source_doi stringlengths 13 57 | source_mag_paper_id int64 490k 157M | source_abstract stringlengths 8 10.7k | target_doi stringlengths 14 27 | target_summary stringlengths 42 889 |
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10.1111/j.1502-3885.2008.00051.x | 100,593,413 | Optical dating measures the time that has elapsed since mineral grains were exposed to daylight. The technique is ideal for sediments in which all the grains were exposed to sufficient daylight at deposition to reset the optically stimulated luminescence (OSL) signal. However, in many environments the exposure of indiv... | 10.1038/s43586-021-00068-5 | This work presents a review of the benefits and disadvantages of dose measurements using single grains |
10.1038/s41598-021-87056-7 | 83,996,639 | Abstract The interplay between ferromagnetism and topological properties of electronic band structures leads to a precise quantization of Hall resistance without any external magnetic field. This so-called quantum anomalous Hall effect (QAHE) is born out of topological correlations, and is oblivious of low-sample quali... | 10.1038/s41928-023-00930-2 | This paper developed a cryogenic memory system using topological properties of materials |
10.1063/1.343077 | 66,513,588 | A proposal vortex transitional nondestructive read-out Josephson memory cell is successfully fabricated and tested. The memory cell consists of two superconducting loops in which a single flux quantum is stored and a two-junction interferometer gate as a sense gate. The memory cell employs vortex transitions in the sup... | 10.1038/s41928-023-00930-2 | This paper proposed and demonstrated a superconducting memory for cryogenic applications |
10.1063/1.4723576 | 20,377,206 | We develop a fast magnetic Josephson junction (MJJ)—a superconducting ferromagnetic device for a scalable high-density cryogenic memory compatible in speed and fabrication with energy-efficient single flux quantum (SFQ) circuits. We present experimental results for superconductor-insulator-ferromagnet-superconductor (S... | 10.1038/s41928-023-00930-2 | This paper incorporated an additional superconducting layer to the MJJ structure to make the switching speed compatible with SFQ circuits |
10.1038/s41598-022-18024-y | 129,949,058 | Abstract The modeling of extended microcircuits is emerging as an effective tool to simulate the neurophysiological correlates of brain activity and to investigate brain dysfunctions. However, for specific networks, a realistic modeling approach based on the combination of available physiological, morphological and ana... | 10.1038/s43588-023-00421-6 | This paper reports the development of a model of mouse CA1 hippocampus. |
10.1073/pnas.94.2.719 | 41,760,412 | Although signaling between neurons is central to the functioning of the brain, we still do not understand how the code used in signaling depends on the properties of synaptic transmission. Theoretical analysis combined with patch clamp recordings from pairs of neocortical pyramidal neurons revealed that the rate of syn... | 10.1038/s43588-023-00421-6 | This paper describes the modeling of synapses with short plasticity dynamics. |
10.1126/scitranslmed.abp8982 | 138,367,407 | Precise estimates of epileptogenic zone networks (EZNs) are crucial for planning intervention strategies to treat drug-resistant focal epilepsy. Here, we present the virtual epileptic patient (VEP), a workflow that uses personalized brain models and machine learning methods to estimate EZNs and to aid surgical strategi... | 10.1038/s43588-023-00421-6 | This paper reports the prediction of surgical performance by a model based on The Virtual Brain. |
10.1126/science.1058847 | 125,176,435 | We present experimental scattering data at microwave frequencies on a structured metamaterial that exhibits a frequency band where the effective index of refraction ( n ) is negative. The material consists of a two-dimensional array of repeated unit cells of copper strips and split ring resonators on interlocking strip... | 10.1038/s42254-018-0018-y | This experimental paper on negative refractive indices at microwave frequencies is a catalyser for the metamaterial field |
10.1177/1745691618774270 | 83,271,804 | Belief in conspiracy theories—such as that the 9/11 terrorist attacks were an inside job or that the pharmaceutical industry deliberately spreads diseases—is a widespread and culturally universal phenomenon. Why do so many people around the globe believe conspiracy theories, and why are they so influential? Previous re... | 10.1038/s44159-022-00133-0 | This article argues that conspiracy beliefs are part of an evolved psychological mechanism aimed at detecting hostile groups |
10.1111/bjop.12018 | 83,271,736 | The current studies explored the social consequences of exposure to conspiracy theories. In Study 1, participants were exposed to a range of conspiracy theories concerning government involvement in significant events such as the death of Diana, Princess of Wales. Results revealed that exposure to information supporting... | 10.1038/s44159-022-00133-0 | This article is one of the first experimental demonstrations of the effects of conspiracy theories on people’s attitudes and intentions in important societal domains |
10.1177/0963721417718261 | 83,438,778 | What psychological factors drive the popularity of conspiracy theories, which explain important events as secret plots by powerful and malevolent groups? What are the psychological consequences of adopting these theories? We review the current research and find that it answers the first of these questions more thorough... | 10.1038/s44159-022-00133-0 | This article articulates a framework for the motivational underpinnings of conspiracy beliefs |
10.1002/acp.2995 | 107,222,487 | Summary People who believe in the paranormal have been found to be particularly susceptible to the conjunction fallacy. The present research examines whether the same is true of people who endorse conspiracy theories. Two studies examined the association between conspiracist ideation and the number of conjunction viola... | 10.1038/s44159-022-00133-0 | This study finds an association between a cognitive bias (the conjunction fallacy) and conspiracy beliefs |
10.1111/bjso.12494 | 130,678,124 | The present research empirically examines how different types of coping strategies are associated with belief in conspiracy theories. Conspiracy beliefs have been linked to the frustration of basic needs and seem to increase during major world events that evoke stress. Thus, we hypothesized that they may serve as a psy... | 10.1038/s44159-022-00133-0 | This study demonstrates that people are drawn to conspiracy theories when they display maladaptive coping strategies |
10.1177/01461672211060965 | 133,373,659 | Research suggests that conspiracy beliefs are adopted because they promise to reduce anxiety, uncertainty, and threat. However, little research has investigated whether conspiracy beliefs actually fulfill these promises. We conducted two longitudinal studies ( N Study 1 = 405, N Study 2 = 1,012) to examine how conspira... | 10.1038/s44159-022-00133-0 | This rare longitudinal investigation of conspiracy beliefs finds that rather than satisfying psychological motives, conspiracy beliefs might only further frustrate them |
10.1177/1948550615616170 | 83,271,735 | Across three studies, we examined the role of self-evaluation in predicting conspiracy beliefs. Previous research linked the endorsement of conspiracy theories to low self-esteem. We propose that conspiracy theories should rather be appealing to individuals with exaggerated feelings of self-love, such as narcissists, d... | 10.1038/s44159-022-00133-0 | This study finds that narcissism plays a part in predicting conspiracy beliefs |
10.1057/s41599-019-0279-9 | 83,516,029 | Abstract The spread of online misinformation poses serious challenges to societies worldwide. In a novel attempt to address this issue, we designed a psychological intervention in the form of an online browser game. In the game, players take on the role of a fake news producer and learn to master six documented techniq... | 10.1038/s44159-022-00133-0 | This article outlines the use of an online game to inoculate people against misinformation |
10.1073/pnas.2120584119 | 128,872,919 | Understanding and communicating the environmental impacts of food products is key to enabling transitions to environmentally sustainable food systems [El Bilali and Allahyari, Inf. Process. Agric. 5, 456–464 (2018)]. While previous analyses compared the impacts of food commodities such as fruits, wheat, and beef [Poore... | 10.1038/s43016-022-00645-1 | An article highlighting the eutrophication risk associated with the production of different food products, including dairy. |
10.1002/agr.21790 | 139,722,918 | Abstract This study examined monthly retail‐level price premiums for grass‐fed beef (relative to conventional grain‐fed beef) in the United States from 2014 through 2021. We found that premiums were heterogeneous, with premium cuts, such as sirloin steak, tenderloin, ribeye and filet mignon enjoying the highest premium... | 10.1038/s43016-022-00645-1 | An article outlining the magnitude and reasons behind consumer premiums for grass-fed milk. |
10.3390/w12041197 | 109,064,014 | Pollution of ground-and surface waters with nitrates from agricultural sources poses a risk to drinking water quality and has negative impacts on the environment. At the national scale, the gross nitrogen budget (GNB) is accepted as an indicator of pollution caused by nitrates. There is, however, little common EU-wide ... | 10.1038/s43016-022-00645-1 | An article outlining the case for using a nitrogen surplus to guide policy to improve water quality. |
10.1126/science.aad4998 | 20,857,614 | Better living through water-splitting Chemists have known how to use electricity to split water into hydrogen and oxygen for more than 200 years. Nonetheless, because the electrochemical route is inefficient, most of the hydrogen made nowadays comes from natural gas. Seh et al. review recent progress in electrocatalyst... | 10.1038/s41929-019-0306-7 | This review describes the interplay between experiment and theory in electrocatalysis for a variety of reactions, as well as introducing intermediate binding strength and scaling relations as frameworks for understanding catalytic activity |
10.1002/cssc.201600394 | 103,649,595 | Abstract We introduce a gross‐margin model to evaluate the technoeconomic feasibility of producing different C 1 –C 2 chemicals such as carbon monoxide, formic acid, methanol, methane, ethanol, and ethylene through the electroreduction of CO 2 . Key performance benchmarks including the maximum operating cell potential ... | 10.1038/s41929-019-0306-7 | This work presents a thorough technoeconomic analysis of CO 2 reduction at the device level, explicitly describing how to treat capital costs, catalyst durability and electricity prices. |
10.1126/science.aas9100 | 20,663,588 | A very basic pathway from CO 2 to ethylene Ethylene is an important commodity chemical for plastics. It is considered a tractable target for synthesizing renewably from carbon dioxide (CO 2 ). The challenge is that the performance of the copper electrocatalysts used for this conversion under the required basic reaction... | 10.1038/s41929-019-0306-7 | This work illustrates how the design of an electrolyser system can dramatically improve performance, here, particularly for the synthesis of ethylene. |
10.1073/pnas.1711493114 | 104,405,102 | Direct conversion of carbon dioxide to multicarbon products remains as a grand challenge in electrochemical CO 2 reduction. Various forms of oxidized copper have been demonstrated as electrocatalysts that still require large overpotentials. Here, we show that an ensemble of Cu nanoparticles (NPs) enables selective form... | 10.1038/s41929-019-0306-7 | This work demonstrates the importance of Cu structural dynamics in electrolytic conditions that produce multi -carbon products. |
10.1002/evl3.6 | 81,033,696 | Abstract Domesticated grain crops evolved from wild plants under human cultivation, losing natural dispersal mechanisms to become dependent upon humans, and showing changes in a suite of other traits, including increasing seed size. There is tendency for seed enlargement during domestication to be viewed as the result ... | 10.1038/s42003-021-02467-6 | The authors conclude that seed enlargement is driven by a combined effect of natural and artificial selection |
10.1146/annurev-ento-010814-020601 | 62,561,346 | Crop domestication is the process of artificially selecting plants to increase their suitability to human requirements: taste, yield, storage, and cultivation practices. There is increasing evidence that crop domestication can profoundly alter interactions among plants, herbivores, and their natural enemies. Overall, l... | 10.1038/s42003-021-02467-6 | The authors reflect on the impact of plant domestication at an ecosystem level |
10.1038/s41396-017-0028-2 | 83,404,965 | Abstract Plant seeds are home to diverse microbial communities whose composition is determined by plant genotype, environment, and management practices. Plant domestication is now recognized as an important driver of plant-associated microbial diversity. To what extent and how domestication affects seed microbiomes is ... | 10.1038/s42003-021-02467-6 | The authors reflect on the importance of seed microbiomes for agriculture |
10.1038/s41467-020-18560-z | 103,837,761 | Abstract Unraveling the drivers controlling community assembly is a central issue in ecology. Although it is generally accepted that selection, dispersal, diversification and drift are major community assembly processes, defining their relative importance is very challenging. Here, we present a framework to quantitativ... | 10.1038/s42003-021-02467-6 | The authors developed a quantitative framework that can be used to identify ecological processes driving microbiome assembly |
10.1111/micc.12536 | 38,102,868 | Abstract Objective Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angin... | 10.1038/s44161-022-00045-5 | Study providing evidence in support of microvascular disease being a whole-body disease, as it showed that CMD was associated with retinal microvascular changes that were different from those in CAD in participants of the Australian Heart Eye Study |
10.1111/j.1552-6569.2001.tb00025.x | 19,058,394 | ABSTRACT Objective . To test the hypothesis that syndrome X is a systemic vascular disorder, the authors studied 40 patients with this diagnosis using technetium‐99m hexamethylpropylene amine oxime and single photon emission computed tomography (SPECT) brain images. Twenty‐three of 25 cases with definite myocardial per... | 10.1038/s44161-022-00045-5 | Case–control study describing the coexistence of MVD in the heart and brain in patients with cardiac syndrome X and myocardial perfusion defects who had an increased risk of brain hypoperfusion lesions |
10.1143/jjap.30.l215 | 27,677,372 | An electrically erasable memory device is fabricated using a conducting polymer and solid polymer electrolyte. The conductivity of the memory channel consisting of the conducting polymer is controlled by electrochemical doping through the counter (writing) electrode. The channel conductivity was varied by the number of... | 10.1038/s41928-018-0103-3 | This article reports the first demonstration of hybrid electronic/ionic switching in a conducting-polymer-based non-volatile memory device. |
10.1126/sciadv.1501326 | 123,156,631 | Emulation of biological synapses is an important step toward construction of large-scale brain-inspired electronics. Despite remarkable progress in emulating synaptic functions, current synaptic devices still consume energy that is orders of magnitude greater than do biological synapses (~10 fJ per synaptic event). Red... | 10.1038/s41928-018-0103-3 | This article shows an artificial synapse that switches at femtojoule energy consumption |
10.1152/ajpcell.00269.2001 | 41,742,952 | The tensegrity hypothesis holds that the cytoskeleton is a structure whose shape is stabilized predominantly by the tensile stresses borne by filamentous structures. Accordingly, cell stiffness must increase in proportion with the level of the tensile stress, which is called the prestress. Here we have tested that pred... | 10.1038/s42254-020-0184-6 | Description of the general concept underlying MSM, applied here to the inference of internal stress in a single cell |
10.1126/science.6987736 | 20,376,312 | When tissue cells are cultured on very thin sheets of cross-linked silicone fluid, the traction forces the cells exert are made visible as elastic distortion and wrinkling of this substratum. Around explants this pattern of wrinkling closely resembles the "center effects" long observed in plasma clots and traditionally... | 10.1038/s42254-020-0184-6 | First qualitative implementation of TFM, based on the observation that cells are able to wrinkle thin polymer substrates |
10.1152/ajpcell.00270.2001 | 62,668,702 | Adherent cells exert tractions on their surroundings. These tractions can be measured by observing the displacements of beads embedded on a flexible gel substrate on which the cells are cultured. This paper presents an exact solution to the problem of computing the traction field from the observed displacement field. T... | 10.1038/s42254-020-0184-6 | This paper formulates Fourier 2D TFM, resulting in the speeding up of traction calculations by orders of magnitude |
10.1073/pnas.0235407100 | 62,197,824 | We describe an approach to manipulate and measure mechanical interactions between cells and their underlying substrates by using microfabricated arrays of elastomeric, microneedle-like posts. By controlling the geometry of the posts, we varied the compliance of the substrate while holding other surface properties const... | 10.1038/s42254-020-0184-6 | This paper pioneered the use of micropillar arrays for force quantification |
10.1073/pnas.1213301109 | 104,378,858 | One-cell-thick monolayers are the simplest tissues in multicellular organisms, yet they fulfill critical roles in development and normal physiology. In early development, embryonic morphogenesis results largely from monolayer rearrangement and deformation due to internally generated forces. Later, monolayers act as phy... | 10.1038/s42254-020-0184-6 | This paper shows the first implementation of the suspended-monolayer technique |
10.1152/ajplegacy.1964.207.1.173 | 39,243,295 | Pressure within the microvascular bed of the frog mesentery has been recorded continuously with micropressure transducers which have tip diameters ranging between 0.5–5 µ. The mean values of pressure are in the range of those previously reported. The waveform of the pressure pulses in arterioles and metarterioles close... | 10.1038/s42254-020-0184-6 | Implementation of servo-null systems and their application to measure pulsatile pressure in a capillary |
10.1083/jcb.149.2.471 | 40,150,622 | The molecular and cellular bases of cell shape change and movement during morphogenesis and wound healing are of intense interest and are only beginning to be understood. Here, we investigate the forces responsible for morphogenesis during dorsal closure with three approaches. First, we use real-time and time-lapsed la... | 10.1038/s42254-020-0184-6 | This paper is a pioneering work in the implementation of laser ablation as a tissue-stress-inference method |
10.1038/ncomms12092 | 83,435,998 | Abstract Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies have identified >150 loci associated with CAD and myocardial infarction susceptibility in humans. A majority of these variant... | 10.1038/s44161-022-00053-5 | Application of genomic methods to identify causative CAD genetic variants |
10.1073/pnas.1810141115 | 62,611,647 | We explore the risk that self-reinforcing feedbacks could push the Earth System toward a planetary threshold that, if crossed, could prevent stabilization of the climate at intermediate temperature rises and cause continued warming on a “Hothouse Earth” pathway even as human emissions are reduced. Crossing the threshol... | 10.1038/s41893-018-0194-x | This paper describes the high risk of a ‘Hothouse Earth’ future if the planetary boundaries are transgressed and an Earth system threshold is crossed |
10.1126/science.1217255 | 61,799,616 | The United Nations conference in Rio de Janeiro in June is an important opportunity to improve the institutional framework for sustainable development. | 10.1038/s41893-018-0194-x | This paper delivers important insights into how to understand the societal and political challenges associated with planetary boundaries and suggests viable global institutional architectures necessary for politics and governance to span all planetary boundaries while avoiding undesirable environmental shifts |
10.1257/aer.102.1.131 | 83,341,457 | This paper introduces endogenous and directed technical change in a growth model with environmental constraints. The final good is produced from “dirty” and “clean” inputs. We show that: (i) when inputs are sufficiently substitutable, sustainable growth can be achieved with temporary taxes/subsidies that redirect innov... | 10.1038/s41893-018-0194-x | This paper analyses how policies should be designed to simultaneously strengthen innovation in technologies that facilitate sustainable growth and weaken the development of technologies that threaten it |
10.1002/iub.354 | 83,310,536 | Abstract The Kennedy Pathway. See The Kennedy Pathway–De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine by Federica Gibellini and Terry K. Smith, pp. 414–428. | 10.1038/s42255-023-00767-1 | A Review article that summarizes properties and functions of the enzymes in the biosynthetic steps of the Kennedy pathway. |
10.1093/brain/awz291 | 45,457,592 | Abstract CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Phosphatidylethanolamine is one of the most abundant membrane lipids and is particularly enriched in the brain. We identified five individual... | 10.1038/s42255-023-00767-1 | A paper reporting that human patients with PCYT2 mutations exhibit a complex disorder that includes muscle weakness. |
10.1038/s41598-017-15191-1 | 80,552,012 | Abstract Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance. Loss of the PtdSer receptor Mertk is associated with apoptotic corpse accumulation in the testes and de... | 10.1038/s42255-023-00745-7 | This paper contains the RNA-seq data set from which our original observations on insulin in the eye began. |
10.1152/ajpendo.00507.2002 | 122,203,599 | Insulin receptor (IR) signaling cascades have been studied in many tissues, but retinal insulin action has received little attention. Retinal IR signaling and activity were investigated in vivo in rats that were freely fed, fasted, or injected with insulin by phosphotyrosine immunoblotting and by measuring kinase activ... | 10.1038/s42255-023-00745-7 | This paper shows that insulin injected into the portal vein of rats does not affect insulin signalling in the retina. |
10.1038/s41416-020-01122-x | 41,741,568 | Abstract Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers. However, the growing number of these complex biomarkers tends to increase the cost and time for decision-making in routine daily oncology practice; furthermore, biomarkers often require tumour tissue on top of routine diagno... | 10.1038/s43018-022-00417-7 | A review article describing deep learning applications to cancer histopathology. |
10.1038/s41598-019-41953-0 | 60,151,775 | Abstract Negative emissions technologies offer an important tool to limit the global warming to <2 °C. Biochar is one of only a few such technologies, and the one at highest technology readiness level. Here we show that potassium as a low-concentration additive in biochar production can increase biochar’s carbon seq... | 10.1038/s43247-022-00394-w | Biomass doping with pure minerals can increase the carbon sequestration potential per biomass input |
10.1126/science.aaa1668 | 104,401,651 | The difference is found at the margins The terrestrial biosphere absorbs about a quarter of all anthropogenic carbon dioxide emissions, but the amount that they take up varies from year to year. Why? Combining models and observations, Ahlström et al. found that marginal ecosystems—semiarid savannas and low-latitude shr... | 10.1038/s43017-021-00144-0 | Highlights the critical role of drylands in the global carbon budget by demonstrating that semi-arid ecosystems dominate the inter-annual variability and the increasing trend of global terrestrial carbon sink |
10.1002/grl.50563 | 40,279,668 | Satellite observations reveal a greening of the globe over recent decades. The role in this greening of the “CO 2 fertilization” effect—the enhancement of photosynthesis due to rising CO 2 levels—is yet to be established. The direct CO 2 effect on vegetation should be most clearly expressed in warm, arid environments w... | 10.1038/s43017-021-00144-0 | Reveals widespread greening in global arid regions despite warming, and provides quantitative theoretical evidence linking this greening pattern with elevated CO 2 |
10.5194/gmd-9-175-2016 | 83,100,268 | Abstract. To sustain growing food demand and increasing standard of living, global water use increased by nearly 6 times during the last 100 years, and continues to grow. As water demands get closer and closer to the water availability in many regions, each drop of water becomes increasingly valuable and water must be ... | 10.1038/s43017-021-00144-0 | Provides an ensemble model projection of significant increases in the twenty-first century’s water demand by major water-use sectors under envisaged population growth and socio-economic developments |
10.1366/000370206779321463 | 81,923,737 | We compare and contrast two Raman collection geometries, backscattering and transmission, to identify their potential for monitoring the bulk chemical composition of turbid media. The experiments performed on pharmaceutical tablets confirm the expected strong bias of the backscattering Raman collection towards surface ... | 10.1038/s43586-021-00019-0 | This paper is the first demonstration of TRS volumetric sensing capability |
10.1002/jrs.5875 | 74,128,048 | Abstract Here we demonstrate the simultaneous recovery of multiplexed physical information of surface‐enhanced Raman scattering (SERS) nanoparticles (pH and depth) using deep Raman spectroscopy. As has been shown previously and in accordance with theory, inelastically scattered photons arising from spectral peaks that ... | 10.1038/s43586-021-00019-0 | This paper is the first conceptual demonstration of SESORS to measure pH |
10.1366/13-07376 | 124,614,432 | Here we present, for the first time, an extension of spatially offset Raman spectroscopy to thin (tens of micrometers thick), highly turbid stratified media such as those encountered in paintings. The method permits the non-destructive interrogation of painted layers in situations where conventional Raman microscopy is... | 10.1038/s43586-021-00019-0 | This paper is the first conceptual demonstration of micro-SORS, a high-resolution variant of spatially offset Raman spectroscopy |
10.1039/c5fd00154d | 68,409,291 | Here we demonstrate for the first time the viability of characterising non-invasively the subsurface temperature of SERS nanoparticles embedded within biological tissues using spatially offset Raman spectroscopy (SORS). The proposed analytical method (T-SESORS) is applicable in general to diffusely scattering (turbid) ... | 10.1038/s43586-021-00019-0 | This paper is the first conceptual demonstration of T-SESORS, a variant of SESORS and TRS |
10.1002/adfm.201400793 | 40,880,764 | Here, it is shown that graphene oxide (GO) can be utilized as both a cell‐adhesion substrate and a growth factor protein‐delivery carrier for the chondrogenic differentiation of adult stem cells. Conventionally, chondrogenic differentiation of stem cells is achieved by culturing cells in pellets and adding the protein ... | 10.1038/s42004-019-0254-9 | “Graphene oxide enhanced the chondrogenic differentiation by acting cell adhesion substrate and protein delivery carrier” |
10.1002/smll.201500841 | 125,177,396 | Surface‐induced blood clotting is one of the major problems associated with the long‐term use of blood‐contacting biomedical devices. Central to this obstructive blood clotting is the adsorption of plasma proteins following the interactions between blood and material surface. Of all proteins circulating in the blood pl... | 10.1038/s42004-019-0254-9 | “Antithrombotic property of graphene oxide depends on loading capacities, conformational changes, and interaction of plasma proteins with graphene oxide” |
10.3389/fchem.2021.685789 | 102,631,284 | Over the decades, the application of mechanical force to influence chemical reactions has been called by various names: mechanochemistry, tribochemistry, mechanical alloying, to name but a few. The evolution of these terms has largely mirrored the understanding of the field. But what is meant by these terms, why have t... | 10.1038/s42004-021-00582-3 | The article addresses the standardization of technical terms in mechanochemistry and proposes a new guideline for the reporting of experimental conditions of mechanochemical reactions |
10.1002/wat2.1480 | 17,204,158 | Abstract Armed conflict has the potential to disrupt water systems that are crucial to environmental and human wellbeing. Yet there is no comprehensive overview of scientific evidence on the impact of armed conflicts on water resources and their management. This paper assesses the relevant scientific evidence through a... | 10.1038/s41893-023-01070-3 | A review of the scientific evidence for the effects of armed conflicts on water resources and water management. |
10.12681/historein.242 | 30,738,287 | Review of: Christian Promitzer, Sevasti Trubeta and Marius Turda (eds), Health, Hygiene and Eugenics in Southeastern Europe to 1945, Budapest: Central European UP, 2011. 440 pp. | 10.1038/s41893-023-01070-3 | A book chapter that presents key information about rivers in the territory of Ukraine. |
10.1093/oso/9780198842286.001.0001 | 17,002,407 | Working memory refers to how we keep track of what we are doing moment to moment throughout our waking lives. It allows us to remember what we have just done, focus on what we are doing now, to solve problems, be creative, think about what we will be doing in the next few seconds, and continually to update in our mind ... | 10.1038/s44159-023-00149-0 | This chapter presents an updated version of the multicomponent model of working memory, providing a broad theoretical framework enabling more detailed analysis of its components, and demonstrating its use beyond the laboratory |
10.1080/17470218.2015.1136657 | 89,915,504 | Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling ... | 10.1038/s44159-023-00149-0 | This article suggests that executive control in working memory might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks |
10.1080/02724980443000241 | 123,574,253 | We conducted two experiments using a modified version of the N-Back task. For younger adults, there was an abrupt increase in reaction time of about 250 ms in passing from N = 1 to N > 1, indicating a cost associated with switching of the focus of attention within working memory. Response time costs remained constan... | 10.1038/s44159-023-00149-0 | This study suggests that switching the focus of attention is a process that shows a specific age-related deficit that is observed through inaccuracies in responding |
10.1111/1467-9280.t01-1-01430 | 20,654,108 | A meta-analytic study was conducted to examine the hypothesis that aerobic fitness training enhances the cognitive vitality of healthy but sedentary older adults. Eighteen intervention studies published between 1966 and 2001 were entered into the analysis. Several theoretically and practically important results were ob... | 10.1038/s44159-023-00149-0 | This meta-analysis assesses effects of aerobic fitness training on the cognitive vitality of older adults, showing that fitness training has selective benefits for cognition that are most robust for executive control |
10.1002/anie.201508933 | 80,304,920 | Abstract The synthesis of four different bidentate hybrid NHC‐thioether ligands is presented. The corresponding palladium nanoparticles are stable in various solvents, depending on the ligand used, and show high chemoselectivity in the hydrogenation of olefins. The solubility of the nanoparticles can be switched multip... | 10.1038/s41929-021-00607-z | Application of bidentate NHC ligands to modulate stability and solubility of nanoparticles |
10.1002/anie.201407758 | 79,971,815 | Abstract Controlling the synthesis of stable metal nanoparticles in water is a current challenge in nanochemistry. The strategy presented herein uses sulfonated N‐heterocyclic carbene (NHC) ligands to stabilize platinum nanoparticles (PtNPs) in water, under air, for an indefinite time period. The particles were prepare... | 10.1038/s41929-021-00607-z | Solubility of nanoparticles in water by NHCs with charged sidegroups |
10.1002/anie.201800367 | 41,478,317 | Abstract Reported here is the chelate effect as a design principle for tuning heterogeneous catalysts for electrochemical CO 2 reduction. Palladium functionalized with a chelating tris‐N‐heterocyclic carbene (NHC) ligand (Pd‐timtmb Me ) exhibits a 32‐fold increase in activity for electrochemical reduction of CO 2 to C1... | 10.1038/s41929-021-00607-z | Increased activity towards CO 2 reduction by tridentate NHC ligands |
10.1063/1.1482797 | 38,200,389 | We present an optical biosensor with unprecedented sensitivity for detection of unlabeled molecules. Our device uses optical resonances in a dielectric microparticle (whispering gallery modes) as the physical transducing mechanism. The resonances are excited by evanescent coupling to an eroded optical fiber and detecte... | 10.1038/s43586-021-00079-2 | First demonstration of molecular biosensing (biotin–streptavidin) on a WGM sensor |
10.1073/pnas.0808988106 | 20,554,965 | We report the label-free, real-time optical detection of Influenza A virus particles. Binding of single virions is observed from discrete changes in the resonance frequency/wavelength of a whispering-gallery mode excited in a microspherical cavity. We find that the magnitude of the discrete wavelength-shift signal can ... | 10.1038/s43586-021-00079-2 | First demonstration of single virus particle detection on a WGM sensor |
10.1002/cpch.23 | 71,618,783 | Abstract Whispering gallery mode (WGM) sensors are a class of powerful analytical techniques defined by the measurement of changes in the local refractive index at or near the sensor surface. When functionalized with target‐specific capture agents, analyte binding can be measured with very low limits of detection. Ther... | 10.1038/s43586-021-00079-2 | This method paper details the development and optimization of immunoassays for WGM biosensors |
10.1146/annurev-anchem-071015-041742 | 122,085,720 | Optical resonator sensors are an emerging class of analytical technologies that use recirculating light confined within a microcavity to sensitively measure the surrounding environment. Bolstered by advances in microfabrication, these devices can be configured for a wide variety of chemical or biomolecular sensing appl... | 10.1038/s43586-021-00079-2 | This review discusses various optical resonator sensing platforms and highlights recent developments in sensing of biologics and other analytes using optical sensors |
10.1038/ncomms12311 | 83,388,287 | Abstract Label-free bio-sensing is a critical functionality underlying a variety of health- and security-related applications. Micro-/nano-photonic devices are well suited for this purpose and have emerged as promising platforms in recent years. Here we propose and demonstrate an approach that utilizes the optical spri... | 10.1038/s43586-021-00079-2 | First experiment describing single-molecule detection based on the dynamics of an optomechanical system |
10.1126/sciadv.1603044 | 81,693,313 | Single-molecule enzyme-reactant interactions and the linked conformational changes are monitored via an optical microcavity sensor. | 10.1038/s43586-021-00079-2 | This paper demonstrates that WGMs are sensitive to conformational changes in proteins such as polymerase enzymes |
10.1002/lpor.202000135 | 29,314,528 | Abstract Whispering gallery mode (WGM) resonators have been exploited as a highly sensitive and efficient sensing technique in the past few years. They offer the advantages of ultrahigh sensitivity, compact size, and label‐free sensing capability. More recently, with the rapid development of microfluidic technologies, ... | 10.1038/s43586-021-00079-2 | This recent review covers integration of varying WGM geometries with microfluidic systems |
10.1073/pnas.1502029112 | 123,442,674 | Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback–controlled confinement of single cells wh... | 10.1038/s42254-018-0001-7 | This paper shows that mechanical confinement by the atomic force microscope cantilever can be used to slow down and stop cells progressing through mitosis |
10.1038/s41467-017-01147-6 | 61,947,666 | Abstract To divide, most animal cells drastically change shape and round up against extracellular confinement. Mitotic cells facilitate this process by generating intracellular pressure, which the contractile actomyosin cortex directs into shape. Here, we introduce a genome-scale microcantilever- and RNAi-based approac... | 10.1038/s42254-018-0001-7 | This paper presents a genome-scale AFM-based screen that discovers unexpected genes that animal cells use to round for mitosis |
10.1038/s41598-017-05383-0 | 101,711,866 | Abstract We present a procedure that allows a reliable determination of the elastic (Young’s) modulus of soft samples, including living cells, by atomic force microscopy (AFM). The standardized nanomechanical AFM procedure (SNAP) ensures the precise adjustment of the AFM optical lever system, a prerequisite for all kin... | 10.1038/s42254-018-0001-7 | This paper introduces an approach to reducing the variability in extracting the elastic moduli of soft samples and reports on its validation in various laboratories to establish it as a standard method |
10.1038/s41598-017-01784-3 | 123,035,127 | Abstract Force-displacement ( F - Z ) curves are the most commonly used Atomic Force Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials like living cells. Yet a theoretical framework has been lacking that allows the post-processing of F - Z data to extract their viscoelastic cons... | 10.1038/s42254-018-0001-7 | This paper introduces a powerful approach to extracting elastic and viscous parameters from FD curves |
10.1073/pnas.0601881103 | 58,475,502 | In this work, we provide evidence of a mechanism to reinforce the strength of an icosahedral virus by using its genomic DNA as a structural element. The mechanical properties of individual empty capsids and DNA-containing virions of the minute virus of mice are investigated by using atomic force microscopy. The stiffne... | 10.1038/s42254-018-0001-7 | This paper shows that the viral genome interacts with and mechanically reinforces the viral capsid |
10.1146/annurev-conmatphys-031214-014710 | 104,387,301 | Self-propelled particles include both self-phoretic synthetic colloids and various microorganisms. By continually consuming energy, they bypass the laws of equilibrium thermodynamics. These laws enforce the Boltzmann distribution in thermal equilibrium: The steady state is then independent of kinetic parameters. In con... | 10.1038/s42254-020-0152-1 | Review of theoretical descriptions of motility-induced phase separation in active matter |
10.1126/science.285.5430.1042 | 125,070,774 | Heating of a ruthenium surface on which carbon monoxide and atomic oxygen are coadsorbed leads exclusively to desorption of carbon monoxide. In contrast, excitation with femtosecond infrared laser pulses enables also the formation of carbon dioxide. The desorption is caused by coupling of the adsorbate to the phonon ba... | 10.1038/s43246-021-00220-4 | An illustration of contrasting reaction pathways on a bulk metal surface when initiated by laser-induced hot substrate electrons in comparison to thermal activation |
10.1002/anie.202101639 | 109,235,573 | Abstract Here, we demonstrate the simultaneous utilization of both the hot carriers (electrons and holes) in the photocatalytic transformation of benzylamine to N‐benzylidenebenzylamine and the scope of reaction has also been successfully demonstrated with catalytic oxidation of 4‐methoxybenzylamine. The wavelength‐dep... | 10.1038/s43246-021-00220-4 | Demonstration of the role of plasmonic hot charge carriers and excitation-dependent tuning of their potential energy for oxidative C-N bond formation |
10.1126/science.aac5443 | 62,433,960 | Improving electron harvesting Small metal nanostructures generate electrons from light by creating surface plasmons, which can transfer “hot electrons” to a semiconductor. The efficiency of this process, however, is often low because of electron-electron scattering. Wu et al. demonstrate a pathway that allows the plasm... | 10.1038/s43246-021-00220-4 | Experimental evidence of direct electron transfer LSPR decay at strongly coupled metal/semiconductor interface |
10.1038/s41467-018-04630-w | 62,125,825 | Abstract Localized surface plasmon resonance (LSPR)-induced hot-carrier transfer is a key mechanism for achieving artificial photosynthesis using the whole solar spectrum, even including the infrared (IR) region. In contrast to the explosive development of photocatalysts based on the plasmon-induced hot electron transf... | 10.1038/s43246-021-00220-4 | An experimental report on high quantum yields and long-lived charge separation plasmon-induced transit carrier transfer mechanism in CdS/CuS heterostructures |
10.1093/nar/gkz310 | 41,659,560 | Abstract Secondary metabolites produced by bacteria and fungi are an important source of antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad applications in identifying and characterizing new compounds as well as in metabolic engineering. Since 2011, the ‘antibiotics and secondar... | 10.1038/s43586-023-00205-2 | This work presents the most significant genome mining platform for natural products, covering a wide range of compounds, and is a recommended read for anyone interested in natural product research. |
10.1093/bioinformatics/btx400 | 121,957,186 | Abstract Summary Nonribosomally synthesized peptides (NRPs) are natural products with widespread applications in medicine and biotechnology. Many algorithms have been developed to predict the substrate specificities of nonribosomal peptide synthetase adenylation (A) domains from DNA sequences, which enables prioritizat... | 10.1038/s43586-023-00205-2 | This work discusses how SANDPUMA has aided NRP discovery and continues to provide valuable predictions for researchers involved in NRP research. |
10.1002/pmic.202100256 | 142,997,696 | Abstract Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques. Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances of proteins and peptides in complex biological samples. Several methods have been developed and adapted for accurate quantification based... | 10.1038/s43586-023-00205-2 | This critical review article discusses isobaric labelling strategies for quantitative proteomics and peptidomics applications as well as current limitations and future outlooks. |
10.1002/anie.201609079 | 125,092,475 | Abstract Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more than 20 marketed drugs, such as antibacterials (penicillin, vancomycin), antitumor compounds (bleomycin), and immunosuppressants... | 10.1038/s43586-023-00205-2 | This comprehensive review about NRPs explains biosynthesis, structures and bioactivity or NRPs. |
10.1111/1365-2435.12855 | 68,790,001 | Summary Like many other venomous organisms, scorpions use their venom in defence against predators. Scorpions apply their venomous stinger by extending the caudal part of the body, the metasoma, forward towards the attacker. There are considerable differences in metasoma morphology among scorpion species, and these may... | 10.1038/s43586-023-00205-2 | This work presents a fascinating investigation into the different methods of the defensive behaviours of scorpions, measuring both the speed and frequency of stings in response to stimuli. |
10.1038/ncomms11436 | 62,549,989 | Abstract Large-scale mass spectrometry-based peptidomics for drug discovery is relatively unexplored because of challenges in peptide degradation and identification following tissue extraction. Here we present a streamlined analytical pipeline for large-scale peptidomics. We developed an optimized sample preparation pr... | 10.1038/s43586-023-00205-2 | This article introduces a comprehensive analytical workflow for large-scale mammalian peptidomics studies, detailing procedures ranging from sample preparation to data analysis. |
10.1073/pnas.1423857112 | 82,624,662 | More than 100 species of venomous cone snails (genus Conus ) are highly effective predators of fish. The vast majority of venom components identified and functionally characterized to date are neurotoxins specifically targeted to receptors, ion channels, and transporters in the nervous system of prey, predators, or com... | 10.1038/s43586-023-00205-2 | This article is interesting for researchers involved in peptide hormone research, discussing the weaponization of peptide hormones by animals. |
10.1038/sdata.2016.18 | 83,515,894 | Abstract There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders—representing academia, industry, funding agencies, and scholarly publishers—have come together to design and jointly endorse a concise and measureable set of principles that we refer to a... | 10.1038/s43586-023-00205-2 | This work on the FAIR Guiding Principles is an essential read for all researchers as data management will become more important as data continue to be generated worldwide. |
10.1111/joim.12895 | 107,396,877 | Abstract Background Patients with postural tachycardia syndrome ( POTS ) experience chronic symptoms of orthostatic intolerance. There are minimal data detailing the demographics, clinical features and clinical course of this condition. This online, community‐based survey highlights patients’ experience with POTS . It ... | 10.1038/s44161-022-00194-7 | This paper describes the patient experience of POTS, with 75% of participants reporting misdiagnosis and a median diagnostic delay of 2 years. |
10.1007/s11906-022-01216-2 | 128,019,621 | Abstract Purpose of Review To discuss the interplay behind how a high-fibre diet leads to lower blood pressure (BP) via the gut microbiome. Recent Findings Compelling evidence from meta-analyses support dietary fibre prevents the development of cardiovascular disease and reduces BP. This relation is due to gut microbia... | 10.1038/s44161-022-00204-8 | A review article that presents the latest evidence on dietary fibre and blood pressure. |
10.1101/2022.11.17.516695 | 140,340,263 | Abstract Dietary fibre regulates blood pressure (BP) through gut microbial production of acidic metabolites known as short-chain fatty acids (SCFAs). The specific mechanisms of how SCFAs regulate BP are still emerging. We hypothesised that acidic metabolites that are abundant in the large intestine may activate proton-... | 10.1038/s44161-022-00204-8 | This paper reports on a new G-protein-coupled receptor that lowers blood pressure via the fiber–microbiome–SCFA axis. |
10.1073/pnas.1104047108 | 62,119,649 | Attention selects which aspects of sensory input are brought to awareness. To promote survival and well-being, attention prioritizes stimuli both voluntarily, according to context-specific goals (e.g., searching for car keys), and involuntarily, through attentional capture driven by physical salience (e.g., looking tow... | 10.1038/s44159-022-00053-z | This study demonstrates the two-phase VMAC design: participants are slower to respond to a target when the display contained a distractor that has previously been paired with high-value reward than when no such distractor was present |
10.1073/pnas.1101328108 | 20,609,825 | How do we make decisions when confronted with several alternatives (e.g., on a supermarket shelf)? Previous work has shown that accumulator models, such as the drift-diffusion model, can provide accurate descriptions of the psychometric data for binary value-based choices, and that the choice process is guided by visua... | 10.1038/s44159-022-00053-z | This paper extends the aDDM to account for multi-alternative value-based decisions |
10.1002/acp.3814 | 96,919,408 | Abstract The practice assignments in a mathematics textbook or course can be arranged so that most of the problems relating to any particular concept are massed together in a single assignment, or these related problems can be distributed across many assignments–a format known as spaced practice. Here we report the res... | 10.1038/s44159-022-00089-1 | This study demonstrates significant benefits of spacing over massed learning on 11–12-year-old students’ mathematics knowledge |
10.1002/acp.3539 | 11,304,507 | Summary Despite the prevalence of the spacing effect in the psychological literature, the impact of lesson timing has not yet been fully explored in real classrooms. The current study examined whether spacing could improve long‐term retention of both factual and critical thinking curriculum‐based teaching materials for... | 10.1038/s44159-022-00089-1 | This study demonstrates significant long-term benefits of spacing on 9–12-year-old children’s ability to evaluate the credibility of information on websites |
10.1038/s41539-021-00110-x | 132,635,281 | Abstract We investigated whether continuously alternating between topics during practice, or interleaved practice, improves memory and the ability to solve problems in undergraduate physics. Over 8 weeks, students in two lecture sections of a university-level introductory physics course completed thrice-weekly homework... | 10.1038/s44159-022-00089-1 | This study demonstrates significant benefits of distributing homework problems on retention and transfer of university students’ physics knowledge over an academic term |
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