Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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deadenylation-dependent decapping of nuclear-transcribed mRNA histone mRNA catabolic process mRNA processing negative regulation of neuron differentiation neuron differentiation RNA splicing RNA splicing, via transesterification reactions stem cell population maintenance | axon; cytoplasm; cytosol; dendrite; Lsm1-7-Pat1 complex; messenger ribonucleoprotein complex; neuronal cell body; nucleus; P-body | mRNA binding pre-mRNA binding RNA binding RNA cap binding | Homo sapiens | Cytoplasm mRNA processing mRNA splicing Phosphoprotein Reference proteome Ribonucleoprotein RNA-binding | MNYMPGTASL | MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY | deadenylation-dependent decapping of nuclear-transcribed mRNA histone mRNA catabolic process mRNA processing negative regulation of neuron differentiation neuron differentiation RNA splicing RNA splicing, via transesterification reactions stem cell population maintenance axon; cytoplasm; cytosol; dendrite; Lsm1-7-Pat1 complex; messenger ribonucleoprotein complex; neuronal cell body; nucleus; P-body mRNA binding pre-mRNA binding RNA binding RNA cap binding Homo sapiens Cytoplasm mRNA processing mRNA splicing Phosphoprotein Reference proteome Ribonucleoprotein RNA-binding MNYMPGTASL MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY |
immune response integrin-mediated signaling pathway protein localization to plasma membrane T cell receptor signaling pathway | actin cytoskeleton; anchoring junction; cytosol; nucleus; plasma membrane; protein-containing complex | lipid binding protein-containing complex binding signaling receptor binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell junction Coiled coil Cytoplasm Direct protein sequencing Disease variant Nucleus Phosphoprotein Reference proteome Repeat SH3 domain | MAKYNTGGNP | MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND | immune response integrin-mediated signaling pathway protein localization to plasma membrane T cell receptor signaling pathway actin cytoskeleton; anchoring junction; cytosol; nucleus; plasma membrane; protein-containing complex lipid binding protein-containing complex binding signaling receptor binding Homo sapiens 3D-structure Acetylation Alternative splicing Cell junction Coiled coil Cytoplasm Direct protein sequencing Disease variant Nucleus Phosphoprotein Reference proteome Repeat SH3 domain MAKYNTGGNP MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND |
CDP-diacylglycerol biosynthetic process epidermis development phosphatidic acid biosynthetic process phospholipid metabolic process positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway response to xenobiotic stimulus triglyceride biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; specific granule membrane | 1-acylglycerol-3-phosphate O-acyltransferase activity | Homo sapiens | Acyltransferase Alternative splicing Congenital generalized lipodystrophy Diabetes mellitus Disease variant Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Reference proteome Signal Transferase Transmembrane Transmembrane helix | MELWPCLAAA | MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ | CDP-diacylglycerol biosynthetic process epidermis development phosphatidic acid biosynthetic process phospholipid metabolic process positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway response to xenobiotic stimulus triglyceride biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; specific granule membrane 1-acylglycerol-3-phosphate O-acyltransferase activity Homo sapiens Acyltransferase Alternative splicing Congenital generalized lipodystrophy Diabetes mellitus Disease variant Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Reference proteome Signal Transferase Transmembrane Transmembrane helix MELWPCLAAA MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ |
ceramide biosynthetic process myelin maintenance sphingolipid biosynthetic process unsaturated fatty acid biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrion; plasma membrane; specific granule membrane | electron transfer activity retinol isomerase activity sphingolipid delta-4 desaturase activity | Homo sapiens | Disease variant Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Isomerase Leukodystrophy Lipid biosynthesis Lipid metabolism Lipoprotein Membrane Mitochondrion Myristate Oxidoreductase Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MGSRVSREDF | MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE | ceramide biosynthetic process myelin maintenance sphingolipid biosynthetic process unsaturated fatty acid biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrion; plasma membrane; specific granule membrane electron transfer activity retinol isomerase activity sphingolipid delta-4 desaturase activity Homo sapiens Disease variant Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Isomerase Leukodystrophy Lipid biosynthesis Lipid metabolism Lipoprotein Membrane Mitochondrion Myristate Oxidoreductase Phosphoprotein Reference proteome Transmembrane Transmembrane helix MGSRVSREDF MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE |
angiogenesis animal organ regeneration cellular response to growth factor stimulus gene expression germ cell development glomerulus vasculature development maternal process involved in female pregnancy negative regulation of angiogenesis negative regulation of blood vessel endothelial cell migration negative regulation of cell-substrate adhesion negative regulation of positive chemotaxis positive regulation of angiogenesis response to activity response to glucose response to hypoxia response to mechanical stimulus response to organic cyclic compound signal transduction Tie signaling pathway | cell projection; collagen-containing extracellular matrix; extracellular region; extracellular space | metal ion binding receptor tyrosine kinase binding signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Angiogenesis Calcium Coiled coil Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Metal-binding Reference proteome Secreted Signal | MWQIVFFTLS | MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF | angiogenesis animal organ regeneration cellular response to growth factor stimulus gene expression germ cell development glomerulus vasculature development maternal process involved in female pregnancy negative regulation of angiogenesis negative regulation of blood vessel endothelial cell migration negative regulation of cell-substrate adhesion negative regulation of positive chemotaxis positive regulation of angiogenesis response to activity response to glucose response to hypoxia response to mechanical stimulus response to organic cyclic compound signal transduction Tie signaling pathway cell projection; collagen-containing extracellular matrix; extracellular region; extracellular space metal ion binding receptor tyrosine kinase binding signaling receptor binding Homo sapiens 3D-structure Alternative splicing Angiogenesis Calcium Coiled coil Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Metal-binding Reference proteome Secreted Signal MWQIVFFTLS MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF |
endocytosis establishment of localization in cell exocytosis post-Golgi vesicle-mediated transport protein transport | clathrin-coated vesicle; membrane; plasma membrane; recycling endosome membrane; specific granule membrane; synaptic vesicle membrane; trans-Golgi network; trans-Golgi network membrane; zymogen granule membrane | protein domain specific binding | Homo sapiens | Acetylation Alternative splicing Endosome Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MSDFDSNPFA | MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGNCGWISSLTGLNQNIPVGIMMIIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFKGNQI | endocytosis establishment of localization in cell exocytosis post-Golgi vesicle-mediated transport protein transport clathrin-coated vesicle; membrane; plasma membrane; recycling endosome membrane; specific granule membrane; synaptic vesicle membrane; trans-Golgi network; trans-Golgi network membrane; zymogen granule membrane protein domain specific binding Homo sapiens Acetylation Alternative splicing Endosome Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport MSDFDSNPFA MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGNCGWISSLTGLNQNIPVGIMMIIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFKGNQI |
chemical synaptic transmission excitatory postsynaptic potential neuropeptide signaling pathway | axon terminus; dendrite; extracellular region; extracellular space; perikaryon; postsynapse | G protein-coupled receptor binding neuropeptide hormone activity signaling receptor binding | Homo sapiens | Alternative splicing Amidation Cleavage on pair of basic residues Neuropeptide Reference proteome Secreted Signal | MDSRQAAALL | MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKK | chemical synaptic transmission excitatory postsynaptic potential neuropeptide signaling pathway axon terminus; dendrite; extracellular region; extracellular space; perikaryon; postsynapse G protein-coupled receptor binding neuropeptide hormone activity signaling receptor binding Homo sapiens Alternative splicing Amidation Cleavage on pair of basic residues Neuropeptide Reference proteome Secreted Signal MDSRQAAALL MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKK |
NLS-bearing protein import into nucleus protein import into nucleus | cytosol; NLS-dependent protein nuclear import complex; nucleoplasm; nucleus | nuclear import signal receptor activity nuclear localization sequence binding | Homo sapiens | 3D-structure Cytoplasm Host-virus interaction Protein transport Reference proteome Repeat Transport | MDAMASPGKD | MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL | NLS-bearing protein import into nucleus protein import into nucleus cytosol; NLS-dependent protein nuclear import complex; nucleoplasm; nucleus nuclear import signal receptor activity nuclear localization sequence binding Homo sapiens 3D-structure Cytoplasm Host-virus interaction Protein transport Reference proteome Repeat Transport MDAMASPGKD MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL |
Arp2/3 complex-mediated actin nucleation response to estradiol response to estrogen | actin cytoskeleton; Arp2/3 protein complex; cytosol; extracellular exosome; focal adhesion; nucleus; tubulobulbar complex | actin binding protein-containing complex binding structural constituent of cytoskeleton | Homo sapiens | 3D-structure Actin-binding Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Nucleus Reference proteome Repeat WD repeat | MAYHSFLVEP | MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK | Arp2/3 complex-mediated actin nucleation response to estradiol response to estrogen actin cytoskeleton; Arp2/3 protein complex; cytosol; extracellular exosome; focal adhesion; nucleus; tubulobulbar complex actin binding protein-containing complex binding structural constituent of cytoskeleton Homo sapiens 3D-structure Actin-binding Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Nucleus Reference proteome Repeat WD repeat MAYHSFLVEP MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK |
actin filament polymerization actin polymerization-dependent cell motility Arp2/3 complex-mediated actin nucleation positive regulation of actin filament polymerization positive regulation of lamellipodium assembly positive regulation of substrate adhesion-dependent cell spreading | actin cytoskeleton; Arp2/3 protein complex; cytosol; endosome; extracellular exosome; focal adhesion; glutamatergic synapse; lamellipodium; muscle cell projection membrane; neuron projection; nucleoplasm; nucleus; site of double-strand break | actin binding structural constituent of cytoskeleton | Homo sapiens | 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Nucleus Reference proteome Synapse Synaptosome | MILLEVNNRI | MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR | actin filament polymerization actin polymerization-dependent cell motility Arp2/3 complex-mediated actin nucleation positive regulation of actin filament polymerization positive regulation of lamellipodium assembly positive regulation of substrate adhesion-dependent cell spreading actin cytoskeleton; Arp2/3 protein complex; cytosol; endosome; extracellular exosome; focal adhesion; glutamatergic synapse; lamellipodium; muscle cell projection membrane; neuron projection; nucleoplasm; nucleus; site of double-strand break actin binding structural constituent of cytoskeleton Homo sapiens 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Nucleus Reference proteome Synapse Synaptosome MILLEVNNRI MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR |
actin polymerization-dependent cell motility Arp2/3 complex-mediated actin nucleation cellular response to nerve growth factor stimulus regulation of actin filament polymerization | actin cytoskeleton; Arp2/3 protein complex; cytosol; extracellular exosome; filamentous actin; focal adhesion; growth cone leading edge; lamellipodium; membrane; nucleus; site of double-strand break | actin binding structural constituent of cytoskeleton | Homo sapiens | 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation | MPAYHSSLMD | MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ | actin polymerization-dependent cell motility Arp2/3 complex-mediated actin nucleation cellular response to nerve growth factor stimulus regulation of actin filament polymerization actin cytoskeleton; Arp2/3 protein complex; cytosol; extracellular exosome; filamentous actin; focal adhesion; growth cone leading edge; lamellipodium; membrane; nucleus; site of double-strand break actin binding structural constituent of cytoskeleton Homo sapiens 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation MPAYHSSLMD MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ |
cell differentiation memory neuromuscular junction development positive regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein geranylgeranylation positive regulation of protein phosphorylation protein autophosphorylation regulation of synaptic assembly at neuromuscular junction skeletal muscle acetylcholine-gated channel clustering transmembrane receptor protein tyrosine kinase signaling pathway | neuromuscular junction; plasma membrane; postsynaptic membrane; receptor complex | ATP binding metal ion binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity Wnt-protein binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell membrane Congenital myasthenic syndrome Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Kinase Magnesium Membrane Metal-binding Muscle protein Nucleotide-binding Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Repeat Signal Synapse Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase Ubl conjugation | MRELVNIPLV | MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV | cell differentiation memory neuromuscular junction development positive regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein geranylgeranylation positive regulation of protein phosphorylation protein autophosphorylation regulation of synaptic assembly at neuromuscular junction skeletal muscle acetylcholine-gated channel clustering transmembrane receptor protein tyrosine kinase signaling pathway neuromuscular junction; plasma membrane; postsynaptic membrane; receptor complex ATP binding metal ion binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity Wnt-protein binding Homo sapiens 3D-structure Alternative splicing ATP-binding Cell membrane Congenital myasthenic syndrome Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Kinase Magnesium Membrane Metal-binding Muscle protein Nucleotide-binding Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Repeat Signal Synapse Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase Ubl conjugation MRELVNIPLV MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV |
atrial septum development atrioventricular valve morphogenesis cellular response to hypoxia DNA damage response, signal transduction by p53 class mediator endocardial cushion morphogenesis heart valve development negative regulation of apoptotic process negative regulation of cell population proliferation negative regulation of DNA-templated transcription negative regulation of protein catabolic process negative regulation of transcription by RNA polymerase II protein stabilization protein ubiquitination protein-containing complex assembly regulation of cell cycle ventricular septum development | nucleoplasm; nucleus; transcription repressor complex | enzyme binding ubiquitin-protein transferase activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Disease variant Metal-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation Zinc Zinc-finger | MTSFSTSAQC | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA | atrial septum development atrioventricular valve morphogenesis cellular response to hypoxia DNA damage response, signal transduction by p53 class mediator endocardial cushion morphogenesis heart valve development negative regulation of apoptotic process negative regulation of cell population proliferation negative regulation of DNA-templated transcription negative regulation of protein catabolic process negative regulation of transcription by RNA polymerase II protein stabilization protein ubiquitination protein-containing complex assembly regulation of cell cycle ventricular septum development nucleoplasm; nucleus; transcription repressor complex enzyme binding ubiquitin-protein transferase activity zinc ion binding Homo sapiens 3D-structure Alternative splicing Disease variant Metal-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation Zinc Zinc-finger MTSFSTSAQC MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA |
endoplasmic reticulum to Golgi vesicle-mediated transport protein transport vesicle fusion with Golgi apparatus | endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi membrane; membrane; SNARE complex; transport vesicle | SNAP receptor activity | Homo sapiens | 3D-structure Alternative splicing Coiled coil Endoplasmic reticulum ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MRRAGLGEGV | MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVTAIKSLSIEIGHEVKTQNKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMMLFSLFVFFIIYWIIKLR | endoplasmic reticulum to Golgi vesicle-mediated transport protein transport vesicle fusion with Golgi apparatus endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi membrane; membrane; SNARE complex; transport vesicle SNAP receptor activity Homo sapiens 3D-structure Alternative splicing Coiled coil Endoplasmic reticulum ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport MRRAGLGEGV MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVTAIKSLSIEIGHEVKTQNKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMMLFSLFVFFIIYWIIKLR |
adaptive thermogenesis ectoderm development lactation negative regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of gene expression negative regulation of NK T cell proliferation negative regulation of T-helper 17 cell differentiation negative regulation of transcription by RNA polymerase II NK T cell differentiation positive regulation of brown fat cell differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cold-induced thermogenesis positive regulation of gene expression positive regulation of insulin receptor signaling pathway positive regulation of interleukin-17 production positive regulation of SREBP signaling pathway regulation of transcription by RNA polymerase II response to insulin transcription by RNA polymerase II | nucleoplasm | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity histone deacetylase binding metal ion binding protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Acetylation Alternative splicing Developmental protein Differentiation DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MGSPEDDLIG | MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSGTATGGAGAGVCELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERARQYLEAFATATASGVPNGEDSPPQVPLPPPPPPPPRPVARRSRKPRKAFLQTKGARANHLVPEVPTVPAHPLTYEEEEVAGRVGSSGGSGPGDSYSPPTGTASPPEGPQSYEPYEGEEEEEELVYPPAYGLAQGGGPPLSPEELGSDEDAIDPDLMAYLSSLHQDNLAPGLDSQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDKLKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQRHLKGQNCLEVRTRRRRKDDAPPHYPPPSTAAASPAGLDLSNGHLDTFRLSLARFWEQSAPTGPPVSTPGPPDDDEEEGAPTTPQAEGAMESS | adaptive thermogenesis ectoderm development lactation negative regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of gene expression negative regulation of NK T cell proliferation negative regulation of T-helper 17 cell differentiation negative regulation of transcription by RNA polymerase II NK T cell differentiation positive regulation of brown fat cell differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cold-induced thermogenesis positive regulation of gene expression positive regulation of insulin receptor signaling pathway positive regulation of interleukin-17 production positive regulation of SREBP signaling pathway regulation of transcription by RNA polymerase II response to insulin transcription by RNA polymerase II nucleoplasm DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity histone deacetylase binding metal ion binding protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Acetylation Alternative splicing Developmental protein Differentiation DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger MGSPEDDLIG MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSGTATGGAGAGVCELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERARQYLEAFATATASGVPNGEDSPPQVPLPPPPPPPPRPVARRSRKPRKAFLQTKGARANHLVPEVPTVPAHPLTYEEEEVAGRVGSSGGSGPGDSYSPPTGTASPPEGPQSYEPYEGEEEEEELVYPPAYGLAQGGGPPLSPEELGSDEDAIDPDLMAYLSSLHQDNLAPGLDSQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDKLKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQRHLKGQNCLEVRTRRRRKDDAPPHYPPPSTAAASPAGLDLSNGHLDTFRLSLARFWEQSAPTGPPVSTPGPPDDDEEEGAPTTPQAEGAMESS |
transcription by RNA polymerase I | cytoplasm; cytosol; fibrillar center; nucleoplasm; nucleus; RNA polymerase I complex; RNA polymerase III complex | DNA binding DNA-directed 5'-3' RNA polymerase activity protein dimerization activity RNA polymerase I activity RNA polymerase III activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant DNA-directed RNA polymerase Leukodystrophy Nucleus Phosphoprotein Reference proteome Transcription | MAASQAVEEM | MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD | transcription by RNA polymerase I cytoplasm; cytosol; fibrillar center; nucleoplasm; nucleus; RNA polymerase I complex; RNA polymerase III complex DNA binding DNA-directed 5'-3' RNA polymerase activity protein dimerization activity RNA polymerase I activity RNA polymerase III activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant DNA-directed RNA polymerase Leukodystrophy Nucleus Phosphoprotein Reference proteome Transcription MAASQAVEEM MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD |
acute-phase response apoptotic process defense response to virus negative regulation of phagocytosis negative regulation of viral genome replication phosphatidylserine biosynthetic process phosphatidylserine exposure on apoptotic cell surface plasma membrane phospholipid scrambling platelet activation positive regulation of chromosome separation positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of gene expression positive regulation of innate immune response positive regulation of transcription by RNA polymerase II regulation of Fc receptor mediated stimulatory signaling pathway regulation of mast cell activation response to interferon-beta response to lead ion | collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular exosome; Golgi apparatus; membrane; membrane raft; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane | calcium ion binding CD4 receptor binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific enzyme binding epidermal growth factor receptor binding lead ion binding magnesium ion binding mercury ion binding nuclease activity phospholipid scramblase activity SH3 domain binding virus receptor activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Antiviral defense Calcium Cell membrane Cytoplasm Direct protein sequencing DNA-binding Host cell receptor for virus entry Host-virus interaction Hydrolase Lipid transport Lipoprotein Magnesium Membrane Nuclease Nucleus Palmitate Phosphoprotein Receptor Reference proteome Repeat SH3-binding Transmembrane Transmembrane helix Transport | MDKQNSQMNA | MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW | acute-phase response apoptotic process defense response to virus negative regulation of phagocytosis negative regulation of viral genome replication phosphatidylserine biosynthetic process phosphatidylserine exposure on apoptotic cell surface plasma membrane phospholipid scrambling platelet activation positive regulation of chromosome separation positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of gene expression positive regulation of innate immune response positive regulation of transcription by RNA polymerase II regulation of Fc receptor mediated stimulatory signaling pathway regulation of mast cell activation response to interferon-beta response to lead ion collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular exosome; Golgi apparatus; membrane; membrane raft; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane calcium ion binding CD4 receptor binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific enzyme binding epidermal growth factor receptor binding lead ion binding magnesium ion binding mercury ion binding nuclease activity phospholipid scramblase activity SH3 domain binding virus receptor activity zinc ion binding Homo sapiens 3D-structure Alternative splicing Antiviral defense Calcium Cell membrane Cytoplasm Direct protein sequencing DNA-binding Host cell receptor for virus entry Host-virus interaction Hydrolase Lipid transport Lipoprotein Magnesium Membrane Nuclease Nucleus Palmitate Phosphoprotein Receptor Reference proteome Repeat SH3-binding Transmembrane Transmembrane helix Transport MDKQNSQMNA MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW |
negative regulation of cell migration negative regulation of epithelial to mesenchymal transition negative regulation of SMAD protein signal transduction negative regulation of transforming growth factor beta receptor signaling pathway | early endosome membrane; Golgi membrane; intracellular membrane-bounded organelle; membrane | R-SMAD binding | Homo sapiens | Alternative splicing Disulfide bond Endosome Membrane Reference proteome Signal transduction inhibitor Transmembrane Transmembrane helix | MPEAGFQATN | MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV | negative regulation of cell migration negative regulation of epithelial to mesenchymal transition negative regulation of SMAD protein signal transduction negative regulation of transforming growth factor beta receptor signaling pathway early endosome membrane; Golgi membrane; intracellular membrane-bounded organelle; membrane R-SMAD binding Homo sapiens Alternative splicing Disulfide bond Endosome Membrane Reference proteome Signal transduction inhibitor Transmembrane Transmembrane helix MPEAGFQATN MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV |
adipose tissue development | endomembrane system; endoplasmic reticulum; extracellular region; membrane; nuclear envelope | heme binding heme transmembrane transporter activity nuclear steroid receptor activity steroid binding | Homo sapiens | Alternative splicing Endoplasmic reticulum Glycoprotein Lipid-binding Membrane Nucleus Phosphoprotein Proteoglycan Receptor Reference proteome Secreted Steroid-binding Transmembrane Transmembrane helix | MAAGDGDVKL | MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD | adipose tissue development endomembrane system; endoplasmic reticulum; extracellular region; membrane; nuclear envelope heme binding heme transmembrane transporter activity nuclear steroid receptor activity steroid binding Homo sapiens Alternative splicing Endoplasmic reticulum Glycoprotein Lipid-binding Membrane Nucleus Phosphoprotein Proteoglycan Receptor Reference proteome Secreted Steroid-binding Transmembrane Transmembrane helix MAAGDGDVKL MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD |
anterior/posterior axis specification, embryo cardiac muscle cell myoblast differentiation cell fate specification heart morphogenesis mesoderm development mesoderm formation negative regulation of DNA-binding transcription factor activity negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II primitive streak formation regulation of transcription by RNA polymerase II signal transduction somitogenesis | chromatin; nucleoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific double-stranded DNA binding | Homo sapiens | 3D-structure Activator Alternative splicing Developmental protein Disease variant DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MSSPGTESAG | MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQPGYSQWGWLLPGTSTLCPPANPHPQFGGALSLPSTHSCDRYPTLRSHRSSPYPSPYAHRNNSPTYSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWSVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPLYEGAAAATDIVDSQYDAAAQGRLIASWTPVSPPSM | anterior/posterior axis specification, embryo cardiac muscle cell myoblast differentiation cell fate specification heart morphogenesis mesoderm development mesoderm formation negative regulation of DNA-binding transcription factor activity negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II primitive streak formation regulation of transcription by RNA polymerase II signal transduction somitogenesis chromatin; nucleoplasm; nucleus DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific double-stranded DNA binding Homo sapiens 3D-structure Activator Alternative splicing Developmental protein Disease variant DNA-binding Nucleus Reference proteome Transcription Transcription regulation MSSPGTESAG MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQPGYSQWGWLLPGTSTLCPPANPHPQFGGALSLPSTHSCDRYPTLRSHRSSPYPSPYAHRNNSPTYSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWSVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPLYEGAAAATDIVDSQYDAAAQGRLIASWTPVSPPSM |
cell division centrosome cycle mRNA transport protein transport | centriole; centrosome; ciliary basal body; cytoplasm; microtubule organizing center; nuclear pore nuclear basket; nucleolus; photoreceptor connecting cilium; transcription export complex 2 | calcium ion binding G-protein beta/gamma-subunit complex binding microtubule binding | Homo sapiens | Calcium Cell cycle Cell division Cytoplasm Cytoskeleton Metal-binding Mitosis mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Reference proteome Repeat Translocation Transport | MSLALRSELV | MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI | cell division centrosome cycle mRNA transport protein transport centriole; centrosome; ciliary basal body; cytoplasm; microtubule organizing center; nuclear pore nuclear basket; nucleolus; photoreceptor connecting cilium; transcription export complex 2 calcium ion binding G-protein beta/gamma-subunit complex binding microtubule binding Homo sapiens Calcium Cell cycle Cell division Cytoplasm Cytoskeleton Metal-binding Mitosis mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Reference proteome Repeat Translocation Transport MSLALRSELV MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI |
negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation | extracellular exosome; nucleus | metal ion binding myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity | Homo sapiens | 3D-structure Alternative splicing Hydrolase Magnesium Metal-binding Nucleus Protein phosphatase Reference proteome | MDGPAIITQV | MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR | negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation extracellular exosome; nucleus metal ion binding myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity Homo sapiens 3D-structure Alternative splicing Hydrolase Magnesium Metal-binding Nucleus Protein phosphatase Reference proteome MDGPAIITQV MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR |
actin filament severing actin polymerization or depolymerization barbed-end actin filament capping | actin cytoskeleton; cytoplasm | actin filament binding phosphatidylinositol-4,5-bisphosphate binding structural constituent of cytoskeleton | Homo sapiens | Actin capping Actin-binding Alternative splicing Calcium Reference proteome Repeat | MDISKGLPGM | MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF | actin filament severing actin polymerization or depolymerization barbed-end actin filament capping actin cytoskeleton; cytoplasm actin filament binding phosphatidylinositol-4,5-bisphosphate binding structural constituent of cytoskeleton Homo sapiens Actin capping Actin-binding Alternative splicing Calcium Reference proteome Repeat MDISKGLPGM MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF |
axon guidance ephrin receptor signaling pathway | cytosol; dendrite; extracellular region; plasma membrane | ATP binding ephrin receptor activity signaling receptor activity transmembrane-ephrin receptor activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Direct protein sequencing Glycoprotein Membrane Nucleotide-binding Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix | MATEGAAQLG | MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV | axon guidance ephrin receptor signaling pathway cytosol; dendrite; extracellular region; plasma membrane ATP binding ephrin receptor activity signaling receptor activity transmembrane-ephrin receptor activity Homo sapiens 3D-structure Alternative splicing ATP-binding Direct protein sequencing Glycoprotein Membrane Nucleotide-binding Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix MATEGAAQLG MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV |
anatomical structure morphogenesis BMP signaling pathway cell differentiation cellular response to BMP stimulus positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II SMAD protein signal transduction transforming growth factor beta receptor signaling pathway | chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nucleoplasm; nucleus; SMAD protein complex | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific I-SMAD binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Zinc | MHSTTPISSL | MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS | anatomical structure morphogenesis BMP signaling pathway cell differentiation cellular response to BMP stimulus positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II SMAD protein signal transduction transforming growth factor beta receptor signaling pathway chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nucleoplasm; nucleus; SMAD protein complex DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific I-SMAD binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens 3D-structure Alternative splicing Cytoplasm Disease variant DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Zinc MHSTTPISSL MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS |
immune response negative regulation of cell adhesion proteolysis | collagen-containing extracellular matrix; extracellular region | metalloendopeptidase activity zinc ion binding | Homo sapiens | Alternative splicing Disulfide bond Glycoprotein Hydrolase Metal-binding Metalloprotease Protease Reference proteome Secreted Signal Zinc Zymogen | MLRGISQLPA | MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE | immune response negative regulation of cell adhesion proteolysis collagen-containing extracellular matrix; extracellular region metalloendopeptidase activity zinc ion binding Homo sapiens Alternative splicing Disulfide bond Glycoprotein Hydrolase Metal-binding Metalloprotease Protease Reference proteome Secreted Signal Zinc Zymogen MLRGISQLPA MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE |
aggresome assembly myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction protein modification by small protein conjugation protein ubiquitination proteolysis regulation of mitotic cell cycle phase transition response to tumor necrosis factor response to type II interferon ubiquitin-dependent protein catabolic process | aggresome; cytoplasm; cytosol; fibrillar center; nucleoplasm; nucleus | proteasome binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Nucleus Reference proteome Repeat Ubl conjugation pathway | MAPNASCLCV | MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLACYCIGG | aggresome assembly myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction protein modification by small protein conjugation protein ubiquitination proteolysis regulation of mitotic cell cycle phase transition response to tumor necrosis factor response to type II interferon ubiquitin-dependent protein catabolic process aggresome; cytoplasm; cytosol; fibrillar center; nucleoplasm; nucleus proteasome binding Homo sapiens 3D-structure Acetylation Cytoplasm Nucleus Reference proteome Repeat Ubl conjugation pathway MAPNASCLCV MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLACYCIGG |
regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MEPSPLSPSG | MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN | regulation of transcription by RNA polymerase II chromatin; nucleus DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger MEPSPLSPSG MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN |
negative regulation of cardiac muscle cell apoptotic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Ras protein signal transduction regulation of Ral protein signal transduction | cytosol | guanyl-nucleotide exchange factor activity | Homo sapiens | 3D-structure Alternative splicing Guanine-nucleotide releasing factor Phosphoprotein Reference proteome | MLPRPLRLLL | MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF | negative regulation of cardiac muscle cell apoptotic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Ras protein signal transduction regulation of Ral protein signal transduction cytosol guanyl-nucleotide exchange factor activity Homo sapiens 3D-structure Alternative splicing Guanine-nucleotide releasing factor Phosphoprotein Reference proteome MLPRPLRLLL MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF |
chaperone-mediated protein complex assembly chaperone-mediated protein folding negative regulation of amyloid fibril formation protein folding protein stabilization | cytoplasm; prefoldin complex; protein folding chaperone complex; RPAP3/R2TP/prefoldin-like complex | amyloid-beta binding protein-folding chaperone binding unfolded protein binding | Homo sapiens | 3D-structure Acetylation Chaperone Isopeptide bond Reference proteome Ubl conjugation | MAELIQKKLQ | MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQAAKAGAPGKA | chaperone-mediated protein complex assembly chaperone-mediated protein folding negative regulation of amyloid fibril formation protein folding protein stabilization cytoplasm; prefoldin complex; protein folding chaperone complex; RPAP3/R2TP/prefoldin-like complex amyloid-beta binding protein-folding chaperone binding unfolded protein binding Homo sapiens 3D-structure Acetylation Chaperone Isopeptide bond Reference proteome Ubl conjugation MAELIQKKLQ MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQAAKAGAPGKA |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis | nucleolus; nucleoplasm; small-subunit processome | RNA binding | Homo sapiens | 3D-structure Nucleus Phosphoprotein Reference proteome Repeat WD repeat | METAPKPGKD | METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGARPSALDRFVR | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis nucleolus; nucleoplasm; small-subunit processome RNA binding Homo sapiens 3D-structure Nucleus Phosphoprotein Reference proteome Repeat WD repeat METAPKPGKD METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGARPSALDRFVR |
glutathione metabolic process xenobiotic metabolic process | cytosol | glutathione transferase activity identical protein binding protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Reference proteome Transferase | MAARPKLHYP | MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP | glutathione metabolic process xenobiotic metabolic process cytosol glutathione transferase activity identical protein binding protein homodimerization activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Reference proteome Transferase MAARPKLHYP MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP |
negative regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II | nucleolus; nucleoplasm; nucleus | ATPase activator activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MEKILQMAEG | MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN | negative regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II nucleolus; nucleoplasm; nucleus ATPase activator activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens 3D-structure Alternative splicing DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation MEKILQMAEG MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN |
cerebellum morphogenesis ether lipid biosynthetic process fatty acid metabolic process membrane organization paranodal junction assembly phosphatidic acid biosynthetic process phospholipid biosynthetic process response to fatty acid response to nutrient response to starvation response to xenobiotic stimulus synapse assembly triglyceride biosynthetic process | cytosol; membrane; mitochondrial membrane; peroxisomal matrix; peroxisomal membrane; peroxisome | glycerol-3-phosphate O-acyltransferase activity glycerone-phosphate O-acyltransferase activity | Homo sapiens | Acetylation Acyltransferase Alternative splicing Cataract Direct protein sequencing Disease variant Dwarfism Membrane Peroxisome Phosphoprotein Reference proteome Rhizomelic chondrodysplasia punctata Transferase | MESSSSSNSY | MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPATAKL | cerebellum morphogenesis ether lipid biosynthetic process fatty acid metabolic process membrane organization paranodal junction assembly phosphatidic acid biosynthetic process phospholipid biosynthetic process response to fatty acid response to nutrient response to starvation response to xenobiotic stimulus synapse assembly triglyceride biosynthetic process cytosol; membrane; mitochondrial membrane; peroxisomal matrix; peroxisomal membrane; peroxisome glycerol-3-phosphate O-acyltransferase activity glycerone-phosphate O-acyltransferase activity Homo sapiens Acetylation Acyltransferase Alternative splicing Cataract Direct protein sequencing Disease variant Dwarfism Membrane Peroxisome Phosphoprotein Reference proteome Rhizomelic chondrodysplasia punctata Transferase MESSSSSNSY MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPATAKL |
de novo' NAD biosynthetic process from tryptophan anthranilate metabolic process cellular response to interleukin-1 cellular response to lipopolysaccharide kynurenic acid biosynthetic process kynurenine metabolic process L-kynurenine metabolic process NAD metabolic process positive regulation of glutamate secretion, neurotransmission quinolinate biosynthetic process response to salt stress tryptophan catabolic process | cytosol; extracellular space; mitochondrial outer membrane | FAD binding flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity NAD(P)H oxidase H2O2-forming activity | Homo sapiens | 3D-structure Alternative splicing FAD Flavoprotein Glycoprotein Membrane Mitochondrion Mitochondrion outer membrane Monooxygenase NADP Oxidoreductase Pyridine nucleotide biosynthesis Reference proteome Transmembrane Transmembrane helix | MDSSVIQRKK | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR | de novo' NAD biosynthetic process from tryptophan anthranilate metabolic process cellular response to interleukin-1 cellular response to lipopolysaccharide kynurenic acid biosynthetic process kynurenine metabolic process L-kynurenine metabolic process NAD metabolic process positive regulation of glutamate secretion, neurotransmission quinolinate biosynthetic process response to salt stress tryptophan catabolic process cytosol; extracellular space; mitochondrial outer membrane FAD binding flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity NAD(P)H oxidase H2O2-forming activity Homo sapiens 3D-structure Alternative splicing FAD Flavoprotein Glycoprotein Membrane Mitochondrion Mitochondrion outer membrane Monooxygenase NADP Oxidoreductase Pyridine nucleotide biosynthesis Reference proteome Transmembrane Transmembrane helix MDSSVIQRKK MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR |
cartilage development extracellular matrix organization skeletal system development | collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular matrix; extracellular region; matrilin complex | calcium ion binding extracellular matrix structural constituent | Homo sapiens | Alternative splicing Coiled coil Disease variant Disulfide bond Dwarfism EGF-like domain Methylation Phosphoprotein Reference proteome Repeat Secreted Signal | MPRPAPARRL | MPRPAPARRLPGLLLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINEYGQIHR | cartilage development extracellular matrix organization skeletal system development collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular matrix; extracellular region; matrilin complex calcium ion binding extracellular matrix structural constituent Homo sapiens Alternative splicing Coiled coil Disease variant Disulfide bond Dwarfism EGF-like domain Methylation Phosphoprotein Reference proteome Repeat Secreted Signal MPRPAPARRL MPRPAPARRLPGLLLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINEYGQIHR |
intracellular mRNA localization mRNA export from nucleus mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translation | cytoplasmic stress granule; cytosol; dendrite; exon-exon junction complex; nuclear membrane; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; U2-type catalytic step 1 spliceosome | enzyme binding identical protein binding mRNA binding RNA binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure ADP-ribosylation Cell projection Coiled coil Cytoplasm mRNA processing mRNA splicing mRNA transport Nonsense-mediated mRNA decay Nucleus Phosphoprotein Reference proteome RNA-binding Spliceosome Stress response Translation regulation Transport Ubl conjugation | MADRRRQRAS | MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS | intracellular mRNA localization mRNA export from nucleus mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translation cytoplasmic stress granule; cytosol; dendrite; exon-exon junction complex; nuclear membrane; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; U2-type catalytic step 1 spliceosome enzyme binding identical protein binding mRNA binding RNA binding ubiquitin protein ligase binding Homo sapiens 3D-structure ADP-ribosylation Cell projection Coiled coil Cytoplasm mRNA processing mRNA splicing mRNA transport Nonsense-mediated mRNA decay Nucleus Phosphoprotein Reference proteome RNA-binding Spliceosome Stress response Translation regulation Transport Ubl conjugation MADRRRQRAS MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS |
carbohydrate homeostasis defense response to bacterium generation of precursor metabolites and energy glucose homeostasis insulin secretion ovarian follicle development regulation of neuronal synaptic plasticity regulation of synaptic plasticity response to cAMP response to cold response to dietary excess response to insulin sexual reproduction synaptic signaling via neuropeptide | cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular space; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; neuronal cell body; transport vesicle | growth factor activity hormone activity neuropeptide hormone activity | Homo sapiens | 3D-structure Amidation Antibiotic Antimicrobial Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Growth factor Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MKALRLSASA | MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP | carbohydrate homeostasis defense response to bacterium generation of precursor metabolites and energy glucose homeostasis insulin secretion ovarian follicle development regulation of neuronal synaptic plasticity regulation of synaptic plasticity response to cAMP response to cold response to dietary excess response to insulin sexual reproduction synaptic signaling via neuropeptide cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular space; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; neuronal cell body; transport vesicle growth factor activity hormone activity neuropeptide hormone activity Homo sapiens 3D-structure Amidation Antibiotic Antimicrobial Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Growth factor Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal MKALRLSASA MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP |
late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of growth hormone receptor signaling pathway negative regulation of protein localization to cell surface negative regulation of receptor signaling pathway via JAK-STAT positive regulation of protein targeting to mitochondrion | endosome; endosome membrane; Golgi apparatus; Golgi membrane | signaling receptor binding | Homo sapiens | Endosome Golgi apparatus Membrane Reference proteome Transmembrane Transmembrane helix | MAGVKALVAL | MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGDDFSWEQW | late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of growth hormone receptor signaling pathway negative regulation of protein localization to cell surface negative regulation of receptor signaling pathway via JAK-STAT positive regulation of protein targeting to mitochondrion endosome; endosome membrane; Golgi apparatus; Golgi membrane signaling receptor binding Homo sapiens Endosome Golgi apparatus Membrane Reference proteome Transmembrane Transmembrane helix MAGVKALVAL MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGDDFSWEQW |
acetylcholine transport activation of cysteine-type endopeptidase activity involved in apoptotic process amine transport amino acid import across plasma membrane body fluid secretion choline transport dopamine transport dopamine uptake epinephrine transport export across plasma membrane histamine transport histamine uptake L-alpha-amino acid transmembrane transport L-arginine import across plasma membrane monoatomic cation transport neurotransmitter transport norepinephrine transport norepinephrine uptake organic cation transport positive regulation of gene expression prostaglandin transport purine-containing compound transmembrane transport putrescine transport serotonin transport serotonin uptake spermidine transport thiamine transmembrane transport toxin transport transport across blood-brain barrier xenobiotic transport xenobiotic transport across blood-brain barrier | apical plasma membrane; basal plasma membrane; basolateral plasma membrane; extracellular exosome; membrane; plasma membrane; presynapse | acetylcholine transmembrane transporter activity amine transmembrane transporter activity choline transmembrane transporter activity efflux transmembrane transporter activity L-amino acid transmembrane transporter activity L-arginine transmembrane transporter activity monoamine transmembrane transporter activity neurotransmitter transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity prostaglandin transmembrane transporter activity putrescine transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity quaternary ammonium group transmembrane transporter activity spermidine transmembrane transporter activity thiamine transmembrane transporter activity toxin transmembrane transporter activity xenobiotic transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MPTTVDDVLE | MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN | acetylcholine transport activation of cysteine-type endopeptidase activity involved in apoptotic process amine transport amino acid import across plasma membrane body fluid secretion choline transport dopamine transport dopamine uptake epinephrine transport export across plasma membrane histamine transport histamine uptake L-alpha-amino acid transmembrane transport L-arginine import across plasma membrane monoatomic cation transport neurotransmitter transport norepinephrine transport norepinephrine uptake organic cation transport positive regulation of gene expression prostaglandin transport purine-containing compound transmembrane transport putrescine transport serotonin transport serotonin uptake spermidine transport thiamine transmembrane transport toxin transport transport across blood-brain barrier xenobiotic transport xenobiotic transport across blood-brain barrier apical plasma membrane; basal plasma membrane; basolateral plasma membrane; extracellular exosome; membrane; plasma membrane; presynapse acetylcholine transmembrane transporter activity amine transmembrane transporter activity choline transmembrane transporter activity efflux transmembrane transporter activity L-amino acid transmembrane transporter activity L-arginine transmembrane transporter activity monoamine transmembrane transporter activity neurotransmitter transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity prostaglandin transmembrane transporter activity putrescine transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity quaternary ammonium group transmembrane transporter activity spermidine transmembrane transporter activity thiamine transmembrane transporter activity toxin transmembrane transporter activity xenobiotic transmembrane transporter activity Homo sapiens Alternative splicing Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport MPTTVDDVLE MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN |
acetylcholine transport acyl carnitine transmembrane transport dopamine transport dopamine uptake epinephrine transport establishment or maintenance of transmembrane electrochemical gradient metanephric proximal tubule development monoamine transport neurotransmitter transport norepinephrine transport organic cation transport prostaglandin transport purine-containing compound transmembrane transport putrescine transport quaternary ammonium group transport serotonin transport serotonin uptake spermidine transport thiamine transmembrane transport thiamine transport toxin transport transport across blood-brain barrier xenobiotic metabolic process xenobiotic transport xenobiotic transport across blood-brain barrier | apical plasma membrane; basal plasma membrane; basolateral plasma membrane; lateral plasma membrane; membrane; plasma membrane; presynapse | (R)-carnitine transmembrane transporter activity acetylcholine transmembrane transporter activity dopamine:sodium symporter activity identical protein binding monoamine transmembrane transporter activity neurotransmitter transmembrane transporter activity norepinephrine:sodium symporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity prostaglandin transmembrane transporter activity putrescine transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity quaternary ammonium group transmembrane transporter activity secondary active organic cation transmembrane transporter activity spermidine transmembrane transporter activity thiamine transmembrane transporter activity toxin transmembrane transporter activity xenobiotic transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MPTVDDILEQ | MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKENTIYLKVQTSEPSGT | acetylcholine transport acyl carnitine transmembrane transport dopamine transport dopamine uptake epinephrine transport establishment or maintenance of transmembrane electrochemical gradient metanephric proximal tubule development monoamine transport neurotransmitter transport norepinephrine transport organic cation transport prostaglandin transport purine-containing compound transmembrane transport putrescine transport quaternary ammonium group transport serotonin transport serotonin uptake spermidine transport thiamine transmembrane transport thiamine transport toxin transport transport across blood-brain barrier xenobiotic metabolic process xenobiotic transport xenobiotic transport across blood-brain barrier apical plasma membrane; basal plasma membrane; basolateral plasma membrane; lateral plasma membrane; membrane; plasma membrane; presynapse (R)-carnitine transmembrane transporter activity acetylcholine transmembrane transporter activity dopamine:sodium symporter activity identical protein binding monoamine transmembrane transporter activity neurotransmitter transmembrane transporter activity norepinephrine:sodium symporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity prostaglandin transmembrane transporter activity putrescine transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity quaternary ammonium group transmembrane transporter activity secondary active organic cation transmembrane transporter activity spermidine transmembrane transporter activity thiamine transmembrane transporter activity toxin transmembrane transporter activity xenobiotic transmembrane transporter activity Homo sapiens Alternative splicing Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport MPTVDDILEQ MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKENTIYLKVQTSEPSGT |
chloride transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of binding regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum signal transduction | chloride channel complex; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; plasma membrane | chloride channel activity glutathione peroxidase activity | Homo sapiens | 3D-structure Chloride Chloride channel Cytoplasm Disease variant Disulfide bond Intellectual disability Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel | MSGLRPGTQV | MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS | chloride transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of binding regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum signal transduction chloride channel complex; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; plasma membrane chloride channel activity glutathione peroxidase activity Homo sapiens 3D-structure Chloride Chloride channel Cytoplasm Disease variant Disulfide bond Intellectual disability Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel MSGLRPGTQV MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS |
fatty acid beta-oxidation using acyl-CoA oxidase lipid homeostasis | cytosol; membrane; peroxisomal matrix; peroxisome | FAD binding fatty acid binding flavin adenine dinucleotide binding pristanoyl-CoA oxidase activity | Homo sapiens | Acetylation Alternative splicing FAD Fatty acid metabolism Flavoprotein Lipid metabolism Oxidoreductase Peroxisome Phosphoprotein Reference proteome | MASTVEGGDT | MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL | fatty acid beta-oxidation using acyl-CoA oxidase lipid homeostasis cytosol; membrane; peroxisomal matrix; peroxisome FAD binding fatty acid binding flavin adenine dinucleotide binding pristanoyl-CoA oxidase activity Homo sapiens Acetylation Alternative splicing FAD Fatty acid metabolism Flavoprotein Lipid metabolism Oxidoreductase Peroxisome Phosphoprotein Reference proteome MASTVEGGDT MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL |
positive regulation of protein localization to plasma membrane protein retention in ER lumen retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum skeletal muscle acetylcholine-gated channel clustering | cell surface; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; plasma membrane | acetylcholine receptor binding | Homo sapiens | Acetylation Golgi apparatus Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MSEGDSVGES | MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS | positive regulation of protein localization to plasma membrane protein retention in ER lumen retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum skeletal muscle acetylcholine-gated channel clustering cell surface; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; plasma membrane acetylcholine receptor binding Homo sapiens Acetylation Golgi apparatus Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix MSEGDSVGES MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS |
actin cytoskeleton organization cell projection organization cell-cell adhesion positive regulation of bicellular tight junction assembly protein localization involved in establishment of planar polarity retina development in camera-type eye signal transduction spermatid differentiation visual behavior | adherens junction; bicellular tight junction; cell-cell junction; cilium; cytoplasm; cytoskeleton; cytosol; membrane; motile cilium; photoreceptor connecting cilium | structural molecule activity | Homo sapiens | 3D-structure Alternative splicing Cell junction Cell projection Ciliopathy Cilium Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Differentiation Disease variant Joubert syndrome Leber congenital amaurosis Nephronophthisis Phosphoprotein Reference proteome Senior-Loken syndrome SH3 domain Spermatogenesis Tight junction | MLARRQRDPL | MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQSRGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQTYDFLGEMRKNAV | actin cytoskeleton organization cell projection organization cell-cell adhesion positive regulation of bicellular tight junction assembly protein localization involved in establishment of planar polarity retina development in camera-type eye signal transduction spermatid differentiation visual behavior adherens junction; bicellular tight junction; cell-cell junction; cilium; cytoplasm; cytoskeleton; cytosol; membrane; motile cilium; photoreceptor connecting cilium structural molecule activity Homo sapiens 3D-structure Alternative splicing Cell junction Cell projection Ciliopathy Cilium Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Differentiation Disease variant Joubert syndrome Leber congenital amaurosis Nephronophthisis Phosphoprotein Reference proteome Senior-Loken syndrome SH3 domain Spermatogenesis Tight junction MLARRQRDPL MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQSRGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQTYDFLGEMRKNAV |
Golgi organization lipid homeostasis lipoprotein transport positive regulation of organelle organization regulation of lipid transport | azurophil granule membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; nuclear membrane; plasma membrane; transport vesicle | cargo receptor activity | Homo sapiens | Alternative splicing Endoplasmic reticulum Golgi apparatus Membrane Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MGQNDLMGTA | MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW | Golgi organization lipid homeostasis lipoprotein transport positive regulation of organelle organization regulation of lipid transport azurophil granule membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; nuclear membrane; plasma membrane; transport vesicle cargo receptor activity Homo sapiens Alternative splicing Endoplasmic reticulum Golgi apparatus Membrane Protein transport Reference proteome Transmembrane Transmembrane helix Transport MGQNDLMGTA MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW |
antifungal innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide cell chemotaxis chemotaxis defense response to bacterium defense response to fungus defense response to Gram-negative bacterium defense response to Gram-positive bacterium G protein-coupled receptor signaling pathway immune response killing of cells of another organism | extracellular region; extracellular space; Golgi lumen | CCR6 chemokine receptor binding chemoattractant activity phosphatidylinositol-4,5-bisphosphate binding | Homo sapiens | 3D-structure Antibiotic Antimicrobial Defensin Disulfide bond Reference proteome Secreted Signal | MRVLYLLFSF | MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP | antifungal innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide cell chemotaxis chemotaxis defense response to bacterium defense response to fungus defense response to Gram-negative bacterium defense response to Gram-positive bacterium G protein-coupled receptor signaling pathway immune response killing of cells of another organism extracellular region; extracellular space; Golgi lumen CCR6 chemokine receptor binding chemoattractant activity phosphatidylinositol-4,5-bisphosphate binding Homo sapiens 3D-structure Antibiotic Antimicrobial Defensin Disulfide bond Reference proteome Secreted Signal MRVLYLLFSF MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP |
cell cycle cellular response to anisomycin cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sodium arsenite cellular response to sorbitol cellular response to UV intracellular signal transduction peptidyl-serine phosphorylation positive regulation of inflammatory response positive regulation of interleukin-6 production response to osmotic stress stress-activated MAPK cascade | cytoplasm; cytosol; nucleus | ATP binding MAP kinase activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell cycle Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Stress response Transcription Transcription regulation Transferase | MSLIRKKGFY | MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL | cell cycle cellular response to anisomycin cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sodium arsenite cellular response to sorbitol cellular response to UV intracellular signal transduction peptidyl-serine phosphorylation positive regulation of inflammatory response positive regulation of interleukin-6 production response to osmotic stress stress-activated MAPK cascade cytoplasm; cytosol; nucleus ATP binding MAP kinase activity protein serine kinase activity protein serine/threonine kinase activity Homo sapiens 3D-structure Alternative splicing ATP-binding Cell cycle Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Stress response Transcription Transcription regulation Transferase MSLIRKKGFY MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL |
positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II skeletal system development | chromatin; intracellular membrane-bounded organelle; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Alternative splicing Developmental protein Disease variant DNA-binding Dwarfism Homeobox Nucleus Reference proteome Transcription Transcription regulation | MEELTAFVSK | MEELTAFVSKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLARSRELGTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL | positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II skeletal system development chromatin; intracellular membrane-bounded organelle; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Activator Alternative splicing Developmental protein Disease variant DNA-binding Dwarfism Homeobox Nucleus Reference proteome Transcription Transcription regulation MEELTAFVSK MEELTAFVSKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLARSRELGTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL |
ceramide biosynthetic process positive regulation of lipophagy regulation of fat cell apoptotic process sphinganine biosynthetic process sphingolipid biosynthetic process sphingolipid metabolic process sphingomyelin biosynthetic process sphingosine biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; serine C-palmitoyltransferase complex; SPOTS complex | pyridoxal phosphate binding serine C-palmitoyltransferase activity | Homo sapiens | 3D-structure Acyltransferase Alternative splicing Amyotrophic lateral sclerosis Disease variant Endoplasmic reticulum Lipid metabolism Membrane Neurodegeneration Neuropathy Phosphoprotein Pyridoxal phosphate Reference proteome Sphingolipid metabolism Transferase Transmembrane Transmembrane helix | MATATEQWVL | MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL | ceramide biosynthetic process positive regulation of lipophagy regulation of fat cell apoptotic process sphinganine biosynthetic process sphingolipid biosynthetic process sphingolipid metabolic process sphingomyelin biosynthetic process sphingosine biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; serine C-palmitoyltransferase complex; SPOTS complex pyridoxal phosphate binding serine C-palmitoyltransferase activity Homo sapiens 3D-structure Acyltransferase Alternative splicing Amyotrophic lateral sclerosis Disease variant Endoplasmic reticulum Lipid metabolism Membrane Neurodegeneration Neuropathy Phosphoprotein Pyridoxal phosphate Reference proteome Sphingolipid metabolism Transferase Transmembrane Transmembrane helix MATATEQWVL MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL |
adipose tissue development ceramide biosynthetic process positive regulation of lipophagy sphinganine biosynthetic process sphingolipid biosynthetic process sphingomyelin biosynthetic process sphingosine biosynthetic process | endoplasmic reticulum membrane; serine C-palmitoyltransferase complex | pyridoxal phosphate binding serine C-palmitoyltransferase activity | Homo sapiens | 3D-structure Acyltransferase Disease variant Endoplasmic reticulum Lipid metabolism Membrane Neurodegeneration Neuropathy Pyridoxal phosphate Reference proteome Sphingolipid metabolism Transferase Transmembrane Transmembrane helix | MRPEPGGCCC | MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED | adipose tissue development ceramide biosynthetic process positive regulation of lipophagy sphinganine biosynthetic process sphingolipid biosynthetic process sphingomyelin biosynthetic process sphingosine biosynthetic process endoplasmic reticulum membrane; serine C-palmitoyltransferase complex pyridoxal phosphate binding serine C-palmitoyltransferase activity Homo sapiens 3D-structure Acyltransferase Disease variant Endoplasmic reticulum Lipid metabolism Membrane Neurodegeneration Neuropathy Pyridoxal phosphate Reference proteome Sphingolipid metabolism Transferase Transmembrane Transmembrane helix MRPEPGGCCC MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED |
adult heart development cardiac muscle cell development cardiac muscle contraction cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress cardiac muscle tissue morphogenesis cardiac myofibril assembly detection of mechanical stimulus detection of muscle stretch otic vesicle formation protein-containing complex assembly response to muscle stretch sarcomere organization sarcomerogenesis skeletal muscle contraction skeletal muscle myosin thick filament assembly skeletal muscle thin filament assembly somitogenesis | cytosol; I band; Z disc | BMP binding FATZ binding molecular adaptor activity protein-macromolecule adaptor activity structural constituent of muscle titin binding titin Z domain binding transmembrane transporter binding | Homo sapiens | 3D-structure Cardiomyopathy Cytoplasm Disease variant Limb-girdle muscular dystrophy Phosphoprotein Reference proteome | MATSELSCEV | MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG | adult heart development cardiac muscle cell development cardiac muscle contraction cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress cardiac muscle tissue morphogenesis cardiac myofibril assembly detection of mechanical stimulus detection of muscle stretch otic vesicle formation protein-containing complex assembly response to muscle stretch sarcomere organization sarcomerogenesis skeletal muscle contraction skeletal muscle myosin thick filament assembly skeletal muscle thin filament assembly somitogenesis cytosol; I band; Z disc BMP binding FATZ binding molecular adaptor activity protein-macromolecule adaptor activity structural constituent of muscle titin binding titin Z domain binding transmembrane transporter binding Homo sapiens 3D-structure Cardiomyopathy Cytoplasm Disease variant Limb-girdle muscular dystrophy Phosphoprotein Reference proteome MATSELSCEV MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG |
DNA damage response DNA repair interstrand cross-link repair mitochondrion organization ovarian follicle development response to radiation spermatid development | chromatin; cytosol; Fanconi anaemia nuclear complex; mitochondrion; nucleolus; nucleoplasm; plasma membrane | damaged DNA binding | Homo sapiens | 3D-structure Cytoplasm Disease variant DNA damage DNA repair Fanconi anemia Nucleus Phosphoprotein Reference proteome Repeat TPR repeat | MSRQTTSVGS | MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL | DNA damage response DNA repair interstrand cross-link repair mitochondrion organization ovarian follicle development response to radiation spermatid development chromatin; cytosol; Fanconi anaemia nuclear complex; mitochondrion; nucleolus; nucleoplasm; plasma membrane damaged DNA binding Homo sapiens 3D-structure Cytoplasm Disease variant DNA damage DNA repair Fanconi anemia Nucleus Phosphoprotein Reference proteome Repeat TPR repeat MSRQTTSVGS MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL |
apoptotic process arachidonic acid metabolic process cannabinoid biosynthetic process endocannabinoid signaling pathway hepoxilin biosynthetic process linoleic acid metabolic process lipid metabolic process lipid oxidation lipoxin A4 biosynthetic process lipoxygenase pathway negative regulation of cell cycle negative regulation of cell migration negative regulation of cell population proliferation negative regulation of growth phospholipid metabolic process positive regulation of chemokine production positive regulation of keratinocyte differentiation positive regulation of macrophage derived foam cell differentiation positive regulation of peroxisome proliferator activated receptor signaling pathway prostate gland development regulation of epithelial cell differentiation | adherens junction; cytoskeleton; cytosol; extracellular exosome; focal adhesion; membrane; nucleus; plasma membrane | arachidonate 15-lipoxygenase activity arachidonate 8(S)-lipoxygenase activity calcium ion binding iron ion binding linoleate 13S-lipoxygenase activity linoleate 9S-lipoxygenase activity lipid binding | Homo sapiens | 3D-structure Alternative splicing Calcium Cell junction Cell membrane Cytoplasm Cytoskeleton Dioxygenase Iron Lipid metabolism Lipid-binding Membrane Metal-binding Nucleus Oxidoreductase Reference proteome | MAEFRVRVST | MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI | apoptotic process arachidonic acid metabolic process cannabinoid biosynthetic process endocannabinoid signaling pathway hepoxilin biosynthetic process linoleic acid metabolic process lipid metabolic process lipid oxidation lipoxin A4 biosynthetic process lipoxygenase pathway negative regulation of cell cycle negative regulation of cell migration negative regulation of cell population proliferation negative regulation of growth phospholipid metabolic process positive regulation of chemokine production positive regulation of keratinocyte differentiation positive regulation of macrophage derived foam cell differentiation positive regulation of peroxisome proliferator activated receptor signaling pathway prostate gland development regulation of epithelial cell differentiation adherens junction; cytoskeleton; cytosol; extracellular exosome; focal adhesion; membrane; nucleus; plasma membrane arachidonate 15-lipoxygenase activity arachidonate 8(S)-lipoxygenase activity calcium ion binding iron ion binding linoleate 13S-lipoxygenase activity linoleate 9S-lipoxygenase activity lipid binding Homo sapiens 3D-structure Alternative splicing Calcium Cell junction Cell membrane Cytoplasm Cytoskeleton Dioxygenase Iron Lipid metabolism Lipid-binding Membrane Metal-binding Nucleus Oxidoreductase Reference proteome MAEFRVRVST MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI |
cellular response to starvation DNA damage response, signal transduction by p53 class mediator DNA methylation G2/M transition of mitotic cell cycle heterochromatin formation negative regulation of cell population proliferation negative regulation of gene expression, epigenetic peptidyl-threonine dephosphorylation protein dephosphorylation regulation of transcription initiation by RNA polymerase II response to bacterium response to radiation | cytosol; nucleolus; nucleoplasm; nucleus | metal ion binding mitogen-activated protein kinase binding myosin phosphatase activity protein serine/threonine kinase activity protein serine/threonine phosphatase activity | Homo sapiens | Alternative splicing Autism spectrum disorder Cell cycle Cytoplasm Disease variant Hydrolase Intellectual disability Magnesium Manganese Metal-binding Nucleus Phosphoprotein Protein phosphatase Reference proteome | MAGLYSLGVS | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC | cellular response to starvation DNA damage response, signal transduction by p53 class mediator DNA methylation G2/M transition of mitotic cell cycle heterochromatin formation negative regulation of cell population proliferation negative regulation of gene expression, epigenetic peptidyl-threonine dephosphorylation protein dephosphorylation regulation of transcription initiation by RNA polymerase II response to bacterium response to radiation cytosol; nucleolus; nucleoplasm; nucleus metal ion binding mitogen-activated protein kinase binding myosin phosphatase activity protein serine/threonine kinase activity protein serine/threonine phosphatase activity Homo sapiens Alternative splicing Autism spectrum disorder Cell cycle Cytoplasm Disease variant Hydrolase Intellectual disability Magnesium Manganese Metal-binding Nucleus Phosphoprotein Protein phosphatase Reference proteome MAGLYSLGVS MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC |
chemical synaptic transmission detection of light stimulus involved in visual perception detection of visible light G protein-coupled glutamate receptor signaling pathway locomotory behavior positive regulation of calcium ion import across plasma membrane regulation of synaptic transmission, glutamatergic retina development in camera-type eye | dendrite; endoplasmic reticulum membrane; Golgi membrane; new growing cell tip; plasma membrane; synapse | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity G protein-coupled receptor activity glutamate receptor activity protein homodimerization activity | Homo sapiens | Cell membrane Cell projection Congenital stationary night blindness Disease variant Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Golgi apparatus Membrane Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Vision | MARPRRAREP | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK | chemical synaptic transmission detection of light stimulus involved in visual perception detection of visible light G protein-coupled glutamate receptor signaling pathway locomotory behavior positive regulation of calcium ion import across plasma membrane regulation of synaptic transmission, glutamatergic retina development in camera-type eye dendrite; endoplasmic reticulum membrane; Golgi membrane; new growing cell tip; plasma membrane; synapse adenylate cyclase inhibiting G protein-coupled glutamate receptor activity G protein-coupled receptor activity glutamate receptor activity protein homodimerization activity Homo sapiens Cell membrane Cell projection Congenital stationary night blindness Disease variant Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Golgi apparatus Membrane Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Vision MARPRRAREP MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK |
activation-induced cell death of T cells extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cytoplasm; mitochondrion; nucleoplasm | CD27 receptor binding metal ion binding tumor necrosis factor receptor binding virus receptor activity zinc ion binding | Homo sapiens | Alternative splicing Apoptosis Cytoplasm Host-virus interaction Metal-binding Nucleus Pharmaceutical Phosphoprotein Reference proteome Zinc | MPKRSCPFAD | MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET | activation-induced cell death of T cells extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway cytoplasm; mitochondrion; nucleoplasm CD27 receptor binding metal ion binding tumor necrosis factor receptor binding virus receptor activity zinc ion binding Homo sapiens Alternative splicing Apoptosis Cytoplasm Host-virus interaction Metal-binding Nucleus Pharmaceutical Phosphoprotein Reference proteome Zinc MPKRSCPFAD MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET |
GDP-mannose biosynthetic process mannose metabolic process protein glycosylation protein N-linked glycosylation | cytosol; neuronal cell body; nucleoplasm | metal ion binding phosphomannomutase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Congenital disorder of glycosylation Cytoplasm Disease variant Isomerase Magnesium Metal-binding Reference proteome | MAAPGPALCL | MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS | GDP-mannose biosynthetic process mannose metabolic process protein glycosylation protein N-linked glycosylation cytosol; neuronal cell body; nucleoplasm metal ion binding phosphomannomutase activity Homo sapiens 3D-structure Acetylation Alternative splicing Congenital disorder of glycosylation Cytoplasm Disease variant Isomerase Magnesium Metal-binding Reference proteome MAAPGPALCL MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS |
blastocyst growth DNA recombination DNA repair double-strand break repair via homologous recombination positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle reciprocal meiotic recombination somite development | nucleoplasm; nucleus; Rad51B-Rad51C-Rad51D-XRCC2 complex; replication fork | ATP binding ATP hydrolysis activity ATP-dependent activity, acting on DNA ATP-dependent DNA damage sensor activity DNA binding double-stranded DNA binding single-stranded DNA binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Chromosomal rearrangement DNA damage DNA recombination DNA repair DNA-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MGSKKLKRVG | MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF | blastocyst growth DNA recombination DNA repair double-strand break repair via homologous recombination positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle reciprocal meiotic recombination somite development nucleoplasm; nucleus; Rad51B-Rad51C-Rad51D-XRCC2 complex; replication fork ATP binding ATP hydrolysis activity ATP-dependent activity, acting on DNA ATP-dependent DNA damage sensor activity DNA binding double-stranded DNA binding single-stranded DNA binding Homo sapiens 3D-structure Alternative splicing ATP-binding Chromosomal rearrangement DNA damage DNA recombination DNA repair DNA-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome MGSKKLKRVG MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF |
cell population proliferation defense response to virus innate immune response positive regulation of innate immune response positive regulation of interferon-beta production regulation of transcription by RNA polymerase III transcription by RNA polymerase III | cytosol; nuclear body; nucleoplasm; nucleus; RNA polymerase III complex | chromatin binding DNA-directed 5'-3' RNA polymerase activity | Homo sapiens | 3D-structure Antiviral defense Cytoplasm DNA-directed RNA polymerase Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Transcription | MAGNKGRGRA | MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY | cell population proliferation defense response to virus innate immune response positive regulation of innate immune response positive regulation of interferon-beta production regulation of transcription by RNA polymerase III transcription by RNA polymerase III cytosol; nuclear body; nucleoplasm; nucleus; RNA polymerase III complex chromatin binding DNA-directed 5'-3' RNA polymerase activity Homo sapiens 3D-structure Antiviral defense Cytoplasm DNA-directed RNA polymerase Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Transcription MAGNKGRGRA MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY |
inositol phosphate metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol dephosphorylation signal transduction | cytoplasm; cytosol | inositol-1,3,4-trisphosphate 4-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | Homo sapiens | Alternative splicing Hydrolase Lipid metabolism Reference proteome | MEIKEEGASE | MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT | inositol phosphate metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol dephosphorylation signal transduction cytoplasm; cytosol inositol-1,3,4-trisphosphate 4-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Homo sapiens Alternative splicing Hydrolase Lipid metabolism Reference proteome MEIKEEGASE MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT |
proton transmembrane transport regulation of macroautophagy transmembrane transport vacuolar acidification | endosome membrane; lysosomal membrane; phagocytic vesicle membrane; proton-transporting V-type ATPase, V0 domain | ATPase-coupled ion transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism | Homo sapiens | 3D-structure Glycoprotein Hydrogen ion transport Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport | MAYHGLTVPL | MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP | proton transmembrane transport regulation of macroautophagy transmembrane transport vacuolar acidification endosome membrane; lysosomal membrane; phagocytic vesicle membrane; proton-transporting V-type ATPase, V0 domain ATPase-coupled ion transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism Homo sapiens 3D-structure Glycoprotein Hydrogen ion transport Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport MAYHGLTVPL MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP |
microtubule cytoskeleton organization negative regulation of microtubule depolymerization pattern specification process positive regulation of stress-activated MAPK cascade protein localization to microtubule regulation of microtubule cytoskeleton organization | centriolar satellite; cytoplasm; cytosol; Golgi apparatus; microtubule; microtubule associated complex; spindle | enzyme binding identical protein binding microtubule binding phosphoprotein binding protein homodimerization activity transferase activity ubiquitin protein ligase binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Metal-binding Microtubule Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger | METLESELTC | METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFMVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHEWIGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIAFYDALNSIHLYTFDVAFAQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP | microtubule cytoskeleton organization negative regulation of microtubule depolymerization pattern specification process positive regulation of stress-activated MAPK cascade protein localization to microtubule regulation of microtubule cytoskeleton organization centriolar satellite; cytoplasm; cytosol; Golgi apparatus; microtubule; microtubule associated complex; spindle enzyme binding identical protein binding microtubule binding phosphoprotein binding protein homodimerization activity transferase activity ubiquitin protein ligase binding zinc ion binding Homo sapiens 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Metal-binding Microtubule Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger METLESELTC METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFMVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHEWIGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIAFYDALNSIHLYTFDVAFAQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP |
DNA geometric change DNA recombination innate immune response negative regulation of B cell differentiation negative regulation of myeloid cell differentiation regulation of transcription by RNA polymerase II | chromosome; cytoplasm; nucleus | DNA binding, bending double-stranded DNA binding four-way junction DNA binding RNA binding | Homo sapiens | 3D-structure Acetylation Chromosome Cytoplasm Disulfide bond DNA-binding Immunity Innate immunity Microphthalmia Nucleus Oxidation Phosphoprotein Reference proteome Repeat Transcription Transcription regulation | MAKGDPKKPK | MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE | DNA geometric change DNA recombination innate immune response negative regulation of B cell differentiation negative regulation of myeloid cell differentiation regulation of transcription by RNA polymerase II chromosome; cytoplasm; nucleus DNA binding, bending double-stranded DNA binding four-way junction DNA binding RNA binding Homo sapiens 3D-structure Acetylation Chromosome Cytoplasm Disulfide bond DNA-binding Immunity Innate immunity Microphthalmia Nucleus Oxidation Phosphoprotein Reference proteome Repeat Transcription Transcription regulation MAKGDPKKPK MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE |
cell cycle DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator kidney development mismatch repair negative regulation of cardiac muscle cell proliferation negative regulation of cell population proliferation negative regulation of neuron differentiation positive regulation of apoptotic process positive regulation of DNA-templated transcription positive regulation of lung ciliated cell differentiation positive regulation of MAPK cascade positive regulation of oligodendrocyte differentiation positive regulation of transcription by RNA polymerase II protein tetramerization regulation of cell cycle regulation of gene expression regulation of mitotic cell cycle regulation of transcription by RNA polymerase II response to organonitrogen compound response to xenobiotic stimulus | cell junction; chromatin; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding identical protein binding MDM2/MDM4 family protein binding metal ion binding p53 binding protein kinase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding transcription cis-regulatory region binding transcription corepressor binding | Homo sapiens | 3D-structure Activator Alternative promoter usage Alternative splicing Apoptosis Cell cycle Ciliopathy Cytoplasm Disease variant DNA-binding Host-virus interaction Isopeptide bond Lissencephaly Metal-binding Nucleus Phosphoprotein Primary ciliary dyskinesia Reference proteome Transcription Transcription regulation Tumor suppressor Ubl conjugation Zinc | MAQSTATSPD | MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH | cell cycle DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator kidney development mismatch repair negative regulation of cardiac muscle cell proliferation negative regulation of cell population proliferation negative regulation of neuron differentiation positive regulation of apoptotic process positive regulation of DNA-templated transcription positive regulation of lung ciliated cell differentiation positive regulation of MAPK cascade positive regulation of oligodendrocyte differentiation positive regulation of transcription by RNA polymerase II protein tetramerization regulation of cell cycle regulation of gene expression regulation of mitotic cell cycle regulation of transcription by RNA polymerase II response to organonitrogen compound response to xenobiotic stimulus cell junction; chromatin; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding identical protein binding MDM2/MDM4 family protein binding metal ion binding p53 binding protein kinase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding transcription cis-regulatory region binding transcription corepressor binding Homo sapiens 3D-structure Activator Alternative promoter usage Alternative splicing Apoptosis Cell cycle Ciliopathy Cytoplasm Disease variant DNA-binding Host-virus interaction Isopeptide bond Lissencephaly Metal-binding Nucleus Phosphoprotein Primary ciliary dyskinesia Reference proteome Transcription Transcription regulation Tumor suppressor Ubl conjugation Zinc MAQSTATSPD MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH |
animal organ morphogenesis blood vessel morphogenesis defense response epidermis development hair follicle development keratinocyte differentiation lymphoid lineage cell migration into thymus nail development positive regulation of epithelial cell differentiation positive regulation of hair follicle development regulation of positive thymic T cell selection regulation of transcription by RNA polymerase II T cell homeostasis T cell lineage commitment thymus epithelium morphogenesis | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding | Homo sapiens | 3D-structure Developmental protein Differentiation Disease variant DNA-binding Hypotrichosis Nucleus Reference proteome Transcription Transcription regulation | MVSLPPPQSD | MVSLPPPQSDVTLPGPTRLEGERQGDLMQAPGLPGSPAPQSKHAGFSCSSFVSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSPGRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLPGFSAEAWCNGLPYPSQEHGPQVLGSEVKVKPPVLESGAGMFCYQPPLQHMYCSSQPPFHQYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSCYGQTYLHLSPGLAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSGGSGALGDLHLTTLYSAFMELEPTPPTAPAGPSVYLSPSSKPVALA | animal organ morphogenesis blood vessel morphogenesis defense response epidermis development hair follicle development keratinocyte differentiation lymphoid lineage cell migration into thymus nail development positive regulation of epithelial cell differentiation positive regulation of hair follicle development regulation of positive thymic T cell selection regulation of transcription by RNA polymerase II T cell homeostasis T cell lineage commitment thymus epithelium morphogenesis chromatin; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding Homo sapiens 3D-structure Developmental protein Differentiation Disease variant DNA-binding Hypotrichosis Nucleus Reference proteome Transcription Transcription regulation MVSLPPPQSD MVSLPPPQSDVTLPGPTRLEGERQGDLMQAPGLPGSPAPQSKHAGFSCSSFVSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSPGRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLPGFSAEAWCNGLPYPSQEHGPQVLGSEVKVKPPVLESGAGMFCYQPPLQHMYCSSQPPFHQYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSCYGQTYLHLSPGLAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSGGSGALGDLHLTTLYSAFMELEPTPPTAPAGPSVYLSPSSKPVALA |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to reactive oxygen species dendrite development dopamine biosynthetic process G protein-coupled receptor signaling pathway locomotion involved in locomotory behavior neuropeptide signaling pathway positive regulation of dopamine metabolic process positive regulation of MAPK cascade | cell surface; cytoplasm; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; receptor complex; synapse; ubiquitin ligase complex | G protein-coupled peptide receptor activity G protein-coupled receptor activity heat shock protein binding Hsp70 protein binding neuropeptide binding neuropeptide receptor activity PDZ domain binding peptide binding prosaposin receptor activity ubiquitin protein ligase binding | Homo sapiens | Cell membrane Cell projection Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Signal Synapse Transducer Transmembrane Transmembrane helix Ubl conjugation | MRAPGALLAR | MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to reactive oxygen species dendrite development dopamine biosynthetic process G protein-coupled receptor signaling pathway locomotion involved in locomotory behavior neuropeptide signaling pathway positive regulation of dopamine metabolic process positive regulation of MAPK cascade cell surface; cytoplasm; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; receptor complex; synapse; ubiquitin ligase complex G protein-coupled peptide receptor activity G protein-coupled receptor activity heat shock protein binding Hsp70 protein binding neuropeptide binding neuropeptide receptor activity PDZ domain binding peptide binding prosaposin receptor activity ubiquitin protein ligase binding Homo sapiens Cell membrane Cell projection Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Signal Synapse Transducer Transmembrane Transmembrane helix Ubl conjugation MRAPGALLAR MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC |
peptidyl-threonine dephosphorylation protein dephosphorylation regulation of cell cycle | cytoplasm; membrane; nucleoplasm; nucleus | metal ion binding myosin phosphatase activity protein serine/threonine phosphatase activity | Homo sapiens | Acetylation Cytoplasm Hydrolase Lipoprotein Magnesium Manganese Membrane Metal-binding Methylation Myristate Phosphoprotein Protein phosphatase Reference proteome Repeat | MGAYLSQPNT | MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD | peptidyl-threonine dephosphorylation protein dephosphorylation regulation of cell cycle cytoplasm; membrane; nucleoplasm; nucleus metal ion binding myosin phosphatase activity protein serine/threonine phosphatase activity Homo sapiens Acetylation Cytoplasm Hydrolase Lipoprotein Magnesium Manganese Membrane Metal-binding Methylation Myristate Phosphoprotein Protein phosphatase Reference proteome Repeat MGAYLSQPNT MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD |
cap-dependent translational initiation formation of cytoplasmic translation initiation complex IRES-dependent viral translational initiation positive regulation of mRNA binding positive regulation of translation translational initiation viral translational termination-reinitiation | cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; membrane; synapse | mRNA cap binding RNA binding translation initiation factor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Host-virus interaction Initiation factor Phosphoprotein Protein biosynthesis Reference proteome RNA-binding | MAKFMTPVIQ | MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET | cap-dependent translational initiation formation of cytoplasmic translation initiation complex IRES-dependent viral translational initiation positive regulation of mRNA binding positive regulation of translation translational initiation viral translational termination-reinitiation cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; membrane; synapse mRNA cap binding RNA binding translation initiation factor activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Host-virus interaction Initiation factor Phosphoprotein Protein biosynthesis Reference proteome RNA-binding MAKFMTPVIQ MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET |
formation of cytoplasmic translation initiation complex negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of translational initiation translational initiation | cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; extracellular exosome; membrane; polysomal ribosome | metal-dependent deubiquitinase activity metallopeptidase activity RNA binding translation initiation factor activity | Homo sapiens | 3D-structure Cytoplasm Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Reference proteome Ubl conjugation | MASRKEGTGS | MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN | formation of cytoplasmic translation initiation complex negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of translational initiation translational initiation cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; extracellular exosome; membrane; polysomal ribosome metal-dependent deubiquitinase activity metallopeptidase activity RNA binding translation initiation factor activity Homo sapiens 3D-structure Cytoplasm Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Reference proteome Ubl conjugation MASRKEGTGS MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN |
monocarboxylic acid transport | membrane; plasma membrane | monocarboxylic acid transmembrane transporter activity symporter activity | Homo sapiens | Alternative splicing Cell membrane Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport | MLKREGKVQP | MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT | monocarboxylic acid transport membrane; plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity Homo sapiens Alternative splicing Cell membrane Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport MLKREGKVQP MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT |
positive regulation of protein binding positive regulation of telomerase activity regulation of protein localization to nucleolus ribosomal large subunit biogenesis ribosome biogenesis rRNA processing | membrane; nucleolus; nucleoplasm; nucleus; telomerase holoenzyme complex | ATP binding ATP hydrolysis activity preribosome binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Isopeptide bond Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Ribosome biogenesis Ubl conjugation | MKPRPAGFVD | MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR | positive regulation of protein binding positive regulation of telomerase activity regulation of protein localization to nucleolus ribosomal large subunit biogenesis ribosome biogenesis rRNA processing membrane; nucleolus; nucleoplasm; nucleus; telomerase holoenzyme complex ATP binding ATP hydrolysis activity preribosome binding RNA binding Homo sapiens 3D-structure Acetylation Alternative splicing ATP-binding Isopeptide bond Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Ribosome biogenesis Ubl conjugation MKPRPAGFVD MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR |
branched-chain amino acid biosynthetic process cellular response to leukemia inhibitory factor isoleucine catabolic process leucine biosynthetic process lipid metabolic process regulation of hormone levels valine biosynthetic process | mitochondrial matrix; mitochondrion; nucleoplasm | branched-chain-amino-acid transaminase activity L-isoleucine transaminase activity L-leucine transaminase activity L-leucine:2-oxoglutarate aminotransferase activity L-valine transaminase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Amino-acid biosynthesis Aminotransferase Branched-chain amino acid biosynthesis Disease variant Lipid metabolism Mitochondrion Pyridoxal phosphate Reference proteome Transferase Transit peptide | MAAAALGQIW | MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV | branched-chain amino acid biosynthetic process cellular response to leukemia inhibitory factor isoleucine catabolic process leucine biosynthetic process lipid metabolic process regulation of hormone levels valine biosynthetic process mitochondrial matrix; mitochondrion; nucleoplasm branched-chain-amino-acid transaminase activity L-isoleucine transaminase activity L-leucine transaminase activity L-leucine:2-oxoglutarate aminotransferase activity L-valine transaminase activity Homo sapiens 3D-structure Acetylation Alternative splicing Amino-acid biosynthesis Aminotransferase Branched-chain amino acid biosynthesis Disease variant Lipid metabolism Mitochondrion Pyridoxal phosphate Reference proteome Transferase Transit peptide MAAAALGQIW MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV |
cell adhesion | ficolin-1-rich granule membrane; plasma membrane; secretory granule membrane; tertiary granule membrane | carbohydrate binding sialic acid binding | Homo sapiens | 3D-structure Cell adhesion Disulfide bond Glycoprotein Immunoglobulin domain Lectin Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix | MLPLLLLPLL | MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK | cell adhesion ficolin-1-rich granule membrane; plasma membrane; secretory granule membrane; tertiary granule membrane carbohydrate binding sialic acid binding Homo sapiens 3D-structure Cell adhesion Disulfide bond Glycoprotein Immunoglobulin domain Lectin Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix MLPLLLLPLL MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK |
positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | nucleus; PcG protein complex; transcription regulator complex | cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator DNA-binding Metal-binding Nucleus Reference proteome Repeat Repressor Transcription Transcription regulation Zinc Zinc-finger | MASNEDFSIT | MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP | positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II nucleus; PcG protein complex; transcription regulator complex cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Activator DNA-binding Metal-binding Nucleus Reference proteome Repeat Repressor Transcription Transcription regulation Zinc Zinc-finger MASNEDFSIT MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP |
apoptotic process cell division establishment of chromosome localization G2/M transition of mitotic cell cycle mitotic cell cycle mitotic cytokinesis mitotic spindle assembly mitotic spindle assembly checkpoint signaling mitotic spindle midzone assembly negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA-templated transcription positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of cell population proliferation positive regulation of exit from mitosis positive regulation of mitotic cell cycle positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of mitotic cytokinesis positive regulation of mitotic sister chromatid separation protein phosphorylation protein-containing complex localization sensory perception of sound | centriole; chromosome passenger complex; chromosome, centromeric region; cytoplasm; cytoplasmic microtubule; cytosol; interphase microtubule organizing center; kinetochore; microtubule; microtubule cytoskeleton; midbody; nuclear chromosome; nucleoplasm; nucleus; protein-containing complex; spindle; spindle microtubule; survivin complex | cobalt ion binding cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process enzyme binding identical protein binding metal ion binding microtubule binding protein heterodimerization activity protein homodimerization activity protein-folding chaperone binding small GTPase binding tubulin binding zinc ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis Cell cycle Cell division Centromere Chromosome Chromosome partition Cytoplasm Cytoskeleton Host-virus interaction Kinetochore Metal-binding Microtubule Mitosis Nucleus Phosphoprotein Protease inhibitor Reference proteome Repressor Thiol protease inhibitor Transcription Transcription regulation Ubl conjugation Zinc | MGAPTLPPAW | MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD | apoptotic process cell division establishment of chromosome localization G2/M transition of mitotic cell cycle mitotic cell cycle mitotic cytokinesis mitotic spindle assembly mitotic spindle assembly checkpoint signaling mitotic spindle midzone assembly negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA-templated transcription positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of cell population proliferation positive regulation of exit from mitosis positive regulation of mitotic cell cycle positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of mitotic cytokinesis positive regulation of mitotic sister chromatid separation protein phosphorylation protein-containing complex localization sensory perception of sound centriole; chromosome passenger complex; chromosome, centromeric region; cytoplasm; cytoplasmic microtubule; cytosol; interphase microtubule organizing center; kinetochore; microtubule; microtubule cytoskeleton; midbody; nuclear chromosome; nucleoplasm; nucleus; protein-containing complex; spindle; spindle microtubule; survivin complex cobalt ion binding cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process enzyme binding identical protein binding metal ion binding microtubule binding protein heterodimerization activity protein homodimerization activity protein-folding chaperone binding small GTPase binding tubulin binding zinc ion binding Homo sapiens 3D-structure Acetylation Alternative splicing Apoptosis Cell cycle Cell division Centromere Chromosome Chromosome partition Cytoplasm Cytoskeleton Host-virus interaction Kinetochore Metal-binding Microtubule Mitosis Nucleus Phosphoprotein Protease inhibitor Reference proteome Repressor Thiol protease inhibitor Transcription Transcription regulation Ubl conjugation Zinc MGAPTLPPAW MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
positive regulation of viral entry into host cell protein autoprocessing proteolysis viral translation | extracellular exosome; extracellular region; nucleoplasm; plasma membrane | serine-type endopeptidase activity serine-type peptidase activity | Homo sapiens | 3D-structure Alternative splicing Autocatalytic cleavage Cell membrane Disulfide bond Glycoprotein Host-virus interaction Hydrolase Membrane Protease Reference proteome Secreted Serine protease Signal-anchor Transmembrane Transmembrane helix Zymogen | MALNSGSPPA | MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG | positive regulation of viral entry into host cell protein autoprocessing proteolysis viral translation extracellular exosome; extracellular region; nucleoplasm; plasma membrane serine-type endopeptidase activity serine-type peptidase activity Homo sapiens 3D-structure Alternative splicing Autocatalytic cleavage Cell membrane Disulfide bond Glycoprotein Host-virus interaction Hydrolase Membrane Protease Reference proteome Secreted Serine protease Signal-anchor Transmembrane Transmembrane helix Zymogen MALNSGSPPA MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG |
axonal fasciculation neuron cell-cell adhesion | axon; membrane; nuclear body; plasma membrane | identical protein binding | Homo sapiens | 3D-structure Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix | MSLLLSFYLL | MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA | axonal fasciculation neuron cell-cell adhesion axon; membrane; nuclear body; plasma membrane identical protein binding Homo sapiens 3D-structure Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix MSLLLSFYLL MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA |
intracellular protein transport organelle assembly organelle localization positive regulation of receptor localization to synapse positive regulation of T cell mediated cytotoxicity regulation of protein localization to plasma membrane vesicle docking vesicle fusion | azurophil granule; early endosome; early endosome membrane; endocytic vesicle; endomembrane system; endosome; extracellular exosome; immunological synapse; late endosome; lysosomal membrane; lysosome; perinuclear region of cytoplasm; plasma membrane; recycling endosome; SNARE complex; synaptic vesicle; tertiary granule; vesicle | chloride channel inhibitor activity SNAP receptor activity SNARE binding syntaxin binding | Homo sapiens | Acetylation Alternative splicing Coiled coil Direct protein sequencing Endosome Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MSYTPGVGGD | MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH | intracellular protein transport organelle assembly organelle localization positive regulation of receptor localization to synapse positive regulation of T cell mediated cytotoxicity regulation of protein localization to plasma membrane vesicle docking vesicle fusion azurophil granule; early endosome; early endosome membrane; endocytic vesicle; endomembrane system; endosome; extracellular exosome; immunological synapse; late endosome; lysosomal membrane; lysosome; perinuclear region of cytoplasm; plasma membrane; recycling endosome; SNARE complex; synaptic vesicle; tertiary granule; vesicle chloride channel inhibitor activity SNAP receptor activity SNARE binding syntaxin binding Homo sapiens Acetylation Alternative splicing Coiled coil Direct protein sequencing Endosome Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix MSYTPGVGGD MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH |
apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription by RNA polymerase II regulation of apoptotic process regulation of transcription by RNA polymerase II | cytosol; nucleoplasm; nucleus | chromatin binding chromatin DNA binding phosphoprotein binding protein homodimerization activity transcription coactivator activity | Homo sapiens | Activator Alternative splicing Apoptosis DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MDVRFYPAAA | MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIF | apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription by RNA polymerase II regulation of apoptotic process regulation of transcription by RNA polymerase II cytosol; nucleoplasm; nucleus chromatin binding chromatin DNA binding phosphoprotein binding protein homodimerization activity transcription coactivator activity Homo sapiens Activator Alternative splicing Apoptosis DNA-binding Nucleus Reference proteome Transcription Transcription regulation MDVRFYPAAA MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIF |
caudate nucleus development cerebral cortex development negative regulation of DNA-templated transcription putamen development regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific identical protein binding metal ion binding protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing Chromosomal rearrangement Disease variant DNA-binding Metal-binding Nucleus Reference proteome Repressor Transcription Transcription regulation Zinc Zinc-finger | MMQESATETI | MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE | caudate nucleus development cerebral cortex development negative regulation of DNA-templated transcription putamen development regulation of transcription by RNA polymerase II chromatin; nucleus DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific identical protein binding metal ion binding protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding Homo sapiens 3D-structure Alternative splicing Chromosomal rearrangement Disease variant DNA-binding Metal-binding Nucleus Reference proteome Repressor Transcription Transcription regulation Zinc Zinc-finger MMQESATETI MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE |
lactate transmembrane transport monocarboxylic acid transport protein catabolic process pyruvate catabolic process pyruvate transmembrane transport | apical plasma membrane; basolateral plasma membrane; lateral plasma membrane; membrane; nuclear membrane; plasma membrane; synapse | lactate:proton symporter activity monocarboxylic acid transmembrane transporter activity pyruvate transmembrane transporter activity RNA binding | Homo sapiens | Cell membrane Direct protein sequencing Membrane Phosphoprotein Reference proteome Symport Transmembrane Transmembrane helix Transport | MGGAVVDEGP | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV | lactate transmembrane transport monocarboxylic acid transport protein catabolic process pyruvate catabolic process pyruvate transmembrane transport apical plasma membrane; basolateral plasma membrane; lateral plasma membrane; membrane; nuclear membrane; plasma membrane; synapse lactate:proton symporter activity monocarboxylic acid transmembrane transporter activity pyruvate transmembrane transporter activity RNA binding Homo sapiens Cell membrane Direct protein sequencing Membrane Phosphoprotein Reference proteome Symport Transmembrane Transmembrane helix Transport MGGAVVDEGP MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV |
angiogenesis copper ion import copper ion transport establishment of localization in cell intracellular copper ion homeostasis plasma membrane copper ion transport protein complex oligomerization silver ion transmembrane transport vascular endothelial growth factor receptor-2 signaling pathway xenobiotic transport | apical plasma membrane; basolateral plasma membrane; early endosome membrane; intercalated disc; late endosome membrane; plasma membrane; recycling endosome membrane | copper ion binding copper ion transmembrane transporter activity identical protein binding silver ion transmembrane transporter activity xenobiotic transmembrane transporter activity | Homo sapiens | 3D-structure Cell membrane Copper Copper transport Disulfide bond Endosome Epilepsy Glycoprotein Ion transport Membrane Neurodegeneration Oxidation Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MDHSHHMGMS | MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH | angiogenesis copper ion import copper ion transport establishment of localization in cell intracellular copper ion homeostasis plasma membrane copper ion transport protein complex oligomerization silver ion transmembrane transport vascular endothelial growth factor receptor-2 signaling pathway xenobiotic transport apical plasma membrane; basolateral plasma membrane; early endosome membrane; intercalated disc; late endosome membrane; plasma membrane; recycling endosome membrane copper ion binding copper ion transmembrane transporter activity identical protein binding silver ion transmembrane transporter activity xenobiotic transmembrane transporter activity Homo sapiens 3D-structure Cell membrane Copper Copper transport Disulfide bond Endosome Epilepsy Glycoprotein Ion transport Membrane Neurodegeneration Oxidation Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport MDHSHHMGMS MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH |
copper ion import copper ion transport intracellular copper ion homeostasis regulation of copper ion transmembrane transport | late endosome membrane; lysosomal membrane; plasma membrane; recycling endosome | copper ion transmembrane transporter activity | Homo sapiens | Copper Copper transport Cytoplasmic vesicle Endosome Ion transport Lysosome Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation | MAMHFIFSDT | MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA | copper ion import copper ion transport intracellular copper ion homeostasis regulation of copper ion transmembrane transport late endosome membrane; lysosomal membrane; plasma membrane; recycling endosome copper ion transmembrane transporter activity Homo sapiens Copper Copper transport Cytoplasmic vesicle Endosome Ion transport Lysosome Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation MAMHFIFSDT MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA |
cell chemotaxis cell surface receptor signaling pathway cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis eosinophil chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response lymphocyte chemotaxis monocyte chemotaxis negative regulation of leukocyte tethering or rolling neutrophil chemotaxis positive regulation of cell-matrix adhesion positive regulation of ERK1 and ERK2 cascade | extracellular region; extracellular space | CCR chemokine receptor binding CCR10 chemokine receptor binding chemokine activity chemokine receptor binding hormone activity | Homo sapiens | Alternative splicing Chemotaxis Cytokine Disulfide bond Inflammatory response Reference proteome Secreted Signal | MNLWLLACLV | MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL | cell chemotaxis cell surface receptor signaling pathway cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis eosinophil chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response lymphocyte chemotaxis monocyte chemotaxis negative regulation of leukocyte tethering or rolling neutrophil chemotaxis positive regulation of cell-matrix adhesion positive regulation of ERK1 and ERK2 cascade extracellular region; extracellular space CCR chemokine receptor binding CCR10 chemokine receptor binding chemokine activity chemokine receptor binding hormone activity Homo sapiens Alternative splicing Chemotaxis Cytokine Disulfide bond Inflammatory response Reference proteome Secreted Signal MNLWLLACLV MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL |
rRNA transcription transcription by RNA polymerase I transmembrane receptor protein tyrosine kinase signaling pathway | chromosome; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm; RNA polymerase I complex; RNA polymerase I transcription regulator complex | RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chromosome DNA-directed RNA polymerase Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Ubl conjugation | MEEPQAGDAA | MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRHVPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQPV | rRNA transcription transcription by RNA polymerase I transmembrane receptor protein tyrosine kinase signaling pathway chromosome; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm; RNA polymerase I complex; RNA polymerase I transcription regulator complex RNA binding Homo sapiens 3D-structure Acetylation Alternative splicing Chromosome DNA-directed RNA polymerase Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Ubl conjugation MEEPQAGDAA MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRHVPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQPV |
female gamete generation homologous chromosome pairing at meiosis mismatch repair ovarian follicle development reciprocal meiotic recombination spermatogenesis | chromosome; nucleus; recombination nodule; synaptonemal complex | ATP binding ATP-dependent DNA damage sensor activity DNA binding double-stranded DNA binding mismatched DNA binding | Homo sapiens | ATP-binding Chromosome Disease variant DNA-binding Meiosis Nucleotide-binding Premature ovarian failure Reference proteome | MLRPEISSTS | MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE | female gamete generation homologous chromosome pairing at meiosis mismatch repair ovarian follicle development reciprocal meiotic recombination spermatogenesis chromosome; nucleus; recombination nodule; synaptonemal complex ATP binding ATP-dependent DNA damage sensor activity DNA binding double-stranded DNA binding mismatched DNA binding Homo sapiens ATP-binding Chromosome Disease variant DNA-binding Meiosis Nucleotide-binding Premature ovarian failure Reference proteome MLRPEISSTS MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE |
carbohydrate metabolic process glycosphingolipid biosynthetic process N-glycan processing oligosaccharide metabolic process protein glycosylation | Golgi membrane | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity | Homo sapiens | Alternative splicing Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MRYADPSANR | MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC | carbohydrate metabolic process glycosphingolipid biosynthetic process N-glycan processing oligosaccharide metabolic process protein glycosylation Golgi membrane alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity Homo sapiens Alternative splicing Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix MRYADPSANR MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC |
cell communication cell-cell signaling cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis eosinophil chemotaxis G protein-coupled receptor signaling pathway inflammatory response lymphocyte chemotaxis monocyte chemotaxis neutrophil chemotaxis positive regulation of ERK1 and ERK2 cascade | extracellular region; extracellular space | CCR chemokine receptor binding chemoattractant activity chemokine activity | Homo sapiens | 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Inflammatory response Reference proteome Secreted Signal | MKVSEAALSL | MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ | cell communication cell-cell signaling cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis eosinophil chemotaxis G protein-coupled receptor signaling pathway inflammatory response lymphocyte chemotaxis monocyte chemotaxis neutrophil chemotaxis positive regulation of ERK1 and ERK2 cascade extracellular region; extracellular space CCR chemokine receptor binding chemoattractant activity chemokine activity Homo sapiens 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Inflammatory response Reference proteome Secreted Signal MKVSEAALSL MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ |
proteolysis signal transduction | cell surface; cytoplasm; extracellular exosome; focal adhesion; synapse | calcium-dependent cysteine-type endopeptidase activity | Homo sapiens | 3D-structure Disease variant Hydrolase Protease Reference proteome Thiol protease | MFSCVKPYED | MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV | proteolysis signal transduction cell surface; cytoplasm; extracellular exosome; focal adhesion; synapse calcium-dependent cysteine-type endopeptidase activity Homo sapiens 3D-structure Disease variant Hydrolase Protease Reference proteome Thiol protease MFSCVKPYED MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV |
glycogen biosynthetic process | cytoplasm; cytosol | glycogenin glucosyltransferase activity glycosyltransferase activity metal ion binding UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity | Homo sapiens | 3D-structure Alternative splicing Glycogen biosynthesis Glycoprotein Manganese Metal-binding Phosphoprotein Reference proteome Transferase | MSETEFHHGA | MSETEFHHGAQAGLELLRSSNSPTSASQSAGMTVTDQAFVTLATNDIYCQGALVLGQSLRRHRLTRKLVVLITPQVSSLLRVILSKVFDEVIEVNLIDSADYIHLAFLKRPELGLTLTKLHCWTLTHYSKCVFLDADTLVLSNVDELFDRGEFSAAPDPGWPDCFNSGVFVFQPSLHTHKLLLQHAMEHGSFDGADQGLLNSFFRNWSTTDIHKHLPFIYNLSSNTMYTYSPAFKQFGSSAKVVHFLGSMKPWNYKYNPQSGSVLEQGSASSSQHQAAFLHLWWTVYQNNVLPLYKSVQAGEARASPGHTLCHSDVGGPCADSASGVGEPCENSTPSAGVPCANSPLGSNQPAQGLPEPTQIVDETLSLPEGRRSEDMIACPETETPAVITCDPLSQPSPQPADFTETETILQPANKVESVSSEETFEPSQELPAEALRDPSLQDALEVDLAVSVSQISIEEKVKELSPEEERRKWEEGRIDYMGKDAFARIQEKLDRFLQ | glycogen biosynthetic process cytoplasm; cytosol glycogenin glucosyltransferase activity glycosyltransferase activity metal ion binding UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Homo sapiens 3D-structure Alternative splicing Glycogen biosynthesis Glycoprotein Manganese Metal-binding Phosphoprotein Reference proteome Transferase MSETEFHHGA MSETEFHHGAQAGLELLRSSNSPTSASQSAGMTVTDQAFVTLATNDIYCQGALVLGQSLRRHRLTRKLVVLITPQVSSLLRVILSKVFDEVIEVNLIDSADYIHLAFLKRPELGLTLTKLHCWTLTHYSKCVFLDADTLVLSNVDELFDRGEFSAAPDPGWPDCFNSGVFVFQPSLHTHKLLLQHAMEHGSFDGADQGLLNSFFRNWSTTDIHKHLPFIYNLSSNTMYTYSPAFKQFGSSAKVVHFLGSMKPWNYKYNPQSGSVLEQGSASSSQHQAAFLHLWWTVYQNNVLPLYKSVQAGEARASPGHTLCHSDVGGPCADSASGVGEPCENSTPSAGVPCANSPLGSNQPAQGLPEPTQIVDETLSLPEGRRSEDMIACPETETPAVITCDPLSQPSPQPADFTETETILQPANKVESVSSEETFEPSQELPAEALRDPSLQDALEVDLAVSVSQISIEEKVKELSPEEERRKWEEGRIDYMGKDAFARIQEKLDRFLQ |
G protein-coupled receptor signaling pathway negative regulation of signal transduction positive regulation of GTPase activity regulation of G protein-coupled receptor signaling pathway visual perception | cytoplasm; membrane; plasma membrane | calmodulin binding GTPase activator activity GTPase activity | Homo sapiens | 3D-structure GTPase activation Lipoprotein Membrane Palmitate Phosphoprotein Reference proteome Signal transduction inhibitor | MCRTLAAFPT | MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT | G protein-coupled receptor signaling pathway negative regulation of signal transduction positive regulation of GTPase activity regulation of G protein-coupled receptor signaling pathway visual perception cytoplasm; membrane; plasma membrane calmodulin binding GTPase activator activity GTPase activity Homo sapiens 3D-structure GTPase activation Lipoprotein Membrane Palmitate Phosphoprotein Reference proteome Signal transduction inhibitor MCRTLAAFPT MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT |
endoplasmic reticulum to Golgi vesicle-mediated transport protein transport retrograde transport, endosome to Golgi vesicle docking involved in exocytosis vesicle targeting | apical dendrite; basal dendrite; cytoplasm; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; endosome; Golgi apparatus; Golgi membrane; mitochondrion; neuronal cell body; plasma membrane; SNARE complex; transport vesicle | cadherin binding protein-cysteine S-palmitoyltransferase activity SNAP receptor activity | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle ER-Golgi transport Golgi apparatus Lipoprotein Membrane Methylation Palmitate Phosphoprotein Prenylation Protein transport Reference proteome Transferase Transport | MKLYSLSVLY | MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM | endoplasmic reticulum to Golgi vesicle-mediated transport protein transport retrograde transport, endosome to Golgi vesicle docking involved in exocytosis vesicle targeting apical dendrite; basal dendrite; cytoplasm; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; endosome; Golgi apparatus; Golgi membrane; mitochondrion; neuronal cell body; plasma membrane; SNARE complex; transport vesicle cadherin binding protein-cysteine S-palmitoyltransferase activity SNAP receptor activity Homo sapiens 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle ER-Golgi transport Golgi apparatus Lipoprotein Membrane Methylation Palmitate Phosphoprotein Prenylation Protein transport Reference proteome Transferase Transport MKLYSLSVLY MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM |
anatomical structure morphogenesis regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | DNA-binding Homeobox Nucleus Reference proteome | MAAAAGGAAS | MAAAAGGAASRRGAGRPCPFSIEHILSSLPERSLPARAACPPQPAGRQSPAKPEEPGAPEAAPCACCCCCGPRAAPCGPPEAAAGLGARLAWPLRLGPAVPLSLGAPAGGSGALPGAVGPGSQRRTRRHRTIFSEEQLQALEALFVQNQYPDVSTRERLAGRIRLREERVEVWFKNRRAKWRHQKRASASARLLPGVKKSPKGSC | anatomical structure morphogenesis regulation of transcription by RNA polymerase II chromatin; nucleus DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens DNA-binding Homeobox Nucleus Reference proteome MAAAAGGAAS MAAAAGGAASRRGAGRPCPFSIEHILSSLPERSLPARAACPPQPAGRQSPAKPEEPGAPEAAPCACCCCCGPRAAPCGPPEAAAGLGARLAWPLRLGPAVPLSLGAPAGGSGALPGAVGPGSQRRTRRHRTIFSEEQLQALEALFVQNQYPDVSTRERLAGRIRLREERVEVWFKNRRAKWRHQKRASASARLLPGVKKSPKGSC |
cellular response to insulin stimulus cellular response to sterol cholesterol biosynthetic process cholesterol homeostasis cranial suture morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of cargo loading into COPII-coated vesicle negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of protein exit from endoplasmic reticulum negative regulation of steroid biosynthetic process roof of mouth development SREBP signaling pathway SREBP-SCAP complex retention in endoplasmic reticulum triglyceride metabolic process | endoplasmic reticulum; endoplasmic reticulum membrane; SREBP-SCAP-Insig complex | oxysterol binding protein sequestering activity | Homo sapiens | 3D-structure Alternative splicing Cholesterol metabolism Direct protein sequencing Endoplasmic reticulum Isopeptide bond Lipid metabolism Lipid-binding Membrane Phosphoprotein Reference proteome Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix Ubl conjugation | MPRLHDHFWS | MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMINVSVSGPSLLAAHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHHRLLQRSLVLFSVGVVLALVLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD | cellular response to insulin stimulus cellular response to sterol cholesterol biosynthetic process cholesterol homeostasis cranial suture morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of cargo loading into COPII-coated vesicle negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of protein exit from endoplasmic reticulum negative regulation of steroid biosynthetic process roof of mouth development SREBP signaling pathway SREBP-SCAP complex retention in endoplasmic reticulum triglyceride metabolic process endoplasmic reticulum; endoplasmic reticulum membrane; SREBP-SCAP-Insig complex oxysterol binding protein sequestering activity Homo sapiens 3D-structure Alternative splicing Cholesterol metabolism Direct protein sequencing Endoplasmic reticulum Isopeptide bond Lipid metabolism Lipid-binding Membrane Phosphoprotein Reference proteome Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix Ubl conjugation MPRLHDHFWS MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMINVSVSGPSLLAAHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHHRLLQRSLVLFSVGVVLALVLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD |
mRNA transport nucleocytoplasmic transport protein export from nucleus | cytosol; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm; nucleus | metal ion binding nuclear export signal receptor activity RNA binding | Homo sapiens | 3D-structure Alternative splicing Glycoprotein Membrane Metal-binding mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Reference proteome Repeat Translocation Transport Zinc Zinc-finger | MAICQFFLQG | MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGKIPLKPPPLELLNV | mRNA transport nucleocytoplasmic transport protein export from nucleus cytosol; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm; nucleus metal ion binding nuclear export signal receptor activity RNA binding Homo sapiens 3D-structure Alternative splicing Glycoprotein Membrane Metal-binding mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Reference proteome Repeat Translocation Transport Zinc Zinc-finger MAICQFFLQG MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGKIPLKPPPLELLNV |
actin cytoskeleton organization Arp2/3 complex-mediated actin nucleation cell migration regulation of actin filament polymerization | actin cytoskeleton; Arp2/3 protein complex; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; focal adhesion; lamellipodium; nucleus; secretory granule lumen; site of double-strand break | actin binding structural constituent of cytoskeleton | Homo sapiens | 3D-structure Acetylation Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Nucleus Reference proteome Ubl conjugation | MSKNTVSSAR | MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV | actin cytoskeleton organization Arp2/3 complex-mediated actin nucleation cell migration regulation of actin filament polymerization actin cytoskeleton; Arp2/3 protein complex; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; focal adhesion; lamellipodium; nucleus; secretory granule lumen; site of double-strand break actin binding structural constituent of cytoskeleton Homo sapiens 3D-structure Acetylation Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Nucleus Reference proteome Ubl conjugation MSKNTVSSAR MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV |
recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter | cytosol; nuclear speck; nucleoplasm; nucleus; RNA polymerase II, core complex | nucleotide binding translation initiation factor binding | Homo sapiens | 3D-structure DNA-directed RNA polymerase Nucleus Reference proteome Transcription | MAAGGSDPRA | MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter cytosol; nuclear speck; nucleoplasm; nucleus; RNA polymerase II, core complex nucleotide binding translation initiation factor binding Homo sapiens 3D-structure DNA-directed RNA polymerase Nucleus Reference proteome Transcription MAAGGSDPRA MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY |
cellular response to ionizing radiation circadian regulation of gene expression circadian rhythm DNA damage checkpoint signaling negative regulation of DNA-templated transcription negative regulation of glucocorticoid receptor signaling pathway photoperiodism positive regulation of circadian rhythm positive regulation of DNA-templated transcription positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity proteasome-mediated ubiquitin-dependent protein catabolic process protein acetylation regulation of circadian rhythm regulation of DNA-templated transcription regulation of hair cycle regulation of insulin secretion regulation of transcription by RNA polymerase II regulation of type B pancreatic cell development response to redox state signal transduction spermatogenesis | chromatin; chromatoid body; chromosome; CLOCK-BMAL transcription complex; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus | chromatin DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding histone acetyltransferase activity protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | 3D-structure Activator Acyltransferase Biological rhythms Cytoplasm DNA damage DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Transferase Ubl conjugation | MLFTVSCSKM | MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQSQQQQQLSRHRTDSLPDPSKVQPQ | cellular response to ionizing radiation circadian regulation of gene expression circadian rhythm DNA damage checkpoint signaling negative regulation of DNA-templated transcription negative regulation of glucocorticoid receptor signaling pathway photoperiodism positive regulation of circadian rhythm positive regulation of DNA-templated transcription positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity proteasome-mediated ubiquitin-dependent protein catabolic process protein acetylation regulation of circadian rhythm regulation of DNA-templated transcription regulation of hair cycle regulation of insulin secretion regulation of transcription by RNA polymerase II regulation of type B pancreatic cell development response to redox state signal transduction spermatogenesis chromatin; chromatoid body; chromosome; CLOCK-BMAL transcription complex; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus chromatin DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding histone acetyltransferase activity protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens 3D-structure Activator Acyltransferase Biological rhythms Cytoplasm DNA damage DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Transferase Ubl conjugation MLFTVSCSKM MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQSQQQQQLSRHRTDSLPDPSKVQPQ |
axonogenesis cell differentiation DNA-templated transcription epithelial cell proliferation liver development lung development negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MATSGRLSFT | MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW | axonogenesis cell differentiation DNA-templated transcription epithelial cell proliferation liver development lung development negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Developmental protein DNA-binding Homeobox Nucleus Reference proteome MATSGRLSFT MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW |
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