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https://en.wikipedia.org/wiki/Gallium%20phosphate
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Gallium phosphate (GaPO4 or gallium orthophosphate) is a colorless trigonal crystal with a hardness of 5.5 on the Mohs scale. GaPO4 is isotypic with quartz, possessing very similar properties, but the silicon atoms are alternately substituted with gallium and phosphorus, thereby doubling the piezoelectric effect. GaPO4 has many advantages over quartz for technical applications, like a higher electromechanical coupling coefficient in resonators, due to this doubling.
Contrary to quartz, GaPO4 is not found in nature. Therefore, a hydrothermal process must be used to synthesize the crystal.
Modifications
GaPO4 possesses, in contrast to quartz, no α-β phase transition, thus the low temperature structure (structure like α-quartz) of GaPO4 is stable up to 970°C, as are most of its other physical properties. Around 970°C another phase transition occurs which changes the low quartz structure into another structure similar with cristobalite.
Structure
The specific structure of GaPO4 shows the arrangement of tetrahedrons consisting of GaO4 and PO4 that are slightly tilted. Because of the helical arrangement of these tetrahedrons, two modifications of GaPO4 exist with different optical rotation (left and right).
Sources
GaPO4 does not occur in nature; thus it must be grown synthetically. Presently, only one company in Austria produces these crystals commercially.
History and technical importance
Pressure sensors based on quartz have to be cooled with water for applications at
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https://en.wikipedia.org/wiki/Gene%20orders
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Gene orders are the permutation of genome arrangement. A fair amount of research has been done trying to determine whether gene orders evolve according to a molecular clock (molecular clock hypothesis) or in jumps (punctuated equilibrium).
Some research on gene orders in animals' mitochondrial genomes reveal that the mutation rate of gene orders is not a constant in some degrees.
References
Genetics
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https://en.wikipedia.org/wiki/Studen%C3%A1%2C%20Slovakia
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Studená () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/S%C3%BAtor
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Sútor () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0imonovce
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Šimonovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0irkovce
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Širkovce () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/%C5%A0panie%20Pole
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Španie Pole () is a village and municipality in the Rimavská Sobota District of the Banská Bystrica Region of southern Slovakia.
References
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Rimavská Sobota District
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https://en.wikipedia.org/wiki/Specially%20Protected%20Areas%20of%20Mediterranean%20Importance
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Specially Protected Areas of Mediterranean Importance (SPAMI) are sites "of importance for conserving the components of biological diversity in the Mediterranean; contain ecosystems specific to the Mediterranean area or the habitats of endangered species; are of special interest at the scientific, aesthetic, cultural or educational levels".
Context
The Protocols are part of a wider international effort aimed at protecting the Mediterranean Sea, i.e. the MAP, a programme co-ordinated by UNEP the origins of which go back to the Barcelona Convention of 1976 for Protection against Pollution in the Mediterranean. Similar plans exist for other regional seas around the world. Treaties and protocols providing for the specific protection of certain sites in these regions have also been adopted.
The SPAMI List
The 1995 Protocol provides for the establishment of a List of SPAMI. SPAMI may be created both within areas of national jurisdiction and on the high seas. The decision to include an area in the SPAMI List is taken by consensus by the contracting parties during their periodic meetings. The protection and management measures applying in the SPAMI are those prescribed by the States proposing them but all parties are to comply with such measures. The Ligurian Sea Cetacean Sanctuary is the largest of the SPAMI sites.
The RAC-SPA
The Regional Activity Centre for Specially Protected Areas (RAC/SPA) was established by the Contracting Parties to the Barcelona Convention in order to
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https://en.wikipedia.org/wiki/Soy%20molasses
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Soy molasses is brown viscous syrup with a typical bittersweet flavor. A by-product of aqueous alcohol soy protein concentrate production, soy molasses is a concentrated, desolventized, aqueous alcohol extract of defatted soybean flakes.
The term "soy molasses" was coined by Daniel Chajuss, the founder of Hayes Ashdod Ltd., which first commercially produced and marketed soy molasses in the early 1960s. The name was intended to distinguish the product from “soybean whey” or “condensed soybean solubles”, the by-products available at the time from soy protein isolate and acid washed soy protein concentrate production.
Manufacture
The alcohols are removed from the liquid extract by evaporation and the distillation residue is an aqueous solution of the sugars and other soy solubles. This solution is concentrated to viscous honey-like consistency to yield soy molasses.
Composition
Typically, soy molasses contains 50% total soluble solids. These solids consist of carbohydrates (60%), proteins and other nitrogenous substances (10%), minerals (10%), fats and lipoids (20%). The major constituents of soy molasses are sugars that include oligosaccharides (stachyose and raffinose), disaccharides (sucrose) and minor amounts of monosaccharides (fructose and glucose). Minor constituents include saponins, protein, lipid, minerals (ash), isoflavones, and other organic materials.
Use
Soy molasses is used as a feed ingredient in mixed feeds as pelleting aid, added to soybean meal (e.g. by sp
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https://en.wikipedia.org/wiki/Crystal%20Jade
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Crystal Jade (Chinese: 翡翠餐饮集团), owned by Crystal Jade Culinary Concept Holdings, is a Singapore-based Chinese restaurant chain.
See also
List of Chinese restaurants
References
The Straits Times, "Clone Wars", 2006-10-15 The print article discussed competition between Crystal Jade and Imperial Treasure as well as reviewed both restaurants.
External links
Official website
Restaurant chains in Singapore
Chinese restaurants outside China
Restaurants established in 1991
1991 establishments in Singapore
Singaporean brands
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https://en.wikipedia.org/wiki/Thrifty%20gene%20hypothesis
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The thrifty gene hypothesis, or Gianfranco's hypothesis is an attempt by geneticist James V. Neel to explain why certain populations and subpopulations in the modern day are prone to diabetes mellitus type 2. He proposed the hypothesis in 1962 to resolve a fundamental problem: diabetes is clearly a very harmful medical condition, yet it is quite common, and it was already evident to Neel that it likely had a strong genetic basis. The problem is to understand how disease with a likely genetic component and with such negative effects may have been favoured by the process of natural selection. Neel suggested the resolution to this problem is that genes which predispose to diabetes (called 'thrifty genes') were historically advantageous, but they became detrimental in the modern world. In his words they were "rendered detrimental by 'progress'". Neel's primary interest was in diabetes, but the idea was soon expanded to encompass obesity as well. Thrifty genes are genes which enable individuals to efficiently collect and process food to deposit fat during periods of food abundance in order to provide for periods of food shortage (feast and famine).
According to the hypothesis, the 'thrifty' genotype would have been advantageous for hunter-gatherer populations, especially child-bearing women, because it would allow them to fatten more quickly during times of abundance. Fatter individuals carrying the thrifty genes would thus better survive times of food scarcity. However, in moder
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https://en.wikipedia.org/wiki/Monoacylglycerol%20lipase
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Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.
Function
Monoacylglycerol lipase catalyzes a reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids:
hydrolyses glycerol monoesters of long-chain fatty acids
It functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). It converts monoacylglycerols to the free fatty acid and glycerol. The contribution of MAGL to total brain 2-AG hydrolysis activity has been estimated to be ~85% (ABHD6 and ABHD12 are responsible for ~4% and ~9%, respectively, of the remainder), and this in vitro estimate has been confirmed in vivo by the selective MAGL inhibitor JZL184. Chronic inactivation of MAGL results in massive (>10-fold) elevations of brain 2-
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https://en.wikipedia.org/wiki/Haplogroup%20L0
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Haplogroup L0 is a human mitochondrial DNA (mtDNA) haplogroup.
Origin
L0 is one of two branches from the most recent common ancestor (MRCA) for the shared human maternal lineage. The haplogroup consists of five main branches (L0a, L0b, L0d, L0f, L0k). Four of them were originally classified into L1 subclades, L1a, L1d, L1f and L1k.
In 2014, ancient DNA analysis of a 2,330 year old male forager's skeleton in Southern Africa found that the specimen belonged to the L0d2c1c mtDNA subclade. This maternal haplogroup is today most closely associated with the Ju, a subgroup of the indigenous San people, which points to population continuity in the region. In 2016, a Late Iron Age desiccated mummy from the Tuli region in northern Botswana was also found to belong to haplogroup L0.
Distribution
L0 is found most commonly in Sub-Saharan Africa. It reaches its highest frequency in the Khoisan people at 73% on average. Some of the highest frequencies are: Namibia (!Xun) 79%, South Africa (Khwe/!Xun) 83%, and Botswana (!Kung) 100%.
Haplogroup L0d is found among Khoisan groups of Southern Africa closer to the Khoid side with (following L0k) being more Sanid but is largely restricted to the Khoisan as a whole. L0d is also commonly found in sections of the Coloured population of South Africa and frequencies range from 60% to 71%. This illustrates the massive maternal contribution of Khoisan people to sections of the Coloured population of South Africa.
Haplogroups L0k is the second mo
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https://en.wikipedia.org/wiki/Diacylglycerol%20lipase
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Diacylglycerol lipase, also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol:diacylglycerol + H2O ⇌ monoacylglycerol + free fatty acidDAGL has been studied in multiple domains of life, including bacteria, fungi, plants, insects, and mammals. By searching with BLAST for the previously sequenced microorganism DAGL, Bisogno et al discovered two distinct mammalian isoforms, designated DAGLα () and DAGLβ (). Most animal DAGL enzymes cluster into the DAGLα and DAGLβ isoforms.
Mammalian DAGL is a crucial enzyme in the biosynthesis of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in tissues. The endocannabinoid system has been identified to have considerable involvement in the regulation of homeostasis and disease. As a result, much effort has been made toward investigating the mechanisms of action and the therapeutic potential of the system's receptors, endogenous ligands, and enzymes like DAGLα and DAGLβ.
Structure
While both DAGLα and DAGLβ are extensively homologous (sharing 34% of their sequence), DAGLα (1042 amino acids) is much larger than DAGLβ (672 amino acids) due to the presence of a sizeable C-terminal tail in the former.
Both DAGLα and DAGLβ have a transmembrane domain at the N-terminal that starts with a conserved 19 amino acid cytoplasmic sequence followed by four transmembrane helices. These transmembrane helices are connected by three short loops, o
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https://en.wikipedia.org/wiki/All%20Over%20the%20World%20%28Electric%20Light%20Orchestra%20song%29
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"All Over the World" is a song by the Electric Light Orchestra (ELO). It is featured in the 1980 feature film Xanadu in a sequence with the film's stars Olivia Newton-John, Gene Kelly, and Michael Beck. The song also appears on the soundtrack album Xanadu, and was performed in the 2007 Broadway musical Xanadu.
Released after the single "Xanadu" (a collaboration with Olivia Newton-John), this was the third Top 20 ELO single released from the 1980 soundtrack, peaking at number 13 on the US Billboard Hot 100.
The sequence in the Xanadu film was filmed on location at the Beverly Hills Fiorucci store.
One section of the lyrics lists a number of famous cities; London, Hamburg, Paris, Rome, Rio de Janeiro, Hong Kong, Tokyo, Los Angeles, New York City, Amsterdam and Monte Carlo. The last place named in the list is Shard End, the suburb of Birmingham, England where Jeff Lynne was born.
Cash Box called it "souped up '50s and '60s pop at its best", and praised the hook. Billboard called it one of ELO's "catchier tunes". Record World said that "a spirited chorus, triumphant keyboards & multitudinous handclaps carry the joyous, uplifting message".
This song featured prominently in the trailer for the Simon Pegg science fiction comedy film Paul and also played at the end of the film before the credits.
Personnel
Credits adapted from the album Xanadu:
Jeff Lynne – lead vocals, backing vocals, electric guitars, acoustic guitars, synthesizers
Bev Bevan – drums, percussion, tympani
Ri
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https://en.wikipedia.org/wiki/RATS
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RATS may refer to:
RATS (software), Regression Analysis of Time Series, a statistical package
Robot Astronomy Talk Show, an animated educational series that's part of NASA's IRrelevant Astronomy vodcast
Regional Anti-Terrorist Structure, the Shanghai Cooperation Organisation's anti-terrorism branch
See also
Rat (disambiguation)
The Rat (disambiguation)
The Rats (disambiguation)
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https://en.wikipedia.org/wiki/United%20States%20Consumer%20Price%20Index
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The United States Consumer Price Index (CPI) is a set of various consumer price indices published monthly by the U.S. Bureau of Labor Statistics (BLS). The most commonly used are the CPI-U and the CPI-W, though many alternative versions exist. The CPI-U is the most popular measure of consumer inflation in the United States (though Social Security benefit payments are indexed to the CPI-W).
Methodology
Item coverage
The CPI measures the monthly price change of a basket of discretionary consumption goods whose price is borne by the consumer. There are eight major categories of items that are included in the CPI coverage; each includes both goods and services:
Food and beverages
Housing
Apparel
Transportation
Medical care
Recreation
Education and communication
Other goods and services
In line with this framework, the CPI excludes items such as life insurance, investment securities, financing costs, house prices (though the value of owned housing, distinct from a house price, is included in the CPI), as these are considered to be investment items, not consumption. Also excluded are income and property taxes, employer-provided benefits, and the portion of healthcare costs paid by the government or insurance plans, since these prices are not borne directly by consumers. However, sales and excise taxes, out-of-pocket healthcare costs, and health insurance premiums paid by the consumer (including Medicare Part B) are all included in the CPI, because consumers directly be
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https://en.wikipedia.org/wiki/MDIA
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MDIA may refer to:
mDia, or mammalian diaphanous, a Rho effector protein involved in cytoskeletal polymerisation (see DIAPH1)
Men's Division of Intercollegiate Associates, now called the Men's Collegiate Lacrosse Association
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https://en.wikipedia.org/wiki/Amel%20%28disambiguation%29
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Amel is a municipality and village in the German-speaking Community of Belgium.
Amel may also refer to:
Amel (name)
Amelogenin (AMELY and AMELX), sex determining DNA chromosomal markers
Amel (river), a Belgian river also known as Amblève
Amel (UAV), a drone
Amel Yachts
Amel Association International, a Lebanese non-profit non-governmental organization
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https://en.wikipedia.org/wiki/Neanderthal%20genome%20project
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The Neanderthal genome project is an effort of a group of scientists to sequence the Neanderthal genome, founded in July 2006.
It was initiated by 454 Life Sciences, a biotechnology company based in Branford, Connecticut in the United States and is coordinated by the Max Planck Institute for Evolutionary Anthropology in Germany. In May 2010 the project published their initial draft of the Neanderthal genome (Vi33.16, Vi33.25, Vi33.26) based on the analysis of four billion base pairs of Neanderthal DNA. The study determined that some mixture of genes occurred between Neanderthals and anatomically modern humans and presented evidence that elements of their genome remain in modern humans outside Africa.
In December 2013, a high coverage genome of a Neanderthal was reported for the first time. DNA was extracted from a toe fragment from a female Neanderthal researchers have dubbed the "Altai Neandertal". It was found in Denisova Cave in the Altai Mountains of Siberia and is estimated to be 50,000 years old.
Findings
The researchers recovered ancient DNA of Neanderthals by extracting the DNA from the femur bones of three 38,000 year-old female Neanderthal specimens from Vindija Cave, Croatia, and other bones found in Spain, Russia, and Germany. Only about half a gram of the bone samples (or 21 samples each 50–100 mg) was required for the sequencing, but the project faced many difficulties, including the contamination of the samples by the bacteria that had colonized the Neander
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https://en.wikipedia.org/wiki/Crystal%20Heights%2C%20Nova%20Scotia
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Crystal Heights is a neighborhood in the north end of the Dartmouth area in Nova Scotia's Halifax Regional Municipality.
Part of the larger neighbourhood of Albro Lake, Crystal Heights is a development comprising high-density apartment buildings. It is adjacent to Highfield Park, a similar development dating to the 1970s.
Communities in Halifax, Nova Scotia
Dartmouth, Nova Scotia
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https://en.wikipedia.org/wiki/Compact%20operator%20on%20Hilbert%20space
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In the mathematical discipline of functional analysis, the concept of a compact operator on Hilbert space is an extension of the concept of a matrix acting on a finite-dimensional vector space; in Hilbert space, compact operators are precisely the closure of finite-rank operators (representable by finite-dimensional matrices) in the topology induced by the operator norm. As such, results from matrix theory can sometimes be extended to compact operators using similar arguments. By contrast, the study of general operators on infinite-dimensional spaces often requires a genuinely different approach.
For example, the spectral theory of compact operators on Banach spaces takes a form that is very similar to the Jordan canonical form of matrices. In the context of Hilbert spaces, a square matrix is unitarily diagonalizable if and only if it is normal. A corresponding result holds for normal compact operators on Hilbert spaces. More generally, the compactness assumption can be dropped. As stated above, the techniques used to prove results, e.g., the spectral theorem, in the non-compact case are typically different, involving operator-valued measures on the spectrum.
Some results for compact operators on Hilbert space will be discussed, starting with general properties before considering subclasses of compact operators.
Definition
Let be a Hilbert space and be the set of bounded operators on . Then, an operator is said to be a compact operator if the image of each bounded set
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https://en.wikipedia.org/wiki/DNA%20adenine%20methylase
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DNA adenine methylase, (Dam) (also site-specific DNA-methyltransferase (adenine-specific), , modification methylase, restriction-modification system) is an enzyme that adds a methyl group to the adenine of the sequence 5'-GATC-3' in newly synthesized DNA. Immediately after DNA synthesis, the daughter strand remains unmethylated for a short time. It is an orphan methyltransferase that is not part of a restriction-modification system and regulates gene expression. This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
This is a large group of enzymes unique to prokaryotes and bacteriophages.
The E. coli DNA adenine methyltransferase enzyme (Dam), is widely used for the chromatin profiling technique DamID, in which the Dam is fused to a DNA-binding protein of interest and expressed as a transgene in a genetically tractable model organism to identify protein binding sites.
Role in mismatch repair of DNA
When DNA polymerase makes an error resulting in a mismatched base-pair or a small insertion or deletion during DNA synthesis, the cell will repair the DNA by a pathway called mismatch repair. However, the cell must be able to differentiate between the template strand and the newly synthesized strand. In some bacteria, DNA strands are methylated by Dam methylase, and therefore, immediately after replication, the DNA will be hemimethylated. A repair enzyme, MutS, binds to mismatches in
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https://en.wikipedia.org/wiki/Basic%20pitch%20count%20estimator
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In baseball statistics, the basic pitch count estimator is a statistic used to estimate the number of pitches thrown by a pitcher where there is no pitch count data available. The formula was first derived by Tom Tango. The formula is , where PA refers to the number of plate appearances against the pitcher, SO to strikeouts and BB to base on balls.
See also
Pitch count
Batters faced by pitcher
References
Pitching statistics
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https://en.wikipedia.org/wiki/Ran%20%28protein%29
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Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.
Ran is a small G protein that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein has also been implicated in the control of DNA synthesis and cell cycle progression, as mutations in Ran have been found to disrupt DNA synthesis.
Function
Ran cycle
Ran exists in the cell in two nucleotide-bound forms: GDP-bound and GTP-bound. RanGDP is converted into RanGTP through the action of RCC1, the nucleotide exchange factor for Ran. RCC1 is also known as RanGEF (Ran Guanine nucleotide Exchange Factor). Ran's intrinsic GTPase-activity is activated through interaction with Ran GTPase activating protein (RanGAP), facilitated by complex formation with Ran-binding protein (RanBP). GTPase-activation leads to the conversion of RanGTP to RanGDP, thus closing the Ran cycle.
Ran can diffuse freely within the cell, but because RCC1 and RanGAP are located in different places in the cell, the concentration of RanGTP and RanGDP differs locally as well, creating concentration gradients that act as signals for other cellular processes. RCC1 is bound to chromatin and therefore located inside the nucleus. RanGAP is cytoplasmic in yeast
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https://en.wikipedia.org/wiki/Rural%20Municipality%20of%20Piney
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The Rural Municipality of Piney is a rural municipality (RM) in southeastern Manitoba, Canada, along the border with Minnesota in the United States.
Geography
According to Statistics Canada, the municipality has a land area of 2,433.77 km2. It is bordered by the rural municipalities of Stuartburn, La Broquerie, and Reynolds, as well as the Buffalo Point 36 Indian reserve and an unorganized part of the province (Division No. 1, Unorganized, Manitoba).
The municipality borders Roseau County in the U.S. state of Minnesota. There are three international border crossings in Piney, the most of any Manitoba municipality: Pinecreek–Piney, Roseau–South Junction, and Warroad–Sprague Border Crossings.
A minority but large part of Sandilands Provincial Forest is located here, as is a small part of Northwest Angle Provincial Forest. Also, Cat Hills Provincial Forest and Wampum Provincial Forest are both entirely located here, but these two forests are relatively tiny in size.
Communities
Badger
Carrick
Menisino
Middlebro
Piney
St. Labre
Sandilands
South Junction
Sprague
Vassar
Wampum
Woodridge
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Piney had a population of 1,843 living in 804 of its 1,172 total private dwellings, a change of from its 2016 population of 1,726. With a land area of , it had a population density of in 2021.
In 2001, there were 690 housing units at an average density of 0.28/km2. 2.4% of the people in the municipal
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https://en.wikipedia.org/wiki/ZMap
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ZMap may refer to:
ZMap (software), a free and open-source network scanner
ZMap, an algorithm for storing cutter location values
ZMapp, an experimental treatment for Ebola virus disease
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https://en.wikipedia.org/wiki/Jimmy%20Carter%20%28footballer%29
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James William Charles Carter (born 9 November 1965) is an English former footballer. Playing as a winger, Carter featured for Crystal Palace, Queens Park Rangers, Millwall, Liverpool, Arsenal, Oxford United and Portsmouth throughout his career.
Early life
Carter was born on 9 November 1965, of mixed ancestry. His British surname came from a 17th-century ancestor who moved to India and married an Indian woman. His father Maurice originated from Kanpur in India, and was brought up in Lucknow. After being orphaned at 14, Maurice joined the merchant navy, came to England, and married Jimmy's English mother. When they divorced, Maurice brought up Jimmy and his brother 'as Indian kids'. Maurice (who died in January 2009) encouraged Jimmy to make it as a footballer, waking him early on frosty mornings to train.
Career
Carter began his professional career aged 14 at Crystal Palace, who released him when 19, and then had a brief spell with Queens Park Rangers, but failed to make a league appearance for either club.
Millwall bought Carter from QPR in 1987 for £15,000 and gave him his Football League debut in a 0–0 draw with Oldham at The Den in the Second Division. He quickly established himself in the first team and was an integral part of the team which gained promotion to the top flight in 1987–88, the first time ever in Millwall's 100-year history. In December of that season, Sheffield United defender Chris Wilder was sent off for a crude tackle on Carter.
Carter was part of
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https://en.wikipedia.org/wiki/RocketDock
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RocketDock is an application launcher developed by PolyVector and Skunkie of Punk Labs, working with artist Zachary Denton, for Windows that provides a dock similar to that of the Mac OS X Aqua GUI. It is freely available under a Creative Commons license and is distributed by Punk Labs (previously called Punk Software).
RocketDock is able to show live updates of minimized windows as in Mac OS X, and in Windows Vista it can show live thumbnail updates on the taskbar. It is compatible with MobyDock, ObjectDock, RK Launcher, and Y'z Dock skins, and is compatible with and borrows from Stardock ObjectDock's publicly published Docklet API.
The RocketDock gallery had a thriving community where users could upload and share skins, icons, docklets, wallpapers and other customization resources for the application. However, PunkLabs closed the RocketDock gallery on 6 August, 2018. Visiting the link now redirects to the official site of the developers of RocketDock, where a download for RocketDock is available.
See also
Dock (computing)
Objectdock
List of dock applications
References
Seth Rosenblatt, (5 December 2007), CNET editors' review, CNet
Preston Gralla, Editorial Review of RocketDock, PC World
External links
RocketDock website (now redirected to punklabs.com)
Punk Labs website
Rocketdock at Deviantart
Application launchers
Windows-only freeware
Portable software
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https://en.wikipedia.org/wiki/List%20of%20misnamed%20theorems
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This is a list of misnamed theorems in mathematics. It includes theorems (and lemmas, corollaries, conjectures, laws, and perhaps even the odd object) that are well known in mathematics, but which are not named for the originator. That is, these items on this list illustrate Stigler's law of eponymy (which is not, of course, due to Stephen Stigler, who credits Robert K Merton).
== Applied mathematics ==
Benford's law. This was first stated in 1881 by Simon Newcomb, and rediscovered in 1938 by Frank Benford. The first rigorous formulation and proof seems to be due to Ted Hill in 1988.; see also the contribution by Persi Diaconis.
Bertrand's ballot theorem. This result concerning the probability that the winner of an election was ahead at each step of ballot counting was first published by W. A. Whitworth in 1878, but named after Joseph Louis François Bertrand who rediscovered it in 1887. A common proof uses André's reflection method, though the proof by Désiré André did not use any reflections.
Algebra
Burnside's lemma. This was stated and proved without attribution in Burnside's 1897 textbook, but it had previously been discussed by Augustin Cauchy, in 1845, and by Georg Frobenius in 1887.
Cayley–Hamilton theorem. The theorem was first proved in the easy special case of 2×2 matrices by Cayley, and later for the case of 4×4 matrices by Hamilton. But it was only proved in general by Frobenius in 1878.
Hölder's inequality. This inequality was first established by Leonard Jam
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https://en.wikipedia.org/wiki/CYP27A1
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CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the mitochondria. It is most prominently involved in the biosynthesis of bile acids.
Function
CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3β-hydroxy-5-cholestenoic acid.
While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
Clinical significance
Mutations in CYP27A1 are associated with cerebrotendineous xanthomatosis, a rare lipid storage disease.
Inhibitors of CYP27A1 may be effective as adjuvants in the treatment of ER-positive breast cancer due to inhibition of the production of 27-hydroxycholesterol (which has estrogenic actions and stimulates the growth of ER-positive breast cancer cells). Some marketed drugs that have been identified as CYP27A1 inhibitors include anastrozole, fadrozole, bicalutamide, dexmedetomidine, r
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https://en.wikipedia.org/wiki/Erythropoietic%20porphyria
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Erythropoietic porphyria is a type of porphyria associated with erythropoietic cells. In erythropoietic porphyrias, the enzyme deficiency occurs in the red blood cells.
Types
There are three types:
Presentation
X-linked dominant erythropoietic protoporphyria is a relatively mild version of porphyria with the predominant symptom being extreme photosensitivity causing severe itching and burning sensation of the skin due to the buildup of protoporphyrin IX. One possible treatment was discovered when treating an individual with supplemental iron for a gastric ulcer. Levels of free protoporphyrin decreased significantly as there was iron available for the FECH to produce heme. Levels of zinc-protoporphyrin, however did not decrease.
Cause
X-linked sideroblastic anemia or "X-linked dominant erythropoietic protoporphyria", associated with ALAS2 (aminolevulinic acid synthase), has also been described. X-linked dominant erythropoietic protoporphyria (XDEPP) is caused by a gain of function mutation in the ALAS2 (5-aminolevulinate synthase) gene; that gene encodes the very first enzyme in the heme biosynthetic pathway. The mutation is caused by a frameshift mutation caused by one of two deletions in the ALAS2 exon 11, either c. 1706-1709 delAGTG or c. 1699-1700 delAT. This alters the 19th and 20th residues of the C-terminal domain thereby altering the secondary structure of the enzyme. The delAT mutation only occurred in one family studied whereas the delAGTG mutation occurred
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https://en.wikipedia.org/wiki/Diffusion%20%28acoustics%29
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Diffusion, in architectural acoustics, is the spreading of sound energy evenly in a given environment. A perfectly diffusive sound space is one in which the reverberation time is the same at any listening position.
Most interior spaces are non-diffusive; the reverberation time is considerably different around the room. At low frequencies, they suffer from prominent resonances called room modes.
Diffusor
Diffusors (or diffusers) are used to treat sound aberrations, such as echoes, in rooms. They are an excellent alternative or complement to sound absorption because they do not remove sound energy, but can be used to effectively reduce distinct echoes and reflections while still leaving a live sounding space. Compared to a reflective surface, which will cause most of the energy to be reflected off at an angle equal to the angle of incidence, a diffusor will cause the sound energy to be radiated in many directions, hence leading to a more diffusive acoustic space. It is also important that a diffusor spreads reflections in time as well as spatially. Diffusors can aid sound diffusion, but this is not why they are used in many cases; they are more often used to remove coloration and echoes.
Diffusors come in many shapes and materials. The birth of modern diffusors was marked by Manfred R. Schroeders' invention of number-theoretic diffusors in the 1970s.
Maximum length sequence diffusors
Maximum length sequence based diffusors are made of strips of material with two different
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https://en.wikipedia.org/wiki/Arylsulfatase%20B
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Arylsulfatase B (N-acetylgalactosamine-4-sulfatase, chondroitinsulfatase, chondroitinase, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, ) is an enzyme associated with mucopolysaccharidosis VI (Maroteaux–Lamy syndrome).
Arylsulfatase B is among a group of arylsulfatase enzymes present in the lysosomes of the liver, pancreas, and kidneys of animals. The purpose of the enzyme is to hydrolyze sulfates in the body. ARSB does this by breaking down glycosaminoglycans (GAGs), which are large sugar molecules in the body. ARSB targets two GAGs in particular: dermatan sulfate and chondroitin sulfate.
Over 130 mutations to ARSB have been found, each leading to a deficiency in the body. In most cases, the mutation occurs on a single nucleotide in the sequence. An arylsulfatase B deficiency can lead to an accumulation of GAGs in lysosomes, which in turn can lead to mucopolysaccharidosis VI.
Used as a pharmaceutical drug, the enzyme is known under the International Nonproprietary Name galsulfase and is sold under the brand name Naglazyme. Galsulfase was approved for medical use in the United States in May 2005 and in European Union in January 2006. Galsulfase is indicated for long-term enzyme-replacement therapy in people with a confirmed diagnosis of mucopolysaccharidosis VI (MPS VI; N-acetylgalactosamine-4-sulfatase deficiency; Maroteaux-Lamy syndrome).
Structure
The primary structure of Escherichia coli arylsulfatase B contains a primary sequenc
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https://en.wikipedia.org/wiki/Maroteaux%E2%80%93Lamy%20syndrome
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Maroteaux–Lamy syndrome, or Mucopolysaccharidosis Type VI (MPS-VI), is an inherited disease caused by a deficiency in the enzyme arylsulfatase B (ARSB). ASRB is responsible for the breakdown of large sugar molecules called glycosaminoglycans (GAGs, also known as mucopolysaccharides). In particular, ARSB breaks down dermatan sulfate and chondroitin sulfate. Because people with MPS-VI lack the ability to break down these GAGs, these chemicals build up in the lysosomes of cells. MPS-VI is therefore a type of lysosomal storage disease.
Signs and symptoms
Unlike other MPS diseases, children with Maroteaux–Lamy syndrome usually have normal intelligence. They share many of the physical symptoms found in Hurler syndrome. Maroteaux–Lamy syndrome has a variable spectrum of severe symptoms. Neurological complications include clouded corneas, deafness, thickening of the dura (the membrane that surrounds and protects the brain and spinal cord), and pain caused by compressed or traumatized nerves and nerve roots.
At birth, people with Maroteaux-Lamy syndrome typically do not display any signs or symptoms. Signs are revealed early in the affected child's life, with one of the first symptoms often being a significantly prolonged age of learning how to walk. Growth begins normally, but children usually stop growing by age 8. By age 10, children often develop a shortened trunk, crouched stance, and restricted joint movement. In more severe cases, children also develop a protruding abdomen a
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https://en.wikipedia.org/wiki/Aspartylglucosaminidase
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N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.
Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.
References
External links
Further reading
External links
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https://en.wikipedia.org/wiki/FC%20Swarovski%20Tirol
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FC Swarovski Tirol was an Austrian association football club from 1986 to 1992, based in Innsbruck, Tyrol, Austria.
History
It was created by crystal manufacturer Swarovski as a split-off of FC Wacker Innsbruck, whose Bundesliga license it adopted at the end of the 1985–86 season. With manager Ernst Happel it won the Austrian football championship of 1989 and 1990 as well as the Austrian Cup in 1989. It nevertheless was dissolved in 1992 and the license fell back to FC Wacker, only to change over again to the newly established FC Tirol Innsbruck one year later.
Honours
Austrian Championship (2): 1988–89, 1989–90
Austrian Championship Runners-up (1): 1990–91
Austrian Cup (1): 1988–89
Austrian Cup Runners-up (2): 1986–87, 1987–88
Austrian Supercup Runners-up (3): 1987, 1989, 1990
European Cup history
Q = Qualifying QF = Quarterfinal SF = Semifinal
Manager history
Felix Latzke (1 July 1985 – 30 June 1987)
Ernst Happel (1 July 1987 – 1 Dec 1991)
Horst Hrubesch (1 Jan 1992 – 31 May 1992)
External links
Association football clubs established in 1986
Association football clubs disestablished in 1986
Defunct football clubs in Austria
Sport in Innsbruck
1986 establishments in Austria
1992 disestablishments in Austria
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https://en.wikipedia.org/wiki/Emopamil%20binding%20protein
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Emopamil binding protein is a protein that in humans is encoded by the EBP gene, located on the X chromosome. The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil, resulting in its discovery and given name. EBP has a mass of 27.3 kDa and resembles a σ-receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein.
Clinical significance
Mutations in EBP cause Conradi–Hünermann syndrome and impairs cholesterol biosynthesis. Unborn males affected with EBP mutations are not expected to be liveborn, (with up to only 5% male births). Individuals, mostly female, that are liveborn with EBP mutations experience stunted growth, limb reduction and back problems. Later in life, the individual may develop cataracts along with coarse hair and hair loss.
Cloning
Isolation, replication and characterization of the EBP and EBP-like protein have been performed in yeast/E. Coli strains (which lack the EBP protein in nature) to study the high-affinity drug binding effects.
See also
Emopamil
Cholestenol Delta-isomerase
Sigma-1 receptor
Sigma-2 receptor
References
External links
GeneReviews/NCBI/NIH/UW entry on Chondrodysplasia Punctata 2, X-Linked, Conradi-Hünermann Syndrome, Happle Syndrome
Genetics
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https://en.wikipedia.org/wiki/Conradi%E2%80%93H%C3%BCnermann%20syndrome
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Conradi–Hünermann syndrome is a rare type of chondrodysplasia punctata. It is associated with the EBP gene and affects between one in 100,000 and one in 200,000 babies.
Signs and symptoms
Possible signs and symptoms may include
Genetics
Conradi–Hünermann syndrome is a form of chondrodysplasia punctata, a group of rare genetic disorders of skeletal development involving abnormal accumulations of calcium salts within the growing ends of long bones. Conradi–Hünermann syndrome is commonly associated with mild to moderate growth deficiency, disproportionate shortening of long bones, particularly those of the upper arms and the thigh bones, short stature, and/or curvature of the spine. In rare cases, intellectual disability may also be present. While evidence suggests that Conradi–Hünermann syndrome predominantly occurs in females and is usually inherited as an X-linked dominant trait, rare cases in which males were affected have also been reported.
The genetics of Conradi–Hünermann syndrome have perplexed medical geneticists, pediatricians and dermatologists for some time, but a number of perplexing features of the genetics of the syndrome have now been resolved, including the fact that the disease is caused by mutations in a gene, and these mutations are simple substitutions, deletions or insertions and are therefore not "unstable". Scientists are still trying to understand exactly where the mutation occurs so that they can correct it.
Diagnosis
An important test to confirm a
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https://en.wikipedia.org/wiki/Wasserstein%20metric
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In mathematics, the Wasserstein distance or Kantorovich–Rubinstein metric is a distance function defined between probability distributions on a given metric space . It is named after Leonid Vaseršteĭn.
Intuitively, if each distribution is viewed as a unit amount of earth (soil) piled on , the metric is the minimum "cost" of turning one pile into the other, which is assumed to be the amount of earth that needs to be moved times the mean distance it has to be moved. This problem was first formalised by Gaspard Monge in 1781. Because of this analogy, the metric is known in computer science as the earth mover's distance.
The name "Wasserstein distance" was coined by R. L. Dobrushin in 1970, after learning of it in the work of Leonid Vaseršteĭn on Markov processes describing large systems of automata (Russian, 1969). However the metric was first defined by Leonid Kantorovich in The Mathematical Method of Production Planning and Organization (Russian original 1939) in the context of optimal transport planning of goods and materials. Some scholars thus encourage use of the terms "Kantorovich metric" and "Kantorovich distance". Most English-language publications use the German spelling "Wasserstein" (attributed to the name "Vaseršteĭn" () being of German origin).
Definition
Let be a metric space that is a Radon space. For , the Wasserstein -distance between two probability measures and on with finite -moments is
where is the set of all couplings of and ; is defined to b
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https://en.wikipedia.org/wiki/Claire%20M.%20Fraser
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Claire M. Fraser (born 1955) is an American genome scientist and microbiologist who has worked in microbial genomics and genome medicine. Her research has contributed to the understanding of the diversity and evolution of microbial life. Fraser is the director of the Institute for Genome Sciences at the University of Maryland School of Medicine in Baltimore, MD, where she holds the Dean's Endowed Professorship in the School of Medicine. She has joint faculty appointments at the University of Maryland School of Medicine in the Departments of Medicine and Microbiology/Immunology. In 2019, she began serving a one-year term as President-Elect for the American Association for the Advancement of Science (AAAS), which will be followed by a one-year term as AAAS president starting in February 2020 and a one-year term as chair of the Board of Directors in February 2021.
Early life
Fraser was raised by a high school principal and an elementary school teacher in Saugus, MA a suburb of Boston, MA. She performed well at school and was always interested in learning. She became interested in science after being taught biology in high school. At Rensselaer Polytechnic Institute (RPI), during her senior year, she performed independent research in a research lab.
Education
Fraser received her B.S. degree in Biology from Rensselaer Polytechnic Institute in 1977 and her Ph.D. degree in Pharmacology at the State University of New York at Buffalo in 1981 with a thesis entitled "Autoantibodies a
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https://en.wikipedia.org/wiki/List%20of%20diseases%20spread%20by%20invertebrates
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Invertebrates are very common vectors of disease. A vector is an organism which spreads disease from one host to another. Invertebrates spread bacterial, viral and protozoan pathogens by two main mechanisms. Either via their bite, as in the case of malaria spread by mosquitoes, or via their faeces, as in the case of Chagas' Disease spread by Triatoma bugs or epidemic typhus spread by human body lice.
Many invertebrates are responsible for transmitting diseases. Mosquitoes are perhaps the best known invertebrate vector and transmit a wide range of tropical diseases including malaria, dengue fever and yellow fever. Another large group of vectors are flies. Sandfly species transmit the disease leishmaniasis, by acting as vectors for protozoan Leishmania species, and tsetse flies transmit protozoan trypansomes (Trypanosoma brucei gambiense and Trypansoma brucei rhodesiense) which cause African Trypanosomiasis (sleeping sickness). Ticks and lice form another large group of invertebrate vectors. The bacterium Borrelia burgdorferi, which causes Lyme Disease, is transmitted by ticks and members of the bacterial genus Rickettsia are transmitted by lice. For example, the human body louse transmits the bacterium Rickettsia prowazekii which causes epidemic typhus.
Although invertebrate-transmitted diseases pose a particular threat on the continents of Africa, Asia and South America, there is one way of controlling invertebrate-borne diseases, which is by controlling the invertebrate ve
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https://en.wikipedia.org/wiki/Schramm%E2%80%93Loewner%20evolution
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In probability theory, the Schramm–Loewner evolution with parameter κ, also known as stochastic Loewner evolution (SLEκ), is a family of random planar curves that have been proven to be the scaling limit of a variety of two-dimensional lattice models in statistical mechanics. Given a parameter κ and a domain in the complex plane U, it gives a family of random curves in U, with κ controlling how much the curve turns. There are two main variants of SLE, chordal SLE which gives a family of random curves from two fixed boundary points, and radial SLE, which gives a family of random curves from a fixed boundary point to a fixed interior point. These curves are defined to satisfy conformal invariance and a domain Markov property.
It was discovered by as a conjectured scaling limit of the planar uniform spanning tree (UST) and the planar loop-erased random walk (LERW) probabilistic processes, and developed by him together with Greg Lawler and Wendelin Werner in a series of joint papers.
Besides UST and LERW, the Schramm–Loewner evolution is conjectured or proven to describe the scaling limit of various stochastic processes in the plane, such as critical percolation, the critical Ising model, the double-dimer model, self-avoiding walks, and other critical statistical mechanics models that exhibit conformal invariance. The SLE curves are the scaling limits of interfaces and other non-self-intersecting random curves in these models. The main idea is that the conformal invariance and
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https://en.wikipedia.org/wiki/Albatros%20W.4
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The Albatros W.4 was a German floatplane derivative of the Albatros D.I fighter with new wing and tail surfaces of greater span than the D.I. One hundred eighteen examples (including three prototypes) were built between June 1916 and December 1917. The aircraft operated in the North Sea and Baltic theatres and later served as training aircraft.
The W.4 was powered by the same 120 kW (160 hp) Mercedes D.III engine fitted to the D.I and based on the same fuselage. The first production series W.4s were armed with one lMG08 7.92 mm (.312 in) machine gun. Later aircraft carried two guns.
Operators
Luftstreitkräfte - 118 aircraft
KuKLFT - 8 aircraft delivered in July 1918
Specifications (W.4)
References
Bibliography
Green, W. & Swanborough, G. (1994). The Complete Book of Fighters. London: Salamander Books.
luftfahrt-archiv.de
Grosz, Peter M. (1995). Albatros W4. Windsock Mini Datafile No. 1. Berkhamsted: Albatros Productions. .
Biplanes
Single-engined tractor aircraft
1910s German fighter aircraft
Floatplanes
W.4
Aircraft first flown in 1916
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https://en.wikipedia.org/wiki/Kv1.1
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Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the KCNA1 gene. Isaacs syndrome is a result of an autoimmune reaction against the Kv1.1 ion channel.
Genomics
The gene is located on the Watson (plus) strand of the short arm of chromosome 12 (12p13.32). The gene itself is 8,348 bases in length and encodes a protein of 495 amino acids (predicted molecular weight 56.466 kiloDaltons).
Alternative names
The recommended name for this protein is potassium voltage-gated channel subfamily A member 1 but a number of alternatives have been used in the literature including HuK1 (human K+ channel I), RBK1 (rubidium potassium channel 1), MBK (mouse brain K+ channel), voltage gated potassium channel HBK1, voltage gated potassium channel subunit Kv1.1, voltage-gated K+ channel HuKI and AEMK (associated with myokymia with periodic ataxia).
Structure
The protein is believed to have six domains (S1-S6) with the loop between S5 and S6 forming the channel pore. This region also has a conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the protein associates with β subunits. These subunits regulate channel inactivation as well as its expression. The C-terminus is associated with a PDZ domain protein involved in channel targeting.
Function
The protein functions as a potassium selective channel through which the potassium ion may pass in con
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https://en.wikipedia.org/wiki/Albatros%20Dr.I
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The Albatros Dr. I was a German fighter triplane derivative of the D.V fitted with three pairs of wings instead of two. Identical in most other respects to the D.V, in the summer of 1917 it was flown side by side with the existing biplane in comparison trials. There was no discernible performance advantage and development was halted at the prototype stage.
Specifications
Notes
References
Gray, P. and Thetford, O. German Aircraft of the First World War. London: Putnam, 1962
Green, W. & Swanborough, G. The Complete Book of Fighters. London: Salamander Books, 1994
Single-engined tractor aircraft
1910s German fighter aircraft
Military aircraft of World War I
Dr.I
Triplanes
Aircraft first flown in 1917
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https://en.wikipedia.org/wiki/Pravica
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Pravica () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Vinica%2C%20Ve%C4%BEk%C3%BD%20Krt%C3%AD%C5%A1%20District
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Vinica () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.vinica.sk
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Vieska%2C%20Ve%C4%BEk%C3%BD%20Krt%C3%AD%C5%A1%20District
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Vieska () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Crystallography%20and%20NMR%20system
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CNS or Crystallography and NMR system, is a software library for computational structural biology. It is an offshoot of X-PLOR and uses much of the same syntax. It is used in the fields of X-ray crystallography and NMR spectroscopy of biological macromolecules.
References
External links
The program's webpage and reference manual
Science software
Computer libraries
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https://en.wikipedia.org/wiki/Kawai%20XD-5
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The Kawai XD-5 is a percussion synthesizer based on the Kawai K4 sample playback (but uses 16-bit 44.1 kHz sample rate as opposed to 32 kHz ) with filter and AM amplifier modulation synthesis architecture. It is essentially a Kawai K4r with percussion waveforms, plus faster envelopes, gate mode and amplifier to better suit percussion sounds. The XD-5 also features include 32 digital oscillators each capable of using one of 256 available 16-bit waveforms, a digital filter with self resonance and 8 individual outputs.
Expandability
The XD-5 uses expansion cards to allow an increased number of tones to be stored externally.. One card can hold 64 Patches, 16 kit Patches and 16 output patches.
Sounds
Kick, snare, rim, tom, hi hat, cymbals and other assorted percussion sounds as well as 41 Digital Cyclic waveforms.
Notable users
THD
Tim Conrardy
Klangwelt
Richie Hawtin
References
External links
Text from the original XD-5 sales brochure archived on Audio Playground
Kawai synthesizers
Drum machines
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https://en.wikipedia.org/wiki/Random%20effects%20model
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In statistics, a random effects model, also called a variance components model, is a statistical model where the model parameters are random variables. It is a kind of hierarchical linear model, which assumes that the data being analysed are drawn from a hierarchy of different populations whose differences relate to that hierarchy. A random effects model is a special case of a mixed model.
Contrast this to the biostatistics definitions, as biostatisticians use "fixed" and "random" effects to respectively refer to the population-average and subject-specific effects (and where the latter are generally assumed to be unknown, latent variables).
Qualitative description
Random effect models assist in controlling for unobserved heterogeneity when the heterogeneity is constant over time and not correlated with independent variables. This constant can be removed from longitudinal data through differencing, since taking a first difference will remove any time invariant components of the model.
Two common assumptions can be made about the individual specific effect: the random effects assumption and the fixed effects assumption. The random effects assumption is that the individual unobserved heterogeneity is uncorrelated with the independent variables. The fixed effect assumption is that the individual specific effect is correlated with the independent variables.
If the random effects assumption holds, the random effects estimator is more efficient than the fixed effects model.
Sim
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https://en.wikipedia.org/wiki/Iduronate-2-sulfatase
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Iduronate 2-sulfatase (EC 3.1.6.13; systematic name L-iduronate-2-sulfate 2-sulfohydrolase) is a sulfatase enzyme associated with Hunter syndrome. It catalyses hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
Function
Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. At least 174 disease-causing mutations in this gene have been discovered. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.
See also
Idursulfase
References
Further reading
External links
GeneReviews/NIH/NCBI/UW entry on Mucopolysaccharidosis Type II
EC 3.1.6
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https://en.wikipedia.org/wiki/N-acetylgalactosamine-4-sulfatase
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N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase. It catalyses the following reaction:
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
It also acts on N-acetylglucosamine 4-sulfate.
See also
Arylsulfatase B
References
External links
EC 3.1.6
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https://en.wikipedia.org/wiki/Picamar
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Picamar is a colorless, hydrocarbon oil extracted from the creosote of beechwood tar with a peculiar odor and bitter taste. It consists of derivatives of pyrogallol. It was discovered by German chemist Carl Reichenbach in the 1830s. Picamar can be used to lubricate machinery.
Chemical and physical properties
The exact composition of picamar is unknown. According to Pastrovich, picamar is a monomethyl ether of propyl-pyrogallol (). However, Gustav Niederist, who obtained an original sample of the oil as prepared by von Reichenbach himself, assigned it a formula of . Picamar is colorless with a peculiar, peppermint-like odor and bitter taste. It is soluble in alcohol and sparingly soluble in water. It has a melting point of . Picamar reduces the red oxide of mercury to its metallic state. It reacts with nitric acid to become a reddish-brown, greasy substance and can also dissolve camphor, resin, and benzoic acids.
History
The name "picamar" is derived from the Latin phrase in pice amarum (meaning "bitter principle of tar"). It was discovered by German chemist Carl Reichenbach in the 1830s as one of the six principles of beechwood tar, along with other substances as capnomor and eupione that were "met with less notice".
Applications
Picamar is used for greasing machinery and preventing them from rusting.
References
Hydrocarbons
Phenols
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https://en.wikipedia.org/wiki/Glyceronephosphate%20O-acyltransferase
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Glyceronephosphate O-acyltransferase is an enzyme associated with Rhizomelic chondrodysplasia punctata type 2.
GNPAT is located on chromosome 1 on the plus strand. The gene C1orf131 is located directly upstream of it, and the closest downstream gene is EXOC8.
References
External links
EC 2.3.1
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https://en.wikipedia.org/wiki/International%20Classification%20of%20Sleep%20Disorders
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The International Classification of Sleep Disorders (ICSD) is "a primary diagnostic, epidemiological and coding resource for clinicians and researchers in the field of sleep and sleep medicine". The ICSD was produced by the American Academy of Sleep Medicine (AASM) in association with the European Sleep Research Society, the Japanese Society of Sleep Research, and the Latin American Sleep Society. The classification was developed as a revision and update of the Diagnostic Classification of Sleep and Arousal Disorders (DCSAD) that was produced by both the Association of Sleep Disorders Centers (ASDC) and the Association for the Psychophysiological Study of Sleep and was published in the journal Sleep in 1979. A second edition, called ICSD-2, was published by the AASM in 2005. The third edition, ICSD-3, was released by the AASM in 2014. A text revision of the third edition (ICSD-3-TR) was published in 2023 by the AASM.
Milestones of sleep disorder classifications
Introduction
In 1979, the first Diagnostic Classification of Sleep and Arousal Disorders (DCSAD) was developed by the Association of Sleep Disorders Centers (ASDC) and the Association for the Psychophysiological Study of Sleep. Disorders were divided into four main categories.
Disorders of initiating and maintaining sleep (DIMS) – Insomnias
Disorders of Excessive somnolence (DOES) – Hypersomnias
Disorders of the Sleep-Wake Schedule – Circadian Disorders
Dysfunctions Associated with Sleep, Sleep Stages, or Par
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https://en.wikipedia.org/wiki/Mehdi%20Hasheminasab
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Seyyed Mehdi Hasheminasab (; born January 27, 1974) is a retired Iranian footballer.
Club career
He served his golden days in Persepolis and Esteghlal.
Club career statistics
International career
After a number of very good seasons with Persepolis, Hasheminasab was called up to the national team, earning his first cap versus Kuwait on February 15, 1999. He was also a member of the national team during the World Cup 2002 qualification campaign. Some consider him and a number of other players to be responsible for the poor atmosphere in the national team camp, and its eventual failure to qualify. In his career he achieved 28 caps and 2 goals.
References
External links
Mehdi Hasheminasab at PersianLeague.com
Mehdi Hasheminasab at TeamMelli.com
Quds Daily
Tebyan
1973 births
Living people
Footballers from Abadan, Iran
Iranian men's footballers
Iran men's international footballers
Iranian expatriate men's footballers
Expatriate men's footballers in Turkmenistan
FK Köpetdag Aşgabat players
Esteghlal F.C. players
Persepolis F.C. players
Siah Jamegan F.C. players
PAS Tehran F.C. players
Sanat Naft Abadan F.C. players
Payam Khorasan F.C. players
F.C. Aboomoslem players
Azadegan League players
2000 AFC Asian Cup players
Men's association football defenders
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https://en.wikipedia.org/wiki/Batting%20average%20on%20balls%20in%20play
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In baseball statistics, batting average on balls in play (abbreviated BABIP) is a measurement of how often batted balls result in hits, excluding home runs. It can be expressed as, "when you hit the ball and it’s not a home run, what’s your batting average?" The statistic is typically used to evaluate individual batters and individual pitchers.
Calculation
BABIP is computed per the following equation, where H is hits, HR is home runs, AB is at bats, K is strikeouts, and SF is sacrifice flies.
Effect
As compared to batting average, which is simply hits divided by at bats, BABIP excludes home runs and strikeouts from consideration while treating sacrifice flies as hitless at bats.
In Major League Baseball (MLB), .300 is considered an average BABIP. Various factors can impact BABIP, such as a player's home ballpark; for batters, being speedy enough to reach base on infield hits; or, for pitchers, the quality of their team's defense.
Usage
BABIP is commonly used as a red flag in sabermetric analysis, as a consistently high or low BABIP is hard to maintain—much more so for pitchers than hitters. Therefore, BABIP can be used to spot outlying seasons by pitchers. As with other statistical measures, those pitchers whose BABIPs are extremely high (bad) can often be expected to improve in the following season, and those pitchers whose BABIPs are extremely low (good) can often be expected to worsen in the following season.
While a pitcher's BABIP may vary from season to season, th
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https://en.wikipedia.org/wiki/Catcher%27s%20ERA
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Catcher's ERA (CERA) in baseball statistics is the earned run average of the pitchers pitching when the catcher in question is catching. Its primary purpose is to measure a catcher's game-calling, rather than his effect on the opposing team's running game. Craig Wright first described the concept of CERA in his 1989 book The Diamond Appraised. With it, Wright developed a method of determining a catcher's effect on a team's pitching staff by comparing pitchers' performance when playing with different catchers.
Baseball Prospectus writer Keith Woolner has written that "catcher game-calling isn't a statistically significant skill" after doing statistical analysis of catcher performance. Sabermetrician Bill James also performed research into CERA, finding that while it is possible that catchers may have a significant effect on a pitching staff, there is too much yearly variation in CERA for it to be a reliable indicator of ability. James used simulations of catchers with assigned defensive values to directly compare CERAs, which influenced Woolner to perform similar simulations but instead using weighted events to calculate pitchers' runs per plate appearance. Through this, Woolner concluded that even if catchers do have an effect on pitchers' abilities to prevent runs, it is undetectable and thus has no practical usage. He also stated that "the hypothesis most consistent with the available facts appears to be that catchers do not have a significant effect on pitcher perfo
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https://en.wikipedia.org/wiki/Reservoir%20simulation
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Reservoir simulation is an area of reservoir engineering in which computer models are used to predict the flow of fluids (typically, oil, water, and gas) through porous media.
The creation of models of oil fields and the implementation of calculations of field development on their basis is one of the main areas of activity of engineers and oil researchers. On the basis of geological and physical information about the properties of an oil, gas or gas condensate field, consideration of the capabilities of the systems and technologies for its development create quantitative ideas about the development of the field as a whole. A system of interrelated quantitative ideas about the development of a field is a model of its development, which consists of a reservoir model and a model of a field development process. Layer models and processes for extracting oil and gas from them are always clothed in a mathematical form, i.e. characterized by certain mathematical relationships. The main task of the engineer engaged in the calculation of the development of an oil field is to draw up a calculation model based on individual concepts derived from a geological-geophysical study of the field, as well as hydrodynamic studies of wells. Generally speaking, any combination of reservoir models and development process can be used in an oil field development model, as long as this combination most accurately reflects reservoir properties and processes. At the same time, the choice of a particular
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https://en.wikipedia.org/wiki/Sri%20Lanka%20montane%20rain%20forests
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The Sri Lanka montane rain forests is an ecoregion found above 1,000 m in the central highlands of Sri Lanka. Owing to their rich biodiversity, this region is considered to be a super-hotspot within endemic hotspots of global importance. These forests are cooler than lowland forests and therefore they have ideal conditions for growth of cloud forests. These forests classifications tropical sub montane forest, tropical sub-montane and tropical upper montane. Half of Sri Lanka's endemic flowering plants and 51 percent of the endemic vertebrates are restricted to these forests. More than 34 percent of Sri Lanka's endemic trees, shrubs, and herbs can only be found in this ecoregion. Twisted, stunted trees are a common sight in these forests, together with many varieties of orchids, mosses and ferns. The trees of montane rain forests grow to a height 10–15 meters, shorter than the lowland rain forest trees. These high altitude forests are the catchment area for most of Sri Lanka's major rivers.
Forest cover
Sri Lanka's montane forests are located above 1,220 m. The montane rain forests cover 3,099.5 ha in total, or 0.05 percent of Sri Lanka's total area. These forests are found in the mountain tops, such as Pidurutalagala, Kikilimana, Meepilimana, Agrabopaththalawa, Adam's Peak and Hakgala. In lower elevations, at altitudes ranging 1,000–1,500 m, submontane forests occur; those forests account for 1.04 percent of the nation's area, totalling 65,793.3 ha.
Geological history
Sri L
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https://en.wikipedia.org/wiki/Malvidin
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Malvidin is an O-methylated anthocyanidin, the 3',5'-methoxy derivative of delphinidin. As a primary plant pigment, its glycosides are highly abundant in nature.
Natural occurrences
Malvidin is responsible for the blue color found in petals of the Primula plants of the polyanthus group. Blue flowers of the blue pimpernel (Anagallis monelli) have also a higher concentration of malvidin.
It is responsible primarily for the color of red wine, Vitis vinifera being one of its sources. It is also present in other berries, such as blueberries (Vaccinium corymbosum) or the saskatoon berries (Amelanchier alnifolia).
Chemistry
Slightly acidic and neutral solutions of malvidin are characteristically of a red color, while basic solutions of malvidin yield a blue color.
The breakdown of malvidin releases syringic acid.
Use as a marker in archaeology
The breakdown of malvidin releases syringic acid as revealed in the examination of jars containing shedeh, a drink of Ancient Egypt. Malvidin is also present in the site of the Areni-1 winery, a 6,100-year-old winery discovered in 2007 in the Areni-1 cave complex in the village of Areni in the Vayots Dzor province of Armenia.
Glycosides
Malvin is a malvidin diglucoside.
Oenin is the malvidin-3-glucoside.
Primulin is the 3-O-galactoside of malvidin.
Malvidin 3-rutinoside is a pigment responsible for bract color in Curcuma alismatifolia (the Siam tulip). Acylated malvidin 3-rutinosides are responsible for the violet color of Petuni
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https://en.wikipedia.org/wiki/Transistor%20Blast%3A%20The%20Best%20of%20the%20BBC%20Sessions
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Transistor Blast: The Best of the BBC Sessions is a 4-disc boxed set by the English rock band XTC, released by Cooking Vinyl in November 1998, just three months prior to the studio album Apple Venus Volume 1.
Tracks on the first two discs are culled from various BBC radio sessions the group performed on over the years, notably for John Peel and David Jensen. Discs three and four are live recordings, the latter of which was previously released as BBC Radio 1 Live in Concert and is now titled Live in Concert 1980 on streaming services such as Spotify and Apple Music.
"Opening Speech" from the first disc is Andy Partridge imitating John Peel.
Track listing
UK CD: COOKCD152
All songs written by Andy Partridge, except where noted.
Disc one
Studio sessions
"Opening Speech" – 0:49 [John Peel Show: Recorded 8 October 1979; Aired 15 October 1979]
"Life Begins at the Hop" (Colin Moulding) – 4:19 [David "Kid" Jensen Show: Recorded 21 May 1979; Aired 31 May 1979]
"Scarecrow People" – 4:13 [Richard Skinner Show: Recorded 16 March 1989; Aired 5 April 1989]
"Seagulls Screaming Kiss Her, Kiss Her" – 4:21 [Bruno Brookes Show: Recorded 11 October 1984; Aired 20 November 1984]
"Ten Feet Tall" (Moulding) – 2:53 [John Peel Show: Recorded 8 October 1979; Aired 15 October 1979]
"Garden of Earthly Delights" – 5:33 [Andy Kershaw Show: Recorded 16 March 1989; Aired 11 June 1989]
"Runaways" (Moulding) – 4:41 [David "Kid" Jensen Show: Recorded 14 January 1982; Aired 25 January 1982]
"When You're Ne
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https://en.wikipedia.org/wiki/Such%C3%A9%20Brezovo
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Suché Brezovo () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Fluocinolone%20acetonide
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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine with any confidence whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis. A fluocinolone acetonide intravitreal implant with the brand name Iluvien is sold by biopharmaceutical company Alimera Sciences to treat diabetic macular edema (DME).
It was approved for medical use in 1961.
Classification
Fluocinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.
See also
Topical steroid
Fluocinonide
Ciprocinonide
Glucocorticoid
References
Ext
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https://en.wikipedia.org/wiki/Meprednisone
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Meprednisone is a glucocorticoid. It is a methylated derivative of prednisone.
See also
Glucocorticoid
Corticosteroid
References
Diols
Glucocorticoids
Pregnanes
Triketones
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https://en.wikipedia.org/wiki/Slovensk%C3%A9%20%C4%8Earmoty
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Slovenské Ďarmoty () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
References
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Mu%C4%BEa
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Muľa () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
https://web.archive.org/web/20071217080336/http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/P%C3%B4tor
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Pôtor () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Pr%C3%ADbelce
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Príbelce () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Stredn%C3%A9%20Plachtince
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Stredné Plachtince () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Slovensk%C3%A9%20K%C4%BEa%C4%8Dany
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Slovenské Kľačany () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Se%C4%8Dianky
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Sečianky () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Such%C3%A1%C5%88
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Sucháň () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
It is also the best name ever!
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/NS1
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NS1, NS 1, NS-1, NS.1, or variation, may refer to:
Non-structural protein 1
NS1 influenza protein
NS1 dengue protein, used for NS1 antigen test
Human bocavirus NS1
Carnivore bocaparvovirus 1 NS1
Japanese encephalitis virus NS1
Minute virus of mice NS1
West Nile virus NS1
Yellow fever virus NS1
Places
Jurong East MRT station (station code: NS1), Jurong East, Singapore
Kawanishi-Noseguchi Station (station code: NS01), Kawanishi, Hyōgo Prefecture, Japan
Ōmiya Station (Saitama) (station code: NS01), Ōmiya-ku, Saitama, Japan
Annapolis (provincial electoral district), constituency N.S. 01; Nova Scotia, Canada
Aerospace
U.S.S. NS-1, a U.S. Navy airship; see British blimps operated by the USN
RAF N.S. 1, a British NS class airship
Spartan NS-1, U.S. military trainer biplane
Stearman NS-1, U.S. military trainer biplane
New Shepard 1, a Blue Origin reusable space launch vehicle booster rocket (booster #1)
Blue Origin NS-1, a 2015 April 29 Blue Origin suborbital spaceflight mission for the New Shepard
Other uses
Novelty seeking level 1, exploratory excitability
ns (simulator), version ns-1, computer network simulation software
Netscape Navigator 1.0/1.1; a webbrowser
See also
NSI (disambiguation)
NSL (disambiguation)
NS (disambiguation)
1 (disambiguation)
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https://en.wikipedia.org/wiki/Ulobetasol
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Ulobetasol (INN) or halobetasol (USAN) is a corticosteroid used to treat psoriasis. It is a class I corticosteroid under the US classification and a group III corticosteroid under international classification, the most potent group of such drugs.
Ulobetasol propionate is usually supplied as a 0.05% topical cream. Ulobetasol is the strongest topical steroid available. It is also sold with tazarotene with 0.01% halobetasol and 0.045% tazarotene as a lotion branded as Duobrii (Bausch Health).
It is available as a generic medication.
References
External links
Glucocorticoids
Organofluorides
Organochlorides
Alcohols
Ketones
Halohydrins
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https://en.wikipedia.org/wiki/Biodiversity%20action%20plan
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A biodiversity action plan (BAP) is an internationally recognized program addressing threatened species and habitats and is designed to protect and restore biological systems. The original impetus for these plans derives from the 1992 Convention on Biological Diversity (CBD). As of 2009, 191 countries have ratified the CBD, but only a fraction of these have developed substantive BAP documents.
The principal elements of a BAP typically include: (a) preparing inventories of biological information for selected species or habitats; (b) assessing the conservation status of species within specified ecosystems; (c) creation of targets for conservation and restoration; and (d) establishing budgets, timelines and institutional partnerships for implementing the BAP.
Species plans
A fundamental method of engagement to a BAP is thorough documentation regarding individual species, with emphasis upon the population distribution and conservation status. This task, while fundamental, is highly daunting, since only an estimated ten percent of the world’s species are believed to have been characterized as of 2006, most of these unknowns being fungi, invertebrate animals, micro-organisms and plants. For many bird, mammal and reptile species, information is often available in published literature; however, for fungi, invertebrate animals, micro-organisms and many plants, such information may require considerable local data collection. It is also useful to compile time trends of population est
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https://en.wikipedia.org/wiki/Halcinonide
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Halcinonide is a high potency corticosteroid, in group II (second most potent group) under US classification. It is used topically (in a 0.05% cream provided as Halog) in the treatment of certain skin conditions.
References
Acetonides
Secondary alcohols
Chloroarenes
Corticosteroid cyclic ketals
Corticosteroids
Diketones
Fluoroarenes
Glucocorticoids
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https://en.wikipedia.org/wiki/Magnetic%20developer
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Magnetic developer is a fluid which makes the magnetic information written on magnetic tape or the magnetic stripe of a credit card or ATM card visible to the naked eye.
Magnetic developer can be found in liquid or aerosol form. When applied to a magnetic stripe, suspended metal particles will be attracted to the magnetically charged regions of the stripe as the liquid evaporates. The particles can be made of carbonyl iron.
Magnetic developer can be used to troubleshoot problems with magnetic stripes and the equipment that encodes and reads them. By making the encoding visible, one can see how encoding head alignment affects the position of the data tracks, and observe any possible magnetic damage that has occurred on the magnetic stripe.
See also
Magnasee
References
Magnetic devices
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https://en.wikipedia.org/wiki/Se%C4%BEany
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Seľany () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/Senn%C3%A9%2C%20Ve%C4%BEk%C3%BD%20Krt%C3%AD%C5%A1%20District
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Senné () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/%C5%A0ir%C3%A1kov
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Širákov () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
Statistics
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/%C5%A0u%C4%BEa
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Šuľa () is a village and municipality in the Veľký Krtíš District of the Banská Bystrica Region of southern Slovakia.
External links
http://www.statistics.sk/mosmis/eng/run.html
Villages and municipalities in Veľký Krtíš District
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https://en.wikipedia.org/wiki/List%20of%20career%20achievements%20by%20Michael%20Jordan
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This page details statistics, records, and other achievements pertaining to Michael Jordan.
College statistics
The three-point line did not exist during Michael Jordan's freshman and junior seasons in North Carolina in the NCAA. During his sophomore season, the three-point line was tested within ACC play. Many other conferences also tested with the line during this season, but again, only within their respective conference competition.
Averages
Totals
NBA career statistics
Averages
Totals
Source: basketball-reference.com and nba.com
Playoffs
Source: basketball-reference.com
Awards and accomplishments
NBA achievements
Naismith Memorial Basketball Hall of Fame Class of 2009
6× NBA champion: 1991, 1992, 1993, 1996, 1997, 1998
5× NBA Most Valuable Player: 1987–88, 1990–91, 1991–92, 1995–96, 1997–98
6× NBA Finals Most Valuable Player: 1991, 1992, 1993, 1996, 1997, 1998
10× Scoring leader: 1986–87, 1987–88, 1988–89, 1989–90, 1990–91, 1991–92, 1992–93, 1995–96, 1996–97, 1997–98
NBA Defensive Player of the Year: 1987–88
NBA Rookie of the Year: 1984–85
14× NBA All-Star: 1985, 1986 (selected but injured), 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1996, 1997, 1998, 2002, 2003
3× NBA All-Star Game Most Valuable Player: 1988, 1996, 1998
2× NBA Slam Dunk Contest champion: 1987, 1988
Runner-up in 1985
3× Steals leader: 1987–88, 1989–90, 1992–93
2× Minutes leader: 1987–88, 1988–89
2× IBM Award winner: 1985, 1989
11× All-NBA selection:
First Team: 1987–93, 1996
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https://en.wikipedia.org/wiki/Kindler%20syndrome
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Kindler syndrome (also known as "bullous acrokeratotic poikiloderma of Kindler and Weary",) is a rare congenital disease of the skin caused by a mutation in the KIND1 gene.
Symptoms and signs
Infants and young children with Kindler syndrome have a tendency to blister with minor trauma and are prone to sunburns. As individuals with Kindler syndrome age, they tend to have fewer problems with blistering and photosensitivity. However, pigment changes and thinning of the skin become more prominent. Kindler syndrome can affect various mucous tissues such as the mouth and eyes, which can lead to other health problems.
Genetics
Kindler syndrome is an autosomal recessive genodermatosis. The KIND1 gene mutated in Kindler syndrome codes for the protein kindlin-1, which is thought to be active in the interactions between actin and the extracellular matrix (focal adhesion plaques). Kindler syndrome was first described in 1954 by Theresa Kindler.
Diagnosis
Clinical and genetic tests are used to confirm diagnosis.
Management
Treatment may involve several different types of practitioner to address the various manifestations that may occur. This multidisciplinary team will also be involved in preventing secondary complications.
See also
Rothmund–Thomson syndrome
Epidermolysis bullosa
List of cutaneous conditions
References
External links
Genodermatoses
Rare syndromes
Autosomal recessive disorders
Papulosquamous hyperkeratotic cutaneous conditions
Syndromes affecting the skin
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https://en.wikipedia.org/wiki/Don%27t%20It%20Make%20My%20Brown%20Eyes%20Blue
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"Don't It Make My Brown Eyes Blue" is a song written by Richard Leigh, and recorded by American country music singer Crystal Gayle. It was released in June 1977 as the first single from Gayle's album We Must Believe in Magic.
Background
"Don't It Make My Brown Eyes Blue" composer Richard Leigh had been responsible for all three of Crystal Gayle's previous Top Ten C&W hits, the third of which "I'll Get Over You" had reached number 1. According to Gayle's regular producer Allen Reynolds, he was advised by Leigh's landlady, songwriter Sandy Mason Theoret, that Leigh was "a little down in the dumps lately because nothing much [was] happening" after the success of "I'll Get Over You". At Theoret's suggestion, Reynolds visited Leigh to cheer him up. Reynolds explained, "we were sittin' on the floor...singing songs to one another. [Leigh] mentioned a song that his publisher was gonna get to Shirley Bassey...[and] sang it for me: 'Don't It Make My Brown Eyes Blue'. I said, 'Shirley Bassey my ass, I want that song!'" Reynolds recalls that when he played "Don't It Make My Brown Eyes Blue" for Gayle "she was just as excited [by the song] as I was."
The track was recorded at Jack's Tracks in Nashville on October 27, 1976. As Reynolds' regular session keyboardist Charles Cochran had suffered a stroke with some resultant numbness in his hands, Reynolds hired Hargus "Pig" Robbins to play keyboards, and Robbins instantly devised the song's signature acoustic piano riff; Cochran was als
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https://en.wikipedia.org/wiki/Metering%20pump
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A metering pump moves a precise volume of liquid in a specified time period providing an accurate volumetric flow rate.
Delivery of fluids in precise adjustable flow rates is sometimes called metering. The term "metering pump" is based on the application or use rather than the exact kind of pump used, although a couple types of pumps are far more suitable than most other types of pumps.
Although metering pumps can pump water, they are often used to pump chemicals, solutions, or other liquids. Many metering pumps are rated to be able to pump into a high discharge pressure. They are typically made to meter at flow rates which are practically constant (when averaged over time) within a wide range of discharge (outlet) pressure. Manufacturers provide each of their models of metering pumps with a maximum discharge pressure rating against which each model is guaranteed to be able to pump against. An engineer, designer, or user should ensure that the pressure and temperature ratings and wetted pump materials are compatible for the application and the type of liquid being pumped.
Most metering pumps have a pump head and a motor. The liquid being pumped goes through the pump head, entering through an inlet line and leaving through an outlet line. The motor is commonly an electric motor which drives the pump head.
Dispensing pump
Some metering pumps can be used for dispensing. A metering pump is designed to deliver a continuous rate of flow, however, a dispensing pump is
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https://en.wikipedia.org/wiki/LIPC
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LIPC can refer to:
Electrolaser (Laser-Induced Plasma Channel)
LIPC gene encoding hepatic lipase
The ICAO code for Cervia Air Force Base
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https://en.wikipedia.org/wiki/Phase%20offset%20modulation
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Phase offset modulation works by overlaying two instances of a periodic waveform on top of each other. (In software synthesis, the waveform is usually generated by using a lookup table.) The two instances of the waveform are kept slightly out of sync with each other, as one is further ahead or further behind in its cycle. The values of both of the waveforms are either multiplied together, or the value of one is subtracted from the other.
This generates an entirely new waveform with a drastically different shape. For example, one sawtooth (ramp) wave subtracted from another will create a pulse wave, with the amount of offset (i.e. the difference between the two waveforms' starting points) dictating the duty cycle. If you slowly change the offset amount, you create pulse-width modulation.
Using this technique, not only can a ramp wave create pulsewidth modulation, but any other waveform can achieve a comparable effect.
Wave mechanics
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https://en.wikipedia.org/wiki/Surface%20reconstruction
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Surface reconstruction refers to the process by which atoms at the surface of a crystal assume a different structure than that of the bulk. Surface reconstructions are important in that they help in the understanding of surface chemistry for various materials, especially in the case where another material is adsorbed onto the surface.
Basic principles
In an ideal infinite crystal, the equilibrium position of each individual atom is determined by the forces exerted by all the other atoms in the crystal, resulting in a periodic structure. If a surface is introduced to the surroundings by terminating the crystal along a given plane, then these forces are altered, changing the equilibrium positions of the remaining atoms. This is most noticeable for the atoms at or near the surface plane, as they now only experience inter-atomic forces from one direction. This imbalance results in the atoms near the surface assuming positions with different spacing and/or symmetry from the bulk atoms, creating a different surface structure. This change in equilibrium positions near the surface can be categorized as either a relaxation or a reconstruction.
Relaxation refers to a change in the position of surface atoms relative to the bulk positions, while the bulk unit cell is preserved at the surface. Often this is a purely normal relaxation: that is, the surface atoms move in a direction normal to the surface plane, usually resulting in a smaller-than-usual inter-layer spacing. This makes int
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https://en.wikipedia.org/wiki/Simply%20the%20Best
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Simply the Best may refer to:
Music
Simply the Best (Art Garfunkel album), 1998
Simply the Best (Crystal Lewis album)
Simply the Best (Tina Turner album), 1991
"The Best" (song), also known as "Simply the Best", a 1988 song recorded by Bonnie Tyler and later covered by Tina Turner
"Simply the Best" (song), 2022
Simply the Best, a 2006 mixtape by Scorcher
"Simply the Best", from the television series Schitt's Creek, covered by Noah Reid
Other uses
Simply the Best (game show), a British game show
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https://en.wikipedia.org/wiki/Concordant%20pair
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In statistics, a concordant pair is a pair of observations, each on two variables, (X1,Y1) and (X2,Y2), having the property that
where "sgn" refers to whether a number is positive, zero, or negative (its sign). Specifically, the signum function, often represented as sgn, is defined as:
That is, in a concordant pair, both elements of one pair are either greater than, equal to, or less than the corresponding elements of the other pair.
In contrast, a discordant pair is a pair of two-variable observations such that
That is, if one pair contains a higher value of X then the other pair contains a higher value of Y.
Uses
The Kendall tau distance between two series is the total number of discordant pairs. The Kendall tau rank correlation coefficient, which measures how closely related two series of numbers are, is proportional to the difference between the number of concordant pairs and the number of discordant pairs. An estimate of Goodman and Kruskal's gamma, another measure of rank correlation, is given by the ratio of the difference to the sum of the numbers of concordant and discordant pairs. Somers' D is another similar but asymmetric measure given by the ratio of the difference in the number of concordant and discordant pairs to the number of pairs with unequal values for one of the two variables.
See also
Spearman's rank correlation coefficient
References
Abdi, Hervé (2007). "The Kendall Rank Correlation Coefficient". In: Neil Salkind (Ed.), Encyclopedia of Mea
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https://en.wikipedia.org/wiki/Artificial%20transcription%20factor
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Artificial transcription factors (ATFs) are engineered individual or multi molecule transcription factors that either activate or repress gene transcription (biology).
ATFs often contain two main components linked together, a DNA-binding domain and a regulatory domain, also known as an effector domain or modulatory domain. The DNA-binding domain targets a specific DNA sequence with high affinity, and the regulatory domain is responsible for activating or repressing the bound gene. The ATF can directly regulate gene expression, can recruit proteins and other transcription factors to initiate transcription, or recruit proteins and other transcription factors to compact the DNA which inhibits RNA polymerase from binding and transcribing the DNA; an example of transcription factors up-regulating gene expression is displayed in figure 1 on the left. Because ATFs are composed of two separable components, the DNA-binding domain and the regulatory domain, the two domains are interchangeable, permitting the design of new ATFs from existing natural transcription factors.
Some applications of ATFs include reprogramming cell state, cancer treatment, and a plausible treatment for Angelman Syndrome.
ATF Design
DNA-Binding Domain
The DNA-binding domain routes the ATF to a specific gene sequence. Natural DNA binding proteins are commonly used because of their high affinity for their DNA target sequence, however currently no algorithm that matches the protein amino-acid sequence to the
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https://en.wikipedia.org/wiki/Target-site%20overlap
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In a zinc finger protein, certain sequences of amino acid residues are able to recognise and bind to an extended target-site of four or even five nucleotides When this occurs in a ZFP in which the three-nucleotide subsites are contiguous, one zinc finger interferes with the target-site of the zinc finger adjacent to it, a situation known as target-site overlap. For example, a zinc finger containing arginine at position -1 and aspartic acid at position 2 along its alpha-helix will recognise an extended sequence of four nucleotides of the sequence 5'-NNG(G/T)-3'. The hydrogen bond between Asp2 and the N4 of either a cytosine or adenine base paired to the guanine or thymine, respectively defines these two nucleotides at the 3' position, defining a sequence that overlaps into the subsite of any zinc finger that may be attached N-terminally.
Target-site overlap limits the modularity of those zinc fingers which exhibit it, by restricting the number of situations to which they can be applied. If some of the zinc fingers are restricted in this way, then a larger repertoire is required to address the situations in which those zinc fingers cannot be used. Target-site overlap may also affect the selection of zinc fingers during by display, in cases where amino acids on a non-randomised finger, and the bases of its associated subsite, influence the binding of residues on the adjacent finger which contains the randomised residues. Indeed, attempts to derive zinc finger proteins targeting
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https://en.wikipedia.org/wiki/Ko%20Ko%20Mo%20%28I%20Love%20You%20So%29
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"Ko Ko Mo (I Love You So)" is a popular rock novelty song written in late 1954 by the rhythm and blues partnership of Forest Gene Wilson and Eunice Levy, and also credited to Jake Porter. One of the earliest rock and roll songs, it was probably "the most extensively recorded rock 'n' roll song of that time".
Originally recorded by rhythm and blues duo Gene and Eunice (Wilson and Levy) in November 1954 on the Combo label and again in January 1955 on the Aladdin label, it was covered by at least 17 different musicians in the first few months of 1955 alone, including Perry Como, The Crew-Cuts, The Charms, Louis Armstrong and Gary Crosby, Goldie Hill & Red Sovine, Hawkshaw Hawkins and Rita Robbins, The Hutton Sisters (Marion Hutton and Betty Hutton), The Flamingos, Ronnie Aldrich and The Squads, Tito Rodríguez, Big Dave and His Orchestra, Marvin & Johnny, Barry Frank (with the Four Bells), Bill Darnell & Betty Clooney, Jack Cardwell with Jackie Hill, and The Dooley Sisters. Andy Griffith also recorded a satirical parody of the song.
The song spent 15 weeks in the Billboard charts from January to May 1955, and peaked at #3 in its Honor Roll of Hits in the week ending March 2, 1955. The version by Perry Como, RCA's first rock 'n' roll release, was the most successful, reaching #2 on the Billboard charts in February 1955, while a version by The Crew-Cuts reached #6 on the Pop charts that same month. Gene and Eunice's two versions were on the charts for 7 weeks and reached #6 on t
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https://en.wikipedia.org/wiki/Endoglin
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Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations in the body.
Gene and expression
The human endoglin gene is located on human chromosome 9 with location of the cytogenic band at 9q34.11. Endoglin glycoprotein is encoded by 39,757 bp and translates into 658 amino acids.
The expression of the endoglin gene is usually low in resting endothelial cells. This, however, changes once neoangiogenesis begins and endothelial cells become active in places like tumor vessels, inflamed tissues, skin with psoriasis, vascular injury and during embryogenesis. The expression of the vascular system begins at about 4 weeks and continues after that. Other cells in which endoglin is expressed consist of monocytes, especially those transitioning into macrophages, low expression in normal smooth muscle cells, high expression vascular smooth muscle cells and in kidney and liver tissues undergoing fibrosis.
Structure
The glycoprotein consists of a homodimer of 180 kDA stabilized by intermolecular disulfide bonds. It has a large extracellular domain of about 561 amino acids, a hydrophobic transmembrane domain and a short cytoplasmic tail domain composed of 45 amino acids. The 260 amino acid reg
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https://en.wikipedia.org/wiki/Gibbs%E2%80%93Donnan%20effect
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The Gibbs–Donnan effect (also known as the Donnan's effect, Donnan law, Donnan equilibrium, or Gibbs–Donnan equilibrium) is a name for the behaviour of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane. The usual cause is the presence of a different charged substance that is unable to pass through the membrane and thus creates an uneven electrical charge. For example, the large anionic proteins in blood plasma are not permeable to capillary walls. Because small cations are attracted, but are not bound to the proteins, small anions will cross capillary walls away from the anionic proteins more readily than small cations.
Thus, some ionic species can pass through the barrier while others cannot. The solutions may be gels or colloids as well as solutions of electrolytes, and as such the phase boundary between gels, or a gel and a liquid, can also act as a selective barrier. The electric potential arising between two such solutions is called the Donnan potential.
The effect is named after the American physicist Josiah Willard Gibbs who proposed it in 1878 and the British chemist Frederick G. Donnan who studied it experimentally in 1911.
The Donnan equilibrium is prominent in the triphasic model for articular cartilage proposed by Mow and Lai, as well as in electrochemical fuel cells and dialysis.
The Donnan effect is tactic pressure attributable to cations (Na+ and K+) attached to dissolved plasma
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https://en.wikipedia.org/wiki/La%20Job
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La Job is a Canadian French-language comedy television series set in Montreal, Quebec. It is an adaptation of the British show The Office. Produced by Anne-Marie Losique's Image Diffusion International, it has been broadcast for a limited number of viewers on Bell Satellite TV satellite television, beginning on October 9, 2006. It was later seen by a wider audience on the public broadcaster Radio-Canada (starting in January 2007) and specialty channel ARTV (starting in the third quarter of the same year). It is the third official foreign adaptation of the concept, and the second in a language other than English.
Synopsis
National industry leader Les Papiers Jennings, a multinational carton and packaging company, is restructuring. The regional manager of their branch on Côte-de-Liesse, Saint-Laurent, in Montreal, is David Gervais (the name is an homage to Ricky Gervais, and his original character David Brent). He will need to compete with the Terrebonne branch and operate an important effort to avoid the shut-down of their branch. He will also have to cope with occasionally rebellious employees.
David is a failed comedian and rocker who also fails to grasp the notion of political correctness. He tends to either make a fool of himself in front of the office crew or make it intensely uncomfortable. The one who seems to enjoy him the most is Sam Bisaillon, former army cadet who worships David. He shares his desk with Louis Tremblay, who is secretly in love with the shy recepti
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https://en.wikipedia.org/wiki/Charlie-class%20submarine
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The Project 670 Skat submarine (NATO classification Charlie class) was a nuclear-powered cruise missile submarine built for the Soviet Navy and later operated by the Russian Navy. All Charlie I/II-class submarines are decommissioned. One Charlie-class submarine was used for testing an Oniks missile. Charlie I and its successor Charlie II-class submarines are designed by the Lazurit Central Design Bureau of Gorky.
Background
The Charlie I-class submarine (Project 670 Skat) SSGN was first launched at the Krasnoye Sormovo inland shipyard at Gorkiy in 1967 with another ten following over a period of five years. The Charlie Is had two banks of four missile tubes angled upwards on each side of the bow outside the pressure hull. The tubes were covered by large outer doors and the design was to incorporate the P-120 Malakhit (SS-N-9 Siren) medium-range anti-ship missile. Due to delays in the missile development, the missile was substituted with the shorter range P-70 Ametist (SS-N-7 Starbright) submerged launch missile which itself was a development of the P-15 Termit (SS-N-2 Styx) surface-launched missile. The missiles were designed for pop up surprise attacks on high value surface targets such as aircraft carriers.
In 1972 to 1979, six improved units called the Project 670M Skat-M (Charlie II class) were built. The improved Charlie IIs were built at Gorkiy with an insert in the hull forward of the fin. The insert incorporated electronics and launch systems for targeting and firi
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