Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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positive regulation of MHC class II biosynthetic process positive regulation of transcription by RNA polymerase II Ras protein signal transduction regulation of transcription by RNA polymerase II | cytosol; intercellular bridge; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex | DNA binding histone deacetylase binding | Homo sapiens | 3D-structure Activator Alternative splicing ANK repeat Cytoplasm Direct protein sequencing Disease variant DNA-binding Nucleus Reference proteome Repeat SCID Transcription Transcription regulation | MELTQPAEDL | MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE | positive regulation of MHC class II biosynthetic process positive regulation of transcription by RNA polymerase II Ras protein signal transduction regulation of transcription by RNA polymerase II cytosol; intercellular bridge; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex DNA binding histone d... |
negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation protein dephosphorylation | nucleoplasm | metal ion binding myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity | Homo sapiens | 3D-structure Hydrolase Magnesium Metal-binding Nucleus Phosphoprotein Protein phosphatase Reference proteome | MEHGSIITQA | MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP | negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation protein dephosphorylation nucleoplasm metal ion binding myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity Homo sapiens 3D-structure Hydrolase Magnesium Metal-binding Nucle... |
G protein-coupled receptor signaling pathway phototransduction | heterotrimeric G-protein complex | G-protein beta-subunit binding GTPase activity | Homo sapiens | Cell membrane Lipoprotein Membrane Methylation Prenylation Reference proteome Transducer | MAQDLSEKDL | MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS | G protein-coupled receptor signaling pathway phototransduction heterotrimeric G-protein complex G-protein beta-subunit binding GTPase activity Homo sapiens Cell membrane Lipoprotein Membrane Methylation Prenylation Reference proteome Transducer MAQDLSEKDL MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKG... |
actin cytoskeleton organization actin filament organization cellular response to type II interferon positive regulation of actin filament polymerization positive regulation of protein-containing complex assembly positive regulation of pseudopodium assembly regulation of cell shape Rho protein signal transduction | cytoplasm; cytoskeleton; cytosol; endomembrane system; membrane; microtubule cytoskeleton; phagocytic vesicle; plasma membrane | GTPase activator activity opioid peptide activity small GTPase binding | Homo sapiens | Acetylation Cell shape Cytoplasm Cytoskeleton Membrane Phosphoprotein Reference proteome | MSTKVPIYLK | MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT | actin cytoskeleton organization actin filament organization cellular response to type II interferon positive regulation of actin filament polymerization positive regulation of protein-containing complex assembly positive regulation of pseudopodium assembly regulation of cell shape Rho protein signal transduction cytopl... |
cellular response to oxidative stress protein maturation by copper ion transfer removal of superoxide radicals superoxide metabolic process | cytoplasm; cytosol; nucleus | cadherin binding copper ion binding protein-disulfide reductase activity superoxide dismutase copper chaperone activity | Homo sapiens | 3D-structure Chaperone Copper Cytoplasm Disulfide bond Isopeptide bond Metal-binding Phosphoprotein Reference proteome Ubl conjugation Zinc | MASDSGNQGT | MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL | cellular response to oxidative stress protein maturation by copper ion transfer removal of superoxide radicals superoxide metabolic process cytoplasm; cytosol; nucleus cadherin binding copper ion binding protein-disulfide reductase activity superoxide dismutase copper chaperone activity Homo sapiens 3D-structure Chaper... |
adenylate cyclase-activating G protein-coupled receptor signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide cell-cell signaling cellular response to lipopolysaccharide chemokine-mediated signaling pathway chemotaxis inflammatory response neutrophil chemotaxis positive regulation of... | extracellular region; extracellular space | chemokine activity CXCR chemokine receptor binding CXCR3 chemokine receptor binding heparin binding | Homo sapiens | 3D-structure Chemotaxis Citrullination Cytokine Direct protein sequencing Disulfide bond Inflammatory response Reference proteome Secreted Signal | MSVKGMAIAL | MSVKGMAIALAVILCATVVQGFPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF | adenylate cyclase-activating G protein-coupled receptor signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide cell-cell signaling cellular response to lipopolysaccharide chemokine-mediated signaling pathway chemotaxis inflammatory response neutrophil chemotaxis positive regulation of... |
animal organ morphogenesis anterior/posterior axis specification blood vessel development cell differentiation labyrinthine layer development negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specif... | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MYGSCLLEKE | MYGSCLLEKEAGMYPGTLMSPGGDGTAGTGGTGGGGSPMPASNFAAAPAFSHYMGYPHMPSMDPHWPSLGVWGSPYSPPREDWSVYPGPSSTMGTVPVNDVTSSPAAFCSTDYSNLGPVGGGTSGSSLPGQAGGSLVPTDAGAAKASSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVVYTDHQRLELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENSGGSVQSDSDSISPGELPNTFFTTPSAVRGFQPIEIQQVIVSE | animal organ morphogenesis anterior/posterior axis specification blood vessel development cell differentiation labyrinthine layer development negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; nu... |
regulation of DNA-templated transcription | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding | Homo sapiens | Acetylation Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MTLLTFRDVA | MTLLTFRDVAIEFSLEEWKCLDLAQQNLYRDVMLENYRNLFSVGLTVCKPGLITCLEQRKEPWNVKRQEAADGHPEMGFHHATQACLELLGSSDLPASASQSAGITGVNHRAQPGLNVSVDKFTALCSPGVLQTVKWFLEFRCIFSLAMSSHFTQDLLPEQGIQDAFPKRILRGYGNCGLDNLYLRKDWESLDECKLQKDYNGLNQCSSTTHSKIFQYNKYVKIFDNFSNLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQCSHFTEPENIDTGEKPYKCQECNNVIKTCSVLTKNRI... | regulation of DNA-templated transcription nucleus DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding Homo sapiens Acetylation Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteom... |
ATP metabolic process basophil activation involved in immune response negative regulation of inflammatory response negative regulation of mast cell activation involved in immune response negative regulation of mast cell proliferation nucleoside triphosphate catabolic process phosphate ion homeostasis phosphate-containi... | apical plasma membrane; external side of plasma membrane; extracellular exosome; perinuclear region of cytoplasm | calcium ion binding nucleic acid binding nucleoside triphosphate diphosphatase activity phosphodiesterase I activity zinc ion binding | Homo sapiens | 3D-structure Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Membrane Metal-binding Reference proteome Repeat Secreted Signal-anchor Transmembrane Transmembrane helix Zinc | MESTLTLATE | MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMY... | ATP metabolic process basophil activation involved in immune response negative regulation of inflammatory response negative regulation of mast cell activation involved in immune response negative regulation of mast cell proliferation nucleoside triphosphate catabolic process phosphate ion homeostasis phosphate-containi... |
animal organ morphogenesis cilium assembly cytoskeleton organization lamellipodium assembly visual perception | actin cytoskeleton; cytoplasm; lamellipodium; stress fiber | actin binding actin filament binding metal ion binding | Homo sapiens | Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoskeleton Isopeptide bond LIM domain Metal-binding Phosphoprotein Reference proteome Repeat Ubl conjugation Zinc | MPAFLGLKCL | MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNRKRLIVEDRRVSGTSFTAHRRATITHLLYLCPKDYCPRGRVCNSVDPFVAHPQDPHHPSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTE... | animal organ morphogenesis cilium assembly cytoskeleton organization lamellipodium assembly visual perception actin cytoskeleton; cytoplasm; lamellipodium; stress fiber actin binding actin filament binding metal ion binding Homo sapiens Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoskeleton Isopeptide bo... |
canonical Wnt signaling pathway cochlea morphogenesis convergent extension involved in neural plate elongation heart development heart looping intracellular signal transduction neural tube closure non-canonical Wnt signaling pathway outflow tract morphogenesis planar cell polarity pathway involved in neural tube closur... | aggresome; apical part of cell; clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; nuclear body; nucleoplasm; nucleus | frizzled binding identical protein binding protein domain specific binding protein kinase binding protein self-association protein-macromolecule adaptor activity small GTPase binding | Homo sapiens | 3D-structure Cell membrane Cytoplasm Cytoplasmic vesicle Developmental protein Membrane Nucleus Phosphoprotein Reference proteome Wnt signaling pathway | MAGSSTGGGG | MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQV... | canonical Wnt signaling pathway cochlea morphogenesis convergent extension involved in neural plate elongation heart development heart looping intracellular signal transduction neural tube closure non-canonical Wnt signaling pathway outflow tract morphogenesis planar cell polarity pathway involved in neural tube closur... |
sperm flagellum assembly | 9+2 motile cilium; axoneme; cilium; cytoplasm; dynein axonemal particle; dynein complex; filopodium; motile cilium; sperm flagellum | dynein heavy chain binding | Homo sapiens | 3D-structure Alternative splicing Cell projection Cilium Coiled coil Cytoplasm Dynein Flagellum Motor protein Reference proteome | MIPPADSLLK | MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK | sperm flagellum assembly 9+2 motile cilium; axoneme; cilium; cytoplasm; dynein axonemal particle; dynein complex; filopodium; motile cilium; sperm flagellum dynein heavy chain binding Homo sapiens 3D-structure Alternative splicing Cell projection Cilium Coiled coil Cytoplasm Dynein Flagellum Motor protein Reference pro... |
cellular response to hypoxia cellular response to zinc ion chemical synaptic transmission cochlea development monoatomic ion transmembrane transport negative regulation of cytosolic calcium ion concentration potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential response ... | plasma membrane; synapse | monoatomic ion channel activity open rectifier potassium channel activity outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity S100 protein binding | Homo sapiens | 3D-structure Cell membrane Disease variant Glycoprotein Ion channel Ion transport Membrane Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport | MKRQNVRTLA | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREK... | cellular response to hypoxia cellular response to zinc ion chemical synaptic transmission cochlea development monoatomic ion transmembrane transport negative regulation of cytosolic calcium ion concentration potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential response ... |
intra-Golgi vesicle-mediated transport protein transport vesicle fusion | cytosol; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi membrane; late endosome membrane; membrane; nucleoplasm; SNARE complex | SNAP receptor activity SNARE binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Coiled coil Congenital muscular dystrophy Direct protein sequencing Disease variant Endoplasmic reticulum Epilepsy Golgi apparatus Membrane Neurodegeneration Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MDPLFQQTHK | MDPLFQQTHKQVHEIQSCMGRLETADKQSVHIVENEIQASIDQIFSRLERLEILSSKEPPNKRQNARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT | intra-Golgi vesicle-mediated transport protein transport vesicle fusion cytosol; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi membrane; late endosome membrane; membrane; nucleoplasm; SNARE complex SNAP recep... |
cell adhesion chaperone cofactor-dependent protein refolding chaperone-mediated protein folding ER-associated misfolded protein catabolic process intermediate filament cytoskeleton organization neuron projection development nuclear envelope organization nuclear membrane organization organelle organization positive regu... | cytoplasmic vesicle membrane; cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; growth cone; intracellular membrane-bounded organelle; membrane; nuclear envelope; nuclear membrane; secretory granule; synaptic vesicle | ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone cytoskeletal protein binding identical protein binding kinesin binding misfolded protein binding unfolded protein binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell projection Chaperone Cytoplasm Cytoplasmic vesicle Cytoskeleton Disease variant Dystonia Endoplasmic reticulum Glycoprotein Hydrolase Membrane Nucleotide-binding Nucleus Reference proteome Signal Synapse | MKLGRAVLGL | MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREALQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRVAEEMTFFPKEERVFSDKGCK... | cell adhesion chaperone cofactor-dependent protein refolding chaperone-mediated protein folding ER-associated misfolded protein catabolic process intermediate filament cytoskeleton organization neuron projection development nuclear envelope organization nuclear membrane organization organelle organization positive regu... |
chaperone cofactor-dependent protein refolding endoplasmic reticulum organization nuclear membrane organization protein localization to nucleus response to unfolded protein | endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; nuclear envelope; nuclear membrane | ATP binding ATP hydrolysis activity identical protein binding kinesin binding | Homo sapiens | ATP-binding Chaperone Endoplasmic reticulum Glycoprotein Hydrolase Membrane Nucleotide-binding Nucleus Reference proteome Signal | MLRAGWLRGA | MLRAGWLRGAAALALLLAARVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREERPLNASALKLDLEEKLFGQHLATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQLKDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRVAEEMTFFPRDEKI... | chaperone cofactor-dependent protein refolding endoplasmic reticulum organization nuclear membrane organization protein localization to nucleus response to unfolded protein endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; nuclear envelope; nuclear membrane ATP binding ATP hydrolysis activity i... |
endocytic recycling intracellular protein transport retrograde transport, endosome to Golgi vesicle docking vesicle fusion | cytoplasm; cytosol; endomembrane system; focal adhesion; Golgi apparatus; Golgi cisterna; Golgi membrane; intracellular membrane-bounded organelle; membrane; perinuclear region of cytoplasm; SNARE complex; synaptic vesicle membrane; trans-Golgi network; trans-Golgi network membrane | SNAP receptor activity SNARE binding syntaxin binding | Homo sapiens | Alternative splicing Coiled coil Cytoplasm Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MATRRLTDAF | MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHITSSPLHSRSIAAELDELADDRMALVSGISLDPEAAIGVTKRPPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRARACSEQEGRLLGNVVASLAQALQELSTSFRHAQSGYLKRMKNREERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKMLVILILFVIIIVLIVVLV... | endocytic recycling intracellular protein transport retrograde transport, endosome to Golgi vesicle docking vesicle fusion cytoplasm; cytosol; endomembrane system; focal adhesion; Golgi apparatus; Golgi cisterna; Golgi membrane; intracellular membrane-bounded organelle; membrane; perinuclear region of cytoplasm; SNARE ... |
cellular response to leukemia inhibitory factor cobalamin metabolic process cobalamin transport fatty acid beta-oxidation long-chain fatty acid import into peroxisome peroxisome organization transmembrane transport very long-chain fatty acid catabolic process | ATP-binding cassette (ABC) transporter complex; endoplasmic reticulum membrane; lysosomal membrane; membrane; peroxisomal membrane; peroxisome | ABC-type vitamin B12 transporter activity ATP binding ATP hydrolysis activity ATPase-coupled transmembrane transporter activity identical protein binding long-chain fatty acid transporter activity | Homo sapiens | 3D-structure ATP-binding Disease variant Endoplasmic reticulum Lysosome Membrane Nucleotide-binding Reference proteome Translocase Transmembrane Transmembrane helix Transport | MAVAGPAPGA | MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYL... | cellular response to leukemia inhibitory factor cobalamin metabolic process cobalamin transport fatty acid beta-oxidation long-chain fatty acid import into peroxisome peroxisome organization transmembrane transport very long-chain fatty acid catabolic process ATP-binding cassette (ABC) transporter complex; endoplasmic ... |
apoptotic process macroautophagy negative regulation of cell growth | cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; nuclear membrane | importin-alpha family protein binding | Homo sapiens | Acetylation Alternative splicing Apoptosis Autophagy Cytoplasm Disease variant Endoplasmic reticulum Membrane Nucleus Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MADSVKTFLQ | MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRRASSVLAQRRAQSIERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTS... | apoptotic process macroautophagy negative regulation of cell growth cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; nuclear membrane importin-alpha family protein binding Homo sapiens Acetylation Alternative splicing Apoptosis Autophagy Cytoplasm Disease variant Endoplasmic re... |
negative regulation of translation nervous system development positive regulation of neuron projection development proteasomal ubiquitin-independent protein catabolic process protein ubiquitination | chromatin; Cul3-RING ubiquitin ligase complex; cytoplasm; cytoskeleton; neuronal cell body; nuclear matrix; nucleoplasm; nucleus | actin binding | Homo sapiens | Actin-binding Alternative splicing Cytoplasm Cytoskeleton Developmental protein Kelch repeat Nucleus Reference proteome Repeat Ubl conjugation | MSVSVHENRK | MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEI... | negative regulation of translation nervous system development positive regulation of neuron projection development proteasomal ubiquitin-independent protein catabolic process protein ubiquitination chromatin; Cul3-RING ubiquitin ligase complex; cytoplasm; cytoskeleton; neuronal cell body; nuclear matrix; nucleoplasm; n... |
cell population proliferation negative regulation of cell population proliferation positive regulation of prostaglandin secretion prostaglandin biosynthetic process prostaglandin metabolic process regulation of fever generation regulation of inflammatory response sensory perception of pain signal transduction | endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm | glutathione binding glutathione peroxidase activity glutathione transferase activity prostaglandin-D synthase activity prostaglandin-E synthase activity | Homo sapiens | 3D-structure Cytoplasm Fatty acid biosynthesis Fatty acid metabolism Isomerase Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Prostaglandin biosynthesis Prostaglandin metabolism Reference proteome Transferase Transmembrane Transmembrane helix | MPAHSLVMSS | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL | cell population proliferation negative regulation of cell population proliferation positive regulation of prostaglandin secretion prostaglandin biosynthetic process prostaglandin metabolic process regulation of fever generation regulation of inflammatory response sensory perception of pain signal transduction endoplasm... |
response to amphetamine tRNA methylation tRNA modification tRNA stabilization | cytoplasm; nucleoplasm; nucleus | RNA binding tRNA (cytidine-5-)-methyltransferase activity tRNA methyltransferase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Methyltransferase Reference proteome RNA-binding S-adenosyl-L-methionine Transferase tRNA processing | MEPLRVLELY | MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIY... | response to amphetamine tRNA methylation tRNA modification tRNA stabilization cytoplasm; nucleoplasm; nucleus RNA binding tRNA (cytidine-5-)-methyltransferase activity tRNA methyltransferase activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Methyltransferase Reference proteome RNA-binding S-adenosyl-L-m... |
cellular response to dsDNA cellular response to dsRNA cellular response to virus chromosome segregation defense response to virus innate immune response maturation of SSU-rRNA negative regulation of canonical NF-kappaB signal transduction negative regulation of MDA-5 signaling pathway negative regulation of protein-con... | cytosol; preribosome, small subunit precursor | ATP binding caspase binding metal ion binding protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | Alternative splicing Antiviral defense ATP-binding Cytoplasm Immunity Innate immunity Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Ribosome biogenesis Serine/threonine-protein kinase Transferase | MDLVGVASPE | MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVAVAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLN... | cellular response to dsDNA cellular response to dsRNA cellular response to virus chromosome segregation defense response to virus innate immune response maturation of SSU-rRNA negative regulation of canonical NF-kappaB signal transduction negative regulation of MDA-5 signaling pathway negative regulation of protein-con... |
inositol biosynthetic process inositol metabolic process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process response to lithium ion signal transduction | cytoplasm; cytosol | inositol monophosphate 1-phosphatase activity inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity metal ion binding protein homodimerization activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Hydrolase Magnesium Metal-binding Reference proteome | MKPSGEDQAA | MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK | inositol biosynthetic process inositol metabolic process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process response to lithium ion signal transduction cytoplasm; cytosol inositol monophosphate 1-phosphatase activity inositol monophosphate 3-phosphatase activity inositol... |
apoptotic process cellular response to interleukin-1 cellular response to lipopolysaccharide cellular senescence Fc-epsilon receptor signaling pathway JNK cascade phosphorylation positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive r... | cytoplasm; cytosol; nucleus | ATP binding enzyme binding JUN kinase kinase activity magnesium ion binding MAP kinase activity MAP kinase kinase activity molecular function activator activity protein kinase binding protein phosphatase binding protein serine kinase activity protein tyrosine kinase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis ATP-binding Coiled coil Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Stress response Transferase Tyrosine-protein kinase | MAASSLEQKL | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF... | apoptotic process cellular response to interleukin-1 cellular response to lipopolysaccharide cellular senescence Fc-epsilon receptor signaling pathway JNK cascade phosphorylation positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive r... |
acyl-CoA metabolic process alpha-linolenic acid metabolic process bile acid biosynthetic process dicarboxylic acid catabolic process fatty acid beta-oxidation using acyl-CoA oxidase fatty acid catabolic process negative regulation of CD4 production peroxisome fission | cytosol; peroxisomal matrix | acetoacetyl-CoA hydrolase activity acetyl-CoA hydrolase activity acyl-CoA hydrolase activity carboxylic ester hydrolase activity choloyl-CoA hydrolase activity CoA hydrolase activity glutaryl-CoA hydrolase activity hydroxymethylglutaryl-CoA hydrolase activity medium-chain acyl-CoA hydrolase activity myristoyl-CoA hydro... | Homo sapiens | Fatty acid metabolism Host-virus interaction Hydrolase Lipid metabolism Peroxisome Peroxisome biogenesis Reference proteome Serine esterase | MSSPQAPEDG | MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL | acyl-CoA metabolic process alpha-linolenic acid metabolic process bile acid biosynthetic process dicarboxylic acid catabolic process fatty acid beta-oxidation using acyl-CoA oxidase fatty acid catabolic process negative regulation of CD4 production peroxisome fission cytosol; peroxisomal matrix acetoacetyl-CoA hydrolas... |
phosphatidylinositol biosynthetic process | endoplasmic reticulum membrane; Golgi apparatus; membrane; plasma membrane | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity metal ion binding | Homo sapiens | Alternative splicing Cell membrane Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Magnesium Manganese Membrane Metal-binding Phospholipid biosynthesis Phospholipid metabolism Reference proteome Transferase Transmembrane Transmembrane helix | MPDENIFLFV | MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK | phosphatidylinositol biosynthetic process endoplasmic reticulum membrane; Golgi apparatus; membrane; plasma membrane CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity metal ion binding Homo sapiens Alternative splicing Cell membrane Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Magnesium Mangan... |
apoptotic process cellular response to transforming growth factor beta stimulus negative regulation of cell population proliferation negative regulation of chaperone-mediated protein folding positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic proces... | cytoplasm; cytosol; extracellular exosome; nucleus | acetyltransferase activator activity beta-tubulin binding DNA binding heparin binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis Direct protein sequencing Phosphoprotein Reference proteome | MADEELEALR | MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY | apoptotic process cellular response to transforming growth factor beta stimulus negative regulation of cell population proliferation negative regulation of chaperone-mediated protein folding positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic proces... |
chromatin remodeling circadian regulation of gene expression DNA-templated transcription termination endothelial cell activation Golgi ribbon formation liver regeneration negative regulation of cell differentiation peptidyl-arginine methylation peptidyl-arginine N-methylation positive regulation of adenylate cyclase-in... | chromatin; cytoplasm; cytosol; Golgi apparatus; histone methyltransferase complex; methylosome; nucleoplasm; nucleus | E-box binding histone arginine N-methyltransferase activity histone H3 methyltransferase activity histone H4R3 methyltransferase activity histone methyltransferase activity identical protein binding methyl-CpG binding methyltransferase activity p53 binding protein heterodimerization activity protein-arginine N-methyltr... | Homo sapiens | 3D-structure Acetylation Alternative splicing Biological rhythms Chromatin regulator Chromosome Cytoplasm Direct protein sequencing Golgi apparatus Methyltransferase Nucleus Reference proteome Repressor S-adenosyl-L-methionine Transcription Transcription regulation Transferase | MAAMAVGGAG | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLE... | chromatin remodeling circadian regulation of gene expression DNA-templated transcription termination endothelial cell activation Golgi ribbon formation liver regeneration negative regulation of cell differentiation peptidyl-arginine methylation peptidyl-arginine N-methylation positive regulation of adenylate cyclase-in... |
androgen biosynthetic process androgen catabolic process brexanolone catabolic process retinol metabolic process steroid metabolic process | early endosome membrane; endoplasmic reticulum; intracellular membrane-bounded organelle | 5alpha-androstane-3beta,17beta-diol dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity catalytic activity electron transfer activity estradiol 17-beta-dehydrogenase activity NAD-retinol dehydrogenase activity oxidoreductase activity testosterone 17-beta-deh... | Homo sapiens | Endoplasmic reticulum Endosome Glycoprotein Lipid metabolism Membrane Microsome NAD Oxidoreductase Reference proteome Signal Steroid metabolism | MWLYLAAFVG | MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV | androgen biosynthetic process androgen catabolic process brexanolone catabolic process retinol metabolic process steroid metabolic process early endosome membrane; endoplasmic reticulum; intracellular membrane-bounded organelle 5alpha-androstane-3beta,17beta-diol dehydrogenase activity androstan-3-alpha,17-beta-diol de... |
activation of NF-kappaB-inducing kinase activity apoptotic process cell surface receptor signaling pathway cellular response to mechanical stimulus defense response to tumor cell extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to endoplasmic reticulum s... | cell surface; plasma membrane | signaling receptor activity TRAIL binding TRAIL receptor activity | Homo sapiens | 3D-structure Alternative splicing Apoptosis Direct protein sequencing Disulfide bond Glycoprotein Membrane Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix | MEQRGQNAPA | MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERS... | activation of NF-kappaB-inducing kinase activity apoptotic process cell surface receptor signaling pathway cellular response to mechanical stimulus defense response to tumor cell extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to endoplasmic reticulum s... |
chloride transmembrane transport gamma-aminobutyric acid signaling pathway signal transduction synaptic transmission, GABAergic | axon; chloride channel complex; dendrite; GABA-A receptor complex; GABA-ergic synapse; neuron projection; neuronal cell body; plasma membrane; postsynaptic membrane; synapse | chloride channel activity GABA-A receptor activity neurotransmitter receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | Homo sapiens | 3D-structure Cell membrane Chloride Chloride channel Disease variant Disulfide bond Epilepsy Glycoprotein Ion channel Ion transport Membrane Phosphoprotein Postsynaptic cell membrane Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MDAPARLLAP | MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVF... | chloride transmembrane transport gamma-aminobutyric acid signaling pathway signal transduction synaptic transmission, GABAergic axon; chloride channel complex; dendrite; GABA-A receptor complex; GABA-ergic synapse; neuron projection; neuronal cell body; plasma membrane; postsynaptic membrane; synapse chloride channel a... |
animal organ morphogenesis brain development embryonic pattern specification eye development negative regulation of myeloid cell differentiation negative regulation of transcription by RNA polymerase II pancreas development positive regulation of cardiac muscle myoblast proliferation positive regulation of cell populat... | chromatin; nucleus; perinuclear region of cytoplasm | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription facto... | Homo sapiens | 3D-structure Activator Alternative splicing Cytoplasm Developmental protein Disease variant DNA-binding Homeobox Intellectual disability Nucleus Reference proteome Transcription Transcription regulation | MAQRYDELPH | MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTI... | animal organ morphogenesis brain development embryonic pattern specification eye development negative regulation of myeloid cell differentiation negative regulation of transcription by RNA polymerase II pancreas development positive regulation of cardiac muscle myoblast proliferation positive regulation of cell populat... |
regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MAAPLEAQDQ | MAAPLEAQDQAPGEGEGLLIVKVEDSSWEQESAQHEDGRDSEACRQRFRQFCYGDVHGPHEAFSQLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQGWVREQHPGSGEEAVALVEDLQKQPVKAWRQDVPSEEAEPEAAGRGSQATGPPPTVGARRRPSVPQEQHSHSAQPPALLKEGRPGETTDTCFVSGVHGPVALGDIPFYFSREEWGTLDPAQRDLFWDIKRENSRNTTLGFGLKGQSEKSLLQEMVPVVPGQTGSDVTVSWSPEEAEAWESENRPRAALGPVVGARRGRPPTRRRQFRDLAAEKPHSCG... | regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Alternative splicing DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcripti... |
fucose metabolic process | cytoplasm; cytosol | catalytic activity fucose-1-phosphate guanylyltransferase activity GTP binding | Homo sapiens | Alternative splicing Cytoplasm GTP-binding Nucleotide-binding Nucleotidyltransferase Reference proteome Transferase | MRAVRRGLRE | MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCADDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRFLHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSCEIDAYGDFLQA... | fucose metabolic process cytoplasm; cytosol catalytic activity fucose-1-phosphate guanylyltransferase activity GTP binding Homo sapiens Alternative splicing Cytoplasm GTP-binding Nucleotide-binding Nucleotidyltransferase Reference proteome Transferase MRAVRRGLRE MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITA... |
bone resorption central nervous system development epithelial cell differentiation lipid metabolic process lysosomal protein catabolic process lysosome organization nervous system development neuromuscular process controlling balance peptide catabolic process protein catabolic process protein localization to chromosome... | extracellular exosome; Golgi apparatus; lysosomal lumen; lysosome; melanosome; membrane raft; recycling endosome | endopeptidase activity lysophosphatidic acid binding metal ion binding peptidase activity peptide binding serine-type endopeptidase activity serine-type peptidase activity sulfatide binding tripeptidyl-peptidase activity | Homo sapiens | 3D-structure Alternative splicing Autocatalytic cleavage Calcium Direct protein sequencing Disease variant Disulfide bond Epilepsy Glycoprotein Hydrolase Lysosome Metal-binding Neurodegeneration Neuronal ceroid lipofuscinosis Protease Reference proteome Serine protease Signal Spinocerebellar ataxia Zymogen | MGLQACLLGL | MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHV... | bone resorption central nervous system development epithelial cell differentiation lipid metabolic process lysosomal protein catabolic process lysosome organization nervous system development neuromuscular process controlling balance peptide catabolic process protein catabolic process protein localization to chromosome... |
dark adaptation dopamine receptor signaling pathway G protein-coupled receptor signaling pathway light adaption negative regulation of voltage-gated calcium channel activity positive regulation of GTPase activity signal transduction | cytoplasm; cytosol; GTPase activator complex; heterotrimeric G-protein complex; nucleus; presynapse | G-protein gamma-subunit binding GTPase activator activity GTPase activity protein-folding chaperone binding signaling receptor complex adaptor activity | Homo sapiens | 3D-structure Alternative splicing Disease variant Intellectual disability Membrane Reference proteome Repeat Transducer WD repeat | MCDQTFLVNV | MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS... | dark adaptation dopamine receptor signaling pathway G protein-coupled receptor signaling pathway light adaption negative regulation of voltage-gated calcium channel activity positive regulation of GTPase activity signal transduction cytoplasm; cytosol; GTPase activator complex; heterotrimeric G-protein complex; nucleus... |
attachment of mitotic spindle microtubules to kinetochore attachment of spindle microtubules to kinetochore cell division centrosome duplication chromosome segregation establishment of mitotic spindle orientation G2/MI transition of meiotic cell cycle kinetochore organization metaphase chromosome alignment mitotic cell... | centrosome; chromosome, centromeric region; cytosol; kinetochore; membrane; Ndc80 complex; nucleoplasm; nucleus; outer kinetochore | cyclin binding identical protein binding kinetochore adaptor activity microtubule binding | Homo sapiens | 3D-structure Acetylation Cell cycle Cell division Centromere Chromosome Coiled coil Kinetochore Mitosis Nucleus Phosphoprotein Reference proteome | MKRSSVSSGG | MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESH... | attachment of mitotic spindle microtubules to kinetochore attachment of spindle microtubules to kinetochore cell division centrosome duplication chromosome segregation establishment of mitotic spindle orientation G2/MI transition of meiotic cell cycle kinetochore organization metaphase chromosome alignment mitotic cell... |
microtubule-based movement | ciliary tip; cilium; cytosol; kinesin complex; microtubule | ATP binding ATP hydrolysis activity cytoskeletal motor activity microtubule binding microtubule motor activity | Homo sapiens | 3D-structure ATP-binding Coiled coil Cytoplasm Cytoskeleton Disease variant Microtubule Motor protein Nucleotide-binding Reference proteome | MASKTKASEA | MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDS... | microtubule-based movement ciliary tip; cilium; cytosol; kinesin complex; microtubule ATP binding ATP hydrolysis activity cytoskeletal motor activity microtubule binding microtubule motor activity Homo sapiens 3D-structure ATP-binding Coiled coil Cytoplasm Cytoskeleton Disease variant Microtubule Motor protein Nucleoti... |
protein import into nucleus | cytoplasm; nucleus | nuclear import signal receptor activity nuclear localization sequence binding small GTPase binding | Homo sapiens | Acetylation Alternative splicing Cytoplasm Disease variant Intellectual disability Nucleus Protein transport Reference proteome Repeat Transport | MDWQPDEQGL | MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDV... | protein import into nucleus cytoplasm; nucleus nuclear import signal receptor activity nuclear localization sequence binding small GTPase binding Homo sapiens Acetylation Alternative splicing Cytoplasm Disease variant Intellectual disability Nucleus Protein transport Reference proteome Repeat Transport MDWQPDEQGL MDWQP... |
chloride transmembrane transport cholesterol metabolic process cytolysis by host of symbiont cells innate immune response lipid transport lipoprotein metabolic process | blood microparticle; endoplasmic reticulum lumen; extracellular region; extracellular space; high-density lipoprotein particle; membrane; very-low-density lipoprotein particle | chloride channel activity lipid binding | Homo sapiens | 3D-structure Alternative splicing Cholesterol metabolism Direct protein sequencing Disease variant Glycoprotein HDL Lipid metabolism Lipid transport Phosphoprotein Reference proteome Secreted Signal Steroid metabolism Sterol metabolism Transport | MEGAALLRVS | MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVER... | chloride transmembrane transport cholesterol metabolic process cytolysis by host of symbiont cells innate immune response lipid transport lipoprotein metabolic process blood microparticle; endoplasmic reticulum lumen; extracellular region; extracellular space; high-density lipoprotein particle; membrane; very-low-densi... |
glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, enzymatic modification | Golgi lumen | -glucosamine 3-sulfotransferase 1 activity sulfotransferase activity | Homo sapiens | 3D-structure Disulfide bond Glycoprotein Golgi apparatus Reference proteome Signal Transferase | MAALLLGAVL | MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH | glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, enzymatic modification Golgi lumen -glucosamine 3-sulfotransferase 1 activity sulfotransferase activity Homo sapiens 3D-structure Disulfide bond Glycoprotein Golgi apparatus Reference proteome Signal Transferase MAALLLGAVL MAALLLG... |
adaptive immune response innate immune response leukocyte activation involved in immune response positive regulation of innate immune response positive regulation of natural killer cell mediated immunity | cytosol | protein-macromolecule adaptor activity | Homo sapiens | 3D-structure Adaptive immunity Alternative splicing Immunity Innate immunity Phosphoprotein Reference proteome SH2 domain | MDLPYYHGRL | MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP | adaptive immune response innate immune response leukocyte activation involved in immune response positive regulation of innate immune response positive regulation of natural killer cell mediated immunity cytosol protein-macromolecule adaptor activity Homo sapiens 3D-structure Adaptive immunity Alternative splicing Immu... |
positive regulation of apoptotic process TRAIL-activated apoptotic signaling pathway | cell surface; plasma membrane; side of membrane | TRAIL binding transmembrane signaling receptor activity | Homo sapiens | Apoptosis Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Receptor Reference proteome Repeat Signal | MARIPKTLKF | MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV | positive regulation of apoptotic process TRAIL-activated apoptotic signaling pathway cell surface; plasma membrane; side of membrane TRAIL binding transmembrane signaling receptor activity Homo sapiens Apoptosis Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Receptor... |
G protein-coupled receptor signaling pathway sensory perception of chemical stimulus signal transduction | plasma membrane | G protein-coupled receptor activity trace-amine receptor activity trimethylamine receptor activity | Homo sapiens | Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MRAVFIQGAE | MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQWFRKALKLTL... | G protein-coupled receptor signaling pathway sensory perception of chemical stimulus signal transduction plasma membrane G protein-coupled receptor activity trace-amine receptor activity trimethylamine receptor activity Homo sapiens Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor ... |
actin cytoskeleton organization cellular response to leukemia inhibitory factor Ras protein signal transduction | plasma membrane | G protein activity GDP binding GTP binding GTP-dependent protein binding GTPase activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disease variant GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MATSAVPSDN | MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL | actin cytoskeleton organization cellular response to leukemia inhibitory factor Ras protein signal transduction plasma membrane G protein activity GDP binding GTP binding GTP-dependent protein binding GTPase activity Homo sapiens 3D-structure Alternative splicing Cell membrane Disease variant GTP-binding Hydrolase Lipo... |
chemical synaptic transmission exocytosis insulin secretion regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane regulation of exocytosis regulation of neurotransmitter secretion regulation of synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle exocytosis | calyx of Held; cytosol; glutamatergic synapse; perikaryon; postsynapse; Schaffer collateral - CA1 synapse; SNARE complex; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; terminal bouton | neurotransmitter transmembrane transporter activity SNARE binding syntaxin binding | Homo sapiens | 3D-structure Cell projection Coiled coil Cytoplasm Disease variant Epilepsy Exocytosis Neurotransmitter transport Reference proteome Synapse Transport | MEFVMKQALG | MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK | chemical synaptic transmission exocytosis insulin secretion regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane regulation of exocytosis regulation of neurotransmitter secretion regulation of synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle exocytosis calyx... |
dopaminergic neuron differentiation locus ceruleus development midbrain development noradrenergic neuron differentiation oculomotor nerve formation positive regulation of transcription by RNA polymerase II regulation of respiratory gaseous exchange regulation of transcription by RNA polymerase II somatic motor neuron d... | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Disease variant DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MDYSYLNSYD | MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF | dopaminergic neuron differentiation locus ceruleus development midbrain development noradrenergic neuron differentiation oculomotor nerve formation positive regulation of transcription by RNA polymerase II regulation of respiratory gaseous exchange regulation of transcription by RNA polymerase II somatic motor neuron d... |
digestion proteolysis | cytoplasm | calcium ion binding calcium-dependent cysteine-type endopeptidase activity | Homo sapiens | 3D-structure Alternative splicing Calcium Hydrolase Metal-binding Protease Reference proteome Repeat Thiol protease | MPYLYRAPGP | MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMA... | digestion proteolysis cytoplasm calcium ion binding calcium-dependent cysteine-type endopeptidase activity Homo sapiens 3D-structure Alternative splicing Calcium Hydrolase Metal-binding Protease Reference proteome Repeat Thiol protease MPYLYRAPGP MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEI... |
protein-containing complex assembly | focal adhesion; plasma membrane; vesicle | antigen binding integrin binding | Homo sapiens | Glycoprotein Membrane Reference proteome Transmembrane Transmembrane helix | MARACLQAVK | MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA | protein-containing complex assembly focal adhesion; plasma membrane; vesicle antigen binding integrin binding Homo sapiens Glycoprotein Membrane Reference proteome Transmembrane Transmembrane helix MARACLQAVK MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKI... |
proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; postsynapse; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex | identical protein binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Glycoprotein Host-virus interaction Nucleus Phosphoprotein Proteasome Reference proteome | MSYDRAITVF | MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS | proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; postsynapse; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex identical protein binding Homo sapiens 3D-stru... |
post-Golgi vesicle-mediated transport protein transport | extracellular exosome; intracellular membrane-bounded organelle; recycling endosome membrane; trans-Golgi network membrane | ubiquitin protein ligase binding | Homo sapiens | Alternative splicing Isopeptide bond Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation | MAQSRDGGNP | MAQSRDGGNPFAEPSELDNPFQDPAVIQHRPSRQYATLDVYNPFETREPPPAYEPPAPAPLPPPSAPSLQPSRKLSPTEPKNYGSYSTQASAAAATAELLKKQEELNRKAEELDRRERELQHAALGGTATRQNNWPPLPSFCPVQPCFFQDISMEIPQEFQKTVSTMYYLWMCSTLALLLNFLACLASFCVETNNGAGFGLSILWVLLFTPCSFVCWYRPMYKAFRSDSSFNFFVFFFIFFVQDVLFVLQAIGIPGWGFSGWISALVVPKGNTAVSVLMLLVALLFTGIAVLGIVMLKRIHSLYRRTGASFQKAQQEFAA... | post-Golgi vesicle-mediated transport protein transport extracellular exosome; intracellular membrane-bounded organelle; recycling endosome membrane; trans-Golgi network membrane ubiquitin protein ligase binding Homo sapiens Alternative splicing Isopeptide bond Membrane Phosphoprotein Protein transport Reference proteo... |
detection of stimulus involved in sensory perception protein dephosphorylation | cytosol; nucleus | calcium ion binding iron ion binding manganese ion binding myosin phosphatase activity protein serine/threonine phosphatase activity | Homo sapiens | Alternative splicing Calcium Hydrolase Magnesium Manganese Metal-binding Protein phosphatase Reference proteome Repeat | MGCSSSSTKT | MGCSSSSTKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHD... | detection of stimulus involved in sensory perception protein dephosphorylation cytosol; nucleus calcium ion binding iron ion binding manganese ion binding myosin phosphatase activity protein serine/threonine phosphatase activity Homo sapiens Alternative splicing Calcium Hydrolase Magnesium Manganese Metal-binding Prote... |
detection of stimulus involved in sensory perception negative regulation of MAPK cascade negative regulation of peptidyl-threonine phosphorylation protein dephosphorylation regulation of JUN kinase activity regulation of MAP kinase activity visual perception | cytosol; nucleus; photoreceptor inner segment; photoreceptor outer segment | calcium ion binding Hsp70 protein binding Hsp90 protein binding iron ion binding manganese ion binding mitogen-activated protein kinase kinase kinase binding myosin phosphatase activity protein serine/threonine phosphatase activity | Homo sapiens | Alternative splicing Calcium Cell projection Cilium Cytoplasm Hydrolase Manganese Metal-binding Protein phosphatase Reference proteome Repeat Sensory transduction Vision | MGSGTSTQHH | MGSGTSTQHHFAFQNAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVKLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKT... | detection of stimulus involved in sensory perception negative regulation of MAPK cascade negative regulation of peptidyl-threonine phosphorylation protein dephosphorylation regulation of JUN kinase activity regulation of MAP kinase activity visual perception cytosol; nucleus; photoreceptor inner segment; photoreceptor ... |
2-oxobutyrate catabolic process 2-oxoglutarate metabolic process fatty acid alpha-oxidation isoprenoid metabolic process methyl-branched fatty acid metabolic process | 9+0 non-motile cilium; cytosol; peroxisomal matrix; peroxisome | carboxylic acid binding ferrous iron binding L-ascorbic acid binding phytanoyl-CoA dioxygenase activity | Homo sapiens | 3D-structure Alternative splicing Cataract Deafness Dioxygenase Disease variant Ichthyosis Iron Metal-binding Oxidoreductase Peroxisome Peroxisome biogenesis disorder Phosphoprotein Reference proteome Retinitis pigmentosa Transit peptide Vitamin C | MEQLRAAARL | MEQLRAAARLQIVLGHLGRPSAGAVVAHPTSGTISSASFHPQQFQYTLDNNVLTLEQRKFYEENGFLVIKNLVPDADIQRFRNEFEKICRKEVKPLGLTVMRDVTISKSEYAPSEKMITKVQDFQEDKELFRYCTLPEILKYVECFTGPNIMAMHTMLINKPPDSGKKTSRHPLHQDLHYFPFRPSDLIVCAWTAMEHISRNNGCLVVLPGTHKGSLKPHDYPKWEGGVNKMFHGIQDYEENKARVHLVMEKGDTVFFHPLLIHGSGQNKTQGFRKAISCHFASADCHYIDVKGTSQENIEKEVVGIAHKFFGAENSVNL... | 2-oxobutyrate catabolic process 2-oxoglutarate metabolic process fatty acid alpha-oxidation isoprenoid metabolic process methyl-branched fatty acid metabolic process 9+0 non-motile cilium; cytosol; peroxisomal matrix; peroxisome carboxylic acid binding ferrous iron binding L-ascorbic acid binding phytanoyl-CoA dioxygen... |
adaptive immune response B cell homeostasis cell surface receptor signaling pathway hematopoietic progenitor cell differentiation negative regulation of B cell proliferation | plasma membrane | signaling receptor activity | Homo sapiens | 3D-structure Adaptive immunity Alternative splicing Disease variant Disulfide bond Glycoprotein Immunity Membrane Receptor Reference proteome Repeat Signal-anchor Transmembrane Transmembrane helix | MSGLGRSRRG | MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA | adaptive immune response B cell homeostasis cell surface receptor signaling pathway hematopoietic progenitor cell differentiation negative regulation of B cell proliferation plasma membrane signaling receptor activity Homo sapiens 3D-structure Adaptive immunity Alternative splicing Disease variant Disulfide bond Glycop... |
G protein-coupled receptor signaling pathway glucose homeostasis insulin secretion ion channel modulating, G protein-coupled receptor signaling pathway ligand-gated ion channel signaling pathway negative regulation of interleukin-1 beta production phospholipase C-activating G protein-coupled receptor signaling pathway ... | plasma membrane | bioactive lipid receptor activity G protein-coupled receptor activity lipid binding | Homo sapiens | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Lipid-binding Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MDLPPQLSFG | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK | G protein-coupled receptor signaling pathway glucose homeostasis insulin secretion ion channel modulating, G protein-coupled receptor signaling pathway ligand-gated ion channel signaling pathway negative regulation of interleukin-1 beta production phospholipase C-activating G protein-coupled receptor signaling pathway ... |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to fatty acid G protein-coupled receptor signaling pathway inflammatory response mucosal immune response negative regulation of blood pressure positive regulation of acute inflammatory response to non-antigenic stimulus positive... | plasma membrane | G protein-coupled receptor activity lipid binding | Homo sapiens | Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Immunity Inflammatory response Lipid-binding Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MDTGPDQSYF | MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRA... | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to fatty acid G protein-coupled receptor signaling pathway inflammatory response mucosal immune response negative regulation of blood pressure positive regulation of acute inflammatory response to non-antigenic stimulus positive... |
activation of innate immune response AIM2 inflammasome complex assembly brain development cellular response to interferon-beta cellular response to xenobiotic stimulus defense response to virus DNA damage response immune response inflammatory response innate immune response negative regulation of NF-kappaB transcriptio... | AIM2 inflammasome complex; cytoplasm; cytosol; mitochondrion; nucleoplasm; site of double-strand break | cysteine-type endopeptidase activator activity double-stranded DNA binding identical protein binding pattern recognition receptor activity signaling adaptor activity | Homo sapiens | 3D-structure Cytoplasm DNA damage DNA-binding Immunity Inflammasome Inflammatory response Innate immunity Nucleus Reference proteome Tumor suppressor | MESKYKEILL | MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKN... | activation of innate immune response AIM2 inflammasome complex assembly brain development cellular response to interferon-beta cellular response to xenobiotic stimulus defense response to virus DNA damage response immune response inflammatory response innate immune response negative regulation of NF-kappaB transcriptio... |
response to toxic substance response to zinc ion zinc export across plasma membrane zinc ion import into lysosome zinc ion transmembrane transport | cytoplasm; endosome membrane; late endosome; late endosome membrane; lysosomal membrane; plasma membrane | antiporter activity metal ion binding zinc ion transmembrane transporter activity | Homo sapiens | Antiport Endosome Ion transport Lysosome Membrane Metal-binding Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc transport | MAGSGAWKRL | MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTT... | response to toxic substance response to zinc ion zinc export across plasma membrane zinc ion import into lysosome zinc ion transmembrane transport cytoplasm; endosome membrane; late endosome; late endosome membrane; lysosomal membrane; plasma membrane antiporter activity metal ion binding zinc ion transmembrane transpo... |
DNA repair negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of metabolic process regulation of transcription by RNA polymerase II | chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific heme binding ligand-activated transcription factor activity RN... | Homo sapiens | 3D-structure Activator DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MSLSENSVFA | MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGL... | DNA repair negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of metabolic process regulation of transcription by RNA polymerase II chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex DNA-binding transcription... |
amino acid catabolic process branched-chain amino acid catabolic process lipid biosynthetic process negative regulation of cellular amino acid metabolic process phosphorylation regulation of glucose metabolic process | mitochondrial alpha-ketoglutarate dehydrogenase complex; mitochondrial matrix; mitochondrion | kinase activity ATP binding kinase activity protein serine kinase activity protein serine/threonine kinase activity protein serine/threonine phosphatase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Autism Autism spectrum disorder Disease variant Epilepsy Intellectual disability Kinase Mitochondrion Nucleotide-binding Phosphoprotein Reference proteome Transferase Transit peptide | MILASVLRSG | MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGI... | amino acid catabolic process branched-chain amino acid catabolic process lipid biosynthetic process negative regulation of cellular amino acid metabolic process phosphorylation regulation of glucose metabolic process mitochondrial alpha-ketoglutarate dehydrogenase complex; mitochondrial matrix; mitochondrion kinase ac... |
antiviral innate immune response defense response to virus negative regulation of apoptotic process negative regulation of cell population proliferation response to virus | cytoplasm; cytosol; mitochondrion | identical protein binding | Homo sapiens | 3D-structure Antiviral defense Cytoplasm Immunity Innate immunity Mitochondrion Phosphoprotein Reference proteome Repeat TPR repeat | MSEVTKNSLE | MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNK... | antiviral innate immune response defense response to virus negative regulation of apoptotic process negative regulation of cell population proliferation response to virus cytoplasm; cytosol; mitochondrion identical protein binding Homo sapiens 3D-structure Antiviral defense Cytoplasm Immunity Innate immunity Mitochondr... |
arachidonic acid metabolic process leukotriene biosynthetic process lipid metabolic process prostanoid metabolic process | endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; mitochondrial outer membrane; nuclear envelope | glutathione peroxidase activity glutathione transferase activity identical protein binding leukotriene-C4 synthase activity | Homo sapiens | Lipid metabolism Lipoprotein Lyase Membrane Mitochondrion Mitochondrion outer membrane Oxidoreductase Palmitate Reference proteome Transferase Transmembrane Transmembrane helix | MAVLSKEYGF | MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH | arachidonic acid metabolic process leukotriene biosynthetic process lipid metabolic process prostanoid metabolic process endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; mitochondrial outer membrane; nuclear envelope glutathione peroxidase activity glutathione t... |
cell cycle regulation of G1/S transition of mitotic cell cycle | lysosomal membrane; plasma membrane | arginine binding | Homo sapiens | Cell cycle Cell membrane Glycoprotein Lysosome Membrane Reference proteome Transmembrane Transmembrane helix | MCTGKCARCV | MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH | cell cycle regulation of G1/S transition of mitotic cell cycle lysosomal membrane; plasma membrane arginine binding Homo sapiens Cell cycle Cell membrane Glycoprotein Lysosome Membrane Reference proteome Transmembrane Transmembrane helix MCTGKCARCV MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAG... |
cell development cranial skeletal system development immune system process keratinocyte differentiation keratinocyte proliferation limb development mammary gland epithelial cell differentiation negative regulation of cell population proliferation negative regulation of keratinocyte proliferation negative regulation of ... | chromatin; cytoplasm; cytosol; extracellular exosome; nucleus | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific doubl... | Homo sapiens | Alternative splicing Cytoplasm Differentiation Disease variant DNA-binding Nucleus Reference proteome Transcription Transcription regulation Ubl conjugation | MALHPRRVRL | MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCK... | cell development cranial skeletal system development immune system process keratinocyte differentiation keratinocyte proliferation limb development mammary gland epithelial cell differentiation negative regulation of cell population proliferation negative regulation of keratinocyte proliferation negative regulation of ... |
apoptotic process cellular response to peptide negative regulation of cell population proliferation negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process regulation of G1/S transition of mitotic cell cycle regulation of transcription by RNA polymerase II | chromatin; cytosol; focal adhesion; nuclear body; nucleoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding | Homo sapiens | Activator Alternative splicing Apoptosis Diabetes mellitus Disease variant DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Zinc Zinc-finger | MHTPDFAGPD | MHTPDFAGPDDARAVDIMDICESILERKRHDSERSTCSILEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQ... | apoptotic process cellular response to peptide negative regulation of cell population proliferation negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process regulation of G1/S transition of mitotic cell cycle regulation of transcription by RNA polymerase II chromatin; cytosol; ... |
canonical Wnt signaling pathway cell fate commitment cellular response to retinoic acid cornea development in camera-type eye embryonic skeletal joint development iris morphogenesis negative regulation of cell population proliferation negative regulation of chondrocyte differentiation neuron differentiation | extracellular region; extracellular space | cytokine activity frizzled binding receptor ligand activity | Homo sapiens | Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Reference proteome Secreted Signal Wnt signaling pathway | MLDGSPLARW | MLDGSPLARWLAAAFGLTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAAAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAGRRCHREKNCE... | canonical Wnt signaling pathway cell fate commitment cellular response to retinoic acid cornea development in camera-type eye embryonic skeletal joint development iris morphogenesis negative regulation of cell population proliferation negative regulation of chondrocyte differentiation neuron differentiation extracellul... |
activation of GTPase activity negative regulation of cell population proliferation negative regulation of protein localization to cell surface negative regulation of Wnt signaling pathway Rho protein signal transduction Wnt signaling pathway | actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; fibrillar center; intracellular membrane-bounded organelle; plasma membrane | beta-catenin binding | Homo sapiens | 3D-structure Acetylation Cell membrane Cytoplasm Membrane Nucleus Phosphoprotein Reference proteome Wnt signaling pathway | MSYIPGQPVT | MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS | activation of GTPase activity negative regulation of cell population proliferation negative regulation of protein localization to cell surface negative regulation of Wnt signaling pathway Rho protein signal transduction Wnt signaling pathway actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; fibrillar cente... |
cellular response to interleukin-7 chemical synaptic transmission endothelial cell migration G protein-coupled receptor signaling pathway glutamate secretion negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of cytokinesis positive regulation of melanin biosynthetic pr... | cell cortex; cytoplasm; cytoplasmic vesicle; cytosol; dendritic shaft; dendritic spine; extracellular exosome; glutamatergic synapse; membrane; Schaffer collateral - CA1 synapse; synaptic vesicle; vesicle membrane | actin binding cadherin binding identical protein binding myosin binding signaling receptor binding | Homo sapiens | Alternative splicing Congenital muscular dystrophy Cytoplasm Dystroglycanopathy Membrane Phosphoprotein Reference proteome | MPLGLGRRKK | MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFD... | cellular response to interleukin-7 chemical synaptic transmission endothelial cell migration G protein-coupled receptor signaling pathway glutamate secretion negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of cytokinesis positive regulation of melanin biosynthetic pr... |
exocytosis inner ear development maintenance of epithelial cell apical/basal polarity neurotransmitter secretion protein localization to basolateral plasma membrane protein transport protein-containing complex assembly synaptic vesicle transport | basolateral plasma membrane; bicellular tight junction; cell-cell junction; extracellular exosome; MPP7-DLG1-LIN7 complex; plasma membrane; postsynaptic density membrane; presynapse; synapse | L27 domain binding | Homo sapiens | Cell junction Cell membrane Exocytosis Membrane Postsynaptic cell membrane Protein transport Reference proteome Synapse Tight junction Transport | MLKPSVTSAP | MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS | exocytosis inner ear development maintenance of epithelial cell apical/basal polarity neurotransmitter secretion protein localization to basolateral plasma membrane protein transport protein-containing complex assembly synaptic vesicle transport basolateral plasma membrane; bicellular tight junction; cell-cell junction... |
intracellular protein transport protein import into mitochondrial matrix protein targeting to mitochondrion | mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; TIM23 mitochondrial import inner membrane translocase complex | protein transmembrane transporter activity | Homo sapiens | Membrane Mitochondrion Mitochondrion inner membrane Protein transport Reference proteome Translocation Transmembrane Transmembrane helix Transport | MEGGGGSGNK | MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL | intracellular protein transport protein import into mitochondrial matrix protein targeting to mitochondrion mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; TIM23 mitochondrial import inner membrane translocase complex protein transmembrane transporter activity Homo sapiens Membrane Mitoc... |
actin cytoskeleton organization actin filament bundle assembly anatomical structure morphogenesis cell migration establishment or maintenance of cell polarity eye photoreceptor cell development visual perception | actin cytoskeleton; cytoplasm; stereocilium | actin binding actin filament binding protein-macromolecule adaptor activity | Homo sapiens | Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Reference proteome Retinitis pigmentosa | MPTNGLHQVL | MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGQGTAVLLRSSHLGRYLSAEEDGRVACEAEQPGRDCRFLVLPQPDGRWVLRSEPHGRFFGGTEDQLSCFATAVSPAELWTVHLAIHPQAHLLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSRRYCLKSCDSRYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGG... | actin cytoskeleton organization actin filament bundle assembly anatomical structure morphogenesis cell migration establishment or maintenance of cell polarity eye photoreceptor cell development visual perception actin cytoskeleton; cytoplasm; stereocilium actin binding actin filament binding protein-macromolecule adapt... |
chromosome organization internal protein amino acid acetylation nucleosome assembly subtelomeric heterochromatin formation | chromatin; chromosome, telomeric region; mitochondrion; nuclear matrix; nucleoplasm; nucleus; protein-containing complex | histone acetyltransferase activity histone binding histone H4 acetyltransferase activity histone H4K12 acetyltransferase activity | Homo sapiens | 3D-structure Acetylation Acyltransferase Alternative splicing Cytoplasm Mitochondrion Nucleus Phosphoprotein Reference proteome Transferase | MAGFGAMEKF | MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMVIEAQQK... | chromosome organization internal protein amino acid acetylation nucleosome assembly subtelomeric heterochromatin formation chromatin; chromosome, telomeric region; mitochondrion; nuclear matrix; nucleoplasm; nucleus; protein-containing complex histone acetyltransferase activity histone binding histone H4 acetyltransfer... |
cell recognition immune response immune response-activating cell surface receptor signaling pathway inflammatory response natural killer cell activation positive regulation of natural killer cell mediated cytotoxicity | plasma membrane | identical protein binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Receptor Reference proteome Signal Transmembrane Transmembrane helix | MAWMLLLILI | MAWMLLLILIMVHPGSCALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRDVRGHDASIYVCRVEVLGLGVGTGNGTRLVVEKEHPQLGAGTVLLLRAGFYAVSFLSVAVGSTVYYQGKCLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG | cell recognition immune response immune response-activating cell surface receptor signaling pathway inflammatory response natural killer cell activation positive regulation of natural killer cell mediated cytotoxicity plasma membrane identical protein binding Homo sapiens 3D-structure Alternative splicing Cell membrane... |
innate immune response ISG15-protein conjugation protein modification process protein polyubiquitination ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; nucleoplasm; nucleus; ubiquitin ligase complex | ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin-protein transferase activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Reference proteome Transferase Ubl conjugation Ubl conjugation pathway | MMASMRVVKE | MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS | innate immune response ISG15-protein conjugation protein modification process protein polyubiquitination ubiquitin-dependent protein catabolic process cytoplasm; cytosol; nucleoplasm; nucleus; ubiquitin ligase complex ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity ubiquitin protein l... |
calcium ion import cell adhesion establishment of localization in cell negative regulation of cell-matrix adhesion negative regulation of cellular response to growth factor stimulus negative regulation of keratinocyte proliferation negative regulation of wound healing phosphorylation positive regulation of calcium ion ... | actin cytoskeleton; basement membrane; basolateral plasma membrane; cell-cell junction; ciliary membrane; cytoplasm; cytosol; focal adhesion; nuclear lamina; nuclear matrix; nucleolus; plasma membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; vesicle | ATP binding calmodulin binding guanylate kinase activity neurexin family protein binding protein serine kinase activity protein serine/threonine kinase activity signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Calmodulin-binding Cell membrane Cytoplasm Disease variant Intellectual disability Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase SH3 domain Transferase | MADDDVLFED | MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSF... | calcium ion import cell adhesion establishment of localization in cell negative regulation of cell-matrix adhesion negative regulation of cellular response to growth factor stimulus negative regulation of keratinocyte proliferation negative regulation of wound healing phosphorylation positive regulation of calcium ion ... |
cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis phosphatidic acid biosynthetic process phospholipid catabolic process regulation of vesicle-mediated transport small GTPase mediated signal transduction synaptic vesicle recycling | endoplasmic reticulum membrane; intracellular membrane-bounded organelle; plasma membrane; presynapse | N-acylphosphatidylethanolamine-specific phospholipase D activity phosphatidylinositol binding phospholipase D activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Hydrolase Lipid degradation Lipid metabolism Lipoprotein Membrane Phosphoprotein Reference proteome Repeat | MTATPESLFP | MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQL... | cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis phosphatidic acid biosynthetic process phospholipid catabolic process regulation of vesicle-mediated transport small GTPase mediated signal transduction synaptic vesicle recycling endoplasmic reticulum membrane; intracellular membran... |
cellular response to heat negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; cytosol; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequ... | Homo sapiens | Activator Alternative splicing DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation | MTLDHQIINP | MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDP... | cellular response to heat negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; cytosol; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding tra... |
regulation of cell shape | apical part of cell; brush border; cell cortex; cytoplasm; cytosol; extracellular exosome; myofibril; myosin II complex; stress fiber; Z disc | calcium ion binding myosin heavy chain binding | Homo sapiens | Calcium Metal-binding Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat | MSSKKAKTKT | MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD | regulation of cell shape apical part of cell; brush border; cell cortex; cytoplasm; cytosol; extracellular exosome; myofibril; myosin II complex; stress fiber; Z disc calcium ion binding myosin heavy chain binding Homo sapiens Calcium Metal-binding Motor protein Muscle protein Myosin Phosphoprotein Reference proteome R... |
cardiac muscle contraction cellular response to caffeine detection of calcium ion intracellular calcium ion homeostasis negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport negative regulation of ryanodine-sensitive calcium-release channel activity prote... | calcium channel complex; cytoplasm; junctional sarcoplasmic reticulum membrane; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; sarcoplasmic reticulum membrane; Z disc | calcium ion binding calcium ion sequestering activity calcium-dependent protein binding ion binding protein homodimerization activity | Homo sapiens | 3D-structure Alternative splicing Calcium Disease variant Glycoprotein Metal-binding Muscle protein Phosphoprotein Reference proteome Sarcoplasmic reticulum Signal | MKRTHLFIVG | MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPVSSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELVEFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEK... | cardiac muscle contraction cellular response to caffeine detection of calcium ion intracellular calcium ion homeostasis negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport negative regulation of ryanodine-sensitive calcium-release channel activity prote... |
chemotaxis skeletal system development | cytoplasm; extracellular space | identical protein binding metal ion binding | Homo sapiens | 3D-structure Chemotaxis Cytoplasm Disulfide bond Metal-binding Reference proteome Secreted Signal Zinc | MFSTKALLLA | MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQYSAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGFCVKMFYIKPIKYKGPIKKGEKLGTLLPLQKVYPGIQSHVHIENCDSSDPTAYL | chemotaxis skeletal system development cytoplasm; extracellular space identical protein binding metal ion binding Homo sapiens 3D-structure Chemotaxis Cytoplasm Disulfide bond Metal-binding Reference proteome Secreted Signal Zinc MFSTKALLLA MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQYSAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEK... |
endocytic recycling endosomal transport macroautophagy membrane fission membrane invagination multivesicular body assembly negative regulation of angiogenesis negative regulation of cell population proliferation negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of rece... | cytosol; early endosome; early endosome membrane; endosome; ESCRT-0 complex; extracellular exosome; lysosome; multivesicular body membrane; phagocytic vesicle lumen | metal ion binding phosphatidylinositol binding protein domain specific binding ubiquitin binding ubiquitin-like protein ligase binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Endosome Membrane Metal-binding Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation Zinc Zinc-finger | MGRGSGTFER | MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAE... | endocytic recycling endosomal transport macroautophagy membrane fission membrane invagination multivesicular body assembly negative regulation of angiogenesis negative regulation of cell population proliferation negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of rece... |
cell differentiation Golgi organization intracellular protein transport melanosome organization mitochondrion organization modulation by host of viral process negative regulation of neuron projection development positive regulation of intracellular protein transport positive regulation of receptor recycling positive re... | cis-Golgi network; cytoplasm; cytoskeleton; cytosol; early endosome; endomembrane system; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; intracellular vesicle; melanosome; mitochondrion; perinuclear region of cytoplasm; plasma membrane; recycling endosome; trans-Golgi network; vacuole... | dynein complex binding GDP binding GTP binding GTPase activity kinesin binding small GTPase binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cytoplasm Cytoskeleton Differentiation Golgi apparatus GTP-binding Lipoprotein Membrane Nucleotide-binding Phosphoprotein Prenylation Protein transport Reference proteome Transport Vacuole | MGSRDHLFKV | MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC | cell differentiation Golgi organization intracellular protein transport melanosome organization mitochondrion organization modulation by host of viral process negative regulation of neuron projection development positive regulation of intracellular protein transport positive regulation of receptor recycling positive re... |
binding of sperm to zona pellucida protein folding protein-containing complex assembly single fertilization ubiquitin-dependent ERAD pathway | endoplasmic reticulum; endoplasmic reticulum membrane | calcium ion binding protein folding chaperone unfolded protein binding | Homo sapiens | Acetylation Alternative splicing Calcium Chaperone Disulfide bond Endoplasmic reticulum Membrane Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix | MHFQAFWLCL | MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEVYFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPK... | binding of sperm to zona pellucida protein folding protein-containing complex assembly single fertilization ubiquitin-dependent ERAD pathway endoplasmic reticulum; endoplasmic reticulum membrane calcium ion binding protein folding chaperone unfolded protein binding Homo sapiens Acetylation Alternative splicing Calcium ... |
bile acid biosynthetic process fatty acid alpha-oxidation fatty acid beta-oxidation fatty-acyl-CoA biosynthetic process long-chain fatty acid import into cell long-chain fatty acid metabolic process methyl-branched fatty acid metabolic process very long-chain fatty acid catabolic process | cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; peroxisomal membrane; plasma membrane; specific granule membrane | arachidonate-CoA ligase activity ATP binding cholate-CoA ligase activity enzyme binding fatty acid transmembrane transporter activity long-chain fatty acid transporter activity long-chain fatty acid-CoA ligase activity oleate transmembrane transporter activity phytanate-CoA ligase activity pristanate-CoA ligase activit... | Homo sapiens | Acetylation Alternative splicing ATP-binding Cell membrane Endoplasmic reticulum Fatty acid metabolism Ligase Lipid metabolism Lipid transport Membrane Microsome Nucleotide-binding Peroxisome Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MLSAIYTVLA | MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFLEKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLC... | bile acid biosynthetic process fatty acid alpha-oxidation fatty acid beta-oxidation fatty-acyl-CoA biosynthetic process long-chain fatty acid import into cell long-chain fatty acid metabolic process methyl-branched fatty acid metabolic process very long-chain fatty acid catabolic process cytosol; endoplasmic reticulum;... |
negative regulation of protein catabolic process positive regulation of polyamine transmembrane transport putrescine biosynthetic process from ornithine | cytoplasm; cytosol; nucleus | ornithine decarboxylase activator activity ornithine decarboxylase activity | Homo sapiens | 3D-structure Nucleus Polyamine biosynthesis Reference proteome Ubl conjugation | MKGFIDDANY | MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGV... | negative regulation of protein catabolic process positive regulation of polyamine transmembrane transport putrescine biosynthetic process from ornithine cytoplasm; cytosol; nucleus ornithine decarboxylase activator activity ornithine decarboxylase activity Homo sapiens 3D-structure Nucleus Polyamine biosynthesis Refere... |
negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific... | Homo sapiens | DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MASGPGSQER | MASGPGSQEREGLLIVKLEEDCAWSQELPPPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLL... | negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-sp... |
regulation of gene expression RNA processing | cytosol; nucleoplasm; nucleus; spliceosomal complex | DNA binding double-stranded DNA binding poly(A) binding poly(G) binding RNA binding single-stranded DNA binding | Homo sapiens | 3D-structure Acetylation Activator Alternative splicing Cytoplasm Direct protein sequencing Disease variant DNA-binding Isopeptide bond Limb-girdle muscular dystrophy Methylation Nucleus Phosphoprotein Reference proteome Repeat Repressor RNA-binding Transcription Transcription regulation Ubl conjugation | MEVPPRLSHV | MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQ... | regulation of gene expression RNA processing cytosol; nucleoplasm; nucleus; spliceosomal complex DNA binding double-stranded DNA binding poly(A) binding poly(G) binding RNA binding single-stranded DNA binding Homo sapiens 3D-structure Acetylation Activator Alternative splicing Cytoplasm Direct protein sequencing Diseas... |
phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process phosphorylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | cytosol; endomembrane system; plasma membrane; uropod | 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-5-kinase activity ATP binding phosphatidylinositol kinase activity | Homo sapiens | Alternative splicing ATP-binding Cell membrane Cytoplasm Kinase Lipid metabolism Membrane Nucleotide-binding Phosphoprotein Reference proteome Transferase | MSSAAENGEA | MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDG... | phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process phosphorylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction cytosol; endomembrane system; plasma membrane; uropod 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol... |
neurotransmitter secretion regulation of synaptic transmission, GABAergic synaptic vesicle clustering | extrinsic component of synaptic vesicle membrane; glutamatergic synapse; postsynaptic density; synaptic vesicle; synaptic vesicle membrane | ATP binding | Homo sapiens | 3D-structure ATP-binding Calcium Cytoplasmic vesicle Membrane Nucleotide-binding Phosphoprotein Reference proteome Synapse | MNFLRRRLSD | MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGS... | neurotransmitter secretion regulation of synaptic transmission, GABAergic synaptic vesicle clustering extrinsic component of synaptic vesicle membrane; glutamatergic synapse; postsynaptic density; synaptic vesicle; synaptic vesicle membrane ATP binding Homo sapiens 3D-structure ATP-binding Calcium Cytoplasmic vesicle M... |
apoptotic process negative regulation of apoptotic process protein K11-linked ubiquitination protein K33-linked ubiquitination protein polyubiquitination protein ubiquitination regulation of inflammatory response ubiquitin-dependent protein catabolic process | cytoplasm; cytosol | ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | 3D-structure Alternative splicing Apoptosis Reference proteome Transferase Ubl conjugation Ubl conjugation pathway | MFYVIGGITV | MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMT... | apoptotic process negative regulation of apoptotic process protein K11-linked ubiquitination protein K33-linked ubiquitination protein polyubiquitination protein ubiquitination regulation of inflammatory response ubiquitin-dependent protein catabolic process cytoplasm; cytosol ubiquitin protein ligase activity ubiquiti... |
axon guidance branching involved in blood vessel morphogenesis gonadotrophin-releasing hormone neuronal migration to the hypothalamus negative chemotaxis negative regulation of angiogenesis negative regulation of axon extension involved in axon guidance negative regulation of cell-matrix adhesion negative regulation of... | extracellular region; extracellular space | chemorepellent activity receptor ligand activity semaphorin receptor binding | Homo sapiens | Alternative splicing Angiogenesis Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Neurogenesis Reference proteome Secreted Signal | MASAGHIITL | MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDH... | axon guidance branching involved in blood vessel morphogenesis gonadotrophin-releasing hormone neuronal migration to the hypothalamus negative chemotaxis negative regulation of angiogenesis negative regulation of axon extension involved in axon guidance negative regulation of cell-matrix adhesion negative regulation of... |
negative regulation of transcription by RNA polymerase II regulation of cytokine production regulation of immune system process | nucleoplasm | DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MGMRIKLQST | MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLDAARTYVVDFITPANFEKVLSFVYTSELFTDLINVGVIYEVAERLGMEDLLQACHSTFPDLESTARAKPLTSTSESHSGTLSCPSAEPAHPLGELRGGGDYLGADRNYVLPSDAGGSYKEEEKNVASDANHSLHLPQPPPPPPKTEDHDTPAPFTSIPSMMTQPLLGTVSTGIQTSTSSCQPYKVQSNGDFSKNSFLTPDNAVDITTGTNSCLSNSEHSKDPGFGQMDELQLEDLGDDDLQFEDPAEDIGTTEEVI... | negative regulation of transcription by RNA polymerase II regulation of cytokine production regulation of immune system process nucleoplasm DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens DNA-bi... |
negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding | Homo sapiens | DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MDFPGHFEQI | MDFPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFSVAEGDQTMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKRKQSAEERARQRLRPSIDESAISDVTPENGPSGVHSREEFFSPDSLKIVDNPKADGMTDNQEDSAIMFDQSFGTQEDAQVPSQSDNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLG... | negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II transcription r... |
anterograde axonal transport anterograde dendritic transport of neurotransmitter receptor complex cilium assembly determination of left/right symmetry intraciliary transport microtubule-based movement mitotic centrosome separation mitotic spindle assembly mitotic spindle organization opsin transport plus-end-directed v... | axon cytoplasm; centrosome; ciliary tip; cilium; cytosol; dendrite; dendrite cytoplasm; dendritic spine; extracellular exosome; kinesin complex; kinesin II complex; membrane; microtubule; microtubule cytoskeleton; midbody; plus-end kinesin complex | ATP binding ATP hydrolysis activity intraciliary transport particle B binding microtubule binding microtubule motor activity plus-end-directed microtubule motor activity small GTPase binding | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Cell projection Ciliopathy Coiled coil Cytoplasm Cytoskeleton Disease variant Microtubule Motor protein Nucleotide-binding Reference proteome Retinitis pigmentosa Synapse | MSKLKSSESV | MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPA... | anterograde axonal transport anterograde dendritic transport of neurotransmitter receptor complex cilium assembly determination of left/right symmetry intraciliary transport microtubule-based movement mitotic centrosome separation mitotic spindle assembly mitotic spindle organization opsin transport plus-end-directed v... |
axon extension central nervous system development central nervous system projection neuron axonogenesis dendrite morphogenesis endosomal transport forebrain development intracellular signal transduction negative regulation of protein localization to nucleus nervous system development neuron migration neuron projection ... | plasma membrane; postsynaptic density | ATP binding protein kinase activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Developmental protein Differentiation Kinase Neurogenesis Nucleotide-binding Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Transferase | MSFGRDMELE | MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGS... | axon extension central nervous system development central nervous system projection neuron axonogenesis dendrite morphogenesis endosomal transport forebrain development intracellular signal transduction negative regulation of protein localization to nucleus nervous system development neuron migration neuron projection ... |
neuron differentiation neurotransmitter secretion synaptic vesicle docking | cytoplasm; cytoplasmic microtubule; membrane; mitochondrion; neuron projection; presynapse | syntaxin-1 binding | Homo sapiens | Alternative splicing Coiled coil Membrane Phosphoprotein Reference proteome Synapse Synaptosome Transmembrane Transmembrane helix | MAMSLPGSRR | MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGMEAGVQASCMQERAIQTDFVQ... | neuron differentiation neurotransmitter secretion synaptic vesicle docking cytoplasm; cytoplasmic microtubule; membrane; mitochondrion; neuron projection; presynapse syntaxin-1 binding Homo sapiens Alternative splicing Coiled coil Membrane Phosphoprotein Reference proteome Synapse Synaptosome Transmembrane Transmembran... |
maintenance of presynaptic active zone structure neuromuscular synaptic transmission regulation of calcium-dependent activation of synaptic vesicle fusion regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic plasticity synaptic vesicle priming | cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; growth cone; presynaptic active zone; presynaptic membrane | structural constituent of presynaptic active zone | Homo sapiens | Cell projection Coiled coil Cytoplasm Cytoskeleton Phosphoprotein Reference proteome Synapse | MYGSARTITN | MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSK... | maintenance of presynaptic active zone structure neuromuscular synaptic transmission regulation of calcium-dependent activation of synaptic vesicle fusion regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic plasticity synaptic vesicle priming cytoskeleton of presynaptic active zone; GAB... |
mitochondrial tRNA 5'-end processing tRNA 5'-leader removal | mitochondrial matrix; mitochondrial nucleoid; mitochondrial ribonuclease P complex; mitochondrion; nucleoplasm | metal ion binding ribonuclease P activity | Homo sapiens | 3D-structure Alternative splicing Disease variant Hydrolase Magnesium Manganese Metal-binding Mitochondrion Nuclease Phosphoprotein Primary mitochondrial disease Reference proteome Transit peptide tRNA processing Zinc | MTFYLFGIRS | MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFA... | mitochondrial tRNA 5'-end processing tRNA 5'-leader removal mitochondrial matrix; mitochondrial nucleoid; mitochondrial ribonuclease P complex; mitochondrion; nucleoplasm metal ion binding ribonuclease P activity Homo sapiens 3D-structure Alternative splicing Disease variant Hydrolase Magnesium Manganese Metal-binding ... |
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