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https://en.wikipedia.org/wiki/Methylglutaconyl-CoA%20hydratase | 3-Methylglutaconyl-CoA hydratase, also known as MG-CoA hydratase and AUH, is an enzyme () encoded by the AUH gene on chromosome 19. It is a member of the enoyl-CoA hydratase/isomerase superfamily, but it is the only member of that family that is able to bind to RNA. Not only does it bind to RNA, AUH has also been observed to be involved in the metabolic enzymatic activity, making it a dual-role protein. Mutations of this gene have been found to cause a disease called 3-Methylglutaconic Acuduria Type 1.
Structure
The enzyme AUH has a molecular mass of 32 kDa and the AUH gene consists of 18 exons, is 1.7 kb long, and is mainly found in kidney, skeletal muscle, heart, liver, and spleen cells. AUH has a similar fold that is found in other members of the enoyl-CoA hydratase/isomerase family; however, it is a hexamer as a dimer of trimers. Also unlike other members of its family, AUH's surface is positively charged in contrast to the negative charge seen on that of other classes. Between the two trimers of the enzyme, wide clefts were seen with a highly positive charge and lysine residues in alpha helix H1. These lysine residues were shown to be the main reason why AUH is able to bind to RNA rather than its counterparts. Moreover, it has been found that the oligomeric state of AUH depends on whether or not RNA is present. If RNA is near, the AUH will take on an asymmetric shape that loses the 3- and 2-fold crystallographic rotation axes, because of realignment of the internal 3-f |
https://en.wikipedia.org/wiki/Crystal%20Mangum | Crystal Gail Mangum (born July 18, 1978) is an American former exotic dancer and convicted murderer from Durham, North Carolina who is best known for having made false allegations of rape against lacrosse players in the 2006 Duke lacrosse case. The fact that Mangum was a black woman working in the sex industry, while the accused were all white men, created extensive media interest and academic debate about race, class, gender and the politicization of the justice system.
In February 2010, she was arrested on charges of attempted murder of her live-in partner, Milton Walker. She was eventually convicted of contributing to the delinquency of a juvenile, injury to personal property and resisting a public officer.
In November 2013, she was found guilty of second-degree murder after she stabbed boyfriend Reginald Daye, who died 10 days after. She argued that she acted in self-defense, fearing that Daye would kill her. She was sentenced to 14 to 18 years in prison.
Early life
Mangum was born and grew up in Durham, North Carolina, the daughter of Travis Mangum, a truck driver, and his wife Mary. She was the youngest of three children. She attended Hillside High School, graduating in 1996.
In 1996, Mangum filed a police report alleging that three years earlier, when she was 14, she had been kidnapped by three assailants, driven to Creedmoor, North Carolina, and raped. One of those she accused was her boyfriend, who was 21 at the time, which would constitute statutory rape. She s |
https://en.wikipedia.org/wiki/University%20Rover%20Challenge | The University Rover Challenge (URC) by the Mars Society is a robotics competition for university level students that challenges teams to design and build a rover that would be of use to early explorers on Mars. The competition is held annually at the Mars Desert Research Station, outside Hanksville, Utah in the United States. The site was selected by the Mars Society for its geographic similarity to Mars: In addition to being a largely barren desert area, the soil in the area has a chemical composition similar to Martian soil. The competition has also expanded internationally to include the European Rover Challenge, Canadian International Rover Challenge, and the Indian Rover Challenge as part of the Rover Challenge Series.
The aim of the University Rover Challenge is to encourage students to develop skills in robotics, improve the state-of-the-art in rovers, and work in multi-disciplinary teams with collaboration between scientists and engineers. The competition was launched in 2006 with competitions held annually every summer since 2007.
History
Inception
The URC was first established in 2006 with the goal of promoting STEM education and inspiring the next generation of space explorers. Since its inception, the competition has grown in scale and significance, attracting teams from universities and institutions worldwide.
The idea behind the URC's creation is that the kinds of rovers teams are building would assist astronauts in the field, controlled remotely by anoth |
https://en.wikipedia.org/wiki/Edmonds%27%20algorithm | In graph theory, Edmonds' algorithm or Chu–Liu/Edmonds' algorithm is an algorithm for finding a spanning arborescence of minimum weight (sometimes called an optimum branching).
It is the directed analog of the minimum spanning tree problem.
The algorithm was proposed independently first by Yoeng-Jin Chu and Tseng-Hong Liu (1965) and then by Jack Edmonds (1967).
Algorithm
Description
The algorithm takes as input a directed graph where is the set of nodes and is the set of directed edges, a distinguished vertex called the root, and a real-valued weight for each edge .
It returns a spanning arborescence rooted at of minimum weight, where the weight of an arborescence is defined to be the sum of its edge weights, .
The algorithm has a recursive description.
Let denote the function which returns a spanning arborescence rooted at of minimum weight.
We first remove any edge from whose destination is .
We may also replace any set of parallel edges (edges between the same pair of vertices in the same direction) by a single edge with weight equal to the minimum of the weights of these parallel edges.
Now, for each node other than the root, find the edge incoming to of lowest weight (with ties broken arbitrarily).
Denote the source of this edge by .
If the set of edges does not contain any cycles, then .
Otherwise, contains at least one cycle.
Arbitrarily choose one of these cycles and call it .
We now define a new weighted directed graph in which the cycle is "cont |
https://en.wikipedia.org/wiki/Dionysios%20of%20Fourna | Dionysius of Fourna (; c. 1670 – after 1744) was an author, educator, painter, and monk. He was one of the most influential painters of the 18th century. He was a monk on the isolated self-autonomous monastery of Mount Athos. He was a self-taught painter. He was exposed to the works of the Cretan School and Heptanese School but choose to paint in the traditional style. His works are a mixture of different styles including the palaeologan renaissance. He was active from 1685 to 1744. According to the Hellenic Institute, two of his fresco and ten of his icons have survived. He was active while the Heptanese School flourished. His contemporary at the time was the painter David both artists belong to a class of their own.
His student and coworker was famous Greek painter Kyrillos Foteinos. He was from Chios. Some of his other students were Zacharias Vakos, Agapios and two painters known as Petros. Dionysios was also the author of a famous manual on painting.
Biography
He was born in Fourna, Greece was still part of the Ottoman Empire. His father was a priest named Panagiotis. Dionysio's most incredible characteristic was that he was a self-taught painter. He rejected the art of the Cretan School and the Heptanese School but was exposed to the work while he was on Mount Athos. He preferred the work of Manuel Panselinos. He was considered a traditionalist.
He painted several icons in Mount Athos, although the dates are indistinct (either 1701 or 1711) and |
https://en.wikipedia.org/wiki/Microsphaera%20penicillata | Microsphaera penicillata is a plant pathogen that causes powdery mildew on sycamore.
It also affects certain species of Corylus including Corylus sieboldiana, Corylus colurna and Corylus heterophylla.
References
External links
Index Fungorum
USDA ARS Fungal Database
Fungal tree pathogens and diseases
Microsphaera
Fungi described in 1815 |
https://en.wikipedia.org/wiki/N%27-Formylkynurenine | {{DISPLAYTITLE:N-Formylkynurenine}}-Formylkynurenine''' is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of ''-formylkynurenine is catalyzed by heme dioxygenases.
See also
Indoleamine 2,3-dioxygenase
References
Alpha-Amino acids
Formamides |
https://en.wikipedia.org/wiki/Polariton%20superfluid | Polariton superfluid is predicted to be a state of the exciton-polaritons system that combines the characteristics of lasers with those of excellent electrical conductors. Researchers look for this state in a solid state optical microcavity coupled with quantum well excitons. The idea is to create an ensemble of particles known as exciton-polaritons and trap them.
Wave behavior in this state results in a light beam similar to that from a laser but possibly more energy efficient.
Unlike traditional superfluids that need temperatures of approximately ~4 K, the polariton superfluid could in principle be stable at much higher temperatures, and might soon be demonstrable at room temperature. Evidence for polariton superfluidity was reported in by Alberto Amo and coworkers, based on the suppressed scattering of the polaritons during their motion.
Although several other researchers are working in the same field, the terminology and conclusions are not completely shared by the different groups. In particular, important properties of superfluids, such as zero viscosity, and of lasers, such as perfect optical coherence, are a matter of debate. Although, there is clear indication of quantized vortices when the pump beam has orbital angular momentum.
Furthermore, clear evidence has been demonstrated also for superfluid motion of polaritons, in terms of the Landau criterion and the suppression of scattering from defects when the flow velocity is slower than the speed of sound in the flu |
https://en.wikipedia.org/wiki/Hamudi%20Brick | Mohamad "Hamoudi" Brik (, ; born March 19, 1978) is a former Arab-Israeli footballer.
External links
Profile and statistics of Hamudi Brick on One.co.il
1978 births
Living people
Arab citizens of Israel
Arab-Israeli footballers
Israeli Muslims
Israeli men's footballers
Maccabi Kafr Kanna F.C. players
Maccabi Netanya F.C. players
Bnei Sakhnin F.C. players
Hapoel Acre F.C. players
Ahva Arraba F.C. players
Liga Leumit players
Israeli Premier League players
Men's association football defenders |
https://en.wikipedia.org/wiki/Burstsort | Burstsort and its variants are cache-efficient algorithms for sorting strings. They are variants of the traditional radix sort but faster for large data sets of common strings, first published in 2003, with some optimizing versions published in later years.
Burstsort algorithms use a trie to store prefixes of strings, with growable arrays of pointers as end nodes containing sorted, unique, suffixes (referred to as buckets). Some variants copy the string tails into the buckets. As the buckets grow beyond a predetermined threshold, the buckets are "burst" into tries, giving the sort its name. A more recent variant uses a bucket index with smaller sub-buckets to reduce memory usage. Most implementations delegate to multikey quicksort, an extension of three-way radix quicksort, to sort the contents of the buckets. By dividing the input into buckets with common prefixes, the sorting can be done in a cache-efficient manner.
Burstsort was introduced as a sort that is similar to MSD radix sort, but is faster due to being aware of caching and related radixes being stored closer to each other due to specifics of trie structure. It exploits specifics of strings that are usually encountered in real world. And although asymptotically it is the same as radix sort, with time complexity of (w – word length and n – number of strings to be sorted), but due to better memory distribution it tends to be twice as fast on big data sets of strings. It has been billed as the "fastest known algor |
https://en.wikipedia.org/wiki/Cell%20lists | Cell lists (also sometimes referred to as cell linked-lists) is a data structure in molecular dynamics simulations to find all atom pairs within a given cut-off distance of each other. These pairs are needed to compute the short-range non-bonded interactions in a system, such as Van der Waals forces or the short-range part of the electrostatic interaction when using Ewald summation.
Algorithm
Cell lists work by subdividing the simulation domain into cells with an edge length greater than or equal to the cut-off radius of the interaction to be computed. The particles are sorted into these cells and the interactions are computed between particles in the same or neighbouring cells.
In its most basic form, the non-bonded interactions for a cut-off distance are computed as follows:
for all neighbouring cell pairs do
for all do
for all do
if then
Compute the interaction between and .
end if
end for
end for
end for
Since the cell length is at least in all dimensions, no particles within of each other can be missed.
Given a simulation with particles with a homogeneous particle density, the number of cells is proportional to and inversely proportional to the cut-off radius (i.e. if increases, so does the number of cells). The average number of particles per cell therefore does not depend on the total number of particles. The cost of interacting two cells is in . The number of cell pairs is proportional to the number of cells which is again proportional to the numbe |
https://en.wikipedia.org/wiki/Probabilistic%20automaton | In mathematics and computer science, the probabilistic automaton (PA) is a generalization of the nondeterministic finite automaton; it includes the probability of a given transition into the transition function, turning it into a transition matrix. Thus, the probabilistic automaton also generalizes the concepts of a Markov chain and of a subshift of finite type. The languages recognized by probabilistic automata are called stochastic languages; these include the regular languages as a subset. The number of stochastic languages is uncountable.
The concept was introduced by Michael O. Rabin in 1963; a certain special case is sometimes known as the Rabin automaton (not to be confused with the subclass of ω-automata also referred to as Rabin automata). In recent years, a variant has been formulated in terms of quantum probabilities, the quantum finite automaton.
Informal Description
For a given initial state and input character, a deterministic finite automaton (DFA) has exactly one next state, and a nondeterministic finite automaton (NFA) has a set of next states. A probabilistic automaton (PA) instead has a weighted set (or vector) of next states, where the weights must sum to 1 and therefore can be interpreted as probabilities (making it a stochastic vector). The notions states and acceptance must also be modified to reflect the introduction of these weights. The state of the machine as a given step must now also be represented by a stochastic vector of states, and a state a |
https://en.wikipedia.org/wiki/Citrin | Citrin, also known as solute carrier family 25, member 13 (citrin) or SLC25A13, is a protein which in humans is encoded by the SLC25A13 gene.
Citrin is associated with type II citrullinemia and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD).
Function
Citrin (74 kDa) is a dimeric calcium-activated glutamate/aspartate carrier found in the mitochondrial membrane of mammals. Citrin is one of two isoforms of these mitochondrial calcium-activated glutamate/aspartate carriers found in humans and is predominately expressed in non-excitable tissues.
Upon binding calcium, citrin catalyzes the transport of glutamate and a proton into the mitochondrial matrix in exchange for aspartate transport to the cytosol. Upon being transported by citrin from the mitochondrial matrix to the cytosol, aspartate is converted into oxaloacetate, and then into malate, which is then transported back into the matrix by means of the malate-aspartate shuttle. Upon entering the mitochondrial matrix, malate is converted back into oxaloacetate to participate in the citric acid cycle. Citrin is also important because it supplies liver cells with aspartate that is used during the urea cycle and gluconeogenesis.
Structure
The citrin monomer peptide has a three-domain structure, consisting of an N-terminal domain, a carrier domain, and a C-terminal domain. The N-terminal domain contains eight EF-hand motifs and is responsible for the binding of a single calcium ion. The N-terminal domain |
https://en.wikipedia.org/wiki/Endothelial%20progenitor%20cell | Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the regeneration of the endothelial lining of blood vessels. Outgrowth endothelial cells are an EPC subtype committed to endothelial cell formation. Despite the history and controversy, the EPC in all its forms remains a promising target of regenerative medicine research.
History and controversy
Developmentally, the endothelium arises in close contact with the hematopoietic system. This, and the existence of hemogenic endothelium, led to a belief and search for adult hemangioblast- or angioblast-like cells; cells which could give rise to functional vasculature in adults. The existence of endothelial progenitor cells has been posited since the mid-twentieth century, however their existence was not confirmed until the 1990s when Asahara et al. published the discovery of the first putative EPC.
Recently, controversy has developed over the definition of true endothelial progenitors. Although bone marrow-derived cells do appear to localize to injured vessels and promote an angiogenic switch, other studies have suggested these cells do not contribute directly to the functional endothelium, instead acting via paracrine methods to provide support for the resident endothelial cells. While some other authors have contested these, and maintained that they are true EPCs, many investigators have begun to term these cells colony forming unit-Hill cells (CFU-Hill) or ci |
https://en.wikipedia.org/wiki/Lema%C3%AEtre%E2%80%93Tolman%20metric | In physics, the Lemaître–Tolman metric, also known as the Lemaître–Tolman–Bondi metric or the Tolman metric, is a Lorentzian metric based on an exact solution of Einstein's field equations; it describes an isotropic and expanding (or contracting) universe which is not homogeneous, and is thus used in cosmology as an alternative to the standard Friedmann–Lemaître–Robertson–Walker metric to model the expansion of the universe. It has also been used to model a universe which has a fractal distribution of matter to explain the accelerating expansion of the universe. It was first found by Georges Lemaître in 1933 and Richard Tolman in 1934 and later investigated by Hermann Bondi in 1947.
Details
In a synchronous reference system where and , the time coordinate (we set ) is also the proper time and clocks at all points can be synchronized. For a dust-like medium where the pressure is zero, dust particles move freely i.e., along the geodesics and thus the synchronous frame is also a comoving frame wherein the components of four velocity are . The solution of the field equations yield
where is the radius or luminosity distance in the sense that the surface area of a sphere with radius is and is just interpreted as the Lagrangian coordinate and
subjected to the conditions and , where and are arbitrary functions and is the matter density. We can also assume and that excludes cases resulting in crossing of material particles during its motion. To each particle there |
https://en.wikipedia.org/wiki/Amaro%20Averna | Amaro Averna is an Italian liqueur in the Amaro category produced in Caltanissetta, Sicily. It is named after its inventor, Salvatore Averna, who invented the recipe in 1868. This drink is produced on the Island of Sicily and is considered a traditional drink.
The Averna company was acquired in 2014 by Gruppo Campari.
History
In 1802, Salvatore Averna. was born into a family of drapers. Growing up in Caltanissetta, he became one of the most active members of the community, a justice of the peace and benefactor of the Abbey of the Holy Spirit. Here, following an ancient tradition born in the fortified Benedictine abbeys and spread to Europe through the Cluniac and Cistercian monasteries, the monks produced an elixir of herbs that was pleasant despite being "bitter", and was popularly thought to possess tonic and therapeutic properties. In 1859, as a token of gratitude, fray Girolamo, prior de la Abadía de Santo Spirito gave Salvatore the recipe for the infusion. In 1868 he began producing Averna for guests at his home.
It was Francesco Averna, son of Salvatore, who took the initiative to promote the bitter, participating in various exhibitions in Italy and abroad. During a private visit of King Umberto I in 1895, Francesco received a gold pin with the House of Savoy insignia in recognition of the Sicilian bitter, which by now was well known. In 1912 Vittorio Emanuele III granted the Averna Company the right to affix the royal crest on the label of their liquor with the w |
https://en.wikipedia.org/wiki/Adaptor%20hypothesis | The adaptor hypothesis is a theoretical scheme in molecular biology to explain how information encoded in the nucleic acid sequences of messenger RNA (mRNA) is used to specify the amino acids that make up proteins during the process of translation. It was formulated by Francis Crick in 1955 in an informal publication of the RNA Tie Club, and later elaborated in 1957 along with the central dogma of molecular biology and the sequence hypothesis. It was formally published as an article "On protein synthesis" in 1958. The name "adaptor hypothesis" was given by Sydney Brenner.
Crick postulated that there must exist a small molecule to precisely recognise and bind the mRNA sequences while amino acids are being synthesised. The hypothetical adaptor molecule was later established to be a hitherto unknown nucleic acid, transfer RNA (tRNA).
Development
In 1953, English biophysicist Francis Crick and American biologist James Watson, working together at the Cavendish Laboratory of the University of Cambridge, worked out the correct description of the structure of DNA, one of the major genetic materials. In their follow-up paper the same year, they introduced the concept of genetic information alongside the notion that DNA and protein cloud be related. By 1954, it was becoming to be understood that DNA, RNA (only messenger RNA was understood at the time, but only as a vague nucleic acid, and identified as such only in 1960) and proteins were related as components of the same genetic in |
https://en.wikipedia.org/wiki/%C3%96rjan%20Ouchterlony | Örjan Thomas Ouchterlony (January 14, 1914, Stockholm – September 25, 2004) was a Swedish bacteriologist and immunologist who is credited with the creation of the Ouchterlony double immuno diffusion test in the 1940s. He was trained at Karolinska Institute, where his received his medical doctorate. He worked at Sweden's State Bacteriology Laboratory from 1935 to 1952. Ouchterlony was a professor of bacteriology at the Medical Faculty of Gothenburg University from 1952 to 1980 and was elected a member of the Royal Swedish Academy of Sciences in 1968. In addition to his laboratory work, he did research in field epidemiology of infectious diseases and worked and lectured in Africa and the United States, as well as in several countries in Europe. Upon his retirement in 1980, the successor to his professorial chair was Jan Holmgren.
Important works
References
Swedish bacteriologists
Swedish immunologists
Academic staff of the University of Gothenburg
Karolinska Institute alumni
Members of the Royal Swedish Academy of Sciences
1914 births
2004 deaths |
https://en.wikipedia.org/wiki/Immunodiffusion | Immunodiffusion is a diagnostic test which involves diffusion through a substance such as agar which is generally soft gel agar (2%) or agarose (2%), used for the detection of antibodies or antigen.
The commonly known types are:
Single diffusion in one dimension (Oudin procedure)
Double diffusion in one dimension (Oakley Fulthorpe procedure)
Single diffusion in two dimensions (radial immunodiffusion or Mancini method)
Double diffusion in two dimensions (Ouchterlony double immunodiffusion)
Notes
External links
Biological techniques and tools
Diagnostic virology
Immunologic tests |
https://en.wikipedia.org/wiki/Tetrahalomethane | Tetrahalomethanes are fully halogenated methane derivatives of general formula CFkCllBrmInAtp, where:Tetrahalomethanes are on the border of inorganic and organic chemistry, thus they can be assigned both inorganic and organic names by IUPAC: tetrafluoromethane - carbon tetrafluoride, tetraiodomethane - carbon tetraiodide, dichlorodifluoromethane - carbon dichloride difluoride.
Each halogen (F, Cl, Br, I, At) forms a corresponding halomethane, but their stability decreases in order CF4 >
CCl4 > CBr4 > CI4 from exceptionally stable gaseous tetrafluoromethane with bond energy 515 kJ·mol−1 to solid tetraiodomethane, depending on bond energy.
Many mixed halomethanes are also known, such as CBrClF2.
Uses
Fluorine, chlorine, and sometimes bromine-substituted halomethanes were used as refrigerants, commonly known as CFCs (chlorofluorocarbons).
See also
Monohalomethane
Dihalomethane
Trihalomethane
Inorganic carbon compounds
Nonmetal halides |
https://en.wikipedia.org/wiki/Scotland%20national%20football%20team%20records%20and%20statistics | This page details Scotland national football team records and statistics; the most capped players, the players with the most goals, and Scotland's match record by opponent and decade.
Player records
Most capped players
Players in bold are still active with Scotland.
Top goalscorers
Players in bold are still active with Scotland.
Hat-tricks
Table
Wartime internationals, not regarded as official matches, are not included in the list.
Team records
Head to head records
Statistics include official FIFA recognised matches, five matches from a 1967 overseas tour that were reclassified as full internationals in 2021, and a match against a Hong Kong League XI played on 23 May 2002 that the Scottish Football Association includes in its statistical totals.
By period
Statistics include official FIFA recognised matches, five matches from a 1967 overseas tour that were reclassified as full internationals in 2021, and a match against a Hong Kong League XI played on 23 May 2002 that the Scottish Football Association includes in its statistical totals.
Notes
References
National association football team records and statistics |
https://en.wikipedia.org/wiki/Industrial | Industrial may refer to:
Industry
Industrial archaeology, the study of the history of the industry
Industrial engineering, engineering dealing with the optimization of complex industrial processes or systems
Industrial city, a city dominated by one or more industries
Industrial loan company, a financial institution in the United States that lends money, and may be owned by non-financial institutions
Industrial organization, a field that builds on the theory of the firm by examining the structure and boundaries between firms and markets
Industrial Revolution, the development of industry in the 18th and 19th centuries
Industrial society, a society that has undergone industrialization
Industrial technology, a broad field that includes designing, building, optimizing, managing and operating industrial equipment, and predesignated as acceptable for industrial uses, like factories
Industrial video, a video that targets “industry” as its primary audience
Industrialization, the societal process and period of developing such technology and transforming into such societies
Arts and entertainment
Music
Industrial (album), debut album by Pitchshifter
Industrial music, the genre of music that draws on transgressive and provocative themes
Industrial dance, a subgenre characterized by electronic beats, symphonic keyboard lines, pile-driver rhythms, angst-ridden or sampled vocals, and cyberpunk imagery
Industrial metal, a fusion genre characterized by repeating metal guitar |
https://en.wikipedia.org/wiki/Wolf%20attack | Wolf attacks are injuries to humans or their property by any subspecies of wolf. Their frequency varies with geographical location and historical period, but overall gray wolf attacks are rare. Wolves today tend to live mostly far from people or have developed the tendency and ability to avoid them. The country with the most extensive historical records is France, where nearly 7,600 fatal attacks were documented from 1200 to 1920. There are few historical records or modern cases of wolf attacks in North America. In the half-century up to 2002, there were eight fatal attacks in Europe and Russia, three in North America, and more than 200 in south Asia. Experts categorize wolf attacks into various types, including rabies-infected, predatory, agonistic, and defensive.
The gray wolf is the largest wild member of the canid family, with males averaging , and females . It is the most specialized member of its genus in the direction of carnivory and hunting large game.
Wolf–human interactions
Although they primarily target ungulates, wolves are at times versatile in their diet; for example, those in the Mediterranean region largely subsist on garbage and domestic animals. They have powerful jaws and teeth and powerful bodies capable of great endurance, and often run in large packs. Nevertheless, they tend to fear and avoid human beings, especially in North America.
Wolves vary in temperament and their reaction to humans. Those with little prior experience with humans, and those p |
https://en.wikipedia.org/wiki/Glycerite | A traditional glycerite is a fluid extract of an herb or other medicinal substance made using glycerin as the majority of the fluid extraction medium.
Definition
According to King's American Dispensatory (1898), glycerite is:Glycerita.—Glycerites.
By this class of preparations is generally understood solutions of medicinal substances in glycerin, although in certain instances the various Pharmacopoeias deviate to an extent. The term Glycerita as here applied to fluid glycerines, or solutions of agents in glycerin, is preferable to the ordinary names, "glyceroles," "glycerates," or "glycemates," etc., and includes all fluid preparations of the kind referred to, whether for internal administration or local application.
Glycerites may consist of either vegetable source glycerin, animal source glycerin or a combination of the two. In the case of liquid herbal products (a segment of the dietary supplements industry), the general rule is to utilize vegetable glycerin only, while nutraceuticals (another segment of the dietary supplements industry) might use a combination of both vegetable and animal source derived glycerin.
Alcohol-free (as opposed to alcohol-removed) glycerite products, in which alcohol is never used or added at any time, are preferred by those desiring or requiring that no alcohol be used in making products or added thereafter. The reasons are typically for personal or religious beliefs.
Muslims for instance, represent the largest population requiring an |
https://en.wikipedia.org/wiki/Sphingomonas%20abikonensis | Sphingomonas abikonensis is a species of Gram-negative bacteria. Following 16S rRNA phylogenetic analysis, it was determined that the organism formerly classified as 'P.' abikonensis belonged in the Sphingomonas rRNA lineage. It is capable of forming freshwater biofilms.
References
abikonensis |
https://en.wikipedia.org/wiki/Santenay | Santenay may refer to:
Places
Santenay, Côte-d'Or, France
Santenay, Loir-et-Cher, France
Other uses
Santenay AOC, a wine classification
Ensemble Santenay, a German early music ensemble |
https://en.wikipedia.org/wiki/Nucleotidyltransferase | Nucleotidyltransferases are transferase enzymes of phosphorus-containing groups, e.g., substituents of nucleotidylic acids or simply nucleoside monophosphates. The general reaction of transferring a nucleoside monophosphate moiety from A to B, can be written as:
A-P-N + B A + B-P-N
For example, in the case of polymerases, A is pyrophosphate and B is the nascent polynucleotide.
They are classified under EC number 2.7.7 and they can be categorised into:
Uridylyltransferases, which transfer uridylyl- groups
Adenylyltransferases, which transfer adenylyl- groups
Guanylyltransferases, which transfer guanylyl- groups
Cytitidylyltransferases, which transfer cytidylyl- groups
Thymidylyltransferases, which transfer thymidylyl- groups
Role in metabolism
Many metabolic enzymes are modified by nucleotidyltransferases. The attachment of an AMP (adenylylation) or UMP (uridylylation) can activate or inactivate an enzyme or change its specificity (see figure). These modifications can lead to intricate regulatory networks that can finely tune enzymatic activities so that only the needed compounds are made (here: glutamine).
Role in DNA repair mechanisms
Nucleotidyl transferase is a component of the repair pathway for single nucleotide base excision repair. This repair mechanism begins when a single nucleotide is recognized by DNA glycosylase as incorrectly matched or has been mutated in some way (UV light, chemical mutagen, etc.), and is removed. Later, a nucleotidyl transferase is used |
https://en.wikipedia.org/wiki/Diphosphotransferase | Diphosphotransferase are phosphotransferase enzymes which act upon pyrophosphate groups.
They are classified under EC number 2.7.6.
External links
Enzymes
EC 2.7.6 |
https://en.wikipedia.org/wiki/Thiamine%20transporter%201 | Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene. SLC19A2 is a thiamine transporter. Mutations in this gene cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.
Structure
The SLC19A2 gene is located on the q arm of chromosome 1 in position 24.2 and spans 22,062 base pairs. The gene produces a 55.4 kDa protein composed of 497 amino acids. In the encoded protein (TC1), a multi-pass membrane protein located in the cell membrane, the N-terminus and C-terminus face the cytosol. This gene has 6 exons while the protein has 12 putative transmembrane domains, with 3 phosphorylation sites in putative intracellular domains, 2 N-glycolysation sites in putative extracellular domains, and a 17-amino acid long G protein-coupled receptor signature sequence. The thiamine transporter protein encoded by SLC19A2 has a 40% shared amino acid identity with the folate transporter SLC19A1. The N-terminal domain and the sequence between the C-terminal domain and sixth transmembrane domain are required for proper localization of this protein to the cell membrane.
Function
The encoded protein is a high-affinity transporter specific to the intake of thiamine. Thiamine transport is not inhibited by other organic cations nor affected by sodium ion co |
https://en.wikipedia.org/wiki/Thiamine%20transporter%202 | Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.
Function
ThTr-2 is a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity.
It is specifically inhibited by chloroquine.
Clinical significance
Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.
References
Further reading
External links
Solute carrier family |
https://en.wikipedia.org/wiki/List%20of%20Hull%20City%20A.F.C.%20records%20and%20statistics |
Most league goals
Most goals in a season
Most league appearances
Players
Youngest Player
Matt Edeson, 16 years & 63 days – Hull City vs Fulham – 10 October 1992
Oldest Player
Steve Harper, 40 years & 71 days – Hull City vs Manchester United – 24 May 2015
Oldest goal scorer
Dean Windass, 39 years & 235 days – Hull City v Portsmouth
Results
Biggest Victory
11–1 vs Carlisle United, Division 3, 14 January 1939
In Premier League (home):
6–0 vs Fulham, Premier League, 28 December 2013
In Premier League (away):
4–0 vs Cardiff City, Premier League, 22 February 2014
Biggest Defeat
0–8 vs Wolverhampton Wanderers, Division 2, 4 November 1911
0–8 vs Wigan Athletic, EFL Championship, 14 July 2020
Transfer fees
Paid
£13,000,000 – Ryan Mason from Tottenham Hotspur – 2016
£10,000,000 – Abel Hernández from Palermo – 2014
£8,000,000 (reportedly) – Jake Livermore from Tottenham Hotspur – 2014
£7,000,000 – Robert Snodgrass from Norwich City – 2014
£6,000,000 (reportedly) (rising to £7,000,000) – Shane Long from West Bromwich Albion – 2014 & Nikica Jelavić from Everton – 2014
£5,250,000 (reportedly) – Tom Huddlestone from Tottenham – 2013
£5,000,000 – Jimmy Bullard from Fulham – 2009
£3,500,000 – Stephen Hunt from Reading – 2009 (undisclosed fee reportedly in the region of £3.5 million)
£3,000,000 – Seyi Olofinjana from Stoke City – 2009
£2,600,000 – Nick Proschwitz from Paderborn 07 – 2012 (€3.3 million)
£2,500,000 – Anthony Gardner from Tottenham Hotspur – |
https://en.wikipedia.org/wiki/Glutamate%20formimidoyltransferase | Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions:
5-formimidoyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formimidoyl-L-glutamate
5-formyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formyl-L-glutamate
It is classified under and in mammals is found as part of a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase activity.
Structure
The formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD) forms a homodimer, with each protomer comprising two subdomains. The formiminotransferase domain has an N-terminal subdomain that is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains. In humans, deficiency of this enzyme results in a disease phenotype.
References
External links
Protein domains
EC 2.1.2 |
https://en.wikipedia.org/wiki/Transcription%20factor%20II%20A | Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.
Functions
TFIIA interacts with the TBP subunit of TFIID and aids in the binding of TBP to TATA-box containing promoter DNA. Interaction of TFIIA with TBP facilitates formation of and stabilizes the preinitiation complex. Interaction of TFIIA with TBP also results in the exclusion of negative (repressive) factors that might otherwise bind to TBP and interfere with PIC formation. TFIIA also acts as a coactivator for some transcriptional activators, assisting with their ability to increase, or activate, transcription. The requirement for TFIIA in vitro transcription systems has been variable, and it can be considered either as a GTF and/or a loosely associated TAF-like coactivator. Genetic analysis in yeast has shown that TFIIA is essential for viability.
Structure
TFIIA is a heterodimer with two subunits: one large unprocessed (subunit 1, or alpha/beta; gene name ) an |
https://en.wikipedia.org/wiki/Luraine%20Tansey | Luraine Tansey (née Collins) (January 29, 1918 – June 18, 2014) was an American slide librarian who created the first Universal Slide Classification System in 1969 with Wendell Simons.
Life
Tansey worked to develop a "universal" slide classification scheme that would serve the needs of both catalogers and patrons. Co-authored by Wendell Simons, it was published in 1969 under the title, A slide classification system for the organization and automatic indexing of interdisciplinary collections of slides and pictures. Created mostly during her tenure at the University of California, Santa Cruz in the late 1960s-early 1970s, this system is still in use at UCSC and other institutions and is known as the Tansey or Santa Cruz system. This system was also built with computer indexing in mind.
Tansey worked with the College Art Association (CAA) for the benefit of librarians and image librarians. Her work contributed to the eventual founding of two professional societies, the Art Libraries Society of North America (ARLIS/NA) and the Visual Resources Association (VRA). In 1993 she received both the VRA and ARLIS/NA's Distinguished Service Awards. In 1993, Tansey underwrote the VRA Travel Awards Program; several Luraine Tansey Travel Awards are still awarded each year.
Luraine Tansey worked on several lectures and publications throughout the 1970’s. Her work “Potential Uses of Slide Classification Data Bases in Art History,” was in 1st international Conference of Art History Volu |
https://en.wikipedia.org/wiki/Huber%27s%20equation | Huber's equation, first derived by a Polish engineer Tytus Maksymilian Huber, is a basic formula in elastic material tension calculations, an equivalent of the equation of state, but applying to solids. In most simple expression and commonly in use it looks like this:
where is the tensile stress, and is the shear stress, measured in newtons per square meter (N/m2, also called pascals, Pa), while —called a reduced tension—is the resultant tension of the material.
Finds application in calculating the span width of the bridges, their beam cross-sections, etc.
See also
Yield surface
Stress–energy tensor
Tensile stress
von Mises yield criterion
References
Physical quantities
Structural analysis |
https://en.wikipedia.org/wiki/Battle%20of%20the%20Lerna%20Mills | The Battle of the Lerna Mills was fought on 25 June 1825, in Lerna, Greece between the Egyptian forces of Ibrahim Pasha and Greek forces led by General Yannis Makriyannis, Demetrios Ypsilantis, Andreas Metaxas and Konstantinos Mavromichalis. It was the first Greek success against Ibrahim and saved the city of Nafplio, seat of the government, from capture.
Before the conflict
After the Greek army (led by Theodoros Kolokotronis) fled to Karitena, Ibrahim's forces captured Tripolitsa, which was completely abandoned. Immediately afterwards, Ibrahim led an army of 5,000 soldiers to the plains of Argos to seize Nafplio. When Ibrahim's forces approached the Mills of Lerna on 24 June 1825, general Yannis Makrygiannis and Minister of War Andreas Metaxas organized a resistance force containing 350 Greek soldiers. General Demetrios Ypsilantis, Konstantinos Mavromichalis, Panagiotis Rodios and several philhellenes (such as François Graillard and Heinrich Treiber) volunteered in the defense of the garrison. Protecting Lerna was vital since the mills contained large quantities of grain that supplied food to Nafplio. The mills of Lerna were surrounded by a stone wall that was flanked by a deep pond and a marsh. Moreover, the garrison was supported by two gunboats that were anchored a short distance (or "musket-shot distance") from the shore.
The position was weak and they were very few compared to Ibrahim's army. Thus many were eager to leave using their horses or by boats but Makriyannis |
https://en.wikipedia.org/wiki/Depolarization%20%28disambiguation%29 | Depolarization or depolarizer may refer to:
Depolarization, a decrease in the absolute value of a cell's membrane potential
Depolarizer, a substance used to depolarize an electrochemical cell
Depolarization ratio, the intensity ratio between the parallel component and the perpendicular component of Raman scattered light
Depolarizer (optics), a device for randomizing the polarization of light |
https://en.wikipedia.org/wiki/Furylfuramide | Furylfuramide (also known as AF-2) is a synthetic nitrofuran derivative which was widely used as a food preservative in Japan since at least 1965, but withdrawn from the market in 1974 when it was observed to be mutagenic to bacteria in vitro and thus suspected of carcinogenicity. This was confirmed later when animal testing found it to cause benign and malignant tumors in the mammary glands, stomachs, esophagi, and lungs of rodents of both sexes, although insufficient evidence exists in human exposure.
This successful use of bacterial mutagenicity as a screen for carcinogenicity confirmed the use of this methodology as a rapid and efficient test, in comparison to animal testing alone, and led to its further development. The availability of such simpler tests in turn gave rise to greater government oversight and testing of compounds to which the public would be exposed.
References
Acrylamides
Carboxamides
Carcinogens
IARC Group 2B carcinogens
Nitrofurans
Toxicology
Suspected fetotoxicants
Male reproductive toxicants |
https://en.wikipedia.org/wiki/Utah%20Jazz%20all-time%20roster | The following is a list of players, both past and current, who have appeared at least in one game for the New Orleans/Utah Jazz NBA basketball franchise.
Players
Note: Statistics are correct through the end of the season.
A to B
|-
|align="left"| || align="center"|G || align="left"|Loyola Marymount || align="center"|1 || align="center"| || 28 || 613 || 55 || 69 || 175 || 21.9 || 2.0 || 2.5 || 6.3 || align=center|
|-
|align="left" bgcolor="#CCFFCC"|x || align="center"|G || align="left"|Kansas || align="center"|1 || align="center"| || 59 || 1,209 || 121 || 67 || 467 || 20.5 || 2.1 || 1.1 || 7.9 || align=center|
|-
|align="left"| || align="center"|G || align="left"|Missouri State || align="center"|1 || align="center"| || 4 || 30 || 2 || 1 || 10 || 7.5 || 0.5 || 0.3 || 2.5 || align=center|
|-
|align="left"| || align="center"|G || align="left"|Virginia Tech || align="center"|2 || align="center"|– || 51 || 677 || 82 || 93 || 281 || 13.3 || 1.6 || 1.8 || 5.5 || align=center|
|-
|align="left"| || align="center"|G || align="left"|Duke || align="center"|1 || align="center"| || 38 || 416 || 23 || 25 || 211 || 10.9 || 0.6 || 0.7 || 5.6 || align=center|
|-
|align="left"| || align="center"|G || align="left"|Rice || align="center"|2 || align="center"|– || 34 || 294 || 38 || 10 || 105 || 8.6 || 1.1 || 0.3 || 3.1 || align=center|
|-
|align="left"| || align="center"|F/C || align="left"|Penn State || align="center"|2 || align="center"|– || 104 || 1,060 || 186 || 50 || 274 || 10.2 || 1.8 | |
https://en.wikipedia.org/wiki/Growth%20hormone%20secretagogue%20receptor | Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.
Structure
Two identified transcript variants are expressed in several tissues and are evolutionarily conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for ghrelin; however, it may function to attenuate activity of isoform 1a.
GHS-R1a is a member of the G-protein-coupled receptor (GPCR) family. Previous studies have shown that GPCRs can form heterodimers, or functional receptor pairs with other types of G-protein coupled receptors (GPCRs). Various studies suggest that GHS-R1a specifically forms dimers with the following hormone and neurotransmitter receptors: somatostatin receptor 5, |
https://en.wikipedia.org/wiki/List%20of%20photovoltaics%20companies | This is a list of notable photovoltaics (PV) companies.
Grid-connected solar photovoltaics (PV) is the fastest growing energy technology in the world, growing from a cumulative installed capacity of 7.7 GW in 2007, to 320 GW in 2016. In 2016, 93% of the global PV cell manufacturing capacity utilizes crystalline silicon (cSi) technology, representing a commanding lead over rival forms of PV technology, such as cadmium telluride (CdTe), amorphous silicon (aSi), and copper indium gallium selenide (CIGS). In 2016, manufacturers in China and Taiwan met the majority of global PV module demand, accounting for 68% of all modules, followed by the rest of Asia at 14%. The United States and Canada manufactured 6%, and Europe manufactured a mere 4%. In 2021 China produced about 80% of the polysilicon, 95% of wafers, 80% of cells and 70% of modules. Module production capacity reached 460 GW with crystalline silicon technology assembly accounting for 98%.
Photovoltaics companies include PV capital equipment producers, cell manufacturers, panel manufacturers and installers. The list does not include silicon manufacturing companies.
Photovoltaic manufacturers
Top 10 by year
Summary
According to EnergyTrend, the 2011 global top ten polysilicon, solar cell and solar module manufacturers by capacity were found in countries including People's Republic of China, United States, Taiwan, Germany, Japan, and Korea.
In 2011, the global top ten polysilicon makers by capacity were GCL, Hemlock, |
https://en.wikipedia.org/wiki/Relationship%20extraction | A relationship extraction task requires the detection and classification of semantic relationship mentions within a set of artifacts, typically from text or XML documents. The task is very similar to that of information extraction (IE), but IE additionally requires the removal of repeated relations (disambiguation) and generally refers to the extraction of many different relationships.
Concept and applications
The concept of relationship extraction was first introduced during the 7th Message Understanding Conference in 1998. Relationship extraction involves the identification of relations between entities and it usually focuses on the extraction of binary relations. Application domains where relationship extraction is useful include gene-disease relationships, protein-protein interaction etc.
Current relationship extraction studies use machine learning technologies, which approach relationship extraction as a classification problem. Never-Ending Language Learning is a semantic machine learning system developed by a research team at Carnegie Mellon University that extracts relationships from the open web.
Approaches
There are several methods used to extract relationships and these include text-based relationship extraction. These methods rely on the use of pretrained relationship structure information or it could entail the learning of the structure in order to reveal relationships. Another approach to this problem involves the use of domain ontologies. There is also the ap |
https://en.wikipedia.org/wiki/KvLQT2 | Kv7.2 (KvLQT2) is a voltage- and lipid-gated potassium channel protein coded for by the gene KCNQ2.
It is associated with benign familial neonatal epilepsy.
Function
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Ligands
ICA-069673: channel opener at KCNQ2/Q3, 20-fold selective over KCNQ3/Q5, no measurable activity against a panel of cardiac ion channels (hERG, Nav1.5, L type channels, and KCNQ1) and no activity on GABAA gated channels at 10 μM. A range of related benzamides exhibited activity, of which compound number 40 is shown here.
ML252: channel inhibitor, IC50 = 70nM.
Phosphatidylinositol 4,5-bisphosphate (PIP2)
References
Further reading
External links
Ion channels
Proteins |
https://en.wikipedia.org/wiki/KvLQT3 | Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.
It is associated with benign familial neonatal epilepsy.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).
Interactions
KvLQT3 has been shown to interact with KCNQ5.
References
Further reading
External links
Ion channels
Proteins |
https://en.wikipedia.org/wiki/Crystal%20Kay%20discography | The discography of Japanese contemporary R&B singer Crystal Kay consists of 12 studio albums, three extended plays, five compilation albums, four video albums and numerous single releases. Crystal Kay debuted as a singer at 13 years of age in 1999 under Epic Records Japan. Her third album Almost Seventeen (2002) saw a great leap in popularity for Crystal Kay, reaching number two on Oricon's albums chart. In 2005, Crystal Kay sang the eponymous theme song for the Tsuyoshi Kusanagi drama Koi ni Ochitara: Boku no Seikō no Himitsu. "Koi ni Ochitara" became Crystal Kay's most successful single, being certified for a million ringtone downloads.
In 2011, Crystal Kay signed to Delicious Deli Records, after 11 years with Epic Records, and released the album Vivid (2012). In March 2013 Crystal Kay relocated to New York City to pursue an American debut through Copetin Inc, releasing the single "Busy Doing Nothing" a year later. In October 2014, Crystal Kay re-focused on Japan by switching her management to LDH.
Studio albums
Extended plays
Compilation albums
Cover albums
Soundtrack albums
Singles
As a lead artist
As a featured artist
Promotional singles
Other appearances
Video albums
Notes
References
Discographies of Japanese artists
Pop music discographies
Rhythm and blues discographies |
https://en.wikipedia.org/wiki/Tennessee%20State%20Route%20266 | State Route 266 (SR 266) is a state highway in Middle Tennessee. The southern terminus is in a currently undeveloped section of Smyrna at an interchange with I-24. The northern terminus is in Lebanon at an intersection with US 70.
Route description
Rutherford County
SR 266 begins in Rutherford County in Smyrna at an interchange with I-24 (Exit 66). It goes east as a 4-lane, changing to a 6-lane, divided highway called Sam Ridley Parkway, a major thoroughfare featuring numerous strip malls, apartments, a high school, and a hospital. It has an interchange with US 41/US 70S/SR 1 (N Lowry Street) on the southern edge of Smyrna Airport. SR 266 then becomes undivided and continues east to an intersection with SR 102 (Nissan Drive), where Sam Ridley Parkway officially end and SR 266 continues east as Jefferson Pike. The highway then narrows to 2-lanes and crosses a bridge over the Stones River just south of Percy Priest Lake, where it leaves Smyrna. SR 266 then passes through rural areas to come to have an interchange with I-840 (Exit 61) before passing through Walterhill and having an intersection with US 231/SR 10. SR 266 then continues east through farmland to pass through Lascassas, where it has a short concurrency with SR 96 before turning northward and crossing into Wilson County.
Wilson County
SR 266 winds its way northward through farmland as Cainsville Road, where it passes through Norene and has an intersection with SR 265. The highway then enters Lebanon and passes thr |
https://en.wikipedia.org/wiki/Censoring%20%28statistics%29 | In statistics, censoring is a condition in which the value of a measurement or observation is only partially known.
For example, suppose a study is conducted to measure the impact of a drug on mortality rate. In such a study, it may be known that an individual's age at death is at least 75 years (but may be more). Such a situation could occur if the individual withdrew from the study at age 75, or if the individual is currently alive at the age of 75.
Censoring also occurs when a value occurs outside the range of a measuring instrument. For example, a bathroom scale might only measure up to 140 kg. If a 160-kg individual is weighed using the scale, the observer would only know that the individual's weight is at least 140 kg.
The problem of censored data, in which the observed value of some variable is partially known, is related to the problem of missing data, where the observed value of some variable is unknown.
Censoring should not be confused with the related idea truncation. With censoring, observations result either in knowing the exact value that applies, or in knowing that the value lies within an interval. With truncation, observations never result in values outside a given range: values in the population outside the range are never seen or never recorded if they are seen. Note that in statistics, truncation is not the same as rounding.
Types
Left censoring – a data point is below a certain value but it is unknown by how much.
Interval censoring – a data |
https://en.wikipedia.org/wiki/Quality%20control%20and%20genetic%20algorithms | The combination of quality control and genetic algorithms led to novel solutions of complex quality control design and optimization problems. Quality is the degree to which a set of inherent characteristics of an entity fulfils a need or expectation that is stated, general implied or obligatory. ISO 9000 defines quality control as "A part of quality management focused on fulfilling quality requirements". Genetic algorithms are search algorithms, based on the mechanics of natural selection and natural genetics.
Quality control
Alternative quality control (QC) procedures can be applied to a process to test statistically the null hypothesis, that the process conforms to the quality specifications and consequently is in control, against the alternative, that the process is out of control. When a true null hypothesis is rejected, a statistical type I error is committed. We have then a false rejection of a run of the process. The probability of a type I error is called probability of false rejection. When a false null hypothesis is accepted, a statistical type II error is committed. We fail then to detect a significant change in the probability density function of a quality characteristic of the process. The probability of rejection of a false null hypothesis equals the probability of detection of the nonconformity of the process to the quality specifications.
The QC procedure to be designed or optimized can be formulated as:
(1)
where denotes a statistical decision rule, |
https://en.wikipedia.org/wiki/Survival%20of%20motor%20neuron | Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.
SMN is found in the cytoplasm of all animal cells and also in the nuclear gems. It functions in transcriptional regulation, telomerase regeneration and cellular trafficking. SMN deficiency, primarily due to mutations in SMN1, results in widespread splicing defects, especially in spinal motor neurons, and is one cause of spinal muscular atrophy. Research also showed a possible role of SMN in neuronal migration and/or differentiation.
Function
The SMN protein contains GEMIN2-binding, Tudor and YG-Box domains. It localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as GEMIN2 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.
SMN complex
SMN complex refers to the entire multi-protein complex involved in the assembly of snRNPs, the essential components of spliceosomal machinery. The complex, apart from the "proper" survival of motor neuron protein, includes at least six other proteins (gem-associated protein 2, 3, 4, 5, 6 and 7.
Interactions
SMN has been shown to interact with:
Bcl-2,
Coilin,
DDX20, |
https://en.wikipedia.org/wiki/History%20of%20numerical%20solution%20of%20differential%20equations%20using%20computers | Differential equations, in particular Euler equations, rose in prominence during World War II in calculating the accurate trajectory of ballistics, both rocket-propelled and gun or cannon type projectiles. Originally, mathematicians used the simpler calculus of earlier centuries to determine velocity, thrust, elevation, curve, distance, and other parameters.
New weapons, however, such as Germany's giant cannons, the "Paris Gun" (Encyclopedia Astronautica) and "Big Bertha," and the V-2 rocket, meant that projectiles would travel hundreds of miles in distance and dozens of miles in height, in all weathers. As a result, variables such as diminished wind resistance in thin atmospheres and changes in gravitational pull reduced accuracy using the historic methodology. There was the additional problem of planes that could now fly hundreds of miles an hour. Differential equations were applied to stochastic processes. Developing machines that could speed up human calculation of differential equations led in part to the creation of the modern computer through the efforts of Vannevar Bush, John von Neumann and others.
According to Mary Croarken in her paper "Computing in Britain During World War II," by 1945, the Cambridge Mathematical Laboratory created by John Lennard-Jones utilized the latest computing devices to perform the equations. These devices included a model "differential analyser," and the Mallock machine, described as "an electrical simultaneous equation solver." Accordi |
https://en.wikipedia.org/wiki/Chromic%20acid%20cell | The Chromic acid cell is a type of primary cell which uses chromic acid as a depolarizer. The chromic acid is usually made by acidifying (with sulfuric acid) a solution of potassium dichromate. The old name for potassium dichromate is potassium bichromate and the cell is often called a Bichromate cell. This type of cell is now only of historical interest.
History
Construction
The main elements of the cell are:
Anode, zinc
Electrolyte, dilute sulfuric acid
Depolarizer, chromic acid
Cathode, carbon
The cell is made in two forms - the single-fluid type, attributed to Poggendorff and the two-fluid type, attributed to Fuller. In both cases, cell voltage is about 2 volts.
Poggendorff cell
The cell is set up in a long-necked glass bottle with a zinc plate located between two carbon plates. The electrolyte and depolarizer are then mixed. The mixture would dissolve the zinc plate even when the cell is not in use, so there is a mechanism for lifting the zinc plate out of the liquid and storing it in the neck of the bottle.
Fuller cell
The cell is set up in a glass, or glazed earthenware, pot. This contained the chromic acid solution, the carbon plate and a porous pot. Inside the porous pot is dilute sulfuric acid, the zinc rod, and a small quantity of mercury. The mercury formed an amalgam with the zinc and this reduced "local action", i.e. unwanted dissolution of the zinc when the cell is not in use.
See also
List of battery types
References
External links
|
https://en.wikipedia.org/wiki/LM3875 | LM3875 was a 56 watt amplifier chip made by Texas Instruments (previously National Semiconductor). It was very popular in the DIY audio community for its low parts count and its high-performance audio capabilities. It was the main chip inside many gainclone amplifiers which are based on the Gaincard amplifier.
This part has become obsolete and an EOL notice has been issued for it. The functional equivalent IC, the LM3886, has two additional signals that must be addressed before it can be substituted, the mute function and a virtual gnd pin.
References
External links
Product page (pdf datasheet)
Chip amp projects, most based on the LM3875
status of LM3875 at DigiKey
Audio amplifiers
Linear integrated circuits |
https://en.wikipedia.org/wiki/Vrap%C4%8Di%C5%A1te | Vrapčište (, , ) is a village and seat of the municipality of Vrapčište, North Macedonia.
History
In statistics gathered by Vasil Kanchov in 1900, the village of Vrapčište was inhabited by 1300 Turks, 325 Orthodox Bulgarians, 165 Muslim Albanians and 50 Romani.
A policy of Turkification of the Albanian population was employed by the Yugoslav authorities in cooperation with the Turkish government, stretching the period of 1948-1959. Starting in 1948, Turkish schools were opened in areas with large Albanian majorities, such as Vrapčište.
Demographics
As of the 2021 census, Vrapčište had 4,003 residents with the following ethnic composition:
Turks 2,765
Albanians 912
Persons for whom data are taken from administrative sources 203
Macedonians 118
Others 5
According to the 2002 census, the village had a total of 4,874 inhabitants. Ethnic groups in the village include:
Turks 2,899
Albanians 1,777
Macedonians 172
Others 26
Sports
Local football club FK Vrapčište plays in the OFS Gostivar league.
References
External links
Villages in Vrapčište Municipality
Albanian communities in North Macedonia |
https://en.wikipedia.org/wiki/Dave%20Swindlehurst | David Swindlehurst (born 6 January 1956 in Edgware, Middlesex) is an English former footballer who played as a striker.
Career
Swindlehurst came up through the ranks at Crystal Palace, playing youth football in the early 1970s with future West Ham United teammate Alan Devonshire. Starting his senior career in 1973, he played for Palace for eight seasons and scored 81 goals in 278 appearances. Swindlehurst first joined Derby County as a loan player, two months before his transfer was made permanent in April 1980. Derby paid £410,000, a then-record for the club.
West Ham manager John Lyall brought Swindlehurst to Upton Park for £160,000 in March 1983. Injuries hampered his chances of regular first-team football. He played his last game for West Ham on 27 April 1985 against Luton Town and after 71 League and cup games for the east Londoners, he moved on to Sunderland.
After a spell in Cyprus with Anorthosis Famagusta, Swindlehurst returned to London to play for Wimbledon, but he managed just two appearances in the season they won the 1988 FA Cup Final, beating Liverpool. He later played for Colchester United, and on loan at Peterborough United.
Coaching career
After spells playing and managing at non-League Bromley and Molesey, he rejoined his former club Crystal Palace to take up a coaching role within the youth academy. He was promoted to reserve team manager in 2001, but was sacked in October 2002.
Swindlehurst joined Crawley Town as assistant manager in 2003. He was sac |
https://en.wikipedia.org/wiki/Sergei%20Skorykh | Sergei Skorykh (born 25 May 1984) is a Kazakh football midfielder.
Career statistics
Club
International
Statistics accurate as of match played 1 December 2014
References
External links
1984 births
Living people
Men's association football midfielders
Kazakhstani men's footballers
Kazakhstan men's international footballers
Kazakhstan Premier League players
FC Irtysh Pavlodar players
FC Tobol players
FC Zhetysu players
FC Taraz players
FC Kaisar players
FC Shakhter Karagandy players
Sportspeople from Petropavl |
https://en.wikipedia.org/wiki/Murat%20Suyumagambetov | Murat Suyumagambetov (; born 14 October 1983 in Aktau) is a Kazakhstani football forward who last played for FC Kyran. He also plays for the Kazakhstan national football team.
Career statistics
International goals
References
1983 births
Living people
Men's association football midfielders
Kazakhstani men's footballers
Kazakhstan men's international footballers
Kazakhstan Premier League players
FC Zhenis players
FC Shakhter Karagandy players
FC Tobol players
FC Caspiy players
FC Zhetysu players
FC Ordabasy players
FC Kairat players
FC Vostok players
FC Taraz players
People from Aktau |
https://en.wikipedia.org/wiki/James%20Kennedy%20%28social%20psychologist%29 | James Kennedy (born November 5, 1950) is an American social psychologist, best known as an originator and researcher of particle swarm optimization. The first papers on the topic, by Kennedy and Russell C. Eberhart, were presented in 1995; since then tens of thousands of papers have been published on particle swarms. The Academic Press / Morgan Kaufmann book, Swarm Intelligence, by Kennedy and Eberhart with Yuhui Shi, was published in 2001.
The particle swarm paradigm draws on social-psychological simulation research in which Kennedy had participated at the University of North Carolina, integrated with evolutionary computation methods that Eberhart had been working with in the 1990s. The result was a problem-solving or optimization algorithm based on the principles of human social interaction. Individuals begin the program with random guesses at the problem solution. As the program runs, the "particles" share their successes with their topological neighbors; each particle is both teacher and learner. Over time, the population converges reliably on optimal vectors.
While there has been a trend in the research literature toward a "Gbest" or centralized particle network, Blackwell and Kennedy (2018) demonstrated the importance of a distributed population topology in solving more complex problems.
A recent paper discusses the possible contribution of human female orgasm to the species' prosociality.
Kennedy has been an active combatant in the controversy over sex education in |
https://en.wikipedia.org/wiki/Ruma%20%28disambiguation%29 | Ruma is a town and municipality in Vojvodina, Serbia.
Ruma may also refer to:
Rumā, wife of Sugriva, a character of Ramayana
Ruma, Illinois, a village in Illinois, United States
23S rRNA (uracil1939-C5)-methyltransferase, an enzyme |
https://en.wikipedia.org/wiki/ESAT-6 | ESAT-6 or Early Secreted Antigenic Target 6 kDa, is produced by Mycobacterium tuberculosis, it is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10.
ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction. It has also been studied that the inactivation of ESAT-6 leads to decreased virulence of M. tuberculosis. Secretion of the ESAT-6 protein is one of the main determining factors in the virulence of the M. tuberculosis. ESAT-6 has more commonly become a marker for the TB diagnosis and treatment. There is also the use of the ESAT increase the production of virulent factors that cause for the increase in pathogenicity of TB.
ESAT-6 is one of the main proteins that is inhibited in the production of vaccines for M. tuberculosis with the combination of the increased antigenic factors agβ5-A and the agβ5-C. There are studies that are currently trying to connect the linkage between ESAT-6 and the epithelial cells that are in the lungs, which has shown the dependence on the induction of the IL-8 promoter.
ESAT-6 and CFP-10
There are also connections between the ESAT-6 marker and the CFP-10 marker. These are both being produced in Mycobacterium tuberculosis cells and is subject to the positive correlation of virulence to the amount of protein produced. Recent work shows that the production of these proteins is a proc |
https://en.wikipedia.org/wiki/CFP-10 | CFP-10 within bacterial proteins (also known as ESAT-6-like protein esxB or secreted antigenic protein MTSA-10 or 10 kDa culture filtrate antigen CFP-10) is a protein that is encoded by the esxB gene.
CFP-10 is a 10 kDa secreted antigen from Mycobacterium tuberculosis. It forms a 1:1 heterodimeric complex with ESAT-6. Both genes are expressed from the RD1 region of the bacterial genome and play a key role in the virulence of the infection.
Function
10-kDa culture filtrate protein (CFP-10) is an antigen that contributes to the virulence Mycobacterium tuberculosis. CFP-10 forms a tight 1:1 heterodimeric complex with 6kDaA early secreted antigen target (ESAT-6). In the mycobacterial cell, these two proteins are interdependent on each other for stability. The ESAT-6/CFP-10 complex is secreted by the ESX-1 secretion system, also known as the RD1 region. Mycobacterium tuberculosis uses this ESX-1 secretion system to deliver virulence factors into host macrophage and monocyte white blood cells during infection.
In Mycobacterium tuberculosis, the core components of the whole ESX-1 secretion system include Rv3877, and two AAA ATPases, including Rv3870 and Rv3871, a cytosolic protein. The ESAT-6/CFP-10 heterodimer complex is targeted for secretion by a C-terminal signal sequence on CFP-10 that is recognized by the cytosolic Rv3871 protein. Rv3871 then interacts with the CFP-10 C-terminal, and escorts the ESAT-6/CFP-10 complex to Rv3870 and Rv3877, a multi-transmembrane protein |
https://en.wikipedia.org/wiki/Crystal%20Carson | Crystal Carson (born June 24, 1967) is an American acting coach and former actress.
Early life
Carson has been teaching and coaching professionally in Los Angeles for the past 20 years. Prior to that, she worked as an actress in 25 theatre repertory and summer stock companies. She appeared in several films, including "Who's That Girl" with Madonna, and starred in the cult spoof film "Killer Tomatoes Strike Back" with John Astin. Carson also played the lead actress in the suspense drama "Eclipse," the female lead in the action film "Cartel," the love interest in "Fade Away" opposite Noah Blake, and portrayed Blue Star in the video game "Blue Star" with Lamont Bentley, among others.
Career
Among her television credits are a contract role as Julia Barrett on the ABC soap opera General Hospital (1991–1993; 1997; 1998). Her character Julia was a successful businesswoman and older sister to troubled teen Brenda (Vanessa Marcil).
She was also cast as Trish in the 1985 B-movie horror film The Zero Boys and as Denise, a bridesmaid in the 1987 Madonna film Who's That Girl.
In television, Carson appeared for 3 weeks on the award-winning episodic JAG, 6 weeks on the mega-hit Dallas, and had guest starring roles on Ellen, Charles in Charge, Midnight Caller, Cheers, Thirtysomething, Simon & Simon and Night Court.
As for the above-mentioned role of “Julia Barrett” that Carson portrayed on General Hospital, it was responsible for her being voted "Best New Female" by Soap Opera Digest |
https://en.wikipedia.org/wiki/TSP-1 | Term TSP-1 may refer to:
Thrombospondin 1, a protein that in humans in encoded by the THBS1 gene
Granzyme A, an enzyme class |
https://en.wikipedia.org/wiki/Altezza%20lights | Altezza lights (also known as Lexus lights, Euro lights, crystal lights, or clear lights) are vehicle tail lamp clusters consisting of one or more internal lamp units, covered with a clear (or tinted) acrylic cover. This style of taillight was made popular by Lexus and has been stock equipment on Toyota Altezza, Lexus IS300 and IS200 models since 1998. Some Altezza lights also use LED lighting.
Origin
The style was first used on the rear light clusters of the Toyota Altezza in 1998, which was sold elsewhere in the world months later as the Lexus IS. Prior to the release of the Altezza, the Toyota Supra Mark IV also used an encased tail lamp assembly in gun-metal grey that is sometimes credited with starting the trend. The Mark I Altezza taillight housing was finished in chrome.
Altezza lights are commonly installed as an aftermarket part on modified cars, and the styling cues of the rear light clusters were also copied by a number of other vehicles and car manufacturers. This includes cars like the Toyota Prius C, third and fourth generation Nissan Altima, second and third generation Subaru Impreza hatchback and second generation sedan, second generation Chevrolet Aveo sedan, 2011–2016 Honda Brio, first generation Mazda6, and 2007–2016 Mitsubishi Lancer. It is also seen on SUVs such as the fourth generation Mitsubishi Pajero, first and third generation Lexus RX, 2003–2006 Indonesian-built first generation Nissan Terrano and 2011–2015 Toyota Fortuner.
References
Vehicle mo |
https://en.wikipedia.org/wiki/Aille%20River%20%28County%20Clare%29 | The Aille River in County Clare in Ireland rises on the slopes of Slieve Elva in the Burren. It flows through the spa town of Lisdoonvarna and on to Doolin, where it reaches the sea not far from the Cliffs of Moher. Flowing through Lisdoonvarna it gives rise to sulphur, iron, and magnesium wells there. In summer, the river often disappears into the limestone cave system in Doolin.
Rivers of County Clare |
https://en.wikipedia.org/wiki/Shutdown%20valve | A shutdown valve (also referred to as SDV or emergency shutdown valve, ESV, ESD, or ESDV; or safety shutoff valve) is an actuated valve designed to stop the flow of a hazardous fluid upon the detection of a dangerous event. This provides protection against possible harm to people, equipment or the environment.
Shutdown valves form part of a safety instrumented system. The process of providing automated safety protection upon the detection of a hazardous event is called functional safety.
Shutdown valves are primarily associated with the petroleum industry although other industries may also require this type of protection system. ESD valves are required by law on any equipment placed on an offshore drilling rig to prevent catastrophic events like the BP Horizon explosion in the Gulf of Mexico in 2010.
A safety shutoff valve should be fail-safe, that is close upon failure of any element of the input control system (such as temperature controllers, steam pressure controllers), air pressure, fuel pressure, current from a flame detector, or current from other safety devices such as low water cutoff, and high pressure cutoff.
A blowdown valve (BDV) is a type of shutdown valve designed to depressurize a pressure vessel by directing vapour to a flare, vent or blowdown stack in an emergency. BDVs fail-safe to the open position upon failure of the control system. The type of valve, type of actuation and performance measurement are similar to an ESD valve.
Types
For fluids, metal s |
https://en.wikipedia.org/wiki/Katia%20Dandoulaki | Ekaterini "Katia" Dandoulaki (; born May 16, 1948) is a Greek theatre, television and film actress. She is best known for her role as protagonist Virna Drakou on the Greek television series Lampsi in the 1990s. Katia also starred in the series I Zoi tis Allis, which surpassed 70% of the ratings and in Vals me 12 Theous in 2012 with at least 60% ratings on the Ant1 network. It was the 2012 record for the network.
Biography
She was the spouse of the Greek intellectual, translator, writer Marios Ploritis, who translated many of her plays, until his death in 2006.
Dandoulaki studied English at Boston University for one year (1968) and speaks English fluently.
Career
Katia Dandoulaki starred in many popular Greek films, like Papaflessas (1971) with Dimitris Papamichail. She played the role of Marmo Panteou, a young wife, in the classic TV series "Oi Pantheoi" (1977), based on a classic novel by Tassos Athanassiadis. During the 90s she starred as Virna Drakou in the popular Greek soap opera of Nikos Foskolos Lampsi.
She also played Maria Callas in Terence MacNally's Master Class, and Blanche in A Streetcar Named Desire. She was one of the lead stars in the TV series, "Istera irthan oi melisses" (2000), directed by Yiannis Koutsomitis. It was one of the few successes that ET1, the state TV channel, had during that period. During the 2001-2002 season she played Emma in the classic Pinter play 'Betrayal'. It was a big success, and directed by Stamatis Fasoulis. Her co-stars were S |
https://en.wikipedia.org/wiki/List%20of%20career%20achievements%20by%20Tiger%20Woods | This page details statistics, records, and other achievements pertaining to Tiger Woods.
Career records and statistics
Woods has won 82 official PGA Tour events, tied with Sam Snead also 82, and nine ahead of Jack Nicklaus's 73 wins. (See List of golfers with most PGA Tour wins.)
Woods has won 15 majors, second all time behind Jack Nicklaus' 18.
Woods is 14–1 when going into the final round of a major with at least a share of the lead.
Woods scoring average in 2000 is the lowest in PGA Tour history, both adjusted, 67.79, and unadjusted, 68.17.
Woods has the lowest career scoring average in PGA Tour history.
Woods has amassed the most career earnings of any player in PGA Tour history (even after inflation is considered).
Woods is one of five players (along with Gene Sarazen, Ben Hogan, Gary Player, and Jack Nicklaus) to have won all four professional major championships in his career, known as the Career Grand Slam, and was the youngest to do so.
Woods is the only player to have won all four professional major championships in a row, accomplishing the feat in the 2000–2001 seasons. This feat became known as the "Tiger Slam".
Woods set the all-time PGA Tour record for most consecutive cuts made, with 142. The streak started in 1998, he set the record at the 2003 Tour Championship with 114 (passing Byron Nelson's previous record of 113 and Jack Nicklaus at 105) and extended this mark to 142 before it ended on May 13, 2005 at the EDS Byron Nelson Championship. Many con |
https://en.wikipedia.org/wiki/TRAF6 | TRAF6 is a TRAF human protein.
Function
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
Interactions
TRAF6 has been shown to interact with:
ASK1,
CD40,
FHL2,
HSPB2,
IKBKG,
IRAK1,
IRAK2,
TAB1,
MAP3K7IP2,
MAP3K7
PPP4C,
RANK,
SDCBP,
SIGIRR,
Sequestosome 1,
TAX1BP1,
TNFAIP3,
TNFRSF13B,
UBE2N, and
Ubiquitin C.
Model organisms
Model organisms have been used in the study of TRAF6 function. A conditional |
https://en.wikipedia.org/wiki/Lymphocyte%20antigen%2096 | Lymphocyte antigen 96, also known as "Myeloid Differentiation factor 2 (MD-2)," is a protein that in humans is encoded by the LY96 gene.
The protein encoded by this gene is involved in binding lipopolysaccharide with Toll-Like Receptor (TLR4).
Function
The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. That is, the primary interface between TLR4 and MD-2 is formed before binding LPS and the dimerization interface is induced by binding LPS.
Structure
MD-2 has a β-cup fold structure composed of two anti-parallel β sheets forming a large hydrophobic pocket for ligand binding.
Interactions
Lymphocyte antigen 96 has been shown to interact with TLR 4.
When LPS binds to a hydrophobic pocket in MD-2, it directly mediates dimerization of the two TLR4-MD-2 complexes. Thus, MD-2 form a heterodimer that recognizes a common pattern in structurally diverse LPS molecules. These interactions allow TLR4 to recognize LPS. Macrophages in MD-2 knockout mice are unresponsive to LPS.
LPS is extracted from the bacterial membrane and transferred to TLR4-MD-2 by two accessory proteins, LPS-binding protein and CD14, to induce innate immune response.
References
Further reading
External links |
https://en.wikipedia.org/wiki/Sergei%20Fokin%20%28ice%20hockey%29 | Sergei Fokin (born May 2, 1963 in Moscow, Soviet Union) is a former professional Russian ice hockey player.
He started his career in the Soviet Union in 1983, playing for Crystal Saratov. In 1984 he signed with Spartak Moskva and he stayed with them until 1992, when he moved to Sweden and sign with VIK Västerås HK, where he joined fellow countryman Mishat Fahrutdinov. After two season with Västerås, he signed for another Swedish team, Färjestads BK, a team that he wouldn't leave until 2002. During his time with Färjestad he won three Swedish Championships, 1997, 1998 and 2002. When he left Färjestad, he called it his retirement and he signed with a lower league team Borås HC. But during his first season with Borås was he was loaned to Malmö Redhawks for a couple of games. But these were his last games at the top level. He played two more seasons with Borås HC and in 2005 retired from ice hockey.
He represented Russia in four Hockey World Championships.
Career statistics
International statistics
External links
1963 births
Borås HC players
Färjestad BK players
HC Spartak Moscow players
Living people
Malmö Redhawks players
Russian ice hockey defencemen
Soviet ice hockey defencemen
VIK Västerås HK players |
https://en.wikipedia.org/wiki/Crotamine | Crotamine is a toxin present in the venom of the South American rattlesnake (Crotalus durissus terrificus). It is a 42-residue long protein containing 11 basic residues (9 lysines, 2 arginines) and 6 cysteines. It has also been isolated from the venom of North American prairie rattlesnake, Crotalus viridis viridis. It was first isolated and purified by Brazilian scientist José Moura Gonçalves, and later intensively studied by his group of collaborators at the Medical School of Ribeirão Preto of the University of São Paulo.
Biological function
Crotamine has a number of biological actions: it acts on cell membrane's sodium channels, is slightly analgesic and is myotoxic, i.e., it penetrates the cells of muscles and promotes necrosis. Crotamine is homologous with other venom myotoxins and is similar to α-,β-defensins.
Biochemistry and mechanism
The amino acid sequence (, Cys4-Cys36, Cys11-Cys30, Cys18-Cys37) and the 3D molecular structure of crotamine have already been determined.
The protein structure of crotamine could not be initially determined through protein crystallization nor X-ray diffraction. It was speculated that the difficulty was because crotamine has so many isoforms, leading to the formation of aggregates and different possible conformations of the protein. The structure and the shape of the protein was proposed through a 3D model generated by Siqueira et al. (2002) based on computational calculations that were supported with intensive molecular dynamics simul |
https://en.wikipedia.org/wiki/HHV%20capsid%20portal%20protein | HHV Capsid Portal Protein, or HSV-1 UL-6 protein, is the protein which forms a cylindrical portal in the capsid of Herpes simplex virus (HSV-1). The protein is commonly referred to as the HSV-1 UL-6 protein because it is the transcription product of Herpes gene UL-6.
The Herpes viral DNA enters and exits the capsid via the capsid portal. The capsid portal is formed by twelve copies of portal protein arranged as a ring; the proteins contain a leucine zipper sequence of amino acids which allow them to adhere to each other. Each icosahedral capsid contains a single portal, located in one vertex.
The portal is formed during initial capsid assembly and interacts with scaffolding proteins that construct the procapsid.
When the capsid is nearly complete, the viral DNA enters the capsid (i.e., the DNA is encapsidated) by a mechanism involving the portal and a DNA-binding protein complex similar to bacteriophage terminase. Multiple studies suggest an evolutionary relationship between Capsid Portal Protein and bacteriophage portal proteins.
When a virus infects a cell, it is necessary for the viral DNA to be released from the capsid. The Herpes virus DNA exits through the capsid portal.
The genetic sequence of HSV-1 gene UL-6 is conserved across the family Herpesviridae and this family of genes is known as the "Herpesvirus UL6-like" gene family. "UL-6" is nomenclature meaning that the protein is genetically encoded by the sixth (6th) open reading frame found in the viral g |
https://en.wikipedia.org/wiki/Tenascin%20X | A member of the tenascin family, tenascin X (TN-X) also known as flexillin or hexabrachion-like protein is a 450kDa glycoprotein that is expressed in connective tissues. TN-X possesses a modular structure composed, from the N- to the C-terminal part by a Tenascin assembly domain (TAD), a series of 18.5 repeats of epidermal growth factor (EGF)-like motif, a high number of Fibronectin type III (FNIII) module, and a fibrinogen (FBG)-like globular domain. In humans, tenascin X is encoded by the TNXB gene.
Gene
This gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. TNXB also possesses a pseudogene, TNXA, which is a consequence of MHC classe III locus duplication during evolution. Strong 3' homology between TNXB and TNXA can provoke genetic recombination between the two loci, thus leading to the apparition of TNXA/TNXB chimera.
Function
TN-X is constitutively expressed in adult tissues such as skin, ligaments, tendons, lungs, kidneys, optic nerves, mammary and adrenal glands, blood vessels, testis, and ovaries. It is also found in different compartments of the digestive tract, including pancreas, stomach, jejunum, ileum, and colon. In this wide variety of organs, TN-X is mainly located within the connective tissue such as peritendineum (external structural component of tendons), epimysium and perimysium (muscl |
https://en.wikipedia.org/wiki/Simen%20Brenne | Simen Brenne (born 17 March 1981) is a Norwegian footballer who plays for Råde.
Brenne has played in 15 games for Norway, and scored one goal since his debut in 2007.
Career statistics
International goals
Honours
Club
Fredrikstad
Norwegian Football Cup (1): 2006
Lillestrøm
Norwegian Football Cup (1): 2007
Strømsgodset
Tippeligaen (1): 2013
References
External links
Odd Grenland profile
1981 births
Living people
Norwegian men's footballers
Norway men's international footballers
Norway men's under-21 international footballers
Moss FK players
Fredrikstad FK players
Lillestrøm SK players
Odds BK players
Strømsgodset Toppfotball players
Sarpsborg 08 FF players
Eliteserien players
Norwegian First Division players
Footballers from Fredrikstad
Men's association football midfielders |
https://en.wikipedia.org/wiki/Dehydroretinal | Dehydroretinal (3,4-dehydroretinal) is a derivative metabolite of retinal belonging to the group of vitamin A2 as a retinaldehyde form, besides the endogenously present 3,4-dehydroretinol and 3,4-dehydroretinoic acid.
The livers of some freshwater fishes and some fish found in India contain a higher ratio of dehydroretinal to retinal than do other species.
See also
Retinene
References
Vision
Signal transduction
Apocarotenoids
Photosynthetic pigments
Vitamins |
https://en.wikipedia.org/wiki/Amphipyrinae | Amphipyrinae is a subfamily of owlet moths in the family Noctuidae. There are more than 50 genera and 210 described species in Amphipyrinae, although the classifications are likely to change over time.
This subfamily has been used as a catchall for members of Noctuidae that don't fit well into other subfamilies. As such, many of its members lack morphological traits that would allow assignment into one of the other subfamilies. Genetic analysis conducted on Amphipyrinae is improving the classification of these genera.
In 2021, phylogenetic research resulted in 11 genera being transferred from Amphipyrinae to six different subfamilies, and it is expected that more members of Amphipyrinae will be reassigned as further research is done.
Psaphidini is included here as a tribe, but is sometimes treated as the subfamily Psaphidinae. The Australian genera in Acronictinae are sometimes considered part of Amphipyrinae.
Genera
These 52 genera belong to the subfamily Amphipyrinae:
Tribe Amphipyrini Guenée, 1837
Amphipyra Ochsenheimer, 1816
Tribe Psaphidini Grote, 1896
Subtribe Feraliina Poole, 1995
Apsaphida Franclemont, 1973
Feralia Grote, 1874
Miracavira Franclemont, 1937
Paratrachea Hampson, 1908
Viridemas Smith, 1908
Subtribe Nocloina Poole, 1995
Emarginea Guenée, 1852
Euamiana Barnes & Benjamin, 1927
Lythrodes Smith, 1903
Nocloa Smith, 1906
Oslaria Dyar, 1904
Paramiana Barnes & Benjamin, 1924
Petalumaria Buckett & Bauer, 1968
Prothrinax Hampson, 1908
Redingto |
https://en.wikipedia.org/wiki/Glivenko%27s%20theorem | Glivenko's theorem may refer to:
Glivenko's theorem (probability theory)
Glivenko's theorem or Glivenko's translation, a double-negation translation for propositional logic
See also
Glivenko–Cantelli theorem
Glivenko–Stone theorem |
https://en.wikipedia.org/wiki/GRB10 | Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
Function
The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
Animal studies
Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.
Interactions
GRB10 has been shown to interact with
Abl gene,
BCR gene,
C-Raf,
c-Kit,
Insulin receptor,>
Insulin-like growth factor 1 receptor,
MAP2K1, and
RET proto-oncogene.
References
Further reading
External links |
https://en.wikipedia.org/wiki/DPNI | DPNI may refer to:
Movement Against Illegal Immigration
DpnI, a Type IIM restriction enzyme which digests methylated DNA |
https://en.wikipedia.org/wiki/Inner%20tunnel | The basilar membrane stretches from the tympanic lip of the osseous spiral lamina to the basilar crest and consists of two parts, an inner and an outer. The inner is thin, and is named the inner tunnel (or zona arcuata): it supports the spiral organ of Corti.
References
External links
http://www.anatomyatlases.org/MicroscopicAnatomy/Section16/Plate16312.shtml
https://web.archive.org/web/20070615012500/http://www3.umdnj.edu/histsweb/lab14/lab14cochlea.html
Auditory system |
https://en.wikipedia.org/wiki/Healia | Healia is a health vertical search engine and online health community. Healia's search engine uses algorithms to assess quality and to categorize Web documents. Healia Communities is composed of online health support groups that enable people to share health experiences, connect with others, and ask questions of peers and health professionals. Healia, Inc. is located in Bellevue, Washington, USA.
Quality Index Score and Personalization Algorithms
Healia use patent-pending Quality Index Score to judge the quality of search results.
Healia uses algorithms to assess the content and audience focus of health Web pages and allows users to filter search results by those characteristics.
Management team
President & Founder: Thomas R. Eng (VMD, MPH).
Thomas (Tom) Eng received a Small Business Innovation Research (SBIR) Award from the National Institutes of Health(NIH) in 2001 to develop this website. The National Cancer Institute (part of the NIH) assisted with research and development, and Healia was incorporated in March 2005. It became available to the public in September 2006.
Healia was acquired by Meredith Corporation in June 2007.
Healia's CTO is Mike Schultz (PhD) who runs the technology development.
AMSA Partnership
In 2009, Healia partnered with the American Medical Student Association (AMSA) to provide medical students an opportunity to answer health questions posed in Healia Communities alongside licensed professionals.
Drawbacks
The searching results are heavil |
https://en.wikipedia.org/wiki/Victor%20Klee | Victor LaRue Klee, Jr. (September 18, 1925 – August 17, 2007) was a mathematician specialising in convex sets, functional analysis, analysis of algorithms, optimization, and combinatorics. He spent almost his entire career at the University of Washington in Seattle.
Life
Born in San Francisco, Vic Klee earned his B.A. degree in 1945 with high honors from Pomona College, majoring in mathematics and chemistry. He did his graduate studies, including a thesis on Convex Sets in Linear Spaces, and received his PhD in mathematics from the University of Virginia in 1949. After teaching for several years at the University of Virginia, he moved in 1953 to the University of Washington in Seattle, Washington, where he was a faculty member for 54 years.
He died in Lakewood, Ohio.
Research
Klee wrote more than 240 research papers. He proposed Klee's measure problem and the art gallery problem. Kleetopes are also named after him, as is the Klee–Minty cube, which shows that the simplex algorithm for linear programming does not work in polynomial time in the worst–case scenario.
Service and recognition
Klee served as president of the Mathematical Association of America from 1971 to 1973. In 1972 he won a Lester R. Ford Award.
Notes
Further reading
Short biography, and reminiscences of colleagues.
External links
Applied Geometry and Discrete Mathematics a volume dedicated to Klee on his 65th birthday.
Brief obituary at the Mathematical Association of America (MAA)
AMS column: People |
https://en.wikipedia.org/wiki/Edna%20O.%20Simpson | Edna Oakes Simpson (October 26, 1891 – May 15, 1984) was a U.S. Representative from Illinois, wife of Sidney E. Simpson.
Born in Carrollton, Illinois, Edna
Simpson was elected as a Republican to the Eighty-sixth Congress (January 3, 1959 – January 3, 1961).
She did not seek renomination in 1960.
She was a resident of Carrollton, Illinois, until her death in Alton, Illinois, on May 15, 1984.
See also
Women in the United States House of Representatives
References
External links
1891 births
1984 deaths
Female members of the United States House of Representatives
Women in Illinois politics
Republican Party members of the United States House of Representatives from Illinois
20th-century American politicians
20th-century American women politicians
People from Carrollton, Illinois |
https://en.wikipedia.org/wiki/CGAL | The Computational Geometry Algorithms Library (CGAL) is an open source software library of computational geometry algorithms. While primarily written in C++, Scilab bindings and bindings generated with SWIG (supporting Python and Java for now) are also available.
The software is available under dual licensing scheme. When used for other open source software, it is available under open source licenses (LGPL or GPL depending on the component). In other cases commercial license may be purchased, under different options for academic/research and industrial customers.
History
The CGAL project was founded in 1996, as a consortium of eight research institutions in Europe and Israel:
Utrecht University, ETH Zurich, Free University of Berlin, INRIA Sophia Antipolis, Martin-Luther-University Halle-Wittenberg, Max Planck Institute for Informatics Saarbrücken, Johannes Kepler University Linz, and Tel-Aviv University. The original funding for the project came from the ESPRIT project of the European Union. Originally, its licensing terms allowed its software to be used freely for academic purposes, with commercial licenses available for other uses. CGAL Releases 3.x were distributed under the QPL license. Starting with CGAL 4.0, released in 2012, CGAL is distributed under the GPL version 3. it is managed by a thirteen-member editorial board, with an additional 30 developers and reviewers.
The project started in 1996 as the pooling of the previous efforts of several project participant |
https://en.wikipedia.org/wiki/Katrina%20%28given%20name%29 | Katrina or Katrine is a feminine given name. It is a derivative of Katherine.
People with this name include:
People
Katrina Adams (born 1968), American tennis player
Katrina Asay (born 1957), American politician
Katrina Bayonas (born 1941), English theatrical agent, producer and manager
Katrina Begin (born 1982), American actress
Katrina Best, British-born Canadian author of short stories
Katrina Bowden (born 1988), American actress
Katrina Boyd (born 1971), Australian soccer player
Katrina Brown, English academic
Katrina Bryan (born 1980), Scottish stage, film and television actress and CBeebies presenter
Katrina Carlson, American singer-songwriter
Katrina Jane Colebrook (born 1957), also known as Jane Colebrook, Jane Finch and Jane Weston, English track athlete
Katrina Colleton (born 1971), American basketball player
Katrina Conder, Australian television presenter
Katrina del Mar, American filmmaker and photographer
Katrina Devine (born 1980), New Zealand actor
Katrina Rose Dideriksen (born 1983), American actress
Katrina Dunn, Canadian actor and theatrical producer
Katrina Edwards (1968–2014) American geomicrobiologist
Katrina Elam (born 1983), American country music singer
Katrina Fong Lim (born 1961), Lord Mayor of Darwin, Australia
Katrina Forrester (born 1986), English political theorist and historian
Katrina Gibbs (born 1959), Australian track and field athlete
Katrine Gislinge (born 1969), Danish pianist
Katrina Gorry (born 1992), Australian |
https://en.wikipedia.org/wiki/Acoustic%20droplet%20ejection | Acoustic droplet ejection (ADE) uses a pulse of ultrasound to move low volumes of fluids (typically nanoliters or picoliters) without any physical contact. This technology focuses acoustic energy into a fluid sample in order to eject droplets as small as a picoliter. ADE technology is a very gentle process, and it can be used to transfer proteins, high molecular weight DNA and live cells without damage or loss of viability. This feature makes the technology suitable for a wide variety of applications including proteomics and cell-based assays.
History
Acoustic droplet ejection was first reported in 1927 by Robert W. Wood and Alfred Loomis, who noted that when a high-power acoustic generator was immersed in an oil bath, a mound formed on the surface of the oil and, like a “miniature volcano,” ejected a continuous stream of droplets. Ripples that appear in a glass of water placed on a loud speaker show that acoustic energy can be converted to kinetic energy in a fluid. If the sound is turned up enough, droplets will jump from the liquid. This technique was refined in the 1970s and 1980s by Xerox and IBM and other organizations to provide a single droplet on-demand for printing ink onto a page. Two California-based companies, EDC Biosystems Inc. and Labcyte Inc. (both now acquired by Beckman Coulter), exploit acoustic energy for two separate functions: 1) as a liquid transfer device and 2) as a device for liquid auditing.
Ejection mechanism
To eject a droplet, a transducer |
https://en.wikipedia.org/wiki/Visual%20descriptor | In computer vision, visual descriptors or image descriptors are descriptions of the visual features of the contents in images, videos, or algorithms or applications that produce such descriptions. They describe elementary characteristics such as the shape, the color, the texture or the motion, among others.
Introduction
As a result of the new communication technologies and the massive use of Internet in our society, the amount of audio-visual information available in digital format is increasing considerably. Therefore, it has been necessary to design some systems that allow us to describe the content of several types of multimedia information in order to search and classify them.
The audio-visual descriptors are in charge of the contents description. These descriptors have a good knowledge of the objects and events found in a video, image or audio and they allow the quick and efficient searches of the audio-visual content.
This system can be compared to the search engines for textual contents. Although it is certain, that it is relatively easy to find text with a computer, is much more difficult to find concrete audio and video parts. For instance, imagine somebody searching a scene of a happy person. The happiness is a feeling and it is not evident its shape, color and texture description in images.
The description of the audio-visual content is not a superficial task and it is essential for the effective use of this type of archives. The standardization system that dea |
https://en.wikipedia.org/wiki/List%20of%20metropolitan%20areas%20in%20Japan | This is a list of in Japan by population as defined by the Statistics Bureau of Japan (SBJ) and the Center for Spatial Information Service of the University of Tokyo. The region containing most of the people in Japan between Tokyo and Fukuoka is often called the Taiheiyō Belt.
Population Census
The Statistics Bureau of Japan (SBJ) defines a metropolitan area as one or more central cities and its associated outlying municipalities. To qualify as an outlying municipality, the municipality must have at least 1.5% of its resident population aged 15 and above commuting to school or work into one of the central cities. To qualify as a central city, a city must either be a designated city of any population or a non-designated city with a city proper population of at least 500,000. Metropolitan areas of designated cities are defined as "major metropolitan areas" (大都市圏) while those of non-designated cities are simply "metropolitan areas" (都市圏). If multiple central cities are close enough such that their outlying cities overlap, they are combined and a single metropolitan area is defined rather than independently.
2015 Population Census
The metropolitan areas written in bold are the 11 major metropolitan areas of Japan.
2015
MMA: Major Metropolitan Area
MA: Metropolitan Area
Source: Statistics Bureau of Japan
2010 Population Census
The metropolitan areas written in bold are the 11 major metropolitan areas of Japan.
2010
MMA: Major Metropolitan Area
MA: Metropolitan Area
Source: |
https://en.wikipedia.org/wiki/Biotransformation | Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds. Biotransformations can be conducted with whole cells, their lysates, or purified enzymes. Increasingly, biotransformations are effected with purified enzymes. Major industries and life-saving technologies depend on biotransformations.
Advantages and disadvantages
Compared to the conventional production of chemicals, biotransformations are often attractive because their selectivities can be high, limiting the coproduction of undesirable coproducts. Generally operating under mild temperatures and pressures in aqueous solutions, many biotransformations are "green". The catalysts, i.e. the enzymes, are amenable to improvement by genetic manipulation.
Biotechnology usually is restrained by substrate scope. Petrochemicals for example are often not amenable to biotransformations, especially on the scale required for some applications, e.g. fuels. Biotransformations can be slow and are often incompatible with high temperatures, which are employed in traditional chemical synthesis to increase rates. Enzymes are generally only stable <100 °C, and usually much lower. Enzymes, like other catalysts are poisonable. In some cases, performance or recyclability can be improved by using immobilized enzymes.
Historical
Wine and beer making are examples of biotransformations that have been practiced since ancient times. Vinegar has long been produced by fermentation, involv |
https://en.wikipedia.org/wiki/Avro%20552 | The Avro 552 was a British light biplane aircraft produced in the early 1920s. It was another attempt by Avro to sell a derivative of the wartime 504 to the civil market.
Design and development
In this case, the company took advantage of the large number of war-surplus Wolseley Viper engines left over from Royal Aircraft Factory S.E.5a production. In 1921, one of these was married to a standard 504K airframe for evaluation under the designation Avro 551. Trials proved encouraging, but an extra fuel tank was installed in the upper wing as a result of the Viper's higher rate of fuel consumption, and changes were also made to the aileron design.
This configuration went into production as the 552, with the Argentine Navy purchasing 12 examples of a float-equipped version, the 552A, which served as trainers until 1927. Two similar machines were purchased by Bulgaria.
In 1924, the Royal Canadian Air Force arranged for Canadian Vickers to purchase a licence to produce five landplanes and nine seaplane examples for use in forestry patrol. These differed from British-built aircraft by the use of U.S. Naval Aircraft Factory floats, and increased fuel tankage for extended range. One of the license-built seaplanes was fitted with a Wright engine and known in Canadian service as the Avro Wright. Licensed production was also undertaken by C.B. Field of Kingswood Knoll, Surrey, who built three aircraft from surplus components supplied by Avro. These were flown as banner tugs by Inca Avia |
https://en.wikipedia.org/wiki/Ecarin | Ecarin is an enzyme that is derived from the venom of the Indian saw-scaled viper, Echis carinatus, It is the primary reagent in the Ecarin clotting time test.
The venom of the saw-scaled viper, Echis carinatus, causes bleeding and eventually death. The venom contains a metalloprotease called ecarin that converts prothrombin to meizothrombin, a thrombin analog with increased esterase activity, and not to normal thrombin. Ecarin is a glycoprotein with unique metalloproteinase properties. It has a molecular weight of 56,000 and has been found to specifically activate only prothrombin due to its strict substrate specificity. To better understand the structure-function relationships of Ecarin, researchers need to know its primary structure. This understanding is crucial for gaining insight into the related functions of the glycoprotein. To compare the covalent structures of Ecarin and RVV-X, researchers have determined the complete cDNA sequence and translated protein sequence of Ecarin.
Determining the activity of the protein Ecarina is an important step in comprehending its role in initiating blood clotting. To accomplish this, researchers use a special substance called a chromogenic thrombin substrate, which is a molecule that can be cleaved by thrombin, a protein that is a critical player in the blood clotting cascade. The cleavage products that are generated by the substrate can be measured over time, and this parameter can be used to determine the activity of Ecarina.
T |
https://en.wikipedia.org/wiki/Fibroblast%20growth%20factor%20receptor%203 | Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location p16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys.
The FGFR3 gene produces various forms of the FGFR3 protein; the location varies depending on the isoform of the FGFR3 protein. Since the different forms are found within different tissues the protein is responsible for multiple growth factor interactions. Gain of function mutations in FGFR3 inhibits chondrocyte proliferation and underlies achondroplasia and hypochondroplasia.
Function
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals which ultimately influence cell mitogenesis and differentiation.
This particular family member binds both acidic and basic fibroblast growth factor and plays a role in bone de |
https://en.wikipedia.org/wiki/Chicago%20Bulls%20all-time%20roster | The following is a list of players, both past and current, who appeared at least in one game for the Chicago Bulls NBA franchise.
Players
Note: Statistics are correct through the end of the season.
A to B
|-
|align="left"| || align="center"|G || align="left"|Loyola Marymount || align="center"|2 || align="center"|– || 67 || 958 || 95 || 91 || 296 || 14.3 || 1.4 || 1.4 || 4.4 || align=center|
|-
|align="left"| || align="center"|F || align="left"|West Virginia || align="center"|1 || align="center"| || 8 || 29 || 5 || 2 || 4 || 3.6 || 0.6 || 0.3 || 0.5 || align=center|
|-
|align="left"| || align="center"|G || align="left"|Arizona || align="center"|1 || align="center"| || 10 || 120 || 26 || 13 || 37 || 12.0 || 2.6 || 1.3 || 3.7 || align=center|
|-
|align="left"| || align="center"|F/C || align="left"|Villanova || align="center"|2 || align="center"|– || 114 || 1,339 || 259 || 36 || 508 || 11.7 || 2.3 || 0.3 || 4.5 || align=center|
|-
|align="left"| || align="center"|F || align="left"|Wake Forest || align="center"|1 || align="center"| || 6 || 67 || 19 || 2 || 9 || 11.2 || 3.2 || 0.3 || 1.5 || align=center|
|-
|align="left"| || align="center"|F/C || align="left"|UNLV || align="center"|2 || align="center"|– || 2 || 3 || 1 || 0 || 0 || 1.5 || 0.5 || 0.0 || 0.0 || align=center|
|-
|align="left"| || align="center"|C || align="left"|Australia || align="center"|1 || align="center"| || 73 || 1,007 || 280 || 65 || 439 || 13.8 || 3.8 || 0.9 || 6.0 || align=center|
|-
|align="left"| || al |
https://en.wikipedia.org/wiki/Units%20of%20measurement%20in%20transportation | The units of measurement in transportation describes the unit of measurement used to express various transportation quantities, as used in statistics, planning, and their related applications.
Transportation quantity
The currently popular units are:
Length of journey
kilometre (km) or kilometer is a metric unit used, outside the US, to measure the length of a journey;
the international statute mile (mi) is used in the US; 1 mi = 1.609344 km
nautical mile is rarely used to derive units of transportation quantity.
Traffic flow
vehicle-kilometre (vkm) as a measure of traffic flow, determined by multiplying the number of vehicles on a given road or traffic network by the average length of their trips measured in kilometres.
vehicle-mile (, or VMT) same as before but measures the trip expressed in miles.
Passenger
Payload quantity
Passenger; Person (often abbreviated as either "pax" or "p.")
Passenger-distance
Passenger-distance is the distance (km or miles) travelled by passengers on transit vehicles; determined by multiplying the number of unlinked passenger trips by the average length of their trips.
passenger-kilometre or pkm internationally;
passenger-mile (or pmi ?) sometimes in the US; 1 pmi = 1.609344 pkm
Passengers per hour per direction
Passengers per hour per direction (pphpd) measures the maximum route capacity of a transport system.
Passengers per bus hour
A system may carry a high number of passengers per distance (km or mile) but a relatively l |
https://en.wikipedia.org/wiki/TCJ | TCJ may refer to:
Eiken (studio)
The Comics Journal
TCJ subsection at Cell junction
Tube CAD Journal (Online Publication)
Tree Climbing Japan (Outdoor activity) |
https://en.wikipedia.org/wiki/No%20More%20Ladies | No More Ladies is a 1935 American romantic comedy film directed by Edward H. Griffith. The film stars Joan Crawford and Robert Montgomery, and co-stars Charlie Ruggles, Franchot Tone, and Edna May Oliver. The screenplay credited to Donald Ogden Stewart and Horace Jackson is based on a stage comedy of the same name by A.E. Thomas.
Plot summary
Marcia (Joan Crawford) is a young socialite who shares her New York home with her grandmother, Fanny Townsend (Edna May Oliver). Marcia is a firm believer that a couple must be faithful to one another, unlike her peers who do not feel so strongly. Marcia meets Jim (Franchot Tone), who agrees with her on the subject of a couple's monogamy and pursues her. Marcia, however, decides to pursue Sherry (Robert Montgomery), whom Marcia sees as a challenge and seeks to cure him of his philandering and womanizing nature.
After a night at a club where some of Sherry's past flings swirl about him, the couple discuss the institution of marriage and have clearly divergent views. Despite this, Marcia and Sherry are married, yet Sherry continues as before. Even on their honeymoon, Sherry flirts with the gorgeous Sally French (Jean Chatburn). Later, when the newly married couple returns home, Sherry goes home with a friend's date, Theresa German (Gail Patrick), and doesn't return that night. Marcia realizes her philandering husband has already ruined their marriage. Sherry admits to spending the night with Theresa and admits his infidelity in a rather |
https://en.wikipedia.org/wiki/Inflatable%20building | An inflatable building is a structure constructed using two layers of membrane connected together, typically using spars made from the same material. The cavity formed between the layers is pressurized with air producing a rigid structural element which allows large span structures to be achieved. The key difference between air-supported buildings and inflatable buildings is that air-supported buildings require airlocks at all the access points to prevent air being lost when doors are opened since the entire occupied space of the building is pressurized. Inflatable buildings like this commonly serve sports, such as tennis and indoor golf.
Structure
An inflatable building only requires pressurized air within the cavities of the walls and so does not require airlocks since the occupied interior of the building is at normal atmospheric pressure.
The air contained within the walls of an inflatable building becomes a true structural part of the building. The membranes used in the construction of such buildings are typically less than 1mm thick, so the amount of membrane used compared to the volume of air contained within the walls is incredibly low (typically less than 0.5%). This makes inflatable buildings efficient in terms of the amount of raw materials required to construct them.
The small amount of material used in the construction of inflatable buildings makes them highly portable. When a building needs to be moved, the air can simply be allowed to escape enabling an en |
https://en.wikipedia.org/wiki/Zabar%2C%20Hungary | Zabar is a village in Nógrád county, Hungary.
Geography
Zabar lies about east of Salgótarján, where the borders of , and counties and Slovakia meet. The River Tarna (only a stream at this point) flows through the village. Kőverő-ér in the centre of the inner village is a small tributary to the Tarna.
The village has two physically separate parts, Belsőzabar ("Inner Zabar") and Külsőzabar ("Outer Zabar").
History
The name Zabar is of Slavic origin and its meaning approximates to "a place behind the pine forest." This etymology is somewhat of a mystery as pine is not an indigenous species in the area. Its first mention in an official document dates from 1332 (as ).
The village was abandoned during the Turkish occupation of the sixteenth and seventeenth centuries.
Tourism
The surroundings make it an optimal destination for hiking and hunting. Most of the hills are covered with forest, although deforestation has recently intensified on privately owned lands. Beech, oak, acacia and planted pine species are the most common.
Between May and September the forests are abundant with several kinds of edible mushroom, which inhabitants take full advantage of. They eat them and also sell them, mostly for export to France and Italy, and many locals treat it as a pastime.
Zabar has the coldest mean winter temperatures of all Hungary. In the ten years since temperatures have been recorded the lowest value was on 12 January 2003. (Although this is 3 °C (5 °F) warmer than the al |
https://en.wikipedia.org/wiki/Climate%20of%20Dallas | Dallas is located in North Texas, built along the Trinity River. It has a humid subtropical climate (Köppen climate classification: Cfa) that is characteristic of the southern plains of the United States. Dallas experiences mild winters and hot summers.
Seasonal climate
Summer
Summers are very hot and variably humid, with extended periods of hot, dry weather common in many summers. Wetter (generally less hot) periods occur in a minority of years. Heat waves can be severe and prolonged, usually coinciding with severe drought. During the summer, the greater Dallas area receives warm to hot, dry airflow from Southwestern desert areas to the west and southwest, as well as hot, humid air from the Gulf of Mexico. The city's all-time recorded high temperature is during the Heat Wave of 1980. In July and August, the average high temperature is near , while the average nighttime low temperature is around . Days with temperatures exceeding 100 °F (38 °C) happen at least several times during the summer every year. Especially hot and dry summers occurred in 1980, 2011, 2022 and 2023.
Transitional months
Spring and autumn bring warm weather to the area. Vibrant wildflowers (such as the bluebonnet, Indian paintbrush and other flora) bloom in spring and are planted around the highways throughout Texas. Springtime weather can be quite volatile, but temperatures themselves are warm on average. The weather in Dallas is also generally pleasant between late October and early December, an |
https://en.wikipedia.org/wiki/He%20Hit%20Me%20%28And%20It%20Felt%20Like%20a%20Kiss%29 | "He Hit Me (And It Felt Like a Kiss)" is a song written by Gerry Goffin and Carole King for girl group the Crystals under the guidance of Phil Spector in 1962. Goffin and King wrote the song after discovering that their babysitter and singer "Little Eva" Boyd was being regularly beaten by her boyfriend. When they inquired why she tolerated such treatment, Eva replied, with complete sincerity, that her boyfriend's actions were motivated by his love for her.
Production
Phil Spector's arrangement was ominous and ambiguous.
Release
Upon its initial release, "He Hit Me" received some airplay, but then there was a widespread protest of the song, with many concluding that the song was an endorsement of spousal abuse. Soon, the song was played only rarely on the radio, as now.
The 1930 Frank Borzage film Liliom contains the line "He hit me and it felt like a kiss" in its final scene. The film was not a success and nothing suggests that Goffin or King had seen it. Liliom, originally a play by Hungarian playwright Ferenc Molnár, was the basis for the Rodgers and Hammerstein musical classic, Carousel. While King and Goffin may not have seen Liliom, it is possible that they were familiar with the successful 1956 film version of Carousel, which contains essentially the same line. However, King has stated that Little Eva, their babysitter who inspired the song, had used that exact phrase to them.
Carole King, in that same radio interview, said that she was sorry she had ever had any |
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