Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction regulation of acrosome reaction regulation of store-operated calcium entry sperm capacitation | extracellular space | peptidase inhibitor activity serine-type endopeptidase inhibitor activity | Mus musculus | Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MKVAVIFLLS | MKVAVIFLLSALALLSLAGNTFSAKVTGKEASCHDAVAGCPRIYDPVCGTDGITYANECVLCFENRKRIEPVLIRKGGPC | negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction regulation of acrosome reaction regulation of store-operated calcium entry sperm capacitation extracellular space ... |
adult feeding behavior adult locomotory behavior inter-male aggressive behavior larval locomotory behavior multicellular organismal response to stress neuromuscular junction development neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration regulation of smooth muscle contraction | extracellular space | neuropeptide hormone activity neuropeptide receptor binding | Drosophila melanogaster | Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Reference proteome Secreted Signal Sulfation | MGPRSCTHFA | MGPRSCTHFATLFMPLWALAFCFLVVLPIPAQTTSLQNAKDDRRLQELESKIGGEIDQPIANLVGPSFSLFGDRRNQKTMSFGRRVPLISRPIIPIELDLLMDNDDERTKAKRFDDYGHMRFGKRGGDDQFDDYGHMRFGR | adult feeding behavior adult locomotory behavior inter-male aggressive behavior larval locomotory behavior multicellular organismal response to stress neuromuscular junction development neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration regulation of smooth muscle contraction extr... |
flagellated sperm motility gluconeogenesis glycolytic process phosphorylation | cilium; cytosol; sperm fibrous sheath | ADP binding ATP binding phosphoglycerate kinase activity | Mus musculus | 3D-structure Acetylation ATP-binding Cytoplasm Glycolysis Kinase Nucleotide-binding Phosphoprotein Reference proteome Transferase | MALSAKLTLD | MALSAKLTLDKVDLKGKRVIMRVDFNVPMKNNQITNNQRIKAAIPSIKHCLDNGAKSVVLMSHLGRPDGIPMPDKYSLEPVADELKSLLNKDVIFLKDCVGPEVEQACANPDNGSIILLENLRFHVEEEGKGKDSSGKKISADPAKVEAFQASLSKLGDVYVNDAFGTAHRAHSSTVGVNLPQKASGFLMKKELDYFSKALEKPERPFLAILGGAKVKDKIQLIKNMLDKVNFMIIGGGMAYTFLKELKNMQIGASLFDEEGATIVKEIMEKAEKNGVKIVFPVDFVTGDKFDENAKVGQATIESGIPSGWMGLDCGPES... | flagellated sperm motility gluconeogenesis glycolytic process phosphorylation cilium; cytosol; sperm fibrous sheath ADP binding ATP binding phosphoglycerate kinase activity Mus musculus 3D-structure Acetylation ATP-binding Cytoplasm Glycolysis Kinase Nucleotide-binding Phosphoprotein Reference proteome Transferase MALS... |
cell differentiation gamete generation oogenesis protein localization secondary piRNA processing | cytoplasm; germ cell nucleus; nucleus; P granule; posterior cell cortex | ATP binding ATP hydrolysis activity RNA binding RNA helicase activity | Drosophila melanogaster | 3D-structure Alternative splicing ATP-binding Cytoplasm Developmental protein Differentiation Helicase Hydrolase Magnesium Nucleotide-binding Oogenesis Phosphoprotein Reference proteome Repeat RNA-binding Ubl conjugation | MSDDWDDEPI | MSDDWDDEPIVDTRGARGGDWSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQGGNRDVFGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFARRRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPHELELGRPQ... | cell differentiation gamete generation oogenesis protein localization secondary piRNA processing cytoplasm; germ cell nucleus; nucleus; P granule; posterior cell cortex ATP binding ATP hydrolysis activity RNA binding RNA helicase activity Drosophila melanogaster 3D-structure Alternative splicing ATP-binding Cytoplasm D... |
cell population proliferation kidney development polyamine metabolic process positive regulation of cell population proliferation putrescine biosynthetic process putrescine biosynthetic process from ornithine regulation of protein catabolic process response to virus | cytoplasm; cytosol; perinuclear region of cytoplasm | ornithine decarboxylase activity protein homodimerization activity | Rattus norvegicus | Decarboxylase Direct protein sequencing Lyase Phosphoprotein Polyamine biosynthesis Pyridoxal phosphate Reference proteome S-nitrosylation | MGSFTKEEFD | MGSFTKEEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDVLKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPPERIIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMGTEVGFSMYLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQTGSDDEDESNEQTLMYYVND... | cell population proliferation kidney development polyamine metabolic process positive regulation of cell population proliferation putrescine biosynthetic process putrescine biosynthetic process from ornithine regulation of protein catabolic process response to virus cytoplasm; cytosol; perinuclear region of cytoplasm o... |
formation of cytoplasmic translation initiation complex formation of translation preinitiation complex translational initiation | cytosol; eukaryotic 43S preinitiation complex; eukaryotic translation initiation factor 2 complex; multi-eIF complex; ribosome | metal ion binding mRNA binding translation initiation factor activity translation initiation factor binding | Saccharomyces cerevisiae | 3D-structure Cytoplasm Initiation factor Metal-binding Phosphoprotein Protein biosynthesis Reference proteome Zinc Zinc-finger | MSSDLAAELG | MSSDLAAELGFDPALKKKKKTKKVIPDDFDAAVNGKENGSGDDLFAGLKKKKKKSKSVSADAEAEKEPTDDIAEALGELSLKKKKKKTKDSSVDAFEKELAKAGLDNVDAESKEGTPSANSSIQQEVGLPYSELLSRFFNILRTNNPELAGDRSGPKFRIPPPVCLRDGKKTIFSNIQDIAEKLHRSPEHLIQYLFAELGTSGSVDGQKRLVIKGKFQSKQMENVLRRYILEYVTCKTCKSINTELKREQSNRLFFMVCKSCGSTRSVSSIKTGFQATVGKRRRM | formation of cytoplasmic translation initiation complex formation of translation preinitiation complex translational initiation cytosol; eukaryotic 43S preinitiation complex; eukaryotic translation initiation factor 2 complex; multi-eIF complex; ribosome metal ion binding mRNA binding translation initiation factor acti... |
adult locomotory behavior cerebellum development dopaminergic neuron differentiation dorsal/ventral pattern formation drinking behavior embryonic brain development embryonic forelimb morphogenesis embryonic limb morphogenesis hindbrain development limb development midbrain development midbrain-hindbrain boundary develo... | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MEEQQPEPKS | MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAPDANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFT... | adult locomotory behavior cerebellum development dopaminergic neuron differentiation dorsal/ventral pattern formation drinking behavior embryonic brain development embryonic forelimb morphogenesis embryonic limb morphogenesis hindbrain development limb development midbrain development midbrain-hindbrain boundary develo... |
dopaminergic neuron differentiation embryonic brain development hindbrain development midbrain development negative regulation of neuron apoptotic process neuron development neuron differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | fibrillar center; nucleolus; nucleoplasm; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MEEKDSKPSE | MEEKDSKPSETAAEAQRQPEPSSGGGSGGGSSPSDSDTGRRRALMLPEVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGARGGEGGAGTTEGGGGGAGGAEQLLGARESRPNPACAPSAGGTLSAAAGDPAVDGEGGSKTLSLHGGAKKPGDPGGSLDGVLKARGLGGGDLSVSSDSDSSQASATLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGK... | dopaminergic neuron differentiation embryonic brain development hindbrain development midbrain development negative regulation of neuron apoptotic process neuron development neuron differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II fibrillar center... |
anatomical structure morphogenesis anterior/posterior pattern specification embryonic skeletal system morphogenesis endothelial cell differentiation regulation of transcription by RNA polymerase II | chromatin; cytosol; fibrillar center; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSSYFVNSFS | MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGDSHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP | anatomical structure morphogenesis anterior/posterior pattern specification embryonic skeletal system morphogenesis endothelial cell differentiation regulation of transcription by RNA polymerase II chromatin; cytosol; fibrillar center; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II... |
anterior/posterior pattern specification midgut development positive regulation of transcription by RNA polymerase II salivary gland boundary specification sex comb development | nucleoplasm; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific DNA binding | Drosophila melanogaster | 3D-structure Developmental protein DNA-binding Homeobox Nucleus Phosphoprotein Reference proteome | MDPDCFAMSS | MDPDCFAMSSYQFVNSLASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNA... | anterior/posterior pattern specification midgut development positive regulation of transcription by RNA polymerase II salivary gland boundary specification sex comb development nucleoplasm; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific protein homodimerization activity RNA polymerase II ... |
anterior/posterior pattern specification embryonic skeletal system development embryonic skeletal system morphogenesis endothelial cell differentiation positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | cytosol; fibrillar center; nucleoplasm; nucleus | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSSYFVNSFS | MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPASAQEPRFRQATSSCSLSSPESLPCTNGDSHGAKPSASSPSDQATPASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP | anterior/posterior pattern specification embryonic skeletal system development embryonic skeletal system morphogenesis endothelial cell differentiation positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II cytosol; fibrillar ... |
anterior region determination anterior/posterior axis specification anterior/posterior axis specification, embryo maternal determination of anterior/posterior axis, embryo negative regulation of translation oogenesis positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription reg... | nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific mRNA 3'-UTR binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding translation repressor activity | Drosophila melanogaster | 3D-structure Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Reference proteome RNA-binding Transcription Transcription regulation | MAQPPPDQNF | MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDFQQKQASACRVLVKDEPEADY... | anterior region determination anterior/posterior axis specification anterior/posterior axis specification, embryo maternal determination of anterior/posterior axis, embryo negative regulation of translation oogenesis positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription reg... |
anatomical structure development chemical synaptic transmission neurogenesis regulation of synaptic activity regulation of transcription by RNA polymerase II salivary gland morphogenesis segment polarity determination ventral cord development | cytoplasm; nucleus; synapse | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding | Drosophila melanogaster | Developmental protein DNA-binding Homeobox Nucleus Paired box Reference proteome Segmentation polarity protein Transcription Transcription regulation | MAVSALNMTP | MAVSALNMTPYFGGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRGSSGSGTSHSIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSVASMSPASSTSGTSSAAHSPVQ... | anatomical structure development chemical synaptic transmission neurogenesis regulation of synaptic activity regulation of transcription by RNA polymerase II salivary gland morphogenesis segment polarity determination ventral cord development cytoplasm; nucleus; synapse DNA-binding transcription factor activity, RNA po... |
anatomical structure development neurogenesis regulation of transcription by RNA polymerase II segment polarity determination | nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding | Drosophila melanogaster | Developmental protein DNA-binding Homeobox Nucleus Paired box Phosphoprotein Reference proteome Segmentation polarity protein Transcription Transcription regulation | MDMSSANSLR | MDMSSANSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFADPPSTSSISRLLRGSDRGSEDGRKDYTINGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGLSPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMAGYSPAPGTTATGAGMNDGVHHAAHAPSSHHSAATAAAA... | anatomical structure development neurogenesis regulation of transcription by RNA polymerase II segment polarity determination nucleus DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription re... |
anatomical structure development animal organ morphogenesis bone morphogenesis CD4-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation cell population proliferation parathyroid gland development pattern specification process positive regulation of transcription by RNA polymerase ... | nucleus; transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Activator Developmental protein Disease variant DNA-binding Nucleus Paired box Reference proteome Transcription Transcription regulation | MKFTLGLGSR | MKFTLGLGSRAWRVSWERAAAAAAGPGAGGALGSGSLRVSSRRGPRLARALPLCLSGGGGARALPDCAGPSPRRSGARQLAGPRAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGTHPGVPGSAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGAAYSPKMEDWAGVNRA... | anatomical structure development animal organ morphogenesis bone morphogenesis CD4-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation cell population proliferation parathyroid gland development pattern specification process positive regulation of transcription by RNA polymerase ... |
analia development animal organ morphogenesis anterior/posterior axis specification blastoderm segmentation cell differentiation gastrulation involving germ band extension genital disc anterior/posterior pattern formation genital disc development germ-band extension hindgut morphogenesis Malpighian tubule morphogenesis... | cytoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding | Drosophila melanogaster | Alternative splicing Developmental protein DNA-binding Gastrulation Homeobox Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MVSHYYNTLP | MVSHYYNTLPYTQKHSAANLAYASAAGQPWNWTPNYHHTPPNHQFLGDVDSSHAAHHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIW... | analia development animal organ morphogenesis anterior/posterior axis specification blastoderm segmentation cell differentiation gastrulation involving germ band extension genital disc anterior/posterior pattern formation genital disc development germ-band extension hindgut morphogenesis Malpighian tubule morphogenesis... |
cellular response to virus humoral immune response positive regulation of interleukin-6 production positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding | Homo sapiens | 3D-structure Activator Alternative splicing Cytoplasm DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MVHSSMGAPE | MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQ... | cellular response to virus humoral immune response positive regulation of interleukin-6 production positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus DNA-binding transcription fac... |
determination of genital disc primordium external genitalia morphogenesis female genitalia development genital disc anterior/posterior pattern formation genital disc sexually dimorphic development germ cell migration gonadal mesoderm development imaginal disc-derived female genitalia development male genitalia developm... | nucleus; polytene chromosome band | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding | Drosophila melanogaster | 3D-structure Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MQQHHLQQQQ | MQQHHLQQQQQQQQQQEQQHLQEQQQHLQQLHHHAHHHLPQPLHTTSHHHSAHPHLQQQQQQQQHAVVASSPSSVLQQQQQQSTPTTHSTPTHAVMYEDPPPVPLVAVQQQHLPAPQQQQQLQQQQQQQQQQLATTPVAGALSPAQTPTGPSAQQQQHLTSPHHQQLPQQQTPNSVASGASSNLQQQQQQQNAAVAPGQTQIVAPTTASVSPSSVSSQKEDINMSIQLAPLHIPAIRAGPGFETDTSAAVKRHTAHWAYNDEGFNQHYGSGYYDRKHMFAYPYPETQFPVGQYWGPNYRPDQTTSAAAAAAYMNEAERHV... | determination of genital disc primordium external genitalia morphogenesis female genitalia development genital disc anterior/posterior pattern formation genital disc sexually dimorphic development germ cell migration gonadal mesoderm development imaginal disc-derived female genitalia development male genitalia developm... |
mechanosensory behavior neuron differentiation neuron projection organization positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II response to mechanical stimulus | nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding | Caenorhabditis elegans | Alternative splicing Developmental protein DNA-binding Homeobox LIM domain Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc | MEMLESKPLS | MEMLESKPLSAISMVIDSIGVDHENQNKCNCCNEQIYDRYIYRMDNRSYHENCVKCTICESPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSLCGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDESFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDTTDFNAFCGNFEEEDDE... | mechanosensory behavior neuron differentiation neuron projection organization positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II response to mechanical stimulus nucleus; RNA polymerase II transcription regulator complex DN... |
protein folding response to endoplasmic reticulum stress | endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane | protein disulfide isomerase activity | Gallus gallus | Cell membrane Chaperone Direct protein sequencing Disulfide bond Endoplasmic reticulum Isomerase Membrane Redox-active center Reference proteome Repeat Signal | MAVVRVRAIV | MAVVRVRAIVALLCLVAALGLAEPLEEEDGVLVLRAANFEQALAAHRHLLVEFYAPWCGHCKALAPEYAKAAAQLKAEGSEIRLAKVDATEEAELAQQFGVRGYPTIKFFRNGDKAAPREYTAGREADDIVSWLKKRTGPAATTLTDAAAAETLVDSSEVVVIGFFKDVTSDAAKEFLLAAESVDDIPFGISSSADVFSKYQLSQDGVVLFKKFDEGRNNFEGDLTKDNLLNFIKSNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYEGKLDNFKTAAGNFKGKILFIFIDSDHSDNQRILEFFGLKKEECPAV... | protein folding response to endoplasmic reticulum stress endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane protein disulfide isomerase activity Gallus gallus Cell membrane Chaperone Direct protein sequencing Disulfide bond Endoplasmic reticulum Isomerase Membrane Redox-active center R... |
cellular response to hypoxia cellular response to interleukin-7 endoplasmic reticulum to Golgi vesicle-mediated transport insulin processing positive regulation of cell adhesion positive regulation of substrate adhesion-dependent cell spreading positive regulation of viral entry into host cell protein folding protein f... | cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; lamellipodium; melanosome; procollagen-proline 4-dioxygenase complex; protein-containing complex | actin binding enzyme binding integrin binding procollagen-proline 4-dioxygenase activity protein disulfide isomerase activity protein heterodimerization activity protein-containing complex binding protein-disulfide reductase activity thiol oxidase activity | Mus musculus | Acetylation Cell membrane Chaperone Disulfide bond Endoplasmic reticulum Isomerase Membrane Phosphoprotein Redox-active center Reference proteome Repeat Signal | MLSRALLCLA | MLSRALLCLALAWAARVGADALEEEDNVLVLKKSNFEEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAKQFLLAAEAIDDIPFGITSNSGVFSKYQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSSFKRAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLI... | cellular response to hypoxia cellular response to interleukin-7 endoplasmic reticulum to Golgi vesicle-mediated transport insulin processing positive regulation of cell adhesion positive regulation of substrate adhesion-dependent cell spreading positive regulation of viral entry into host cell protein folding protein f... |
canonical glycolysis gluconeogenesis glycolytic process | cytosol; extracellular exosome; extracellular space; membrane; perikaryon; phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane | magnesium ion binding phosphopyruvate hydratase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Glycolysis Hydroxylation Isopeptide bond Lyase Magnesium Membrane Metal-binding Phosphoprotein Reference proteome Ubl conjugation | MSIEKIWARE | MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDL... | canonical glycolysis gluconeogenesis glycolytic process cytosol; extracellular exosome; extracellular space; membrane; perikaryon; phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane magnesium ion binding phosphopyruvate hydratase activity Homo sapiens 3D-structure Acetylation Alternative sp... |
alpha-linolenic acid metabolic process bile acid metabolic process fatty acid beta-oxidation fatty acid beta-oxidation using acyl-CoA oxidase phenylacetate catabolic process very long-chain fatty acid metabolic process | cytosol; extracellular region; membrane; peroxisomal matrix; peroxisome; specific granule lumen | acetate CoA-transferase activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity acetyl-CoA C-myristoyltransferase activity palmitoyl-CoA oxidase activity | Homo sapiens | 3D-structure Acyltransferase Alternative splicing Fatty acid metabolism Lipid metabolism Peroxisome Phosphoprotein Reference proteome Transferase Transit peptide | MQRLQVVLGH | MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIG... | alpha-linolenic acid metabolic process bile acid metabolic process fatty acid beta-oxidation fatty acid beta-oxidation using acyl-CoA oxidase phenylacetate catabolic process very long-chain fatty acid metabolic process cytosol; extracellular region; membrane; peroxisomal matrix; peroxisome; specific granule lumen aceta... |
animal organ regeneration epithelial cell differentiation fructose 1,6-bisphosphate metabolic process gluconeogenesis glycolytic process response to hypoxia response to organic cyclic compound response to organonitrogen compound | axon; cytosol; postsynaptic cytosol | cytoskeletal protein binding fructose-bisphosphate aldolase activity identical protein binding protein-containing complex binding | Rattus norvegicus | Acetylation Direct protein sequencing Glycolysis Lyase Phosphoprotein Reference proteome Schiff base | MPHSYPALSA | MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQEKGILVGIKVDKGVVPLAGTDGETTTQGLDGLLERCAQYKKDGADFAKWRCVLKISDRTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQFVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASLNLNAINRCSLPRPWALTFSYGRALQASALSAWRGQRDN... | animal organ regeneration epithelial cell differentiation fructose 1,6-bisphosphate metabolic process gluconeogenesis glycolytic process response to hypoxia response to organic cyclic compound response to organonitrogen compound axon; cytosol; postsynaptic cytosol cytoskeletal protein binding fructose-bisphosphate aldo... |
purine nucleobase catabolic process urate catabolic process | peroxisomal matrix; peroxisome | urate oxidase activity | Rattus norvegicus | Acetylation Direct protein sequencing Oxidoreductase Peroxisome Phosphoprotein Purine metabolism Reference proteome | MAHYHDDYGK | MAHYHDDYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHVLAKFKGIKSIETFAMNICEHFLSSFSHVTRAHVYVEEVPWKRFEKNGVKHVHAFIHTPTGTHFCDVEQVRNGPPIIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCKWRYQNRDVDFEATWGAVRDIVLKKFAGPYDRGEYSPSVQKTLYDIQVLTLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGKITGTVRRKLPSRL | purine nucleobase catabolic process urate catabolic process peroxisomal matrix; peroxisome urate oxidase activity Rattus norvegicus Acetylation Direct protein sequencing Oxidoreductase Peroxisome Phosphoprotein Purine metabolism Reference proteome MAHYHDDYGK MAHYHDDYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGD... |
cell division DNA replication initiation G1/S transition of mitotic cell cycle mitotic DNA replication checkpoint signaling pre-replicative complex assembly involved in nuclear cell cycle DNA replication regulation of DNA-templated DNA replication initiation | chromosome; cytoplasm; DNA replication preinitiation complex; nuclear pre-replicative complex; nucleoplasm; nucleus | ATP binding ATP hydrolysis activity chromatin binding DNA replication origin binding GTP binding GTPase activity | Saccharomyces cerevisiae | 3D-structure ATP-binding Cell cycle Cell division Chromosome DNA replication Nucleotide-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation | MSAIPITPTK | MSAIPITPTKRIRRNLFDDAPATPPRPLKRKKLQFTDVTPESSPEKLQFGSQSIFLRTKALLQKSSELVNLNSSDGALPARTAEYEQVMNFLAKAISEHRSDSLYITGPPGTGKTAQLDMIIRQKFQSLPLSLSTPRSKDVLRHTNPNLQNLSWFELPDGRLESVAVTSINCISLGEPSSIFQKIFDSFQDLNGPTLQIKNMQHLQKFLEPYHKKTTFVVVLDEMDRLLHANTSETQSVRTILELFLLAKLPTVSFVLIGMANSLDMKDRFLSRLNLDRGLLPQTIVFQPYTAEQMYEIVIQKMSSLPTIIFQPMAIKFA... | cell division DNA replication initiation G1/S transition of mitotic cell cycle mitotic DNA replication checkpoint signaling pre-replicative complex assembly involved in nuclear cell cycle DNA replication regulation of DNA-templated DNA replication initiation chromosome; cytoplasm; DNA replication preinitiation complex;... |
glucose metabolic process glycolytic process | cytoplasm | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity NAD binding NADP binding | Bacillus subtilis | Cytoplasm Direct protein sequencing Glycolysis NAD Nucleotide-binding Oxidoreductase Reference proteome | MAVKVGINGF | MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHLLQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTKRADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPFAKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSLVLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYSEEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYS... | glucose metabolic process glycolytic process cytoplasm glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity NAD binding NADP binding Bacillus subtilis Cytoplasm Direct protein sequencing Glycolysis NAD Nucleotide-binding Oxidoreductase Reference proteome MAVKVGINGF MAVKVGINGFGRIGRNVFRAALNNPEVEVVAV... |
unidirectional conjugation | plasma membrane | ATP binding | Escherichia coli | 3D-structure ATP-binding Cell inner membrane Cell membrane Conjugation Membrane Nucleotide-binding Plasmid Transmembrane Transmembrane helix | MSFNAKDMTQ | MSFNAKDMTQGGQIASMRIRMFSQIANIMLYCLFIFFWILVGLVLWIKISWQTFVNGCIYWWCTTLEGMRDLIKSQPVYEIQYYGKTFRMNAAQVLHDKYMIWCSEQLWSAFVLAAVVALVICLITFFVVSWILGRQGKQQSENEVTGGRQLTDNPKDVARMLKKDGKDSDIRIGDLPIIRDSEIQNFCLHGTVGAGKSEVIRRLANYARQRGDMVVIYDRSGEFVKSYYDPSIDKILNPLDARCAAWDLWKECLTQPDFDNTANTLIPMGTKEDPFWQGSGRTIFAEAAYLMRNDPNRSYSKLVDTLLSIKIEKLRTYL... | unidirectional conjugation plasma membrane ATP binding Escherichia coli 3D-structure ATP-binding Cell inner membrane Cell membrane Conjugation Membrane Nucleotide-binding Plasmid Transmembrane Transmembrane helix MSFNAKDMTQ MSFNAKDMTQGGQIASMRIRMFSQIANIMLYCLFIFFWILVGLVLWIKISWQTFVNGCIYWWCTTLEGMRDLIKSQPVYEIQYYGKTFRMNAAQVL... |
cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition | cytosol; nuclear body; nucleolus; signal recognition particle; signal recognition particle, endoplasmic reticulum targeting | 7S RNA binding RNA binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Nucleus Reference proteome Ribonucleoprotein RNA-binding Signal recognition particle | MACAAARSPA | MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK | cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition cytosol; nuclear body; nucleolus; signal recognition particle; signal recognition particle, endoplasmic reticulum targeting 7S RNA binding RNA binding Homo sapiens 3D-structure Alternat... |
glycine biosynthetic process, by transamination of glyoxylate glyoxylate catabolic process glyoxylate metabolic process L-alanine catabolic process L-cysteine catabolic process L-serine metabolic process Notch signaling pathway oxalic acid secretion pyruvate biosynthetic process response to cAMP response to glucocortic... | mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome | alanine-glyoxylate transaminase activity amino acid binding identical protein binding protein homodimerization activity protein self-association pyridoxal phosphate binding serine-pyruvate transaminase activity transaminase activity | Rattus norvegicus | Acetylation Alternative initiation Aminotransferase Direct protein sequencing Mitochondrion Peroxisome Pyridoxal phosphate Reference proteome Transferase Transit peptide | MFRMLAKASV | MFRMLAKASVTLGSRAASWVRNMGSHQLLVPPPEALSKPLSIPKRLLLGPGPSNLAPRVLAAGSLRMIGHMQKEMFQIMDEIKQGIQYVFQTRNPLTLVVSGSGHCAMETALFNLLEPGDSFLVGTNGIWGIRAAEIAERIGARVHQMIKKPGEHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYQCLLLVDSVASLGGVPIYMDQQGIDILYSGSQKVLNAPPGISLISFNDKAKSKVYSRKTKPVSFYTDITYLSKLWGCEGKTRVIHHTLPVISLYCLRESLALISEQGLENSWRRHREATAHL... | glycine biosynthetic process, by transamination of glyoxylate glyoxylate catabolic process glyoxylate metabolic process L-alanine catabolic process L-cysteine catabolic process L-serine metabolic process Notch signaling pathway oxalic acid secretion pyruvate biosynthetic process response to cAMP response to glucocortic... |
photosynthesis | chloroplast thylakoid membrane; photosystem I | 4 iron, 4 sulfur cluster binding chlorophyll binding electron transfer activity magnesium ion binding | Chlamydomonas reinhardtii | 3D-structure 4Fe-4S Chlorophyll Chloroplast Chromophore Electron transport Iron Iron-sulfur Magnesium Membrane Metal-binding Oxidoreductase Photosynthesis Photosystem I Plastid Reference proteome Thylakoid Transmembrane Transmembrane helix Transport | MATKLFPKFS | MATKLFPKFSQGLAQDPTTRRIWYGLAMAHDFESHDGMTEENLYQKIFASHFGQLSIIFLWTSGNLFHVAWQGNFEQWVTDPVHIRPIAHAIWDPHFGQPAVEAFTRGGASGPVNISTSGVYQWWYTIGMRTNQDLYVGSVFLALVSAIFLFAGWLHLQPNFQPSLSWFKDAESRLNHHLSGLFGVSSLAWTGHLVHVAIPESRGQHVGWDNFLSVLPHPQGLTPFFTGNWAAYAQSPDTASHVFGTAQGSGQAILTFLGGFHPQTQSLWLTDMAHHHLAIAVIFIVAGHMYRTNFGIGHRMQAILEAHTPPSGSLGAGH... | photosynthesis chloroplast thylakoid membrane; photosystem I 4 iron, 4 sulfur cluster binding chlorophyll binding electron transfer activity magnesium ion binding Chlamydomonas reinhardtii 3D-structure 4Fe-4S Chlorophyll Chloroplast Chromophore Electron transport Iron Iron-sulfur Magnesium Membrane Metal-binding Oxidor... |
carbohydrate metabolic process colanic acid biosynthetic process galactose catabolic process via UDP-galactose galactose metabolic process | cytoplasm; cytosol | identical protein binding NAD+ binding racemase and epimerase activity, acting on carbohydrates and derivatives UDP-glucose 4-epimerase activity | Escherichia coli | 3D-structure Carbohydrate metabolism Galactose metabolism Isomerase NAD Reference proteome | MRVLVTGGSG | MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDE... | carbohydrate metabolic process colanic acid biosynthetic process galactose catabolic process via UDP-galactose galactose metabolic process cytoplasm; cytosol identical protein binding NAD+ binding racemase and epimerase activity, acting on carbohydrates and derivatives UDP-glucose 4-epimerase activity Escherichia coli ... |
galactose catabolic process via UDP-galactose | cytoplasm; cytosol | ferrous iron binding galactokinase activity UDP-glucose:hexose-1-phosphate uridylyltransferase activity zinc ion binding | Escherichia coli | 3D-structure Carbohydrate metabolism Galactose metabolism Iron Metal-binding Nucleotidyltransferase Reference proteome Transferase Zinc | MTQFNPVDHP | MTQFNPVDHPHRRYNPLTGQWILVSPHRAKRPWQGAQETPAKQVLPAHDPDCFLCAGNVRVTGDKNPDYTGTYVFTNDFAALMSDTPDAPESHDPLMRCQSARGTSRVICFSPDHSKTLPELSVAALTEIVKTWQEQTAELGKTYPWVQVFENKGAAMGCSNPHPHGQIWANSFLPNEAEREDRLQKEYFAEQKSPMLVDYVQRELADGSRTVVETEHWLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRSDLALALKKLTSRYDNLFQCSFPYSMGWHGAPFNGEENQHWQLHAHFYPPLLRSATVRKFMVGYEMLA... | galactose catabolic process via UDP-galactose cytoplasm; cytosol ferrous iron binding galactokinase activity UDP-glucose:hexose-1-phosphate uridylyltransferase activity zinc ion binding Escherichia coli 3D-structure Carbohydrate metabolism Galactose metabolism Iron Metal-binding Nucleotidyltransferase Reference proteom... |
spermidine biosynthetic process | cytosol | cadaverine aminopropyltransferase activity protein homodimerization activity spermidine synthase activity spermine synthase activity thermospermine synthase activity | Escherichia coli | 3D-structure Cytoplasm Direct protein sequencing Polyamine biosynthesis Reference proteome Spermidine biosynthesis Transferase | MAEKKQWHET | MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAIHTAAFALPQYLQDALASQPS | spermidine biosynthetic process cytosol cadaverine aminopropyltransferase activity protein homodimerization activity spermidine synthase activity spermine synthase activity thermospermine synthase activity Escherichia coli 3D-structure Cytoplasm Direct protein sequencing Polyamine biosynthesis Reference proteome Spermi... |
proteolysis | cell outer membrane | aspartic-type endopeptidase activity endopeptidase activity serine-type endopeptidase activity | Escherichia coli | 3D-structure Aspartyl protease Cell outer membrane Direct protein sequencing Hydrolase Membrane Protease Reference proteome Signal Transmembrane Transmembrane beta strand | MRAKLLGIVL | MRAKLLGIVLTTPIAISSFASTETLSFTPDNINADISLGTLSGKTKERVYLAEEGGRKVSQLDWKFNNAAIIKGAINWDLMPQISIGAAGWTTLGSRGGNMVDQDWMDSSNPGTWTDESRHPDTQLNYANEFDLNIKGWLLNEPNYRLGLMAGYQESRYSFTARGGSYIYSSEEGFRDDIGSFPNGERAIGYKQRFKMPYIGLTGSYRYEDFELGGTFKYSGWVESSDNDEHYDPGKRITYRSKVKDQNYYSVAVNAGYYVTPNAKVYVEGAWNRVTNKKGNTSLYDHNNNTSDYSKNGAGIENYNFITTAGLKYTF | proteolysis cell outer membrane aspartic-type endopeptidase activity endopeptidase activity serine-type endopeptidase activity Escherichia coli 3D-structure Aspartyl protease Cell outer membrane Direct protein sequencing Hydrolase Membrane Protease Reference proteome Signal Transmembrane Transmembrane beta strand MRAKL... |
behavioral response to ethanol blood vessel remodeling chemical synaptic transmission dopamine catabolic process fear response glucose homeostasis homoiothermy leukocyte mediated immunity leukocyte migration locomotory behavior maternal behavior memory norepinephrine biosynthetic process octopamine biosynthetic process... | centriolar satellite; chromaffin granule lumen; chromaffin granule membrane; cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; intracellular membrane-bounded organelle; membrane; secretory granule lumen; secretory granule membrane; synapse; transport vesicle membrane | catalytic activity copper ion binding dopamine beta-monooxygenase activity L-ascorbic acid binding | Homo sapiens | 3D-structure Catecholamine biosynthesis Copper Cytoplasmic vesicle Direct protein sequencing Disease variant Disulfide bond Glycoprotein Membrane Metal-binding Monooxygenase Oxidoreductase Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix Vitamin C | MPALSRWASL | MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFG... | behavioral response to ethanol blood vessel remodeling chemical synaptic transmission dopamine catabolic process fear response glucose homeostasis homoiothermy leukocyte mediated immunity leukocyte migration locomotory behavior maternal behavior memory norepinephrine biosynthetic process octopamine biosynthetic process... |
positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway positive regulation of MAPK cascade response to stimulus visual perception | photoreceptor outer segment membrane; plasma membrane | 3',5'-cyclic-GMP phosphodiesterase activity cGMP binding spectrin binding | Mus musculus | Acetylation cGMP Hydrolase Reference proteome Sensory transduction Vision | MNLEPPKGEI | MNLEPPKGEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII | positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway positive regulation of MAPK cascade response to stimulus visual perception photoreceptor outer segment membrane; plasma membrane 3',5'-cyclic-GMP phosphodiesterase activity cGMP ... |
fatty acid biosynthetic process lipid oxidation oxylipin biosynthetic process | cytoplasm | linoleate 9S-lipoxygenase activity metal ion binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Glycine max | 3D-structure Cytoplasm Dioxygenase Fatty acid biosynthesis Fatty acid metabolism Iron Lipid biosynthesis Lipid metabolism Metal-binding Oxidoreductase Oxylipin biosynthesis Reference proteome | MLGGLLHRGH | MLGGLLHRGHKIKGTVVLMRKNVLHVNSVTSVGGIIGQGLDLVGSTLDTLTAFLGRPVSLQLISATKADANGKGKLGKATFLEGIITSLPTLGAGQSAFKINFEWDDGSGILGAFYIKNFMQTEFFLVSLTLEDIPNHGSIHFVCNSWIYNAKLFKSDRIFFANQTYLPSETPAPLVKYREEELHNLRGDGTGERKEWERVYDYDVYNDLGDPDKGENHARPVLGGNDTFPYPRRGRTGRKPTRKDPNSESRSNDVYLPRDEAFGHLKSSDFLTYGLKSVSQNVLPLLQSAFDLNFTPREFDSFDEVHGLYSGGIKLPTD... | fatty acid biosynthetic process lipid oxidation oxylipin biosynthetic process cytoplasm linoleate 9S-lipoxygenase activity metal ion binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Glycine max 3D-structure Cytoplasm Dioxygenase Fatty... |
photosynthetic electron transport chain | photosystem II reaction center; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II | electron transfer activity heme binding iron ion binding | Synechocystis sp. | 3D-structure Direct protein sequencing Electron transport Heme Iron Membrane Metal-binding Photosynthesis Photosystem II Reference proteome Thylakoid Transmembrane Transmembrane helix Transport | MSGTTGERPF | MSGTTGERPFSDIVTSIRYWVIHSITIPMLFIAGWLFVSTGLAYDAFGTPRPDEYFTQTRQELPILQERYDINQEIQEFNQ | photosynthetic electron transport chain photosystem II reaction center; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II electron transfer activity heme binding iron ion binding Synechocystis sp. 3D-structure Direct protein sequencing Electron transport Heme Iron Membrane Met... |
photosynthetic electron transport chain | photosystem II reaction center; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II | electron transfer activity heme binding identical protein binding iron ion binding | Synechocystis sp. | 3D-structure Direct protein sequencing Electron transport Heme Iron Membrane Metal-binding Photosynthesis Photosystem II Reference proteome Thylakoid Transmembrane Transmembrane helix Transport | MATQNPNQPV | MATQNPNQPVTYPIFTVRWLAVHTLAVPSVFFVGAIAAMQFIQR | photosynthetic electron transport chain photosystem II reaction center; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II electron transfer activity heme binding identical protein binding iron ion binding Synechocystis sp. 3D-structure Direct protein sequencing Electron transp... |
photosynthetic electron transport in photosystem II | photosystem II; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II | chlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity iron ion binding oxygen evolving activity | Synechocystis sp. | 3D-structure Chlorophyll Chromophore Electron transport Iron Magnesium Membrane Metal-binding Oxidoreductase Photosynthesis Photosystem II Reference proteome Thylakoid Transmembrane Transmembrane helix Transport | MTIAVGRAPV | MTIAVGRAPVERGWFDVLDDWLKRDRFVFIGWSGLLLFPCAFMALGGWLTGTTFVTSWYTHGLASSYLEGANFLTVAVSSPADAFGHSLLFLWGPEAQGNLTRWFQIGGLWPFVALHGAFGLIGFMLRQFEISRLVGIRPYNAIAFSGPIAVFVSVFLMYPLGQSSWFFAPSFGVAGIFRFILFLQGFHNWTLNPFHMMGVAGILGGALLCAIHGATVENTLFEDGEDSNTFRAFEPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSSVGIVGLALNLRAYDFVSQELRAAEDPEFETFYTKNIL... | photosynthetic electron transport in photosystem II photosystem II; plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II chlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity iron ion binding oxyge... |
photosynthetic electron transport in photosystem II | plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II | chlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity metal ion binding | Synechocystis sp. | 3D-structure Chlorophyll Chromophore Manganese Membrane Metal-binding Photosynthesis Photosystem II Reference proteome Thylakoid Transmembrane Transmembrane helix | MVTLSNTSMV | MVTLSNTSMVGGRDLPSTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWAGAMTLFEVAHFIPEKPMYEQGLILLPHIATLGWGVGPAGEVTDIFPFFVVGVLHLISSAVLGLGGIYHALRGPEVLEEYSSFFGYDWKDKNQMTNIIGYHLILLGCGALLLVFKAMFFGGVYDTWAPGGGDVRVITNPTLNPAIIFGYLLKAPFGGEGWIISVNNMEDIIGGHIWIGLICISGGIWHILTKPFGWARRALIWSGEAYLSYSLGALSLMGFIASVFVWFNNTAYPSEFYGPTGMEASQSQAFTFLVRDQRLGANIASAQG... | photosynthetic electron transport in photosystem II plasma membrane-derived thylakoid membrane; plasma membrane-derived thylakoid photosystem II chlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity metal ion binding Synechocystis sp. 3D... |
cellular response to magnesium ion cellular response to xenobiotic stimulus dephosphorylation fructose 6-phosphate metabolic process gluconeogenesis negative regulation of cell growth negative regulation of glycolytic process negative regulation of Ras protein signal transduction regulation of gluconeogenesis | cytoplasm; cytosol | AMP binding fructose 1,6-bisphosphate 1-phosphatase activity identical protein binding metal ion binding monosaccharide binding | Ovis aries | Acetylation Allosteric enzyme Carbohydrate metabolism Direct protein sequencing Gluconeogenesis Hydrolase Magnesium Metal-binding Phosphoprotein Reference proteome | MTDEAPFDTN | MTDEAPFDTNIVTVTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGTTNVTGDQVKKLDVLSNDLVVNVLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYKKISKDDPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSLNEGYAKDFDPALTEYVQRKKFPPDNSAPYGSRYVGSMVADVHRTLVYGGIFMYPADKKSPSGKLRLLYECDPMAYVIEKAGGMATTGKEAVLDIVPTDIHQKVPIILG... | cellular response to magnesium ion cellular response to xenobiotic stimulus dephosphorylation fructose 6-phosphate metabolic process gluconeogenesis negative regulation of cell growth negative regulation of glycolytic process negative regulation of Ras protein signal transduction regulation of gluconeogenesis cytoplasm... |
fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose metabolic process gluconeogenesis reactive oxygen species metabolic process sucrose biosynthetic process | cytoplasm; cytosol; periplasmic space | fructose 1,6-bisphosphate 1-phosphatase activity metal ion binding | Saccharomyces cerevisiae | 3D-structure Allosteric enzyme Carbohydrate metabolism Direct protein sequencing Hydrolase Magnesium Metal-binding Phosphoprotein Reference proteome Ubl conjugation | MPTLVNGPRR | MPTLVNGPRRDSTEGFDTDIITLPRFIIEHQKQFKNATGDFTLVLNALQFAFKFVSHTIRRAELVNLVGLAGASNFTGDQQKKLDVLGDEIFINAMRASGIIKVLVSEEQEDLIVFPTNTGSYAVCCDPIDGSSNLDAGVSVGTIASIFRLLPDSSGTINDVLRCGKEMVAACYAMYGSSTHLVLTLGDGVDGFTLDTNLGEFILTHPNLRIPPQKAIYSINEGNTLYWNETIRTFIEKVKQPQADNNNKPFSARYVGSMVADVHRTFLYGGLFAYPCDKKSPNGKLRLLYEAFPMAFLMEQAGGKAVNDRGERILDLVP... | fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose metabolic process gluconeogenesis reactive oxygen species metabolic process sucrose biosynthetic process cytoplasm; cytosol; periplasmic space fructose 1,6-bisphosphate 1-phosphatase activity metal ion binding Saccharomyces cere... |
microtubule-based process | cytoplasm; microtubule | GTP binding hydrolase activity metal ion binding structural constituent of cytoskeleton | Chlamydomonas reinhardtii | 3D-structure Acetylation Cytoplasm Cytoskeleton GTP-binding Hydrolase Magnesium Metal-binding Microtubule Nucleotide-binding | MREVISIHIG | MREVISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTIGGGDDAFNTFFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLALDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRSLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNAAFEPASMMVKCDPRHGKYMACCLMYR... | microtubule-based process cytoplasm; microtubule GTP binding hydrolase activity metal ion binding structural constituent of cytoskeleton Chlamydomonas reinhardtii 3D-structure Acetylation Cytoplasm Cytoskeleton GTP-binding Hydrolase Magnesium Metal-binding Microtubule Nucleotide-binding MREVISIHIG MREVISIHIGQAGIQVGNACW... |
microtubule-based process | cytoplasm; microtubule | GTP binding hydrolase activity metal ion binding structural constituent of cytoskeleton | Chlamydomonas reinhardtii | Acetylation Cytoplasm Cytoskeleton GTP-binding Hydrolase Magnesium Metal-binding Microtubule Nucleotide-binding | MREVISIHIG | MREVISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTIGGGDDAFNTFFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLALDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRSLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNAAFEPASMMVKCDPLHGKYMACCLMYR... | microtubule-based process cytoplasm; microtubule GTP binding hydrolase activity metal ion binding structural constituent of cytoskeleton Chlamydomonas reinhardtii Acetylation Cytoplasm Cytoskeleton GTP-binding Hydrolase Magnesium Metal-binding Microtubule Nucleotide-binding MREVISIHIG MREVISIHIGQAGIQVGNACWELYCLEHGIQPDG... |
epithelial cell differentiation glutathione metabolic process xenobiotic metabolic process | cytosol; extracellular exosome | glutathione transferase activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Reference proteome Transferase | MAEKPKLHYS | MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF | epithelial cell differentiation glutathione metabolic process xenobiotic metabolic process cytosol; extracellular exosome glutathione transferase activity Homo sapiens 3D-structure Acetylation Cytoplasm Direct protein sequencing Reference proteome Transferase MAEKPKLHYS MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGY... |
defense response to Gram-positive bacterium humoral immune response inflammatory response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of cell population proliferation positive regulation of chronic inflammatory response to antigenic... | extracellular space; plasma membrane | cytokine activity tumor necrosis factor receptor binding | Mus musculus | Cytokine Glycoprotein Membrane Reference proteome Secreted Signal | MTLLGRLHLL | MTLLGRLHLLRVLGTPPVFLLGLLLALPLGAQGLSGVRFSAARTAHPLPQKHLTHGILKPAAHLVGYPSKQNSLLWRASTDRAFLRHGFSLSNNSLLIPTSGLYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSSQYPFHVPLLSAQKSVYPGLQGPWVRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSSVFFGAFAL | defense response to Gram-positive bacterium humoral immune response inflammatory response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of cell population proliferation positive regulation of chronic inflammatory response to antigenic... |
detection of chemical stimulus involved in sensory perception of bitter taste | cytoplasm; extracellular space; vesicle | cysteine-type endopeptidase inhibitor activity | Homo sapiens | Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor | MAWPLCTLLL | MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA | detection of chemical stimulus involved in sensory perception of bitter taste cytoplasm; extracellular space; vesicle cysteine-type endopeptidase inhibitor activity Homo sapiens Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor MAWPLCTLLL MAWPLCTLLLL... |
proteolysis | extracellular space | serine-type endopeptidase activity | Yarrowia lipolytica | Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Zymogen | MKLATAFTIL | MKLATAFTILTAVLAAPLAAPAPAPDAAPAAVPEGPAAAAYSSILSVVAKQSKKFKHHKRDLDEKDQFIVVFDSSATVDQIASEIQKLDSLVDEDSSNGITSALDLPVYTDGSGFLGFVGKFNSTIVDKLKESSVLTVEPDTIVSLPEIPASSNAKRAIQTTPVTQWGLSRISHKKAQTGNYAYVRETVGKHPTVSYVVDSGIRTTHSEFGGRAVWGANFADTQNADLLGHGTHVAGTVGGKTYGVDANTKLVAVKVFAGRSAALSVINQGFTWALNDYISKRDTLPRGVLNFSGGGPKSASQDALWSRATQEGLLVAIA... | proteolysis extracellular space serine-type endopeptidase activity Yarrowia lipolytica Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Zymogen MKLATAFTIL MKLATAFTILTAVLAAPLAAPAPAPDAAPAAVPEGPAAAAYSSILSVVAKQSKKFKHHKRDLDEKDQF... |
pexophagy protein catabolic process in the vacuole proteolysis sporulation resulting in formation of a cellular spore | extracellular space; fungal-type vacuole; fungal-type vacuole lumen | serine-type endopeptidase activity | Saccharomyces cerevisiae | Amyloid Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Prion Protease Reference proteome Serine protease Signal Vacuole Zymogen | MKLENTLFTL | MKLENTLFTLGALGSISAALVIPNLENAADHHELINKEDHHERPRKVEFTKDDDEEPSDSEDKEHGKFHKKGRKGQDKESPEFNGKRASGSHGSAHEGGKGMKPKHESSNDDDNDDKKKKPHHKGGCHENKVEEKKMKGKKVKGKKHHEKTLEKGRHHNRLAPLVSTAQFNPDAISKIIPNRYIIVFKRGAPQEEIDFHKENVQQAQLQSVENLSAEDAFFISTKDTSLSTSEAGGIQDSFNIDNLFSGYIGYFTQEIVDLIRQNPLVDFVERDSIVEATEFDTQNSAPWGLARISHRERLNLGSFNKYLYDDDAGRGVT... | pexophagy protein catabolic process in the vacuole proteolysis sporulation resulting in formation of a cellular spore extracellular space; fungal-type vacuole; fungal-type vacuole lumen serine-type endopeptidase activity Saccharomyces cerevisiae Amyloid Direct protein sequencing Disulfide bond Glycoprotein Hydrolase P... |
response to herbicide response to oxidative stress response to reactive oxygen species response to xenobiotic stimulus | mitochondrial matrix; mitochondrion | manganese ion binding superoxide dismutase activity | Zea mays | Manganese Metal-binding Mitochondrion Oxidoreductase Reference proteome Transit peptide | MALRTLASKK | MALRTLASKKVLSFPFGGAGRPLAAAASARGVTTVTLPDLSYDFGALEPAISGEIMRLHHQKHHATYVANYNKALEQLETAVSKGDASAVVQLQAAIKFNGGGHVNHSIFWKNLKPISEGGGEPPHGKLGWAIDEDFGSFEALVKKMNAEGAALQGSGWVWLALDKEAKKVSVETTANQDPLVTKGASLVPLLGIDVWEHAYYLQYKNVRPDYLNNIWKVMNWKYAGEVYENVLA | response to herbicide response to oxidative stress response to reactive oxygen species response to xenobiotic stimulus mitochondrial matrix; mitochondrion manganese ion binding superoxide dismutase activity Zea mays Manganese Metal-binding Mitochondrion Oxidoreductase Reference proteome Transit peptide MALRTLASKK MALRT... |
mRNA 5'-splice site recognition mRNA splicing, via spliceosome spliceosomal snRNP assembly | Cajal body; commitment complex; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2-type prespliceosome | mRNA binding pre-mRNA 5'-splice site binding protein homodimerization activity RNA binding single-stranded RNA binding zinc ion binding | Homo sapiens | 3D-structure Acetylation Metal-binding Nucleus Phosphoprotein Reference proteome Ribonucleoprotein RNA-binding Zinc Zinc-finger | MPKFYCDYCD | MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR | mRNA 5'-splice site recognition mRNA splicing, via spliceosome spliceosomal snRNP assembly Cajal body; commitment complex; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2-type prespliceosome mRNA binding pre-mRNA 5'-splice site binding protein homodimerization activity RNA binding single-stranded RNA binding z... |
collagen catabolic process extracellular matrix disassembly extracellular matrix organization membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis positive regulation of cell migration proteolysis | extracellular exosome; extracellular matrix; extracellular region; extracellular space | endopeptidase activity metalloendopeptidase activity metallopeptidase activity serine-type endopeptidase activity zinc ion binding | Homo sapiens | 3D-structure Calcium Collagen degradation Direct protein sequencing Extracellular matrix Hydrolase Metal-binding Metalloprotease Protease Reference proteome Secreted Signal Zinc Zymogen | MRLTVLCAVC | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK | collagen catabolic process extracellular matrix disassembly extracellular matrix organization membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis positive regulation of cell migration proteolysis extracellular exosome; extracellular matrix; extracellular region; extracellular space... |
collagen catabolic process extracellular matrix disassembly extracellular matrix organization proteolysis | extracellular matrix; extracellular region; extracellular space | metalloendopeptidase activity serine-type endopeptidase activity zinc ion binding | Homo sapiens | 3D-structure Calcium Collagen degradation Disulfide bond Extracellular matrix Hydrolase Metal-binding Metalloprotease Protease Reference proteome Repeat Secreted Signal Zinc Zymogen | MMHLAFLVLL | MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWN... | collagen catabolic process extracellular matrix disassembly extracellular matrix organization proteolysis extracellular matrix; extracellular region; extracellular space metalloendopeptidase activity serine-type endopeptidase activity zinc ion binding Homo sapiens 3D-structure Calcium Collagen degradation Disulfide bon... |
axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regula... | axon; axon hillock; axon initial segment; dendrite; extracellular space; GABA-ergic synapse; neuronal cell body; perikaryon; terminal bouton | hormone activity neuropeptide hormone activity peptide hormone receptor binding receptor ligand activity | Mus musculus | Amidation Cleavage on pair of basic residues Hormone Reference proteome Secreted Signal Sulfation | MKSGVCLCVV | MKSGVCLCVVMAVLAAGALAQPVVPAEATDPVEQRAQEAPRRQLRAVLRTDGEPRARLGALLARYIQQVRKAPSGRMSVLKNLQSLDPSHRISDRDYMGWMDFGRRSAEDYEYPS | axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regula... |
bone mineralization calcium ion homeostasis cellular homeostasis cellular response to organic cyclic compound cementum mineralization dephosphorylation developmental process involved in reproduction endochondral ossification futile creatine cycle inhibition of non-skeletal tissue mineralization phosphate ion homeostasi... | extracellular matrix; extracellular membrane-bounded organelle; extracellular space; mitochondrial intermembrane space; mitochondrial membrane; plasma membrane; side of membrane | ADP phosphatase activity alkaline phosphatase activity ATP hydrolysis activity calcium ion binding inorganic diphosphate phosphatase activity phosphoamidase activity phosphoethanolamine phosphatase activity pyridoxal phosphatase activity pyrophosphatase activity | Mus musculus | Biomineralization Calcium Cell membrane Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Magnesium Membrane Metal-binding Mitochondrion Phosphoprotein Reference proteome Signal Zinc | MISPFLVLAI | MISPFLVLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRIL... | bone mineralization calcium ion homeostasis cellular homeostasis cellular response to organic cyclic compound cementum mineralization dephosphorylation developmental process involved in reproduction endochondral ossification futile creatine cycle inhibition of non-skeletal tissue mineralization phosphate ion homeostasi... |
DNA damage response N-acetylglucosamine transport phosphoenolpyruvate-dependent sugar phosphotransferase system phosphorylation | organelle inner membrane; plasma membrane | kinase activity metal ion binding N-acetylglucosamine transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity protein-phosphocysteine-sugar phosphotransferase activity | Escherichia coli | Cell inner membrane Cell membrane Formylation Kinase Membrane Metal-binding Phosphoprotein Phosphotransferase system Reference proteome Sugar transport Transferase Transmembrane Transmembrane helix Transport Zinc | MNILGFFQRL | MNILGFFQRLGRALQLPIAVLPVAALLLRFGQPDLLNVAFIAQAGGAIFDNLALIFAIGVASSWSKDSAGAAALAGAVGYFVLTKAMVTINPEINMGVLAGIITGLVGGAAYNRWSDIKLPDFLSFFGGKRFVPIATGFFCLVLAAIFGYVWPPVQHAIHAGGEWIVSAGALGSGIFGFINRLLIPTGLHQVLNTIAWFQIGEFTNAAGTVFHGDINRFYAGDGTAGMFMSGFFPIMMFGLPGAALAMYFAAPKERRPMVGGMLLSVAVTAFLTGVTEPLEFLFMFLAPLLYLLHALLTGISLFVATLLGIHAGFSFSAG... | DNA damage response N-acetylglucosamine transport phosphoenolpyruvate-dependent sugar phosphotransferase system phosphorylation organelle inner membrane; plasma membrane kinase activity metal ion binding N-acetylglucosamine transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activ... |
cell differentiation innate immune response phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway | centrosome; cytosol; extrinsic component of cytoplasmic side of plasma membrane; Golgi apparatus | ATP binding enzyme binding non-membrane spanning protein tyrosine kinase activity phosphotyrosine residue binding signaling receptor binding transmembrane transporter binding | Gallus gallus | ATP-binding Cell membrane Cytoplasm Cytoskeleton Kinase Lipoprotein Membrane Myristate Nucleotide-binding Palmitate Phosphoprotein Reference proteome SH2 domain SH3 domain Transferase Tyrosine-protein kinase | MGCIKSKEDK | MGCIKSKEDKGPAMKYRTDNTPEPISSHVSHYGSDSSQATQSPAIKGSAVNFNSHSMTPFGGPSGMTPFGGASSSFSAVPSPYPSTLTGGVTVFVALYDYEARTTDDLSFKKGERFQIINNTEGDWWEARSIATGKTGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFESLQKLVKHYREHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQ... | cell differentiation innate immune response phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway centrosome; cytosol; extrinsic component of cytoplasmic side of plasma membrane; Golgi apparatus ATP binding enzyme binding non-membrane spanning protein tyrosine kinase activity phosphotyrosine ... |
5-phosphoribose 1-diphosphate biosynthetic process AMP biosynthetic process animal organ regeneration pentose-phosphate shunt phosphorylation purine nucleotide biosynthetic process | cytoplasm; cytosol; protein-containing complex; ribose phosphate diphosphokinase complex | ADP binding AMP binding ATP binding carbohydrate binding GDP binding identical protein binding kinase activity magnesium ion binding protein homodimerization activity ribose phosphate diphosphokinase activity | Rattus norvegicus | ATP-binding Direct protein sequencing Kinase Magnesium Metal-binding Nucleotide biosynthesis Nucleotide-binding Reference proteome Transferase | MPNIVLFSGS | MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL | 5-phosphoribose 1-diphosphate biosynthetic process AMP biosynthetic process animal organ regeneration pentose-phosphate shunt phosphorylation purine nucleotide biosynthetic process cytoplasm; cytosol; protein-containing complex; ribose phosphate diphosphokinase complex ADP binding AMP binding ATP binding carbohydrate b... |
citrate metabolic process propionate metabolic process, methylcitrate cycle regulation of sporulation tricarboxylic acid cycle | cytosol | 2-methylisocitrate dehydratase activity 4 iron, 4 sulfur cluster binding aconitate hydratase activity iron-responsive element binding metal ion binding mRNA 3'-UTR binding mRNA binding | Bacillus subtilis | Direct protein sequencing Iron Iron-sulfur Lyase Metal-binding Reference proteome RNA-binding Tricarboxylic acid cycle | MANEQKTAAK | MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSKLPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVPAVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERNAERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLALKVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGAT... | citrate metabolic process propionate metabolic process, methylcitrate cycle regulation of sporulation tricarboxylic acid cycle cytosol 2-methylisocitrate dehydratase activity 4 iron, 4 sulfur cluster binding aconitate hydratase activity iron-responsive element binding metal ion binding mRNA 3'-UTR binding mRNA binding ... |
actin cytoskeleton organization antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide chemokine-mediated signaling pathway chemotaxis G protein-coupled receptor signaling pathway inflammatory response intracellular signal transduction negative regulation of cell... | extracellular region; extracellular space; specific granule lumen; tertiary granule lumen | chemokine activity CXCR chemokine receptor binding enzyme activator activity growth factor activity signaling receptor binding | Homo sapiens | 3D-structure Cytokine Direct protein sequencing Disulfide bond Growth factor Inflammatory response Reference proteome Secreted Signal | MARAALSAAP | MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN | actin cytoskeleton organization antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide chemokine-mediated signaling pathway chemotaxis G protein-coupled receptor signaling pathway inflammatory response intracellular signal transduction negative regulation of cell... |
isoleucine biosynthetic process response to herbicide valine biosynthetic process | acetolactate synthase complex; chloroplast | acetolactate synthase activity flavin adenine dinucleotide binding magnesium ion binding thiamine pyrophosphate binding | Nicotiana tabacum | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Chloroplast Disulfide bond FAD Flavoprotein Herbicide resistance Magnesium Metal-binding Plastid Reference proteome Thiamine pyrophosphate Transferase Transit peptide | MAAAAPSPSS | MAAAAPSPSSSAFSKTLSPSSSTSSTLLPRSTFPFPHHPHKTTPPPLHLTHTHIHIHSQRRRFTISNVISTNQKVSQTEKTETFVSRFAPDEPRKGSDVLVEALEREGVTDVFAYPGGASMEIHQALTRSSIIRNVLPRHEQGGVFAAEGYARATGFPGVCIATSGPGATNLVSGLADALLDSVPIVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRVVREAFFLARSGRPGPILIDVPKDIQQQLVIPDWDQPMRLPGYMSRLPKLPNEMLLEQIVRLISESKKPVLYVGGGCSQSSEDLRRFVEL... | isoleucine biosynthetic process response to herbicide valine biosynthetic process acetolactate synthase complex; chloroplast acetolactate synthase activity flavin adenine dinucleotide binding magnesium ion binding thiamine pyrophosphate binding Nicotiana tabacum Amino-acid biosynthesis Branched-chain amino acid biosynt... |
bacterial-type flagellum-dependent cell motility bacterial-type flagellum-dependent swarming motility chemotaxis proton transmembrane transport | bacterial-type flagellum; bacterial-type flagellum stator complex; plasma membrane | proton channel activity | Escherichia coli | Cell inner membrane Cell membrane Chemotaxis Flagellar rotation Hydrogen ion transport Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport | MLILLGYLVV | MLILLGYLVVLGTVFGGYLMTGGSLGALYQPAELVIIAGAGIGSFIVGNNGKAIKGTLKALPLLFRRSKYTKAMYMDLLALLYRLMAKSRQMGMFSLERDIENPRESEIFASYPRILADSVMLDFIVDYLRLIISGHMNTFEIEALMDEEIETHESEAEVPANSLALVGDSLPAFGIVAAVMGVVHALGSADRPAAELGALIAHAMVGTFLGILLAYGFISPLATVLRQKSAETSKMMQCVKVTLLSNLNGYAPPIAVEFGRKTLYSSERPSFIELEEHVRAVKNPQQQTTTEEA | bacterial-type flagellum-dependent cell motility bacterial-type flagellum-dependent swarming motility chemotaxis proton transmembrane transport bacterial-type flagellum; bacterial-type flagellum stator complex; plasma membrane proton channel activity Escherichia coli Cell inner membrane Cell membrane Chemotaxis Flagell... |
gluconeogenesis isoleucine biosynthetic process L-serine catabolic process lipid metabolic process protein-containing complex assembly pyruvate biosynthetic process response to amino acid response to cobalamin response to nutrient levels threonine catabolic process | cytoplasm | L-serine ammonia-lyase activity L-threonine ammonia-lyase activity protein homodimerization activity pyridoxal phosphate binding | Rattus norvegicus | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Gluconeogenesis Lipid metabolism Lyase Pyridoxal phosphate Reference proteome | MAAQESLHVK | MAAQESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCKHFVCSSVVQIWGSRMRGRSHSGDEQPHVRSQALLPDTPSPLTAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQLAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLREVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKITSVAKALGVNTVGAQTLKLFYEHPIFSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAVYSGVVCR... | gluconeogenesis isoleucine biosynthetic process L-serine catabolic process lipid metabolic process protein-containing complex assembly pyruvate biosynthetic process response to amino acid response to cobalamin response to nutrient levels threonine catabolic process cytoplasm L-serine ammonia-lyase activity L-threonine ... |
chaperone cofactor-dependent protein refolding protein unfolding protein-containing complex assembly response to heat | cytoplasm; cytosol; protein-containing complex | adenyl-nucleotide exchange factor activity protein domain specific binding protein homodimerization activity protein-folding chaperone binding unfolded protein binding | Escherichia coli | 3D-structure Chaperone Cytoplasm Reference proteome Stress response | MSSKEQKTPE | MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKVANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA | chaperone cofactor-dependent protein refolding protein unfolding protein-containing complex assembly response to heat cytoplasm; cytosol; protein-containing complex adenyl-nucleotide exchange factor activity protein domain specific binding protein homodimerization activity protein-folding chaperone binding unfolded pro... |
glucose metabolic process | cytosol; membrane | formate C-acetyltransferase activity | Escherichia coli | 3D-structure Acetylation Acyltransferase Carbohydrate metabolism Cytoplasm Direct protein sequencing Glucose metabolism Organic radical Reference proteome Transferase | MSELNEKLAT | MSELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFLAGATEATTTLWDKVMEGVKLENRTHAPVDFDTAVASTITSHDAGYINKQLEKIVGLQTEAPLKRALIPFGGIKMIEGSCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYTPDILRCRKSGVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQFTSLQADLENGVNLEQTIRLREEIAEQHRALGQMKEMAAKYGYDISGPATNAQEAIQWTYFGYLAAVKSQNGAAMSFGRTSTFLDVYIERDLKAGKITEQEAQEMVDHLVMKLRMVRFLR... | glucose metabolic process cytosol; membrane formate C-acetyltransferase activity Escherichia coli 3D-structure Acetylation Acyltransferase Carbohydrate metabolism Cytoplasm Direct protein sequencing Glucose metabolism Organic radical Reference proteome Transferase MSELNEKLAT MSELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFL... |
positive regulation of DNA-templated transcription regulation of DNA-templated transcription rhamnose metabolic process | cytoplasm | DNA-binding transcription factor activity sequence-specific DNA binding | Escherichia coli | Activator Cytoplasm DNA-binding Reference proteome Repeat Rhamnose metabolism Transcription Transcription regulation | MTVLHSVDFF | MTVLHSVDFFPSGNASVAIEPRLPQADFPEHHHDFHEIVIVEHGTGIHVFNGQPYTITGGTVCFVRDHDRHLYEHTDNLCLTNVLYRSPDRFQFLAGLNQLLPQELDGQYPSHWRVNHSVLQQVRQLVAQMEQQEGENDLPSTASREILFMQLLLLLRKSSLQENLENSASRLNLLLAWLEDHFADEVNWDAVADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLMKARHLLRHSEASVTDIAYRCGFSDSNHFSTLFRREFNWSPRDIRQGRDGFLQ | positive regulation of DNA-templated transcription regulation of DNA-templated transcription rhamnose metabolic process cytoplasm DNA-binding transcription factor activity sequence-specific DNA binding Escherichia coli Activator Cytoplasm DNA-binding Reference proteome Repeat Rhamnose metabolism Transcription Transcrip... |
apoptotic process cell-cell adhesion myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process... | collagen-containing extracellular matrix; cytoplasm; cytosol; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; galectin complex | carbohydrate binding laminin binding RNA binding | Homo sapiens | 3D-structure Acetylation Apoptosis Cytoplasm Direct protein sequencing Extracellular matrix Lectin Phosphoprotein Reference proteome Secreted | MACGLVASNL | MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD | apoptotic process cell-cell adhesion myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process... |
modulation of host virulence by virus negative regulation of translation | extracellular region | rRNA N-glycosylase activity toxin activity | Escherichia phage 933W | 3D-structure Disulfide bond Hydrolase Modulation of host virulence by virus Protein synthesis inhibitor Reference proteome Secreted Signal Toxin Viral exotoxin Virulence | MKCILFKWVL | MKCILFKWVLCLLLGFSSVSYSREFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSVSVINHTPPGSYFAVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHISVPGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTMTRDASRAVLRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTLNWGRISNVLPEYRGEDGVRVGRISFNNISAILGTVAVILNCHHQGARSVRAVNEESQPECQITGDRPVIKINNTLWESNTAAAFLNRKSQFLYTTGK | modulation of host virulence by virus negative regulation of translation extracellular region rRNA N-glycosylase activity toxin activity Escherichia phage 933W 3D-structure Disulfide bond Hydrolase Modulation of host virulence by virus Protein synthesis inhibitor Reference proteome Secreted Signal Toxin Viral exotoxin ... |
proteolysis | plasma membrane | endopeptidase activity identical protein binding serine-type endopeptidase activity | Escherichia coli | 3D-structure Cell inner membrane Cell membrane Direct protein sequencing Hydrolase Membrane Protease Reference proteome Serine protease Transmembrane Transmembrane helix | MLMITSFANP | MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK | proteolysis plasma membrane endopeptidase activity identical protein binding serine-type endopeptidase activity Escherichia coli 3D-structure Cell inner membrane Cell membrane Direct protein sequencing Hydrolase Membrane Protease Reference proteome Serine protease Transmembrane Transmembrane helix MLMITSFANP MLMITSFANP... |
glycerol metabolic process lipid metabolic process | periplasmic space | calcium ion binding glycerophosphodiester phosphodiesterase activity metal ion binding | Escherichia coli | 3D-structure Calcium Direct protein sequencing Glycerol metabolism Hydrolase Metal-binding Periplasm Reference proteome Signal | MKLTLKNLSM | MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDNLVVLHDHYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMELNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKL... | glycerol metabolic process lipid metabolic process periplasmic space calcium ion binding glycerophosphodiester phosphodiesterase activity metal ion binding Escherichia coli 3D-structure Calcium Direct protein sequencing Glycerol metabolism Hydrolase Metal-binding Periplasm Reference proteome Signal MKLTLKNLSM MKLTLKNLS... |
cell migration mitotic cytokinesis myosin filament assembly sorocarp development | actomyosin; extracellular matrix; myosin II complex | calcium ion binding cytoskeletal motor activator activity microfilament motor activity myosin heavy chain binding | Dictyostelium discoideum | Calcium Metal-binding Motor protein Myosin Reference proteome Repeat | MSASADQIQE | MSASADQIQECFSIFDKDNDGKVSVEDIGACLRSLGKSPTMADIEALKTEIGAKEFDINTLKSIYKKPNIKTPQEQQKEMLDAFKALDKEGHGTIQGAELRQLLTTLGDYLSTAEVDELFKEISVDSTTGAVSYASLVNTIVSGYPLGGF | cell migration mitotic cytokinesis myosin filament assembly sorocarp development actomyosin; extracellular matrix; myosin II complex calcium ion binding cytoskeletal motor activator activity microfilament motor activity myosin heavy chain binding Dictyostelium discoideum Calcium Metal-binding Motor protein Myosin Refer... |
angiogenesis cellular response to epidermal growth factor stimulus cellular response to leukemia inhibitory factor cellular response to lipopolysaccharide endocytosis negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway negative regulation of translation positive regulation... | cell cortex; cell surface; chromosome; cornified envelope; cytoplasmic ribonucleoprotein granule; dense fibrillar component; fibrillar center; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex | calcium ion binding DNA topoisomerase binding ErbB-4 class receptor binding histone binding identical protein binding insulin receptor substrate binding laminin binding mRNA 5'-UTR binding PH domain binding RNA binding rRNA primary transcript binding selenocysteine insertion sequence binding sequence-specific DNA bindi... | Mus musculus | Acetylation Cytoplasm Direct protein sequencing DNA-binding Isopeptide bond Methylation Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Ubl conjugation | MVKLAKAGKT | MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAVATPAKKNITPAKVIPTPGKKGAAQAKALVPTPGKKGAATPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDDEEEDEFEPPIVKGVKPAKAAPAAPASEDEEDDEDEDDEEDDDEEEEDDSEEEVMEITTAKGKKTPAKVVPMKAKSVAEEEDDEEEDEDDEDEDDEEEDDEDDDEEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKVEGSEPTTPFNLFIGNLNPNK... | angiogenesis cellular response to epidermal growth factor stimulus cellular response to leukemia inhibitory factor cellular response to lipopolysaccharide endocytosis negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway negative regulation of translation positive regulation... |
canonical glycolysis cellular response to hypoxia epithelial cell differentiation gluconeogenesis glyceraldehyde-3-phosphate biosynthetic process glycolytic process negative regulation of angiogenesis phosphorylation plasminogen activation | cytoplasm; cytosol; extracellular space; membrane raft | ADP binding ATP binding phosphoglycerate kinase activity protein-disulfide reductase (NAD(P)) activity | Mus musculus | 3D-structure Acetylation ATP-binding Cytoplasm Direct protein sequencing Glycolysis Hydroxylation Kinase Nucleotide-binding Phosphoprotein Reference proteome Transferase | MSLSNKLTLD | MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGPEVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTES... | canonical glycolysis cellular response to hypoxia epithelial cell differentiation gluconeogenesis glyceraldehyde-3-phosphate biosynthetic process glycolytic process negative regulation of angiogenesis phosphorylation plasminogen activation cytoplasm; cytosol; extracellular space; membrane raft ADP binding ATP binding p... |
BMP signaling pathway cartilage development cell morphogenesis DNA replication exit from mitosis gene expression generation of neurons glial cell fate specification glial cell proliferation limb morphogenesis neural precursor cell proliferation neurogenesis neuron fate specification positive regulation of DNA-templated... | nucleus | chromatin binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Rattus norvegicus | Activator Direct protein sequencing DNA replication DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MYSPLCLTQD | MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSP... | BMP signaling pathway cartilage development cell morphogenesis DNA replication exit from mitosis gene expression generation of neurons glial cell fate specification glial cell proliferation limb morphogenesis neural precursor cell proliferation neurogenesis neuron fate specification positive regulation of DNA-templated... |
amino acid metabolic process dihydrobiopterin metabolic process L-phenylalanine catabolic process tetrahydrobiopterin biosynthetic process | cytoplasm; cytosol; extracellular exosome | 6,7-dihydropteridine reductase activity electron transfer activity NADH binding NADPH binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Direct protein sequencing Disease variant NADP Oxidoreductase Phenylketonuria Reference proteome Tetrahydrobiopterin biosynthesis | MAAAAAAGEA | MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF | amino acid metabolic process dihydrobiopterin metabolic process L-phenylalanine catabolic process tetrahydrobiopterin biosynthetic process cytoplasm; cytosol; extracellular exosome 6,7-dihydropteridine reductase activity electron transfer activity NADH binding NADPH binding Homo sapiens 3D-structure Acetylation Alterna... |
chromatin remodeling flagellated sperm motility heterochromatin formation negative regulation of DNA-templated transcription nucleosome disassembly positive regulation of protein processing sexual reproduction single strand break repair sperm DNA condensation sperm DNA decondensation spermatid development spermatid nuc... | male germ cell nucleus; nucleosome; nucleus | DNA binding | Homo sapiens | Chromosome Developmental protein Differentiation DNA-binding Nucleosome core Nucleus Phosphoprotein Reference proteome Spermatogenesis | MSTSRKLKSH | MSTSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRGDDANRNYRSHL | chromatin remodeling flagellated sperm motility heterochromatin formation negative regulation of DNA-templated transcription nucleosome disassembly positive regulation of protein processing sexual reproduction single strand break repair sperm DNA condensation sperm DNA decondensation spermatid development spermatid nuc... |
photosynthetic electron transport in photosystem II | photosystem II; plasma membrane; plasma membrane light-harvesting complex | bacteriochlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity metal ion binding | Chloroflexus aurantiacus | Bacteriochlorophyll Cell membrane Chlorophyll Chromophore Direct protein sequencing Electron transport Iron Magnesium Membrane Metal-binding Photosynthesis Reaction center Reference proteome Transmembrane Transmembrane helix Transport | MATINMTPGD | MATINMTPGDLELGRDRGRIGKPIEIPLLENFGFDSQLGPFYLGFWNAVAYITGGIFTFIWLMVMFAQVNYNPVAFAKYFVVLQIDPPSSRYGLSFPPLNEGGWWLIATFFLTVSIFAWYMHIYTRAKALGIKPYLAYGFTGAIALYLVIYIIRPVWMGDWSEAPAHGIKALLDWTNNVSVRYGNFYYNPFHMLSIFFLLGSTLLLAMHAGTIWALEKYAAHEEWNEIQAPGTGTERAQLFWRWCMGFNANAYSIHLWAFWFAWLCGITGALGVFFSMPDFVNNWFQWGIEAGINYPQGPTPPVSLP | photosynthetic electron transport in photosystem II photosystem II; plasma membrane; plasma membrane light-harvesting complex bacteriochlorophyll binding electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity metal ion binding Chloroflexus aurantiacus Bacter... |
folic acid biosynthetic process nucleobase-containing compound metabolic process tetrahydrofolate interconversion | cytosol; mitochondrion | ATP binding formate-tetrahydrofolate ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity | Saccharomyces cerevisiae | ATP-binding Direct protein sequencing Hydrolase Ligase Mitochondrion Multifunctional enzyme NADP Nucleotide-binding One-carbon metabolism Oxidoreductase Reference proteome Transit peptide | MLSRLSLLSN | MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAA... | folic acid biosynthetic process nucleobase-containing compound metabolic process tetrahydrofolate interconversion cytosol; mitochondrion ATP binding formate-tetrahydrofolate ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity Saccharomyces cerevisiae... |
translational elongation | cytoplasm; nucleus | GTP binding GTPase activity translation elongation factor activity | Cricetulus griseus | Acetylation ADP-ribosylation Cytoplasm Elongation factor GTP-binding Hydrolase Isopeptide bond Methylation Nucleotide-binding Nucleus Phosphoprotein Protein biosynthesis Ubl conjugation | MVNFTVDQIR | MVNFTVDQIRAIMDKEANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDPIMNFRKEETAKLIEKLD... | translational elongation cytoplasm; nucleus GTP binding GTPase activity translation elongation factor activity Cricetulus griseus Acetylation ADP-ribosylation Cytoplasm Elongation factor GTP-binding Hydrolase Isopeptide bond Methylation Nucleotide-binding Nucleus Phosphoprotein Protein biosynthesis Ubl conjugation MVN... |
chaperone cofactor-dependent protein refolding determination of adult lifespan protein refolding response to heat retrograde transport, endosome to Golgi | cytoplasm; cytosol; nucleus; plasma membrane | ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone heat shock protein binding protein folding chaperone | Caenorhabditis elegans | 3D-structure ATP-binding Nucleotide-binding Reference proteome Stress response | MSKHNAVGID | MSKHNAVGIDLGTTYSCVGVFMHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFDDPAVQSDMKHWPFKVISAEGAKPKVQVEYKGENKIFTPEEISSMVLLKMKETAEAFLGTTVKDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKKGHGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFCAEFKRKHKKDLASNPRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTNITRARFEELCADLFRSTMDPVEK... | chaperone cofactor-dependent protein refolding determination of adult lifespan protein refolding response to heat retrograde transport, endosome to Golgi cytoplasm; cytosol; nucleus; plasma membrane ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone heat shock protein binding protein folding ch... |
cell differentiation cellular response to calcium ion decidualization embryonic process involved in female pregnancy in utero embryonic development labyrinthine layer blood vessel development osteoblast differentiation osteoblast proliferation osteoclast differentiation osteoclast proliferation positive regulation of c... | nucleoplasm; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcr... | Mus musculus | Acetylation DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MCTKMEQPFY | MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLADPYRGLKGPGARGPGPEGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGTGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASGGPQAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPPFAGGHPAQLGLSRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSAAGLLREQVAQ... | cell differentiation cellular response to calcium ion decidualization embryonic process involved in female pregnancy in utero embryonic development labyrinthine layer blood vessel development osteoblast differentiation osteoblast proliferation osteoclast differentiation osteoclast proliferation positive regulation of c... |
fatty acid transport lipid homeostasis retinoic acid biosynthetic process vitamin A metabolic process | cytosol; lipid droplet; nucleoplasm; nucleus | all-trans-retinol binding fatty acid binding retinal binding retinoid binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Lipid droplet Methylation Reference proteome Retinol-binding Transport Vitamin A | MPVDFTGYWK | MPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQ | fatty acid transport lipid homeostasis retinoic acid biosynthetic process vitamin A metabolic process cytosol; lipid droplet; nucleoplasm; nucleus all-trans-retinol binding fatty acid binding retinal binding retinoid binding Homo sapiens 3D-structure Alternative splicing Cytoplasm Lipid droplet Methylation Reference pr... |
adenylate cyclase-activating G protein-coupled receptor signaling pathway cardiac muscle cell proliferation cellular response to glucagon stimulus female meiotic nuclear division heart development mesoderm formation negative regulation of activated T cell proliferation negative regulation of gene expression negative re... | cAMP-dependent protein kinase complex; centrosome; cytoplasm; cytosol; glutamatergic synapse; multivesicular body; neuromuscular junction; nucleotide-activated protein kinase complex; plasma membrane raft; sperm connecting piece; synapse | cAMP binding cAMP-dependent protein kinase inhibitor activity cAMP-dependent protein kinase regulator activity protein domain specific binding protein kinase A catalytic subunit binding ubiquitin protein ligase binding | Rattus norvegicus | Acetylation cAMP cAMP-binding Cell membrane Disulfide bond Membrane Nucleotide-binding Phosphoprotein Reference proteome Repeat | MASGSMAASE | MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEARQIQSLQKSGIRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGP... | adenylate cyclase-activating G protein-coupled receptor signaling pathway cardiac muscle cell proliferation cellular response to glucagon stimulus female meiotic nuclear division heart development mesoderm formation negative regulation of activated T cell proliferation negative regulation of gene expression negative re... |
apoptotic process negative regulation of sperm capacitation positive regulation of granulocyte macrophage colony-stimulating factor production regulation of binding of sperm to zona pellucida | extracellular region | small molecule binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Reference proteome Secreted Signal | MLCLLLTLGV | MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF | apoptotic process negative regulation of sperm capacitation positive regulation of granulocyte macrophage colony-stimulating factor production regulation of binding of sperm to zona pellucida extracellular region small molecule binding Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disulfide b... |
cellular hyperosmotic salinity response cellular hypotonic salinity response cellular response to cAMP cellular response to insulin stimulus cellular response to magnesium ion cellular response to phorbol 13-acetate 12-myristate cellular response to raffinose cellular response to xenobiotic stimulus dephosphorylation f... | cytoplasm; cytosol; extracellular exosome; nucleus | AMP binding fructose 1,6-bisphosphate 1-phosphatase activity identical protein binding metal ion binding monosaccharide binding RNA polymerase II-specific DNA-binding transcription factor binding | Homo sapiens | 3D-structure Acetylation Allosteric enzyme Carbohydrate metabolism Direct protein sequencing Disease variant Gluconeogenesis Hydrolase Magnesium Metal-binding Phosphoprotein Reference proteome | MADQAPFDTD | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILG... | cellular hyperosmotic salinity response cellular hypotonic salinity response cellular response to cAMP cellular response to insulin stimulus cellular response to magnesium ion cellular response to phorbol 13-acetate 12-myristate cellular response to raffinose cellular response to xenobiotic stimulus dephosphorylation f... |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway dopamine receptor signaling pathway muscle contraction | heterotrimeric G-protein complex; plasma membrane | corticotropin-releasing hormone receptor 1 binding G protein-coupled serotonin receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity metal ion binding mu-type opioid receptor binding | Homo sapiens | 3D-structure ADP-ribosylation Alternative splicing Cell membrane Disease variant Epilepsy GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Palmitate Reference proteome Transducer | MGCTLSAEER | MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIY... | adenylate cyclase-modulating G protein-coupled receptor signaling pathway dopamine receptor signaling pathway muscle contraction heterotrimeric G-protein complex; plasma membrane corticotropin-releasing hormone receptor 1 binding G protein-coupled serotonin receptor binding G-protein beta/gamma-subunit complex binding ... |
monoatomic cation transmembrane transport response to insecticide synaptic transmission, cholinergic | acetylcholine-gated channel complex; neuron projection; postsynaptic membrane; synapse | acetylcholine-gated monoatomic cation-selective channel activity excitatory extracellular ligand-gated monoatomic ion channel activity transmembrane signaling receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | Drosophila melanogaster | Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MGSVLFAAVF | MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV... | monoatomic cation transmembrane transport response to insecticide synaptic transmission, cholinergic acetylcholine-gated channel complex; neuron projection; postsynaptic membrane; synapse acetylcholine-gated monoatomic cation-selective channel activity excitatory extracellular ligand-gated monoatomic ion channel activi... |
behavioral response to nicotine nervous system development response to nicotine synaptic transmission involved in micturition synaptic transmission, cholinergic | acetylcholine-gated channel complex; endoplasmic reticulum; Golgi apparatus; neuron projection; nuclear speck; postsynaptic membrane; synapse | acetylcholine receptor activity acetylcholine-gated monoatomic cation-selective channel activity | Gallus gallus | Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Golgi apparatus Ion channel Ion transport Ligand-gated ion channel Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MQSIHALLLT | MQSIHALLLTAAVCILFQGCGGSEPEHRLYAALFKNYNQFVRPVKNASDPVIIQFEVSMSQLVKVDEVNQIMETNLWLKHIWNDYKLRWNPVDYGGAEFIRVPSGQIWKPDIVLYNNAVGDFQVDDKTKALLKYTGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSTMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYTDITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH... | behavioral response to nicotine nervous system development response to nicotine synaptic transmission involved in micturition synaptic transmission, cholinergic acetylcholine-gated channel complex; endoplasmic reticulum; Golgi apparatus; neuron projection; nuclear speck; postsynaptic membrane; synapse acetylcholine rec... |
response to nicotine synaptic transmission, cholinergic | neuron projection; postsynaptic membrane; synapse | acetylcholine-gated monoatomic cation-selective channel activity transmembrane signaling receptor activity | Gallus gallus | Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Lipoprotein Membrane Palmitate Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MGFLVSKGNL | MGFLVSKGNLLLLLCASIFPAFGHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPQEYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRIKWMPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLVSMHSHVDQLDYWESGEWVIINAVGNYNSKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITV... | response to nicotine synaptic transmission, cholinergic neuron projection; postsynaptic membrane; synapse acetylcholine-gated monoatomic cation-selective channel activity transmembrane signaling receptor activity Gallus gallus Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel ... |
acetylcholine receptor signaling pathway B cell activation behavioral response to nicotine calcium ion transport cognition DNA repair exploration behavior inhibitory postsynaptic potential locomotory behavior membrane depolarization nervous system process neuronal action potential presynaptic modulation of chemical syn... | acetylcholine-gated channel complex; cholinergic synapse; dendrite; dopaminergic synapse; external side of plasma membrane; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic specialization membrane; presynaptic membrane; protein-containing complex; synapse | acetylcholine binding acetylcholine receptor activity acetylcholine-gated monoatomic cation-selective channel activity heterocyclic compound binding monoatomic ion channel activity protein-containing complex binding quaternary ammonium group binding transmitter-gated monoatomic ion channel activity involved in regulati... | Rattus norvegicus | Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Lipoprotein Membrane Palmitate Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MANSGTGAPP | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFV... | acetylcholine receptor signaling pathway B cell activation behavioral response to nicotine calcium ion transport cognition DNA repair exploration behavior inhibitory postsynaptic potential locomotory behavior membrane depolarization nervous system process neuronal action potential presynaptic modulation of chemical syn... |
behavioral response to nicotine memory response to hypoxia visual learning | acetylcholine-gated channel complex; axon; cytoplasm; dendrite; neuron projection; perikaryon; postsynaptic membrane; synapse | acetylcholine binding acetylcholine receptor activity acetylcholine-gated monoatomic cation-selective channel activity | Gallus gallus | Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MALLRVLCLL | MALLRVLCLLAALRRSLCTDTEERLVEYLLDPTRYNKLIRPATNGSQLVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVISYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT... | behavioral response to nicotine memory response to hypoxia visual learning acetylcholine-gated channel complex; axon; cytoplasm; dendrite; neuron projection; perikaryon; postsynaptic membrane; synapse acetylcholine binding acetylcholine receptor activity acetylcholine-gated monoatomic cation-selective channel activity ... |
anatomical structure development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration regulation of cell morphogenesis | basement membrane; cell surface; collagen-containing extracellular matrix; cytoplasm; endocytic vesicle lumen; extracellular region; extracellular space; intracellular membrane-bounded organelle; nuclear matrix; plasma membrane; platelet alpha granule; platelet alpha granule lumen; platelet alpha granule membrane | calcium ion binding collagen binding extracellular matrix binding | Homo sapiens | 3D-structure Basement membrane Calcium Copper Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Metal-binding Osteogenesis imperfecta Reference proteome Secreted Signal | MRAWIFFLLC | MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI | anatomical structure development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration regulation of cell morphogenesis basement membrane; cell surface; collagen-containing extracellular matrix; cytoplasm; endocytic vesicle lumen; ext... |
biomineral tissue development bone mineralization calcium ion homeostasis cellular homeostasis cellular response to organic cyclic compound dephosphorylation developmental process involved in reproduction endochondral ossification futile creatine cycle inhibition of non-skeletal tissue mineralization phosphate ion home... | extracellular matrix; extracellular membrane-bounded organelle; mitochondrial intermembrane space; mitochondrial membrane; plasma membrane; side of membrane | ADP phosphatase activity alkaline phosphatase activity ATP hydrolysis activity calcium ion binding inorganic diphosphate phosphatase activity phosphoamidase activity phosphoethanolamine phosphatase activity pyridoxal phosphatase activity pyrophosphatase activity | Bos taurus | Biomineralization Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Magnesium Membrane Metal-binding Mitochondrion Phosphoprotein Reference proteome Signal Zinc | MISPFLLLAI | MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRIL... | biomineral tissue development bone mineralization calcium ion homeostasis cellular homeostasis cellular response to organic cyclic compound dephosphorylation developmental process involved in reproduction endochondral ossification futile creatine cycle inhibition of non-skeletal tissue mineralization phosphate ion home... |
cellular detoxification of nitrogen compound glutathione derivative biosynthetic process glutathione metabolic process hepoxilin biosynthetic process nitrobenzene metabolic process prostaglandin metabolic process xenobiotic catabolic process | cytoplasm; cytosol; intercellular bridge | enzyme binding glutathione binding glutathione transferase activity protein homodimerization activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Lipid metabolism Phosphoprotein Reference proteome Transferase | MPMILGYWDI | MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK | cellular detoxification of nitrogen compound glutathione derivative biosynthetic process glutathione metabolic process hepoxilin biosynthetic process nitrobenzene metabolic process prostaglandin metabolic process xenobiotic catabolic process cytoplasm; cytosol; intercellular bridge enzyme binding glutathione binding gl... |
actin filament organization cardiac muscle contraction cellular response to reactive oxygen species cytoskeleton organization muscle filament sliding negative regulation of cell migration negative regulation of vascular associated smooth muscle cell migration negative regulation of vascular associated smooth muscle cel... | actin cytoskeleton; actin filament; bleb; cytoskeleton; cytosol; muscle thin filament tropomyosin; ruffle membrane; sarcomere; stress fiber | actin binding actin filament binding cytoskeletal protein binding identical protein binding protein heterodimerization activity protein homodimerization activity structural constituent of cytoskeleton structural constituent of muscle | Homo sapiens | 3D-structure Acetylation Actin-binding Alternative splicing Cardiomyopathy Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Muscle protein Phosphoprotein Reference proteome | MDAIKKKMQM | MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI | actin filament organization cardiac muscle contraction cellular response to reactive oxygen species cytoskeleton organization muscle filament sliding negative regulation of cell migration negative regulation of vascular associated smooth muscle cell migration negative regulation of vascular associated smooth muscle cel... |
actin filament organization muscle contraction | actin cytoskeleton; actin filament; cortical cytoskeleton; cytoplasm; podosome; stress fiber | actin filament binding identical protein binding metal ion binding protein heterodimerization activity protein homodimerization activity | Rattus norvegicus | Acetylation Actin-binding Calcium Coiled coil Cytoplasm Cytoskeleton Metal-binding Muscle protein Phosphoprotein Reference proteome | MAGLNSLEAV | MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREKAEGDAAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKSSDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI | actin filament organization muscle contraction actin cytoskeleton; actin filament; cortical cytoskeleton; cytoplasm; podosome; stress fiber actin filament binding identical protein binding metal ion binding protein heterodimerization activity protein homodimerization activity Rattus norvegicus Acetylation Actin-binding... |
cell cycle cell division clathrin coat assembly clathrin-dependent endocytosis intracellular protein transport | clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin complex; clathrin vesicle coat; clathrin-coated endocytic vesicle; cytoplasmic vesicle; cytosol; endolysosome membrane; membrane; plasma membrane; postsynaptic endocytic zone cytoplasmic component; presynaptic endocytic z... | clathrin heavy chain binding GTPase binding peptide binding protein-containing complex binding structural molecule activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Calcium Cell cycle Cell division Coated pit Cytoplasm Cytoplasmic vesicle Cytoskeleton Membrane Mitosis Phosphoprotein Reference proteome | MAELDPFGAP | MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH | cell cycle cell division clathrin coat assembly clathrin-dependent endocytosis intracellular protein transport clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin complex; clathrin vesicle coat; clathrin-coated endocytic vesicle; cytoplasmic vesicle; cytosol; endolysosome ... |
clathrin-dependent endocytosis intracellular protein transport | ciliary membrane; clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin vesicle coat; clathrin-coated endocytic vesicle; cytosol; intracellular membrane-bounded organelle; plasma membrane; postsynaptic endocytic zone cytoplasmic component; presynaptic endocytic zone membrane... | clathrin heavy chain binding peptide binding structural molecule activity | Homo sapiens | Acetylation Alternative splicing Calcium Coated pit Cytoplasmic vesicle Disulfide bond Membrane Phosphoprotein Reference proteome | MADDFGFFSS | MADDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDEGFGAPAGSHAAPAQPGPTSGAGSEDMGTTVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQELDAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIGYVASEEAFVKESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPLSR | clathrin-dependent endocytosis intracellular protein transport ciliary membrane; clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin vesicle coat; clathrin-coated endocytic vesicle; cytosol; intracellular membrane-bounded organelle; plasma membrane; postsynaptic endocytic ... |
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