Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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associative learning cellular response to nerve growth factor stimulus chemical synaptic transmission inflammatory response long-term memory negative regulation of heart rate neuropeptide signaling pathway positive regulation of action potential positive regulation of acute inflammatory response positive regulation of ... | axon; extracellular region; extracellular space; neuronal cell body; synapse | substance K receptor binding substance P receptor binding | Rattus norvegicus | Alternative splicing Amidation Cleavage on pair of basic residues Neuropeptide Neurotransmitter Reference proteome Secreted Signal | MKILVAVAVF | MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK | associative learning cellular response to nerve growth factor stimulus chemical synaptic transmission inflammatory response long-term memory negative regulation of heart rate neuropeptide signaling pathway positive regulation of action potential positive regulation of acute inflammatory response positive regulation of ... |
carbon catabolite activation of transcription from RNA polymerase II promoter regulation of carbohydrate metabolic process regulation of cellular respiration regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | CCAAT-binding factor complex; nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific | Saccharomyces cerevisiae | Acetylation Activator DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MSADETDAKF | MSADETDAKFHPLETDLQSDTAAATSTAAASRSPSLQEKPIEMPLDMGKAPSPRGEDQRVTNEEDLFLFNRLRASQNRVMDSLEPQQQSQYTSSSVSTMEPSADFTSFSAVTTLPPPPHQQQQQQQQQQQQQQLVVQAQYTQNQPNLQSDVLGTAIAEQPFYVNAKQYYRILKRRYARAKLEEKLRISRERKPYLHESRHKHAMRRPRGEGGRFLTAAEIKAMKSKKSGASDDPDDSHEDKKITTKIIQEQPHATSTAAAADKKT | carbon catabolite activation of transcription from RNA polymerase II promoter regulation of carbohydrate metabolic process regulation of cellular respiration regulation of DNA-templated transcription regulation of transcription by RNA polymerase II CCAAT-binding factor complex; nucleus DNA binding DNA-binding transcrip... |
DNA amplification DNA recombinase assembly double-strand break repair via break-induced replication double-strand break repair via homologous recombination double-strand break repair via single-strand annealing meiotic joint molecule formation mitochondrial DNA repair mitotic recombination postreplication repair telome... | mitochondrion; nuclear chromosome; nucleus | DNA strand exchange activity DNA/DNA annealing activity | Saccharomyces cerevisiae | Alternative initiation DNA damage DNA recombination DNA repair Nucleus Phosphoprotein Reference proteome | MNEIMDMDEK | MNEIMDMDEKKPVFGNHSEDIQTKLDKKLGPEYISKRVGFGTSRIAYIEGWRVINLANQIFGYNGWSTEVKSVVIDFLDERQGKFSIGCTAIVRVTLTSGTYREDIGYGTVENERRKPAAFERAKKSAVTDALKRSLRGFGNALGNCLYDKDFLAKIDKVKFDPPDFDENNLFRPTDEISESSRTNTLHENQEQQQYPNKRRQLTKVTNTNPDSTKNLVKIENTVSRGTPMMAAPAEANSKNSSNKDTDLKSLDASKQDQDDLLDDSLMFSDDFQDDDLINMGNTNSNVLTTEKDPVVAKQSPTASSNPEAEQITFVTAK... | DNA amplification DNA recombinase assembly double-strand break repair via break-induced replication double-strand break repair via homologous recombination double-strand break repair via single-strand annealing meiotic joint molecule formation mitochondrial DNA repair mitotic recombination postreplication repair telome... |
(1->3)-beta-D-glucan biosynthetic process actin cytoskeleton organization actin filament organization ascospore wall assembly budding cell bud growth cellular bud neck septin ring organization fungal-type cell wall biogenesis positive regulation of endocytosis positive regulation of mitotic actomyosin contractile ring ... | 1,3-beta-D-glucan synthase complex; cell periphery; cellular bud; cellular bud neck; cellular bud tip; cytosol; endoplasmic reticulum; endosome membrane; fungal-type cell wall; fungal-type vacuole membrane; Golgi apparatus; incipient cellular bud site; mating projection tip; membrane; mitochondrial outer membrane; mito... | G-protein beta-subunit binding GTP binding GTPase activity protein kinase binding | Saccharomyces cerevisiae | 3D-structure Acetylation Cell membrane Direct protein sequencing Endosome GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Peroxisome Prenylation Reference proteome | MSQQVGNSIR | MSQQVGNSIRRKLVIVGDGACGKTCLLIVFSKGQFPEVYVPTVFENYVADVEVDGRRVELALWDTAGQEDYDRLRPLSYPDSNVVLICFSIDLPDSLENVQEKWIAEVLHFCQGVPIILVGCKVDLRNDPQTIEQLRQEGQQPVTSQEGQSVADQIGATGYYECSAKTGYGVREVFEAATRASLMGKSKTNGKAKKNTTEKKKKKCVLL | (1->3)-beta-D-glucan biosynthetic process actin cytoskeleton organization actin filament organization ascospore wall assembly budding cell bud growth cellular bud neck septin ring organization fungal-type cell wall biogenesis positive regulation of endocytosis positive regulation of mitotic actomyosin contractile ring ... |
actin filament organization establishment of cell polarity fungal-type cell wall organization microtubule-based process signal transduction small GTPase mediated signal transduction | cell periphery; cytosol; membrane; plasma membrane | GTP binding GTPase activity protein kinase binding | Saccharomyces cerevisiae | Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Reference proteome | MSEKAVRRKL | MSEKAVRRKLVIIGDGACGKTSLLYVFTLGKFPEQYHPTVFENYVTDCRVDGIKVSLTLWDTAGQEEYERLRPFSYSKADIILIGFAVDNFESLINARTKWADEALRYCPDAPIVLVGLKKDLRQEAHFKENATDEMVPIEDAKQVARAIGAKKYMECSALTGEGVDDVFEVATRTSLLMKKEPGANCCIIL | actin filament organization establishment of cell polarity fungal-type cell wall organization microtubule-based process signal transduction small GTPase mediated signal transduction cell periphery; cytosol; membrane; plasma membrane GTP binding GTPase activity protein kinase binding Saccharomyces cerevisiae Cell membr... |
carbohydrate metabolic process establishment of mitotic spindle orientation filamentous growth fungal-type cell wall assembly intracellular signal transduction invasive growth in response to glucose limitation negative regulation of translation phosphorylation positive regulation of filamentous growth of a population o... | cellular bud neck septin ring; cytoplasm; mitochondrion; nuclear envelope lumen; nuclear membrane; nucleotide-activated protein kinase complex; nucleus; vacuolar membrane | AMP-activated protein kinase activity ATP binding guanyl-nucleotide exchange factor activity identical protein binding molecular function activator activity protein kinase activity protein serine kinase activity protein serine/threonine kinase activity | Saccharomyces cerevisiae | 3D-structure ATP-binding Carbohydrate metabolism Cytoplasm Direct protein sequencing Isopeptide bond Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MSSNNNTNTA | MSSNNNTNTAPANANSSHHHHHHHHHHHHHGHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLK... | carbohydrate metabolic process establishment of mitotic spindle orientation filamentous growth fungal-type cell wall assembly intracellular signal transduction invasive growth in response to glucose limitation negative regulation of translation phosphorylation positive regulation of filamentous growth of a population o... |
cell wall integrity MAPK cascade invasive growth in response to glucose limitation MAPK cascade pheromone response MAPK cascade phosphorylation pseudohyphal growth signal transduction involved in filamentous growth | cytoplasm; mating projection tip | ATP binding MAP kinase kinase activity protein serine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity | Saccharomyces cerevisiae | ATP-binding Kinase Nucleotide-binding Pheromone response Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MFQRKTLQRR | MFQRKTLQRRNLKGLNLNLHPDVGNNGQLQEKTETHQGQSRIEGHVMSNINAIQNNSNLFLRRGIKKKLTLDAFGDDQAISKPNTVVIQQPQNEPVLVLSSLSQSPCVSSSSSLSTPCIIDAYSNNFGLSPSSTNSTPSTIQGLSNIATPVENEHSISLPPLEESLSPAAADLKDTLSGTSNGNYIQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDH... | cell wall integrity MAPK cascade invasive growth in response to glucose limitation MAPK cascade pheromone response MAPK cascade phosphorylation pseudohyphal growth signal transduction involved in filamentous growth cytoplasm; mating projection tip ATP binding MAP kinase kinase activity protein serine kinase activity pr... |
dTMP biosynthetic process dTTP biosynthetic process methylation | cytosol; mitochondrion; nuclear periphery | thymidylate synthase activity | Saccharomyces cerevisiae | Direct protein sequencing Methyltransferase Nucleotide biosynthesis Nucleus Reference proteome Transferase | MTMDGKNKEE | MTMDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIILELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKYKTCDDDYTGQGIDQLKQVIHKLKTNPYDRRIIMSAWNPADFDKMALPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDMGLGVPFNIASYALLTRMIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDIDDFKLTDFEIEDYNPHPRIQMKMSV | dTMP biosynthetic process dTTP biosynthetic process methylation cytosol; mitochondrion; nuclear periphery thymidylate synthase activity Saccharomyces cerevisiae Direct protein sequencing Methyltransferase Nucleotide biosynthesis Nucleus Reference proteome Transferase MTMDGKNKEE MTMDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFA... |
cell budding cytoskeleton organization endocytosis karyogamy involved in conjugation with cellular fusion microautophagy phosphatidylinositol biosynthetic process positive regulation of Arp2/3 complex-mediated actin nucleation protein import into nucleus receptor-mediated endocytosis regulation of membrane tubulation r... | actin cortical patch; cellular bud; cellular bud neck; cellular bud tip; central plaque of spindle pole body; incipient cellular bud site; mating projection tip; myosin I complex; myosin V complex | calcium ion binding calcium-dependent protein binding enzyme regulator activity mitogen-activated protein kinase binding | Saccharomyces cerevisiae | 3D-structure Calcium Cytoplasm Cytoskeleton Direct protein sequencing Metal-binding Phosphoprotein Reference proteome Repeat | MSSNLTEEQI | MSSNLTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVNDLMNEIDVDGNHQIEFSEFLALMSRQLKSNDSEQELLEAFKVFDKNGDGLISAAELKHVLTSIGEKLTDAEVDDMLREVSDGSGEINIQQFAALLSK | cell budding cytoskeleton organization endocytosis karyogamy involved in conjugation with cellular fusion microautophagy phosphatidylinositol biosynthetic process positive regulation of Arp2/3 complex-mediated actin nucleation protein import into nucleus receptor-mediated endocytosis regulation of membrane tubulation r... |
DNA replication viral genome replication | host cell cytoplasm; host cell nucleus | ATP binding ATP hydrolysis activity DNA binding DNA helicase activity | Human papillomavirus type 18 | 3D-structure ATP-binding DNA replication DNA-binding Early protein Helicase Host nucleus Hydrolase Isopeptide bond Nucleotide-binding Phosphoprotein Reference proteome Ubl conjugation | MADPEGTDGE | MADPEGTDGEGTGCNGWFYVQAIVDKKTGDVISDDEDENATDTGSDMVDFIDTQGTFCEQAELETAQALFHAQEVHNDAQVLHVLKRKFAGGSTENSPLGERLEVDTELSPRLQEISLNSGQKKAKRRLFTISDSGYGCSEVEATQIQVTTNGEHGGNVCSGGSTEAIDNGGTEGNNSSVDGTSDNSNIENVNPQCTIAQLKDLLKVNNKQGAMLAVFKDTYGLSFTDLVRNFKSDKTTCTDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDCKWGVLILALLRYKCGKSRLTVAKGLSTLLHVPETCMLIQPPKLR... | DNA replication viral genome replication host cell cytoplasm; host cell nucleus ATP binding ATP hydrolysis activity DNA binding DNA helicase activity Human papillomavirus type 183D-structure ATP-binding DNA replication DNA-binding Early protein Helicase Host nucleus Hydrolase Isopeptide bond Nucleotide-binding Phosphop... |
antigen processing and presentation of peptide antigen autophagic cell death CD4-positive, alpha-beta T cell lineage commitment cell communication cellular response to starvation collagen catabolic process decidualization elastin catabolic process enkephalin processing hair follicle morphogenesis immune response kerati... | apical plasma membrane; chromaffin granule; collagen-containing extracellular matrix; cytoplasm; cytoplasmic vesicle; external side of plasma membrane; extracellular space; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; microvillus; multivesicular body; neuron projection; nucleolus; nucleus; perik... | aminopeptidase activity collagen binding cysteine-type carboxypeptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activity cysteine-type peptidase activity endopeptidase activity fibronectin binding histone binding kininogen binding peptide binding... | Mus musculus | Cell membrane Cytoplasmic vesicle Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Membrane Protease Reference proteome Secreted Signal Thiol protease Zymogen | MNLLLLLAVL | MNLLLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDN... | antigen processing and presentation of peptide antigen autophagic cell death CD4-positive, alpha-beta T cell lineage commitment cell communication cellular response to starvation collagen catabolic process decidualization elastin catabolic process enkephalin processing hair follicle morphogenesis immune response kerati... |
anterior/posterior pattern specification embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II | nuclear body; nucleoplasm | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MTMSSFLINS | MTMSSFLINSNYIEPKFPPFEEFAPHGGPGGGDGAVGGGPGYPRPQSAPHLPAPNPHAARQPPAYYAPRAREPSYPGGLYPAPAAACPYACRGASPGRPEQSPAPGAHPSPAPQPPVPLGHCAPGPTTPAVATGGSAPACPLLLADQGPAGPKGKEPVVYPWMKKIHVSAVNSSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNTASAPAGPPGKAQTHSPHHHPHPLPGASTPIPSSI | anterior/posterior pattern specification embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II nuclear body; nucleoplasm DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding seq... |
malate metabolic process NADH metabolic process NADP metabolic process protein homotetramerization pyruvate metabolic process regulation of NADP metabolic process response to hormone | cytoplasm; cytosol; mitochondrion | identical protein binding magnesium ion binding malate dehydrogenase (decarboxylating) (NADP+) activity malic enzyme activity manganese ion binding NAD binding NADP binding oxaloacetate decarboxylase activity | Mus musculus | Acetylation Cytoplasm Direct protein sequencing Metal-binding NADP Oxidoreductase Phosphoprotein Reference proteome | MEPRAPRRRH | MEPRAPRRRHTHQRGYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLLMDLQDRNEKLFYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAWPEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKDPLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKE... | malate metabolic process NADH metabolic process NADP metabolic process protein homotetramerization pyruvate metabolic process regulation of NADP metabolic process response to hormone cytoplasm; cytosol; mitochondrion identical protein binding magnesium ion binding malate dehydrogenase (decarboxylating) (NADP+) activity... |
apoptotic process cell cycle cellular detoxification cellular response to type II interferon negative regulation of apoptotic process negative regulation of innate immune response positive regulation of brown fat cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of cardio... | cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane | ATP binding manganese ion binding protein serine kinase activity protein serine/threonine kinase activator activity protein serine/threonine kinase activity ribosomal small subunit binding | Mus musculus | Alternative initiation Apoptosis ATP-binding Cell cycle Cell membrane Cytoplasm Kinase Magnesium Membrane Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proto-oncogene Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MLLSKINSLA | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK | apoptotic process cell cycle cellular detoxification cellular response to type II interferon negative regulation of apoptotic process negative regulation of innate immune response positive regulation of brown fat cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of cardio... |
cellular response to amino acid stimulus proteolysis | cytoplasm; dendrite; plasma membrane | calcium ion binding calcium-dependent cysteine-type endopeptidase activity | Oryctolagus cuniculus | Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Protease Reference proteome Repeat Thiol protease | QKLIRIRNPW | QKLIRIRNPWGEVEWTGRWNDNCPNWNTVDPEVRERLAERHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYVIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELRGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKNGDFCVRVFSEKKADYQAVDDEIEADLEEADVSEDDIDDGFRRLFAQLAGEDAEISAFELQNILRRVLAKRQDIKTDGLSIETCKIMVDMLDSDGTGKLGLKEFY... | cellular response to amino acid stimulus proteolysis cytoplasm; dendrite; plasma membrane calcium ion binding calcium-dependent cysteine-type endopeptidase activity Oryctolagus cuniculus Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Protease Reference proteome Repeat Thiol protease QKLIRIRNPW QKLIRIR... |
proteolysis regulation of catalytic activity self proteolysis | cytosol; plasma membrane | calcium ion binding calcium-dependent cysteine-type endopeptidase activity peptidase activity | Oryctolagus cuniculus | Autocatalytic cleavage Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Protease Reference proteome Repeat Thiol protease | RESGCSFVLA | RESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPRELVGQPALHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKRAGTQELDDQIQANLPDEQVLSAEEIDENFKALFRQLAGEDLEISVRELQTILNRITSKHKDLRTKGFSMESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLAIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA | proteolysis regulation of catalytic activity self proteolysis cytosol; plasma membrane calcium ion binding calcium-dependent cysteine-type endopeptidase activity peptidase activity Oryctolagus cuniculus Autocatalytic cleavage Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Protease Reference proteome R... |
carbohydrate metabolic process viral budding from plasma membrane | host cell plasma membrane; membrane; virion membrane | exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity metal ion binding | Influenza A virus | 3D-structure Calcium Disulfide bond Glycoprotein Glycosidase Host cell membrane Host membrane Hydrolase Membrane Metal-binding Signal-anchor Transmembrane Transmembrane helix Virion | MNPNQKIITI | MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQHECDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPKVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPVKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLAGSAQHVEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSG... | carbohydrate metabolic process viral budding from plasma membrane host cell plasma membrane; membrane; virion membrane exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity metal ion binding Influenza A virus 3D-structure Calcium Disulfide bond Glycoprotein Glycosid... |
protein complex oligomerization suppression by virus of host autophagy uncoating of virus virus-mediated pore formation in host cell membrane | extracellular region; host cell plasma membrane; plasma membrane; virion membrane | monoatomic ion channel activity proton transmembrane transporter activity | Influenza A virus | 3D-structure Alternative splicing Disulfide bond Glycoprotein Host cell membrane Host membrane Host-virus interaction Hydrogen ion transport Inhibition of host autophagy by virus Ion channel Ion transport Lipoprotein Membrane Palmitate Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Tr... | MSLLTEVETP | MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE | protein complex oligomerization suppression by virus of host autophagy uncoating of virus virus-mediated pore formation in host cell membrane extracellular region; host cell plasma membrane; plasma membrane; virion membrane monoatomic ion channel activity proton transmembrane transporter activity Influenza A virus 3D-s... |
axon choice point recognition axon regeneration localization regulation of growth tissue regeneration | cytoplasm; dendrite; filopodium membrane; growth cone membrane; perikaryon; plasma membrane; postsynaptic density | calmodulin binding lipid binding lysophosphatidic acid binding phosphatidylinositol phosphate binding phosphatidylserine binding | Bos taurus | Calmodulin-binding Cell membrane Cell projection Cytoplasm Developmental protein Differentiation Direct protein sequencing Growth regulation Lipoprotein Membrane Neurogenesis Palmitate Phosphoprotein Reference proteome Synapse | MLCCMRRTKQ | MLCCMRRTKQVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEANEKDEAAVAEGTEKKEGEGSTPAEAAPGAGPKPEEKTGKAGETPSEEKKGEGAPDAATEQAAPQAPAPSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATAPAAEDAAAMATAQPPTETAESSQAEEKIEAVDETKPKDSARQDEGKGEEREADQEHA | axon choice point recognition axon regeneration localization regulation of growth tissue regeneration cytoplasm; dendrite; filopodium membrane; growth cone membrane; perikaryon; plasma membrane; postsynaptic density calmodulin binding lipid binding lysophosphatidic acid binding phosphatidylinositol phosphate binding ph... |
astrocyte differentiation axon choice point recognition axon guidance axon regeneration cell fate commitment radial glial cell differentiation regulation of filopodium assembly regulation of growth regulation of postsynaptic specialization assembly tissue regeneration | axon; cell periphery; cytoplasm; dendrite; filopodium membrane; GABA-ergic synapse; growth cone membrane; perikaryon; plasma membrane; postsynaptic density; presynapse | calmodulin binding lysophosphatidic acid binding phosphatidylinositol phosphate binding phosphatidylserine binding | Mus musculus | 3D-structure Calmodulin-binding Cell membrane Cell projection Cytoplasm Developmental protein Differentiation Direct protein sequencing Growth regulation Lipoprotein Membrane Neurogenesis Palmitate Phosphoprotein Reference proteome Synapse | MLCCMRRTKQ | MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAATKAAQPPTETAESSQAEEEKDAVDEAKPKESARQDEGKEDPEADQEHA | astrocyte differentiation axon choice point recognition axon guidance axon regeneration cell fate commitment radial glial cell differentiation regulation of filopodium assembly regulation of growth regulation of postsynaptic specialization assembly tissue regeneration axon; cell periphery; cytoplasm; dendrite; filopodi... |
DNA amplification double-strand break repair via single-strand annealing, removal of nonhomologous ends meiotic mismatch repair mitotic recombination nucleotide-excision repair nucleotide-excision repair, DNA damage recognition removal of nonhomologous ends | endonuclease complex; nucleotide-excision repair factor 1 complex; nucleus | damaged DNA binding endonuclease activity single-stranded DNA binding | Saccharomyces cerevisiae | DNA damage DNA repair DNA-binding Endonuclease Hydrolase Nuclease Nucleus Reference proteome | MNNTDPTSFE | MNNTDPTSFESILAGVAKLRKEKSGADTTGSQSLEIDASKLQQQEPQTSRRINSNQVINAFNQQKPEEWTDSKATDDYNRKRPFRSTRPGKTVLVNTTQKENPLLNHLKSTNWRYVSSTGINMIYYDYLVRGRSVLFLTLTYHKLYVDYISRRMQPLSRNENNILIFIVDDNNSEDTLNDITKLCMFNGFTLLLAFNFEQAAKYIEYLNL | DNA amplification double-strand break repair via single-strand annealing, removal of nonhomologous ends meiotic mismatch repair mitotic recombination nucleotide-excision repair nucleotide-excision repair, DNA damage recognition removal of nonhomologous ends endonuclease complex; nucleotide-excision repair factor 1 comp... |
nucleotide-excision repair positive regulation of mitotic recombination regulation of mitotic recombination transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter | cytosol; nucleotide-excision repair factor 3 complex; nucleus; transcription factor TFIIH core complex; transcription factor TFIIH holo complex | 4 iron, 4 sulfur cluster binding 5'-3' DNA helicase activity ATP binding ATP hydrolysis activity ATP-dependent activity, acting on DNA damaged DNA binding DNA helicase activity metal ion binding | Saccharomyces cerevisiae | 3D-structure 4Fe-4S ATP-binding Direct protein sequencing DNA damage DNA repair DNA-binding Helicase Hydrolase Iron Iron-sulfur Metal-binding Nucleotide-binding Nucleus Reference proteome Transcription Transcription regulation | MKFYIDDLPV | MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEA... | nucleotide-excision repair positive regulation of mitotic recombination regulation of mitotic recombination transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter cytosol; nucleotide-excision repair factor 3 complex; nucleus; transcription factor TFIIH core complex; transcription fact... |
chromatin organization heterochromatin formation negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription transcription elongation-coupled chromatin remodeling | cytosol; nucleus | DNA binding DNA secondary structure binding histone binding histone chaperone activity | Saccharomyces cerevisiae | Acetylation Activator Coiled coil DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation | MSFLSKLSQI | MSFLSKLSQIRKSTTASKAQVQDPLPKKNDEEYSLLPKNYIRDEDPAVKRLKELRRQELLKNGALAKKSGVKRKRGTSSGSEKKKIERNDDDEGGLGIRFKRSIGASHAPLKPVVRKKPEPIKKMSFEELMKQAENNEKQPPKVKSSEPVTKERPHFNKPGFKSSKRPQKKASPGATLRGVSSGGNSIKSSDSPKPVKLNLPTNGFAQPNRRLKEKLESRKQKSRYQDDYDEEDNDMDDFIEDDEDEGYHSKSKHSNGPGYDRDEIWAMFNRGKKRSEYDYDELEDDDMEANEMEILEEEEMARKMARLEDKREEAWLKK... | chromatin organization heterochromatin formation negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription transcription elongation-coupled chromatin remodeling cytosol; nucleus DNA binding DNA secondary structure binding histone binding histone chaperone activity Saccharomyces... |
chromatin organization invasive growth in response to glucose limitation pseudohyphal growth regulation of transcription by RNA polymerase II transcription by RNA polymerase II | cytosol; nucleus; SAGA complex; SLIK (SAGA-like) complex | protein heterodimerization activity transcription coregulator activity | Saccharomyces cerevisiae | 3D-structure Activator Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MMDKHKYRVE | MMDKHKYRVEIQQMMFVSGEINDPPVETTSLIEDIVRGQVIEILLQSNKTAHLRGSRSILPEDVIFLIRHDKAKVNRLRTYLSWKDLRKNAKDQDASAGVASGTGNPGAGGEDDLKKAGGGEKDEKDGGNMMKVKKSQIKLPWELQFMFNEHPLENNDDNDDMDEDEREANIVTLKRLKMADDRTRNMTKEEYVHWSDCRQASFTFRKNKRFKDWSGISQLTEGKPHDDVIDILGFLTFEIVCSLTETALKIKQREQVLQTQKDKSQQSSQDNTNFEFASSTLHRKKRLFDGPENVINPLKPRHIEEAWRVLQTIDMRHR... | chromatin organization invasive growth in response to glucose limitation pseudohyphal growth regulation of transcription by RNA polymerase II transcription by RNA polymerase II cytosol; nucleus; SAGA complex; SLIK (SAGA-like) complex protein heterodimerization activity transcription coregulator activity Saccharomyces c... |
lipid catabolic process | extracellular region | calcium ion binding carboxylic ester hydrolase activity | Canis lupus familiaris | 3D-structure Calcium Direct protein sequencing Disulfide bond Glycoprotein Lipid degradation Lipid metabolism Metal-binding Reference proteome Secreted Signal | MVSIWTIALF | MVSIWTIALFLLGAAKAKEVCYEQIGCFSDAEPWAGTAIRPLKVLPWSPERIGTRFLLYTNKNPNNFQTLLPSDPSTIEASNFQTDKKTRFIIHGFIDKGEENWLLDMCKNMFKVEEVNCICVDWKKGSQTSYTQAANNVRVVGAQVAQMLSMLSANYSYSPSQVQLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEASFQGTPEEVRLDPTDADFVDVIHTDAAPLIPFLGFGTSQQMGHLDFFPNGGEEMPGCKKNALSQIVDLDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYRAFESNKCFPCPDQ... | lipid catabolic process extracellular region calcium ion binding carboxylic ester hydrolase activity Canis lupus familiaris 3D-structure Calcium Direct protein sequencing Disulfide bond Glycoprotein Lipid degradation Lipid metabolism Metal-binding Reference proteome Secreted Signal MVSIWTIALF MVSIWTIALFLLGAAKAKEVCYEQI... |
arachidonic acid secretion lipid catabolic process phospholipid metabolic process | extracellular region | calcium ion binding phospholipase A2 activity toxin activity | Protobothrops flavoviridis | Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Myotoxin Secreted Signal Toxin | MRTLWIMAVL | MRTLWIMAVLLVGVDGGLWQFENMIIKVVKKSGILSYSAYGCYCGWGGRGKPKDATDRCCFVHDCCYGKVTGCNPKLGKYTYSWNNGDIVCEGDGPCKEVCECDRAAAICFRDNLDTYDRNKYWRYPASNCQEDSEPC | arachidonic acid secretion lipid catabolic process phospholipid metabolic process extracellular region calcium ion binding phospholipase A2 activity toxin activity Protobothrops flavoviridis Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Myotoxin Secreted Si... |
adult walking behavior cell morphogenesis involved in neuron differentiation dermatan sulfate catabolic process ganglioside catabolic process glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process hyaluronan catabolic process lipid storage lysosome organization maintenance of location in cell myelin... | azurophil granule; beta-N-acetylhexosaminidase complex; cytosol; extracellular exosome; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; membrane | acetylglucosaminyltransferase activity beta-N-acetylhexosaminidase activity N-acetyl-beta-D-galactosaminidase activity protein heterodimerization activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Gangliosidosis Glycoprotein Glycosidase Hydrolase Lipid metabolism Lysosome Neurodegeneration Reference proteome Signal Zymogen | MTSSRLWFSL | MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLG... | adult walking behavior cell morphogenesis involved in neuron differentiation dermatan sulfate catabolic process ganglioside catabolic process glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process hyaluronan catabolic process lipid storage lysosome organization maintenance of location in cell myelin... |
acute-phase response animal organ regeneration defense response to bacterium immune system process liver development negative regulation of hydrogen peroxide catabolic process Notch signaling pathway response to bacterium response to cobalamin response to electrical stimulus response to glucocorticoid response to growt... | blood microparticle; extracellular space; haptoglobin-hemoglobin complex | antioxidant activity hemoglobin binding identical protein binding serine-type endopeptidase activity | Rattus norvegicus | Acute phase Alternative splicing Antibiotic Antimicrobial Antioxidant Direct protein sequencing Disulfide bond Glycoprotein Hemoglobin-binding Immunity Reference proteome Secreted Serine protease homolog Signal Sushi | MRALGAVVTL | MRALGAVVTLLLWGQLFAVELGNDATDIEDDSCPKPPEIANGYVEHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAPTLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGRMGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILNKHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDK... | acute-phase response animal organ regeneration defense response to bacterium immune system process liver development negative regulation of hydrogen peroxide catabolic process Notch signaling pathway response to bacterium response to cobalamin response to electrical stimulus response to glucocorticoid response to growt... |
blood coagulation fibrinolysis proteolysis tissue remodeling | extracellular space | endopeptidase activity serine-type endopeptidase activity signaling receptor binding | Sus scrofa | Blood coagulation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Fibrinolysis Glycoprotein Hemostasis Hydrolase Kringle Phosphoprotein Protease Reference proteome Repeat Secreted Serine protease Signal Tissue remodeling Zymogen | MDHKEVVLLL | MDHKEVVLLLLLFLKSGLGDSLDDYVNTQGAFLFSLSRKQVAARSVEECAAKCEAETNFICRAFQYHSKDQQCVVMAENSKTSPIARMRDVVLFEKRIYLSECKTGNGKNYRGTTSKTKSGVICQKWSVSSPHIPKYSPEKFPLAGLEENYCRNPDNDEKGPWCYTTDPETRFDYCDIPECEDECMHCSGEHYEGKISKTMSGIECQSWGSQSPHAHGYLPSKFPNKNLKMNYCRNPDGEPRPWCFTTDPNKRWEFCDIPRCTTPPPTSGPTYQCLKGRGENYRGTVSVTASGHTCQRWSAQSPHKHNRTPENFPCKNLE... | blood coagulation fibrinolysis proteolysis tissue remodeling extracellular space endopeptidase activity serine-type endopeptidase activity signaling receptor binding Sus scrofa Blood coagulation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Fibrinolysis Glycoprotein Hemostasis Hydrolase Kr... |
blood coagulation fibrinolysis proteolysis response to heat tissue remodeling | extracellular space | endopeptidase activity protein domain specific binding serine-type endopeptidase activity signaling receptor binding | Bos taurus | Blood coagulation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Fibrinolysis Glycoprotein Hemostasis Hydrolase Kringle Phosphoprotein Protease Reference proteome Repeat Secreted Serine protease Signal Tissue remodeling Zymogen | MLPASPKMEH | MLPASPKMEHKAVVFLLLLFLKSGLGDLLDDYVNTQGASLLSLSRKNLAGRSVEDCAAKCEEETDFVCRAFQYHSKEQQCVVMAENSKNTPVFRMRDVILYEKRIYLLECKTGNGQTYRGTTAETKSGVTCQKWSATSPHVPKFSPEKFPLAGLEENYCRNPDNDENGPWCYTTDPDKRYDYCDIPECEDKCMHCSGENYEGKIAKTMSGRDCQAWDSQSPHAHGYIPSKFPNKNLKMNYCRNPDGEPRPWCFTTDPQKRWEFCDIPRCTTPPPSSGPKYQCLKGTGKNYGGTVAVTESGHTCQRWSEQTPHKHNRTPEN... | blood coagulation fibrinolysis proteolysis response to heat tissue remodeling extracellular space endopeptidase activity protein domain specific binding serine-type endopeptidase activity signaling receptor binding Bos taurus Blood coagulation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond ... |
angiogenesis fibrinolysis negative regulation of fibrinolysis negative regulation of plasminogen activation plasminogen activation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of reactive oxygen species metabolic process positive regulation of smooth mus... | cell surface; external side of plasma membrane; extracellular space; protein complex involved in cell-matrix adhesion; serine protease inhibitor complex; serine-type endopeptidase complex | peptidase activity serine-type endopeptidase activity | Mus musculus | 3D-structure Disulfide bond EGF-like domain Hydrolase Kringle Phosphoprotein Plasminogen activation Protease Reference proteome Secreted Serine protease Signal Zymogen | MKVWLASLFL | MKVWLASLFLCALVVKNSEGGSVLGAPDESNCGCQNGGVCVSYKYFSRIRRCSCPRKFQGEHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKHNYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIRTSTGQCAQPSRSIQTICLPPRFTDAPFGSDCEITGF... | angiogenesis fibrinolysis negative regulation of fibrinolysis negative regulation of plasminogen activation plasminogen activation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of reactive oxygen species metabolic process positive regulation of smooth mus... |
regulation of systemic arterial blood pressure zymogen activation | extracellular exosome; nucleus; secretory granule | serine-type endopeptidase activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Serine protease Signal Zymogen | MWFLVLCLAL | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS | regulation of systemic arterial blood pressure zymogen activation extracellular exosome; nucleus; secretory granule serine-type endopeptidase activity Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Serine protease Signal Zymogen... |
proteolysis | extracellular region | metal ion binding serine-type endopeptidase activity | Parengyodontium album | 3D-structure Calcium Direct protein sequencing Disulfide bond Hydrolase Metal-binding Protease Serine protease Signal Zymogen | MRLSVLLSLL | MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGFAATLDENMVRVLRAHPDVEYIEQDAVVTINAAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTSILSTWIGG... | proteolysis extracellular region metal ion binding serine-type endopeptidase activity Parengyodontium album 3D-structure Calcium Direct protein sequencing Disulfide bond Hydrolase Metal-binding Protease Serine protease Signal Zymogen MRLSVLLSLL MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGF... |
antibiotic biosynthetic process response to antibiotic | periplasmic space | metal ion binding penicillin amidase activity | Escherichia coli | 3D-structure Antibiotic resistance Calcium Direct protein sequencing Hydrolase Metal-binding Periplasm Signal Zymogen | MKNRNRMIVN | MKNRNRMIVNCVTASLMYYWSLPALAEQSSSEIKIVRDEYGMPHIYANDTWHLFYGYGYVVAQDRLFQMEMARRSTQGTVAEVLGKDFVKFDKDIRRNYWPDAIRAQIAALSPEDMSILQGYADGMNAWIDKVNTNPETLLPKQFNTFGFTPKRWEPFDVAMIFVGTMANRFSDSTSEIDNLALLTALKDKYGVSQGMAVFNQLKWLVNPSAPTTIAVQESNYPLKFNQQNSQTAALLPRYDLPAPMLDRPAKGADGALLALTAGKNRETIAAQFAQGGANGLAGYPTTSNMWVIGKSKAQDAKAIMVNGPQFGWYAPAY... | antibiotic biosynthetic process response to antibiotic periplasmic space metal ion binding penicillin amidase activity Escherichia coli3D-structure Antibiotic resistance Calcium Direct protein sequencing Hydrolase Metal-binding Periplasm Signal Zymogen MKNRNRMIVN MKNRNRMIVNCVTASLMYYWSLPALAEQSSSEIKIVRDEYGMPHIYANDTWHLFYG... |
cell population proliferation epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation... | extracellular region; extracellular space; secretory granule | hormone activity prolactin receptor binding | Mus musculus | Disulfide bond Hormone Lactation Phosphoprotein Reference proteome Secreted Signal | MNSQGSAQKA | MNSQGSAQKAGTLLLLLISNLLFCQNVQPLPICSAGDCQTSLRELFDRVVILSHYIHTLYTDMFIEFDKQYVQDREFMVKVINDCPTSSLATPEDKEQALKVPPEVLLNLILSLVQSSSDPLFQLITGVGGIQEAPEYILSRAKEIEEQNKQLLEGVEKIISQAYPEAKGNGIYFVWSQLPSLQGVDEESKILSLRNTIRCLRRDSHKVDNFLKVLRCQIAHQNNC | cell population proliferation epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation... |
animal organ development cellular response to alkaline pH cellular response to insulin stimulus cellular response to thyroid hormone stimulus female pregnancy growth hormone receptor signaling pathway lung alveolus development neuroblast proliferation positive regulation of glucose transmembrane transport positive regu... | collagen-containing extracellular matrix; endoplasmic reticulum; extracellular region; extracellular space; growth hormone receptor complex; nucleus; plasma membrane; secretory granule; trans-Golgi network; vesicle | cytokine activity growth factor activity growth hormone receptor binding hormone activity metal ion binding prolactin receptor binding | Mus musculus | Disulfide bond Hormone Metal-binding Phosphoprotein Reference proteome Secreted Signal Zinc | MATDSRTSWL | MATDSRTSWLLTVSLLCLLWPQEASAFPAMPLSSLFSNAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRTDMELLRFSLLLIQSWLGPVQFLSRIFTNSLMFGTSDRVYEKLKDLEEGIQALMQELEDGSPRVGQILKQTYDKFDANMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF | animal organ development cellular response to alkaline pH cellular response to insulin stimulus cellular response to thyroid hormone stimulus female pregnancy growth hormone receptor signaling pathway lung alveolus development neuroblast proliferation positive regulation of glucose transmembrane transport positive regu... |
activation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway cell-cell signaling endothelial cell migration endothelial cell proliferation G protein-coupled receptor internalization leukocyte cell-cell adhes... | cytoplasm; extracellular region; extracellular space | hormone activity protein-containing complex binding signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal | MGFQKFSPFL | MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA | activation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway cell-cell signaling endothelial cell migration endothelial cell proliferation G protein-coupled receptor internalization leukocyte cell-cell adhes... |
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of appetite negative regulation of e... | cytoplasm; extracellular region; extracellular space; plasma membrane | glucagon receptor binding hormone activity identical protein binding receptor ligand activity | Rattus norvegicus | Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal | MKTVYIVAGL | MKTVYIVAGLFVMLVQGSWQHAPQDTEENARSFPASQTEPLEDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIAEELGRRHADGSFSDEMNTILDNLATRDFINWLIQTKITDKK | adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of appetite negative regulation of e... |
antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide chromatin organization defense response to Gram-negative bacterium defense response to Gram-positive bacterium innate immune response in mucosa killing of cells of another organism negative regulation of tumor necrosi... | CENP-A containing nucleosome; cytosol; extracellular space; nucleoplasm; nucleosome; nucleus | DNA binding lipopolysaccharide binding protein heterodimerization activity structural constituent of chromatin | Homo sapiens | 3D-structure Acetylation ADP-ribosylation Antibiotic Antimicrobial Chromosome Direct protein sequencing DNA-binding Glycoprotein Hydroxylation Isopeptide bond Methylation Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation | MPEPAKSAPA | MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK | antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide chromatin organization defense response to Gram-negative bacterium defense response to Gram-positive bacterium innate immune response in mucosa killing of cells of another organism negative regulation of tumor necrosi... |
acetyl-CoA biosynthetic process from pyruvate glycolytic process pyruvate catabolic process pyruvate metabolic process | cytoplasm; pyruvate dehydrogenase complex | acetyltransferase activity dihydrolipoyllysine-residue acetyltransferase activity lipoic acid binding | Escherichia coli | 3D-structure Acetylation Acyltransferase Direct protein sequencing Glycolysis Lipoyl Reference proteome Repeat Transferase | MAIEIKVPDI | MAIEIKVPDIGADEVEITEILVKVGDKVEAEQSLITVEGDKASMEVPSPQAGIVKEIKVSVGDKTQTGALIMIFDSADGAADAAPAQAEEKKEAAPAAAPAAAAAKDVNVPDIGSDEVEVTEILVKVGDKVEAEQSLITVEGDKASMEVPAPFAGTVKEIKVNVGDKVSTGSLIMVFEVAGEAGAAAPAAKQEAAPAAAPAPAAGVKEVNVPDIGGDEVEVTEVMVKVGDKVAAEQSLITVEGDKASMEVPAPFAGVVKELKVNVGDKVKTGSLIMIFEVEGAAPAAAPAKQEAAAPAPAAKAEAPAAAPAAKAEGKSEF... | acetyl-CoA biosynthetic process from pyruvate glycolytic process pyruvate catabolic process pyruvate metabolic process cytoplasm; pyruvate dehydrogenase complex acetyltransferase activity dihydrolipoyllysine-residue acetyltransferase activity lipoic acid binding Escherichia coli 3D-structure Acetylation Acyltransferase... |
arginine biosynthetic process via ornithine citrulline biosynthetic process DNA damage response | cytoplasm | amino acid binding metal ion binding ornithine carbamoyltransferase activity | Escherichia coli | Amino-acid biosynthesis Arginine biosynthesis Cytoplasm Direct protein sequencing Metal-binding Reference proteome Transferase Zinc | MSDLYKKHFL | MSDLYKKHFLKLLDFTPAQFTSLLTLAAQLKADKKNGKEVQKLTGKNIALIFEKDSTRTRCSFEVAAFDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQYAGVPVWNGLTNEFHPTQLLADLMTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLLAPKACWPEESLVAECSALAEKHGGKITLTEDVAAGVKGADFIYTDVWVSMGEAKEKWAERIALLRGYQVNAQMMALTDNPNVKFLHCLPAFHDDQTTLGKQMAKEFDLHGGMEVTDEVFESAASIVFDQAENR... | arginine biosynthetic process via ornithine citrulline biosynthetic process DNA damage response cytoplasm amino acid binding metal ion binding ornithine carbamoyltransferase activity Escherichia coli Amino-acid biosynthesis Arginine biosynthesis Cytoplasm Direct protein sequencing Metal-binding Reference proteome Trans... |
dUMP biosynthetic process dUTP catabolic process protein homotrimerization | cytosol; protein-containing complex | dUTP diphosphatase activity identical protein binding magnesium ion binding | Escherichia coli | 3D-structure Cytoplasm Direct protein sequencing Hydrolase Magnesium Metal-binding Nucleotide metabolism Reference proteome | MMKKIDVKIL | MMKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLNDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ | dUMP biosynthetic process dUTP catabolic process protein homotrimerization cytosol; protein-containing complex dUTP diphosphatase activity identical protein binding magnesium ion binding Escherichia coli 3D-structure Cytoplasm Direct protein sequencing Hydrolase Magnesium Metal-binding Nucleotide metabolism Reference p... |
intracellular iron ion homeostasis siderophore transmembrane transport | cell outer membrane; membrane; transmembrane transporter complex | iron ion binding protein domain specific binding siderophore uptake transmembrane transporter activity signaling receptor activity toxic substance binding virion binding | Escherichia coli | 3D-structure Cell outer membrane Direct protein sequencing Disulfide bond Ion transport Iron Iron transport Membrane Receptor Reference proteome Signal TonB box Transmembrane Transmembrane beta strand Transport | MARSKTAQPK | MARSKTAQPKHSLRKIAVVVATAVSGMSVYAQAAVEPKEDTITVTAAPAPQESAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFD... | intracellular iron ion homeostasis siderophore transmembrane transport cell outer membrane; membrane; transmembrane transporter complex iron ion binding protein domain specific binding siderophore uptake transmembrane transporter activity signaling receptor activity toxic substance binding virion binding Escherichia co... |
iron ion import across plasma membrane siderophore-dependent iron import into cell | ATP-binding cassette (ABC) transporter complex; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; plasma membrane | transmembrane transporter activity | Escherichia coli | 3D-structure Cell inner membrane Cell membrane Ion transport Iron Iron transport Membrane Reference proteome Transmembrane Transmembrane helix Transport | MSKRIALFPA | MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAAQAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLAIVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLL... | iron ion import across plasma membrane siderophore-dependent iron import into cell ATP-binding cassette (ABC) transporter complex; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; plasma membrane transmembrane transporter activity Escherichia coli 3D-structure Cell inner membrane Ce... |
bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent swimming motility chemotaxis positive chemotaxis | bacterial-type flagellum; bacterial-type flagellum basal body, C ring; bacterial-type flagellum rotor complex; plasma membrane | cytoskeletal motor activity | Escherichia coli | 3D-structure Bacterial flagellum Cell inner membrane Cell membrane Chemotaxis Flagellar rotation Membrane Reference proteome | MGDSILSQAE | MGDSILSQAEIDALLNGDSEVKDEPTASVSGESDIRPYDPNTQRRVVRERLQALEIINERFARHFRMGLFNLLRRSPDITVGAIRIQPYHEFARNLPVPTNLNLIHLKPLRGTGLVVFSPSLVFIAVDNLFGGDGRFPTKVEGREFTHTEQRVINRMLKLALEGYSDAWKAINPLEVEYVRSEMQVKFTNITTSPNDIVVNTPFHVEIGNLTGEFNICLPFSMIEPLRELLVNPPLENSRNEDQNWRDNLVRQVQHSQLELVANFADISLRLSQILKLNPGDVLPIEKPDRIIAHVDGVPVLTSQYGTLNGQYALRIEHL... | bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent swimming motility chemotaxis positive chemotaxis bacterial-type flagellum; bacterial-type flagellum basal body, C ring; bacterial-type flagellum rotor complex; plasma membrane cytoskeletal motor activity Escherichia coli 3D-structur... |
heme biosynthetic process protoporphyrinogen IX biosynthetic process tetrapyrrole biosynthetic process | cytoplasm; cytosol | hydroxymethylbilane synthase activity | Escherichia coli | 3D-structure Direct protein sequencing Porphyrin biosynthesis Reference proteome Transferase | MLDNVLRIAT | MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA | heme biosynthetic process protoporphyrinogen IX biosynthetic process tetrapyrrole biosynthetic process cytoplasm; cytosol hydroxymethylbilane synthase activity Escherichia coli 3D-structure Direct protein sequencing Porphyrin biosynthesis Reference proteome Transferase MLDNVLRIAT MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELV... |
histidine biosynthetic process | cytoplasm; cytosol | histidinol dehydrogenase activity manganese ion binding metal ion binding NAD binding zinc ion binding | Escherichia coli | 3D-structure Amino-acid biosynthesis Direct protein sequencing Histidine biosynthesis Metal-binding NAD Oxidoreductase Reference proteome Zinc | MSFNTIIDWN | MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEIS... | histidine biosynthetic process cytoplasm; cytosol histidinol dehydrogenase activity manganese ion binding metal ion binding NAD binding zinc ion binding Escherichia coli 3D-structure Amino-acid biosynthesis Direct protein sequencing Histidine biosynthesis Metal-binding NAD Oxidoreductase Reference proteome Zinc MSFNTII... |
maturation of SSU-rRNA response to antibiotic ribosomal small subunit assembly rRNA base methylation rRNA methylation rRNA processing | cytosol | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity double-stranded DNA binding mRNA binding ribosomal small subunit binding rRNA (adenine-N6,N6-)-dimethyltransferase activity | Escherichia coli | 3D-structure Antibiotic resistance Cytoplasm Direct protein sequencing Methyltransferase Reference proteome RNA-binding rRNA processing S-adenosyl-L-methionine Transferase | MNNRVHQGHL | MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES | maturation of SSU-rRNA response to antibiotic ribosomal small subunit assembly rRNA base methylation rRNA methylation rRNA processing cytosol 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity double-stranded DNA binding mRNA binding ribosomal small subunit binding rRNA (adenine-N6,N6-)-dimet... |
DNA damage response monoatomic ion transmembrane transport receptor-mediated virion attachment to host cell | cell outer membrane; pore complex | identical protein binding metal ion binding porin activity virus receptor activity | Escherichia coli | 3D-structure Cell outer membrane Direct protein sequencing Ion transport Magnesium Membrane Metal-binding Porin Reference proteome Signal Stress response Transmembrane Transmembrane beta strand Transport | MKVKVLSLLV | MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGEGFTSGVTNNGRDALRQNGDGVGGSITYDYEGFGIGGAISSSKRTDAQNTAAYIGNGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQSKGKNLGRGYDDEDILKYVD... | DNA damage response monoatomic ion transmembrane transport receptor-mediated virion attachment to host cell cell outer membrane; pore complex identical protein binding metal ion binding porin activity virus receptor activity Escherichia coli 3D-structure Cell outer membrane Direct protein sequencing Ion transport Magne... |
DNA damage response glycolytic process | cytosol | 6-phosphofructokinase activity ATP binding identical protein binding magnesium ion binding protein homodimerization activity tagatose-6-phosphate kinase activity | Escherichia coli | 3D-structure ATP-binding Glycolysis Kinase Magnesium Metal-binding Nucleotide-binding Potassium Reference proteome Transferase | MVRIYTLTLA | MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR | DNA damage response glycolytic process cytosol 6-phosphofructokinase activity ATP binding identical protein binding magnesium ion binding protein homodimerization activity tagatose-6-phosphate kinase activity Escherichia coli 3D-structure ATP-binding Glycolysis Kinase Magnesium Metal-binding Nucleotide-binding Potassiu... |
NADPH regeneration proton export across plasma membrane | plasma membrane | NAD(P)+ transhydrogenase (AB-specific) activity NAD(P)+ transhydrogenase activity NADP binding protein dimerization activity | Escherichia coli | 3D-structure Cell inner membrane Cell membrane Direct protein sequencing Membrane NAD NADP Nucleotide-binding Reference proteome Translocase Transmembrane Transmembrane helix | MRIGIPRERL | MRIGIPRERLTNETRVAATPKTVEQLLKLGFTVAVESGAGQLASFDDKAFVQAGAEIVEGNSVWQSEIILKVNAPLDDEIALLNPGTTLVSFIWPAQNPELMQKLAERNVTVMAMDSVPRISRAQSLDALSSMANIAGYRAIVEAAHEFGRFFTGQITAAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVKEQVQSMGAEFLELDFKEEAGSGDGYAKVMSDAFIKAEMELFAAQAKEVDIIVTTALIPGKPAPKLITREMVDSMKAGSVIVDLAAQNGGNCEYTVPGEIFTTENGVKVIGYTDLPGRLP... | NADPH regeneration proton export across plasma membrane plasma membrane NAD(P)+ transhydrogenase (AB-specific) activity NAD(P)+ transhydrogenase activity NADP binding protein dimerization activity Escherichia coli 3D-structure Cell inner membrane Cell membrane Direct protein sequencing Membrane NAD NADP Nucleotide-bind... |
L-proline biosynthetic process | cytosol | glutamate-5-semialdehyde dehydrogenase activity identical protein binding NADP binding | Escherichia coli | Amino-acid biosynthesis Cytoplasm Direct protein sequencing NADP Oxidoreductase Proline biosynthesis Reference proteome | MLEQMGIAAK | MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSEAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESVEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAAALAQLQAGPAKVVAVKAEEYDDEFLSLDLNV... | L-proline biosynthetic process cytosol glutamate-5-semialdehyde dehydrogenase activity identical protein binding NADP binding Escherichia coli Amino-acid biosynthesis Cytoplasm Direct protein sequencing NADP Oxidoreductase Proline biosynthesis Reference proteome MLEQMGIAAK MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNAN... |
translational termination | cytosol | translation release factor activity, codon specific | Escherichia coli | 3D-structure Cytoplasm Direct protein sequencing Methylation Protein biosynthesis Reference proteome Ribosomal frameshifting | MFEINPVNNR | MFEINPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYLRWAESRGFKTEIIEESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRTSGAGGQHVNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWG... | translational termination cytosol translation release factor activity, codon specific Escherichia coli 3D-structure Cytoplasm Direct protein sequencing Methylation Protein biosynthesis Reference proteome Ribosomal frameshifting MFEINPVNNR MFEINPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVS... |
DNA replication initiation DNA replication, synthesis of RNA primer DNA unwinding involved in DNA replication plasmid maintenance replication fork processing response to radiation | DnaB-DnaC-DnaT-PriA-PriB complex; pre-primosome complex; primosome complex | identical protein binding single-stranded DNA binding | Escherichia coli | 3D-structure Direct protein sequencing DNA replication DNA-binding Primosome Reference proteome | MTNRLVLSGT | MTNRLVLSGTVCRAPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD | DNA replication initiation DNA replication, synthesis of RNA primer DNA unwinding involved in DNA replication plasmid maintenance replication fork processing response to radiation DnaB-DnaC-DnaT-PriA-PriB complex; pre-primosome complex; primosome complex identical protein binding single-stranded DNA binding Escherichia... |
cellular response to amino acid stimulus chemotaxis detection of chemical stimulus positive regulation of post-translational protein modification protein homooligomerization regulation of chemotaxis signal complex assembly signal transduction | cell tip; methyl accepting chemotaxis protein complex; plasma membrane | identical protein binding protein histidine kinase binding protein homodimerization activity transmembrane signaling receptor activity | Escherichia coli | 3D-structure Cell inner membrane Cell membrane Chemotaxis Membrane Methylation Reference proteome Transducer Transmembrane Transmembrane helix | MINRIRVVTL | MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADN... | cellular response to amino acid stimulus chemotaxis detection of chemical stimulus positive regulation of post-translational protein modification protein homooligomerization regulation of chemotaxis signal complex assembly signal transduction cell tip; methyl accepting chemotaxis protein complex; plasma membrane identi... |
nucleotide catabolic process | outer membrane-bounded periplasmic space | 5'-nucleotidase activity metal ion binding nucleotide binding UDP-sugar diphosphatase activity XMP 5'-nucleosidase activity | Escherichia coli | 3D-structure Direct protein sequencing Disulfide bond Hydrolase Metal-binding Nucleotide-binding Periplasm Reference proteome Signal Zinc | MKLLQRGVAL | MKLLQRGVALALLTTFTLASETALAYEQDKTYKITVLHTNDHHGHFWRNEYGEYGLAAQKTLVDGIRKEVAAEGGSVLLLSGGDINTGVPESDLQDAEPDFRGMNLVGYDAMAIGNHEFDNPLTVLRQQEKWAKFPLLSANIYQKSTGERLFKPWALFKRQDLKIAVIGLTTDDTAKIGNPEYFTDIEFRKPADEAKLVIQELQQTEKPDIIIAATHMGHYDNGEHGSNAPGDVEMARALPAGSLAMIVGGHSQDPVCMAAENKKQVDYVPGTPCKPDQQNGIWIVQAHEWGKYVGRADFEFRNGEMKMVNYQLIPVNLK... | nucleotide catabolic process outer membrane-bounded periplasmic space 5'-nucleotidase activity metal ion binding nucleotide binding UDP-sugar diphosphatase activity XMP 5'-nucleosidase activity Escherichia coli 3D-structure Direct protein sequencing Disulfide bond Hydrolase Metal-binding Nucleotide-binding Periplasm Re... |
mitochondrial electron transport, ubiquinol to cytochrome c | mitochondrial respiratory chain complex III | 2 iron, 2 sulfur cluster binding metal ion binding oxidoreductase activity ubiquinol-cytochrome-c reductase activity | Neurospora crassa | 2Fe-2S Direct protein sequencing Disulfide bond Electron transport Iron Iron-sulfur Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport | MAPVSIVSRA | MAPVSIVSRAAMRAAAAPARAVRALTTSTALQGSSSSTFESPFKGESKAAKVPDFGKYMSKAPPSTNMLFSYFMVGTMGAITAAGAKSTIQEFLKNMSASADVLAMAKVEVDLNAIPEGKNVIIKWRGKPVFIRHRTPAEIEEANKVNVATLRDPETDADRVKKPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRKGPAPLNLEIPLYEFPEEGKLVIG | mitochondrial electron transport, ubiquinol to cytochrome c mitochondrial respiratory chain complex III 2 iron, 2 sulfur cluster binding metal ion binding oxidoreductase activity ubiquinol-cytochrome-c reductase activity Neurospora crassa 2Fe-2S Direct protein sequencing Disulfide bond Electron transport Iron Iron-sulf... |
calcium ion homeostasis chloride ion homeostasis hyperosmotic salinity response magnesium ion homeostasis positive regulation of gene expression positive regulation of oxygen metabolic process positive regulation of P-type sodium:potassium-exchanging transporter activity positive regulation of peptide hormone secretion... | cytosol; extracellular space | growth hormone receptor binding hormone activity metal ion binding | Oncorhynchus keta | Direct protein sequencing Disulfide bond Hormone Metal-binding Secreted Signal Zinc | MGQVFLLMPV | MGQVFLLMPVLLVSCFLSQGAAIENQRLFNIAVSRVQHLHLLAQKMFNDFDGTLLPDERRQLNKIFLLDFCNSDSIVSPVDKHETQKSSVLKLLHISFRLIESWEYPSQTLIISNSLMVRNANQISEKLSDLKVGINLLITGSQDGVLSLDDNDSQQLPPYGNYYQNLGGDGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL | calcium ion homeostasis chloride ion homeostasis hyperosmotic salinity response magnesium ion homeostasis positive regulation of gene expression positive regulation of oxygen metabolic process positive regulation of P-type sodium:potassium-exchanging transporter activity positive regulation of peptide hormone secretion... |
positive regulation of canonical NF-kappaB signal transduction | cytosol; extracellular space; nucleoplasm; nucleus; perinuclear region of cytoplasm | actin binding calcium ion binding calcium-dependent protein binding chemoattractant activity identical protein binding RAGE receptor binding transition metal ion binding | Mus musculus | Acetylation Calcium Cytoplasm Direct protein sequencing Metal-binding Nucleus Reference proteome Repeat Secreted | MARPLEEALD | MARPLEEALDVIVSTFHKYSGKEGDKFKLNKTELKELLTRELPSFLGKRTDEAAFQKVMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK | positive regulation of canonical NF-kappaB signal transduction cytosol; extracellular space; nucleoplasm; nucleus; perinuclear region of cytoplasm actin binding calcium ion binding calcium-dependent protein binding chemoattractant activity identical protein binding RAGE receptor binding transition metal ion binding Mus... |
lipid catabolic process malate metabolic process triglyceride metabolic process | extracellular region; intracellular membrane-bounded organelle; mitochondrion | lipid binding malate dehydrogenase activity triglyceride lipase activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lipid degradation Lipid metabolism Reference proteome Secreted Signal | MWLLLTMASL | MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQ... | lipid catabolic process malate metabolic process triglyceride metabolic process extracellular region; intracellular membrane-bounded organelle; mitochondrion lipid binding malate dehydrogenase activity triglyceride lipase activity Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disulfide bond G... |
arachidonic acid metabolic process aromatic compound catabolic process epoxide metabolic process response to organic cyclic compound response to toxic substance xenobiotic metabolic process | endoplasmic reticulum membrane | cis-stilbene-oxide hydrolase activity epoxide hydrolase activity oxysterol binding | Homo sapiens | Aromatic hydrocarbons catabolism Detoxification Direct protein sequencing Endoplasmic reticulum Hydrolase Lipid metabolism Membrane Methylation Microsome Reference proteome Transmembrane Transmembrane helix | MWLEILLTSV | MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVG... | arachidonic acid metabolic process aromatic compound catabolic process epoxide metabolic process response to organic cyclic compound response to toxic substance xenobiotic metabolic process endoplasmic reticulum membrane cis-stilbene-oxide hydrolase activity epoxide hydrolase activity oxysterol binding Homo sapiens Aro... |
cellular response to anoxia cellular response to phosphate starvation dephosphorylation | outer membrane-bounded periplasmic space | 4-phytase activity acid phosphatase activity GTPase activity inositol phosphate phosphatase activity nucleotidase activity sugar-phosphatase activity | Escherichia coli | 3D-structure Direct protein sequencing Disulfide bond Hydrolase Periplasm Reference proteome Signal | MKAILIPFLS | MKAILIPFLSLLIPLTPQSAFAQSEPELKLESVVIVSRHGVRAPTKATQLMQDVTPDAWPTWPVKLGWLTPRGGELIAYLGHYQRQRLVADGLLAKKGCPQSGQVAIIADVDERTRKTGEAFAAGLAPDCAITVHTQADTSSPDPLFNPLKTGVCQLDNANVTDAILSRAGGSIADFTGHRQTAFRELERVLNFPQSNLCLKREKQDESCSLTQALPSELKVSADNVSLTGAVSLASMLTEIFLLQQAQGMPEPGWGRITDSHQWNTLLSLHNAQFYLLQRTPEVARSRATPLLDLIKTALTPHPPQKQAYGVTLPTSVL... | cellular response to anoxia cellular response to phosphate starvation dephosphorylation outer membrane-bounded periplasmic space 4-phytase activity acid phosphatase activity GTPase activity inositol phosphate phosphatase activity nucleotidase activity sugar-phosphatase activity Escherichia coli 3D-structure Direct prot... |
cellulose catabolic process | extracellular region | carbohydrate binding cellulase activity | Dickeya dadantii ) | 3D-structure Carbohydrate metabolism Cellulose degradation Disulfide bond Glycosidase Hydrolase Polysaccharide degradation Reference proteome Secreted Signal | MPLSYLDKNP | MPLSYLDKNPVIDSKKHALRKKLFLSCAYFGLSLACLSSNAWASVEPLSVNGNKIYAGEKAKSFAGNSLFWSNNGWGGEKFYTADTVASLKKDWKSSIVRAAMGVQESGGYLQDPAGNKAKVERVVDAAIANDMYAIIGWHSHSAENNRSEAIRFFQEMARKYGNKPNVIYEIYNEPLQVSWSNTIKPYAEAVISAIRAIDPDNLIIVGTPSWSQNVDEASRDPINAKNIAYTLHFYAGTHGESLRNKARQALNNGIALFVTEWGTVNADGNGGVNQTETDAWVTFMRDNNISNANWALNDKNEGASTYYPDSKNLTESG... | cellulose catabolic process extracellular region carbohydrate binding cellulase activity Dickeya dadantii )3D-structure Carbohydrate metabolism Cellulose degradation Disulfide bond Glycosidase Hydrolase Polysaccharide degradation Reference proteome Secreted Signal MPLSYLDKNP MPLSYLDKNPVIDSKKHALRKKLFLSCAYFGLSLACLSSNAWA... |
fatty acid metabolic process | endoplasmic reticulum; Golgi apparatus | fatty-acyl-CoA binding | Bos taurus | 3D-structure Acetylation Direct protein sequencing Endoplasmic reticulum Golgi apparatus Hydroxylation Lipid-binding Phosphoprotein Reference proteome Transport | MSQAEFDKAA | MSQAEFDKAAEEVKHLKTKPADEEMLFIYSHYKQATVGDINTERPGMLDFKGKAKWDAWNELKGTSKEDAMKAYIDKVEELKKKYGI | fatty acid metabolic process endoplasmic reticulum; Golgi apparatus fatty-acyl-CoA binding Bos taurus 3D-structure Acetylation Direct protein sequencing Endoplasmic reticulum Golgi apparatus Hydroxylation Lipid-binding Phosphoprotein Reference proteome Transport MSQAEFDKAA MSQAEFDKAAEEVKHLKTKPADEEMLFIYSHYKQATVGDINTERPG... |
fatty acid metabolic process negative regulation of protein lipidation phosphatidylcholine acyl-chain remodeling positive regulation of CoA-transferase activity positive regulation of phospholipid transport | endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; Golgi apparatus; perinuclear endoplasmic reticulum; protein-lipid complex | benzodiazepine receptor binding fatty-acyl-CoA binding identical protein binding long-chain fatty acyl-CoA binding | Homo sapiens | 3D-structure Acetylation Alternative promoter usage Alternative splicing Direct protein sequencing Endoplasmic reticulum Golgi apparatus Hydroxylation Lipid-binding Phosphoprotein Reference proteome Transport | MSQAEFEKAA | MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI | fatty acid metabolic process negative regulation of protein lipidation phosphatidylcholine acyl-chain remodeling positive regulation of CoA-transferase activity positive regulation of phospholipid transport endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; Golgi apparatus; perinuclear endoplasm... |
proline transport short-chain fatty acid transport transmembrane transport | plasma membrane | L-proline transmembrane transporter activity proline:sodium symporter activity sodium ion binding | Escherichia coli | Amino-acid transport Cell inner membrane Cell membrane Direct protein sequencing Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport | MAISTPMLVT | MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIENVDMLKGLNFVAIISLMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNDHPALAGAVNQNAERVFIELAQI... | proline transport short-chain fatty acid transport transmembrane transport plasma membrane L-proline transmembrane transporter activity proline:sodium symporter activity sodium ion binding Escherichia coli Amino-acid transport Cell inner membrane Cell membrane Direct protein sequencing Ion transport Membrane Reference ... |
cytosolic valyl-tRNA aminoacylation positive regulation of translational fidelity valyl-tRNA aminoacylation | cytosol | aminoacyl-tRNA editing activity ATP binding magnesium ion binding valine-tRNA ligase activity | Escherichia coli | Aminoacyl-tRNA synthetase ATP-binding Coiled coil Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Protein biosynthesis Reference proteome | MEKTYNPQDI | MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKTADGKDYLVVATTRPETLLGDTGVAVNPEDPRYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAQVFDTKGNE... | cytosolic valyl-tRNA aminoacylation positive regulation of translational fidelity valyl-tRNA aminoacylation cytosol aminoacyl-tRNA editing activity ATP binding magnesium ion binding valine-tRNA ligase activity Escherichia coli Aminoacyl-tRNA synthetase ATP-binding Coiled coil Cytoplasm Direct protein sequencing Ligase ... |
acetylcholine catabolic process acetylcholine catabolic process in synaptic cleft chemical synaptic transmission choline catabolic process choline metabolic process | cytoplasm; extracellular space; plasma membrane; side of membrane; synapse; synaptic cleft | acetylcholinesterase activity cholinesterase activity protein homodimerization activity serine hydrolase activity sulfate binding | Drosophila melanogaster | 3D-structure Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Neurotransmitter degradation Reference proteome Serine esterase Signal Synapse | MAISCRQSRV | MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEI... | acetylcholine catabolic process acetylcholine catabolic process in synaptic cleft chemical synaptic transmission choline catabolic process choline metabolic process cytoplasm; extracellular space; plasma membrane; side of membrane; synapse; synaptic cleft acetylcholinesterase activity cholinesterase activity protein ho... |
mitochondrial electron transport, ubiquinol to cytochrome c | mitochondrial respiratory chain complex III | heme binding metal ion binding ubiquinol-cytochrome-c reductase activity | Neurospora crassa | Direct protein sequencing Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport | MLARTCLRST | MLARTCLRSTRTFASAKNGAFKFAKRSASTQSSGAAAESPLRLNIAAAAATAVAAGSIAWYYHLYGFASAMTPAEEGLHATKYPWVHEQWLKTFDHQALRRGFQVYREVCASCHSLSRVPYRALVGTILTVDEAKALAEENEYDTEPNDQGEIEKRPGKLSDYLPDPYKNDEAARFANNGALPPDLSLIVKARHGGCDYIFSLLTGYPDEPPAGASVGAGLNFNPYFPGTGIAMARVLYDGLVDYEDGTPASTSQMAKDVVEFLNWAAEPEMDDRKRMGMKVLVVTSVLFALSVYVKRYKWAWLKSRKIVYDPPKSPPPA... | mitochondrial electron transport, ubiquinol to cytochrome c mitochondrial respiratory chain complex III heme binding metal ion binding ubiquinol-cytochrome-c reductase activity Neurospora crassa Direct protein sequencing Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Refe... |
cellular respiration mitochondrial electron transport, ubiquinol to cytochrome c | cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex III; mitochondrion | heme binding metal ion binding ubiquinol-cytochrome-c reductase activity | Saccharomyces cerevisiae | 3D-structure Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport | MFSNLSKRWA | MFSNLSKRWAQRTLSKSFYSTATGAASKSGKLTQKLVTAGVAAAGITASTLLYADSLTAEAMTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSHTNEEVRNMAEEFEYDDEPDEQGNPKKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLIVKARHGGCDYIFSLLTGYPDEPPAGVALPPGSNYNPYFPGGSIAMARVLFDDMVEYEDGTPATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIILSSLYLLSIWVKKFKWAGIKTRKFVFNPPKPRK | cellular respiration mitochondrial electron transport, ubiquinol to cytochrome c cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex III; mitochondrion heme binding metal ion binding ubiquinol-cytochrome-c reductase activity Saccharomyces cerevisiae 3D-stru... |
collagen catabolic process digestion proteolysis response to caffeine response to nicotine response to nutrient | collagen-containing extracellular matrix; extracellular region; extracellular space | calcium ion binding serine-type endopeptidase activity | Mus musculus | Calcium Digestion Disulfide bond Hydrolase Metal-binding Protease Reference proteome Secreted Serine protease Signal Zymogen | MSALLILALV | MSALLILALVGAAVAFPVDDDDKIVGGYTCRESSVPYQVSLNAGYHFCGGSLINDQWVVSAAHCYKYRIQVRLGEHNINVLEGNEQFVDSAKIIRHPNYNSWTLDNDIMLIKLASPVTLNARVASVPLPSSCAPAGTQCLISGWGNTLSNGVNNPDLLQCVDAPVLPQADCEASYPGDITNNMICVGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCAQPDAPGVYTKVCNYVDWIQNTIADN | collagen catabolic process digestion proteolysis response to caffeine response to nicotine response to nutrient collagen-containing extracellular matrix; extracellular region; extracellular space calcium ion binding serine-type endopeptidase activity Mus musculus Calcium Digestion Disulfide bond Hydrolase Metal-binding... |
acetoacetic acid metabolic process melanin biosynthetic process from tyrosine melanin metabolic process melanocyte differentiation melanosome organization pigmentation positive regulation of melanin biosynthetic process | clathrin-coated endocytic vesicle membrane; cytoplasm; endosome membrane; intracellular vesicle; melanosome; melanosome membrane | identical protein binding metal ion binding protein homodimerization activity tyrosinase activity | Mus musculus | 3D-structure Albinism Copper Disease variant Disulfide bond Glycoprotein Melanin biosynthesis Membrane Metal-binding Monooxygenase Oxidoreductase Reference proteome Signal Transmembrane Transmembrane helix Zinc | MKSYNVLPLA | MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVG... | acetoacetic acid metabolic process melanin biosynthetic process from tyrosine melanin metabolic process melanocyte differentiation melanosome organization pigmentation positive regulation of melanin biosynthetic process clathrin-coated endocytic vesicle membrane; cytoplasm; endosome membrane; intracellular vesicle; mel... |
cellular response to hydrogen peroxide cellular response to hypoxia fatty acid transport intestinal absorption negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of fatty acid beta-oxidation response to vitamin B3 | apical cortex; cytosol; extracellular exosome; nucleoplasm; nucleus; peroxisomal matrix; protein-containing complex | antioxidant activity bile acid binding chromatin binding fatty acid binding heterocyclic compound binding long-chain fatty acid transporter activity oleic acid binding phospholipid binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Lipid-binding Phosphoprotein Reference proteome Transport | MSFSGKYQLQ | MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI | cellular response to hydrogen peroxide cellular response to hypoxia fatty acid transport intestinal absorption negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of fatty acid beta-oxidation response to vitamin B3 apical... |
adaptive immune response apoptotic cell clearance autophagy chemotaxis DNA recombination DNA repair inflammatory response innate immune response negative regulation of RNA polymerase II transcription preinitiation complex assembly neutrophil clearance positive regulation of DNA ligation positive regulation of toll-like... | condensed chromosome; endoplasmic reticulum-Golgi intermediate compartment; endosome; extracellular region; nucleus; plasma membrane | double-stranded DNA binding | Cricetulus griseus | 3D-structure Acetylation Adaptive immunity ADP-ribosylation Autophagy Cell membrane Chemotaxis Chromosome Cytoplasm Disulfide bond DNA damage DNA recombination DNA repair DNA-binding Endosome Immunity Inflammatory response Innate immunity Isopeptide bond Membrane Nucleus Oxidation Phosphoprotein Repeat Secreted | VNFSEFSKKC | VNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | adaptive immune response apoptotic cell clearance autophagy chemotaxis DNA recombination DNA repair inflammatory response innate immune response negative regulation of RNA polymerase II transcription preinitiation complex assembly neutrophil clearance positive regulation of DNA ligation positive regulation of toll-like... |
ADP biosynthetic process AMP metabolic process ATP metabolic process DNA replication initiation nucleotide metabolic process phosphorylation | cytoplasm; cytosol; mitochondrial intermembrane space; mitochondrion | adenylate kinase activity ATP binding | Saccharomyces cerevisiae | 3D-structure Acetylation ATP-binding Cytoplasm Direct protein sequencing Kinase Mitochondrion Nucleotide-binding Reference proteome Transferase | MSSSESIRMV | MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKD | ADP biosynthetic process AMP metabolic process ATP metabolic process DNA replication initiation nucleotide metabolic process phosphorylation cytoplasm; cytosol; mitochondrial intermembrane space; mitochondrion adenylate kinase activity ATP binding Saccharomyces cerevisiae 3D-structure Acetylation ATP-binding Cytoplasm... |
cellular response to organic substance cochlea development learning or memory locomotory behavior long-term memory metanephric collecting duct development metanephric connecting tubule development metanephric distal convoluted tubule development metanephric part of ureteric bud development regulation of long-term synap... | axon; calyx of Held; cuticular plate; cytoplasm; cytosol; dendrite; dendritic spine; GABA-ergic synapse; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; neuron projection; neuronal cell body; nucleus; postsynapse; postsynaptic cytosol; presynaptic cytosol; stereocilium; synapse; terminal bouton | calcium ion binding calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration vitamin D binding zinc ion binding | Rattus norvegicus | 3D-structure Acetylation Calcium Direct protein sequencing Metal-binding Reference proteome Repeat Vitamin D | MAESHLQSSL | MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELLQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQELDINNISTYKKNIMALSDGGKLYRTDLALILSAGDN | cellular response to organic substance cochlea development learning or memory locomotory behavior long-term memory metanephric collecting duct development metanephric connecting tubule development metanephric distal convoluted tubule development metanephric part of ureteric bud development regulation of long-term synap... |
photosynthesis photosynthesis, light reaction | plasma membrane light-harvesting complex; plasma membrane-derived chromatophore membrane | electron transfer activity heme binding iron ion binding | Blastochloris viridis | 3D-structure Direct protein sequencing Electron transport Heme Iron Lipoprotein Membrane Metal-binding Photosynthesis Reaction center Reference proteome Signal Transport | MKQLIVNSVA | MKQLIVNSVATVALASLVAGCFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEA... | photosynthesis photosynthesis, light reaction plasma membrane light-harvesting complex; plasma membrane-derived chromatophore membrane electron transfer activity heme binding iron ion binding Blastochloris viridis 3D-structure Direct protein sequencing Electron transport Heme Iron Lipoprotein Membrane Metal-binding Pho... |
lactate metabolic process NAD metabolic process pyruvate metabolic process | cytoplasm; cytosol; extracellular exosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; oxidoreductase complex | identical protein binding kinase binding L-lactate dehydrogenase activity NAD binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Disease variant Membrane Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Phosphoprotein Reference proteome | MATLKEKLIA | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKS... | lactate metabolic process NAD metabolic process pyruvate metabolic process cytoplasm; cytosol; extracellular exosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; oxidoreductase complex identical protein binding kinase binding L-lactate dehydrogenase activity NAD binding Homo sapiens 3D-structu... |
anterograde axonal transport axonal transport of mitochondrion axonogenesis cerebral cortex development hippocampus development intermediate filament organization intermediate filament polymerization or depolymerization locomotion microtubule cytoskeleton organization motor neuron apoptotic process negative regulation ... | axon; axon cytoplasm; cholinergic synapse; cytoplasm; cytosol; growth cone; intermediate filament; neurofilament; neuromuscular junction; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse | identical protein binding phospholipase binding protein domain specific binding protein-containing complex binding protein-macromolecule adaptor activity structural constituent of cytoskeleton structural constituent of postsynaptic intermediate filament cytoskeleton | Homo sapiens | Acetylation Cell projection Charcot-Marie-Tooth disease Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Intermediate filament Methylation Neurodegeneration Neuropathy Phosphoprotein Reference proteome Ubl conjugation | MSSFSYEPYY | MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIE... | anterograde axonal transport axonal transport of mitochondrion axonogenesis cerebral cortex development hippocampus development intermediate filament organization intermediate filament polymerization or depolymerization locomotion microtubule cytoskeleton organization motor neuron apoptotic process negative regulation ... |
neurofilament bundle assembly | axon; cytoplasm; intermediate filament; intermediate filament cytoskeleton; neurofibrillary tangle; neurofilament; postsynaptic intermediate filament cytoskeleton | microtubule binding structural constituent of cytoskeleton | Homo sapiens | Acetylation Alternative splicing Cell projection Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Glycoprotein Intermediate filament Methylation Phosphoprotein Reference proteome Repeat | MSYTLDSLGN | MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEY... | neurofilament bundle assembly axon; cytoplasm; intermediate filament; intermediate filament cytoskeleton; neurofibrillary tangle; neurofilament; postsynaptic intermediate filament cytoskeleton microtubule binding structural constituent of cytoskeleton Homo sapiens Acetylation Alternative splicing Cell projection Coiled... |
embryonic hemopoiesis hormone biosynthetic process hydrogen peroxide catabolic process response to oxidative stress thyroid hormone generation | cell surface; extracellular space; plasma membrane | calcium ion binding heme binding iodide peroxidase activity peroxidase activity | Homo sapiens | Alternative splicing Calcium Congenital hypothyroidism Disease variant Disulfide bond EGF-like domain Glycoprotein Heme Hydrogen peroxide Iron Membrane Metal-binding Oxidoreductase Peroxidase Reference proteome Signal Sushi Thyroid hormones biosynthesis Transmembrane Transmembrane helix | MRALAVLSVT | MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGL... | embryonic hemopoiesis hormone biosynthetic process hydrogen peroxide catabolic process response to oxidative stress thyroid hormone generation cell surface; extracellular space; plasma membrane calcium ion binding heme binding iodide peroxidase activity peroxidase activity Homo sapiens Alternative splicing Calcium Cong... |
blood coagulation blood coagulation, common pathway female pregnancy negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation proteolysis response to cAMP response to lipopolysaccharide response to X-ray zymogen activation | apicolateral plasma membrane; cell surface; external side of plasma membrane; extracellular space; plasma membrane; serine-type endopeptidase complex; vacuolar membrane | calcium ion binding signaling receptor activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond EGF-like domain Glycoprotein Hemolytic uremic syndrome Hemostasis Hydroxylation Membrane Proteoglycan Receptor Reference proteome Repeat Signal Thrombophilia Transmembrane Transmembrane helix | MLGVLVLGAL | MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQ... | blood coagulation blood coagulation, common pathway female pregnancy negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation proteolysis response to cAMP response to lipopolysaccharide response to X-ray zymogen activation apicolateral plasma membrane; cell... |
canonical glycolysis flagellated sperm motility gluconeogenesis glycolytic process phosphorylation | cytosol; extracellular exosome; nucleus; sperm fibrous sheath | ADP binding ATP binding phosphoglycerate kinase activity | Homo sapiens | Acetylation ATP-binding Cytoplasm Glycolysis Kinase Nucleotide-binding Phosphoprotein Reference proteome Transferase | MSLSKKLTLD | MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVLMSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLENLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGMAYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGKATVASGISPGWMGLDCGPES... | canonical glycolysis flagellated sperm motility gluconeogenesis glycolytic process phosphorylation cytosol; extracellular exosome; nucleus; sperm fibrous sheath ADP binding ATP binding phosphoglycerate kinase activity Homo sapiens Acetylation ATP-binding Cytoplasm Glycolysis Kinase Nucleotide-binding Phosphoprotein Ref... |
protein import into mitochondrial matrix protein insertion into mitochondrial inner membrane protein insertion into mitochondrial outer membrane protein targeting to mitochondrion | mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion | mitochondrion targeting sequence binding protein-transporting ATPase activity | Saccharomyces cerevisiae | 3D-structure Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome Repeat TPR repeat Transmembrane Transmembrane helix | MKSFITRNKT | MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNN... | protein import into mitochondrial matrix protein insertion into mitochondrial inner membrane protein insertion into mitochondrial outer membrane protein targeting to mitochondrion mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion mitochondrion targeting sequence binding prote... |
anatomical structure development bone development cellular response to growth factor stimulus lung development negative regulation of angiogenesis negative regulation of endothelial cell proliferation pigmentation positive regulation of endothelial cell migration regulation of cell morphogenesis regulation of cell popu... | basement membrane; cell surface; collagen-containing extracellular matrix; extracellular matrix; extracellular space; glutamatergic synapse; intracellular membrane-bounded organelle; nuclear matrix; platelet alpha granule; platelet alpha granule membrane; synapse; vesicle | calcium ion binding collagen binding extracellular matrix binding | Mus musculus | Basement membrane Calcium Copper Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Metal-binding Reference proteome Secreted Signal | MRAWIFFLLC | MRAWIFFLLCLAGRALAAPQQTEVAEEIVEEETVVEETGVPVGANPVQVEMGEFEDGAEETVEEVVADNPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI | anatomical structure development bone development cellular response to growth factor stimulus lung development negative regulation of angiogenesis negative regulation of endothelial cell proliferation pigmentation positive regulation of endothelial cell migration regulation of cell morphogenesis regulation of cell popu... |
positive regulation of release of sequestered calcium ion into cytosol positive regulation of store-operated calcium channel activity protein polymerization regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of store-operated calcium entry sarcomere organization | mitochondrial matrix; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; sarcoplasmic reticulum membrane | calcium ion binding ion binding magnesium ion binding metal ion binding potassium ion binding protein homodimerization activity | Oryctolagus cuniculus | 3D-structure Calcium Direct protein sequencing Endoplasmic reticulum Glycoprotein Membrane Metal-binding Mitochondrion Muscle protein Phosphoprotein Reference proteome Sarcoplasmic reticulum Signal | MNAADRMGAR | MNAADRMGARVALLLLLVLGSPQSGVHGEEGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEEDSIYVFKEDEVIEYDGEFSADTLVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKNKDSEHYKAFKEAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGYEFLEILKSVAQDNTDNPDLSIIWIDPDDF... | positive regulation of release of sequestered calcium ion into cytosol positive regulation of store-operated calcium channel activity protein polymerization regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of store-operated calcium entry sarcomere organization mit... |
DNA repair regulation of endodeoxyribonuclease activity regulation of endoribonuclease activity | cytoplasm; nucleolus; nucleoplasm | identical protein binding RNA binding | Xenopus laevis | 3D-structure Chaperone Cytoplasm Nucleus Phosphoprotein Reference proteome Repeat RNA-binding | MEDSMDMDNI | MEDSMDMDNIAPLRPQNFLFGCELKADKKEYSFKVEDDENEHQLSLRTVSLGASAKDELHVVEAEGINYEGKTIKIALASLKPSVQPTVSLGGFEITPPVILRLKSGSGPVYVSGQHLVALEDLESSDDEDEEHEPSPKNAKRIAPDSASKVPRKKTRLEEEEEDSDEDDDDDEDDDDEDDDEEEEETPVKKTDSTKSKAAQKLNHNGKASALSTTQKTPKTPEQKGKQDTKPQTPKTPKTPLSSEEIKAKMQTYLEKGNVLPKVEVKFANYVKNCFRTENQKVIEDLWKWRQSLKDGK | DNA repair regulation of endodeoxyribonuclease activity regulation of endoribonuclease activity cytoplasm; nucleolus; nucleoplasm identical protein binding RNA binding Xenopus laevis 3D-structure Chaperone Cytoplasm Nucleus Phosphoprotein Reference proteome Repeat RNA-binding MEDSMDMDNI MEDSMDMDNIAPLRPQNFLFGCELKADKKEYS... |
blood coagulation fibrinolysis | extracellular space | calcium ion binding | Bos taurus | Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Fibrinolysis Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Reference proteome Repeat Secreted Signal Zymogen | MRVLGGRTGT | MRVLGGRTGTLLACLALVLPVLEANFLSRQHASQVLIRRRRANTLLEETKKGNLERECIEELCNKEEAREIFENNPETEYFYPKYLGCLGSFRAGLFTAARLSTNAYPDLRSCVNAISDQCNPLPCNEDGFMTCKDGQATFTCICKSGWQGEKCESDINECKDPVNINGGCSQICENTPGSYHCSCKNGFVMLSNKKDCKDVDECVLKPSICGTAVCKNIPGDFECECAEGYKYNPVSKSCDDVDECAENLCAQLCVNYPGGYSCYCDGKKGFKLAQDQKSCEAVPVCLPLDLDKNYELLYLAEQFVGVVLYLKFRLPET... | blood coagulation fibrinolysis extracellular space calcium ion binding Bos taurus Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Fibrinolysis Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Reference proteome Repeat Secreted Signal ... |
blood coagulation fibrinolysis | blood microparticle; endoplasmic reticulum membrane; extracellular exosome; extracellular region; extracellular space; Golgi lumen; Golgi membrane; plasma membrane; platelet alpha granule lumen | calcium ion binding endopeptidase inhibitor activity | Homo sapiens | 3D-structure Blood coagulation Calcium Cleavage on pair of basic residues Disease variant Disulfide bond EGF-like domain Fibrinolysis Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Reference proteome Repeat Secreted Signal Thrombophilia Zymogen | MRVLGGRCGA | MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEI... | blood coagulation fibrinolysis blood microparticle; endoplasmic reticulum membrane; extracellular exosome; extracellular region; extracellular space; Golgi lumen; Golgi membrane; plasma membrane; platelet alpha granule lumen calcium ion binding endopeptidase inhibitor activity Homo sapiens 3D-structure Blood coagulatio... |
cell adhesion mediated by integrin integrin-mediated signaling pathway muscle organ development myoblast differentiation myoblast fusion | cell surface; focal adhesion; integrin complex; lamellipodium; melanosome; plasma membrane; ruffle membrane | collagen binding involved in cell-matrix adhesion fibronectin binding integrin binding metal ion binding protein tyrosine kinase binding | Gallus gallus | Calcium Cell adhesion Cell junction Cell membrane Cell projection Disulfide bond EGF-like domain Glycoprotein Integrin Magnesium Membrane Metal-binding Myogenesis Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix | MAETNLTLLT | MAETNLTLLTWAGILCCLIWSGSAQQGGSDCIKANAKSCGECIQAGPNCGWCKKTDFLQEGEPTSARCDDLAALKSKGCPEQDIENPRGSKRVLEDREVTNRKIGAAEKLKPEAITQIQPQKLVLQLRVGEPQTFSLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTALMREMEKITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTGDQNCTSPFSYKNVLSLTSEGNKFNELVGKQHISGNLDSPEGGFDAIMQVAVCGDQIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGKCHLENNMYTMSHYYDY... | cell adhesion mediated by integrin integrin-mediated signaling pathway muscle organ development myoblast differentiation myoblast fusion cell surface; focal adhesion; integrin complex; lamellipodium; melanosome; plasma membrane; ruffle membrane collagen binding involved in cell-matrix adhesion fibronectin binding integ... |
cellular response to hypoxia cellular response to interleukin-7 endoplasmic reticulum to Golgi vesicle-mediated transport insulin processing interleukin-12-mediated signaling pathway interleukin-23-mediated signaling pathway peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of cell adhesion posi... | cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; extracellular exosome; extracellular region; focal adhesion; lamellipodium; melanosome; procollagen-proline 4-dioxyg... | actin binding enzyme binding integrin binding procollagen-proline 4-dioxygenase activity protein disulfide isomerase activity protein heterodimerization activity protein-disulfide reductase activity RNA binding thiol oxidase activity | Homo sapiens | 3D-structure Acetylation Cell membrane Chaperone Craniosynostosis Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Isomerase Membrane Osteogenesis imperfecta Phosphoprotein Redox-active center Reference proteome Repeat Signal | MLRRALLCLA | MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITL... | cellular response to hypoxia cellular response to interleukin-7 endoplasmic reticulum to Golgi vesicle-mediated transport insulin processing interleukin-12-mediated signaling pathway interleukin-23-mediated signaling pathway peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of cell adhesion posi... |
dephosphorylation disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity suppression by virus of host type I interferon-mediated signaling pathway | cytoplasm; host cell cytoplasm; virion component | phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity | Vaccinia virus ) | 3D-structure Host cytoplasm Host-virus interaction Hydrolase Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Inhibition of host STAT1 by virus Late protein Protein phosphatase Reference proteome Viral immunoevasion Virion | MDKKSLYKYL | MDKKSLYKYLLLRSTGDMHKAKSPTIMTRVTNNVYLGNYKNAMDAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCAAGVNRSGAMILAYLMSKNKESLPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN | dephosphorylation disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity suppression by virus of host type I interferon-mediated signaling pathway cytoplasm; host cell cytoplasm; virion component phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activ... |
viral DNA genome replication viral transcription | host cell cytoplasm; viral envelope | translation elongation factor activity | Vaccinia virus ) | Elongation factor Host cytoplasm Phosphoprotein Protein biosynthesis Reference proteome Transcription Transcription regulation Virion | MAWSITNKAD | MAWSITNKADTSSFTKMAEIRAHLKNSAENKDKNEDIFPEDVIIPSTKPKTKRATTPRKPAATKRSTKKEEVEEEVVIEEYHQTTEKNSPSPGVSDIVESVAAVELDDSDGDDEPMVQVEAGKVNHSARSDLSDLKVATDNIVKDLKKIITRISAVSTVLEDVQAAGISRQFTSMTKAITTLSDLVTEGKSKVVRKKVKTCKK | viral DNA genome replication viral transcription host cell cytoplasm; viral envelope translation elongation factor activity Vaccinia virus )Elongation factor Host cytoplasm Phosphoprotein Protein biosynthesis Reference proteome Transcription Transcription regulation Virion MAWSITNKAD MAWSITNKADTSSFTKMAEIRAHLKNSAENKDK... |
de novo' IMP biosynthetic process adenine biosynthetic process purine nucleobase metabolic process purine nucleotide biosynthetic process | cytoplasm; cytosol | ATP binding metal ion binding phosphoribosylamine-glycine ligase activity phosphoribosylformylglycinamidine cyclo-ligase activity | Saccharomyces cerevisiae | ATP-binding Cytoplasm Direct protein sequencing Ligase Magnesium Manganese Metal-binding Multifunctional enzyme Nucleotide-binding Phosphoprotein Purine biosynthesis Reference proteome | MLNILVLGNG | MLNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPDVANFARLQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIPTASYDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGGMGAYAPAPVATPSLLKTIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLVPEVLEYNVRFGDPETQAVLSLLDDQTD... | de novo' IMP biosynthetic process adenine biosynthetic process purine nucleobase metabolic process purine nucleotide biosynthetic process cytoplasm; cytosol ATP binding metal ion binding phosphoribosylamine-glycine ligase activity phosphoribosylformylglycinamidine cyclo-ligase activity Saccharomyces cerevisiae ATP-bin... |
folic acid-containing compound metabolic process histidine biosynthetic process methionine biosynthetic process purine nucleobase biosynthetic process purine nucleotide biosynthetic process tetrahydrofolate interconversion | cytoplasm; cytosol; nucleus | ATP binding formate-tetrahydrofolate ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity | Saccharomyces cerevisiae | Amino-acid biosynthesis ATP-binding Cytoplasm Direct protein sequencing Histidine biosynthesis Hydrolase Ligase Methionine biosynthesis Multifunctional enzyme NADP Nucleotide-binding Nucleus One-carbon metabolism Oxidoreductase Phosphoprotein Purine biosynthesis Reference proteome | MAGQVLDGKA | MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPV... | folic acid-containing compound metabolic process histidine biosynthetic process methionine biosynthetic process purine nucleobase biosynthetic process purine nucleotide biosynthetic process tetrahydrofolate interconversion cytoplasm; cytosol; nucleus ATP binding formate-tetrahydrofolate ligase activity methenyltetrahyd... |
amino acid catabolic process to alcohol via Ehrlich pathway NADH oxidation | cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrion | alcohol dehydrogenase (NAD+) activity butanol dehydrogenase activity zinc ion binding | Saccharomyces cerevisiae | Membrane Metal-binding Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Reference proteome Transit peptide Zinc | MLRTSTLFTR | MLRTSTLFTRRVQPSLFSRNILRLQSTAAIPKTQKGVIFYENKGKLHYKDIPVPEPKPNEILINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVKLGSNVKGWKVGDLAGIKWLNGSCMTCEFCESGHESNCPDADLSGYTHDGSFQQFATADAIQAAKIQQGTDLAEVAPILCAGVTVYKALKEADLKAGDWVAISGAAGGLGSLAVQYATAMGYRVLGIDAGEEKEKLFKKLGGEVFIDFTKTKNMVSDIQEATKGGPHGVINVSVSEAAISLSTEYVRPCGTVVLVGLPANAYVKSEVFSHVVKSINIKG... | amino acid catabolic process to alcohol via Ehrlich pathway NADH oxidation cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrion alcohol dehydrogenase (NAD+) activity butanol dehydrogenase activity zinc ion binding Saccharomyces cerevisiae Membrane Metal-binding Mitochondrion Mitochondrion inner... |
axon guidance compound eye development heterochromatin formation Malpighian tubule bud morphogenesis muscle organ development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II neuroblast fate determination regulation of development, heterochronic regulation of ... | nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding | Drosophila melanogaster | Developmental protein DNA-binding Gap protein Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Zinc Zinc-finger | MSISMLQDAQ | MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAAAASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQ... | axon guidance compound eye development heterochromatin formation Malpighian tubule bud morphogenesis muscle organ development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II neuroblast fate determination regulation of development, heterochronic regulation of ... |
arginine metabolic process positive regulation of transcription by RNA polymerase II regulation of arginine biosynthetic process regulation of arginine catabolic process regulation of arginine metabolic process | nucleus; RNA polymerase II transcription regulator complex | cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding | Saccharomyces cerevisiae | Arginine metabolism DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MTSNSDGSST | MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSPEQDQEGDFDEEDDDDKFSVSTSTPTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANILLLILANSGLVYTFTTPKLEPVVREDEGKSLIRACINASDTPDATDTSPAQEQSPAN | arginine metabolic process positive regulation of transcription by RNA polymerase II regulation of arginine biosynthetic process regulation of arginine catabolic process regulation of arginine metabolic process nucleus; RNA polymerase II transcription regulator complex cis-regulatory region sequence-specific DNA bindin... |
arginine metabolic process inositol phosphate biosynthetic process macroautophagy negative regulation of transcription by RNA polymerase II phosphatidylinositol phosphate biosynthetic process phosphorylation positive regulation of transcription by RNA polymerase II protein stabilization regulation of arginine metabolic... | cytoplasm; nucleus; RNA polymerase II transcription regulator complex | 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ATP binding inositol hexakisphosphate kinase activity inositol tetrakisphosphate 3-kinase activity inositol tetrakisphosphate 6-kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol-1,4,5-trisphosp... | Saccharomyces cerevisiae | 3D-structure Acetylation Arginine metabolism ATP-binding Calcium Kinase Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Transferase | MDTVNNYRVL | MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSS... | arginine metabolic process inositol phosphate biosynthetic process macroautophagy negative regulation of transcription by RNA polymerase II phosphatidylinositol phosphate biosynthetic process phosphorylation positive regulation of transcription by RNA polymerase II protein stabilization regulation of arginine metabolic... |
proton motive force-driven ATP synthesis | cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial nucleoid; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase, catalytic core; mitochondrion; proton-transporting ATP synthase complex, catalytic core F(1) | ADP binding ATP binding proton-transporting ATP synthase activity, rotational mechanism | Saccharomyces cerevisiae | 3D-structure ATP synthesis ATP-binding CF(1) Hydrogen ion transport Ion transport Membrane Mitochondrion Mitochondrion inner membrane Nucleotide-binding Phosphoprotein Reference proteome Transit peptide Transport | MLARTAAIRS | MLARTAAIRSLSRTLINSTKAARPAAAALASTRRLASTKAQPTEVSSILEERIKGVSDEANLNETGRVLAVGDGIARVFGLNNIQAEELVEFSSGVKGMALNLEPGQVGIVLFGSDRLVKEGELVKRTGNIVDVPVGPGLLGRVVDALGNPIDGKGPIDAAGRSRAQVKAPGILPRRSVHEPVQTGLKAVDALVPIGRGQRELIIGDRQTGKTAVALDTILNQKRWNNGSDESKKLYCVYVAVGQKRSTVAQLVQTLEQHDAMKYSIIVAATASEAAPLQYLAPFTAASIGEWFRDNGKHALIVYDDLSKQAVAYRQLSL... | proton motive force-driven ATP synthesis cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial nucleoid; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase, catalytic core; mitochondrion; proton-transporting ATP synthase complex, cata... |
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