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https://en.wikipedia.org/wiki/Liberty%20XL2
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The Liberty XL2 is a two-seat, low-wing, general aviation aircraft manufactured from 2004–2011 by Liberty Aerospace of Melbourne, Florida. A derivative of the Europa XS kit plane, it serves both as a touring aircraft for private flyers and as a flight trainer.
Subsequently, Discovery Aviation acquired the rights and in 2018 production of the aircraft (now named as the Discovery XL-2) resumed at the same Florida factory.
Design and development
Derived from the Europa XS kitplane and motor-glider, the XL-2 was type certified in 2004 under FAR Part 23 for VFR and IFR flight.
Compared to the Europa XS, the fuselage is slightly wider and larger to accommodate bigger American pilots, and also taller with a bigger windscreen. The wing is metal instead of composite and the aircraft is equipped with a Teledyne Continental Motors FADEC-controlled engine mounted on a metal space frame instead of the Europa's Rotax 912 engine mounted on the fiberglass fuselage. The landing gear is also of a different design.
The Liberty was designed by Ivan Shaw, who also created the Europa. The aircraft has a composite fuselage and aluminum wings. The engine is a fuel injected FADEC (Full Authority Digital Engine Control) equipped Continental IOF-240–B driving an MT composite propeller.
The landing gear is of tricycle configuration and all three sprung gear legs are made from 4130 chrome-molybdenum steel alloy. The nose wheel is free-castering. On early versions the nose wheel steering was by di
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https://en.wikipedia.org/wiki/Suprachoroid%20lamina
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The suprachoroid or suprachoroid lamina is a thin membrane forming part of the choroid of the eye. It lines the external surface of the choroid. It is composed of delicate non-vascular lamellae. The long and short ciliary nerves and the long posterior ciliary arteries pass anterior-ward within the suprachoroid lamina.
Anatomy
Microanatomy
The lamellae of the suprachoroid lamina are composed of a network of fine collagen and elastic fibers, and of fibroblasts and melanocytes.
The spaces between the lamellae are lined by endothelium, and open freely into the perichoroidal lymph space, which, in its turn, communicates with the periscleral space by the perforations in the sclera through which the vessels and nerves are transmitted.
Development
During embryological development, it is derived from the neural crest.
See also
suprachoroidal drug delivery
References
Human eye anatomy
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https://en.wikipedia.org/wiki/Branching%20theorem
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In mathematics, the branching theorem is a theorem about Riemann surfaces. Intuitively, it states that every non-constant holomorphic function is locally a polynomial.
Statement of the theorem
Let and be Riemann surfaces, and let be a non-constant holomorphic map. Fix a point and set . Then there exist and charts on and on such that
; and
is
This theorem gives rise to several definitions:
We call the multiplicity of at . Some authors denote this .
If , the point is called a branch point of .
If has no branch points, it is called unbranched. See also unramified morphism.
References
.
Theorems in complex analysis
Riemann surfaces
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https://en.wikipedia.org/wiki/List%20of%20U.S.%20Highways%20in%20Texas
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U.S. Highways in Texas are owned and maintained by the state. These U.S. Highways are the second-highest category of road classifications in the Texas road system, just below the Interstate Highways. U.S. Highways are marked with a number contained inside a white shield in a black box. The number is generally even if the highway runs east–west, and generally odd if it runs north–south, though there are many substantial deviations from this plan.
Mainline highways
Special routes
See also
References
Notes
External links
Texas Department of Transportation
Texas Highway Man
U.S.
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https://en.wikipedia.org/wiki/Clark%E2%80%93Ocone%20theorem
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In mathematics, the Clark–Ocone theorem (also known as the Clark–Ocone–Haussmann theorem or formula) is a theorem of stochastic analysis. It expresses the value of some function F defined on the classical Wiener space of continuous paths starting at the origin as the sum of its mean value and an Itô integral with respect to that path. It is named after the contributions of mathematicians J.M.C. Clark (1970), Daniel Ocone (1984) and U.G. Haussmann (1978).
Statement of the theorem
Let C0([0, T]; R) (or simply C0 for short) be classical Wiener space with Wiener measure γ. Let F : C0 → R be a BC1 function, i.e. F is bounded and Fréchet differentiable with bounded derivative DF : C0 → Lin(C0; R). Then
In the above
F(σ) is the value of the function F on some specific path of interest, σ;
the first integral,
is the expected value of F over the whole of Wiener space C0;
the second integral,
is an Itô integral;
Σ∗ is the natural filtration of Brownian motion B : [0, T] × Ω → R: Σt is the smallest σ-algebra containing all Bs−1(A) for times 0 ≤ s ≤ t and Borel sets A ⊆ R;
E[·|Σt] denotes conditional expectation with respect to the sigma algebra Σt;
∂/∂t denotes differentiation with respect to time t; ∇H denotes the H-gradient; hence, ∂/∂t∇H is the Malliavin derivative.
More generally, the conclusion holds for any F in L2(C0; R) that is differentiable in the sense of Malliavin.
Integration by parts on Wiener space
The Clark–Ocone theorem gives rise to an integration by p
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https://en.wikipedia.org/wiki/H-derivative
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In mathematics, the H-derivative is a notion of derivative in the study of abstract Wiener spaces and the Malliavin calculus.
Definition
Let be an abstract Wiener space, and suppose that is differentiable. Then the Fréchet derivative is a map
;
i.e., for , is an element of , the dual space to .
Therefore, define the -derivative at by
,
a continuous linear map on .
Define the -gradient by
.
That is, if denotes the adjoint of , we have .
See also
Malliavin derivative
References
Generalizations of the derivative
Measure theory
Stochastic calculus
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https://en.wikipedia.org/wiki/Gene%20delivery
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Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Gene delivery must reach the genome of the host cell to induce gene expression. Successful gene delivery requires the foreign gene delivery to remain stable within the host cell and can either integrate into the genome or replicate independently of it. This requires foreign DNA to be synthesized as part of a vector, which is designed to enter the desired host cell and deliver the transgene to that cell's genome. Vectors utilized as the method for gene delivery can be divided into two categories, recombinant viruses and synthetic vectors (viral and non-viral).
In complex multicellular eukaryotes (more specifically Weissmanists), if the transgene is incorporated into the host's germline cells, the resulting host cell can pass the transgene to its progeny. If the transgene is incorporated into somatic cells, the transgene will stay with the somatic cell line, and thus its host organism.
Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops. There are many different methods of gene delivery for various types of cells and tissues.
History
Viral based vectors emerged in the 1980s as a tool for transgene expression. In 1983, Albert Siegel described the use of viral vectors in plant transgene expression although viral manipulatio
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https://en.wikipedia.org/wiki/Partial%20specific%20volume
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The partial specific volume express the variation of the extensive volume of a mixture in respect to composition of the masses. It is the partial derivative of volume with respect to the mass of the component of interest.
where is the partial specific volume of a component defined as:
The PSV is usually measured in milliLiters (mL) per gram (g), proteins > 30 kDa can be assumed to have a partial specific volume of 0.708 mL/g. Experimental determination is possible by measuring the natural frequency of a U-shaped tube filled successively with air, buffer and protein solution.
Properties
The weighted sum of partial specific volumes of a mixture or solution is an inverse of density of the mixture namely the specific volume of the mixture.
See also
Partial molar property
Apparent molar property
References
Mass density
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https://en.wikipedia.org/wiki/Lighter%20fluid
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Lighter fluid or lighter fuel may refer to:
Butane, a highly flammable, colourless, easily liquefied gas used in gas-type lighters and butane torches
Naphtha, a volatile flammable liquid hydrocarbon mixture used in wick-type lighters and burners
Charcoal lighter fluid, an aliphatic petroleum solvent used in lighting charcoal in a barbecue grill
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https://en.wikipedia.org/wiki/M-12%20%28Michigan%20highway%29
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M-12 is a former state highway in the Upper Peninsula of Michigan. It was replaced in 1926 by:
U.S. Highway 2 in Michigan (US 2) between the state line at Ironwood and Crystal Falls
M-69 between Crystal Falls and Sagola
M-45 between Sagola and Iron Mountain (now M-95)
US 2 between Iron Mountain and Sault Ste. Marie
Since 1926, M-12 north of the St. Ignace area has been replaced by:
Business Loop Interstate 75 through St. Ignace
County Road H-63 to the Rogers Park area
M-134 to Cedarville
M-129 to Sault Ste. Marie
Business Spur Interstate 75 in Sault Ste. Marie
References
012
Transportation in Gogebic County, Michigan
Transportation in Iron County, Michigan
Transportation in Dickinson County, Michigan
Transportation in Menominee County, Michigan
Transportation in Delta County, Michigan
Transportation in Schoolcraft County, Michigan
Transportation in Mackinac County, Michigan
Transportation in Chippewa County, Michigan
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https://en.wikipedia.org/wiki/Excursion%20%28audio%29
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Excursion is defined as how far the cone of a speaker linearly travels from its resting position. Lower frequency drivers or subwoofers are designed to move more air and have more excursion than those of higher frequency. If a speaker is pushed beyond its limits, overexcursion, or "bottoming out," can occur as the voice coil either slips out of the magnetic gap or hits the bottom of it.
Often, large speakers such as those used in clubs and in professional audio actually allow little cone excursion and/or they have fairly stiff surrounds that do not allow them to fluctuate greatly without high power. This is because they would otherwise overdrive and have a much shorter lifetime because it doesn't take much power at very low frequencies to cause even a large and "powerful" loudspeaker to overfluctuate.
Extremes
The MTX Jackhammer, a 22-inch subwoofer made by MTX Audio, is capable of 2.5 inches of linear cone excursion, one way. That is a total range of 5 inches, which is potentially hazardous.
The Thunder 1000000, the record holder for the largest subwoofer ever made, with a diameter of 60 inches, is capable of 6 inches of peak to peak cone excursion.
See also
Power handling
Loudspeaker technology
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https://en.wikipedia.org/wiki/Levku%C5%A1ka
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Levkuška () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
https://web.archive.org/web/20080111223415/http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
Stub-Class Slovakia articles
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https://en.wikipedia.org/wiki/Luben%C3%ADk
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Lubeník () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
Lubenik.sk
https://web.archive.org/web/20070427022352/http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/PowerQUICC
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PowerQUICC is the name for several PowerPC- and Power ISA-based microcontrollers from Freescale Semiconductor. They are built around one or more PowerPC cores and the Communications Processor Module (QUICC Engine) which is a separate RISC core specialized in such tasks such as I/O, communications, ATM, security acceleration, networking and USB. Many components are System-on-a-chip designs tailor-made for embedded applications.
PowerQUICC processors are used in networking, automotive, industrial, storage, printing and consumer applications. Freescale are using PowerQUICC processors as a part of their mobileGT platform.
Freescale also manufactures QUICC microcontrollers based on the older 68k technology.
There are four distinct lines of processors, mainly based on processing power.
PowerQUICC I
The MPC8xx family was Motorola's first PowerPC based embedded processors, suited for network processors and system-on-a-chip devices. The core is an original implementation of the PowerPC specification. It is a single issue, four stage pipelined core with MMU and branch prediction unit with speeds up to 133 MHz. The MPC821 was introduced in 1995 together with MPC860 with a complete QUICC engine. A slimmed down version, MPC850 with reduced caches and IO ports came in 1997. The QUICC communication processor module (CPM) offloads networking tasks from the CPU, thus branding this family as PowerQUICC. All processors in the family differ in on-chip features like USB, serial, PCMCIA, ATM
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https://en.wikipedia.org/wiki/Plosk%C3%A9%2C%20Rev%C3%BAca%20District
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Ploské () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Skere%C5%A1ovo
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Skerešovo () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Ra%C5%A1ice
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Rašice () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Otro%C4%8Dok
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Otročok () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Rybn%C3%ADk%2C%20Rev%C3%BAca%20District
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Rybník () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/S%C3%A1sa%2C%20Rev%C3%BAca%20District
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Sása () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Tur%C4%8Dok
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Turčok () is a village and municipality in Revúca District in the Banská Bystrica Region of Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Revúca District
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https://en.wikipedia.org/wiki/Creed%20%28surname%29
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Creed is an English surname. At the time of the British Census of 1881, its frequency was highest in Somerset (7.4 times the British average), followed by Gloucestershire, Dorset, Kent, Oxfordshire, Norfolk, Warwickshire, London, Buckinghamshire and Wiltshire.
Notable people with the surname include:
Barbara Creed, cultural critic
Brutus Creed, ring name of professional wrestler Jacob Kasper
Consequences Creed (born 1986), early ring persona of American professional wrestler Austin Watson, now better known as Xavier Woods
Frederick G. Creed (1871–1957), Canadian inventor
Helios Creed, American musician, guitarist of Chrome
James Creed, MP for Canterbury
John Creed (politician) (1842–1930), Australian politician
John Creed (soldier) (1819–1872), Irish-American soldier
Julius Creed, ring name of professional wrestler Drew Kasper
Linda Creed (1949–1986), American songwriter
Martin Creed (born 1968), English artist
Michael Creed (born 1963), Irish politician
Percy Redfern Creed, Irish author
Sheldon Creed (born 1997), racing driver
Fictional characters
Adonis Creed, a boxer in the Rocky spin-off and sequel Creed
Apollo Creed, a boxer in the Rocky films
Graydon Creed, a Marvel Comics villain
Louis Creed, the protagonist of the Stephen King novel Pet Sematary
Victor Creed, a.k.a. Sabretooth, a Marvel Comics character
See also
Charlie Creed-Miles (born 1972), British actor
References
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https://en.wikipedia.org/wiki/Vieska%20nad%20Blhom
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Vieska nad Blhom () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Bis%28trimethylsilyl%29amine
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Bis(trimethylsilyl)amine (also known as hexamethyldisilazane and HMDS) is an organosilicon compound with the molecular formula [(CH3)3Si]2NH. The molecule is a derivative of ammonia with trimethylsilyl groups in place of two hydrogen atoms. An electron diffraction study shows that silicon-nitrogen bond length (173.5 pm) and Si-N-Si bond angle (125.5°) to be similar to disilazane (in which methyl groups are replaced by hydrogen atoms) suggesting that steric factors are not a factor in regulating angles in this case. This colorless liquid is a reagent and a precursor to bases that are popular in organic synthesis and organometallic chemistry. Additionally, HMDS is also increasingly used as molecular precursor in chemical vapor deposition techniques to deposit silicon carbonitride thin films or coatings.
Synthesis and derivatives
Bis(trimethylsilyl)amine is synthesized by treatment of trimethylsilyl chloride with ammonia:
2 (CH3)3SiCl + 3 NH3 → [(CH3)3Si]2NH + 2 NH4Cl
Ammonium nitrate together with triethylamine can be used instead. This method is also useful for 15N isotopic enrichment of HMDS.
Alkali metal bis(trimethylsilyl)amides result from the deprotonation of bis(trimethylsilyl)amine. For example, lithium bis(trimethylsilyl)amide (LiHMDS) is prepared using n-butyllithium:
[(CH3)3Si]2NH + BuLi → [(CH3)3Si]2NLi + BuH
LiHMDS and other similar derivatives: sodium bis(trimethylsilyl)amide (NaHMDS) and potassium bis(trimethylsilyl)amide (KHMDS) are used as a non-nucleophilic
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https://en.wikipedia.org/wiki/Diisopropylamine
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Diisopropylamine is a secondary amine with the chemical formula (Me2CH)2NH (Me = methyl). Diisopropylamine is a colorless liquid with an ammonia-like odor. Its lithium derivative, lithium diisopropylamide, known as LDA is a widely used reagent.
Reactions and use
Diisopropylamine is a common amine nucleophile in organic synthesis. Because it is bulky, it is a more selective nucleophile than, say, dimethylamine.
It reacts with organolithium reagents to give lithium diisopropylamide (LDA). LDA is a strong, non-nucleophilic base
The main commercial applications of diisopropylamine is as a precursor to two herbicides, diallate and triallate, as well as certain sulfenamides used in the vulcanization of rubber.
It is also used to prepare N,N-Diisopropylethylamine (Hünig's base) by alkylation with diethyl sulfate.
The bromide salt of diisopropylamine, diisopropylammonium bromide, is a room-temperature organic ferroelectric material.
Preparation
Diisopropylamine, which is commercially available, may be prepared by the reductive amination of acetone with ammonia using a modified copper oxide, generally copper chromite, as a catalyst:
Diisopropylamine can be dried by distillation from potassium hydroxide () or drying over sodium wire.
Toxicity
Causes burns by all exposure routes. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.
References
Alkylamines
Diisopropylamino compounds
Secondary amines
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https://en.wikipedia.org/wiki/Porfimer%20sodium
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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units. In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.
Porfimer is Haematoporphyrin Derivative (HpD) (See PDT).
Approvals and indications
It was approved in Canada in 1993 for the treatment of bladder cancer.
It was approved in Japan in 1994 (for early stage lung cancer?).
It was approved by the U.S. FDA in December 1995 for esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer.
In August 2003 the FDA approved its use for Barrett's esophagus.
References
External links
Photofrin
Photofrin marketing info
Side effects of PDT with Photofrin
History of Photofrin
Photosensitizing agents
Porphyrins
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https://en.wikipedia.org/wiki/Amsacrine
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Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent.
It has been used in acute lymphoblastic leukemia.
Mechanism
Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.
Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. In contrast, the structurally similar o-AMSA differing in the position of the methoxy substituent group on the anilino-ring have little ability to poison topoisomerase II despite its intercalative behavior, suggesting that intercalation of the molecule in itself is insufficient to trap topoisomerase II as a covalent complex on DNA.
References
Sulfonamides
Antineoplastic drugs
IARC Group 2B carcinogens
Acridines
O-methylated phenols
DNA intercalaters
Topoisomerase inhibitors
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https://en.wikipedia.org/wiki/Bexarotene
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Bexarotene, sold under the brand Targretin, is an antineoplastic (anti-cancer) agent used for the treatment of cutaneous T cell lymphoma (CTCL). It is a third-generation retinoid.
It was approved by the U.S. Food and Drug Administration (FDA) in December 1999, and the European Medicines Agency (EMA) in March 2001. It is available as a generic medication.
Medical uses
Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in people who are refractory to at least one prior systemic therapy (oral) and for the topical treatment of cutaneous lesions in patients with CTCL who have refractory or persistent disease after other therapies or who have not tolerated other therapies (topical).
It has been used off-label for non-small cell lung cancer and breast cancer.
Contraindications
Known contraindications include:
Hypersensitivity to the active substance or to any of the excipients in the preparation(s).
Pregnancy and lactation
Women of child-bearing potential without effective birth-control measures
History of pancreatitis
Uncontrolled hypercholesterolaemia
Uncontrolled hypertriglyceridaemia
Hypervitaminosis A
Uncontrolled thyroid disease
Hepatic insufficiency
Ongoing systemic infection
Adverse effects
Overall the most common adverse effects are skin reactions (mostly itchiness and rashes), leucopenia, headache, weakness, thyroid anomalies (which seem to be mediated by RXR-mediated downregulation of thyroid stimulating horm
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https://en.wikipedia.org/wiki/Denileukin%20diftitox
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Denileukin diftitox (trade name Ontak) was an antineoplastic agent, an engineered protein combining interleukin-2 and diphtheria toxin. Denileukin diftitox could bind to interleukin-2 receptors and introduce the diphtheria toxin into cells that express those receptors, killing the cells. In some leukemias and lymphomas, malignant cells express these receptors, so denileukin diftitox can target these.
In 1999, Ontak was approved by the U.S. Food and Drug Administration (FDA) for treatment of Cutaneous T-cell lymphoma (CTCL).
There is some evidence tying it to vision loss, and in 2006 the FDA added a black box warning to the drug's label.
In 2014, marketing of Ontak was discontinued in the US.
References
External links
FDA Safety Alert
Antineoplastic drugs
Diphtheria
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https://en.wikipedia.org/wiki/Brian%20D.%20Ripley
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Brian David Ripley FRSE (born 29 April 1952) is a British statistician. From 1990, he was professor of applied statistics at the University of Oxford and is also a professorial fellow at St Peter's College. He retired August 2014 due to ill health.
Biography
Ripley has made contributions to the fields of spatial statistics and pattern recognition. His work on artificial neural networks in the 1990s helped to bring aspects of machine learning and data mining to the attention of statistical audiences. He emphasised the value of robust statistics in his books Modern Applied Statistics with S and Pattern Recognition and Neural Networks.
Ripley helped develop the S programming language and its implementations: S-PLUS and R. He co-authored two books based on S, Modern Applied Statistics with S and S Programming. From 2000 to 2021 he was one of the most active committers to the R core.
He was educated at the University of Cambridge, where he was awarded both the Smith's Prize (at the time awarded to the best graduate essay writer who had been undergraduate at Cambridge in that cohort) and the Rollo Davidson Prize. The university also awarded him the Adams Prize in 1987 for an essay entitled Statistical Inference for Spatial Processes, later published as a book. He served on the faculty of Imperial College, London from 1976 until 1983, at which point he moved to the University of Strathclyde.
Authored books
Ripley, B. D. (1981) Spatial Statistics. Wiley, 252pp. .
Ripley, B. D.
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https://en.wikipedia.org/wiki/Spectral%20slope
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In astrophysics and planetary science, spectral slope, also called spectral gradient, is a measure of dependence of the reflectance on the wavelength.
In digital signal processing, it is a measure of how quickly the spectrum of an audio sound tails off towards the high frequencies, calculated using a linear regression.
Spectral slope in astrophysics and planetary science
The visible and infrared spectrum of the reflected sunlight is used to infer physical and chemical properties of the surface of a body. Some objects are brighter (reflect more) in longer wavelengths (red). Consequently, in visible light they will appear redder than objects showing no dependence of reflectance on the wavelength.
The diagram illustrates three slopes:
a red slope, the reflectance is increasing with the wavelengths
flat spectrum (in black)
And a blue slope, the reflectance actually diminishing with the wavelengths
The slope (spectral gradient) is defined as:
where is the reflectance measured with filters F0, F1 having the central wavelengths λ0 and λ1, respectively.
The slope is typically expressed in percentage increase of reflectance (i.e. reflexivity) per unit of wavelength: %/100 nm (or % /1000 Å)
The slope is mostly used in near infrared part of the spectrum while colour indices are commonly used in the visible part of the spectrum.
The trans-Neptunian object Sedna is a typical example of a body showing a steep red slope (20%/100 nm) while Orcus' spectrum appears flat in near infra-
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https://en.wikipedia.org/wiki/Tositumomab
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Tositumomab is a murine monoclonal antibody which targets the CD20 antigen produced in mammalian cell. It was combined with iodine-131 to produce a radiopharmaceutical for unsealed source radiotherapy, Iodine-131 Tositumomab (branded as Bexxar), for the treatment of non-Hodgkins lymphoma. It is classified as a IgG2a lambda antibody.
The drug combination was developed by Corixa which was purchased by GlaxoSmithKline in 2005. It was sold for about $25,000 for one round of treatment. Bexxar competed with Zevalin, until the former's discontinuation in 2014.
Clinical use
A personalized regimen using Bexxar was approved for the treatment of relapsed or chemotherapy/rituxan-refractory Non-Hodgkin lymphoma in 2003.
The radioactive dose was adjusted for each patient in order to maximize the radiation delivered to the tumor and minimize the exposure of other organs. Bexxar combined separate administration of unlabelled and iodine-labelled (i.e. covalently bonded to 131I) tositumomab. A first dose of labelled antibody was given once, and whole-body radiation was measured with a gamma camera over seven days. Analysis of that imaging data allowed an optimal dose of labelled antibody to be calculated, which was then administered once a day, for up to seven days. Each time the labelled antibody was administered, it was always preceded by unlabelled (non-radioactive) antibody. Early clinical trials had shown that total body residence times of radioactivity were longer in people who fir
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https://en.wikipedia.org/wiki/Palivizumab
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Palivizumab, sold under the brand name Synagis, is a monoclonal antibody produced by recombinant DNA technology used to prevent severe disease caused by respiratory syncytial virus (RSV) infections. It is recommended for infants at high-risk for RSV due to conditions such as prematurity or other medical problems including heart or lung diseases.
The most common side effects include fever and rash.
Palivizumab is a humanized monoclonal antibody (IgG) directed against an epitope in the A antigenic site of the F protein of RSV. In two phase III clinical trials in the pediatric population, palivizumab reduced the risk of hospitalization due to RSV infection by 55% and 45%. Palivizumab is dosed once a month via intramuscular (IM) injection, to be administered throughout the duration of the RSV season, which in based on past trends has started in Mid-September to Mid-November.
Palivizumab targets the fusion protein of RSV, inhibiting its entry into the cell and thereby preventing infection. Palivizumab was approved for medical use in 1998.
Medical use
Palivizumab is indicated for the prevention of serious lower respiratory tract disease requiring hospitalization caused by the respiratory syncytial virus (RSV) in children at high risk for RSV disease:
children born at 35 weeks of gestation or less and less than six months of age at the onset of the RSV season;
children less than two years of age and requiring treatment for bronchopulmonary dysplasia within the last six mont
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https://en.wikipedia.org/wiki/Mitochondrial%20trifunctional%20protein
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Mitochondrial trifunctional protein (MTP) is a protein attached to the inner mitochondrial membrane which catalyzes three out of the four steps in beta oxidation. MTP is a hetero-octamer composed of four alpha and four beta subunits:
HADHA
HADHB
The three functions are 2-enoyl coenzyme A (CoA) hydratase, long-chain 3-hydroxy acyl-coenzyme A dehydrogenase and long-chain 3-ketoacyl CoA thiolase.
Association with the electron transport chain
Fatty acid beta-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are two major metabolism pathways in the mitochondria. Reducing equivalents from FAO enter OXPHOS at the level of Complexes I and III. In 2010, Wang et al. discovered a functional and physical association between MTP and ETC respirasomes. Not only does MTP appear to be bound to Complex I, but it also appears to channel substrates between the two enzymes. This is especially interesting, because up until then it was unknown exactly how MTP was associated with the inner mitochondrial membrane, and this discovery may provide the explanation.
Hormonal influences
Recent research has revealed that MTP can be affected by various hormones, via hormone receptors located in the mitochondria. Chochron et al. (2012) demonstrated that thyroid hormone stimulates mitochondrial metabolism in a pathway mediated by MTP. Zhou et al. (2012) used 2D gel electrophoresis and mass spectrometry to identify MTP as one of the proteins that interacts with ER alpha, a receptor triggered by estro
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https://en.wikipedia.org/wiki/Manzanares%20el%20Real
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Manzanares el Real is a 8,936 inhabitant town (2020 statistics from ine.es) in the northern area of the autonomous Community of Madrid. It is located at the foot of The Pedriza, a part of the Sierra de Guadarrama, and next to the embalse de Santillana (the Santillana reservoir).
Main sights
The New Castle of Manzanares el Real, the best conserved castle in the Community of Madrid. Construction commencing in 1475, it has been used in several motion pictures, most notably El Cid.
The Old Castle of Manzanares el Real is the ruin of a former fortress, also known as Plaza de Armas. Only two walls remain standing, now integrated into a garden complex. It was built in Mudejar style of granite with brick curbing.
Church of Nuestra Señora de las Nieves, founded in the early 14th century. It has a nave and two aisles, separated by arcades on stone columns. The nave, in Romanesque styles, ends into a pentagonal presbytery. The church has also a 16th-century Renaissance portico.
Hermitage of Nuestra Señora de la Peña Sacra.
The Town Square and the Town Hall Houses - The Square has always been, and remains the place for celebrations, where local events, celebrations, and social life take place. The Town Hall Houses are peculiar because although our municipality was the head of the County of El Real de Manzanares, they did not exist as such: they were the County jail. It has always preserved its portico, the balcony, and its railings, a construction that may have been commissioned by t
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https://en.wikipedia.org/wiki/Buffer%20P2
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Buffer P2 is a lysis buffer solution produced by Qiagen. It contains 1% sodium dodecyl sulfate (SDS) (w/v) to puncture holes in cellular membranes, and 200mM NaOH. It is used in conjunction with other resuspension buffers and lysis buffers to release DNA from cells, often as part of the alkaline lysis method of purifying plasmid DNA from bacterial cell culture.
References
Cell biology
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https://en.wikipedia.org/wiki/Cellodextrin
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Cellodextrins are glucose polymers (polysaccharides) of varying length (two or more glucose monomers) resulting from cellulolysis, the breakdown of cellulose.
Classification
A cellodextrin is classified by its degree of polymerization (DP) which indicates the number of linked glucose monomers it contains. Each glucose monomer is linked via a beta-1,4 glycosidic bond. The most common cellodextrins are listed below:
cellobiose (DP=2) (sometimes not included in cellodextrin classification)
cellotriose (DP=3)
cellotetraose (DP=4)
cellopentaose (DP=5)
cellohexaose (DP=6)
Function
Cellodextrins are created through the cleavage of cellulose in most anaerobic bacteria by the cellulosome (an amalgamation of cellulolytic enzymes on the outside of a cell). An endoglucanase first cuts the crystalline cellulose in an amorphous zone and exoglucanases subsequently cleave these large insoluble chunks of cellulose into smaller, soluble cellodextrins which can be used by the cell.
Many cellulolytic bacteria use cellodextrins as their primary source of energy. The energy is obtained through the phosphorolytic cleavage of glycosidic bonds as well as the anaerobic glycolysis of the glucose monomers. Transport of cellodextrins across the cell membrane is usually an active process, requiring ATP.
See also
Dextrin breakdown of starch
References
Polysaccharides
Cellulose
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https://en.wikipedia.org/wiki/Lymphedema%E2%80%93distichiasis%20syndrome
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Lymphedema–distichiasis syndrome is a medical condition associated with the FOXC2 gene. People with this hereditary condition have a double row of eyelashes, which is called distichiasis, and a risk of swollen limbs due to problems in the lymphatic system.
Genetics
Lymphedema-distichiasis is inherited in an autosomal dominant fashion. It is estimated that only of diagnosed individuals did not inherit the condition but rather acquired the syndrome via a de novo mutation. Symptoms emerge between the life stages of puberty to early adulthood (around 30 years old). This is the result of a mutation in the FOXC2 gene.
Mutations
p.Y41F, a missense mutation, is also located in FOXC2 AD-1. p.Y41F is one of eleven mutations found in the FOXC2 gene. It was determined that of these 11 mutations, one was nonsense, six were missense, and four were frameshift mutations.
Symptoms
The main symptoms of lymphedema-distichiasis are limb swelling and a double row of eyelashes. Symptoms that have been noted in some but not all cases include cysts, light sensitivity, cardiac defects, cleft palate, and eye problems such as astigmatism and cornea scarring.
Syndrome diagnosis and management
Currently, the most accurate test to determine if an individual is affected by lymphedema-distichiasis syndrome is done via Sanger sequencing, which includes whole genome analysis and single gene and multigene testing. Sequenced DNA that exhibits mutations in the FOXC2 gene are considered confirmed clinic
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https://en.wikipedia.org/wiki/FOXC2
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Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.
Structure and function
The protein is 501 amino acids in length. The gene has no introns; the single exon is approximately 1.5kb in size.
FOX transcription factors are expressed during development and are associated with a number of cellular and developmental differentiation processes. FOXC2 is required during early development of the kidneys, including differentiation of podocytes and maturation of the glomerular basement membrane. It is also involved in the early development of the heart.
An increased expression of FOXC2 in adipocytes can increase the amount of brown adipose tissue leading to lower weight and an increased sensitivity to insulin.
Role in disease
Absence of FOXC2 has been shown to lead to the failure of lymphatic valves to form and problems with lymphatic remodelling. A number of mutations in the FOXC2 gene have been associated with Lymphedema–distichiasis syndrome, It has also been suggested that there may be a link between polymorphisms in FOXC2 and varicose veins.
FOXC2 is also involved in cancer metastases. In particular, expression of FOXC2 is induced when epithelial cells undergo an epithelial-mesenchymal transition (EMT) and become mesenchymal looking cells.
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https://en.wikipedia.org/wiki/Serre%27s%20conjecture
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Serre's conjecture may refer to:
Quillen–Suslin theorem, formerly known as Serre's conjecture
Serre's conjecture II (algebra), concerning the Galois cohomology of linear algebraic groups
Serre's modularity conjecture, concerning Galois representations
Serre's multiplicity conjectures in commutative algebra
Ribet's theorem, formerly known as Serre's epsilon conjecture
See also
Jean-Pierre Serre
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https://en.wikipedia.org/wiki/CKKQ-FM
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CKKQ-FM (100.3 The Q) is a broadcast radio station in Victoria, British Columbia, Canada. CKKQ broadcasts at a frequency of 100.3 MHz on the FM band. The station has broadcast a mainstream rock format since its inception, but has a more classic rock sound since 2001, when sister station CKXM AM/-FM became The Zone @ 91.3 with the CJZN calls and an alternative rock format. It used to have an adult album alternative lean up until Pattison took over the station from OK Radio.
The station placed 2nd in the fall 2018 Numeris Diary Survey for Victoria
History
In April 1987, the OK Radio Group Ltd. (known at the time as Victoria Communications Ltd.) was granted an FM radio license and launched 100.3 The Q, then known as Q-100, in December 1987. The first song played was The Rolling Stones' "Start Me Up".
In May 1999, CKKQ and sister station CKXM (formerly CKDA-AM) (now known as CJZN-FM (The Zone @ 91-3)) moved to the top floor of 2750 Quadra Street, a three-storey Victoria office building purchased by the OK Radio Group Ltd. in the fall of 1998.
Thanks to the prime position of CKKQ's transmitter on the Malahat Ridge, its signal reaches up Vancouver Island as far north as Nanaimo, onto the Lower Mainland as far east as Kent and into Washington as far south as Tacoma, on a good day. In 2000, CKKQ added a transmitter in Sooke on the frequency 94.7 FM with the callsign CKKQ-FM-1.
In 2001, CKKQ actually achieved a 0.1 share in the American Arbitron ratings for Seattle/Tacoma, placin
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https://en.wikipedia.org/wiki/Phytotoxicity
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Phytotoxicity describes any adverse effects on plant growth, physiology, or metabolism caused by a chemical substance, such as high levels of fertilizers, herbicides, heavy metals, or nanoparticles. General phytotoxic effects include altered plant metabolism, growth inhibition, or plant death. Changes to plant metabolism and growth are the result of disrupted physiological functioning, including inhibition of photosynthesis, water and nutrient uptake, cell division, or seed germination.
Fertilizers
High concentrations of mineral salts in solution within the plant growing medium can result in phytotoxicity, commonly caused by excessive application of fertilizers. For example, urea is used in agriculture as a nitrogenous fertilizer. However, if too much is applied, phytotoxic effects can result from urea toxicity directly or ammonia production from hydrolysis of urea. Organic fertilizers, such as compost, also have the potential to be phytotoxic if not sufficiently humified, as intermediate products of this process are harmful to plant growth.
Herbicides
Herbicides are designed and used to control unwanted plants such as agricultural weeds. However, the use of herbicides can cause phytotoxic effects on non-targeted plants through wind-blown spray drift or from the use of herbicide-contaminated material (such as straw or manure) being applied to the soil. Herbicides can also cause phytotoxicity in crops if applied incorrectly, in the wrong stage of crop growth, or in excess
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https://en.wikipedia.org/wiki/Friedrichs%27s%20inequality
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In mathematics, Friedrichs's inequality is a theorem of functional analysis, due to Kurt Friedrichs. It places a bound on the Lp norm of a function using Lp bounds on the weak derivatives of the function and the geometry of the domain, and can be used to show that certain norms on Sobolev spaces are equivalent. Friedrichs's inequality generalizes the Poincaré–Wirtinger inequality, which deals with the case k = 1.
Statement of the inequality
Let be a bounded subset of Euclidean space with diameter . Suppose that lies in the Sobolev space , i.e., and the trace of on the boundary is zero. Then
In the above
denotes the Lp norm;
α = (α1, ..., αn) is a multi-index with norm |α| = α1 + ... + αn;
Dαu is the mixed partial derivative
See also
Poincaré inequality
References
Sobolev spaces
Inequalities
Linear functionals
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https://en.wikipedia.org/wiki/Mason%27s%20theorem
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Mason's theorem may refer to either of the following:
The Mason–Stothers theorem, a mathematical theorem about polynomials
Mason's gain formula, a method for finding the transfer function of a linear signal-flow graph
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https://en.wikipedia.org/wiki/Crystal%20Lake%20%28Otter%20Tail%2C%20Minnesota%29
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Crystal Lake is a lake located in Lida Township in Otter Tail County, Minnesota, USA.
Size and shape
Crystal Lake is an almost circular lake, covering an area of and reaching a maximum depth of . Despite the said maximum depth, 51 percent of the lake is less than in depth.
Location
To the west is Lake Lizzie, which is connected to Crystal Lake by a navigable culvert under County Road 31. The larger Lake Lida lies close to the south of the lake, but is not connected directly. Smaller Lake Franklin is located to the northwest.
References
Lakes of Otter Tail County, Minnesota
Lakes of Minnesota
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https://en.wikipedia.org/wiki/Madrigueras
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Madrigueras is a municipality in Albacete, Castile-La Mancha, Spain. It has a population of 4,917 according to the official statistics by the National Statistics Institute of Spain (INE). The principal productions of this village are wine, knives and spatulas. Madrigueras is referred to as "Little China" due to the great number of inhabitants who use bikes for transportation.
References
External links
http://www.madrigueras.es Homepage of Madrigueras (in Spanish)
Municipalities of the Province of Albacete
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https://en.wikipedia.org/wiki/Lemke%20%28surname%29
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Lemke is a German surname.
Geographical distribution
As of 2014, 59.6% of all known bearers of the surname Lemke were residents of Germany (frequency 1:2,598), 27.7% of the United States (1:3,061,452), 4.6% of Brazil (1:86,475), 2.1% of Canada (1:33,211) and 2.1% of Poland (1:34,335).
In Germany, the frequency of the surname was higher than national average (1:2,598) in the following states:
1. Mecklenburg-Vorpommern (1:599)
2. Brandenburg (1:837)
3. Schleswig-Holstein (1:969)
4. Berlin (1:1,102)
5. Bremen (1:1,445)
6. Hamburg (1:1,642)
7. Lower Saxony (1:1,716)
8. Saxony-Anhalt (1:1,977)
People
Anthony Lemke, actor
Birsel Lemke, environmentalist
Carlton E. Lemke, mathematician
Helmut Lemke (1907-1990), German politician
James Lemke (born 1988), Australian professional tennis player
James U Lemke (1929–2019), American physicist and entrepreneur
Jay Lemke, education scientist
LeRoy Lemke (1935–1991), American lawyer and politician
Leslie Lemke, musical savant
Lev Lemke, actor
Mark Lemke, baseball player
Peter Henry Lemke, Benedictine
Richard R. Lemke (1930-2016), American farmer and politician
Siegfried Lemke, World War II Luftwaffe ace
Steffi Lemke (born 1968), German politician
Steve Lemke, guitar player
William Lemke, politician
Wolf Lemke, aircraft designer
Dave Lemke, original bass player of Imagine Dragons
References
German-language surnames
Surnames of German origin
de:Lemke (Begriffsklärung)
fr:Lemke
nl:Lemke
pl:Lemke
ru:Лемке
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https://en.wikipedia.org/wiki/List%20of%20Everton%20F.C.%20records%20and%20statistics
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Everton Football Club is a professional association football club located in Liverpool. The club was formed in 1878, and was originally named as St Domingo FC. The club's first game was a 1–0 victory over Everton Church Club. In November 1879 the club was renamed to Everton FC.
In 1888, Everton were one of the twelve founding members of the English Football League. The club have played in the top-flight of English Football for a record 117 years, having missed only four top-flight seasons (1930–31, 1951–52, 1952–53, 1953–54).
Major competitions won by Everton F.C., records set by the club, associated managers and players will be included in the following list.
The player records section includes: appearances, goals scored, and clean sheets kept. Player and manager awards, transfer fees, club records (Wins, Draws, and Losses) are all included in the list, as well as several others.
Honours
Domestic
First Division:
Titles (9): 1890–91, 1914–15, 1927–28, 1931–32, 1938–39, 1962–63, 1969–70, 1984–85, 1986–87
Second Division:
Titles (1): 1930–31
FA Cup:
Titles (5): 1905–06, 1932–33, 1965–66, 1983–84, 1994–95
Football League Cup:
Runner-up (2): 1976–77, 1983–84
FA Charity Shield:
Titles (9): 1928, 1932, 1963, 1970, 1984, 1985, 1986 (shared), 1987, 1995
Full Members Cup:
Runner-up (2): 1989, 1991
Football League Super Cup:
Runner-up (1): 1985–86
European
European Cup Winners' Cup:
Winners: (1): 1984–85
Doubles
1984–85: League and European Cup Winners' Cup
Awards
198
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https://en.wikipedia.org/wiki/Comparison%20theorem
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In mathematics, comparison theorems are theorems whose statement involves comparisons between various mathematical objects of the same type, and often occur in fields such as calculus, differential equations and Riemannian geometry.
Differential equations
In the theory of differential equations, comparison theorems assert particular properties of solutions of a differential equation (or of a system thereof), provided that an auxiliary equation/inequality (or a system thereof) possesses a certain property.
Chaplygin inequality
Grönwall's inequality, and its various generalizations, provides a comparison principle for the solutions of first-order ordinary differential equations.
Sturm comparison theorem
Aronson and Weinberger used a comparison theorem to characterize solutions to Fisher's equation, a reaction--diffusion equation.
Hille-Wintner comparison theorem
Riemannian geometry
In Riemannian geometry, it is a traditional name for a number of theorems that compare various metrics and provide various estimates in Riemannian geometry.
Rauch comparison theorem relates the sectional curvature of a Riemannian manifold to the rate at which its geodesics spread apart.
Toponogov's theorem
Myers's theorem
Hessian comparison theorem
Laplacian comparison theorem
Morse–Schoenberg comparison theorem
Berger comparison theorem, Rauch–Berger comparison theorem
Berger–Kazdan comparison theorem
Warner comparison theorem for lengths of N-Jacobi fields (N being a submanifold of a complet
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https://en.wikipedia.org/wiki/Separation%20theorem
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Separation theorem may refer to several theorems in different scientific fields.
Economics
Fisher separation theorem (corporation theory) - asserts that the objective of a corporation will be the maximization of its present value, regardless of the preferences of its shareholders.
Mutual fund separation theorem (portfolio theory) states that, under certain conditions, any investor's optimal portfolio can be constructed by holding each of certain mutual funds in appropriate ratios, where the number of mutual funds is smaller than the number of individual assets in the portfolio.
Mathematics
Gabbay's separation theorem (mathematical logic and computer science) states that any arbitrary temporal logic formula can be rewritten in a logically equivalent "past → future" form.
Planar separator theorem (graph theory) states that any planar graph can be split into smaller pieces by removing a small number of vertices.
Lusin's separation theorem (descriptive set theory) states that for any two disjoint analytic subsets of a Polish space there is a Borel subset containing one but disjoint from the other.
Geometry
Hyperplane separation theorem - either of two theorems about disjoint convex sets in n-dimensional Euclidean space. Also known as: Separating axis theorem.
Geometric separator theorems - theorems regarding the existence of lines separating objects in the plane without harming too many of them.
Guillotine separation theorems - theorems regarding the possibility of se
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https://en.wikipedia.org/wiki/Nunc
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Nunc A/S of Denmark was founded in 1953. Nunc specialized in laboratory plastic ware including products for cell culture, cell biology assays, sample prep, and sample storage. The company merged with the Nalge Company, which was founded in 1949 by chemist Emanuel Goldberg of Rochester, New York in 1995.
References
Manufacturing companies of Denmark
Companies based in Roskilde Municipality
Danish companies established in 1949
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https://en.wikipedia.org/wiki/Neporadza%2C%20Rimavsk%C3%A1%20Sobota%20District
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Neporadza () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Potok%2C%20Rimavsk%C3%A1%20Sobota%20District
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Potok () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Padarovce
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Padarovce (, also Balogpádár) is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
Municipalities in Slovakia where Hungarian is an official language
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https://en.wikipedia.org/wiki/Tachty
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Tachty () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rumince
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Rumince () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rakytn%C3%ADk
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Rakytník () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Valice
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Valice () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Vlky%C5%88a
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Vlkyňa () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Str%C3%A1nska
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Stránska () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Rimavsk%C3%A9%20Janovce
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Rimavské Janovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Transfersome
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Transfersome is a proprietary drug delivery technology, an artificial vesicle designed to exhibit the characteristics of a cell vesicle suitable for controlled and potentially targeted drug delivery. Some evidence has shown efficacy for its use for drug delivery without causing skin irritation, potentially being used to treat skin cancer. Transfersome is made by the German company IDEA AG.
References
Cell biology
Nanomedicine
Drug delivery devices
Dosage forms
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https://en.wikipedia.org/wiki/FDOA
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Frequency difference of arrival (FDOA) or differential Doppler (DD), is a technique analogous to TDOA for estimating the location of a radio emitter based on observations from other points. (It can also be used for estimating one's own position based on observations of multiple emitters). TDOA and FDOA are sometimes used together to improve location accuracy and the resulting estimates are somewhat independent. By combining TDOA and FDOA measurements, instantaneous geolocation can be performed in two dimensions.
It differs from TDOA in that the FDOA observation points must be in relative motion with respect to each other and the emitter. This relative motion results in different doppler shifts observations of the emitter at each location in general. The relative motion can be achieved by using airborne observations in aircraft, for example. The emitter location can then be estimated with knowledge of the observation points' location and vector velocities and the observed relative doppler shifts between pairs of locations.
A disadvantage of FDOA is that large amounts of data must be moved between observation points or to a central location to do the cross-correlation that is necessary to estimate the doppler shift.
The accuracy of the location estimate is related to the bandwidth of the emitter's signal, the signal-to-noise ratio at each observation point, and the geometry and vector velocities of the emitter and the observation points.
See also
Multilateration
Furthe
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https://en.wikipedia.org/wiki/Cryoablation
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Cryoablation is a process that uses extreme cold to destroy tissue. Cryoablation is performed using hollow needles (cryoprobes) through which cooled, thermally conductive, fluids are circulated. Cryoprobes are positioned adjacent to the target in such a way that the freezing process will destroy the diseased tissue. Once the probes are in place, the attached cryogenic freezing unit removes heat from ("cools") the tip of the probe and by extension from the surrounding tissues.
Ablation occurs in tissue that has been frozen by at least three mechanisms:
formation of ice crystals within cells thereby disrupting membranes, and interrupting cellular metabolism among other processes;
coagulation of blood thereby interrupting bloodflow to the tissue in turn causing ischemia and cell death; and
induction of apoptosis, the so-called programmed cell death cascade.
The most common application of cryoablation is to ablate solid tumors found in the lung, liver, breast, kidney and prostate. The use in prostate and renal cryoablation are the most common. Although sometimes applied in cryosurgery through laparoscopic or open surgical approaches, most often cryoablation is performed percutaneously (through the skin and into the target tissue containing the tumor) by a medical specialist, such as an interventional radiologist. The term is from cryo- + ablation.
Prostate
Prostate cryoablation is moderately effective but, as with any prostate removal process, also can result in impotence.
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https://en.wikipedia.org/wiki/List%20of%20towns%20and%20cities%20with%20100%2C000%20or%20more%20inhabitants
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By country name
A-B • C-D-E-F • G-H-I-J-K • L-M-N-O • P-Q-R-S • T-U-V-W-Y-Z
See also
List of largest cities
Notes
References
Sources
Population Density, United Nations Statistics Division, accessed 30 August 2010.
External links
Geopolis: research group, university of Paris-Diderot, France
Towns and cities with 100,000 or more inhabitants
100,000 or more inhabitants
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https://en.wikipedia.org/wiki/Nov%C3%A1%20Ba%C5%A1ta
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Nová Bašta () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Aiguilles%20Rouges
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The Aiguilles Rouges ("Red Needles") are a crystalline mountainous massif of the French Prealps, opposite the Mont Blanc Massif. The colour of the iron rich gneiss (metamorphique) mountains gives the range its name. The highest summit is the Aiguille du Belvédère at . At the southern end of the range, Le Brévent at is accessible by a cable car in the Planpraz and the Brévent sections.
Morphology
Unlike the massif of the Mont Blanc, the Aiguilles Rouges have no significant glaciers. The alpine stage begins around with rough boulders, above which a series of broken needles spring from the Col des Montets to Le Brévent. The northwestern side of the massif has less vegetation because of its lack of exposure to the sun. The southwest face abounds in vegetation which developed from a multitude of biotopes. Amongst the typical flora hikers can discover include sundews, martagons and many varieties of orchids. In order to protect this biodiversity, the Aiguilles Rouges National Nature Reserve (Réserve naturelle des aiguilles rouges) was created in 1974 covering 3,279 ha.
The Aiguilles Rouges offer a splendid view of all the peaks of Chamonix, the glaciers of Mont Blanc, and the roof of Europe. The French artist Samivel is known for his paintings of some of these splendid views. The highest point in this range is named Belvédère (literally "beautiful viewpoint" in French) because it offers a 360° panoramic view of all the mountains surrounding the Aiguilles Rouges. The mountai
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https://en.wikipedia.org/wiki/United%20Kingdom%20Standard%20Industrial%20Classification%20of%20Economic%20Activities
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The United Kingdom Standard Industrial Classification of Economic Activities (UKSIC) is a Standard Industrial Classification that is intended to help classify businesses according to the type of their economic activity. One or more SIC codes can be attributed to a business. SIC codes identify what a business does.
Over time there have been several different SIC systems used in the UK, with versions published in 1958, 1968, 1980, 1992, 1997, 2003 and 2007. These taxonomies have been adapted to cope with the changes in UK industry, The 1980 system was far more detailed in manufacturing, while the 2007 system is much stronger in the IT sector. Many companies still use the 2003 codes which were the 1992 system updated slightly. However, the very latest version is the 2007 SIC system
History
A Standard Industrial Classification (SIC) was first introduced into the United Kingdom in 1948 for use in classifying business establishments and other statistical units by the type of economic activity in which they are engaged. The classification provides a framework for the collection, tabulation, presentation and analysis of data and its use promotes uniformity. In addition, it can be used for administration purposes and by non-government bodies as a convenient way of classifying industrial activities into a common structure.
Current 2007 SIC codes
These now fall in line with the European Union industrial classification system, NACE, and the United Nations International Standard Indust
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https://en.wikipedia.org/wiki/Graef%20Crystal
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Graef "Bud" S. Crystal was an expert on executive compensation, often cited as a critic of excessive packages.
He started work as an executive compensation consultant in 1959. He worked for twenty years at the consulting firm Towers Perrin, and also taught at the Haas School of Business. He advised on pay at Coca-Cola Company and American Express.
He authored books on executive compensation as both an advisor and critic. He wrote a column on Bloomberg, and subsequently published on his own website.
Selected works
Compensating U.S. Executives Abroad (1972)
Executive Compensation: Money, Motivation, and Imagination (1978)
Financial Motivation For Executives (1978)
Questions and Answers on Executive Compensation: How to Get What You're Worth (1984)
In Search of Excess: The Overcompensation of American Executives (1991)
References
External links
The Crystal Report on Executive Compensation
Year of birth missing (living people)
Living people
American business writers
Haas School of Business faculty
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https://en.wikipedia.org/wiki/Nikon%20Coolpix%20S4
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The Coolpix S4 is a brand of digital camera produced by Nikon. Its image sensor is a CCD with 6.0 million pixels. It has a thin-film transistor liquid crystal display device with 110,000 pixels. The S4 incorporates Nikon's popular swivel design which allows the addition of a powerful Nikkor 10X Optical zoom lens, yet retain a compact form. Other features include D-Lighting and Face-priority AF.
Nikon later released the Nikon Coolpix S10 which has a similar 10x swivel lens design as the S4, but with more advanced features such as vibration reduction and a lithium ion battery.
See also
Nikon Coolpix S1
Nikon Coolpix S3
Nikon Coolpix S10
Nikon Coolpix 950
Nikon Coolpix 995
Nikon Coolpix 4500
References
"Nikon Coolpix S4"
External links
Nikon product archives: "Nikon Coolpix S4"
S0004
Digital cameras with CCD image sensor
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https://en.wikipedia.org/wiki/Rumble
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Rumble or Rumbling may refer to:
Companies
Rumble (company), video hosting service
Sounds and vibrations
Rumble (noise), a form of low frequency noise
Rumble, a haptic feedback vibration feature in video game controllers
Rumbling, a quality of a heart murmur
Stomach rumble, or borborygmus, a medical term
Places
Rumble, Shetland, an islet group off Whalsay, Scotland, UK
Rumble, Indiana, US
Rumble, West Virginia, US
People
Anthony Johnson (fighter), an American mixed martial artist nicknamed Rumble
Dane Rumble (born 1982), New Zealand recording artist
Darren Rumble (Australian rules footballer) (born 1984), Fremantle draftee
Darren Rumble (ice hockey) (born 1969), Canadian ice hockey player and coach
Mark Rumble, British television presenter on Studio Disney UK
Paul Rumble (born 1969), English footballer
Terry Rumble (born 1942), Australian politician
Tony Rumble (1956–1999), American professional wrestler
Mike Rumbles (born 1956), Scottish politician
Arts and entertainment
Films and television
Rumble (2002 film), a Finnish film directed by Jani Volanen
Rumble (2016 film), a Mexican film directed by R. Ellis Frazier
Rumble: The Indians Who Rocked the World, a 2017 Canadian documentary
Rumble (2021 film), an American film directed by Hamish Grieve
Rumble (TV series), a short-lived British sitcom; see 1995 in British television#BBC1
Music
Albums
The Rumble (Abhinanda album), 1999
The Rumble (N2Deep album), 1998
Songs
"Rumble", by KDA, later rew
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https://en.wikipedia.org/wiki/Dennis%20DeTurck
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Dennis M. DeTurck (born July 15, 1954) is an American mathematician known for his work in partial differential equations and Riemannian geometry, in particular contributions to the theory of the Ricci flow and the prescribed Ricci curvature problem. He first used the DeTurck trick to give an alternative proof of the short time existence of the Ricci flow, which has found other uses since then.
Education
DeTurck received a B.S. (1976) from Drexel University. He received an M.A. (1978) and Ph.D. (1980) in mathematics from the University of Pennsylvania. His Ph.D. supervisor was Jerry Kazdan.
Career
DeTurck is currently Robert A. Fox Leadership Professor and Professor of Mathematics at the University of Pennsylvania, where he has been the Dean of the College of Arts and Sciences since 2005 and Faculty Director of Riepe College House. In 2002, DeTurck won the Haimo Award from the Mathematical Association of America for his teaching. Despite being recognized for excellence in teaching, he has been criticized for his belief that fractions are "as obsolete as Roman numerals" and suggesting that they not be taught to younger students.
In January 2012, he shared the Chauvenet Prize with three mathematical collaborators. In 2012, he became a fellow of the American Mathematical Society.
Selected publications
(explains the DeTurck trick; also see the improved version)
References
External links
Article with some career and biographical info
Dennis DeTurck's homepage
1954 births
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https://en.wikipedia.org/wiki/The%20Crystal%20Palace%20%28novel%29
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The Crystal Palace is the second novel in "The Book of Elementals" series by Phyllis Eisenstein. (The first novel Sorcerer's Son was first published as a mass market paperback from Del Rey Books in 1979.) The Crystal Palace was originally released in 1988 as a mass-market paperback from Signet. It was last in-print in both hardcover and trade paperback in the 2002 omnibus volume The Book of Elementals (with Sorcerer's Son) from Meisha Merlin Publishing. (Eisenstein completed the manuscript for the final volume in the trilogy, The City in Stone, but the novel was left unpublished after Meisha Merlin suddenly ceased operations in 2007.)
Plot summary
Sorcerer Cray Ormoru and his friend, the seer Feldar Sepwin, craft an enchanted mirror that allows whoever gazes upon it to see their heart's desire. For Cray himself, the mirror remains blank for many years, until one day he sees in it the image of a young girl. With no idea of who she is, he watches the girl transform into a lovely woman over the years, and Cray realizes that he is destined to find her. When he does, he learns that this is Aliza, a sorceress who lives in a crystal palace which is partly within the demon realm and who is dedicated solely to the study of her craft.
Cray finds Aliza to be a skilled young sorceress, but also cold, aloof, and entirely focused on sorcery. Cray encourages her to take an interest in the outside world and forms a budding friendship. However, this friendship is strongly discouraged by Al
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https://en.wikipedia.org/wiki/Banana%20bag
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A banana bag (or rally pack) is a bag of IV fluids containing vitamins and minerals. The bags typically contain thiamine, folic acid, and magnesium sulfate, and are usually used to correct nutritional deficiencies or chemical imbalances in the human body. The solution has a yellow color, hence the term "banana bag".
A Banana Bag may also refer to an over the counter Banana Bag oral solution that is mixed with water and contains the same vitamins and electrolytes orally as the IV solution.
Composition
The typical composition of a banana bag is 1 liter of normal saline (sodium chloride 0.9%) with:
Thiamine 100 mg
Folic acid 1 mg
Multivitamin for infusion (MVI), 1 ampule
Magnesium sulfate 3 g
The solution is typically infused over four to eight hours or as per physician's orders. The yellow color comes from the riboflavin in the MVI and the folic acid. (The conventional composition is not optimal based on current evidence; see the Flannery et al. (2016) citation.)
Uses
Banana bags are often prescribed for alcoholics. Chronic alcoholism can lead to significant lack of thiamine, potentially causing Wernicke–Korsakoff syndrome. Chronic alcoholics can also suffer significant whole-body magnesium deficiencies. However, recent evidence (2016) points that the amount of thiamine in a conventional banana bag is inadequate for prophylaxis and treatment for ICU patients. The proposed regimen is 200–500 mg IV thiamine every eight hours for the first day of admission. Less evi
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https://en.wikipedia.org/wiki/Shallow%20trench%20isolation
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Shallow trench isolation (STI), also known as box isolation technique, is an integrated circuit feature which prevents electric current leakage between adjacent semiconductor device components. STI is generally used on CMOS process technology nodes of 250 nanometers and smaller. Older CMOS technologies and non-MOS technologies commonly use isolation based on LOCOS.
STI is created early during the semiconductor device fabrication process, before transistors are formed. The key steps of the STI process involve etching a pattern of trenches in the silicon, depositing one or more dielectric materials (such as silicon dioxide) to fill the trenches, and removing the excess dielectric using a technique such as chemical-mechanical planarization.
Certain semiconductor fabrication technologies also include deep trench isolation, a related feature often found in analog integrated circuits.
The effect of the trench edge has given rise to what has recently been termed the "reverse narrow channel effect" or "inverse narrow width effect". Basically, due to the electric field enhancement at the edge, it is easier to form a conducting channel (by inversion) at a lower voltage. The threshold voltage is effectively reduced for a narrower transistor width. The main concern for electronic devices is the resulting subthreshold leakage current, which is substantially larger after the threshold voltage reduction.
Process flow
Stack deposition (oxide + protective nitride)
Lithography print
Dry et
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https://en.wikipedia.org/wiki/NLRP3
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NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.
Nomenclature
NACHT, LRR, and PYD are respectively acronyms for:
NACHT – NAIP (neuronal apoptosis inhibitor protein), C2TA [class 2 transcription activator, of the MHC, HET-E (heterokaryon incompatibility) and TP1 (telomerase-associated protein 1)
LRR – "leucine-rich repeat" and is synonymous with NLR, for or nucleotide-binding domain, leucine-rich repeat"
PYD – "PYRIN domain," after the pyrin proteins The NLRP3 gene name abbreviates "NLR family, pyrin domain containing 3," where NLR refers to "nucleotide-binding domain, leucine-rich repeat."
The NACHT, LRR and PYD domains-containing protein 3 is also called:
cold induced autoinflammatory syndrome 1 (CIAS1),
caterpiller-like receptor 1.1 (CLR1.1), and
PYRIN-containing APAF1-like protein 1 (PYPAF1).
Structure
This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This pr
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https://en.wikipedia.org/wiki/Bombesin%20receptor
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The bombesin receptors are a group of G-protein coupled receptors which bind bombesin.
Three bombesin receptors are currently known:
BB1, previously known as Neuromedin B receptor
BB2, previously known as Gastrin-releasing peptide receptor
BB3, previously known as Bombesin-like receptor 3
External links
G protein-coupled receptors
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https://en.wikipedia.org/wiki/Calcitonin%20receptor
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The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.
CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).
Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.
Interactions
Calcitonin receptor has been shown to interact with Apolipoprotein B and LRP1.
References
Further reading
External links
G protein-coupled receptors
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https://en.wikipedia.org/wiki/Petrovce%2C%20Rimavsk%C3%A1%20Sobota%20District
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Petrovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Star%C3%A1%20Ba%C5%A1ta
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Stará Bašta () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Gromov%27s%20compactness%20theorem%20%28geometry%29
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In the mathematical field of metric geometry, Mikhael Gromov proved a fundamental compactness theorem for sequences of metric spaces. In the special case of Riemannian manifolds, the key assumption of his compactness theorem is automatically satisfied under an assumption on Ricci curvature. These theorems have been widely used in the fields of geometric group theory and Riemannian geometry.
Metric compactness theorem
The Gromov–Hausdorff distance defines a notion of distance between any two metric spaces, thereby setting up the concept of a sequence of metric spaces which converges to another metric space. This is known as Gromov–Hausdorff convergence. Gromov found a condition on a sequence of compact metric spaces which ensures that a subsequence converges to some metric space relative to the Gromov–Hausdorff distance:
Let be a sequence of compact metric spaces with uniformly bounded diameter. Suppose that for every positive number there is a natural number and, for every , the set can be covered by metric balls of radius . Then the sequence has a subsequence which converges relative to the Gromov–Hausdorff distance.
The role of this theorem in the theory of Gromov–Hausdorff convergence may be considered as analogous to the role of the Arzelà–Ascoli theorem in the theory of uniform convergence. Gromov first formally introduced it in his 1981 resolution of the Milnor–Wolf conjecture in the field of geometric group theory, where he applied it to define the asymptotic co
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https://en.wikipedia.org/wiki/Gromov%27s%20compactness%20theorem%20%28topology%29
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In the mathematical field of symplectic topology, Gromov's compactness theorem states that a sequence of pseudoholomorphic curves in an almost complex manifold with a uniform energy bound must have a subsequence which limits to a pseudoholomorphic curve which may have nodes or (a finite tree of) "bubbles". A bubble is a holomorphic sphere which has a transverse intersection with the rest of the curve. This theorem, and its generalizations to punctured pseudoholomorphic curves, underlies the compactness results for flow lines in Floer homology and symplectic field theory.
If the complex structures on the curves in the sequence do not vary, only bubbles can occur; nodes can occur only if the complex structures on the domain are allowed to vary. Usually, the energy bound is achieved by considering a symplectic manifold with compatible almost-complex structure as the target, and assuming that curves to lie in a fixed homology class in the target. This is because the energy of such a pseudoholomorphic curve is given by the integral of the target symplectic form over the curve, and thus by evaluating the cohomology class of that symplectic form on the homology class of the curve. The finiteness of the bubble tree follows from (positive) lower bounds on the energy contributed by a holomorphic sphere.
References
Symplectic topology
Compactness theorems
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https://en.wikipedia.org/wiki/Daz%20Eden
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Daz Eden is a fictional character from the British ITV soap opera Emmerdale, played by Luke Tittensor. He made his first appearance in the show on 9 October 2003. Six years into his tenure on the soap, it was announced that Tittensor had been released from Emmerdale due to a conviction of grievous bodily harm. Following a meeting with the show's bosses, the decision was taken to terminate Tittensor's contract due to the serious nature of the charge and to allow him to focus on the court case.
Casting
Luke Tittensor was cast as Daz and made his first appearance in October 2003. At the age of 19, Tittensor was charged with grievous bodily harm after he attacked a 16-year-old. Since he pleaded guilty to the crime and due to the serious nature of the charge, ITV felt they "had no choice but to let the actor go". ITV also wanted to "enable him to focus on the court case". In a statement, ITV said: "As Luke has pleaded guilty to the serious charge of GBH and we cannot condone criminal behaviour, we have met with Luke and his agent to explain his contract with Emmerdale will be terminated. Luke regrets his behaviour and understands this situation." Jess Grieveson-Smith of Leeds Live wrote that ITV's sacking had been "unceremonious". His final scenes aired on 24 April 2009.
Storylines
Daz was initially a troublemaker as he had a history of stealing cars but tried to make amends with community service. Unfortunately, things didn't go according to plan. Katie used this to her advant
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https://en.wikipedia.org/wiki/Etynodiol
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Etynodiol, or ethynodiol, is a steroidal progestin of the 19-nortestosterone group which was never marketed. A diacylated derivative, etynodiol diacetate, is used as a hormonal contraceptive. Etynodiol is sometimes used as a synonym for etynodiol diacetate.
It was patented in 1955.
Pharmacology
Etynodiol is a prodrug of norethisterone, and is converted immediately and completely into norethisterone. Etynodiol is an intermediate in the conversion of the prodrug lynestrenol into norethisterone.
Chemistry
Etynodiol is a 19-nortestosterone derivative. Structurally, it is almost identical to norethisterone and lynestrenol, differing only in its C3 substituent. Whereas norethisterone has a ketone at C3 and lynestrenol has no substituent at C3, etynodiol has a hydroxyl group at the position.
Synthesis
Society and culture
Generic names
Etynodiol is the generic name of the drug and its , while ethynodiol is its .
References
Ethynyl compounds
Androgens and anabolic steroids
Diols
Estranes
Prodrugs
Progestogens
Synthetic estrogens
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https://en.wikipedia.org/wiki/Medroxyprogesterone
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Medroxyprogesterone (MP), is a progestin which is not used medically. A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.
Pharmacology
Pharmacodynamics
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.
Chemistry
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position. The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol.
Society and culture
Generic names
Medroxyprogesterone is the generic name of the drug and its and .
Brand Name
Meprate 10 Tablets (practo)
References
Abandoned drugs
Tertiary alcohols
Alkene derivatives
Diketones
Pregnanes
Proges
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https://en.wikipedia.org/wiki/Doun%20Kaev%20%28town%29
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Doun Kaev ( ; lit. "Crystal Grandmother") is the capital of Takéo Province, Cambodia. In 1998 it had a population of 39,186. The town and province is known for silk weaving, and the province is home to about 10,000 of the total of 15,000 Cambodian weavers. Most silk weavers in the villages are near the national highway in the direction of Takéo town. The technique of silk weaving could have come to the Khmer during the Kingdom of Funan, probably in the 2nd century, from India and China.
Notable people
Pen Sovan (1936–2016), former Prime Minister of Cambodia
Chinary Ung (born 1942), composer
References
Populated places in Takéo province
Provincial capitals in Cambodia
Cities in Cambodia
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https://en.wikipedia.org/wiki/Equilibrium%20unfolding
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In biochemistry, equilibrium unfolding is the process of unfolding a protein or RNA molecule by gradually changing its environment, such as by changing the temperature or pressure, pH, adding chemical denaturants, or applying force as with an atomic force microscope tip. If the equilibrium was maintained at all steps, the process theoretically should be reversible during equilibrium folding. Equilibrium unfolding can be used to determine the thermodynamic stability of the protein or RNA structure, i.e. free energy difference between the folded and unfolded states.
Theoretical background
In its simplest form, equilibrium unfolding assumes that the molecule may belong to only two thermodynamic states, the folded state (typically denoted N for "native" state) and the unfolded state (typically denoted U). This "all-or-none" model of protein folding was first proposed by Tim Anson in 1945, but is believed to hold only for small, single structural domains of proteins (Jackson, 1998); larger domains and multi-domain proteins often exhibit intermediate states. As usual in statistical mechanics, these states correspond to ensembles of molecular conformations, not just one conformation.
The molecule may transition between the native and unfolded states according to a simple kinetic model
N U
with rate constants and for the folding (U -> N) and unfolding (N -> U) reactions, respectively. The dimensionless equilibrium constant can be used to determine the conformational stabi
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https://en.wikipedia.org/wiki/Flow%20birefringence
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In biochemistry, flow birefringence is a hydrodynamic technique for measuring the rotational diffusion constants (or, equivalently, the rotational drag coefficients). The birefringence of a solution sandwiched between two concentric cylinders is measured as a function of the difference in rotational speed between the inner and outer cylinders. The flow tends to orient an ellipsoidal particle (typically, a protein, virus, etc.) in one direction, whereas rotational diffusion (tumbling) causes the molecule to become disoriented. The equilibrium between these two processes as a function of the flow provides a measure of the axial ratio of the ellipsoidal particle.
See also
Perrin friction factors
Protein structure
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https://en.wikipedia.org/wiki/Vorozole
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Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.
References
Aromatase inhibitors
Benzotriazoles
Chloroarenes
Triazoles
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https://en.wikipedia.org/wiki/List%20of%20municipalities%20in%20Rio%20Grande%20do%20Norte
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Rio Grande do Norte () is a state located in the Northeast Region of Brazil. According to the 2010 Census conducted by the Brazilian Institute of Geography and Statistics (IBGE), Rio Grande do Norte has a population of 3,168,133 inhabitants over , which makes it the 16th largest state by population and the 22nd largest by area, out of 26 states. It is home to cities such as Natal, Mossoró, and São Gonçalo do Amarante.
The land that became Rio Grande do Norte was a donatário to João de Barros, the factor of the House of India and Mina, from John III of Portugal in 1535; prior to that, the Portuguese Crown owned the land. The French, who trafficked Brazil wood in the area, had a foothold on the land until the Portuguese expelled them in 1598. The Dutch took the land in 1634 as a part of Dutch Brazil and reigned until 1654, when they were defeated by the Portuguese. In 1701, Rio Grande do Norte joined the Captaincy of Pernambuco, and became a province in 1822 and a state of Brazil in 1889.
Rio Grande do Norte is divided into 167 municipalities, which are grouped into four mesoregions and 23 microregions. Of the 167 municipalities, Natal has the highest population, with 803,811 inhabitants, while Viçosa, with 1,618 inhabitants, has the lowest. The largest municipality by area is Mossoró, with an area of ; the smallest is Senador Georgino Avelino, named after the former Senator and Rio Grande do Norte Governor José Georgino Avelino, which covers an area of .
Municipalities
See
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https://en.wikipedia.org/wiki/Mark%20N.%20Wegman
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Mark N. Wegman is an American computer scientist known for his contributions to algorithms and compiler optimization. Wegman received his B.A. from New York University and his Ph.D. from the University of California, Berkeley. He joined IBM Research in 1975, where he currently serves as head of Computer Science. He is a member of the IBM Academy of Technology and a Fellow of the Association for Computing Machinery (1996) and the Institute of Electrical and Electronics Engineers. He became an IBM Fellow in 2007. He was elected to the National Academy of Engineering in 2010.
Wegman is best known for being one of the inventors of the Static single assignment form, which is used in the analysis portion of most if not all modern optimizing compilers. This work was recognized by SIGPLAN in 2006 with its Programming Languages Achievement Award. He has also made contributions to algorithms and information theory including universal hashing and the LZMW data compression algorithm.
References
External links
IBM profile
American computer scientists
IBM employees
Fellows of the Association for Computing Machinery
Fellow Members of the IEEE
IBM Fellows
Members of the United States National Academy of Engineering
Living people
IBM Research computer scientists
Year of birth missing (living people)
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https://en.wikipedia.org/wiki/Tower%20rule
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The tower rule may refer to one of two rules in mathematics:
Law of total expectation, in probability and stochastic theory
a rule governing the degree of a field extension of a field extension in field theory
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https://en.wikipedia.org/wiki/Extensor%20retinaculum%20of%20the%20hand
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The extensor retinaculum (dorsal carpal ligament, or posterior annular ligament) is a thickened portion of the antebrachial fascia that holds the tendons of the extensor muscles in place. It is located on the back of the forearm, just proximal to the hand. It is continuous with the palmar carpal ligament (which is located on the anterior side of the forearm).
Structure
The extensor retinaculum is a strong, fibrous band, extending obliquely downward and medialward across the back of the wrist. It consists of part of the deep fascia of the back of the forearm, strengthened by the addition of some transverse fibers.
Relations
There are six separate synovial sheaths run beneath the extensor retinaculum: (1st) abductor pollicis longus and extensor pollicis brevis tendons, (2nd) extensor carpi radialis lungus and brevis tendons, (3rd) extensor pollicis longus tendon, (4th) extensor digitorium communis and extensor indicis proprius tendons, (5th) extensor digiti minimi tendon and (6th) extensor carpi ulnaris tendon.
On the dorsal side of the hand, the palmar carpal ligament corresponds in location and structure to the extensor retinaculum, both being formations of the antebrachial fascia and therefore continuous. Consequently, the flexor retinaculum is commonly referred to as the transverse carpal ligament to avoid confusion.
Histology
Structurally, the retinaculum consists of three layers. The deepest layer, the gliding layer, consists of hyaluronic acid-secreting cells. The
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https://en.wikipedia.org/wiki/DrawPlus
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DrawPlus is a 2D vector graphics editor and animation software developed by the UK-based software company Serif, also responsible for PhotoPlus, PagePlus, WebPlus, Digital Scrapbook Artist, Affinity Designer, Affinity Photo and other titles.
Serif have ceased development of DrawPlus in order to focus on its successor, Affinity Designer, following its release for Windows.
In addition to traditional vector drawing tools, DrawPlus provides realistic, natural-looking brushes that allow the user to paint with watercolours, oils and other media whilst retaining vector editing capability. DrawPlus is also able to produce Stop frame and Key frame animations, including output to Adobe Flash swf file format and support for ActionScript.
DrawPlus X8 and Starter Edition offer support for pressure-sensitive input devices such as Wacom's range of tablets. Both applications feature a Pressure Studio to allow calibration of the individual devices and allow functions to be mapped to the supported buttons on the tablet. DrawPlus supports pressure-sensitive vector lines and brushes to create a striking range of effects from manga through to painting in an array of media.
DrawPlus is available both as a paid-for version, DrawPlus X8, or as a cut-down Starter Edition which is completely free. Both variants support SVG import and export to provide compatibility with other vector editing software.
Supported platforms
DrawPlus was developed for Linux and Microsoft Windows and is fully compatib
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https://en.wikipedia.org/wiki/Sample-continuous%20process
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In mathematics, a sample-continuous process is a stochastic process whose sample paths are almost surely continuous functions.
Definition
Let (Ω, Σ, P) be a probability space. Let X : I × Ω → S be a stochastic process, where the index set I and state space S are both topological spaces. Then the process X is called sample-continuous (or almost surely continuous, or simply continuous) if the map X(ω) : I → S is continuous as a function of topological spaces for P-almost all ω in Ω.
In many examples, the index set I is an interval of time, [0, T] or [0, +∞), and the state space S is the real line or n-dimensional Euclidean space Rn.
Examples
Brownian motion (the Wiener process) on Euclidean space is sample-continuous.
For "nice" parameters of the equations, solutions to stochastic differential equations are sample-continuous. See the existence and uniqueness theorem in the stochastic differential equations article for some sufficient conditions to ensure sample continuity.
The process X : [0, +∞) × Ω → R that makes equiprobable jumps up or down every unit time according to
is not sample-continuous. In fact, it is surely discontinuous.
Properties
For sample-continuous processes, the finite-dimensional distributions determine the law, and vice versa.
See also
Continuous stochastic process
References
Stochastic processes
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https://en.wikipedia.org/wiki/Kolmogorov%20extension%20theorem
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In mathematics, the Kolmogorov extension theorem (also known as Kolmogorov existence theorem, the Kolmogorov consistency theorem or the Daniell-Kolmogorov theorem) is a theorem that guarantees that a suitably "consistent" collection of finite-dimensional distributions will define a stochastic process. It is credited to the English mathematician Percy John Daniell and the Russian mathematician Andrey Nikolaevich Kolmogorov.
Statement of the theorem
Let denote some interval (thought of as "time"), and let . For each and finite sequence of distinct times , let be a probability measure on Suppose that these measures satisfy two consistency conditions:
1. for all permutations of and measurable sets ,
2. for all measurable sets ,
Then there exists a probability space and a stochastic process such that
for all , and measurable sets , i.e. has as its finite-dimensional distributions relative to times .
In fact, it is always possible to take as the underlying probability space and to take for the canonical process . Therefore, an alternative way of stating Kolmogorov's extension theorem is that, provided that the above consistency conditions hold, there exists a (unique) measure on with marginals for any finite collection of times . Kolmogorov's extension theorem applies when is uncountable, but the price to pay
for this level of generality is that the measure is only defined on the product σ-algebra of , which is not very rich.
Explanation of the conditions
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https://en.wikipedia.org/wiki/HSF
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HSF may refer to:
Hazara Student Federation, in Pakistan
Heat shock factor, a protein transcription factor
Human Social Functioning
Hellenic Sailing Federation, Greece
Herbert Smith Freehills, a law firm
Home Service Force, of the British Army
Homer Stryker Field, a stadium in Kalamazoo, Michigan, United States
Houston Shakespeare Festival, Texas, US
IATA code of Suifenhe Airport
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https://en.wikipedia.org/wiki/Disk%20diffusion%20test
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The disk diffusion test (also known as the agar diffusion test, Kirby–Bauer test, disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test and KB test) is a culture-based microbiology assay used in diagnostic and drug discovery laboratories. In diagnostic labs, the assay is used to determine the susceptibility of bacteria isolated from a patient's infection to clinically approved antibiotics. This allows physicians to prescribe the most appropriate antibiotic treatment. In drug discovery labs, especially bioprospecting labs, the assay is used to screen biological material (e.g. plant extracts, bacterial fermentation broths) and drug candidates for antibacterial activity. When bioprospecting, the assay can be performed with paired strains of bacteria to achieve dereplication and provisionally identify antibacterial mechanism of action.
In diagnostic laboratories, the test is performed by inoculating the surface of an agar plate with bacteria isolated from a patient's infection. Antibiotic-containing paper disks are then applied to the agar and the plate is incubated. If an antibiotic stops the bacteria from growing or kills the bacteria, there will be an area around the disk where the bacteria have not grown enough to be visible. This is called a zone of inhibition. The susceptibility of the bacterial isolate to each antibiotic can then be semi-quantified by comparing the size of these zones of inhibition to databases of information on
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https://en.wikipedia.org/wiki/TCGA
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TCGA may refer to:
The Cancer Genome Atlas
The Center for Genetic Anthropology at University College London
Taxation of Chargeable Gains Act 1992
Thomas Cook Group Airlines Limited - entered compulsory liquidation 23 September 2019
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https://en.wikipedia.org/wiki/Italian%20society%20of%20economics%20demography%20and%20statistics
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The Italian society of economics demography and statistics (SIEDS, ) is a learned society aiming to further economic, demographic, and statistical studies and to establish active co-operation among professionals of the mentioned subjects in the field of social sciences and human behaviour. The society pursues this aim by:
organising seminars, congresses, or scientific meetings for analysing and discussing problems concerning its activity;
implementing scientific surveys, enquires and researches and promoting, training activities (courses, seminars, etc.);
publishing the Rivista italiana di economia demografia e statistica, a series of studies and monographs on specific items concerning the scientific interest of the society, as well as the proceedings of its congresses and seminars.
History
SIEDS was founded on June 29, 1939, at the initiative of Livio Livi and others. The first seat of the society was located in Florence. Initially named "Italian Society of Demography and Statistics", it originated in the Advisory Committee for the Population Study (), also founded by Livi. The first publications of the society were only the scientific meeting proceedings but, starting from January 1947, the society published its own scientific journal, the Rivista italiana di economia demografia e statistica. On 18 April 1950 the society decided to expand its fields of interest also to economics and obtained its current name. In 1950 the society's journal was renamed accordingly to Italia
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