Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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acetyl-CoA biosynthetic process from pyruvate glucose metabolic process tricarboxylic acid cycle | mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; nucleus; pyruvate dehydrogenase complex | pyruvate dehydrogenase (acetyl-transferring) activity pyruvate dehydrogenase (NAD+) activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Carbohydrate metabolism Direct protein sequencing Disease variant Glucose metabolism Leigh syndrome Mitochondrion Oxidoreductase Phosphoprotein Primary mitochondrial disease Pyruvate Reference proteome Thiamine pyrophosphate Transit peptide Tricarboxylic acid cycle | MRKMLAAVSR | MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS | acetyl-CoA biosynthetic process from pyruvate glucose metabolic process tricarboxylic acid cycle mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; nucleus; pyruvate dehydrogenase complex pyruvate dehydrogenase (acetyl-transferring) activity pyruvate dehydrogenase (NAD+) activity Homo sapiens 3D-structure Acetylation Alternative splicing Carbohydrate metabolism Direct protein sequencing Disease variant Glucose metabolism Leigh syndrome Mitochondrion Oxidoreductase Phosphoprotein Primary mitochondrial disease Pyruvate Reference proteome Thiamine pyrophosphate Transit peptide Tricarboxylic acid cycle MRKMLAAVSR MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS |
actin cytoskeleton organization cell projection organization cortical actin cytoskeleton organization hematopoietic progenitor cell differentiation integrin-mediated signaling pathway negative regulation of calcium-mediated signaling negative regulation of G protein-coupled receptor signaling pathway negative regulation of inositol phosphate biosynthetic process phosphatidylinositol metabolic process phospholipase C-inhibiting G protein-coupled receptor signaling pathway platelet aggregation platelet degranulation positive regulation of actin filament bundle assembly positive regulation of actin filament depolymerization positive regulation of inositol-polyphosphate 5-phosphatase activity positive regulation of integrin activation positive regulation of platelet activation protein kinase C signaling protein secretion by platelet regulation of cell diameter ruffle organization thrombin-activated receptor signaling pathway vesicle docking involved in exocytosis | cytoplasm; cytosol; extracellular region; membrane; plasma membrane; ruffle membrane | phosphatidylinositol-3,4-bisphosphate binding protein homodimerization activity protein kinase C binding | Homo sapiens | 3D-structure Acetylation Phosphoprotein Reference proteome Repeat | MEPKRIREGY | MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK | actin cytoskeleton organization cell projection organization cortical actin cytoskeleton organization hematopoietic progenitor cell differentiation integrin-mediated signaling pathway negative regulation of calcium-mediated signaling negative regulation of G protein-coupled receptor signaling pathway negative regulation of inositol phosphate biosynthetic process phosphatidylinositol metabolic process phospholipase C-inhibiting G protein-coupled receptor signaling pathway platelet aggregation platelet degranulation positive regulation of actin filament bundle assembly positive regulation of actin filament depolymerization positive regulation of inositol-polyphosphate 5-phosphatase activity positive regulation of integrin activation positive regulation of platelet activation protein kinase C signaling protein secretion by platelet regulation of cell diameter ruffle organization thrombin-activated receptor signaling pathway vesicle docking involved in exocytosis cytoplasm; cytosol; extracellular region; membrane; plasma membrane; ruffle membrane phosphatidylinositol-3,4-bisphosphate binding protein homodimerization activity protein kinase C binding Homo sapiens 3D-structure Acetylation Phosphoprotein Reference proteome Repeat MEPKRIREGY MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK |
cytoplasmic translation translational elongation | cytosolic large ribosomal subunit; cytosolic ribosome | protein kinase activator activity ribonucleoprotein complex binding structural constituent of ribosome | Drosophila melanogaster | Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein | MSTKAELACV | MSTKAELACVYASLILVDDDVAVTGEKINTILKAANVEVEPYWPGLFAKALEGINVKDLITNIGSGVGAAPAGGAAPAAAAAAPAAESKKEEKKKEEESDQSDDDMGFGLFD | cytoplasmic translation translational elongation cytosolic large ribosomal subunit; cytosolic ribosome protein kinase activator activity ribonucleoprotein complex binding structural constituent of ribosome Drosophila melanogaster Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein MSTKAELACV MSTKAELACVYASLILVDDDVAVTGEKINTILKAANVEVEPYWPGLFAKALEGINVKDLITNIGSGVGAAPAGGAAPAAAAAAPAAESKKEEKKKEEESDQSDDDMGFGLFD |
cellular respiration mitochondrial electron transport, ubiquinol to cytochrome c response to glucagon | membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrion; nucleus | heme binding metal ion binding ubiquinol-cytochrome-c reductase activity | Homo sapiens | 3D-structure Disease variant Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Phosphoprotein Primary mitochondrial disease Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport | MAAAAASLRG | MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK | cellular respiration mitochondrial electron transport, ubiquinol to cytochrome c response to glucagon membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrion; nucleus heme binding metal ion binding ubiquinol-cytochrome-c reductase activity Homo sapiens 3D-structure Disease variant Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Phosphoprotein Primary mitochondrial disease Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport MAAAAASLRG MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK |
mRNA splicing, via spliceosome U2-type prespliceosome assembly | catalytic step 2 spliceosome; cytoplasmic ribonucleoprotein granule; fibrillar center; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2 snRNP; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U2-type spliceosomal complex | snRNP binding U1 snRNA binding | Homo sapiens | 3D-structure Acetylation Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation | MDIRPNHTIY | MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK | mRNA splicing, via spliceosome U2-type prespliceosome assembly catalytic step 2 spliceosome; cytoplasmic ribonucleoprotein granule; fibrillar center; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2 snRNP; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U2-type spliceosomal complex snRNP binding U1 snRNA binding Homo sapiens 3D-structure Acetylation Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation MDIRPNHTIY MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK |
iron ion transport negative regulation of substrate adhesion-dependent cell spreading positive regulation of extracellular matrix disassembly positive regulation of plasminogen activation | cell surface; early endosome; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane; recycling endosome; side of membrane | iron ion binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Ion transport Iron Iron transport Lipoprotein Membrane Metal-binding Phosphoprotein Reference proteome Repeat Signal Transport Zinc | MRGPSGALWL | MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL | iron ion transport negative regulation of substrate adhesion-dependent cell spreading positive regulation of extracellular matrix disassembly positive regulation of plasminogen activation cell surface; early endosome; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane; recycling endosome; side of membrane iron ion binding Homo sapiens 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Ion transport Iron Iron transport Lipoprotein Membrane Metal-binding Phosphoprotein Reference proteome Repeat Signal Transport Zinc MRGPSGALWL MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL |
cellular response to dopamine cellular response to serotonin peptide cross-linking phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of small GTPase mediated signal transduction protein deamination protein homooligomerization proteolysis regulation of apoptotic cell clearance regulation of apoptotic process regulation of hemostasis | chromatin; cytosol; extracellular region; mitochondrion; nucleus; plasma membrane | calcium ion binding GTP binding histone dopaminyltransferase activity histone serotonyltransferase activity peptidase activity peptide dopaminyltransferase activity peptide histaminyltransferase activity peptide noradrenalinyltransferase activity peptide serotonyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine glutaminase activity transaminase activity | Cavia cutleri | Acetylation Acyltransferase Calcium Cell membrane Chromosome Cytoplasm Direct protein sequencing Disulfide bond Extracellular matrix GTP-binding Hydrolase Isopeptide bond Membrane Metal-binding Mitochondrion Nucleotide-binding Nucleus Protease S-nitrosylation Secreted Transferase | MAEDLILERC | MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA | cellular response to dopamine cellular response to serotonin peptide cross-linking phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of small GTPase mediated signal transduction protein deamination protein homooligomerization proteolysis regulation of apoptotic cell clearance regulation of apoptotic process regulation of hemostasis chromatin; cytosol; extracellular region; mitochondrion; nucleus; plasma membrane calcium ion binding GTP binding histone dopaminyltransferase activity histone serotonyltransferase activity peptidase activity peptide dopaminyltransferase activity peptide histaminyltransferase activity peptide noradrenalinyltransferase activity peptide serotonyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine glutaminase activity transaminase activity Cavia cutleri Acetylation Acyltransferase Calcium Cell membrane Chromosome Cytoplasm Direct protein sequencing Disulfide bond Extracellular matrix GTP-binding Hydrolase Isopeptide bond Membrane Metal-binding Mitochondrion Nucleotide-binding Nucleus Protease S-nitrosylation Secreted Transferase MAEDLILERC MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA |
adenylate cyclase-activating adrenergic receptor signaling pathway brown fat cell differentiation diet induced thermogenesis fear response heat generation negative regulation of multicellular organism growth norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure positive regulation of cold-induced thermogenesis positive regulation of GTPase activity positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine regulation of circadian sleep/wake cycle, sleep response to cold | early endosome; neuronal dense core vesicle; plasma membrane; Schaffer collateral - CA1 synapse | alpha-2A adrenergic receptor binding beta-adrenergic receptor activity beta1-adrenergic receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential PDZ domain binding protein heterodimerization activity | Homo sapiens | 3D-structure Cell membrane Disulfide bond Endosome G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Phosphoprotein Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MGAGVLVLGA | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV | adenylate cyclase-activating adrenergic receptor signaling pathway brown fat cell differentiation diet induced thermogenesis fear response heat generation negative regulation of multicellular organism growth norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure positive regulation of cold-induced thermogenesis positive regulation of GTPase activity positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine regulation of circadian sleep/wake cycle, sleep response to cold early endosome; neuronal dense core vesicle; plasma membrane; Schaffer collateral - CA1 synapse alpha-2A adrenergic receptor binding beta-adrenergic receptor activity beta1-adrenergic receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential PDZ domain binding protein heterodimerization activity Homo sapiens 3D-structure Cell membrane Disulfide bond Endosome G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Phosphoprotein Receptor Reference proteome Transducer Transmembrane Transmembrane helix MGAGVLVLGA MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV |
cardiac muscle contraction positive regulation of ATP-dependent activity regulation of striated muscle contraction regulation of the force of heart contraction ventricular cardiac muscle tissue morphogenesis | A band; cytosol; I band; muscle myosin complex; myosin II complex; sarcomere | actin monomer binding calcium ion binding myosin II heavy chain binding structural constituent of muscle | Homo sapiens | 3D-structure Cardiomyopathy Direct protein sequencing Disease variant Methylation Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat | MAPKKPEPKK | MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFMLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMSS | cardiac muscle contraction positive regulation of ATP-dependent activity regulation of striated muscle contraction regulation of the force of heart contraction ventricular cardiac muscle tissue morphogenesis A band; cytosol; I band; muscle myosin complex; myosin II complex; sarcomere actin monomer binding calcium ion binding myosin II heavy chain binding structural constituent of muscle Homo sapiens 3D-structure Cardiomyopathy Direct protein sequencing Disease variant Methylation Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat MAPKKPEPKK MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFMLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMSS |
proteolysis | extracellular region | serine-type endopeptidase activity | Thermus aquaticus | 3D-structure Autocatalytic cleavage Direct protein sequencing Disulfide bond Hydrolase Protease Secreted Serine protease Signal Zymogen | MRKTYWLMAL | MRKTYWLMALFAVLVLGGCQMASRSDPTPTLAEAFWPKEAPVYGLDDPEAIPGRYIVVFKKGKGQSLLQGGITTLQARLAPQGVVVTQAYTGALQGFAAEMAPQALEAFRQSPDVEFIEADKVVRAWATQSPAPWGLDRIDQRDLPLSNSYTYTATGRGVNVYVIDTGIRTTHREFGGRARVGYDALGGNGQDCNGHGTHVAGTIGGVTYGVAKAVNLYAVRVLDCNGSGSTSGVIAGVDWVTRNHRRPAVANMSLGGGVSTALDNAVKNSIAAGVVYAVAAGNDNANACNYSPARVAEALTVGATTSSDARASFSNYGSCVDLFAPGASIPSAWYTSDTATQTLNGTSMATPHVAGVAALYLEQNPSATPASVASAILNGATTGRLSGIGSGSPNRLLYSLLSSGSGSTAPCTSCSYYTGSLSGPGDYNFQPNGTYYYSPAGTHRAWLRGPAGTDFDLYLWRWDGSRWLTVGSSTGPTSEESLSYSGTAGYYLWRIYAYSGSGMYEFWLQRP | proteolysis extracellular region serine-type endopeptidase activity Thermus aquaticus3D-structure Autocatalytic cleavage Direct protein sequencing Disulfide bond Hydrolase Protease Secreted Serine protease Signal Zymogen MRKTYWLMAL MRKTYWLMALFAVLVLGGCQMASRSDPTPTLAEAFWPKEAPVYGLDDPEAIPGRYIVVFKKGKGQSLLQGGITTLQARLAPQGVVVTQAYTGALQGFAAEMAPQALEAFRQSPDVEFIEADKVVRAWATQSPAPWGLDRIDQRDLPLSNSYTYTATGRGVNVYVIDTGIRTTHREFGGRARVGYDALGGNGQDCNGHGTHVAGTIGGVTYGVAKAVNLYAVRVLDCNGSGSTSGVIAGVDWVTRNHRRPAVANMSLGGGVSTALDNAVKNSIAAGVVYAVAAGNDNANACNYSPARVAEALTVGATTSSDARASFSNYGSCVDLFAPGASIPSAWYTSDTATQTLNGTSMATPHVAGVAALYLEQNPSATPASVASAILNGATTGRLSGIGSGSPNRLLYSLLSSGSGSTAPCTSCSYYTGSLSGPGDYNFQPNGTYYYSPAGTHRAWLRGPAGTDFDLYLWRWDGSRWLTVGSSTGPTSEESLSYSGTAGYYLWRIYAYSGSGMYEFWLQRP |
animal organ morphogenesis apoptotic process involved in morphogenesis cartilage condensation cell differentiation cell-cell signaling cellular response to leukemia inhibitory factor chondroblast differentiation cranial suture morphogenesis embryonic hindlimb morphogenesis epithelial cell apoptotic process fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation negative regulation of apoptotic process odontogenesis of dentin-containing tooth positive regulation of cell division positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of gene expression positive regulation of protein phosphorylation positive regulation of stem cell proliferation positive regulation of transcription by RNA polymerase II regulation of cell migration regulation of endothelial cell chemotaxis to fibroblast growth factor signal transduction somatic stem cell population maintenance stem cell proliferation | cytoplasm; extracellular region; extracellular space | fibroblast growth factor receptor binding growth factor activity heparin binding | Homo sapiens | 3D-structure Alternative splicing Developmental protein Differentiation Growth factor Heparin-binding Mitogen Proto-oncogene Reference proteome Secreted Signal | MSGPGTAAVA | MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL | animal organ morphogenesis apoptotic process involved in morphogenesis cartilage condensation cell differentiation cell-cell signaling cellular response to leukemia inhibitory factor chondroblast differentiation cranial suture morphogenesis embryonic hindlimb morphogenesis epithelial cell apoptotic process fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation negative regulation of apoptotic process odontogenesis of dentin-containing tooth positive regulation of cell division positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of gene expression positive regulation of protein phosphorylation positive regulation of stem cell proliferation positive regulation of transcription by RNA polymerase II regulation of cell migration regulation of endothelial cell chemotaxis to fibroblast growth factor signal transduction somatic stem cell population maintenance stem cell proliferation cytoplasm; extracellular region; extracellular space fibroblast growth factor receptor binding growth factor activity heparin binding Homo sapiens 3D-structure Alternative splicing Developmental protein Differentiation Growth factor Heparin-binding Mitogen Proto-oncogene Reference proteome Secreted Signal MSGPGTAAVA MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL |
mRNA splicing, via spliceosome negative regulation of chaperone-mediated autophagy negative regulation of protein refolding positive regulation of mRNA splicing, via spliceosome regulation of ATP-dependent activity regulation of RNA splicing | nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2-type prespliceosome | mRNA binding RNA binding U1 snRNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Direct protein sequencing Isopeptide bond mRNA processing Nucleus Phosphoprotein Reference proteome Ribonucleoprotein RNA-binding Ubl conjugation | MTQFLPPNLL | MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE | mRNA splicing, via spliceosome negative regulation of chaperone-mediated autophagy negative regulation of protein refolding positive regulation of mRNA splicing, via spliceosome regulation of ATP-dependent activity regulation of RNA splicing nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U2-type prespliceosome mRNA binding RNA binding U1 snRNA binding Homo sapiens 3D-structure Acetylation Alternative splicing Direct protein sequencing Isopeptide bond mRNA processing Nucleus Phosphoprotein Reference proteome Ribonucleoprotein RNA-binding Ubl conjugation MTQFLPPNLL MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE |
chaperone cofactor-dependent protein refolding DNA replication protein folding protein refolding protein unfolding protein-containing complex assembly response to heat viral process | cytoplasm; cytosol; membrane; protein-containing complex | ATP binding heat shock protein binding protein disulfide isomerase activity protein homodimerization activity protein-disulfide reductase activity protein-folding chaperone binding sigma factor antagonist activity unfolded protein binding zinc ion binding | Escherichia coli | 3D-structure Chaperone Cytoplasm Direct protein sequencing DNA replication Metal-binding Reference proteome Repeat Stress response Zinc Zinc-finger | MAKQDYYEIL | MAKQDYYEILGVSKTAEEREIRKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNERQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR | chaperone cofactor-dependent protein refolding DNA replication protein folding protein refolding protein unfolding protein-containing complex assembly response to heat viral process cytoplasm; cytosol; membrane; protein-containing complex ATP binding heat shock protein binding protein disulfide isomerase activity protein homodimerization activity protein-disulfide reductase activity protein-folding chaperone binding sigma factor antagonist activity unfolded protein binding zinc ion binding Escherichia coli 3D-structure Chaperone Cytoplasm Direct protein sequencing DNA replication Metal-binding Reference proteome Repeat Stress response Zinc Zinc-finger MAKQDYYEIL MAKQDYYEILGVSKTAEEREIRKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNERQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR |
actin cytoskeleton organization cellularization courtship behavior determination of adult lifespan DNA endoreduplication dorsal closure female germline ring canal formation head involution imaginal disc-derived male genitalia development JNK cascade oocyte karyosome formation oogenesis open tracheal system development ovarian fusome organization ovarian nurse cell to oocyte transport peptidyl-tyrosine phosphorylation regulation of actin filament polymerization salivary gland morphogenesis sensitization spiracle morphogenesis, open tracheal system | apical part of cell; cell periphery; cytoplasm; germline ring canal; plasma membrane | ATP binding metal ion binding non-membrane spanning protein tyrosine kinase activity protein tyrosine kinase activity | Drosophila melanogaster | Alternative splicing ATP-binding Kinase Metal-binding Nucleotide-binding Phosphoprotein Proto-oncogene Reference proteome SH2 domain SH3 domain Transferase Tyrosine-protein kinase Zinc Zinc-finger | MMGTKHRNSH | MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD | actin cytoskeleton organization cellularization courtship behavior determination of adult lifespan DNA endoreduplication dorsal closure female germline ring canal formation head involution imaginal disc-derived male genitalia development JNK cascade oocyte karyosome formation oogenesis open tracheal system development ovarian fusome organization ovarian nurse cell to oocyte transport peptidyl-tyrosine phosphorylation regulation of actin filament polymerization salivary gland morphogenesis sensitization spiracle morphogenesis, open tracheal system apical part of cell; cell periphery; cytoplasm; germline ring canal; plasma membrane ATP binding metal ion binding non-membrane spanning protein tyrosine kinase activity protein tyrosine kinase activity Drosophila melanogaster Alternative splicing ATP-binding Kinase Metal-binding Nucleotide-binding Phosphoprotein Proto-oncogene Reference proteome SH2 domain SH3 domain Transferase Tyrosine-protein kinase Zinc Zinc-finger MMGTKHRNSH MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD |
lipid biosynthetic process medium-chain fatty acid biosynthetic process | cytosol | acyl- hydrolase activity dodecanoyl- hydrolase activity myristoyl- hydrolase activity myristoyl-CoA hydrolase activity oleoyl- hydrolase activity palmitoyl- hydrolase activity palmitoyl-CoA hydrolase activity | Rattus norvegicus | Acetylation Cytoplasm Direct protein sequencing Fatty acid biosynthesis Fatty acid metabolism Hydrolase Lipid biosynthesis Lipid metabolism Reference proteome | METAVNAKSP | METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT | lipid biosynthetic process medium-chain fatty acid biosynthetic process cytosol acyl- hydrolase activity dodecanoyl- hydrolase activity myristoyl- hydrolase activity myristoyl-CoA hydrolase activity oleoyl- hydrolase activity palmitoyl- hydrolase activity palmitoyl-CoA hydrolase activity Rattus norvegicus Acetylation Cytoplasm Direct protein sequencing Fatty acid biosynthesis Fatty acid metabolism Hydrolase Lipid biosynthesis Lipid metabolism Reference proteome METAVNAKSP METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT |
antibody-dependent cellular cytotoxicity calcium-mediated signaling cell surface receptor signaling pathway Fc-gamma receptor signaling pathway immune response macrophage activation natural killer cell activation natural killer cell degranulation natural killer cell mediated cytotoxicity phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of natural killer cell proliferation positive regulation of tumor necrosis factor production regulation of immune response | external side of plasma membrane; extracellular exosome; extracellular space; Fc-gamma receptor III complex; plasma membrane | IgG binding immune receptor activity low-affinity IgG receptor activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Cell membrane Disulfide bond Glycoprotein IgG-binding protein Immunity Immunoglobulin domain Membrane Phosphoprotein Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix | MWQLLLPTAL | MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK | antibody-dependent cellular cytotoxicity calcium-mediated signaling cell surface receptor signaling pathway Fc-gamma receptor signaling pathway immune response macrophage activation natural killer cell activation natural killer cell degranulation natural killer cell mediated cytotoxicity phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of natural killer cell proliferation positive regulation of tumor necrosis factor production regulation of immune response external side of plasma membrane; extracellular exosome; extracellular space; Fc-gamma receptor III complex; plasma membrane IgG binding immune receptor activity low-affinity IgG receptor activity transmembrane signaling receptor activity Homo sapiens 3D-structure Cell membrane Disulfide bond Glycoprotein IgG-binding protein Immunity Immunoglobulin domain Membrane Phosphoprotein Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix MWQLLLPTAL MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK |
leucine biosynthetic process negative regulation of transcription by RNA polymerase II positive regulation of leucine biosynthetic process positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription | nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding transcription cis-regulatory region binding zinc ion binding | Saccharomyces cerevisiae | 3D-structure Activator Amino-acid biosynthesis Branched-chain amino acid biosynthesis DNA-binding Leucine biosynthesis Metal-binding Nucleus Reference proteome Transcription Transcription regulation Zinc | MEGRSDFVAT | MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV | leucine biosynthetic process negative regulation of transcription by RNA polymerase II positive regulation of leucine biosynthetic process positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding transcription cis-regulatory region binding zinc ion binding Saccharomyces cerevisiae 3D-structure Activator Amino-acid biosynthesis Branched-chain amino acid biosynthesis DNA-binding Leucine biosynthesis Metal-binding Nucleus Reference proteome Transcription Transcription regulation Zinc MEGRSDFVAT MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV |
adherens junction organization calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell morphogenesis cell-cell adhesion mediated by cadherin cell-cell junction assembly homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly | adherens junction; apical junction complex; catenin complex; cell-cell junction; flotillin complex | cadherin binding calcium ion binding | Gallus gallus | Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Membrane Metal-binding Reference proteome Repeat Signal Transmembrane Transmembrane helix | MGRRWGSPAL | MGRRWGSPALQRFPVLVLLLLLQVCGRRCDEAAPCQPGFAAETFSFSVPQDSVAAGRELGRVSFAACSGRPWAVYVPTDTRFKVNGDGVVSTKRPLTLYGRKISFTIYAQDAMGKRHSARVTVGRHRHRRHHHNHHLQDTTPAVLTFPKHDPGFLRRQKRDWVIPPISCLENHRGPYPMRLVQIKSNKDKESKVYYSITGQGADSPPVGIFIIERETGWLEVTEQLDREKIDRYTLLSHAVSASGQPVEDPMEIIITVMDQNDNKPVFIKEVFVGYIEENAKPGTSVMTVNATDADDAVNTDNGIVSYSIVSQQPPRPHPQMFTIDPAKGIISVLGTGLDRETTPNYTLIVQATDQEGKGLSNTATAIIEVTDANDNIPIFNPTMYEGVVEENKPGTEVARLTVTDQDAPGSPAWQAVYHIKSGNLDGAFSIITDPSTNNGILKTAKGLDYETKSRYDLVVTVENKVPLSVPITLSTASVLVTVLDVNEPPVFVPPIKRVGVPEDLPVGQQVTSYTAQDPDRDMRQKITYRMGSDPAGWLYIHPENGIVTATQPLDRESVHAINSTYKAIILAVDNGIPDTTGTGTLLLLLQDVNDNGPTPEPRSFEICSRQPEKQILSIVDKDLPPHTYPFKAALEHGSSNNWTVEIRGQDELAMGLKKELEPGEYNIFVKLTDSQGKAQVTQVKAQVCECEGTAKNCERRSYIVGGLGVPAILGILGGILALLILLLLLLLFARRRKVEKEPLLPPEDDMRDNVYNYDEEGGGEEDQDYDLSQLHRGLDARPEVIRNDVAPPLMAAPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGGGSEATSLSSLNSSASDQDQDYDYLNEWGNRFKKLAELYGGGEDDE | adherens junction organization calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell morphogenesis cell-cell adhesion mediated by cadherin cell-cell junction assembly homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly adherens junction; apical junction complex; catenin complex; cell-cell junction; flotillin complex cadherin binding calcium ion binding Gallus gallus Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Membrane Metal-binding Reference proteome Repeat Signal Transmembrane Transmembrane helix MGRRWGSPAL MGRRWGSPALQRFPVLVLLLLLQVCGRRCDEAAPCQPGFAAETFSFSVPQDSVAAGRELGRVSFAACSGRPWAVYVPTDTRFKVNGDGVVSTKRPLTLYGRKISFTIYAQDAMGKRHSARVTVGRHRHRRHHHNHHLQDTTPAVLTFPKHDPGFLRRQKRDWVIPPISCLENHRGPYPMRLVQIKSNKDKESKVYYSITGQGADSPPVGIFIIERETGWLEVTEQLDREKIDRYTLLSHAVSASGQPVEDPMEIIITVMDQNDNKPVFIKEVFVGYIEENAKPGTSVMTVNATDADDAVNTDNGIVSYSIVSQQPPRPHPQMFTIDPAKGIISVLGTGLDRETTPNYTLIVQATDQEGKGLSNTATAIIEVTDANDNIPIFNPTMYEGVVEENKPGTEVARLTVTDQDAPGSPAWQAVYHIKSGNLDGAFSIITDPSTNNGILKTAKGLDYETKSRYDLVVTVENKVPLSVPITLSTASVLVTVLDVNEPPVFVPPIKRVGVPEDLPVGQQVTSYTAQDPDRDMRQKITYRMGSDPAGWLYIHPENGIVTATQPLDRESVHAINSTYKAIILAVDNGIPDTTGTGTLLLLLQDVNDNGPTPEPRSFEICSRQPEKQILSIVDKDLPPHTYPFKAALEHGSSNNWTVEIRGQDELAMGLKKELEPGEYNIFVKLTDSQGKAQVTQVKAQVCECEGTAKNCERRSYIVGGLGVPAILGILGGILALLILLLLLLLFARRRKVEKEPLLPPEDDMRDNVYNYDEEGGGEEDQDYDLSQLHRGLDARPEVIRNDVAPPLMAAPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGGGSEATSLSSLNSSASDQDQDYDYLNEWGNRFKKLAELYGGGEDDE |
adherens junction assembly border follicle cell migration cellular response to cAMP dorsal closure germ-line stem cell population maintenance hemocyte migration imaginal disc-derived wing hair organization negative regulation of hippo signaling negative regulation of synaptic vesicle exocytosis ommatidial rotation positive regulation of cell-cell adhesion positive regulation of ERK1 and ERK2 cascade positive regulation of sevenless signaling pathway positive regulation of smoothened signaling pathway R7 cell fate commitment Rap protein signal transduction regulation of embryonic cell shape substrate-dependent cell migration, cell extension torso signaling pathway visual perception | cell leading edge; cytosol; nucleus; plasma membrane | G protein activity GDP binding GTP binding GTPase activity protein kinase binding | Drosophila melanogaster | Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome Sensory transduction Vision | MREYKIVVLG | MREYKIVVLGSGGVGKSALTVQFVQCIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLQDLREQILRVKDTDDVPMVLVGNKCDLEEERVVGKELGKNLATQFNCAFMETSAKAKVNVNDIFYDLVRQINKKSPEKKQKKPKKSLCVLL | adherens junction assembly border follicle cell migration cellular response to cAMP dorsal closure germ-line stem cell population maintenance hemocyte migration imaginal disc-derived wing hair organization negative regulation of hippo signaling negative regulation of synaptic vesicle exocytosis ommatidial rotation positive regulation of cell-cell adhesion positive regulation of ERK1 and ERK2 cascade positive regulation of sevenless signaling pathway positive regulation of smoothened signaling pathway R7 cell fate commitment Rap protein signal transduction regulation of embryonic cell shape substrate-dependent cell migration, cell extension torso signaling pathway visual perception cell leading edge; cytosol; nucleus; plasma membrane G protein activity GDP binding GTP binding GTPase activity protein kinase binding Drosophila melanogaster Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome Sensory transduction Vision MREYKIVVLG MREYKIVVLGSGGVGKSALTVQFVQCIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLQDLREQILRVKDTDDVPMVLVGNKCDLEEERVVGKELGKNLATQFNCAFMETSAKAKVNVNDIFYDLVRQINKKSPEKKQKKPKKSLCVLL |
conjugation with cellular fusion establishment or maintenance of cell polarity regulating cell shape positive regulation of conjugation with cellular fusion positive regulation of mating projection assembly positive regulation of pheromone response MAPK cascade positive regulation of protein import into nucleus protein localization to plasma membrane regulation of conjugation with cellular fusion signal transduction involved in positive regulation of conjugation with cellular fusion | Cdc42 GTPase complex; cell cortex of cell tip; cell division site; cortical dynamic polarity patch; cytoplasm; cytosol; division septum; mating projection actin fusion focus; nucleus; plasma membrane | CTP binding G protein activity GDP binding GTP binding GTPase activity protein serine/threonine kinase activator activity UTP binding | Schizosaccharomyces pombe | Cell membrane Cell shape GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MRSTYLREYK | MRSTYLREYKLVVVGDGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKKCEIDGEGALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYNITSRSSFDEISTFYQQILRVKDKDTFPVVLVANKCDLEAERVVSRAEGEQLAKSMHCLYVETSAKLRLNVEEAFYSLVRTIRRYNKSEEKGFQNKQAVQTAQVPASTAKRASAVNNSKTEDEVSTKCCVIC | conjugation with cellular fusion establishment or maintenance of cell polarity regulating cell shape positive regulation of conjugation with cellular fusion positive regulation of mating projection assembly positive regulation of pheromone response MAPK cascade positive regulation of protein import into nucleus protein localization to plasma membrane regulation of conjugation with cellular fusion signal transduction involved in positive regulation of conjugation with cellular fusion Cdc42 GTPase complex; cell cortex of cell tip; cell division site; cortical dynamic polarity patch; cytoplasm; cytosol; division septum; mating projection actin fusion focus; nucleus; plasma membrane CTP binding G protein activity GDP binding GTP binding GTPase activity protein serine/threonine kinase activator activity UTP binding Schizosaccharomyces pombe Cell membrane Cell shape GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome MRSTYLREYK MRSTYLREYKLVVVGDGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKKCEIDGEGALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYNITSRSSFDEISTFYQQILRVKDKDTFPVVLVANKCDLEAERVVSRAEGEQLAKSMHCLYVETSAKLRLNVEEAFYSLVRTIRRYNKSEEKGFQNKQAVQTAQVPASTAKRASAVNNSKTEDEVSTKCCVIC |
DNA replication negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II | chromatin; fibrillar center; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Acetylation Activator Alternative splicing Direct protein sequencing DNA replication DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MYSSPLCLTQ | MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG | DNA replication negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II chromatin; fibrillar center; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Acetylation Activator Alternative splicing Direct protein sequencing DNA replication DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MYSSPLCLTQ MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG |
homoserine biosynthetic process lysine biosynthetic process via diaminopimelate phosphorylation | cytosol | aspartate kinase activity ATP binding protein homodimerization activity | Escherichia coli | 3D-structure Allosteric enzyme Amino-acid biosynthesis ATP-binding Direct protein sequencing Kinase Lysine biosynthesis Nucleotide-binding Reference proteome Transferase | MSEIVVSKFG | MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE | homoserine biosynthetic process lysine biosynthetic process via diaminopimelate phosphorylation cytosol aspartate kinase activity ATP binding protein homodimerization activity Escherichia coli 3D-structure Allosteric enzyme Amino-acid biosynthesis ATP-binding Direct protein sequencing Kinase Lysine biosynthesis Nucleotide-binding Reference proteome Transferase MSEIVVSKFG MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE |
antiviral innate immune response cell surface pattern recognition receptor signaling pathway complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium innate immune response killing by host of symbiont cells negative regulation of viral process positive regulation of complement activation positive regulation of opsonization positive regulation of phagocytosis positive regulation of protein processing proteolysis surfactant homeostasis | collagen trimer; extracellular space; multivesicular body; protein-containing complex; serine-type endopeptidase complex | calcium ion binding calcium-dependent protein binding galactose binding identical protein binding mannose binding phosphatidylinositol-4-phosphate binding protease binding protein self-association signaling receptor binding | Rattus norvegicus | 3D-structure Calcium Coiled coil Collagen Complement activation lectin pathway Complement pathway Direct protein sequencing Disulfide bond Hydroxylation Immunity Innate immunity Lectin Mannose-binding Reference proteome Repeat Secreted Signal | MSLFTSFLLL | MSLFTSFLLLCVLTAVYAETLTEGAQSSCPVIACSSPGLNGFPGKDGHDGAKGEKGEPGQGLRGLQGPPGKVGPAGPPGNPGSKGATGPKGDRGESVEFDTTNIDLEIAALRSELRAMRKWVLLSMSENVGKKYFMSSVRRMPLNRAKALCSELQGTVATPRNAEENRAIQNVAKDVAFLGITDQRTENVFEDLTGNRVRYTNWNEGEPNNVGSGENCVVLLTNGKWNDVPCSDSFLVVCEFSD | antiviral innate immune response cell surface pattern recognition receptor signaling pathway complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium innate immune response killing by host of symbiont cells negative regulation of viral process positive regulation of complement activation positive regulation of opsonization positive regulation of phagocytosis positive regulation of protein processing proteolysis surfactant homeostasis collagen trimer; extracellular space; multivesicular body; protein-containing complex; serine-type endopeptidase complex calcium ion binding calcium-dependent protein binding galactose binding identical protein binding mannose binding phosphatidylinositol-4-phosphate binding protease binding protein self-association signaling receptor binding Rattus norvegicus 3D-structure Calcium Coiled coil Collagen Complement activation lectin pathway Complement pathway Direct protein sequencing Disulfide bond Hydroxylation Immunity Innate immunity Lectin Mannose-binding Reference proteome Repeat Secreted Signal MSLFTSFLLL MSLFTSFLLLCVLTAVYAETLTEGAQSSCPVIACSSPGLNGFPGKDGHDGAKGEKGEPGQGLRGLQGPPGKVGPAGPPGNPGSKGATGPKGDRGESVEFDTTNIDLEIAALRSELRAMRKWVLLSMSENVGKKYFMSSVRRMPLNRAKALCSELQGTVATPRNAEENRAIQNVAKDVAFLGITDQRTENVFEDLTGNRVRYTNWNEGEPNNVGSGENCVVLLTNGKWNDVPCSDSFLVVCEFSD |
fusion of virus membrane with host endosome membrane receptor-mediated endocytosis of virus by host cell virion attachment to host cell | host cell endoplasmic reticulum membrane; host cell Golgi membrane; host cell plasma membrane; membrane; viral envelope; virion membrane | metal ion binding | Lassa virus | 3D-structure Direct protein sequencing Disulfide bond Fusion of virus membrane with host endosomal membrane Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host endoplasmic reticulum Host Golgi apparatus Host membrane Host-virus interaction Lipoprotein Membrane Metal-binding Myristate Reference proteome Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virus endocytosis by host Virus entry into host cell Zinc | MGQIVTFFQE | MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQTLELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQMSIQLINKAVNALINDQLIMKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWKR | fusion of virus membrane with host endosome membrane receptor-mediated endocytosis of virus by host cell virion attachment to host cell host cell endoplasmic reticulum membrane; host cell Golgi membrane; host cell plasma membrane; membrane; viral envelope; virion membrane metal ion binding Lassa virus 3D-structure Direct protein sequencing Disulfide bond Fusion of virus membrane with host endosomal membrane Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host endoplasmic reticulum Host Golgi apparatus Host membrane Host-virus interaction Lipoprotein Membrane Metal-binding Myristate Reference proteome Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virus endocytosis by host Virus entry into host cell Zinc MGQIVTFFQE MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQTLELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQMSIQLINKAVNALINDQLIMKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWKR |
astrocyte development Bergmann glial cell differentiation cellular response to lipopolysaccharide cellular response to muramyl dipeptide cellular response to type II interferon intermediate filament organization lens fiber cell development negative regulation of neuron projection development neuron projection development positive regulation of collagen biosynthetic process positive regulation of gene expression regulation of mRNA stability | axon; cell leading edge; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intermediate filament; intermediate filament cytoskeleton; microtubule organizing center; nuclear matrix; peroxisome; phagocytic vesicle; plasma membrane | double-stranded RNA binding identical protein binding keratin filament binding molecular adaptor activity protein domain specific binding scaffold protein binding structural constituent of cytoskeleton structural constituent of eye lens | Homo sapiens | 3D-structure Acetylation Cataract Cell membrane Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Host-virus interaction Intermediate filament Isopeptide bond Membrane Nucleus Phosphoprotein Reference proteome S-nitrosylation Ubl conjugation | MSTRSVSSSS | MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE | astrocyte development Bergmann glial cell differentiation cellular response to lipopolysaccharide cellular response to muramyl dipeptide cellular response to type II interferon intermediate filament organization lens fiber cell development negative regulation of neuron projection development neuron projection development positive regulation of collagen biosynthetic process positive regulation of gene expression regulation of mRNA stability axon; cell leading edge; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intermediate filament; intermediate filament cytoskeleton; microtubule organizing center; nuclear matrix; peroxisome; phagocytic vesicle; plasma membrane double-stranded RNA binding identical protein binding keratin filament binding molecular adaptor activity protein domain specific binding scaffold protein binding structural constituent of cytoskeleton structural constituent of eye lens Homo sapiens 3D-structure Acetylation Cataract Cell membrane Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Host-virus interaction Intermediate filament Isopeptide bond Membrane Nucleus Phosphoprotein Reference proteome S-nitrosylation Ubl conjugation MSTRSVSSSS MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE |
carbohydrate metabolic process citrate metabolic process tricarboxylic acid cycle | cytoplasm; mitochondrial matrix; mitochondrion; peroxisome | citrate (Si)-synthase activity identical protein binding | Saccharomyces cerevisiae | Cytoplasm Isopeptide bond Peroxisome Phosphoprotein Reference proteome Transferase Tricarboxylic acid cycle Ubl conjugation | MTVPYLNSNR | MTVPYLNSNRNVASYLQSNSSQEKTLKERFSEIYPIHAQDVRQFVKEHGKTKISDVLLEQVYGGMRGIPGSVWEGSVLDPEDGIRFRGRTIADIQKDLPKAKGSSQPLPEALFWLLLTGEVPTQAQVENLSADLMSRSELPSHVVQLLDNLPKDLHPMAQFSIAVTALESESKFAKAYAQGISKQDYWSYTFEDSLDLLGKLPVIAAKIYRNVFKDGKMGEVDPNADYAKNLVNLIGSKDEDFVDLMRLYLTIHSDHEGGNVSAHTSHLVGSALSSPYLSLASGLNGLAGPLHGRANQEVLEWLFALKEEVNDDYSKDTIEKYLWDTLNSGRVIPGYGHAVLRKTDPRYMAQRKFAMDHFPDYELFKLVSSIYEVAPGVLTEHGKTKNPWPNVDAHSGVLLQYYGLKESSFYTVLFGVSRAFGILAQLITDRAIGASIERPKSYSTEKYKELVKNIESKL | carbohydrate metabolic process citrate metabolic process tricarboxylic acid cycle cytoplasm; mitochondrial matrix; mitochondrion; peroxisome citrate (Si)-synthase activity identical protein binding Saccharomyces cerevisiae Cytoplasm Isopeptide bond Peroxisome Phosphoprotein Reference proteome Transferase Tricarboxylic acid cycle Ubl conjugation MTVPYLNSNR MTVPYLNSNRNVASYLQSNSSQEKTLKERFSEIYPIHAQDVRQFVKEHGKTKISDVLLEQVYGGMRGIPGSVWEGSVLDPEDGIRFRGRTIADIQKDLPKAKGSSQPLPEALFWLLLTGEVPTQAQVENLSADLMSRSELPSHVVQLLDNLPKDLHPMAQFSIAVTALESESKFAKAYAQGISKQDYWSYTFEDSLDLLGKLPVIAAKIYRNVFKDGKMGEVDPNADYAKNLVNLIGSKDEDFVDLMRLYLTIHSDHEGGNVSAHTSHLVGSALSSPYLSLASGLNGLAGPLHGRANQEVLEWLFALKEEVNDDYSKDTIEKYLWDTLNSGRVIPGYGHAVLRKTDPRYMAQRKFAMDHFPDYELFKLVSSIYEVAPGVLTEHGKTKNPWPNVDAHSGVLLQYYGLKESSFYTVLFGVSRAFGILAQLITDRAIGASIERPKSYSTEKYKELVKNIESKL |
erythrocyte development erythrocyte differentiation heme biosynthetic process hemoglobin biosynthetic process intracellular iron ion homeostasis protoporphyrinogen IX biosynthetic process response to hypoxia | mitochondrial inner membrane; mitochondrial matrix; mitochondrion | 5-aminolevulinate synthase activity coenzyme A binding pyridoxal phosphate binding | Mus musculus | 3D-structure Acyltransferase Heme biosynthesis Membrane Mitochondrion Mitochondrion inner membrane Pyridoxal phosphate Reference proteome Transferase Transit peptide | MVAAAMLLRS | MVAAAMLLRSCPVLSQGPTGLLGKVAKTYQFLFSIGRCPILATQGPTCSQIHLKATKAGGDSPSWAKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTDLLSTMDSTTRSHSFPSFQEPEQTEGAVPHLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANAYPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA | erythrocyte development erythrocyte differentiation heme biosynthetic process hemoglobin biosynthetic process intracellular iron ion homeostasis protoporphyrinogen IX biosynthetic process response to hypoxia mitochondrial inner membrane; mitochondrial matrix; mitochondrion 5-aminolevulinate synthase activity coenzyme A binding pyridoxal phosphate binding Mus musculus 3D-structure Acyltransferase Heme biosynthesis Membrane Mitochondrion Mitochondrion inner membrane Pyridoxal phosphate Reference proteome Transferase Transit peptide MVAAAMLLRS MVAAAMLLRSCPVLSQGPTGLLGKVAKTYQFLFSIGRCPILATQGPTCSQIHLKATKAGGDSPSWAKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTDLLSTMDSTTRSHSFPSFQEPEQTEGAVPHLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANAYPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA |
fatty acid metabolic process | endoplasmic reticulum membrane; mitochondrial inner membrane | aromatase activity heme binding Hsp70 protein binding Hsp90 protein binding iron ion binding | Oryctolagus cuniculus | Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid metabolism Membrane Metal-binding Microsome Mitochondrion Mitochondrion inner membrane Monooxygenase NADP Oxidoreductase Reference proteome | MAVLGITVAL | MAVLGITVALLGWMVILLFISVWKQIHSSWNLPPGPFPLPIIGNLLQLDLKDIPKSFGRLAERFGPVFTVYLGSRRVVVLHGYKAVREMLLNHKNEFSGRGEIPAFREFKDKGIIFNNGPTWKDTRRFSLTTLRDYGMGKQGNEDRIQKEAHFLLEELRKTQGQPFDPTFVIGCTPFNVIAKILFNDRFDYKDKQALRLMSLFNENFYLLSTPWLQVYNNFSNYLQYMPGSHRKVIKNVSEIKEYTLARVKEHHKSLDPSCPRDFIDSLLIEMEKDKHSTEPLYTLENIAVTVADMFFAGTETTSTTLRYGLLILLKHPEIEEKLHEEIDRVIGPSRMPSVRDRVQMPYMDAVVHEIQRFIDLVPSNLPHEATRDTTFQGYVIPKGTVVIPTLDSLLYDKQEFPDPEKFKPEHFLNEEGKFKYSDYFKPFSAGKRVCVGEGLARMELFLLLSAILQHFNLKPLVDPEDIDLRNITVGFGRVPPRYKLCVIPRS | fatty acid metabolic process endoplasmic reticulum membrane; mitochondrial inner membrane aromatase activity heme binding Hsp70 protein binding Hsp90 protein binding iron ion binding Oryctolagus cuniculus Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid metabolism Membrane Metal-binding Microsome Mitochondrion Mitochondrion inner membrane Monooxygenase NADP Oxidoreductase Reference proteome MAVLGITVAL MAVLGITVALLGWMVILLFISVWKQIHSSWNLPPGPFPLPIIGNLLQLDLKDIPKSFGRLAERFGPVFTVYLGSRRVVVLHGYKAVREMLLNHKNEFSGRGEIPAFREFKDKGIIFNNGPTWKDTRRFSLTTLRDYGMGKQGNEDRIQKEAHFLLEELRKTQGQPFDPTFVIGCTPFNVIAKILFNDRFDYKDKQALRLMSLFNENFYLLSTPWLQVYNNFSNYLQYMPGSHRKVIKNVSEIKEYTLARVKEHHKSLDPSCPRDFIDSLLIEMEKDKHSTEPLYTLENIAVTVADMFFAGTETTSTTLRYGLLILLKHPEIEEKLHEEIDRVIGPSRMPSVRDRVQMPYMDAVVHEIQRFIDLVPSNLPHEATRDTTFQGYVIPKGTVVIPTLDSLLYDKQEFPDPEKFKPEHFLNEEGKFKYSDYFKPFSAGKRVCVGEGLARMELFLLLSAILQHFNLKPLVDPEDIDLRNITVGFGRVPPRYKLCVIPRS |
amide metabolic process epoxygenase P450 pathway estrogen metabolic process icosanoid biosynthetic process monocarboxylic acid metabolic process monoterpenoid metabolic process oxidative demethylation steroid metabolic process urea metabolic process xenobiotic catabolic process xenobiotic metabolic process | cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle | arachidonic acid 11,12-epoxygenase activity arachidonic acid 14,15-epoxygenase activity arachidonic acid epoxygenase activity aromatase activity caffeine oxidase activity heme binding iron ion binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity testosterone 16-alpha-hydroxylase activity | Rattus norvegicus | Direct protein sequencing Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid metabolism | MDPVLVLVLT | MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL | amide metabolic process epoxygenase P450 pathway estrogen metabolic process icosanoid biosynthetic process monocarboxylic acid metabolic process monoterpenoid metabolic process oxidative demethylation steroid metabolic process urea metabolic process xenobiotic catabolic process xenobiotic metabolic process cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle arachidonic acid 11,12-epoxygenase activity arachidonic acid 14,15-epoxygenase activity arachidonic acid epoxygenase activity aromatase activity caffeine oxidase activity heme binding iron ion binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity testosterone 16-alpha-hydroxylase activity Rattus norvegicus Direct protein sequencing Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid metabolism MDPVLVLVLT MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL |
aflatoxin metabolic process alkaloid catabolic process androgen metabolic process cholesterol metabolic process estrogen metabolic process heterocycle metabolic process lipid hydroxylation lipid metabolic process long-chain fatty acid biosynthetic process monoterpenoid metabolic process oxidative demethylation retinoic acid metabolic process retinol metabolic process steroid catabolic process steroid metabolic process vitamin D catabolic process vitamin D metabolic process xenobiotic catabolic process xenobiotic metabolic process | cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle | 1,8-cineole 2-exo-monooxygenase activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity anandamide 11,12 epoxidase activity anandamide 14,15 epoxidase activity anandamide 8,9 epoxidase activity aromatase activity caffeine oxidase activity enzyme binding estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity heme binding iron ion binding monooxygenase activity oxidoreductase activity oxygen binding quinine 3-monooxygenase activity retinoic acid 4-hydroxylase activity steroid binding steroid hydroxylase activity testosterone 6-beta-hydroxylase activity vitamin D 24-hydroxylase activity vitamin D3 25-hydroxylase activity | Homo sapiens | 3D-structure Direct protein sequencing Disease variant Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix Ubl conjugation | MALIPDLAME | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA | aflatoxin metabolic process alkaloid catabolic process androgen metabolic process cholesterol metabolic process estrogen metabolic process heterocycle metabolic process lipid hydroxylation lipid metabolic process long-chain fatty acid biosynthetic process monoterpenoid metabolic process oxidative demethylation retinoic acid metabolic process retinol metabolic process steroid catabolic process steroid metabolic process vitamin D catabolic process vitamin D metabolic process xenobiotic catabolic process xenobiotic metabolic process cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle 1,8-cineole 2-exo-monooxygenase activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity anandamide 11,12 epoxidase activity anandamide 14,15 epoxidase activity anandamide 8,9 epoxidase activity aromatase activity caffeine oxidase activity enzyme binding estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity heme binding iron ion binding monooxygenase activity oxidoreductase activity oxygen binding quinine 3-monooxygenase activity retinoic acid 4-hydroxylase activity steroid binding steroid hydroxylase activity testosterone 6-beta-hydroxylase activity vitamin D 24-hydroxylase activity vitamin D3 25-hydroxylase activity Homo sapiens 3D-structure Direct protein sequencing Disease variant Endoplasmic reticulum Fatty acid metabolism Heme Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix Ubl conjugation MALIPDLAME MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA |
glucocorticoid biosynthetic process mineralocorticoid biosynthetic process steroid biosynthetic process steroid metabolic process sterol metabolic process | endoplasmic reticulum membrane | 17-hydroxyprogesterone 21-hydroxylase activity heme binding iron ion binding progesterone 21-hydroxylase activity steroid 21-monooxygenase activity steroid binding steroid hydroxylase activity | Homo sapiens | 3D-structure Alternative splicing Congenital adrenal hyperplasia Disease variant Endoplasmic reticulum Heme Iron Lipid metabolism Lipid-binding Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid-binding Steroidogenesis | MLLLGLLLLL | MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ | glucocorticoid biosynthetic process mineralocorticoid biosynthetic process steroid biosynthetic process steroid metabolic process sterol metabolic process endoplasmic reticulum membrane 17-hydroxyprogesterone 21-hydroxylase activity heme binding iron ion binding progesterone 21-hydroxylase activity steroid 21-monooxygenase activity steroid binding steroid hydroxylase activity Homo sapiens 3D-structure Alternative splicing Congenital adrenal hyperplasia Disease variant Endoplasmic reticulum Heme Iron Lipid metabolism Lipid-binding Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome Steroid-binding Steroidogenesis MLLLGLLLLL MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ |
acute-phase response blood vessel morphogenesis collagen fibril organization fibrinolysis maintenance of blood vessel diameter homeostasis by renin-angiotensin negative regulation of fibrinolysis negative regulation of plasminogen activation positive regulation of cell differentiation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of collagen biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive regulation of smooth muscle cell proliferation positive regulation of stress fiber assembly positive regulation of transcription by RNA polymerase II positive regulation of transforming growth factor beta production response to organic substance | blood microparticle; cell surface; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule lumen | endopeptidase inhibitor activity protease binding protein homodimerization activity serine-type endopeptidase inhibitor activity | Homo sapiens | Acute phase Alternative splicing Direct protein sequencing Disease variant Disulfide bond Glycoprotein Isopeptide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal Sulfation | MALLWGLLVL | MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK | acute-phase response blood vessel morphogenesis collagen fibril organization fibrinolysis maintenance of blood vessel diameter homeostasis by renin-angiotensin negative regulation of fibrinolysis negative regulation of plasminogen activation positive regulation of cell differentiation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of collagen biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive regulation of smooth muscle cell proliferation positive regulation of stress fiber assembly positive regulation of transcription by RNA polymerase II positive regulation of transforming growth factor beta production response to organic substance blood microparticle; cell surface; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule lumen endopeptidase inhibitor activity protease binding protein homodimerization activity serine-type endopeptidase inhibitor activity Homo sapiens Acute phase Alternative splicing Direct protein sequencing Disease variant Disulfide bond Glycoprotein Isopeptide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal Sulfation MALLWGLLVL MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK |
cell-cell signaling embryonic hemopoiesis immune response interleukin-3-mediated signaling pathway nervous system development positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein | extracellular region; extracellular space | cytokine activity growth factor activity interleukin-3 receptor binding | Homo sapiens | 3D-structure Cytokine Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal | MSRLPVLLLL | MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF | cell-cell signaling embryonic hemopoiesis immune response interleukin-3-mediated signaling pathway nervous system development positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein extracellular region; extracellular space cytokine activity growth factor activity interleukin-3 receptor binding Homo sapiens 3D-structure Cytokine Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal MSRLPVLLLL MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF |
cytoplasmic translation erythrocyte homeostasis ribosomal small subunit biogenesis rRNA processing translation translational initiation | cytoplasm; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; focal adhesion; membrane; nucleolus; nucleoplasm; ribosome; small-subunit processome; synapse | RNA binding structural constituent of ribosome | Homo sapiens | 3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation | MGRVRTKTVK | MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV | cytoplasmic translation erythrocyte homeostasis ribosomal small subunit biogenesis rRNA processing translation translational initiation cytoplasm; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; focal adhesion; membrane; nucleolus; nucleoplasm; ribosome; small-subunit processome; synapse RNA binding structural constituent of ribosome Homo sapiens 3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation MGRVRTKTVK MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV |
animal organ regeneration blood coagulation circadian rhythm positive regulation of blood coagulation positive regulation of cell migration positive regulation of leukocyte chemotaxis positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of TOR signaling protein processing response to 2,3,7,8-tetrachlorodibenzodioxine response to astaxanthin response to carbon dioxide response to cholesterol response to estradiol response to estrogen response to genistein response to growth hormone response to hypoxia response to Thyroid stimulating hormone response to thyrotropin-releasing hormone response to thyroxine response to vitamin K | collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; serine-type peptidase complex; vesicle | calcium ion binding serine-type endopeptidase activity serine-type peptidase activity signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydrolase Hydroxylation Pharmaceutical Protease Reference proteome Repeat Secreted Serine protease Signal Zymogen | MVSQALRLLC | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP | animal organ regeneration blood coagulation circadian rhythm positive regulation of blood coagulation positive regulation of cell migration positive regulation of leukocyte chemotaxis positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of TOR signaling protein processing response to 2,3,7,8-tetrachlorodibenzodioxine response to astaxanthin response to carbon dioxide response to cholesterol response to estradiol response to estrogen response to genistein response to growth hormone response to hypoxia response to Thyroid stimulating hormone response to thyrotropin-releasing hormone response to thyroxine response to vitamin K collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; serine-type peptidase complex; vesicle calcium ion binding serine-type endopeptidase activity serine-type peptidase activity signaling receptor binding Homo sapiens 3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydrolase Hydroxylation Pharmaceutical Protease Reference proteome Repeat Secreted Serine protease Signal Zymogen MVSQALRLLC MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP |
protein secretion by the type I secretion system proteolysis secretion by cell toxin transport | plasma membrane; type I protein secretion system complex | ABC-type transporter activity ATP binding ATP hydrolysis activity peptidase activity toxin transmembrane transporter activity | Escherichia coli | 3D-structure ATP-binding Cell inner membrane Cell membrane Hydrolase Membrane Nucleotide-binding Plasmid Transmembrane Transmembrane helix Transport | MDSCHKIDYG | MDSCHKIDYGLYALEILAQYHNVSVNPEEIKHRFDTDGTGLGLTSWLLAAKSLELKVKQVKKTIDRLNFIFLPALVWREDGRHFILTKISKEVNRYLIFDLEQRNPRVLEQSEFEALYQGHIILITSRSSVTGKLAKFDFTWFIPAIIKYRRIFIETLVVSVFLQLFALITPLFFQVVMDKVLVHRGFSTLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSLIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVAPVIRLAQIWQDFQQVGISVTRLGDVLNSPTESYHGKLTLPEINGDITFRNIRFRYKPDSPVILDNINLSIKQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIIDNISLANPGMSVEKVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHVIMRNMHKICKGRTVIIIAHRLSTVKNADRIIVMEKGKIVEQGKHKELLSEPESLYSYLYQLQSD | protein secretion by the type I secretion system proteolysis secretion by cell toxin transport plasma membrane; type I protein secretion system complex ABC-type transporter activity ATP binding ATP hydrolysis activity peptidase activity toxin transmembrane transporter activity Escherichia coli3D-structure ATP-binding Cell inner membrane Cell membrane Hydrolase Membrane Nucleotide-binding Plasmid Transmembrane Transmembrane helix Transport MDSCHKIDYG MDSCHKIDYGLYALEILAQYHNVSVNPEEIKHRFDTDGTGLGLTSWLLAAKSLELKVKQVKKTIDRLNFIFLPALVWREDGRHFILTKISKEVNRYLIFDLEQRNPRVLEQSEFEALYQGHIILITSRSSVTGKLAKFDFTWFIPAIIKYRRIFIETLVVSVFLQLFALITPLFFQVVMDKVLVHRGFSTLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSLIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVAPVIRLAQIWQDFQQVGISVTRLGDVLNSPTESYHGKLTLPEINGDITFRNIRFRYKPDSPVILDNINLSIKQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIIDNISLANPGMSVEKVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHVIMRNMHKICKGRTVIIIAHRLSTVKNADRIIVMEKGKIVEQGKHKELLSEPESLYSYLYQLQSD |
androgen catabolic process bone mineralization calcium ion homeostasis cell adhesion cell differentiation cellular response to fluid shear stress cellular response to leukemia inhibitory factor cellular response to testosterone stimulus collecting duct development intracellular calcium ion homeostasis intracellular chloride ion homeostasis intracellular phosphate ion homeostasis intracellular sodium ion homeostasis negative regulation of collateral sprouting of intact axon in response to injury neutrophil chemotaxis osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion positive regulation of DNA-templated transcription positive regulation of estradiol secretion response to macrophage colony-stimulating factor response to organic substance response to steroid hormone response to vitamin D urate biosynthetic process | apical part of cell; cell projection; cytoplasm; extracellular space; Golgi apparatus; perinuclear region of cytoplasm; vesicle | cytokine activity extracellular matrix binding integrin binding ion binding small molecule binding | Rattus norvegicus | Biomineralization Cell adhesion Cytokine Direct protein sequencing Glycoprotein Phosphoprotein Proteoglycan Reference proteome Secreted Sialic acid Signal | MRLAVVCFCL | MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN | androgen catabolic process bone mineralization calcium ion homeostasis cell adhesion cell differentiation cellular response to fluid shear stress cellular response to leukemia inhibitory factor cellular response to testosterone stimulus collecting duct development intracellular calcium ion homeostasis intracellular chloride ion homeostasis intracellular phosphate ion homeostasis intracellular sodium ion homeostasis negative regulation of collateral sprouting of intact axon in response to injury neutrophil chemotaxis osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion positive regulation of DNA-templated transcription positive regulation of estradiol secretion response to macrophage colony-stimulating factor response to organic substance response to steroid hormone response to vitamin D urate biosynthetic process apical part of cell; cell projection; cytoplasm; extracellular space; Golgi apparatus; perinuclear region of cytoplasm; vesicle cytokine activity extracellular matrix binding integrin binding ion binding small molecule binding Rattus norvegicus Biomineralization Cell adhesion Cytokine Direct protein sequencing Glycoprotein Phosphoprotein Proteoglycan Reference proteome Secreted Sialic acid Signal MRLAVVCFCL MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN |
cell differentiation involved in embryonic placenta development epithelial cell differentiation intermediate filament organization Notch signaling pathway response to estrogen sarcomere organization | apicolateral plasma membrane; cell periphery; costamere; cytoskeleton; cytosol; extracellular exosome; intermediate filament; plasma membrane; sarcolemma; terminal web; Z disc | structural constituent of cytoskeleton structural constituent of muscle | Homo sapiens | Coiled coil Direct protein sequencing Host-virus interaction Intermediate filament Keratin Methylation Phosphoprotein Reference proteome | MTSYSYRQSS | MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL | cell differentiation involved in embryonic placenta development epithelial cell differentiation intermediate filament organization Notch signaling pathway response to estrogen sarcomere organization apicolateral plasma membrane; cell periphery; costamere; cytoskeleton; cytosol; extracellular exosome; intermediate filament; plasma membrane; sarcolemma; terminal web; Z disc structural constituent of cytoskeleton structural constituent of muscle Homo sapiens Coiled coil Direct protein sequencing Host-virus interaction Intermediate filament Keratin Methylation Phosphoprotein Reference proteome MTSYSYRQSS MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL |
intermediate filament organization keratinization | cytoplasm; cytosol; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nucleus | structural constituent of skin epidermis | Homo sapiens | 3D-structure Acetylation Coiled coil Cytoplasm Direct protein sequencing Host-virus interaction Intermediate filament Isopeptide bond Keratin Methylation Phosphoprotein Reference proteome Ubl conjugation | MSIHFSSPVF | MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD | intermediate filament organization keratinization cytoplasm; cytosol; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nucleus structural constituent of skin epidermis Homo sapiens 3D-structure Acetylation Coiled coil Cytoplasm Direct protein sequencing Host-virus interaction Intermediate filament Isopeptide bond Keratin Methylation Phosphoprotein Reference proteome Ubl conjugation MSIHFSSPVF MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD |
cellular response to retinoic acid cytoskeleton organization epithelial cell differentiation intermediate filament organization regulation of translation in response to stress tongue morphogenesis | cytoskeleton; extracellular exosome; intermediate filament cytoskeleton; keratin filament | structural molecule activity | Mus musculus | Alternative splicing Coiled coil Direct protein sequencing Glycoprotein Intermediate filament Keratin Methylation Reference proteome | MSCRFQSSSM | MSCRFQSSSMSYGGGFGAGSCQLGGGRNISSCSSRFVTGGSAGGYGGGMSCGFGGGAGGGFGGGFGGGFGGSYGGGFGGGFGDFGGVDGGLLSGNEKITMQNLNDRLASYLDKVRALEAANADLEVKIRDWHLKQSPASPERDYSAYYKTIEELRIKILEATTDNNRIILEIDNARLAADDFRLKYENELTLRQSVEADINGLRRVLDELTLAKTDLEMQIESLNEELAYLKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEALAEKNRRDAEEWFQTKSAELNKEVSSNAEMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLESTLAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMTGFNSGGNNTTTSNGSPSSNSGRPDFRKY | cellular response to retinoic acid cytoskeleton organization epithelial cell differentiation intermediate filament organization regulation of translation in response to stress tongue morphogenesis cytoskeleton; extracellular exosome; intermediate filament cytoskeleton; keratin filament structural molecule activity Mus musculus Alternative splicing Coiled coil Direct protein sequencing Glycoprotein Intermediate filament Keratin Methylation Reference proteome MSCRFQSSSM MSCRFQSSSMSYGGGFGAGSCQLGGGRNISSCSSRFVTGGSAGGYGGGMSCGFGGGAGGGFGGGFGGGFGGSYGGGFGGGFGDFGGVDGGLLSGNEKITMQNLNDRLASYLDKVRALEAANADLEVKIRDWHLKQSPASPERDYSAYYKTIEELRIKILEATTDNNRIILEIDNARLAADDFRLKYENELTLRQSVEADINGLRRVLDELTLAKTDLEMQIESLNEELAYLKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEALAEKNRRDAEEWFQTKSAELNKEVSSNAEMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLESTLAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMTGFNSGGNNTTTSNGSPSSNSGRPDFRKY |
cardiac muscle contraction cardiac myofibril assembly cell growth involved in cardiac muscle cell development heart contraction heart development heart morphogenesis muscle cell development muscle cell fate specification negative regulation of cell growth positive regulation of the force of heart contraction post-embryonic development regulation of the force of heart contraction ventricular cardiac muscle tissue morphogenesis | A band; cardiac myofibril; contractile fiber; cytoplasm; cytoskeleton; myofibril; myosin complex | actin monomer binding calcium ion binding structural constituent of muscle | Rattus norvegicus | Calcium Cytoplasm Metal-binding Methylation Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat | MSPKKAKKRL | MSPKKAKKRLEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD | cardiac muscle contraction cardiac myofibril assembly cell growth involved in cardiac muscle cell development heart contraction heart development heart morphogenesis muscle cell development muscle cell fate specification negative regulation of cell growth positive regulation of the force of heart contraction post-embryonic development regulation of the force of heart contraction ventricular cardiac muscle tissue morphogenesis A band; cardiac myofibril; contractile fiber; cytoplasm; cytoskeleton; myofibril; myosin complex actin monomer binding calcium ion binding structural constituent of muscle Rattus norvegicus Calcium Cytoplasm Metal-binding Methylation Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat MSPKKAKKRL MSPKKAKKRLEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD |
cell wall organization peptidoglycan biosynthetic process proteolysis regulation of cell shape | extracellular region; membrane raft; plasma membrane | serine-type D-Ala-D-Ala carboxypeptidase activity | Bacillus subtilis | Carboxypeptidase Cell membrane Cell shape Cell wall Cell wall biogenesis/degradation Direct protein sequencing Hydrolase Membrane Peptidoglycan synthesis Protease Reference proteome Secreted Signal | MNIKKCKQLL | MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAIMIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEISQDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKELGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETSSIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERNGMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGKEKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKDYGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF | cell wall organization peptidoglycan biosynthetic process proteolysis regulation of cell shape extracellular region; membrane raft; plasma membrane serine-type D-Ala-D-Ala carboxypeptidase activity Bacillus subtilis Carboxypeptidase Cell membrane Cell shape Cell wall Cell wall biogenesis/degradation Direct protein sequencing Hydrolase Membrane Peptidoglycan synthesis Protease Reference proteome Secreted Signal MNIKKCKQLL MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAIMIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEISQDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKELGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETSSIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERNGMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGKEKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKDYGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell cycle cell division dopamine receptor signaling pathway GTP metabolic process negative regulation of apoptotic signaling pathway negative regulation of secretion positive regulation of macroautophagy positive regulation of superoxide anion generation positive regulation of vascular associated smooth muscle cell proliferation vesicle fusion | centrosome; cytoplasm; Golgi apparatus; Golgi membrane; heterotrimeric G-protein complex; midbody; plasma membrane; zymogen granule | G protein-coupled receptor binding G protein-coupled serotonin receptor binding G-protein beta/gamma-subunit complex binding GDP binding GTP binding GTPase activating protein binding GTPase activity metal ion binding protein domain specific binding | Rattus norvegicus | 3D-structure Cell cycle Cell division Cell membrane Cytoplasm Cytoskeleton Direct protein sequencing GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Palmitate Reference proteome Transducer | MGCTLSAEDK | MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell cycle cell division dopamine receptor signaling pathway GTP metabolic process negative regulation of apoptotic signaling pathway negative regulation of secretion positive regulation of macroautophagy positive regulation of superoxide anion generation positive regulation of vascular associated smooth muscle cell proliferation vesicle fusion centrosome; cytoplasm; Golgi apparatus; Golgi membrane; heterotrimeric G-protein complex; midbody; plasma membrane; zymogen granule G protein-coupled receptor binding G protein-coupled serotonin receptor binding G-protein beta/gamma-subunit complex binding GDP binding GTP binding GTPase activating protein binding GTPase activity metal ion binding protein domain specific binding Rattus norvegicus 3D-structure Cell cycle Cell division Cell membrane Cytoplasm Cytoskeleton Direct protein sequencing GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Palmitate Reference proteome Transducer MGCTLSAEDK MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell cycle cell division dopamine receptor signaling pathway GTP metabolic process negative regulation of adenylate cyclase activity positive regulation of macroautophagy | centrosome; cytoplasm; extracellular exosome; Golgi apparatus; heterotrimeric G-protein complex; lysosomal membrane; membrane; midbody; nucleolus; nucleoplasm; plasma membrane | G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GDP binding GTP binding GTPase activity metal ion binding | Homo sapiens | 3D-structure ADP-ribosylation Cell cycle Cell division Cell membrane Cytoplasm Cytoskeleton Disease variant GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Palmitate Reference proteome Transducer | MGCTLSAEDK | MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell cycle cell division dopamine receptor signaling pathway GTP metabolic process negative regulation of adenylate cyclase activity positive regulation of macroautophagy centrosome; cytoplasm; extracellular exosome; Golgi apparatus; heterotrimeric G-protein complex; lysosomal membrane; membrane; midbody; nucleolus; nucleoplasm; plasma membrane G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GDP binding GTP binding GTPase activity metal ion binding Homo sapiens 3D-structure ADP-ribosylation Cell cycle Cell division Cell membrane Cytoplasm Cytoskeleton Disease variant GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Palmitate Reference proteome Transducer MGCTLSAEDK MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY |
blood coagulation negative regulation of apoptotic process negative regulation of coagulation response to organic substance signal transduction | collagen-containing extracellular matrix; cytoplasm; cytosol; endothelial microparticle; external side of plasma membrane; extracellular exosome; extracellular region; focal adhesion; membrane; sarcolemma | calcium ion binding calcium-dependent phospholipid binding phosphatidylserine binding phospholipase inhibitor activity phospholipid binding | Homo sapiens | 3D-structure Acetylation Annexin Blood coagulation Calcium Calcium/phospholipid-binding Direct protein sequencing Hemostasis Isopeptide bond Phosphoprotein Reference proteome Repeat S-nitrosylation Ubl conjugation | MAQVLRGTVT | MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD | blood coagulation negative regulation of apoptotic process negative regulation of coagulation response to organic substance signal transduction collagen-containing extracellular matrix; cytoplasm; cytosol; endothelial microparticle; external side of plasma membrane; extracellular exosome; extracellular region; focal adhesion; membrane; sarcolemma calcium ion binding calcium-dependent phospholipid binding phosphatidylserine binding phospholipase inhibitor activity phospholipid binding Homo sapiens 3D-structure Acetylation Annexin Blood coagulation Calcium Calcium/phospholipid-binding Direct protein sequencing Hemostasis Isopeptide bond Phosphoprotein Reference proteome Repeat S-nitrosylation Ubl conjugation MAQVLRGTVT MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD |
ADP biosynthetic process AMP metabolic process GTP metabolic process ITP metabolic process nucleoside triphosphate biosynthetic process phosphorylation UTP metabolic process | cytoplasm; mitochondrial matrix; mitochondrion | adenylate kinase activity ATP binding GTP binding nucleoside triphosphate adenylate kinase activity | Bos taurus | 3D-structure Acetylation Direct protein sequencing GTP-binding Kinase Mitochondrion Nucleotide-binding Phosphoprotein Reference proteome Transferase | MGASARLLRA | MGASARLLRAAIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRDNMLRGTEIGVLAKTFIDQGKLIPDDVMTRLVLHELKNLTQYNWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPGSGRVYNIEFNPPKTMGIDDLTGEPLVQREDDRPETVVKRLKAYEAQTEPVLEYYRKKGVLETFSGTETNKIWPHVYAFLQTKLPQRSQETSVTP | ADP biosynthetic process AMP metabolic process GTP metabolic process ITP metabolic process nucleoside triphosphate biosynthetic process phosphorylation UTP metabolic process cytoplasm; mitochondrial matrix; mitochondrion adenylate kinase activity ATP binding GTP binding nucleoside triphosphate adenylate kinase activity Bos taurus 3D-structure Acetylation Direct protein sequencing GTP-binding Kinase Mitochondrion Nucleotide-binding Phosphoprotein Reference proteome Transferase MGASARLLRA MGASARLLRAAIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRDNMLRGTEIGVLAKTFIDQGKLIPDDVMTRLVLHELKNLTQYNWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPGSGRVYNIEFNPPKTMGIDDLTGEPLVQREDDRPETVVKRLKAYEAQTEPVLEYYRKKGVLETFSGTETNKIWPHVYAFLQTKLPQRSQETSVTP |
cellular response to oxidative stress determination of adult lifespan response to oxidative stress sulfur amino acid metabolic process | cytoplasm | L-methionine-(S)-S-oxide reductase activity peptide-methionine (S)-S-oxide reductase activity | Drosophila melanogaster | Alternative splicing Disulfide bond Oxidoreductase Redox-active center Reference proteome Ubl conjugation | MSLTITSSVT | MSLTITSSVTHPELKDLSTVRNEQKELNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPTYRKMGDHTEVLEIDYDPTVISFKELLDLFWNNHEYGLTTPIKRQYASLILYHDEEQKQVAHASKLEEQERRAPEIITTEIASKENFYPAEAYHQKYRLQGHKDLASSLNLSPKLLQTSYVATKLNGYLAGVGGIEQFKAEAETMGLTPTQRQYCYYHVEQNEGQGLYC | cellular response to oxidative stress determination of adult lifespan response to oxidative stress sulfur amino acid metabolic process cytoplasm L-methionine-(S)-S-oxide reductase activity peptide-methionine (S)-S-oxide reductase activity Drosophila melanogaster Alternative splicing Disulfide bond Oxidoreductase Redox-active center Reference proteome Ubl conjugation MSLTITSSVT MSLTITSSVTHPELKDLSTVRNEQKELNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPTYRKMGDHTEVLEIDYDPTVISFKELLDLFWNNHEYGLTTPIKRQYASLILYHDEEQKQVAHASKLEEQERRAPEIITTEIASKENFYPAEAYHQKYRLQGHKDLASSLNLSPKLLQTSYVATKLNGYLAGVGGIEQFKAEAETMGLTPTQRQYCYYHVEQNEGQGLYC |
cytoskeleton organization epithelial cell differentiation establishment of skin barrier hair cycle inflammatory response innate immune response intermediate filament organization keratinization keratinocyte differentiation keratinocyte migration morphogenesis of an epithelium negative regulation of cell migration | cornified envelope; cytoskeleton; cytosol; extracellular exosome; intermediate filament; keratin filament; nucleus | structural constituent of cytoskeleton | Homo sapiens | Coiled coil Direct protein sequencing Disease variant Ectodermal dysplasia Intermediate filament Keratin Palmoplantar keratoderma Reference proteome | MTTCSRQFTS | MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS | cytoskeleton organization epithelial cell differentiation establishment of skin barrier hair cycle inflammatory response innate immune response intermediate filament organization keratinization keratinocyte differentiation keratinocyte migration morphogenesis of an epithelium negative regulation of cell migration cornified envelope; cytoskeleton; cytosol; extracellular exosome; intermediate filament; keratin filament; nucleus structural constituent of cytoskeleton Homo sapiens Coiled coil Direct protein sequencing Disease variant Ectodermal dysplasia Intermediate filament Keratin Palmoplantar keratoderma Reference proteome MTTCSRQFTS MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS |
aggregation involved in sorocarp development calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cortical actin cytoskeleton organization homophilic cell adhesion via plasma membrane adhesion molecules response to curcumin response to UV-C sorocarp development | cell surface; cell-cell junction; external side of plasma membrane; filopodium; membrane raft; plasma membrane | cell-cell adhesion mediator activity identical protein binding | Dictyostelium discoideum | Cell adhesion Cell membrane Direct protein sequencing Glycoprotein GPI-anchor Lipoprotein Membrane Phosphoprotein Reference proteome Repeat Signal | MKFLLVLIIL | MKFLLVLIILYNILNSAHSAPTITAVSNGKFGVPTYITITGTGFTGTPVVTIGGQTCDPVIVANTASLQCQFSAQLAPGNSNFDVIVKVGGVPSTGGNGLFKYTPPTLSTIFPNNGRIGMILVDGPSNISGYKLNVNDSINSAMLSVTADSVSPTIYFLVPNTIAGGLLNLELIQPFGFSTIVTSKSVFSPTITSITPLAFDLTPTNVTVTGKYFGTTASVTMGSHIYTGLTVQDDGTNCHVIFTTRSVYESSNTITAKASTGVDMIYLDNQGNQQPITFTYNPPTITSTKQVNDSVEISTTNTGTDFTQISLTMGTSSPTNLVITGTNEKIVITLPHALPEGEIQFNLKAGISNVVTSTLLVTPVINSVTQAPHNGGSITISGIFLNNAHVSIVVDQNTTDIVCAPDSNGESIICPVEAGSGTINLVVTNYKNFASDPTIKTEATTSTTYTIPDTPTPTDTATPSPTPTETATPSPTPKPTSTPEETEAPSSATTLISPLSLIVIFISFVLLI | aggregation involved in sorocarp development calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cortical actin cytoskeleton organization homophilic cell adhesion via plasma membrane adhesion molecules response to curcumin response to UV-C sorocarp development cell surface; cell-cell junction; external side of plasma membrane; filopodium; membrane raft; plasma membrane cell-cell adhesion mediator activity identical protein binding Dictyostelium discoideum Cell adhesion Cell membrane Direct protein sequencing Glycoprotein GPI-anchor Lipoprotein Membrane Phosphoprotein Reference proteome Repeat Signal MKFLLVLIIL MKFLLVLIILYNILNSAHSAPTITAVSNGKFGVPTYITITGTGFTGTPVVTIGGQTCDPVIVANTASLQCQFSAQLAPGNSNFDVIVKVGGVPSTGGNGLFKYTPPTLSTIFPNNGRIGMILVDGPSNISGYKLNVNDSINSAMLSVTADSVSPTIYFLVPNTIAGGLLNLELIQPFGFSTIVTSKSVFSPTITSITPLAFDLTPTNVTVTGKYFGTTASVTMGSHIYTGLTVQDDGTNCHVIFTTRSVYESSNTITAKASTGVDMIYLDNQGNQQPITFTYNPPTITSTKQVNDSVEISTTNTGTDFTQISLTMGTSSPTNLVITGTNEKIVITLPHALPEGEIQFNLKAGISNVVTSTLLVTPVINSVTQAPHNGGSITISGIFLNNAHVSIVVDQNTTDIVCAPDSNGESIICPVEAGSGTINLVVTNYKNFASDPTIKTEATTSTTYTIPDTPTPTDTATPSPTPTETATPSPTPKPTSTPEETEAPSSATTLISPLSLIVIFISFVLLI |
membrane fusion involved in viral entry into host cell viral entry into host cell virion attachment to host cell | host cell endosome membrane; host cell plasma membrane; membrane; viral envelope; virion membrane | structural molecule activity | Simian immunodeficiency virus | 3D-structure Apoptosis Cleavage on pair of basic residues Coiled coil Disulfide bond Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host endosome Host membrane Host-virus interaction Lipoprotein Membrane Palmitate Signal Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virus entry into host cell | MGCLGNQLLI | MGCLGNQLLIAILLLSVYGIYCTQYVTVFYGVPAWRNATIPLFCATKNRDTWGTTQCLPDNGDYSELALNVTESFDAWENTVTEQAIEDVWQLFETSIKPCVKLSPLCITMRCNKSETDRWGLTKSSTTITTAAPTSAPVSEKIDMVNETSSCIAQNNCTGLEQEQMISCKFTMTGLKRDKTKEYNETWYSTDLVCEQGNSTDNESRCYMNHCNTSVIQESCDKHYWDTIRFRYCAPPGYALLRCNDTNYSGFMPKCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKYYNLTMKCRRPGNKTVLPVTIMSGLVFHSQPINDRPKQAWCWFGGKWKDAIKEVKQTIVKHPRYTGTNNTDKINLTAPGGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRDVTTQRPKERHRRNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIANIDWTDGNQTSITMSAEVAELYRLELGDYKLVEITPIGLAPTDVKRYTTGGTSRNKRGVFVLGFLGFLATAGSAMGAASLTLTAQSRTLLAGIVQQQQQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAWGCAFRQVCHTTVPWPNASLTPDWNNDTWQEWERKVDFLEENITALLEEAQIQQEKNMYELQKLNSWDVFGNWFDLASWIKYIQYGIYVVVGVILLRIVIYIVQMLAKLRQGYRPVFSSPPSYFQXTHTQQDPALPTREGKEGDGGEGGGNSSWPWQIEYIHFLIRQLIRLLTWLFSNCRTLLSRAYQILQPILQRLSATLRRVREVLRTELTYLQYGWSYFHEAVQAGWRSATETLAGAWRDLWETLRRGGRWILAIPRRIRQGLELTLL | membrane fusion involved in viral entry into host cell viral entry into host cell virion attachment to host cell host cell endosome membrane; host cell plasma membrane; membrane; viral envelope; virion membrane structural molecule activity Simian immunodeficiency virus 3D-structure Apoptosis Cleavage on pair of basic residues Coiled coil Disulfide bond Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host endosome Host membrane Host-virus interaction Lipoprotein Membrane Palmitate Signal Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virus entry into host cell MGCLGNQLLI MGCLGNQLLIAILLLSVYGIYCTQYVTVFYGVPAWRNATIPLFCATKNRDTWGTTQCLPDNGDYSELALNVTESFDAWENTVTEQAIEDVWQLFETSIKPCVKLSPLCITMRCNKSETDRWGLTKSSTTITTAAPTSAPVSEKIDMVNETSSCIAQNNCTGLEQEQMISCKFTMTGLKRDKTKEYNETWYSTDLVCEQGNSTDNESRCYMNHCNTSVIQESCDKHYWDTIRFRYCAPPGYALLRCNDTNYSGFMPKCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKYYNLTMKCRRPGNKTVLPVTIMSGLVFHSQPINDRPKQAWCWFGGKWKDAIKEVKQTIVKHPRYTGTNNTDKINLTAPGGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRDVTTQRPKERHRRNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIANIDWTDGNQTSITMSAEVAELYRLELGDYKLVEITPIGLAPTDVKRYTTGGTSRNKRGVFVLGFLGFLATAGSAMGAASLTLTAQSRTLLAGIVQQQQQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAWGCAFRQVCHTTVPWPNASLTPDWNNDTWQEWERKVDFLEENITALLEEAQIQQEKNMYELQKLNSWDVFGNWFDLASWIKYIQYGIYVVVGVILLRIVIYIVQMLAKLRQGYRPVFSSPPSYFQXTHTQQDPALPTREGKEGDGGEGGGNSSWPWQIEYIHFLIRQLIRLLTWLFSNCRTLLSRAYQILQPILQRLSATLRRVREVLRTELTYLQYGWSYFHEAVQAGWRSATETLAGAWRDLWETLRRGGRWILAIPRRIRQGLELTLL |
proteolysis | extracellular region | serine-type carboxypeptidase activity | Hordeum vulgare | Carboxypeptidase Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Secreted Signal Zymogen | MRTTTRRLPP | MRTTTRRLPPAPAAAAVLLAALTCLLLRPAAVAAAGGHAADRIVRLPGQPEVDFDMYSGYITVDEAAGRSLFYLLQEAPEEAQPAPLVLWLNGGPGCSSVAYGASEELGAFRVMPRGAGLVLNEYRWNKVANVLFLDSPAGVGFSYTNTSSDIYTSGDNRTAHDSYAFLAAWFERFPHYKYREFYVAGESYAGHYVPELSQLVHRSGNPVINLKGFMVGNGLIDDYHDYVGTFEFWWNHGIVSDDTYRRLKDACLHDSFIHPSPACDAATDVATAEQGNIDMYSLYTPVCNISSSSSSSSLSRRRTRGRYPWLTGSYDPCTERYSTAYYNRRDVQTALHANVTGAMNYTWTNCSDTINTHWHDAPRSMLPIYRELIAAGLRIWVFSGDTDAVVPLTATRYSIGALGLATTTSWYPWYDDLQEVGGWSQVYKGLTLVSVRGAGHEVPLHRPRQALILFQQFLQGKPMPGRTTNVTVA | proteolysis extracellular region serine-type carboxypeptidase activity Hordeum vulgare Carboxypeptidase Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Secreted Signal Zymogen MRTTTRRLPP MRTTTRRLPPAPAAAAVLLAALTCLLLRPAAVAAAGGHAADRIVRLPGQPEVDFDMYSGYITVDEAAGRSLFYLLQEAPEEAQPAPLVLWLNGGPGCSSVAYGASEELGAFRVMPRGAGLVLNEYRWNKVANVLFLDSPAGVGFSYTNTSSDIYTSGDNRTAHDSYAFLAAWFERFPHYKYREFYVAGESYAGHYVPELSQLVHRSGNPVINLKGFMVGNGLIDDYHDYVGTFEFWWNHGIVSDDTYRRLKDACLHDSFIHPSPACDAATDVATAEQGNIDMYSLYTPVCNISSSSSSSSLSRRRTRGRYPWLTGSYDPCTERYSTAYYNRRDVQTALHANVTGAMNYTWTNCSDTINTHWHDAPRSMLPIYRELIAAGLRIWVFSGDTDAVVPLTATRYSIGALGLATTTSWYPWYDDLQEVGGWSQVYKGLTLVSVRGAGHEVPLHRPRQALILFQQFLQGKPMPGRTTNVTVA |
chromosome condensation | cytosol; nucleoid | DNA binding structural constituent of chromatin | Bacillus subtilis | Cytoplasm Direct protein sequencing DNA condensation DNA-binding Phosphoprotein Reference proteome | MNKTELINAV | MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQLIGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK | chromosome condensation cytosol; nucleoid DNA binding structural constituent of chromatin Bacillus subtilis Cytoplasm Direct protein sequencing DNA condensation DNA-binding Phosphoprotein Reference proteome MNKTELINAV MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQLIGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK |
insulin receptor signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of cell growth regulation of insulin-like growth factor receptor signaling pathway response to organic cyclic compound signal transduction tissue regeneration | endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus | insulin-like growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding signaling receptor binding | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Growth factor binding Phosphoprotein Reference proteome Secreted Signal | MSEVPVARVW | MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN | insulin receptor signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of cell growth regulation of insulin-like growth factor receptor signaling pathway response to organic cyclic compound signal transduction tissue regeneration endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus insulin-like growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding signaling receptor binding Homo sapiens 3D-structure Direct protein sequencing Disulfide bond Growth factor binding Phosphoprotein Reference proteome Secreted Signal MSEVPVARVW MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN |
cellular response to calcium ion starvation cellular response to starvation negative regulation of mitochondrial depolarization | cytoplasm; extracellular space; protein-containing complex | DNA binding enterobactin binding fatty acid binding metal ion binding pyridoxal phosphate binding small molecule binding toxic substance binding | Sus scrofa | Calcium Cleavage on pair of basic residues Copper Direct protein sequencing Disulfide bond Lipid-binding Metal-binding Methylation Phosphoprotein Reference proteome Repeat Secreted Signal Zinc | MKWVTFISLL | MKWVTFISLLFLFSSAYSRGVFRRDTYKSEIAHRFKDLGEQYFKGLVLIAFSQHLQQCPYEEHVKLVREVTEFAKTCVADESAENCDKSIHTLFGDKLCAIPSLREHYGDLADCCEKEEPERNECFLQHKNDNPDIPKLKPDPVALCADFQEDEQKFWGKYLYEIARRHPYFYAPELLYYAIIYKDVFSECCQAADKAACLLPKIEHLREKVLTSAAKQRLKCASIQKFGERAFKAWSLARLSQRFPKADFTEISKIVTDLAKVHKECCHGDLLECADDRADLAKYICENQDTISTKLKECCDKPLLEKSHCIAEAKRDELPADLNPLEHDFVEDKEVCKNYKEAKHVFLGTFLYEYSRRHPDYSVSLLLRIAKIYEATLEDCCAKEDPPACYATVFDKFQPLVDEPKNLIKQNCELFEKLGEYGFQNALIVRYTKKVPQVSTPTLVEVARKLGLVGSRCCKRPEEERLSCAEDYLSLVLNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYKPKEFVEGTFTFHADLCTLPEDEKQIKKQTALVELLKHKPHATEEQLRTVLGNFAAFVQKCCAAPDHEACFAVEGPKFVIEIRGILA | cellular response to calcium ion starvation cellular response to starvation negative regulation of mitochondrial depolarization cytoplasm; extracellular space; protein-containing complex DNA binding enterobactin binding fatty acid binding metal ion binding pyridoxal phosphate binding small molecule binding toxic substance binding Sus scrofa Calcium Cleavage on pair of basic residues Copper Direct protein sequencing Disulfide bond Lipid-binding Metal-binding Methylation Phosphoprotein Reference proteome Repeat Secreted Signal Zinc MKWVTFISLL MKWVTFISLLFLFSSAYSRGVFRRDTYKSEIAHRFKDLGEQYFKGLVLIAFSQHLQQCPYEEHVKLVREVTEFAKTCVADESAENCDKSIHTLFGDKLCAIPSLREHYGDLADCCEKEEPERNECFLQHKNDNPDIPKLKPDPVALCADFQEDEQKFWGKYLYEIARRHPYFYAPELLYYAIIYKDVFSECCQAADKAACLLPKIEHLREKVLTSAAKQRLKCASIQKFGERAFKAWSLARLSQRFPKADFTEISKIVTDLAKVHKECCHGDLLECADDRADLAKYICENQDTISTKLKECCDKPLLEKSHCIAEAKRDELPADLNPLEHDFVEDKEVCKNYKEAKHVFLGTFLYEYSRRHPDYSVSLLLRIAKIYEATLEDCCAKEDPPACYATVFDKFQPLVDEPKNLIKQNCELFEKLGEYGFQNALIVRYTKKVPQVSTPTLVEVARKLGLVGSRCCKRPEEERLSCAEDYLSLVLNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYKPKEFVEGTFTFHADLCTLPEDEKQIKKQTALVELLKHKPHATEEQLRTVLGNFAAFVQKCCAAPDHEACFAVEGPKFVIEIRGILA |
cholesterol biosynthetic process farnesyl diphosphate biosynthetic process geranyl diphosphate biosynthetic process | cytoplasm | dimethylallyltranstransferase activity geranyltranstransferase activity metal ion binding | Gallus gallus | 3D-structure Cholesterol biosynthesis Cholesterol metabolism Cytoplasm Direct protein sequencing Isoprene biosynthesis Lipid biosynthesis Lipid metabolism Magnesium Metal-binding Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transferase | MHKFTGVNAK | MHKFTGVNAKFQQPALRNLSPVVVEREREEFVGFFPQIVRDLTEDGIGHPEVGDAVARLKEVLQYNAPGGKCNRGLTVVAAYRELSGPGQKDAESLRCALAVGWCIELFQAFFLVADDIMDQSLTRRGQLCWYKKEGVGLDAINDSFLLESSVYRVLKKYCRQRPYYVHLLELFLQTAYQTELGQMLDLITAPVSKVDLSHFSEERYKAIVKYKTAFYSFYLPVAAAMYMVGIDSKEEHENAKAILLEMGEYFQIQDDYLDCFGDPALTGKVGTDIQDNKCSWLVVQCLQRVTPEQRQLLEDNYGRKEPEKVAKVKELYEAVGMRAAFQQYEESSYRRLQELIEKHSNRLPKEIFLGLAQKIYKRQK | cholesterol biosynthetic process farnesyl diphosphate biosynthetic process geranyl diphosphate biosynthetic process cytoplasm dimethylallyltranstransferase activity geranyltranstransferase activity metal ion binding Gallus gallus 3D-structure Cholesterol biosynthesis Cholesterol metabolism Cytoplasm Direct protein sequencing Isoprene biosynthesis Lipid biosynthesis Lipid metabolism Magnesium Metal-binding Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transferase MHKFTGVNAK MHKFTGVNAKFQQPALRNLSPVVVEREREEFVGFFPQIVRDLTEDGIGHPEVGDAVARLKEVLQYNAPGGKCNRGLTVVAAYRELSGPGQKDAESLRCALAVGWCIELFQAFFLVADDIMDQSLTRRGQLCWYKKEGVGLDAINDSFLLESSVYRVLKKYCRQRPYYVHLLELFLQTAYQTELGQMLDLITAPVSKVDLSHFSEERYKAIVKYKTAFYSFYLPVAAAMYMVGIDSKEEHENAKAILLEMGEYFQIQDDYLDCFGDPALTGKVGTDIQDNKCSWLVVQCLQRVTPEQRQLLEDNYGRKEPEKVAKVKELYEAVGMRAAFQQYEESSYRRLQELIEKHSNRLPKEIFLGLAQKIYKRQK |
phosphoenolpyruvate-dependent sugar phosphotransferase system phosphorylation | cytosol | identical protein binding kinase activity metal ion binding phosphoenolpyruvate-protein phosphotransferase activity | Escherichia coli | 3D-structure Cytoplasm Direct protein sequencing Kinase Magnesium Metal-binding Phosphotransferase system Reference proteome Sugar transport Transferase Transport | MISGILASPG | MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEVERFLSGRAKASAQLETIKTKAGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDDEYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVAADLTPSETAQLNLKKVLGFITDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMRAVQEQVASEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAIRIAMDRREILRDQLRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGKAFDESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC | phosphoenolpyruvate-dependent sugar phosphotransferase system phosphorylation cytosol identical protein binding kinase activity metal ion binding phosphoenolpyruvate-protein phosphotransferase activity Escherichia coli 3D-structure Cytoplasm Direct protein sequencing Kinase Magnesium Metal-binding Phosphotransferase system Reference proteome Sugar transport Transferase Transport MISGILASPG MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEVERFLSGRAKASAQLETIKTKAGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDDEYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVAADLTPSETAQLNLKKVLGFITDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMRAVQEQVASEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAIRIAMDRREILRDQLRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGKAFDESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC |
axon guidance axonogenesis larval behavior microtubule cytoskeleton organization mitotic cell cycle response to light stimulus | cytoplasm; microtubule | GTP binding GTPase activity metal ion binding structural constituent of cytoskeleton | Drosophila melanogaster | Cytoplasm Cytoskeleton GTP-binding Magnesium Metal-binding Microtubule Nucleotide-binding Reference proteome | MREIVNLQAG | MREIVNLQAGQCGNQIGAKFWEIISEEHGIDSNGIYVGDSDLQLERVSVYYNEASAVTRSSGGKYVPRAILLDLEPGTMESVRSGPYGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELVDNVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKVSNPSYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLAVQNKNSSYFVEWIPNNVKTAVCDIPPKGLKMSSTFIGNTTAIQELFKRISEQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADDEFDPEVNQEEVEGDCI | axon guidance axonogenesis larval behavior microtubule cytoskeleton organization mitotic cell cycle response to light stimulus cytoplasm; microtubule GTP binding GTPase activity metal ion binding structural constituent of cytoskeleton Drosophila melanogaster Cytoplasm Cytoskeleton GTP-binding Magnesium Metal-binding Microtubule Nucleotide-binding Reference proteome MREIVNLQAG MREIVNLQAGQCGNQIGAKFWEIISEEHGIDSNGIYVGDSDLQLERVSVYYNEASAVTRSSGGKYVPRAILLDLEPGTMESVRSGPYGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELVDNVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKVSNPSYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLAVQNKNSSYFVEWIPNNVKTAVCDIPPKGLKMSSTFIGNTTAIQELFKRISEQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADDEFDPEVNQEEVEGDCI |
epidermis development female pregnancy steroid catabolic process | endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; membrane; plasma membrane | arylsulfatase activity metal ion binding steryl-sulfatase activity sulfuric ester hydrolase activity | Homo sapiens | 3D-structure Calcium Cytoplasmic vesicle Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Ichthyosis Lipid metabolism Membrane Metal-binding Pregnancy Reference proteome Signal Steroid metabolism Transmembrane Transmembrane helix | MPLRKMKIPF | MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR | epidermis development female pregnancy steroid catabolic process endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; membrane; plasma membrane arylsulfatase activity metal ion binding steryl-sulfatase activity sulfuric ester hydrolase activity Homo sapiens 3D-structure Calcium Cytoplasmic vesicle Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Ichthyosis Lipid metabolism Membrane Metal-binding Pregnancy Reference proteome Signal Steroid metabolism Transmembrane Transmembrane helix MPLRKMKIPF MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR |
proteolysis | extracellular space | peptidase activity serine-type endopeptidase activity | Homo sapiens | Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Serine protease Signal Zymogen | MMLRLLSSLL | MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH | proteolysis extracellular space peptidase activity serine-type endopeptidase activity Homo sapiens Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Serine protease Signal Zymogen MMLRLLSSLL MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH |
cytoplasmic translation ribosomal small subunit assembly translation | cytoplasm; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; extracellular exosome; membrane; nucleoplasm; nucleus; plasma membrane | laminin binding laminin receptor activity ribosome binding RNA binding structural constituent of ribosome virus receptor activity | Homo sapiens | 3D-structure Acetylation Cell membrane Cytoplasm Direct protein sequencing Disease variant Host cell receptor for virus entry Host-virus interaction Isopeptide bond Membrane Nucleus Phosphoprotein Receptor Reference proteome Repeat Ribonucleoprotein Ribosomal protein Ubl conjugation | MSGALDVLQM | MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS | cytoplasmic translation ribosomal small subunit assembly translation cytoplasm; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; extracellular exosome; membrane; nucleoplasm; nucleus; plasma membrane laminin binding laminin receptor activity ribosome binding RNA binding structural constituent of ribosome virus receptor activity Homo sapiens 3D-structure Acetylation Cell membrane Cytoplasm Direct protein sequencing Disease variant Host cell receptor for virus entry Host-virus interaction Isopeptide bond Membrane Nucleus Phosphoprotein Receptor Reference proteome Repeat Ribonucleoprotein Ribosomal protein Ubl conjugation MSGALDVLQM MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS |
de novo' pyrimidine nucleobase biosynthetic process 'de novo' UMP biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleoside biosynthetic process | cytoplasm | magnesium ion binding orotate phosphoribosyltransferase activity | Salmonella typhimurium | 3D-structure Direct protein sequencing Glycosyltransferase Magnesium Pyrimidine biosynthesis Reference proteome Transferase | MKPYQRQFIE | MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV | de novo' pyrimidine nucleobase biosynthetic process 'de novo' UMP biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleoside biosynthetic process cytoplasm magnesium ion binding orotate phosphoribosyltransferase activity Salmonella typhimurium 3D-structure Direct protein sequencing Glycosyltransferase Magnesium Pyrimidine biosynthesis Reference proteome Transferase MKPYQRQFIE MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV |
arachidonic acid secretion lipid catabolic process phospholipid metabolic process | extracellular region | calcium ion binding phospholipase A2 activity toxin activity | Crotalus durissus terrificus | 3D-structure Direct protein sequencing Disulfide bond G-protein coupled receptor impairing toxin Neurotoxin Pharmaceutical Presynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Signal Toxin | MRALWIVAVL | MRALWIVAVLLVGVEGSLVEFETLMMKIAGRSGISYYSSYGCYCGAGGQGWPQDASDRCCFEHDCCYAKLTGCDPTTDVYTYRQEDGEIVCGEDDPCGTQICECDKAAAICFRNSMDTYDYKYLQFSPENCQGESQPC | arachidonic acid secretion lipid catabolic process phospholipid metabolic process extracellular region calcium ion binding phospholipase A2 activity toxin activity Crotalus durissus terrificus 3D-structure Direct protein sequencing Disulfide bond G-protein coupled receptor impairing toxin Neurotoxin Pharmaceutical Presynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Signal Toxin MRALWIVAVL MRALWIVAVLLVGVEGSLVEFETLMMKIAGRSGISYYSSYGCYCGAGGQGWPQDASDRCCFEHDCCYAKLTGCDPTTDVYTYRQEDGEIVCGEDDPCGTQICECDKAAAICFRNSMDTYDYKYLQFSPENCQGESQPC |
adherens junction organization CTP biosynthetic process epithelial cell migration, open tracheal system establishment or maintenance of polarity of follicular epithelium GTP biosynthetic process microtubule-based process mitotic cell cycle nucleotide metabolic process open tracheal system development phosphorylation regulation of tube architecture, open tracheal system UTP biosynthetic process | cytoplasm; microtubule; nuclear microtubule; plasma membrane | ATP binding GTP binding kinase activity magnesium ion binding microtubule binding nucleoside diphosphate kinase activity | Drosophila melanogaster | 3D-structure Acetylation ATP-binding Cytoplasm Cytoskeleton Direct protein sequencing Kinase Magnesium Metal-binding Microtubule Nucleotide metabolism Nucleotide-binding Phosphoprotein Reference proteome Transferase | MAANKERTFI | MAANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKFTWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEGLNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIHGSDAVESAEKEIALWFNEKELVTWTPAAKDWIYE | adherens junction organization CTP biosynthetic process epithelial cell migration, open tracheal system establishment or maintenance of polarity of follicular epithelium GTP biosynthetic process microtubule-based process mitotic cell cycle nucleotide metabolic process open tracheal system development phosphorylation regulation of tube architecture, open tracheal system UTP biosynthetic process cytoplasm; microtubule; nuclear microtubule; plasma membrane ATP binding GTP binding kinase activity magnesium ion binding microtubule binding nucleoside diphosphate kinase activity Drosophila melanogaster 3D-structure Acetylation ATP-binding Cytoplasm Cytoskeleton Direct protein sequencing Kinase Magnesium Metal-binding Microtubule Nucleotide metabolism Nucleotide-binding Phosphoprotein Reference proteome Transferase MAANKERTFI MAANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKFTWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEGLNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIHGSDAVESAEKEIALWFNEKELVTWTPAAKDWIYE |
killing of cells of another organism proteolysis | cytolytic granule; cytoplasm; intracellular membrane-bounded organelle | serine-type endopeptidase activity | Mus musculus | Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Serine protease Signal Zymogen | MPPILILLTL | MPPILILLTLLLPLRAGAEEIIGGHEVKPHSRPYMARVRFVKDNGKRHSCGGFLVQDYFVLTAAHCTGSSMRVILGAHNIRAKEETQQIIPVAKAIPHPAYDDKDNTSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGHVCSVAGWGRTSINATQRSSCLREAQLIIQKDKECKKYFYKYFKTMQICAGDPKKIQSTYSGDSGGPLVCNNKAYGVLTYGLNRTIGPGVFTKVVHYLPWISRNMKLL | killing of cells of another organism proteolysis cytolytic granule; cytoplasm; intracellular membrane-bounded organelle serine-type endopeptidase activity Mus musculus Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Serine protease Signal Zymogen MPPILILLTL MPPILILLTLLLPLRAGAEEIIGGHEVKPHSRPYMARVRFVKDNGKRHSCGGFLVQDYFVLTAAHCTGSSMRVILGAHNIRAKEETQQIIPVAKAIPHPAYDDKDNTSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGHVCSVAGWGRTSINATQRSSCLREAQLIIQKDKECKKYFYKYFKTMQICAGDPKKIQSTYSGDSGGPLVCNNKAYGVLTYGLNRTIGPGVFTKVVHYLPWISRNMKLL |
killing of cells of another organism proteolysis | cytolytic granule; cytoplasm; intracellular membrane-bounded organelle | serine-type endopeptidase activity | Mus musculus | Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Serine protease Signal Zymogen | MPPVLILLTL | MPPVLILLTLLLPLGAGAEEIIGGHVVKPHSRPYMAFVKSVDIEGNRRYCGGFLVQDDFVLTAAHCRNRTMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYNATAFFSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGDVCSVAGWGSRSINDTKASARLREAQLVIQEDEECKKRFRHYTETTEICAGDLKKIKTPFKGDSGGPLVCDNKAYGLLAYAKNRTISSGVFTKIVHFLPWISRNMKLL | killing of cells of another organism proteolysis cytolytic granule; cytoplasm; intracellular membrane-bounded organelle serine-type endopeptidase activity Mus musculus Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Serine protease Signal Zymogen MPPVLILLTL MPPVLILLTLLLPLGAGAEEIIGGHVVKPHSRPYMAFVKSVDIEGNRRYCGGFLVQDDFVLTAAHCRNRTMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYNATAFFSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGDVCSVAGWGSRSINDTKASARLREAQLVIQEDEECKKRFRHYTETTEICAGDLKKIKTPFKGDSGGPLVCDNKAYGLLAYAKNRTISSGVFTKIVHFLPWISRNMKLL |
collagen catabolic process proteolysis | extracellular region | serine-type endopeptidase activity | Hypoderma lineatum | 3D-structure Collagen degradation Direct protein sequencing Disulfide bond Hydrolase Protease Secreted Serine protease Signal Zymogen | MKFLLVFALA | MKFLLVFALALATTSAFQHPASIFELREGRIINGYEAYTGLFPYQAGLDITLQDQRRVWCGGSLIDNKWILTAAHCVHDAVSVVVYLGSAVQYEGEAVVNSERIISHSMFNPDTYLNDVALIKIPHVEYTDNIQPIRLPSGEELNNKFENIWATVSGWGQSNTDTVILQYTYNLVIDNDRCAQEYPPGIIVESTICGDTCDGKSPCFGDSGGPFVLSDKNLLIGVVSFVSGAGCESGKPVGFSRVTSYMDWIQQNTGIIF | collagen catabolic process proteolysis extracellular region serine-type endopeptidase activity Hypoderma lineatum 3D-structure Collagen degradation Direct protein sequencing Disulfide bond Hydrolase Protease Secreted Serine protease Signal Zymogen MKFLLVFALA MKFLLVFALALATTSAFQHPASIFELREGRIINGYEAYTGLFPYQAGLDITLQDQRRVWCGGSLIDNKWILTAAHCVHDAVSVVVYLGSAVQYEGEAVVNSERIISHSMFNPDTYLNDVALIKIPHVEYTDNIQPIRLPSGEELNNKFENIWATVSGWGQSNTDTVILQYTYNLVIDNDRCAQEYPPGIIVESTICGDTCDGKSPCFGDSGGPFVLSDKNLLIGVVSFVSGAGCESGKPVGFSRVTSYMDWIQQNTGIIF |
defense response | extracellular space | sodium channel inhibitor activity toxin activity | Centruroides suffusus | 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin | KEGYLVSKST | KEGYLVSKSTGCKYECLKLGDNDYCLRECKQQYGKSSGGYCYAFACWCTHLYEQAVVWPLPNKTCN | defense response extracellular space sodium channel inhibitor activity toxin activity Centruroides suffusus 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin KEGYLVSKST KEGYLVSKSTGCKYECLKLGDNDYCLRECKQQYGKSSGGYCYAFACWCTHLYEQAVVWPLPNKTCN |
antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to Gram-negative bacterium defense response to Gram-positive bacterium innate immune response | extracellular space; lysosome | endonuclease activity nucleic acid binding RNA nuclease activity | Bos taurus | Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Endonuclease Glycoprotein Hydrolase Lysosome Nuclease Reference proteome Secreted Signal | MGPHLLGRSS | MGPHLLGRSSLLLLLLGMWWSVRPLCAVPKGLTKARWFEIQHIQPRLLQCNKAMSGVNNYTQHCKPENTFLHNVFQDVTAVCDMPNIICKNGRHNCHQSPKPVNLTQCNFIAGRYPDCRYHDDAQYKFFIVACDPPQKTDPPYHLVPVHLDKVV | antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to Gram-negative bacterium defense response to Gram-positive bacterium innate immune response extracellular space; lysosome endonuclease activity nucleic acid binding RNA nuclease activity Bos taurus Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Endonuclease Glycoprotein Hydrolase Lysosome Nuclease Reference proteome Secreted Signal MGPHLLGRSS MGPHLLGRSSLLLLLLGMWWSVRPLCAVPKGLTKARWFEIQHIQPRLLQCNKAMSGVNNYTQHCKPENTFLHNVFQDVTAVCDMPNIICKNGRHNCHQSPKPVNLTQCNFIAGRYPDCRYHDDAQYKFFIVACDPPQKTDPPYHLVPVHLDKVV |
defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium killing of cells of another organism metabolic process | endoplasmic reticulum lumen; extracellular space; Golgi cis cisterna; Golgi stack; microvillus; rough endoplasmic reticulum lumen; secretory granule; trans-Golgi network transport vesicle | hydrolase activity, acting on glycosyl bonds identical protein binding lysozyme activity | Mus musculus | 3D-structure Antimicrobial Bacteriolytic enzyme Direct protein sequencing Disulfide bond Glycosidase Hydrolase Milk protein Reference proteome Secreted Signal | MKTLLTLGLL | MKTLLTLGLLLLSVTAQAKVYERCEFARTLKRNGMAGYYGVSLADWVCLAQHESNYNTRATNYNRGDQSTDYGIFQINSRYWCNDGKTPRAVNACGINCSALLQDDITAAIQCAKRVVRDPQGIRAWVAWRAHCQNRDLSQYIRNCGV | defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium killing of cells of another organism metabolic process endoplasmic reticulum lumen; extracellular space; Golgi cis cisterna; Golgi stack; microvillus; rough endoplasmic reticulum lumen; secretory granule; trans-Golgi network transport vesicle hydrolase activity, acting on glycosyl bonds identical protein binding lysozyme activity Mus musculus 3D-structure Antimicrobial Bacteriolytic enzyme Direct protein sequencing Disulfide bond Glycosidase Hydrolase Milk protein Reference proteome Secreted Signal MKTLLTLGLL MKTLLTLGLLLLSVTAQAKVYERCEFARTLKRNGMAGYYGVSLADWVCLAQHESNYNTRATNYNRGDQSTDYGIFQINSRYWCNDGKTPRAVNACGINCSALLQDDITAAIQCAKRVVRDPQGIRAWVAWRAHCQNRDLSQYIRNCGV |
aspartate biosynthetic process glycerol biosynthetic process | cytosol | L-aspartate:2-oxoglutarate aminotransferase activity L-cysteine transaminase activity pyridoxal phosphate binding | Equus caballus | Acetylation Amino-acid biosynthesis Aminotransferase Cytoplasm Direct protein sequencing Phosphoprotein Pyridoxal phosphate Reference proteome Transferase | MTSPSIFVEV | MTSPSIFVEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQKIANNSSLNHEYLPILGLAEFRSCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLSRWYNGTNNKNTPVYVSSPTWENHNGVFSGAGFKDIRSYHYWDATKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLDRDAWAVRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMQKIVRITWSNPPAQGARIVAFTLSDPGLFKEWTGNVKTMADRILSMRSELRARLEALKTPGTWNHITEQIGMFSFTGLNPKQVEYLVNQKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKFQ | aspartate biosynthetic process glycerol biosynthetic process cytosol L-aspartate:2-oxoglutarate aminotransferase activity L-cysteine transaminase activity pyridoxal phosphate binding Equus caballus Acetylation Amino-acid biosynthesis Aminotransferase Cytoplasm Direct protein sequencing Phosphoprotein Pyridoxal phosphate Reference proteome Transferase MTSPSIFVEV MTSPSIFVEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQKIANNSSLNHEYLPILGLAEFRSCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLSRWYNGTNNKNTPVYVSSPTWENHNGVFSGAGFKDIRSYHYWDATKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLDRDAWAVRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMQKIVRITWSNPPAQGARIVAFTLSDPGLFKEWTGNVKTMADRILSMRSELRARLEALKTPGTWNHITEQIGMFSFTGLNPKQVEYLVNQKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKFQ |
2-oxoglutarate metabolic process aspartate catabolic process aspartate metabolic process biosynthetic process glutamate metabolic process lipid transport | mitochondrial matrix; mitochondrion; plasma membrane | kynurenine-oxoglutarate transaminase activity L-aspartate:2-oxoglutarate aminotransferase activity pyridoxal phosphate binding | Equus caballus | Acetylation Aminotransferase Cell membrane Direct protein sequencing Lipid transport Membrane Methylation Mitochondrion Nitration Phosphoprotein Pyridoxal phosphate Reference proteome Transferase Transport | SSWWAHVEMG | SSWWAHVEMGPPDPILGVTEAYKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEALKSGRYVTVQSISGTGALRIGANFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGLQLHAYRYYDPKTCGFDVTGALEDISKIPQQSIILLHACAHNPTGVDPRPEQWKEIATLVKKNNLFAFFDMAYQGFASGDGNKDAWAVRYFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPLYSNPPLNGARIASTILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHSWQHIADQIGMFCFTGLKPEQVERLTKEFSIYMTKDGRISVAGVTSGNVGYLAHAIHQVTK | 2-oxoglutarate metabolic process aspartate catabolic process aspartate metabolic process biosynthetic process glutamate metabolic process lipid transport mitochondrial matrix; mitochondrion; plasma membrane kynurenine-oxoglutarate transaminase activity L-aspartate:2-oxoglutarate aminotransferase activity pyridoxal phosphate binding Equus caballus Acetylation Aminotransferase Cell membrane Direct protein sequencing Lipid transport Membrane Methylation Mitochondrion Nitration Phosphoprotein Pyridoxal phosphate Reference proteome Transferase Transport SSWWAHVEMG SSWWAHVEMGPPDPILGVTEAYKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEALKSGRYVTVQSISGTGALRIGANFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGLQLHAYRYYDPKTCGFDVTGALEDISKIPQQSIILLHACAHNPTGVDPRPEQWKEIATLVKKNNLFAFFDMAYQGFASGDGNKDAWAVRYFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPLYSNPPLNGARIASTILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHSWQHIADQIGMFCFTGLKPEQVERLTKEFSIYMTKDGRISVAGVTSGNVGYLAHAIHQVTK |
adenylate cyclase-inhibiting serotonin receptor signaling pathway behavioral fear response chemical synaptic transmission exploration behavior G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gamma-aminobutyric acid signaling pathway positive regulation of cell population proliferation regulation of behavior regulation of dopamine metabolic process regulation of hormone secretion regulation of serotonin secretion regulation of vasoconstriction serotonin metabolic process serotonin receptor signaling pathway | dendrite; plasma membrane; synapse | G protein-coupled serotonin receptor activity neurotransmitter receptor activity receptor-receptor interaction serotonin binding | Homo sapiens | 3D-structure Behavior Cell membrane Cell projection Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MDVLSPGQGN | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ | adenylate cyclase-inhibiting serotonin receptor signaling pathway behavioral fear response chemical synaptic transmission exploration behavior G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gamma-aminobutyric acid signaling pathway positive regulation of cell population proliferation regulation of behavior regulation of dopamine metabolic process regulation of hormone secretion regulation of serotonin secretion regulation of vasoconstriction serotonin metabolic process serotonin receptor signaling pathway dendrite; plasma membrane; synapse G protein-coupled serotonin receptor activity neurotransmitter receptor activity receptor-receptor interaction serotonin binding Homo sapiens 3D-structure Behavior Cell membrane Cell projection Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix MDVLSPGQGN MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
acrosome reaction acylglycerol catabolic process medium-chain fatty acid biosynthetic process medium-chain fatty acid catabolic process negative regulation of smooth muscle cell migration response to progesterone response to wounding smooth muscle cell migration sperm capacitation steroid hormone mediated signaling pathway | acrosomal vesicle; sperm flagellum; sperm plasma membrane | acetylesterase activity acylglycerol lipase activity hormone binding hormone-sensitive lipase activity nuclear steroid receptor activity triglyceride lipase activity | Homo sapiens | Cell membrane Cell projection Cilium Flagellum Glycoprotein Hydrolase Lipid degradation Lipid metabolism Membrane Reference proteome Serine esterase Signal-anchor Transmembrane Transmembrane helix | MNAMLETPEL | MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE | acrosome reaction acylglycerol catabolic process medium-chain fatty acid biosynthetic process medium-chain fatty acid catabolic process negative regulation of smooth muscle cell migration response to progesterone response to wounding smooth muscle cell migration sperm capacitation steroid hormone mediated signaling pathway acrosomal vesicle; sperm flagellum; sperm plasma membrane acetylesterase activity acylglycerol lipase activity hormone binding hormone-sensitive lipase activity nuclear steroid receptor activity triglyceride lipase activity Homo sapiens Cell membrane Cell projection Cilium Flagellum Glycoprotein Hydrolase Lipid degradation Lipid metabolism Membrane Reference proteome Serine esterase Signal-anchor Transmembrane Transmembrane helix MNAMLETPEL MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE |
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway chemical synaptic transmission dopamine transport G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gastric acid secretion regulation of phosphatidylinositol dephosphorylation transmission of nerve impulse | dendrite; postsynaptic membrane; synapse | G protein-coupled acetylcholine receptor activity G protein-coupled serotonin receptor activity | Rattus norvegicus | Cell membrane Direct protein sequencing Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix | MEGESYNEST | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway chemical synaptic transmission dopamine transport G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gastric acid secretion regulation of phosphatidylinositol dephosphorylation transmission of nerve impulse dendrite; postsynaptic membrane; synapse G protein-coupled acetylcholine receptor activity G protein-coupled serotonin receptor activity Rattus norvegicus Cell membrane Direct protein sequencing Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix MEGESYNEST MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP |
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway chemical synaptic transmission dopamine transport G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gastric acid secretion regulation of phosphatidylinositol dephosphorylation transmission of nerve impulse | dendrite; plasma membrane; postsynaptic membrane; synapse | G protein-coupled acetylcholine receptor activity G protein-coupled serotonin receptor activity phosphatidylinositol phospholipase C activity | Homo sapiens | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix | MEGDSYHNAT | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway chemical synaptic transmission dopamine transport G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger gastric acid secretion regulation of phosphatidylinositol dephosphorylation transmission of nerve impulse dendrite; plasma membrane; postsynaptic membrane; synapse G protein-coupled acetylcholine receptor activity G protein-coupled serotonin receptor activity phosphatidylinositol phospholipase C activity Homo sapiens 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix MEGDSYHNAT MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP |
cell-cell adhesion heterotypic cell-cell adhesion natural killer cell activation natural killer cell mediated cytotoxicity positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of type II interferon production | cell surface; cell-cell junction; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; Golgi apparatus; nucleoplasm; plasma membrane; protein-containing complex | identical protein binding protein kinase binding protein self-association receptor tyrosine kinase binding signaling receptor binding | Mus musculus | Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix | MKCKFLGSFF | MKCKFLGSFFLLFSLSGKGADCRDNETIWGVLGHGITLNIPNFQMTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAPPPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN | cell-cell adhesion heterotypic cell-cell adhesion natural killer cell activation natural killer cell mediated cytotoxicity positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of type II interferon production cell surface; cell-cell junction; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; Golgi apparatus; nucleoplasm; plasma membrane; protein-containing complex identical protein binding protein kinase binding protein self-association receptor tyrosine kinase binding signaling receptor binding Mus musculus Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix MKCKFLGSFF MKCKFLGSFFLLFSLSGKGADCRDNETIWGVLGHGITLNIPNFQMTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAPPPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN |
cell-cell adhesion heterotypic cell-cell adhesion natural killer cell activation natural killer cell mediated cytotoxicity positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of type II interferon production | cell surface; cell-cell junction; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; Golgi apparatus; nucleoplasm; plasma membrane; protein-containing complex | identical protein binding protein kinase binding protein self-association receptor tyrosine kinase binding signaling receptor binding | Rattus norvegicus | 3D-structure Cell adhesion Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix | MRCKFLGSFF | MRCKFLGSFFLLFSLSSKGADCRDSGTVWGALGHGINLNIPNFQMTDDIDEVRWERGSTLVAEFKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMIYWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVNCPEKGLPLYLIVGVSAGGLLLVFFGALFIFCICKRKKRNRRRKGEELEIKASRMSTVERGPKPHSTQASAPASQNPVASQAPPPPGHHLQTPGHRPLPPSHRNREHQPKKRPPPSGTQVHQQKGPPLPRPRVQPKPPCGSGDVSLPPPN | cell-cell adhesion heterotypic cell-cell adhesion natural killer cell activation natural killer cell mediated cytotoxicity positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of type II interferon production cell surface; cell-cell junction; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; Golgi apparatus; nucleoplasm; plasma membrane; protein-containing complex identical protein binding protein kinase binding protein self-association receptor tyrosine kinase binding signaling receptor binding Rattus norvegicus 3D-structure Cell adhesion Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix MRCKFLGSFF MRCKFLGSFFLLFSLSSKGADCRDSGTVWGALGHGINLNIPNFQMTDDIDEVRWERGSTLVAEFKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMIYWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVNCPEKGLPLYLIVGVSAGGLLLVFFGALFIFCICKRKKRNRRRKGEELEIKASRMSTVERGPKPHSTQASAPASQNPVASQAPPPPGHHLQTPGHRPLPPSHRNREHQPKKRPPPSGTQVHQQKGPPLPRPRVQPKPPCGSGDVSLPPPN |
cell population proliferation cellular response to retinoic acid negative regulation of apoptotic process peptidyl-tyrosine autophosphorylation positive regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell population proliferation regulation of neuron differentiation transmembrane receptor protein tyrosine kinase signaling pathway | endoplasmic reticulum; membrane; plasma membrane; receptor complex | ATP binding protein kinase activity receptor signaling protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activity | Mus musculus | Alternative promoter usage Alternative splicing ATP-binding Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Kinase Membrane Nucleotide-binding Phosphoprotein Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase | MGCSHRLLLW | MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ | cell population proliferation cellular response to retinoic acid negative regulation of apoptotic process peptidyl-tyrosine autophosphorylation positive regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell population proliferation regulation of neuron differentiation transmembrane receptor protein tyrosine kinase signaling pathway endoplasmic reticulum; membrane; plasma membrane; receptor complex ATP binding protein kinase activity receptor signaling protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activity Mus musculus Alternative promoter usage Alternative splicing ATP-binding Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Kinase Membrane Nucleotide-binding Phosphoprotein Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase MGCSHRLLLW MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ |
central nervous system development chitin-based cuticle development compound eye morphogenesis digestive tract morphogenesis gonad morphogenesis heterochromatin formation heterochromatin organization male meiosis cytokinesis meiosis I cytokinesis mitotic nuclear membrane reassembly negative regulation of cell population proliferation negative regulation of immune response nuclear envelope organization nuclear membrane organization nuclear migration nuclear pore localization nucleus organization positive regulation of actin filament polymerization positive regulation of cytokinesis, actomyosin contractile ring assembly positive regulation of protein localization to nucleus positive regulation of spindle assembly protein localization to nuclear envelope spermatocyte division spermatogenesis terminal branching, open tracheal system | cytoplasm; lamin filament; nuclear envelope; nuclear envelope lumen; nuclear inner membrane; nuclear lamina; nucleus; spindle pole | chromatin binding signaling receptor binding structural constituent of cytoskeleton | Drosophila melanogaster | Acetylation Coiled coil Cytoplasm Cytoskeleton Intermediate filament Lipoprotein Membrane Methylation Nucleus Phosphoprotein Prenylation Reference proteome | MSSKSRRAGT | MSSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQKWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAIM | central nervous system development chitin-based cuticle development compound eye morphogenesis digestive tract morphogenesis gonad morphogenesis heterochromatin formation heterochromatin organization male meiosis cytokinesis meiosis I cytokinesis mitotic nuclear membrane reassembly negative regulation of cell population proliferation negative regulation of immune response nuclear envelope organization nuclear membrane organization nuclear migration nuclear pore localization nucleus organization positive regulation of actin filament polymerization positive regulation of cytokinesis, actomyosin contractile ring assembly positive regulation of protein localization to nucleus positive regulation of spindle assembly protein localization to nuclear envelope spermatocyte division spermatogenesis terminal branching, open tracheal system cytoplasm; lamin filament; nuclear envelope; nuclear envelope lumen; nuclear inner membrane; nuclear lamina; nucleus; spindle pole chromatin binding signaling receptor binding structural constituent of cytoskeleton Drosophila melanogaster Acetylation Coiled coil Cytoplasm Cytoskeleton Intermediate filament Lipoprotein Membrane Methylation Nucleus Phosphoprotein Prenylation Reference proteome MSSKSRRAGT MSSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQKWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAIM |
blood coagulation Factor XII activation negative regulation of blood coagulation negative regulation of lymphocyte proliferation negative regulation of proteolysis negative regulation of T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of endothelial cell proliferation positive regulation of fibroblast proliferation positive regulation of MAPK cascade signal transduction vasodilation | extracellular region; extracellular space; perikaryon | cysteine-type endopeptidase inhibitor activity protease binding | Rattus norvegicus | Alternative splicing Blood coagulation Disulfide bond Glycoprotein Hemostasis Inflammatory response Phosphoprotein Protease inhibitor Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator | MKLITILLLC | MKLITILLLCSRLLPSLAQEEDAQEMDCNDESLFQAVDTALKKYNAGLKSGNQFVLYQVTEGTKKDGSKTFYSFKYQIKEGNCSVQSGFAWQDCDFKDAEEAATGECTATLEKRRNNKFSIATQICNITPGKGPIVTNEYHCLGCMHPISVDSPELGPVLKHAVEHFNNNTKHTHLFALGEVKSADRQVVAGMNYQIIYSIVQTNCSKEDFPSLHEDCVPLPSGDDGECKGNAFVDIHKTIAGFSDSCEFYPGDDLFELLPEDCPGCPRNIPVDSPELKEALGHSIAQLNAENNHTFYFKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNAELTADCETKRLGQSLNCNANVYMRPWENKVVPTVKCKVLDMTSVIRRPPGFSPFRAPRVKKPKESTTVSPSYIARVQEERDPGNEQGPIHGHGWLHAKQIKNKNHQGHKHGHGIGHGHQKPHGLGHGHQLKLDDLKQQREDGYDHRHPVGHGHGQRHGHGHGHGHGRDKHTNKDKNNVKHTDQRRAPLTSSSEDNTTSTQIQGRTEGFTLNPPLAQPAVISRGFQDSGFTEGVIATTSPYDTETHDDLIPDIHVQPDSLSFKLISDFPEATSHKCPGRPWKPVSRKDPTIETTEFSDFDLLDALS | blood coagulation Factor XII activation negative regulation of blood coagulation negative regulation of lymphocyte proliferation negative regulation of proteolysis negative regulation of T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of endothelial cell proliferation positive regulation of fibroblast proliferation positive regulation of MAPK cascade signal transduction vasodilation extracellular region; extracellular space; perikaryon cysteine-type endopeptidase inhibitor activity protease binding Rattus norvegicus Alternative splicing Blood coagulation Disulfide bond Glycoprotein Hemostasis Inflammatory response Phosphoprotein Protease inhibitor Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator MKLITILLLC MKLITILLLCSRLLPSLAQEEDAQEMDCNDESLFQAVDTALKKYNAGLKSGNQFVLYQVTEGTKKDGSKTFYSFKYQIKEGNCSVQSGFAWQDCDFKDAEEAATGECTATLEKRRNNKFSIATQICNITPGKGPIVTNEYHCLGCMHPISVDSPELGPVLKHAVEHFNNNTKHTHLFALGEVKSADRQVVAGMNYQIIYSIVQTNCSKEDFPSLHEDCVPLPSGDDGECKGNAFVDIHKTIAGFSDSCEFYPGDDLFELLPEDCPGCPRNIPVDSPELKEALGHSIAQLNAENNHTFYFKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNAELTADCETKRLGQSLNCNANVYMRPWENKVVPTVKCKVLDMTSVIRRPPGFSPFRAPRVKKPKESTTVSPSYIARVQEERDPGNEQGPIHGHGWLHAKQIKNKNHQGHKHGHGIGHGHQKPHGLGHGHQLKLDDLKQQREDGYDHRHPVGHGHGQRHGHGHGHGHGRDKHTNKDKNNVKHTDQRRAPLTSSSEDNTTSTQIQGRTEGFTLNPPLAQPAVISRGFQDSGFTEGVIATTSPYDTETHDDLIPDIHVQPDSLSFKLISDFPEATSHKCPGRPWKPVSRKDPTIETTEFSDFDLLDALS |
antiviral innate immune response arachidonic acid secretion cell-cell signaling Leydig cell proliferation negative regulation of hormone secretion negative regulation of interleukin-6 production neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of hormone secretion positive regulation of interferon-alpha production positive regulation of osteoclast proliferation positive regulation of respiratory gaseous exchange positive regulation of testosterone secretion sensory perception of itch signal transduction sneeze reflex | extracellular region; extracellular space; neuron projection | hormone activity neuromedin B receptor binding neuropeptide hormone activity | Homo sapiens | 3D-structure Alternative splicing Amidation Cell projection Cleavage on pair of basic residues Immunity Innate immunity Reference proteome Secreted Signal | MARRAGGARM | MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK | antiviral innate immune response arachidonic acid secretion cell-cell signaling Leydig cell proliferation negative regulation of hormone secretion negative regulation of interleukin-6 production neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of hormone secretion positive regulation of interferon-alpha production positive regulation of osteoclast proliferation positive regulation of respiratory gaseous exchange positive regulation of testosterone secretion sensory perception of itch signal transduction sneeze reflex extracellular region; extracellular space; neuron projection hormone activity neuromedin B receptor binding neuropeptide hormone activity Homo sapiens 3D-structure Alternative splicing Amidation Cell projection Cleavage on pair of basic residues Immunity Innate immunity Reference proteome Secreted Signal MARRAGGARM MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK |
meiotic cell cycle negative regulation of conjugation with zygote positive regulation of meiotic cell cycle positive regulation of metaphase/anaphase transition of meiosis II signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle | cytoplasm; cytosol; Mei2 nuclear dot complex; nuclear chromosome; nucleus; Tor2-Mei2-Ste11 complex | lncRNA binding poly(U) RNA binding protein sequestering activity RNA binding | Schizosaccharomyces pombe | 3D-structure Meiosis Phosphoprotein Reference proteome Repeat RNA-binding Stress response | MIMETESPLS | MIMETESPLSITSPSPSDSTFQVDMEKTMHALPSSLLDSPLLSTNEHYPPKSTLLLSGPSPIRNIQLSATKSSESNSIDYLTDTQNIFPNFVNNENNYQFSTAPLNPIDACRVGERKVFTTGNVLLSADRQPLSTWQQNISVLSESPPQNGIQSYISSSEQAAQALTRKPSVTGFRSSSLNSNSDDIDIFSHASRYLFVTNLPRIVPYATLLELFSKLGDVKGIDTSSLSTDGICIVAFFDIRQAIQAAKSLRSQRFFNDRLLYFQFCQRSSIQKMINQGATIQFLDDNEGQLLLNMQGGSVLSILQLQSILQTFGPLLIMKPLRSQNVSQIICEFYDTRDASFALDELDGRIIHNCCLQVAYYDAMADSVSTSSASSLSVPRGFSGMLNNNSEWNNSMTMSSNQETPTAASCAVSRIGSSYGMSNNFGSVPLGRTESSPAWGTSGYYDVSSTSPVAPSDRNPSRQYNSIRYGLDVNPIAPPNSSRLKQRNSDLLNGINPQWSPFSSNTGKVFDSPTGSLGMRRSLTVGANASCSNPTNLSFASLTLHDSKADSTLSASSLNPDLNLQRYTPTVEKHASDRNSVDYAQIASGIDTRTTVMIKNIPNKFTQQMLRDYIDVTNKGTYDFLYLRIDFVNKCNVGYAFINFIEPQSIITFGKARVGTQWNVFHSEKICDISYANIQGKDRLIEKFRNSCVMDENPAYRPKIFVSHGPNRGMEEPFPAPNNARRKLRSIASAQQIGLFPPTASKC | meiotic cell cycle negative regulation of conjugation with zygote positive regulation of meiotic cell cycle positive regulation of metaphase/anaphase transition of meiosis II signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle cytoplasm; cytosol; Mei2 nuclear dot complex; nuclear chromosome; nucleus; Tor2-Mei2-Ste11 complex lncRNA binding poly(U) RNA binding protein sequestering activity RNA binding Schizosaccharomyces pombe 3D-structure Meiosis Phosphoprotein Reference proteome Repeat RNA-binding Stress response MIMETESPLS MIMETESPLSITSPSPSDSTFQVDMEKTMHALPSSLLDSPLLSTNEHYPPKSTLLLSGPSPIRNIQLSATKSSESNSIDYLTDTQNIFPNFVNNENNYQFSTAPLNPIDACRVGERKVFTTGNVLLSADRQPLSTWQQNISVLSESPPQNGIQSYISSSEQAAQALTRKPSVTGFRSSSLNSNSDDIDIFSHASRYLFVTNLPRIVPYATLLELFSKLGDVKGIDTSSLSTDGICIVAFFDIRQAIQAAKSLRSQRFFNDRLLYFQFCQRSSIQKMINQGATIQFLDDNEGQLLLNMQGGSVLSILQLQSILQTFGPLLIMKPLRSQNVSQIICEFYDTRDASFALDELDGRIIHNCCLQVAYYDAMADSVSTSSASSLSVPRGFSGMLNNNSEWNNSMTMSSNQETPTAASCAVSRIGSSYGMSNNFGSVPLGRTESSPAWGTSGYYDVSSTSPVAPSDRNPSRQYNSIRYGLDVNPIAPPNSSRLKQRNSDLLNGINPQWSPFSSNTGKVFDSPTGSLGMRRSLTVGANASCSNPTNLSFASLTLHDSKADSTLSASSLNPDLNLQRYTPTVEKHASDRNSVDYAQIASGIDTRTTVMIKNIPNKFTQQMLRDYIDVTNKGTYDFLYLRIDFVNKCNVGYAFINFIEPQSIITFGKARVGTQWNVFHSEKICDISYANIQGKDRLIEKFRNSCVMDENPAYRPKIFVSHGPNRGMEEPFPAPNNARRKLRSIASAQQIGLFPPTASKC |
heterochromatin boundary formation negative regulation of DNA-templated transcription protein localization to euchromatin regulation of transcription by RNA polymerase II response to ecdysone | chromatin; nucleus | chromatin binding chromatin insulator sequence binding DNA binding DNA-binding transcription factor activity euchromatin binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding | Drosophila melanogaster | Chromatin regulator Chromosome DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MSASKEGKEK | MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA | heterochromatin boundary formation negative regulation of DNA-templated transcription protein localization to euchromatin regulation of transcription by RNA polymerase II response to ecdysone chromatin; nucleus chromatin binding chromatin insulator sequence binding DNA binding DNA-binding transcription factor activity euchromatin binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding Drosophila melanogaster Chromatin regulator Chromosome DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger MSASKEGKEK MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA |
DNA repair male germ-line stem cell population maintenance negative regulation of peptidoglycan recognition protein signaling pathway protein localization to chromatin somatic stem cell population maintenance | chromosome; euchromatin; nucleosome; nucleus; polytene chromosome; polytene chromosome chromocenter; site of double-strand break | DNA binding protein heterodimerization activity protein-containing complex binding structural constituent of chromatin | Drosophila melanogaster | Acetylation Chromosome Developmental protein DNA damage DNA repair DNA-binding Isopeptide bond Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation | MAGGKAGKDS | MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKEETVQDPQRKGNVILSQAY | DNA repair male germ-line stem cell population maintenance negative regulation of peptidoglycan recognition protein signaling pathway protein localization to chromatin somatic stem cell population maintenance chromosome; euchromatin; nucleosome; nucleus; polytene chromosome; polytene chromosome chromocenter; site of double-strand break DNA binding protein heterodimerization activity protein-containing complex binding structural constituent of chromatin Drosophila melanogaster Acetylation Chromosome Developmental protein DNA damage DNA repair DNA-binding Isopeptide bond Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation MAGGKAGKDS MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKEETVQDPQRKGNVILSQAY |
mast cell degranulation negative regulation of voltage-gated potassium channel activity negative regulation of voltage-gated sodium channel activity neuropeptide signaling pathway positive regulation of behavioral fear response positive regulation of peptide hormone secretion positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of respiratory gaseous exchange psychomotor behavior response to external biotic stimulus social behavior | extracellular space; neuron projection; secretory granule lumen | neuropeptide hormone activity | Canis lupus familiaris | Amidation Cell projection Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Mast cell degranulation Reference proteome Secreted Signal | MRGRELPLVL | MRGRELPLVLLALVLCQAPRGPAAPVPGGQGTVLDKMYPRGNHWAVGHLMGKKSTRESPYVYEEGSLKQQLQGYIRWEEAARNLLSLMEAKGTRSHQTPQREPLGIRQSAWDYQDDSNFKVIGPTREVGGLSASGSQPEGRNPPRN | mast cell degranulation negative regulation of voltage-gated potassium channel activity negative regulation of voltage-gated sodium channel activity neuropeptide signaling pathway positive regulation of behavioral fear response positive regulation of peptide hormone secretion positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of respiratory gaseous exchange psychomotor behavior response to external biotic stimulus social behavior extracellular space; neuron projection; secretory granule lumen neuropeptide hormone activity Canis lupus familiaris Amidation Cell projection Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Mast cell degranulation Reference proteome Secreted Signal MRGRELPLVL MRGRELPLVLLALVLCQAPRGPAAPVPGGQGTVLDKMYPRGNHWAVGHLMGKKSTRESPYVYEEGSLKQQLQGYIRWEEAARNLLSLMEAKGTRSHQTPQREPLGIRQSAWDYQDDSNFKVIGPTREVGGLSASGSQPEGRNPPRN |
animal organ development cellular response to insulin stimulus growth hormone receptor signaling pathway negative regulation of apoptotic process negative regulation of gene expression oviduct epithelium development positive regulation of gene expression positive regulation of growth positive regulation of multicellular organism growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein regulation of defense response to virus by host response to food response to nutrient levels | extracellular space; nucleus; plasma membrane; secretory granule; trans-Golgi network | cysteine-type endopeptidase activity involved in apoptotic process growth factor activity growth hormone receptor binding hormone activity metal ion binding | Gallus gallus | Disulfide bond Hormone Metal-binding Reference proteome Secreted Signal Zinc | MAPGSWFSPL | MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI | animal organ development cellular response to insulin stimulus growth hormone receptor signaling pathway negative regulation of apoptotic process negative regulation of gene expression oviduct epithelium development positive regulation of gene expression positive regulation of growth positive regulation of multicellular organism growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein regulation of defense response to virus by host response to food response to nutrient levels extracellular space; nucleus; plasma membrane; secretory granule; trans-Golgi network cysteine-type endopeptidase activity involved in apoptotic process growth factor activity growth hormone receptor binding hormone activity metal ion binding Gallus gallus Disulfide bond Hormone Metal-binding Reference proteome Secreted Signal Zinc MAPGSWFSPL MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI |
cellular response to cAMP cellular response to glucocorticoid stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to type II interferon response to bacterium response to cytokine response to lipopolysaccharide response to peptide hormone response to vitamin B6 | extracellular region; extracellular space | serine-type endopeptidase inhibitor activity | Rattus norvegicus | Glycoprotein Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MTRLVTLELL | MTRLVTLELLMAGIGSALLCFPDCILGEDTLFHEDQDKGTQLDSLTLASINTDFAFSLYKKLALRNPDKNVVFSPLSISAALAVVSLGAKGNSMEEILEGLKFNLTETPETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQAEAFTADFQQSREAKKLINDYVSKQTQGKIQGLITNLAKKTSMVLVNYIYFKGKWKVPFDPRDTFQSEFYSGKRRPVKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFILPDQGKMQQVEASLQPETLRRWKDSLRPSMIDELYLPKFSISADYNLEDVLPELGIKEVFSTQADLSGITGDKDLMVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLDPLIIAFDRPFLMIISDTETAIAPFLAKIFNPK | cellular response to cAMP cellular response to glucocorticoid stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to type II interferon response to bacterium response to cytokine response to lipopolysaccharide response to peptide hormone response to vitamin B6 extracellular region; extracellular space serine-type endopeptidase inhibitor activity Rattus norvegicus Glycoprotein Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal MTRLVTLELL MTRLVTLELLMAGIGSALLCFPDCILGEDTLFHEDQDKGTQLDSLTLASINTDFAFSLYKKLALRNPDKNVVFSPLSISAALAVVSLGAKGNSMEEILEGLKFNLTETPETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQAEAFTADFQQSREAKKLINDYVSKQTQGKIQGLITNLAKKTSMVLVNYIYFKGKWKVPFDPRDTFQSEFYSGKRRPVKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFILPDQGKMQQVEASLQPETLRRWKDSLRPSMIDELYLPKFSISADYNLEDVLPELGIKEVFSTQADLSGITGDKDLMVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLDPLIIAFDRPFLMIISDTETAIAPFLAKIFNPK |
canalicular bile acid transport gap junction-mediated intercellular transport lens development in camera-type eye positive regulation of cell adhesion protein homotetramerization visual perception water transport | apical plasma membrane; endoplasmic reticulum; gap junction; intracellular canaliculus; membrane; plasma membrane | calmodulin binding structural constituent of eye lens water channel activity | Rattus norvegicus | Cell junction Cell membrane Eye lens protein Gap junction Lipoprotein Membrane Phosphoprotein Reference proteome Repeat Transmembrane Transmembrane helix Transport | ELRSASFWRA | ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL | canalicular bile acid transport gap junction-mediated intercellular transport lens development in camera-type eye positive regulation of cell adhesion protein homotetramerization visual perception water transport apical plasma membrane; endoplasmic reticulum; gap junction; intracellular canaliculus; membrane; plasma membrane calmodulin binding structural constituent of eye lens water channel activity Rattus norvegicus Cell junction Cell membrane Eye lens protein Gap junction Lipoprotein Membrane Phosphoprotein Reference proteome Repeat Transmembrane Transmembrane helix Transport ELRSASFWRA ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL |
mRNA splicing, via spliceosome | nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U4/U6 x U5 tri-snRNP complex | DNA binding identical protein binding RNA binding U1 snRNA binding U1 snRNP binding | Homo sapiens | 3D-structure Acetylation Direct protein sequencing Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome | MAVPETRPNH | MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK | mRNA splicing, via spliceosome nucleoplasm; nucleus; spliceosomal complex; U1 snRNP; U4/U6 x U5 tri-snRNP complex DNA binding identical protein binding RNA binding U1 snRNA binding U1 snRNP binding Homo sapiens 3D-structure Acetylation Direct protein sequencing Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome MAVPETRPNH MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK |
anterior/posterior pattern specification apoptotic process involved in morphogenesis axonogenesis involved in innervation cell fate specification midbrain development midbrain-hindbrain boundary development midbrain-hindbrain boundary morphogenesis neuron differentiation regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Danio rerio | Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MDENEQSARD | MDENEQSARDVEQRGASDESNSAIRPLLQAPGNLQLPHRITNFFIDNILRPDFGRKKEANITRYEDNHGARENHNPTGPSTGQVGSTVPAEEASTTHTSSGGKEAEIESEEPLKPRGENVDQCLGSESDSSQSNSNGQTGQGMLWPAWVYCTRYSDRPSSGPRSRKPKKKAASKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKKASGVKNGLAIHLMAQGLYNHSTTSKEDKSDSD | anterior/posterior pattern specification apoptotic process involved in morphogenesis axonogenesis involved in innervation cell fate specification midbrain development midbrain-hindbrain boundary development midbrain-hindbrain boundary morphogenesis neuron differentiation regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Danio rerio Developmental protein DNA-binding Homeobox Nucleus Reference proteome MDENEQSARD MDENEQSARDVEQRGASDESNSAIRPLLQAPGNLQLPHRITNFFIDNILRPDFGRKKEANITRYEDNHGARENHNPTGPSTGQVGSTVPAEEASTTHTSSGGKEAEIESEEPLKPRGENVDQCLGSESDSSQSNSNGQTGQGMLWPAWVYCTRYSDRPSSGPRSRKPKKKAASKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKKASGVKNGLAIHLMAQGLYNHSTTSKEDKSDSD |
anterior/posterior pattern specification embryonic organ development embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II stem cell differentiation | cell junction; chromatin; nucleoplasm | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MVMSSYMVNS | MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL | anterior/posterior pattern specification embryonic organ development embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II stem cell differentiation cell junction; chromatin; nucleoplasm DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MVMSSYMVNS MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL |
anterior/posterior pattern specification cartilage development embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II | chromatin; nucleoplasm | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific HMG box domain binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MIMSSYLMDS | MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL | anterior/posterior pattern specification cartilage development embryonic skeletal system morphogenesis positive regulation of transcription by RNA polymerase II chromatin; nucleoplasm DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific HMG box domain binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MIMSSYLMDS MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL |
abducens nerve formation anatomical structure formation involved in morphogenesis anatomical structure morphogenesis anterior/posterior pattern specification artery development artery morphogenesis cellular response to ethanol cellular response to retinoic acid central nervous system neuron differentiation cochlea development cochlea morphogenesis cognition embryonic neurocranium morphogenesis facial nerve structural organization facial nucleus development hindbrain development inner ear development inner ear morphogenesis motor neuron axon guidance nervous system development neuromuscular process optokinetic behavior outer ear morphogenesis positive regulation of transcription by RNA polymerase II regulation of behavior regulation of transcription by RNA polymerase II rhombomere 3 development rhombomere 4 development rhombomere 5 development semicircular canal formation sensory perception of sound | nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Alternative splicing Developmental protein Direct protein sequencing DNA-binding Glycoprotein Homeobox Nucleus Reference proteome Transcription Transcription regulation | MNSFLEYPIL | MNSFLEYPILGSGDSGTCSARAYPSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHHHHHPQTATYQTSGNLGISYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSTPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEQQTLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKTEESSEKSSPSPSAPSPASSTSDTLTTSH | abducens nerve formation anatomical structure formation involved in morphogenesis anatomical structure morphogenesis anterior/posterior pattern specification artery development artery morphogenesis cellular response to ethanol cellular response to retinoic acid central nervous system neuron differentiation cochlea development cochlea morphogenesis cognition embryonic neurocranium morphogenesis facial nerve structural organization facial nucleus development hindbrain development inner ear development inner ear morphogenesis motor neuron axon guidance nervous system development neuromuscular process optokinetic behavior outer ear morphogenesis positive regulation of transcription by RNA polymerase II regulation of behavior regulation of transcription by RNA polymerase II rhombomere 3 development rhombomere 4 development rhombomere 5 development semicircular canal formation sensory perception of sound nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Mus musculus Alternative splicing Developmental protein Direct protein sequencing DNA-binding Glycoprotein Homeobox Nucleus Reference proteome Transcription Transcription regulation MNSFLEYPIL MNSFLEYPILGSGDSGTCSARAYPSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHHHHHPQTATYQTSGNLGISYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSTPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEQQTLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKTEESSEKSSPSPSAPSPASSTSDTLTTSH |
anterior/posterior pattern specification embryonic skeletal system morphogenesis myeloid cell differentiation positive regulation of branching involved in ureteric bud morphogenesis positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | cytosol; nuclear body; nucleoplasm; nucleus | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSSLYYANAL | MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGAMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEAEEEEEE | anterior/posterior pattern specification embryonic skeletal system morphogenesis myeloid cell differentiation positive regulation of branching involved in ureteric bud morphogenesis positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cytosol; nuclear body; nucleoplasm; nucleus DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Mus musculus Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MSSLYYANAL MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGAMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEAEEEEEE |
anterior/posterior pattern specification negative regulation of transcription by RNA polymerase II neuron differentiation regulation of transcription by RNA polymerase II skeletal system morphogenesis | microtubule cytoskeleton; nucleoplasm; nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSSYFVNPLF | MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD | anterior/posterior pattern specification negative regulation of transcription by RNA polymerase II neuron differentiation regulation of transcription by RNA polymerase II skeletal system morphogenesis microtubule cytoskeleton; nucleoplasm; nucleus DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Mus musculus Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MSSYFVNPLF MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD |
angiogenesis anterior/posterior pattern specification cartilage development definitive hemopoiesis embryonic skeletal system morphogenesis face development glossopharyngeal nerve morphogenesis hematopoietic progenitor cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of neurogenesis regulation of transcription by RNA polymerase II rhombomere development thyroid gland development | nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MQKATYYDNT | MQKATYYDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAAPMGPNQHHGPCDPHPTYTDLSSHHAPPQGRIQEAPKLTHL | angiogenesis anterior/posterior pattern specification cartilage development definitive hemopoiesis embryonic skeletal system morphogenesis face development glossopharyngeal nerve morphogenesis hematopoietic progenitor cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of neurogenesis regulation of transcription by RNA polymerase II rhombomere development thyroid gland development nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Mus musculus Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MQKATYYDNT MQKATYYDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAAPMGPNQHHGPCDPHPTYTDLSSHHAPPQGRIQEAPKLTHL |
anterior/posterior pattern specification cartilage development cell-matrix adhesion DNA-templated transcription embryonic skeletal system morphogenesis glossopharyngeal nerve morphogenesis Notch signaling pathway positive regulation of gene expression positive regulation of neuron differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II thyroid gland development | aggresome; nuclear body; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Mus musculus | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MLFEQGQLTL | MLFEQGQLTLELPECTMQKAAYYENPGLFGGYGYSKATDTYGYSTPHQPYPPPAAANSLDSDYPSSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQQPPQPPPPPPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTISKQIFPWMKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYPAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVDSMAPTSGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL | anterior/posterior pattern specification cartilage development cell-matrix adhesion DNA-templated transcription embryonic skeletal system morphogenesis glossopharyngeal nerve morphogenesis Notch signaling pathway positive regulation of gene expression positive regulation of neuron differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II thyroid gland development aggresome; nuclear body; nucleoplasm; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Mus musculus Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MLFEQGQLTL MLFEQGQLTLELPECTMQKAAYYENPGLFGGYGYSKATDTYGYSTPHQPYPPPAAANSLDSDYPSSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQQPPQPPPPPPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTISKQIFPWMKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYPAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVDSMAPTSGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL |
de novo' IMP biosynthetic process | cytosol | 5-(carboxyamino)imidazole ribonucleotide synthase activity ATP binding metal ion binding phosphoribosylaminoimidazole carboxylase activity | Escherichia coli | 3D-structure ATP-binding Direct protein sequencing Ligase Nucleotide-binding Purine biosynthesis Reference proteome | MKQVCVLGNG | MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAQAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG | de novo' IMP biosynthetic process cytosol 5-(carboxyamino)imidazole ribonucleotide synthase activity ATP binding metal ion binding phosphoribosylaminoimidazole carboxylase activity Escherichia coli 3D-structure ATP-binding Direct protein sequencing Ligase Nucleotide-binding Purine biosynthesis Reference proteome MKQVCVLGNG MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAQAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG |
DNA damage response DNA repair | cytosol | DNA binding double-stranded DNA 3'-5' DNA exonuclease activity endonuclease activity exonuclease activity metal ion binding | Escherichia coli | 3D-structure DNA damage DNA repair Exonuclease Hydrolase Magnesium Metal-binding Nuclease Reference proteome | MKFVSFNING | MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDDMFPLEEVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFLPEEREWMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAECCVETGIDYEIRSMEKPSDHAPVWATFRR | DNA damage response DNA repair cytosol DNA binding double-stranded DNA 3'-5' DNA exonuclease activity endonuclease activity exonuclease activity metal ion binding Escherichia coli 3D-structure DNA damage DNA repair Exonuclease Hydrolase Magnesium Metal-binding Nuclease Reference proteome MKFVSFNING MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDDMFPLEEVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFLPEEREWMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAECCVETGIDYEIRSMEKPSDHAPVWATFRR |
cytoplasmic translational initiation negative regulation of cellular response to amino acid starvation regulation of translational initiation | cytosol; eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor complex | translation initiation factor activity | Saccharomyces cerevisiae | 3D-structure Cytoplasm Initiation factor Phosphoprotein Protein biosynthesis Reference proteome Translation regulation | MSIQAFVFCG | MSIQAFVFCGKGSNLAPFTQPDFPFQTQNKDSTAATSGDKLNELVNSALDSTVINEFMQHSTRLPKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIESGLTSFLSLRKQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESLQKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNLAMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNSFIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQQQQNPPTTDDDEDRNHDDDDDYKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQHSKPREPIGIFILPNETLFIRANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKCQISAHSNVKMSVLGTQANIGSRCRVAGSLLFPGVHLGDEVILENCIIGPMAKIGSKCKLSNCYIEGHYVVEPKNNFKGETLANVYLDEDEEDELIYDDSVIAGESEIAEETDSDDRSDEDSDDSEYTDEYEYEDDGLFER | cytoplasmic translational initiation negative regulation of cellular response to amino acid starvation regulation of translational initiation cytosol; eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor complex translation initiation factor activity Saccharomyces cerevisiae 3D-structure Cytoplasm Initiation factor Phosphoprotein Protein biosynthesis Reference proteome Translation regulation MSIQAFVFCG MSIQAFVFCGKGSNLAPFTQPDFPFQTQNKDSTAATSGDKLNELVNSALDSTVINEFMQHSTRLPKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIESGLTSFLSLRKQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESLQKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNLAMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNSFIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQQQQNPPTTDDDEDRNHDDDDDYKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQHSKPREPIGIFILPNETLFIRANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKCQISAHSNVKMSVLGTQANIGSRCRVAGSLLFPGVHLGDEVILENCIIGPMAKIGSKCKLSNCYIEGHYVVEPKNNFKGETLANVYLDEDEEDELIYDDSVIAGESEIAEETDSDDRSDEDSDDSEYTDEYEYEDDGLFER |
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