inferential programming
Inferential role semantics
Inferential theory of learning
Informal inferential reasoning
Simple non-inferential passage |
https://en.wikipedia.org/wiki/DU-Te%C5%A1%C5%A1up | DU–Teššup was the son of Aziru, of the 1350–1335 BC Amarna letters correspondence, and also the father of Aziru's successor, in Amurru (regional Syria). DU-Teššup's name refers to the Hurrian god of sky and storm, Teshub.
Aziru, and his father Abdi-Ashirta, were some of the major instigating forces (in the north) causing conflict with the Egyptian pharaoh, as cities ('city-states'), and regions were under constant threat and destruction in the northern, and western Canaan region (Lebanon, and southern Syria).
DU–Teššup is the presumed author of tablet-letter EA 169-(EA is for 'el Amarna') written to pharaoh, requesting Aziru's return from "forced"
consultation. DU–Teššup is not mentioned by name in the Amarna letters corpus.
History
Aziru was called to Egypt to explain his actions: bad, and good. Aziru wrote, as did his father Abdi-Ashirta, that he was protecting his regions. All the letters from both Aziru and Abdi Ashirta reflect: "the middle conflict", allegiance to pharaoh to the south (northeast Egypt), control and protection (calling 'to guard') the local cities (and their rulers), in northern Canaan, and personal aspirations of total control, and their personal aggrandizement. (This probably partially led to Abdi-Ashirta's death and removal from the scene, but since his son Aziru became the major player, Abdi-Ashirta's age can also be presumed.)
The Amarna letter–(169)
EA 169, title: "Aziru in Egypt"
With introduction damaged, etc.:
[...may all g]o well.
[In me] |
https://en.wikipedia.org/wiki/International%20Bone%20and%20Mineral%20Society | The International Bone and Mineral Society (IBMS) is a learned society in the field of bone and mineral metabolism, including osteoporosis and other diseases of bone.
History
IBMS started as the Parathyroid Conferences, a triennial event from 1960 to 1977.
In 1980, the group was incorporated in Quebec, Canada, under the name International Conferences on Calcium Regulating Hormones.
In 1995, the name was changed to IBMS and it was registered as a 501(c)(3) organization with headquarters in Washington, D.C., United States. IBMS holds annual scientific meetings and publishes the scientific journal Bone. IBMS also publishes IBMS BoneKEy, an open access website. BoneKEy Reports is the official online journal of the society.
See also
American Society for Bone and Mineral Research
Australian and New Zealand Bone and Mineral Society
External links
Bone
BoneKEy
Charities based in Washington, D.C.
International scientific organizations
Osteology
Health charities in the United States
Scientific organizations established in 1980
Medical and health organizations based in Washington, D.C. |
https://en.wikipedia.org/wiki/Rathowen | Rathowen () is a small village in County Westmeath, Ireland, on the N4 national primary route. Rathowen was designated as a census town by the Central Statistics Office for the first time in the 2016 census, at which time it had a population of 150 people.
The village is around 20 km northwest of Mullingar, 20 km southeast of Longford Town, and 100 km northwest of Dublin city centre.
Transport
Street and Rathowen railway station was opened on 1 August 1877 and finally closed on 17 June 1963.
See also
List of towns and villages in Ireland
References
Towns and villages in County Westmeath |
https://en.wikipedia.org/wiki/Martyn%20Amos | Martyn Amos is a Professor in the Department of Computer and Information Sciences at Northumbria University, working in natural computation, crowd simulation, DNA computing and synthetic biology. He was born in Hexham, Northumberland in 1971, brought up in Heddon-on-the-Wall, and attended school in Ponteland. He graduated with a degree in Computer Science from Coventry University in 1993 (which included an industrial placement working on the Ministry of Defence (United Kingdom) Corporate Headquarters Office Technology System), before earning a Ph.D. in DNA computing in 1997, from the University of Warwick. He then held a Leverhulme Trust Special Research Fellowship at the University of Liverpool, before taking up permanent academic appointments at the University of Liverpool (2000–2002), the University of Exeter (2002–2006), and Manchester Metropolitan University (2006-2018). He is a Fellow of the British Computer Society (FBCS), an active contributor to the Speakers for Schools education charity, and a Trustee of the Literary and Philosophical Society of Newcastle upon Tyne (the Lit & Phil).
Bibliography
— The first general text to cover the whole field.
— A popular science style introduction to the topic.
— A collection of "science into fiction" short stories, based on the themes of "unconventional computing" and artificial life, with accompanying afterwords written by consultant scientists.
References
Living people
British computer scientists
Alumni of Coventry Un |
https://en.wikipedia.org/wiki/Mudslide%20%28disambiguation%29 | Mudslide is a colloquial term for mudflow, the most rapid and fluid type of earth movement.
Mudslide may also refer to:
Mudslide (EP), a 2000 EP by The Bluetones
"Mudslide" (Batman: The Animated Series), a 1993 episode of Batman: The Animated Series
Mudslide, a variation of a White Russian cocktail
"Mudslide", a song by Guys All-Star Shoe Band from A Prairie Home Companion soundtrack |
https://en.wikipedia.org/wiki/TDO | TDO may refer to:
TDO connector, the telephone plug used in Austria.
The Delicious One, the mascot of the Wienerschnitzel restaurant
Tryptophan 2,3-dioxygenase, an enzyme in the metabolism of tryptophan
Tricho–dento–osseous syndrome, a rare genetic disorder affecting hair, teeth, and bones.
Teen Dance Ordinance, a law in Seattle enacted after morality crusades against all-ages nightclubs. |
https://en.wikipedia.org/wiki/Ly49 | Ly49 is a family of membrane C-type lectin-like receptors expressed mainly on NK cells but also on other immune cells (some CD8+ and CD3+ T lymphocytes, intestinal epithelial lymphocytes (IELs), NKT cells, uterine NK cells (uNK) cells, macrophages or dendritic cells). Their primary role is to bind MHC-I molecules to distinguish between self healthy cells and infected or altered cells. Ly49 family is coded by Klra gene cluster and include genes for both inhibitory and activating paired receptors, but most of them are inhibitory. Inhibitory Ly49 receptors play a role in the recognition of self cells and thus maintain self-tolerance and prevent autoimmunity by suppressing NK cell activation. On the other hand, activating receptors recognise ligands from cancer or viral infected cells (induced-self hypothesis) and are used when cells lack or have abnormal expression of MHC-I molecules (missing-self hypothesis), which activate cytokine production and cytotoxic activity of NK and immune cells.
Ly49 receptors are expressed in some mammals including rodents, cattle, some primates but not in humans. Only one human gene homologous to rodent Ly49 receptors is found in the human genome, KLRA1P (LY49L), however, it represents a non-functional pseudogene. However killer cell immunoglobulin-like receptors (KIR) have the same function in humans. They have different molecular structure but recognise HLA class I molecules as ligands and include both inhibitory (mainly) and activating receptor |
https://en.wikipedia.org/wiki/John%20Reif | John H. Reif (born 1951) is an American academic, and Professor of Computer Science at Duke University, who has made contributions to large number of fields in computer science: ranging from algorithms and computational complexity theory to robotics. He has also published in many other scientific fields including chemistry (in particular, nanoscience), optics (in particular optical computing and design of head-mounted displays), and mathematics (in particular graph theory and game theory.
Biography
John Reif received a B.S. (magna cum laude) from Tufts University in 1973, a M.S. from Harvard University in 1975 and a Ph.D. from Harvard University in 1977.
From 1983 to 1986 he was associate professor of Harvard University, and since 1986 he has been Professor of Computer Science at Duke University. Currently he holds the Hollis Edens Distinguished Professor, Trinity College of Arts and Sciences, Duke University. From 2011 to 2014 he was Distinguished Adjunct Professor, Faculty of Computing and Information Technology (FCIT), King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
He has also contributed to bringing together various disjoint research communities working in different areas of nano-sciences by organizing (as General Chairman) annual Conferences on "Foundations of Nanoscience: Self-assembled architectures and devices" (FNANO) for last 20 years.
He has been awarded Fellow of the following organizations: American Association for the Advancement of Science, IEEE, |
https://en.wikipedia.org/wiki/KLRA1 | Killer cell lectin-like receptor subfamily A (KLRA, alternative nomenclature Ly49) is a gene cluster coding proteins from family Ly49, which are membrane receptors expressed mainly on the surface of NK cells and other cells of immune system in some mammals including rodents and cattle but not humans. Mouse Klra gene cluster is located on chromosome 6 and comprises 20-30 genes and pseudogenes, e.g. Klra1 (Ly49A). Klra gene family is highly polymorphic and polygenic and various mouse strains encode different number of Klra genes.
The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).
References
External links |
https://en.wikipedia.org/wiki/B-cell%20activating%20factor | B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257).
Structure and function
BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124. It is expressed as a membrane-bound type II transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have d |
https://en.wikipedia.org/wiki/TNFSF9 | Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene.
4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137). The 4-1BB/4-1BBL complex belongs to the TNFR:TNF superfamily, which is expressed on activated T Lymphocytes.
Structure of 4-1BB/4-1BBL complex
The 4-1BB/4-1BBL complex consists of three monomeric 4-1BBs bound to a trimeric 4-1BBL. Each 4-1BB monomer binds to two 4-1BBLs via cysteine-rich domains (CRDs). The interaction between 4-1BB and the second 4-1BBL is required to stabilize their interactions. The link with 4-1BBL is largely made up of amino acids from the dynamic loops of the CRD2 and the β sheet of CRD3 of 4-1BB, according to a detailed study of the binding between the 4-1BB and 4-1BBL interface. CRD2 amino acids (T61, Q67, and K69) interact with the AA′ loop (Y110 and G114) and the intra-H-strand loop (Q227 and Q230) of 4-1BBL to form various hydrogen bond interactions.
Application to cancer immunotherapy
Studies on the poorly immunogenic Ag104A sarcoma and the extremely tumorigenic P815 mastocytoma provided the first systematic proof that anti-4-1BB antibodies have potent anti-tumor effects. Anti-4-1BB administration to mice with the aforementioned tumors was shown to substantially inhibit tumor growth by increasing CTL activity. In the years to come, more studies |
https://en.wikipedia.org/wiki/Myelin%20protein%20zero | Myelin protein zero (P0, MPZ) is a single membrane glycoprotein which in humans is encoded by the MPZ gene. P0 is a major structural component of the myelin sheath in the peripheral nervous system (PNS). Myelin protein zero is expressed by Schwann cells and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS. Mutations in myelin protein zero can cause myelin deficiency and are associated with neuropathies like Charcot–Marie–Tooth disease and Dejerine–Sottas disease.
Structure
In humans, the gene that encodes myelin protein zero is located on chromosome 1 near the Duffy Locus or the Duffy Antigen/Chemokine Receptor. The gene is about 7,000 bases long and is divided into 6 exons. In total, myelin protein zero is 219 amino acids long and has many basic amino acid residues.
Myelin protein zero consists of an extracellular N-terminal domain (amino acids 1–124), a single transmembrane region (125-150), and a smaller positively charged intracellular region (151-219). Its cytoplasmic domain is highly positively charged but presumably does not fold into a globular structure. The extracellular domain is structurally similar to the immunoglobulin domain and therefore the protein is considered as belonging to immunoglobulin superfamily
Besides existing as a monomer, myelin protein zero is also known to form dimers and tetramers with other myelin protein zero molecules in vertebrates.
Function
The myelin sh |
https://en.wikipedia.org/wiki/Syndecan%201 | Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein.
Altered syndecan-1 expression has been detected in several different tumor types. Syndecan 1 can be a marker for plasma cells.
Structure
The syndecan-1 core protein consists of an extracellular domain which can be substituted with heparan sulfate and chondroitin sulfate glycosaminoglycan chains, a highly conserved transmembrane domain, and a highly conserved cytoplasmic domain, which contains two constant regions that are separated by a variable region. The extracellular domain can be cleaved (shed) from the cell surface at a juxtamembrane site, converting the membrane-bound proteoglycan into a paracrine effector molecule with roles in wound repair and invasive growth of cancer cells.
An exception is the prosecretory mitogen lacritin that binds syndecan-1 only after heparanase modification. Binding utilizes an enzyme- |
https://en.wikipedia.org/wiki/Idiotype | In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity-determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by:
Gene rearrangement
Junctional diversity
P-nucleotides (palindromic nucleotides at sites of single-strand breaks)
N-nucleotides
Somatic hypermutations
Etymology and usage
The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus, idiotype describes the distinctive sequence and region that makes any immunoglobulin/TCR unique from others of the same type which is its variable region.
The term "idiotype" is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.
The word "idiotype" became influential in immunology when Niels Jerne formulated his immune network theory. Jerne was awarded the Nobel Prize in Physiology or Medicine in 1984 largely for being the father of immune network theory. He defined idiot |
https://en.wikipedia.org/wiki/Odd%E2%80%93even%20sort | In computing, an odd–even sort or odd–even transposition sort (also known as brick sort or parity sort) is a relatively simple sorting algorithm, developed originally for use on parallel processors with local interconnections. It is a comparison sort related to bubble sort, with which it shares many characteristics. It functions by comparing all odd/even indexed pairs of adjacent elements in the list and, if a pair is in the wrong order (the first is larger than the second) the elements are switched. The next step repeats this for even/odd indexed pairs (of adjacent elements). Then it alternates between odd/even and even/odd steps until the list is sorted.
Sorting on processor arrays
On parallel processors, with one value per processor and only local left–right neighbor connections, the processors all concurrently do a compare–exchange operation with their neighbors, alternating between odd–even and even–odd pairings. This algorithm was originally presented, and shown to be efficient on such processors, by Habermann in 1972.
The algorithm extends efficiently to the case of multiple items per processor. In the Baudet–Stevenson odd–even merge-splitting algorithm, each processor sorts its own sublist at each step, using any efficient sort algorithm, and then performs a merge splitting, or transposition–merge, operation with its neighbor, with neighbor pairing alternating between odd–even and even–odd on each step.
Batcher's odd–even mergesort
A related but more efficien |
https://en.wikipedia.org/wiki/Demon%20prince | Demon prince or prince demon may refer to:
Classification of demons
Demon Princes, a series of science-fiction novels
The Demon Prince of Momochi House, a Japanese romance manga
Demon Prince Enma, a Japanese horror anime and manga
Prince demons, a type of monsters in the Dungeons & Dragons setting
See also
Demon
Demonology
Warhammer Fantasy (setting)
List of Dungeons & Dragons deities |
https://en.wikipedia.org/wiki/Emmanuel%20Alo | Emmanuel Babatunde Alo (born April 15, 1950) is a Nigerian professor of applied biology, ecosystems, entomology and parasitology.
Background
Alo is noted for his research work on the transmission patterns of the HIV virus in the ABO and Rhesus blood groups. Alo's extensive research work on the almost extinct species of Dennettia tripetala is carried by the Chinese Government's National Science and Technology Library, the Institute for Scientific and Technical Information (INIST) of the French National Center for Scientific Research (CNRS) and the United Kingdom's Department for Environment, Food and Rural Affairs.
In 1991 Alo was appointed as the first Dean and founder of the School of Postgraduate Studies at the Federal University of Technology Yola. He went on to serve as the university's Deputy Vice-Chancellor from 1996 to 2000, and as interim Vice-Chancellor in 2001. He is also a chair member of the Executive Leadership Board of Rotary International District 9125.
Selected works
United Nations' Aquatic sciences and fisheries abstracts, Volume 19,(Published 1989), integrated pest management for developing countries (Nova Science Publishers, 2007) Crop Post-Harvest: Science and Technology, Volume 2 (Wiley-Blackwell;edition 1, November 5, 2004),
Advances in Virus Research, Vol. 53 Academic Press; 1 edition (October 25, 1999) and Extension Services in Wildlife Conservation: The Extension Agent and Information Worker, 22:267-269 Cambridge University Press.
Current advan |
https://en.wikipedia.org/wiki/Nina%20and%20the%20Neurons | Nina and the Neurons is a British television programme shown on the CBeebies channel, aimed at young children to help them understand basic science. Nina is a neuroscientist who enlists the help of five Neurons (animated characters representing the senses) in her brain to answer a scientific question.
The show is produced by Lucille McLaughlin, who has also produced the children's programmes Balamory, Me Too! and Bits and Bobs. The series is commissioned by CBeebies Controller, Michael Carrington
Synopsis
Most of the show is based at Glasgow Science Centre, with a little part taking place outdoors. At the start of the show, Nina conducts experiments in front of an unseen audience of children. At one point of the show, Nina is 'contacted' by (usually two or three, but rarely four) children, who appear on a computer screen asking a science-related question (e.g., 'What makes rainbows appear and disappear?') Nina then chooses one (or more) of the five Neurons inside her brain based upon which of the senses is most appropriate to answer the question. Once the Neuron has been selected by Nina, the children (called the 'experimenters') then visit Nina, using fun experiments and games.
Afterwards, Nina takes the children out to find out more about the answer to the question, sometimes with the help of their friends and family. After they have found out the answer to the question, they travel back to the Glasgow Science Centre to do another experiment and then, the 'experimenters |
https://en.wikipedia.org/wiki/Norman%20Breslow | Norman Edward Breslow (February 21, 1941 – December 9, 2015) was an American statistician and medical researcher. At the time of his death, he was Professor (Emeritus) of Biostatistics in the School of Public Health, of the University of Washington. He is co-author or author of hundreds of published works during 1967 to 2015.
Among his many accomplishments is his work with co-author Nicholas Day that developed and popularized the use of case-control matched sample research designs, in the two-volume work Statistical Methods in Cancer Research. This was with view that matched sample studies have a role within larger program of many types of studies, in making progress on a vast and important problem like cancer. Matched sample studies can quickly and cheaply test some hypothesized relationships, but their apparent findings are not definitive, and there's much they cannot accomplish. Their results, however, can inform the design of slow and expensive longitudinal large-cohort studies that are definitive, for example. Dose-response studies and other studies, too, are elements of a rational scientific program to address cancer. In 2015, he died of prostate cancer.
Breslow was an Honorary Fellow of the Royal Statistical Society of the U.K. His other professional awards an honors include: ``the Speigelman Gold Medal Award from the American Public Health Association (1978); the Snedecor Award (1995) and R.A. Fisher Award (1995) from the Committee of Presidents of Statistical |
https://en.wikipedia.org/wiki/Biotinidase | Biotinidase (, amidohydrolase biotinidase, BTD), also known as biotinase, is an enzyme that in humans is encoded by the BTD gene.
The enzyme breaks down biotin amides, releasing free biotin and the amine. The main substrate is biocytin, or biotin linked to lysine. It is also capable of breaking apart biotin esters.
Function
This enzyme allows the body to use and to recycle the B vitamin biotin, sometimes called vitamin H. Biotinidase extracts biotin from food because the body needs biotin in its free, unattached form. This enzyme also recycles biotin from enzymes in the body that use it as a helper component in order to function. These enzymes, known as carboxylases, are important in the processing of fats, carbohydrates, and proteins. Biotin is attached to these carboxylase enzymes through an amino acid (the building material of proteins) called lysine, forming a complex called biocytin. Biotinidase removes biotin from biocytin and makes it available to be reused by other enzymes.
Clinical significance
Biotin, sometimes called vitamin H, is an important water-soluble vitamin that aids in the metabolism of fats, carbohydrates and proteins. The human body cannot produce biotin, but it can obtain it from the diet, internal recycling and at some extent from intestinal bacteria. Biotin deficiency can result in behavioral disorders, lack of coordination, learning disabilities and seizure.
Unlike most vitamins, which are noncovalently bound to enzymes, biotin is chemically |
https://en.wikipedia.org/wiki/Ribosomal%20protein%20S6 | Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.
Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate eS6 and that S6K1 and S6K2 predominate this function.
Pathways leading to the induction of human eS6 phosphorylation have been found to enhance IL-8 protein synthesis. This mechanism is dependent on A/U-rich proximal sequences (APS) found in the 3'UTR of IL-8 immediately after the stop codon.
References
External links
Ribosomal proteins |
https://en.wikipedia.org/wiki/1950%E2%80%9351%20Serie%20A | The 1950–51 Serie A season was won by Milan.
Teams
Napoli and Udinese had been promoted from Serie B.
Final classification
Results
Top goalscorers
References and sources
Almanacco Illustrato del Calcio - La Storia 1898-2004, Panini Edizioni, Modena, September 2005
External links
:it:Classifica calcio Serie A italiana 1951 - Italian version with pictures and info.
- All results on RSSSF Website.
Serie A seasons
Italy
1950–51 in Italian football leagues |
https://en.wikipedia.org/wiki/ANF%20Les%20Mureaux%20113 | The ANF Les Mureaux 110 and its derivatives were a family of French reconnaissance aircraft developed in the 1930s. They were all-metal, parasol-wing monoplanes with the pilot and observer in tandem open cockpits. The type was widely used in the Battle of France, but were all scrapped soon afterwards.
Development
The ANF Les Mureaux 110 originated with a French air ministry requirement for an aircraft to replace the Breguet 19 in Armée de l'Air service in the "R2" two-seat reconnaissance role. Two slightly different variants, the 110 and 111 were presented to the air force for evaluation, and were soon ordered into production.
The first mass-production version was the 113 in 1933, of which 49 examples were purchased. This was supplanted in production by the 115 in 1935 and the 117 later than year. Both these series were given light bombing capability as well.
Operational history
The 113 entered service initially with the Armée de l'Air's reconnaissance Groupes, followed by the observation Groupes, and finally replacing the ageing Potez 25s in the Groupes Aériens Régionaux reserve units. It was followed into service by the 117 and 115. From 1934 to 35, 40 of the original 113s were converted into night fighters and used to replace the Breguet 19s still in service with France's two nightfighter Groupes.
By the outbreak of World War II, the 115 equipped nine Groupes Aériens d'Observation, and the 117 nine more. By April 1940, 11 aircraft had been lost in action, leaving 228 o |
https://en.wikipedia.org/wiki/Crosaire | John Derek Crozier (12 November 1917 – 3 April 2010), under the pseudonym "Crosaire" (), was the compiler of the cryptic crossword in The Irish Times from its inception in 1943 until the year after his death. It was formally named "The Irish Times Crossword", as opposed to the non-cryptic "Simplex crossword" which was published alongside it from 1951. As Crozier was the sole cryptic compiler for 68 years, the crossword itself became known as "the Crosaire" by metonymy. The pseudonym "Crosaire" is a play on his own surname and crosaire, the Irish for "crossroad". After Crozier's death, The Irish Times formally renamed its cryptic crossword in his honour.
Biography
Crozier was born in Dublin and educated at Castle Park preparatory school in Dalkey and Repton School in England. He graduated from Trinity College Dublin in 1940. He worked in administration at the Guinness Brewery in St. James's Gate. He first compiled a crossword to amuse his wife, Marjorie, who remained much better at solving them than her husband. Soon after, he was introduced by Jack White to Irish Times editor Bertie Smyllie at the paper's 1942 Christmas party in a Dublin pub, where he claimed that compiling crosswords was a longstanding hobby and persuaded Smyllie to commission some, the first printed on 13 March 1943. Initially the Crosaire appeared weekly on Saturdays, with Wednesdays added in 1950, Tuesdays in 1955, and a daily puzzle from 1982.
In 1948 Crozier emigrated to Southern Rhodesia, now Zimb |
https://en.wikipedia.org/wiki/Elisabeth%20%28Elisabeth%20Andreassen%20album%29 | Elisabeth is a 1990 album by Norwegian singer Elisabeth Andreassen. The song "Jag ser en stjärna falla" earned her a seventh-place finish in Melodifestivalen 1990, the Swedish qualifier for the Eurovision Song Contest 1990.
Track listing
Side A
"Varje gång du rör mig"
"Kvinna för dig"
"Nä, nä, nä (Rätt eller fel)"
"Vänskapen består" ("That's why I fell in Love with You")
"Ta mig" ("For True Love")
Side B
"Jag ser en stjärna falla"
"Segla med mig"
"Kortet de' e' lagt"
"Kärlek som din" - ("A Lover Like You") - duet with Tommy Nilsson
"Utan dig"
"Kylig natt" ("Looks Like It's Gonna Rain Today")
Participating musicians
Lasse Jonsson – guitar
Bosse Persson – bass
Lasse Persson – drums
Hans Gardemar – keyboard
References
1990 albums
Elisabeth Andreassen albums |
https://en.wikipedia.org/wiki/Dullard%20protein | In cell biology, Dullard protein is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus. The gene promotes neural development by inhibiting Bone Morphogenetic Proteins (BMPs). Dullard is also known as CTDnep1, which stands for CTD nuclear envelope phosphatase 1. This gene is relatively small and only contains 244 amino acids.
Description
Dullard is also known as CTDnep1, which stands for CTD nuclear envelope phosphatase 1. It is a protein coding gene, which include phosphatase activity and protein serine/threonine phosphatase activity. This gene is relatively small and only contains 244 amino acids. Dullard protein or CTDnep1 encodes a protein serine/threonine phosphatase and dephosphoroylates LPIN1 and LPIN2. LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglycerol. The reaction can affect and change the lipid concentration of the endoplasmic reticulum and the nucleus.
Dullard and BNP signaling
Neural development happens in the dorsal ectoderm. In the genus Xenopus, over expression of Dullard undergoes apoptosis in early development. Dullard helps promote Ubiquitin by proteosomal degradation. Dullard mRNA is derived from maternal genes and is localized within the animal neural hemisphere. Functioning negatively for the regulation of Bone Morphogenetic Proteins (BMPs), Dullard conserves the C-terminal region of NLI-IF, in |
https://en.wikipedia.org/wiki/Upu | Upu or Apu, also rendered as Aba/Apa/Apina/Ubi/Upi, was the region surrounding Damascus of the 1350 BC Amarna letters. Damascus was named Dimašqu / Dimasqu / etc. (for example, "Dimaški"-(see: Niya (kingdom)), in the letter correspondence.
The region is only referenced in three letters, EA 53, 189, and 197 (EA is for 'el Amarna'). Etakkama of Qidšu (Kadesh) in the Beqaa (named the Amqu) is in partial control, between allegiance to Pharaoh, and conjoining forces with the king of Hatti.
An example of the intrigue is from the last third of EA 53, (entitled: "Of the villain Aitukama"):
My lord, if he (i.e. pharaoh) makes this land a matter of concern to my lord, then may my lord send archers that they may come here. (Only) messengers of my lord have arrived here.
My lord, if Arsawuya of Ruhizzi and Teuwatti of Lapana remain in Upu, and Tašša (Tahash) remains in the Am[q], my lord should also know about them that Upu will not belong to my lord. Daily they write to Aitukama (Etakkama) and say as follows: "Come, tak[e] Upu in its entirety."
My lord, just as Dimaški (Damascus) in Upu (falls) at your feet, so may Qatna (fall) at your feet. My lord, one asks for life before my messenger. I do not fear [at al]l in the presence of the archers of my lord, since the archers belong to my lord. If he sends (them) to me, they will en[ter] Qatna. -EA 53, (only lines 52-70(End)).
The intrigue of the three Amarna letters appears to involve areas to the north and northwest of Damascus, into |
https://en.wikipedia.org/wiki/Mixed%20%28United%20Kingdom%20ethnicity%20category%29 | Mixed is an ethnic group category that was first introduced by the United Kingdom's Office for National Statistics for the 2001 Census. Colloquially it refers to British citizens or residents whose parents are of two or more different races or ethnic backgrounds. The Mixed or Multiple ethnic group in England and Wales numbered 1.7 million in the 2021 census, 2.9% of the population.
Statistics
A number of academics have pointed out that the ethnicity classification employed in the census and other official statistics in the UK since 1991 involve confusion between the concepts of ethnicity and race. Aspinall notes that sustained academic attention has been focused on "how the censuses measure ethnicity, especially the use of dimensions that many claim have little to do with ethnicity, such as skin colour, race, and nationality".
2001 was the first census which asked about mixed race identity. In that census, 677,177 classified themselves as of mixed ethnicity, making up 1.2 percent of the UK population. The 2011 Census gave the figure as 2.2% for England and Wales.
Office for National Statistics estimates suggest that 956,700 mixed-ethnicity people were resident in England (as opposed to the whole of the UK) as of mid-2009, compared to 654,000 at mid-2001. As of May 2011, this figure surpassed 1 million. It was estimated in 2007 that, by 2020, 1.24 million people in the UK would be of mixed race.
Research conducted by the BBC, however, suggests that the mixed race populatio |
https://en.wikipedia.org/wiki/1952%E2%80%9353%20Serie%20A | The 1952–53 Serie A season was won by Internazionale.
Teams
Roma had been promoted from Serie B.
Final classification
Results
Top goalscorers
References and sources
Almanacco Illustrato del Calcio - La Storia 1898-2004, Panini Edizioni, Modena, September 2005
External links
- All results on RSSSF Website.
Serie A seasons
Italy
1952–53 in Italian football leagues |
https://en.wikipedia.org/wiki/Birmingham%20ElectroAcoustic%20Sound%20Theatre | Birmingham ElectroAcoustic Sound Theatre, or as it is more commonly known, BEAST, is a sound diffusion system specifically designed for the performance of electroacoustic music. It consists of a set of loudspeakers connected to a computer, usually controlled by a diffusion console. It is a long-running project of the Electroacoustic Music Studios at the University of Birmingham, founded in 1982 under the directorship of Jonty Harrison. Since 2014 BEAST has been directed by Scott Wilson, along with Annie Mahtani and James Carpenter as technical director.
The loudspeakers
BEAST can consist of up to over 100 channels of loudspeakers, often arranged largely in pairs or rings,, and includes ultra-low frequency loudspeakers (bins) and custom-built trees of high frequency speakers (tweeter trees) which can be suspended above an audience.
The minimum set-up that BEAST would ordinarily use for stereo diffusion comprises a set of loudspeakers which Jonty Harrison terms the Main Eight. These four pairs of loudspeakers, using BEAST nomenclature, are termed Main, Wide, Distant and Rear. The Main and the Wide speakers together form the main, frontal sound image, the Main speakers being placed to act somewhat like the loudspeakers in a typical studio, and the Wide speakers acting to stretch that sound image out across the audience's sound stage. The Rear speakers, which are behind the audience, provide immersion and the possibility of movement around the audience. Finally, the Distant sp |
https://en.wikipedia.org/wiki/Tuberomammillary%20nucleus | The tuberomammillary nucleus (TMN) is a histaminergic nucleus located within the posterior third of the hypothalamus. It is part of the tuber cinereum. It largely consists of histaminergic neurons (i.e. histamine-releasing neurons). It is involved with the control of arousal, learning, memory, sleep and energy balance.
Efferents
The tuberomammillary nucleus is the sole source of histamine pathways in the human brain. The densest axonal projections from the tuberomammillary nucleus are sent to the cerebral cortex, hippocampus, neostriatum, nucleus accumbens, amygdala, and other parts of the hypothalamus. The projections to the cerebral cortex directly increase cortical activation and arousal, and projections to acetylcholinergic neurons of the basal forebrain and dorsal pons do so indirectly, by increasing the release of acetylcholine in the cerebral cortex.
References
Hypothalamus |
https://en.wikipedia.org/wiki/Flounce | Flounce may refer to:
Flounce (fabric), particular type of fabric manipulation that creates a similar look to ruffle but with less bulk
Flounce (physics) or crackle, in physics, the fifth derivative of the position vector with respect to time |
https://en.wikipedia.org/wiki/Shenyang%20Olympic%20Sports%20Center%20Stadium | The Shenyang Olympic Sports Centre Stadium () is a 60,000-seat multi-purpose stadium in Shenyang, Liaoning, China. It is part of the Shenyang Olympic Sports Centre.
Nicknamed "Crystal Crown" 水晶皇冠, the stadium was built by AXS Satow as a replacement for Wulihe Stadium. It hosted football matches at the 2008 Summer Olympics. It was the home ground of the Shenyang Dongjin F.C., a club that folded in 2018. In 2013 the stadium was the principal venue of the 2013 National Games of China with the opening and closing ceremonies as well as the main athletic events.
The complex includes a 10,000-seat gymnasium, a 4,000-seat natatorium, and a 4,000-seat tennis field.
External links
Beijing Olympics 2008 official website
Liaoning 2013 China's Twelfth National Games official website
References
Buildings and structures in Shenyang
Sport in Shenyang
Football venues in China
Athletics (track and field) venues in China
Venues of the 2008 Summer Olympics
Olympic football venues
Multi-purpose stadiums in China
Sports venues in Liaoning
Sports venues completed in 2007 |
https://en.wikipedia.org/wiki/Acousmonium | The Acousmonium is the sound diffusion system designed in 1974 by Francois Bayle and used originally by the Groupe de Recherches Musicales at the Maison de Radio France. It consists of 80 loudspeakers of differing size and shape, and was designed for tape playback. As Bayle wrote in a CD sleeve note in 1993, it was The process of distributing compositions of electroacoustic music or Musique concrète across an acousmonium is called diffusion. This is done by the composer or a performer by controlling and adjusting the spatial distribution and volume of the music during playback.
The Acousmonium has been in use more recently. It was, for example, used for a series of concerts held at the Institute of Contemporary Arts, London in May, 2006.
See also
Acousmatic music
Birmingham ElectroAcoustic Sound Theatre
References
Electronic musical instruments |
https://en.wikipedia.org/wiki/Erd%C5%91s%E2%80%93Stone%20theorem | In extremal graph theory, the Erdős–Stone theorem is an asymptotic result generalising Turán's theorem to bound the number of edges in an H-free graph for a non-complete graph H. It is named after Paul Erdős and Arthur Stone, who proved it in 1946, and it has been described as the “fundamental theorem of extremal graph theory”.
Statement for Turán graphs
The extremal number ex(n; H) is defined to be the maximum number of edges in a graph with n vertices not containing a subgraph isomorphic to H; see the Forbidden subgraph problem for more examples of problems involving the extremal number. Turán's theorem says that ex(n; Kr) = tr − 1(n), the number of edges of the Turán graph T(n, r − 1), and that the Turán graph is the unique such extremal graph. The Erdős–Stone theorem extends this result to H = Kr(t), the complete r-partite graph with t vertices in each class, which is the graph obtained by taking Kr and replacing each vertex with t independent vertices:
Statement for arbitrary non-bipartite graphs
If H is an arbitrary graph whose chromatic number is r > 2, then H is contained in Kr(t) whenever t is at least as large as the largest color class in an r-coloring of H, but it is not contained in the Turán graph T(n,r − 1), as this graph and therefore each of its subgraphs can be colored with r − 1 colors.
It follows that the extremal number for H is at least as large as the number of edges in T(n,r − 1), and at most equal to the extremal function for Kr(t); that is,
For |
https://en.wikipedia.org/wiki/Dasepo%20Naughty%20Girls | Dasepo Naughty Girls (; lit. "Dasepo Girl" or "Multi-cell Girl") is a 2006 South Korean musical comedy film. It is based on the popular webtoon Dasepo Girls by B-rate Dalgung (Chae Jeong-taek), which has also been adapted into a TV series.
Plot
The film takes place at Musseulmo High School (무쓸모고등학교 in Korean, literally "Useless High School"), situated somewhere in South Korea.
One of the students there is named "Poor Girl" (Kim Ok-bin). She walks around with a stuffed doll draped around her back, which she calls "Poverty." As her name implies, she comes from a very poor family. She lives with her mother (Im Ye-jin) in a one-room building. Her mother is chronically ill and buried in debt. To help pay for her mother's bills, Poor Girl has turned to prostitution to support her family. Because of this, she carries a heavy burden of guilt and shame, so much so that she has attempted suicide. Her only friend seems to be her doll, but then she meets and bonds with a new client.
The new client is a cross-dresser (Lee Won-jong), who's looking for a girl to play sisters with. Poor Girl is able to share some of her problems with her new-found friend. In the meantime, she dreams about dating her classmate Anthony (Park Jin-woo).
Anthony comes from a rich background. His adoptive parents are diplomats from Switzerland. Anthony goes through life as a materialistic, shallow person until he meets Double Eyes (Lee Eun-sung).
Double Eyes is the sister of Anthony's classmate Cyclops (Lee K |
https://en.wikipedia.org/wiki/BioBrick | BioBrick parts are DNA sequences which conform to a restriction-enzyme assembly standard. These building blocks are used to design and assemble larger synthetic biological circuits from individual parts and combinations of parts with defined functions, which would then be incorporated into living cells such as Escherichia coli cells to construct new biological systems. Examples of BioBrick parts include promoters, ribosomal binding sites (RBS), coding sequences and terminators.
Overview
The BioBrick parts are used by applying engineering principles of abstraction and modularization. BioBrick parts form the base of the hierarchical system on which synthetic biology is based. There are three levels to the hierarchy:
Parts: Pieces of DNA that form a functional unit (for example promoter, RBS, etc.)
Device: Collection set of parts with defined function. In simple terms, a set of complementary BioBrick parts put together forms a device.
System: Combination of a set of devices that performs high-level tasks.
The development of standardized biological parts allows for the rapid assembly of sequences. The ability to test individual parts and devices to be independently tested and characterized also improves the reliability of higher-order systems.
History
The first attempt to create a list of standard biological parts was in 1996, by Rebatchouk et al. This team introduced a cloning strategy for the assembly of short DNA fragments. However, this early attempt was not widely re |
https://en.wikipedia.org/wiki/Cultured%20neuronal%20network | A cultured neuronal network is a cell culture of neurons that is used as a model to study the central nervous system, especially the brain. Often, cultured neuronal networks are connected to an input/output device such as a multi-electrode array (MEA), thus allowing two-way communication between the researcher and the network. This model has proved to be an invaluable tool to scientists studying the underlying principles behind neuronal learning, memory, plasticity, connectivity, and information processing.
Cultured neurons are often connected via computer to a real or simulated robotic component, creating a hybrot or animat, respectively. Researchers can then thoroughly study learning and plasticity in a realistic context, where the neuronal networks are able to interact with their environment and receive at least some artificial sensory feedback. One example of this can be seen in the Multielectrode Array Art (MEART) system developed by the Potter Research Group at the Georgia Institute of Technology in collaboration with SymbioticA, The Centre for Excellence in Biological Art, at the University of Western Australia. Another example can be seen in the neurally controlled animat.
Use as a model
Advantages
The use of cultured neuronal networks as a model for their in vivo counterparts has been an indispensable resource for decades. It allows researchers to investigate neuronal activity in a much more controlled environment than would be possible in a live organism. Through |
https://en.wikipedia.org/wiki/Cytopathic%20effect | Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to structural changes in host cells that are caused by viral invasion. The infecting virus causes lysis of the host cell or when the cell dies without lysis due to an inability to replicate. Both of these effects occur due to CPEs. If a virus causes these morphological changes in the host cell, it is said to be cytopathogenic. Common examples of CPE include rounding of the infected cell, fusion with adjacent cells to form syncytia, and the appearance of nuclear or cytoplasmic inclusion bodies.
CPEs and other changes in cell morphology are only a few of the many effects by cytocidal viruses. When a cytocidal virus infects a permissive cell, the viruses kill the host cell through changes in cell morphology, in cell physiology, and the biosynthetic events that follow. These changes are necessary for efficient virus replication but at the expense of the host cell.
Diagnostics
CPEs are important aspects of a viral infection in diagnostics. Many CPEs can be seen in unfixed, unstained cells under the low power of an optical microscope, with the condenser down and the iris diaphragm partly closed. However, with some CPEs, namely inclusion bodies, the cells must be fixed and stained then viewed under light microscopy. Some viruses' CPEs are characteristic and therefore can be an important tool for virologists in diagnosing an infected animal or human. The rate of CPE appearance is also an important characteristic th |
https://en.wikipedia.org/wiki/Stanu%C5%A1ina%20Crna | Stanušina Crna or Stanušina (, also rendered as Stanushina) is a red grape variety indigenous to North Macedonia and is found nowhere else in the world. Little known outside of its native country, nonetheless it is capable of producing very high quality wines and is mainly grown in the Tikveš region.
The introduction of international grape varieties have caused a sharp decline of Stanušina from the country’s vineyards in recent times, threatening to wipe out this local variety of grape forever. Realizing this, local wineries have begun initiatives to reintroduce this uniquely old Macedonian domestic variety back into the region.
The grapevine is highly resistant to drought and pests and can be cultivated without irrigation. The fruit ripens very late but gives good yields, producing on average 15-20 t/ha. The juice obtained contains approx 18-20% sugar and 6-9 g/L acids. During a good year, it can provide a base for wine of high quality and medium strength, with 11-12% of alcohol. Rich in extract but characteristically pale in color, the high level of acid gives the wine excellent freshness and is recommended to be taken at a temperature of 10-16°C. Stanušina typically has a light strawberry, raspberry, blackcurrant and dry leaf aroma. It makes an excellent complement to white and yellow cheeses, light and creamy desserts, leaf salads, nuts and sweets.
Kavadarka
Kavadarka () is one of the oldest and most popular wines in North Macedonia. It is made from the grape Sta |
https://en.wikipedia.org/wiki/Hammerhead%20ribozyme | The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule. It is one of several catalytic RNAs (ribozymes) known to occur in nature. It serves as a model system for research on the structure and properties of RNA, and is used for targeted RNA cleavage experiments, some with proposed therapeutic applications. Named for the resemblance of early secondary structure diagrams to a hammerhead shark, hammerhead ribozymes were originally discovered in two classes of plant virus-like RNAs: satellite RNAs and viroids. They are also known in some classes of retrotransposons, including the retrozymes. The hammerhead ribozyme motif has been ubiquitously reported in lineages across the tree of life.
The self-cleavage reactions, first reported in 1986, are part of a rolling circle replication mechanism. The hammerhead sequence is sufficient for self-cleavage and acts by forming a conserved three-dimensional tertiary structure.
Catalysis
In its natural state, a hammerhead RNA motif is a single strand of RNA. Although the cleavage takes place in the absence of protein enzymes, the hammerhead RNA itself is not a catalyst in its natural state, as it is consumed by the reaction (i.e. performs self-cleavage) and therefore cannot catalyze multiple turnovers.
Trans-acting hammerhead constructs can be engineered such that they consist of two interacting RNA strands, with one strand composing a hammerhead ribozyme t |
https://en.wikipedia.org/wiki/Glutamate%20carboxypeptidase%20II | Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa.
GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right.
Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All refer to the same protein glutamate carboxypeptidase II.
Discovery
GCPII is mainly expressed in four tissues of the body, including prostate epithelium, the proximal tubules of the kidney, the jejunal brush border of the small intestine and ganglia of the nervous system.
Indeed, the initial cloning of the cDNA encoding the gene expressing PSMA was accomplished with RNA from a prostate tumor cell line, LNCaP. PSMA shares homology with the transferrin receptor and undergoes endocytosis but the ligand for inducing internalization has not been identified. It was found that PSMA was the same as the membrane protein in the small intestine responsible for removal of gamma-link |
https://en.wikipedia.org/wiki/Ventral%20posterolateral%20nucleus | The ventral posterolateral nucleus (VPL) is a nucleus of ventral posterior nucleus of the thalamus. It relays sensory information from the second-order neurons of the neospinothalamic tract and medial lemniscus (of the posterior column-medial lemniscus pathway) which synapse with in the third-order neurons in the nucleus. These then project to the somatosensory cortex in the postcentral gyrus.
There is uncertainty regarding the location of VMpo, as determined by spinothalamic tract (STT) terminations and staining for calcium-binding proteins, and several authorities do not consider its existence as being proved.
Anatomy
Subdivisions
The nucleus ventralis posterior lateralis pars oralis (VPLo) is a subdivision of the ventral posterolateral thalamus which has substantial projections to the motor cortex.
Additional images
References
Thalamus |
https://en.wikipedia.org/wiki/Artificial%20chromosome | Artificial chromosome may refer to:
Yeast artificial chromosome
Bacterial artificial chromosome
Human artificial chromosome
P1-derived artificial chromosome
Synthetic DNA of a base pair size comparable to a chromosome |
https://en.wikipedia.org/wiki/WKTK | WKTK (98.5 FM) is a commercial radio station licensed to Crystal River, Florida, and serving the Gainesville–Ocala radio market. It is owned by Audacy, Inc., and carries an adult contemporary radio format, switching to Christmas music for much of November and December.
WKTK has an effective radiated power (ERP) of 100,000 watts, currently the maximum for FM stations in Florida. Its strong signal can be picked up in portions of Orlando, Jacksonville, and the Tampa Bay Area.
History
On , the station signed on the air. Its call sign was originally WRYO. The station was owned by the Cape Christian Broadcasters of Florida, and it had a Christian radio format. It used United Press International for its news service.
The call letters WKTK ("Koast-to-Koast", referring to the station's large coverage area stretching from the Atlantic Ocean to the Gulf of Mexico) were adopted in 1986. WKTK has been through various forms of the adult contemporary and hot AC formats since before finally settling into the mainstream AC sound it now uses.
On May 19, 2008, utilizing iBiquity's in-band on-channel (IBOC) digital radio technology, WKTK-FM began broadcasting its signal in both digital (HD-1) and analog (FM) formats. In addition to the digital launch, WKTK-HD2 began broadcasting the area's only all digital, all blues music format, branded as The Swamp WKTK-HD2 (98.5-2). The station was granted special permission to use "The Swamp" from The University of Florida in homage of the school |
https://en.wikipedia.org/wiki/Intralaminar%20thalamic%20nuclei | The intralaminar thalamic nuclei (ITN) are collections of neurons in the internal medullary lamina of the thalamus that are generally divided in two groups as follows:
anterior (rostral) group
central medial nucleus
paracentral nucleus
central lateral nucleus
posterior (caudal) intralaminar group
centromedian nucleus
parafascicular nucleus
Some sources also include a "central dorsal" nucleus.
Degeneration of this area can be associated with progressive supranuclear palsy and Parkinson's disease. Additionally, infarction of the thalamic paramedian artery may result in varied features such as disorientation, confusion, hypersomnolence, deep coma, or akinetic mutism. This area is also prominently affected in traumatic brain injuries. One postmortem study of patients with closed head injuries showed correlation of the involvement of these nuclei with the various degrees of disability.
See also
Central tegmental tract
Output of the ARAS
References
External links
Diagram at University of Florida
Thalamic nuclei |
https://en.wikipedia.org/wiki/Father%20Roquelaure | Father Roquelaure is a French fairy tale collected by Achille Millien.
It is a type 516 tale in the Aarne-Thompson classification system. Others of this type are Trusty John and The Raven.
Synopsis
A widowed queen urges her son, Emilien, to marry, but he does not. She dies. One day, he sees a portrait of the Princess Emilienne and falls in love. The portrait painter tells him that the princess is kept confined in a tower by a fairy. Emilien confides in a trusted servant, Jean, and after Jean makes secret preparations, they set out to find the princess. They take turns keeping watch at night.
While the prince sleeps, Jean hears voices talking. One is of Father Roquelaure, who tells how Prince Emilien's task of finding the princess will be hard. He will have to rub the wheels with moss to cross a river with no bridge, which will create a bridge; he will have to offer the fairy a distaff with diamonds and then give her a sleeping potion; when he takes the princess, his horses will refuse to go on, and he will have to refuse offers from coachmen with horses and carriages and instead dash them to pieces; when the princess becomes thirsty and vendors offer to sell her drinks, the drinks will be poison and he will have to dash them to the ground; they will come upon a drowning man, and the prince will have to push him back into the water rather than rescue him; finally, he will have to rub the wheels with moss again. And if he repeats any of the things he has just been |
https://en.wikipedia.org/wiki/B1%20cell | B1 cells are a sub-class of B cell lymphocytes that are involved in the humoral immune response. They are not part of the adaptive immune system, as they have no memory, but otherwise, B1 cells perform many of the same roles as other B cells: making antibodies against antigens and acting as antigen-presenting cells. These B1 cells are commonly found in peripheral sites, but less commonly found in the blood. These cells are involved in antibody response during an infection or vaccination.
There are two types of B1 cells subsets, B1a cells and B1b cells. B1b cells have been shown to be capable of memory responses. B1b cells also can recognize protective antigens in bacteria, which is unique because they are targeting something internal.
Origin
B1 cells are first produced in the fetus and most B1 cells undergo self-renewal in the periphery, unlike conventional B cells (B2 cells) that are produced after birth and replaced in the bone marrow.
Types
Human B1 cells have been found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been debated since. CD5-CD72 is thought to mediate B cell-B cell interaction. What differentiates B1 cells from other B cells is the variable existence of CD5, CD86, IgM and IgD. B-1 B cells, in the mouse, can be further subdivided into B-1a (CD5+) and B-1b (CD5−) subtypes. Unlike B-1a B cells, the B-1b subtype can be generated from precursors in the adult bone marrow. The B1a and B1b precursors have been repor |
https://en.wikipedia.org/wiki/Weed%20identification | Weed identification may relate to
History of plant systematics, the classification of plants
Botany, the study of plants
Taxonomy, the classification of living things
Weed plant science
Weed (disambiguation) |
https://en.wikipedia.org/wiki/WBCR-LP | WBCR-LP is a low power FM radio station with office and studio located in Great Barrington, Massachusetts, broadcasting on the 97.7 FM frequency. The organization's legal name is "Berkshire Community Radio Alliance," and is also known as "Berkshire Community Radio" or "BCR."
WBCR-LP is a 501(c)(3) non-profit, volunteer-run, non-commercial, community radio station with over 70 locally produced shows currently on the air. With a broadcast radius between 8 and 15 miles, depending on terrain, it serves the southern portion of Berkshire County, Massachusetts. WBCR-LP also streams live on the internet.
History
WBCR-LP commenced broadcasting on October 23, 2004.
Full power upgrade
On March 31, 2010, the Federal Communications Commission (FCC) granted the licensee of WBCR-LP, Berkshire Community Radio Alliance, a construction permit for 89.5 MHz from the American Towers communications tower in Hillsdale, New York. When built, the station would have run 550 watts vertical from 144 meters above average terrain. However, in March 2013 the Board of Directors voted to remain as a low power station and turned the construction permit over to NEPR (New England Public Radio) which then constructed WNNU, basically an all news and talk station.
See also
List of community radio stations in the United States
References
External links
WBCR-LP Homepage
BCR-LP
Community radio stations in the United States
BCR-LP
Great Barrington, Massachusetts
Mass media in Berkshire County, Massachusetts
|
https://en.wikipedia.org/wiki/Mackinawite | Mackinawite is an iron nickel sulfide mineral with the chemical formula (where x = 0 to 0.11). The mineral crystallizes in the tetragonal crystal system and has been described as a distorted, close packed, cubic array of S atoms with some of the gaps filled with Fe. Mackinawite occurs as opaque bronze to grey-white tabular crystals and anhedral masses. It has a Mohs hardness of 2.5 and a specific gravity of 4.17. It was first described in 1962 for an occurrence in the Mackinaw mine, Snohomish County, Washington for which it was named.
Occurrence
Mackinawite occurs in serpentinized peridotites as a hydrothermal alteration product, in meteorites, and in association with chalcopyrite, cubanite, pentlandite, pyrrhotite, greigite, maucherite, and troilite. Mackinawite also occurs in reducing environments such as freshwater and marine sediments as a result of the metabolism of iron and sulfate-reducing bacteria.
In anoxic environments, mackinawite is formed by the reaction of HS− with either Fe2+ ions or with Fe metal. Mackinawite is a metastable mineral that occurs predominantly as a poorly crystalline precipitate. After the initiation of precipitation, mackinawite can take up to 2 years to form at 25 °C. It has been reported that mackinawite can be stable for up to 16 weeks at temperatures up to 100 °C at pH values from 3-12. Laboratories have also produced synthetic mackinawite to study its formation using several different methods such as reacting sulfide with metalli |
https://en.wikipedia.org/wiki/West%20Mallee | West Mallee is a statistical subdivision defined under the Australian Standard Geographical Classification, and therefore used by the Australian Bureau of Statistics. It is one of three subdivisions of the Mallee statistical division of the Australian state of Victoria. It consists of three statistical local areas: Buloke (S) - North, Buloke (S) - South and Mildura (RC) - Pt B.
References
External links
Demographics of Australia
Geography of Victoria (state) |
https://en.wikipedia.org/wiki/Thiamine%20monophosphate | Thiamine monophosphate is a thiamine derivative. It occurs naturally in milk.
References
Organophosphates
Thiazoles
Pyrimidines
Thiamine |
https://en.wikipedia.org/wiki/Acetyl-CoA%20synthetase | Acetyl-CoA synthetase (ACS) or Acetate—CoA ligase is an enzyme () involved in metabolism of acetate. It is in the ligase class of enzymes, meaning that it catalyzes the formation of a new chemical bond between two large molecules.
Reaction
The two molecules joined together that make up Acetyl CoA are acetate and coenzyme A (CoA). The complete reaction with all the substrates and products included is:
ATP + Acetate + CoA AMP + Pyrophosphate + Acetyl-CoA
Once acetyl-CoA is formed it can be used in the TCA cycle in aerobic respiration to produce energy and electron carriers. This is an alternate method to starting the cycle, as the more common way is producing acetyl-CoA from pyruvate through the pyruvate dehydrogenase complex. The enzyme's activity takes place in the mitochondrial matrix so that the products are in the proper place to be used in the following metabolic steps. Acetyl Co-A can also be used in fatty acid synthesis, and a common function of the synthetase is to produce acetyl Co-A for this purpose.
The reaction catalyzed by acetyl-CoA synthetase takes place in two steps. First, AMP must be bound by the enzyme to cause a conformational change in the active site, which allows the reaction to take place. The active site is referred to as the A-cluster. A crucial lysine residue must be present in the active site to catalyze the first reaction where Co-A is bound. Co-A then rotates in the active site into the position where acetate can covalently bind to CoA. The c |
https://en.wikipedia.org/wiki/Idris%20Ughiovhe | Idris "Alex" Ughiovhe (born January 27, 1983 in Washington, DC) is an American soccer player of Nigerian heritage who last played for Crystal Palace Baltimore in the USSF Second Division.
Career
Youth and college
Ughiovhe played college soccer at Howard University, and for Richmond Kickers Future in the USL Premier Development League,
Professional
Ughiovhe was drafted in the fourth round 2006 MLS Supplemental Draft by Chicago Fire, played several reserve matches for both Chicago and D.C. United, and was signed to a developmental contract by Fire on September 19, 2006, but was released before he played a game.
He signed for Crystal Palace Baltimore in the USL Second Division prior to the team's inaugural 2007 season, and made his professional debut on April 20, 2007 in Baltimore's season-opening 4–1 loss to the Charlotte Eagles.
Career statistics
(correct as of September 29, 2009)
External links
Crystal Palace Baltimore bio
References
1983 births
Living people
USL Second Division players
USL League Two players
Crystal Palace Baltimore players
Chicago Fire FC players
Howard Bison men's soccer players
Richmond Kickers Future players
African-American men's soccer players
Chicago Fire FC draft picks
Soccer players from Washington, D.C.
American men's soccer players
Men's association football defenders
21st-century African-American sportspeople
20th-century African-American people |
https://en.wikipedia.org/wiki/Bryan%20Harkin | Bryan Harkin (born October 29, 1980, in Derry) is a Northern Irish soccer player who played for Crystal Palace Baltimore in the USSF Second Division.
Career
College and amateur
Harkin played college soccer at Fairfield University in Fairfield, Connecticut from 1999 to 2002. In 2000, he set the Stags' single season assist record with 9 while helping lead the team to a No. 15 national ranking, and in 2002 he was selected as a Regional All-American by the NSCAA.
During his college years Harkin also played for the Cape Cod Crusaders in the USL Premier Development League, helping the team win the PDL National Championship in 2002.
Professional
Harkin signed for Crystal Palace Baltimore prior to the team's inaugural season in 2007, and has been ever-present since then, making 50 appearances for the club in USL Second Division and U.S. Open Cup play, and helping the team to the post-season playoffs in 2008.
Harkin was no longer with the team by the time it folded after the club had separated ties with it's parent organization, Crystal Palace F.C.
Coaching
Harkin coached the women's varsity team at Mount St. Mary's University for three years while gaining an MBA in business.
On August 24, 2009, Harkin was named a volunteer assistant coach for the men's soccer team at Loyola University Maryland. In Fall of 2014, Harkin joined Tufts Men's Soccer coaching staff as an assistant coach. He helped the Jumbos to their first ever DIII National Championship in 2014, a Sweet Sixteen app |
https://en.wikipedia.org/wiki/Erna%20Furman | Erna Furman (born Erna Mary Popper June 14, 1926 – August 9, 2002) was an Austrian-born American child psychoanalyst, psychologist, and teacher.
Biography
Furman was born Erna Mary Popper in Vienna to a Jewish family. She was educated at the Academy of Commerce in Prague. As a little girl she had been to Montessori nursery school in Vienna. In 1938, when she was twelve years old, Nazi Germany annexed Austria. Her family, having Czech citizenship, fled to Czechoslovakia to escape the Nazis. This move provided only temporary safety. In spring 1939 her father left for Belgium and England. They were to meet again only at the end of the summer of 1946.
In October 1942, Furman and her mother were sent to the Theresienstadt concentration camp, near Prague. Her aunts and grandmother would later be sent to the same concentration camp. While there, she was twice put on the list for transportation to Auschwitz. Both times she managed to have her name to be removed from that list. In January 1943, she asked the Jewish Elder to take her out of the transport. Edelstein took her out of the transport because her mother had died that morning and she'd acquired a different status due to her mother's death.
She came to Theresienstadt from Prague in October 1942, and left in May 1945 (when the Red Army liberated it), from age 16 to almost 19 years, and worked the entire time as 'Betreuerin' (caregiver) in a children's home, L 318. L 318 was one of the orphan houses in the ghetto. Later in 19 |
https://en.wikipedia.org/wiki/Statistical%20study%20of%20energy%20data | Energy statistics refers to collecting, compiling, analyzing and disseminating data on commodities such as coal, crude oil, natural gas, electricity, or renewable energy sources (biomass, geothermal, wind or solar energy), when they are used for the energy they contain. Energy is the capability of some substances, resulting from their physico-chemical properties, to do work or produce heat. Some energy commodities, called fuels, release their energy content as heat when they burn. This heat could be used to run an internal or external combustion engine.
The need to have statistics on energy commodities became obvious during the 1973 oil crisis that brought tenfold increase in petroleum prices. Before the crisis, to have accurate data on global energy supply and demand was not deemed critical. Another concern of energy statistics today is a huge gap in energy use between developed and developing countries. As the gap narrows (see picture), the pressure on energy supply increases tremendously.
The data on energy and electricity come from three principal sources:
Energy industry
Other industries ("self-producers")
Consumers
The flows of and trade in energy commodities are measured both in physical units (e.g., metric tons), and, when energy balances are calculated, in energy units (e.g., terajoules or tons of oil equivalent). What makes energy statistics specific and different from other fields of economic statistics is the fact that energy commodities undergo greater numb |
https://en.wikipedia.org/wiki/Pseudomonas%20alkanolytica | Pseudomonas alkanolytica is a Gram-negative soil bacterium that produces Coenzyme A. Because this organism is patented, it is not officially recognized as a legitimate Pseudomonas species, and therefore has no type strain. However, it is available through the American Type Culture Collection.
References
Pseudomonadales
Bacteria described in 1972 |
https://en.wikipedia.org/wiki/Pete%20Medd | Pete Medd is an American retired soccer player who was the president of Crystal Palace Baltimore. He also served as the team's co-manager along with Jim Cherneski from 2007 to 2009.
Youth
Pete Medd graduated from Middletown High School. He was the former Maryland State High School Player of the Year and led his team to the State Championship Title in 1993. In 1994, he entered Towson University where he played from 1994 to 1998. He was a four-year starter, regional first team selection and captain of Towson University. He helped lead Towson to a Division 1 Top 15 NCAA National Ranking.
Player
In 1999, Medd spent a single season with the Delaware Wizards of USISL but never featured in a game. He was also the 1999 First Round Draft Pick for the Baltimore Blast of the National Professional Soccer League. He only played in one game for the Blast during the 2000–2001 season.
Coach
In 1999, Medd became an assistant coach at Towson University, a position he held until 2001. That year, he moved to Essex Community College where he was the school's head coach. During his tenure, he led the team to a National Top 5 Ranking and was two time East Region Coach of the Year. In 2007, he was self-hired as the head coach of Crystal Palace Baltimore, a USL Second Division team associated with English club Crystal Palace F.C. The club discontinued operations in 2010.
References
1976 births
Living people
American soccer coaches
American men's soccer players
Baltimore Blast (NPSL) playe |
https://en.wikipedia.org/wiki/1953%E2%80%9354%20Serie%20A | The 1953–54 Serie A season was won by Internazionale.
Teams
Genoa and Legnano had been promoted from Serie B.
Final classification
Results
Relegation tie-breaker
Played in Milan, Florence and Rome
Palermo relegated to Serie B.
Top goalscorers
References and sources
Almanacco Illustrato del Calcio - La Storia 1898-2004, Panini Edizioni, Modena, September 2005
External links
- All results on RSSSF Website.
Serie A seasons
Italy
1953–54 in Italian football leagues |
https://en.wikipedia.org/wiki/Classification%20of%20mental%20disorders | The classification of mental disorders, also known as psychiatric nosology or psychiatric taxonomy, is central to the practice of psychiatry and other mental health professions.
The two most widely used psychiatric classification systems are chapter V of the International Classification of Diseases, 10th edition (ICD-10), produced by the World Health Organization (WHO); and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), produced by the American Psychiatric Association (APA).
Both systems list disorders thought to be distinct types, and in recent revisions the two systems have deliberately converged their codes so that their manuals are often broadly comparable, though differences remain. Both classifications employ operational definitions.
Other classification schemes, used more locally, include the Chinese Classification of Mental Disorders.
Manuals of limited use, by practitioners with alternative theoretical persuasions, include the Psychodynamic Diagnostic Manual.
Definitions
In the scientific and academic literature on the definition or categorization of mental disorders, one extreme argues that it is entirely a matter of value judgments (including of what is normal) while another proposes that it is or could be entirely objective and scientific (including by reference to statistical norms); other views argue that the concept refers to a "fuzzy prototype" that can never be precisely defined, or that the definition will always in |
https://en.wikipedia.org/wiki/Video%20game%20content%20rating%20system | A video game content rating system is a system used for the classification of video games based on suitability for target audiences. Most of these systems are associated with and/or sponsored by a government, and are sometimes part of the local motion picture rating system. The utility of such ratings has been called into question by studies that publish findings such as 90% of teenagers claim that their parents "never" check the ratings before allowing them to rent or buy video games, and as such, calls have been made to "fix" the existing rating systems. Video game content rating systems can be used as the basis for laws that cover the sales of video games to minors, such as in Australia. Rating checking and approval is part of the game localization when they are being prepared for their distribution in other countries or locales. These rating systems have also been used to voluntarily restrict sales of certain video games by stores, such as the German retailer Galeria Kaufhof's removal of all video games rated 18+ by the USK following the Winnenden school shooting.
Comparison table
A comparison of current video game rating systems, showing age on the horizontal axis. Note however that the specific criteria used in assigning a classification can vary widely from one country to another. Thus a color code or age range cannot be directly compared from one country to another.
Key:
White – No restrictions: Suitable for all ages / Aimed at young audiences / Exempt / Not ra |
https://en.wikipedia.org/wiki/Cupriavidus | Cupriavidus is a genus of bacteria that includes the former genus Wautersia. They are characterized as Gram-negative, motile, rod-shaped organisms with oxidative metabolism. They possess peritrichous flagella, are obligate aerobic organisms, and are chemoorganotrophic or chemolithotrophic. Resistance to metals (including copper) has been described. These organisms have been found in both soil and in clinical isolates.
References
External links
J.P. Euzéby: List of Prokaryotic names with Standing in Nomenclature
Burkholderiaceae
Bacteria genera |
https://en.wikipedia.org/wiki/Herbaspirillum | Herbaspirillum is a genus of bacteria, including the nitrogen-fixing Herbaspirillum lusitanum.
Although usually found in soil environments, it has also been identified as a contaminant of DNA extraction kit reagents, which may lead to its erroneous appearance in microbiota or metagenomic datasets.
References
Burkholderiales
Bacteria genera |
https://en.wikipedia.org/wiki/BMPR1B | Bone morphogenetic protein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the BMPR1B gene.
Function
BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
The BMPR1B receptor plays a role in the formation of middle and proximal phalanges.
Clinical significance
Mutations in this gene have been associated with primary pulmonary hypertension.
In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations. BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective transducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
References
External links
|
https://en.wikipedia.org/wiki/What%20Are%20You%20On%3F | What Are You On? is an album by East River Pipe, released in 2006.
Track listing
"What Does T.S. Eliot Know About You?" – 2:30
"Crystal Queen" – 2:29
"What Are You On?" – 2:02
"I'll Walk My Robot Home" – 3:09
"The Ultrabright Bitch" – 2:07
"Druglife" – 3:49
"Absolutely Nothing" – 2:12
"Dirty Carnival" – 3:06
"You Got Played, Little Girl" – 2:09
"Life Is a Landfill" – 2:57
"Shut Up and Row" – 2:17
"Trivial Things" – 2:25
"Some Dreams Can Kill You" – 5:19
References
2006 albums
East River Pipe albums |
https://en.wikipedia.org/wiki/Pioneer%20axon | Pioneer axon is the classification given to axons that are the first to grow in a particular region. They originate from pioneer neurons, and have the main function of laying down the initial growing path that subsequent growing axons, dubbed follower axons, from other neurons will eventually follow.
Several theories relating to the structure and function of pioneer axons are currently being explored. The first theory is that pioneer axons are specialized structures, and that they play a crucial role in guiding follower axons. The second is that pioneer axons are no different from follower axons, and that they play no role in guiding follower axons.
Anatomically, there are no differences between pioneer and follower axons, although there are morphological differences. The mechanisms of pioneer axons and their role in axon guidance is currently being explored. In addition, many studies are being conducted in model organisms, such grasshoppers, zebrafish, and fruit flies to study the effects of manipulations of pioneer axons on neuronal development.
History
Santiago Ramon y Cajal, considered the father of modern neuroscience, was one of the first to physically observe growing axons. Moreover, he observed that axons grew in a structured, guided manner. He advocated that axons were guided by chemotactic cues. Indeed, later experiments showed that in both invertebrate and vertebrate models, axons grew along pre-determined routes to create a reproducible scaffold of nerves.
|
https://en.wikipedia.org/wiki/Pierre%20Jean%20Robiquet | Pierre Jean Robiquet (13 January 1780 – 29 April 1840) was a French chemist. He laid founding work in identifying amino acids, the fundamental building blocks of proteins. He did this through recognizing the first of them, asparagine, in 1806, in the industry's adoption of industrial dyes, with the identification of alizarin in 1826, and in the emergence of modern medications, through the identification of codeine in 1832, an opiate alkaloid substance of widespread use with analgesic and antidiarrheal properties.
Robiquet was born in Rennes. He was at first a pharmacist in the French armies during the French Revolution years, and became a professor at the École de pharmacie in Paris, where he died.
Notable scientific achievements were among other things his isolation and characterization of properties of asparagine (the first amino acid to be identified, from asparagus, achieved. In 1806, with Louis Nicolas Vauquelin), cantharidin (1810), the sigma-1 receptor agonist noscapine (1817), caffeine (1821), alizarin (later on moved to mass industrial production by Carl Gräbe and Carl Theodore Liebermann in Germany, and by William Henry Perkin in Great Britain) and purpurin (1826), Orcin (1829), amygdalin (1830), as well as codeine (1832). Some of these discoveries were made in collaboration with other scientists.
Academic titles and distinctions
Registered Pharmacist (1808), lecturer in chemistry at the École Polytechnique (1811), Deputy Professor in History of pharmaceutical |
https://en.wikipedia.org/wiki/Statistical%20static%20timing%20analysis | Conventional static timing analysis (STA) has been a stock analysis algorithm for the design of digital circuits over the last 30 years. However, in recent years the increased variation in semiconductor devices and interconnect has introduced a number of issues that cannot be handled by traditional (deterministic) STA. This has led to considerable research into statistical static timing analysis, which replaces the normal deterministic timing of gates and interconnects with probability distributions, and gives a distribution of possible circuit outcomes rather than a single outcome.
Comparison with conventional STA
Deterministic STA is popular for good reasons:
It requires no vectors, so it does not miss paths.
The run time is linear in circuit size (for the basic algorithm).
The result is conservative.
It typically uses some fairly simple libraries (typically delay and output slope as a function of input slope and output load).
It is easy to extend to incremental operation for use in optimization.
STA, while very successful, has a number of limitations:
Cannot easily handle within-die correlation, especially if spatial correlation is included.
Needs many corners to handle all possible cases.
If there are significant random variations, then in order to be conservative at all times, it is too pessimistic to result in competitive products.
Changes to address various correlation problems, such as CPPR (Common Path Pessimism Removal) make the basic algorithm slower than line |
https://en.wikipedia.org/wiki/Amasya%20Merzifon%20Airport | Merzifon Airport or Amasya Merzifon Airport is a military airport located in the city of Merzifon in the Amasya Province of Turkey.
Airlines and destinations
Statistics
Military usage
Merzifon is the 5th Air Wing (Ana Jet Üs or AJÜ) of the 2nd Air Force Command (Hava Kuvvet Komutanligi) of the Turkish Air Force (Türk Hava Kuvvetleri). Other wings of this command are located in Malatya/Erhaç (LTAT), Diyarbakır (LTCC) and İncirlik (LTAG).
References
External links
Airports in Turkey
Turkish Air Force bases
Buildings and structures in Amasya Province
Transport in Amasya Province
Merzifon District |
https://en.wikipedia.org/wiki/Jadarite | Jadarite is a white, earthy monoclinic silicate mineral, sodium lithium boron silicate hydroxide (LiNaSiB3O7(OH) or Na2OLi2O(SiO2)2(B2O3)3H2O).
Discovery and classification
Jadarite was discovered in December 2004, in drill core from the Jadar Valley (, Jadar, pronounced /jadaɾ/) in Serbia, from which it is named. The find was located southwest of the Cer mountain. Findings were originally located in the villages of Jarebice and Slatina and later in Draginac.
Exploration geologists from Rio Tinto Exploration discovered the mineral as small rounded nodules in drill core, and were unable to match it with previously known minerals. Jadarite was confirmed as a new mineral after scientists at the Natural History Museum in London and the National Research Council of Canada conducted tests on it.
Commercialization
The mineral discovery may be commercially important because the mineral contains lithium and boron, both relatively rare industrially important elements. Lithium is used for lithium batteries; boron is used in alloys, ceramic, glasses, and other applications.
It was originally estimated that there are 200 million tons of the lithium borate ore, which would make the future Jadar mines one of the world's largest lithium deposits, supplying 10% of the world's demand for lithium. Later on, United States Geological Survey concluded that lithium supply is closer to 1.51% of world's demand for lithium. Of that, the Lower Jadar ore deposit has 114.5 million tons with an av |
https://en.wikipedia.org/wiki/Tutu%20%28Egyptian%20official%29 | Tutu was one of pharaoh's officials during the Amarna letters period 1350–1335 BC. He is only found in the body of letters from Aziru, and his son, DU-Teššup. Four of the Amarna letters—EA 158, 164, 167 and 169—are addressed to the Pharaoh, by way of Tutu. DU-Teššup's single letter is written to pharaoh because his father Aziru is being detained in Egypt, and Aziru is needed to attend to affairs at home. Unless he were to remarry he may never return home again.
Letter EA 164
The undamaged letter EA 164 "Coming, on condition" by Aziru to Tutu is a good example of the intrigues of Aziru in north Canaan, and the involvement of all the local regions, and leaders.
Other letters
EA 158, "Father and son"
EA 164, "Coming, on condition"
EA 167, "The constant Hittite menace"
EA 169, "Aziru in Egypt-(Mizri)" (see DU-Teššup)
See also
DU-Teššup
References
Moran, William L., The Amarna Letters, Ed. and translated, French, and English, c. 1987, 1992. (softcover, )
Amarna letters officials |
https://en.wikipedia.org/wiki/Sinop%20Airport | Sinop Airport is an airport in Sinop, in the Black Sea Region of Turkey. Turkish Airlines has daily flights from Istanbul. Tower and approach frequency is 126.300 MHz. The old runway of the airport was previously used by the US military base in Sinop. The IATA code has changed from SIC to NOP.
Airlines and destinations
Traffic Statistics
References
External links
Sinop
Airports in Turkey
Buildings and structures in Sinop Province
Transport in Sinop Province |
https://en.wikipedia.org/wiki/Irrintzi | Irrintzi is an armed Basque nationalist group or cell that acts in the Northern Basque Country (Basque: Iparralde). The word irrintzi refers originally to the traditional Basque folk high-pitched scream used to express celebration or happiness.
The first known action of Irrintzi was sabotage in 2006 around Bayonne (including a bomb against the summer house of the French Minister of the Interior Michèle Alliot-Marie). Since then, the organization has attacked railroads, tourist sites, and political party headquarters, mainly by bomb. The Monégasque chef Alain Ducasse, with a restaurant near Biarritz, was accused by Irrintzi of being a speculator and of "folklorising" the Basque Country, and was forced to leave the Basque Country due to the constant attacks that his restaurant suffered. Their declarations are usually closed by the slogan "Euskal Herria ez da salgai" (The Basque Country is not for sale). This calling card was found in more than 30 attacks against tourist targets during 2007.
References
External links
Irrintzi´s declaration of April 19th
Irrintzi´s second declaration of April 19th
Basque politics
Politics of France
Clandestine groups
Paramilitary organizations based in France
Northern Basque Country |
https://en.wikipedia.org/wiki/Downhole%20safety%20valve | A downhole safety valve refers to a component on an oil and gas well, which acts as a failsafe to prevent the uncontrolled release of reservoir fluids in the event of a worst-case-scenario surface disaster. It is almost always installed as a vital component on the completion.
Operation
These valves are commonly uni-directional flapper valves which open downwards such that the flow of wellbore fluids tries to push it shut, while pressure from the surface pushes it open. This means that when closed, it will isolate the reservoir fluids from the surface.
Most downhole safety valves are controlled hydraulically from the surface, meaning they are opened using a hydraulic connection linked directly to a well control panel. When hydraulic pressure is applied down a control line, the hydraulic pressure forces a sleeve within the valve to slide downwards. This movement compresses a large spring and pushes the flapper downwards to open the valve. When hydraulic pressure is removed, the spring pushes the sleeve back up and causes the flapper to shut. In this way, it is failsafe and will isolate the wellbore in the event of a loss of the wellhead. The full designation for a typical valve is 'tubing retrievable, surface controlled, subsurface safety valve', abbreviated to TR-SCSSV.
Positioning
The location of the downhole safety valve within the completion is a precisely determined parameter intended to optimise safety. There are arguments against it either being too high or t |
https://en.wikipedia.org/wiki/Neoschizomer | Neoschizomers are restriction enzymes that recognize the same nucleotide sequence as their prototype but cleave at a different site. In some special applications this is a very helpful feature.
For example:Prototype MaeII A^CGT produces DNA fragments with a 2-base 5' extension
Neoschizomer TaiI ACGT^ produces DNA fragments with a 4-base 3' extension
Prototype ApaI GGGCC^C produces DNA fragments with a 4-base 3' extension
Neoschizomer Bsp120I G^GGCCC produces DNA fragments with a 4-base 5' extension
There are also other pairs of neoschizomers.
Neoschizomers are a subset of isoschizomers.
References
Rebase restriction enzyme database, http://rebase.neb.com/rebase/
See also
Restriction enzymes
pl:Izoschizomery |
https://en.wikipedia.org/wiki/Neato | Neato may refer to:
Neato (spider), a genus of spider
The command line tool, part of the Graphviz software package
Neato Robotics, manufacturer of robotic vacuum cleaners
Northeast Asia Treaty Organization, the proposed military alliance organization |
https://en.wikipedia.org/wiki/Markovian%20arrival%20process | In queueing theory, a discipline within the mathematical theory of probability, a Markovian arrival process (MAP or MArP) is a mathematical model for the time between job arrivals to a system. The simplest such process is a Poisson process where the time between each arrival is exponentially distributed.
The processes were first suggested by Marcel F. Neuts in 1979.
Definition
A Markov arrival process is defined by two matrices, D0 and D1 where elements of D0 represent hidden transitions and elements of D1 observable transitions. The block matrix Q below is a transition rate matrix for a continuous-time Markov chain.
The simplest example is a Poisson process where D0 = −λ and D1 = λ where there is only one possible transition, it is observable, and occurs at rate λ. For Q to be a valid transition rate matrix, the following restrictions apply to the Di
Special cases
Phase-type renewal process
The phase-type renewal process is a Markov arrival process with phase-type distributed sojourn between arrivals. For example, if an arrival process has an interarrival time distribution PH with an exit vector denoted , the arrival process has generator matrix,
Generalizations
Batch Markov arrival process
The batch Markovian arrival process (BMAP) is a generalisation of the Markovian arrival process by allowing more than one arrival at a time. The homogeneous case has rate matrix,
An arrival of size occurs every time a transition occurs in the sub-matrix . Sub-matrices have e |
https://en.wikipedia.org/wiki/Radicicol | Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Biosynthesis
Biosynthesis of Radicicol has been best studied in Pochonia chlamydosporia, in which the majority of the core structure is produced in vivo through iterative type I polyketide synthases. This structure produced is the earliest intermediate in the radicicol biosynthesis, monocillin II. This intermediate is transformed to radicicol through halogenation and epoxide formation performed by RadH and RadP respectively. These enzymes are coded by the genes Rdc2 and Rdc4 in the pathway, and removing either of these results in a product that has the monocillin II core, but does not have either the epoxide or halogen added.
See also
Geldanamycin
References
Further reading
Review of the chemistry and biology of resorcylic acid lactones, including radicicol.
Epoxides
Macrolides
Halogen-containing natural products
Polyketides
Chloroarenes |
https://en.wikipedia.org/wiki/Hardmask | A hardmask is a material used in semiconductor processing as an etch mask instead of a polymer or other organic "soft" resist material.
Hardmasks are necessary when the material being etched is itself an organic polymer. Anything used to etch this material will also etch the photoresist being used to define its patterning since that is also an organic polymer. This arises, for instance, in the patterning of low-κ dielectric insulation layers used in VLSI fabrication. Polymers tend to be etched easily by oxygen, fluorine, chlorine and other reactive gases used in plasma etching.
Use of a hardmask involves an additional deposition process, and hence additional cost. First, the hardmask material is deposited and etched into the required pattern using a standard photoresist process. Following that the underlying material can be etched through the hardmask. Finally the hardmask is removed with a further etching process.
Hardmask materials can be metal or dielectric. Silicon based masks such as silicon dioxide or silicon carbide are usually used for etching low-κ dielectrics. However, SiOCH (carbon doped hydrogenated silicon oxide), a material used to insulate copper interconnects, requires an etchant that attacks silicon compounds. For this material, metal or amorphous carbon hardmasks are used. The most common metal for hardmasks is titanium nitride, but tantalum nitride has also been used.
References
Bibliography
Shi, Hualing; Shamiryan, Denis; de Marneffe, Jea |
https://en.wikipedia.org/wiki/Lipiduria | Lipiduria or lipuria is the presence of lipids in the urine. Lipiduria is most frequently observed in nephrotic syndrome where it is passed as lipoproteins along with other proteins. It has also been reported as a sign following fat embolism.
When lipiduria occurs, epithelial cells or macrophages contain endogenous fats. When filled with numerous fat droplets, such cells are called oval fat bodies. Oval fat bodies exhibit a "Maltese cross" configuration under polarized light microscopy. The Maltese cross appearance occurs because of its liquid-crystalline structure giving it a double refraction (birefringence).
See also
Urostealith
References
Urine |
https://en.wikipedia.org/wiki/CD58 | CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
CD58 binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion and recognition between the T cells and Professional Antigen Presenting Cells, facilitating signal transduction necessary for an immune response. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis. Genomic region containing the single-nucleotide polymorphism rs1335532, associated with high risk of multiple sclerosis, has enhancer properties and can significantly boost the CD58 promoter activity in lymphoblast cells. The protective (C) rs1335532 allele creates functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway.
CD58 plays a role in the regulation of colorectal tumor-initiating cells (CT-ICs). Thus, cells that express CD58 have become a cell of interest in tumorigenesis. Mutations of CD58 have been linked to immune evasion observed in some lymphomas and studies are underway to analyze how its involvement directly affects classical Hodgkin lymphoma (cHL).
Introduct |
https://en.wikipedia.org/wiki/Sphingomonas%20paucimobilis | Sphingomonas paucimobilis is a strictly aerobic Gram-negative bacterium that has a single polar flagellum with slow motility. The cell size is around 0.7 x 1.4 μm. It is usually found in soil. As with the other members of the genus, its biochemistry is remarkable in possession of ubiquinone 10 as its major respiratory quinone, and of glycosphingolipids instead of lipopolysaccharides in its cell envelope. It has been implicated in various types of clinical infections.
S. paucimobilis is able to degrade lignin-related biphenyl chemical compounds.
References
External links
Type strain of Sphingomonas paucimobilis at BacDive - the Bacterial Diversity Metadatabase
paucimobilis
Bacteria described in 1977 |
https://en.wikipedia.org/wiki/Medical%20University%20of%20Varna | The Medical University of Varna (MU-Varna) is a Bulgarian state school for higher education dedicated to training specialists in the fields of medicine and healthcare who graduate with the educational and qualification degrees of Master, Bachelor and Professional Bachelor. The university has a legal entity status with the following scope of business activities: training of cadres and professional qualification; training of PhD students; postgraduate education for medical and non-medical cadres; conducting medical diagnosis, prevention, consultation, rehabilitation, and expert services at the university hospitals; scientific research and applied sciences; international cooperation in the field of education and science; administrative, social, sport, publishing, information, and other activities.
The Medical University of Varna is the first university in Bulgaria to implement the EFQM® model for Business Excellence of the European Foundation for Quality Management in 2008. The diplomas issued by the university are recognised in all the European Union countries.
MU-Varna possesses academic autonomy.
History
Foundation
The university was founded as a higher medical institute by a Decree No. 414 from November 12, 1960, of the Presidium of the National Assembly of the Republic of Bulgaria and Order No. 208 from January 19, 1961, of the Ministry of Health. October 1, 1961 is considered its birthdate – the first school day of the first academic year at the first higher education |
https://en.wikipedia.org/wiki/Lie%27s%20third%20theorem | In the mathematics of Lie theory, Lie's third theorem states that every finite-dimensional Lie algebra over the real numbers is associated to a Lie group . The theorem is part of the Lie group–Lie algebra correspondence.
Historically, the third theorem referred to a different but related result. The two preceding theorems of Sophus Lie, restated in modern language, relate to the infinitesimal transformations of a group action on a smooth manifold. The third theorem on the list stated the Jacobi identity for the infinitesimal transformations of a local Lie group. Conversely, in the presence of a Lie algebra of vector fields, integration gives a local Lie group action. The result now known as the third theorem provides an intrinsic and global converse to the original theorem.
Historical notes
The equivalence between the category of simply connected real Lie groups and finite-dimensional real Lie algebras is usually called (in the literature of the second half of 20th century) Cartan's or the Cartan-Lie theorem as it was proved by Élie Cartan. Sophus Lie had previously proved the infinitesimal version: local solvability of the Maurer-Cartan equation, or the equivalence between the category of finite-dimensional Lie algebras and the category of local Lie groups.
Lie listed his results as three direct and three converse theorems. The infinitesimal variant of Cartan's theorem was essentially Lie's third converse theorem. In an influential book Jean-Pierre Serre called it the t |
https://en.wikipedia.org/wiki/Burkholderia%20glumae | Burkholderia glumae is a Gram-negative, soil-borne, betaproteobacterium.
Genome
Of all bacteria with the necessary sequence data available, B. glumae has the highest number of prophages (bacteriophages integrated into its genome).
References
External links
Louisiana Agriculture, Summer 2011, Vol. 54, pp. 16/17
Texas Rice, September 2010, Vol. X, pp. 3/8
Type strain of Burkholderia glumae at BacDive - the Bacterial Diversity Metadatabase
Burkholderiaceae
Bacterial plant pathogens and diseases
Rice diseases
Bacteria described in 1994 |
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