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10.18061/dsq.v30i1.1052 | 6,413,016 | No abstract available | 10.1038/s44159-022-00099-z | In this commentary, autistic thinker and activist Mel Baggs implores researchers to view autistic people, especially those who think and communicate in non-traditional ways, as fully human |
10.1017/s0140525x18001826 | 20,647,434 | Abstract Progress in psychological science can be limited by a number of factors, not least of which are the starting assumptions of scientists themselves. We believe that some influential accounts of autism rest on a questionable assumption that many of its behavioral characteristics indicate a lack of social interest... | 10.1038/s44159-022-00099-z | This perspective piece challenges the notion that autism is fundamentally characterized by diminished social motivation and urges researchers to take autistic testimony seriously in research |
10.1177/1362361305051398 | 104,148,161 | The authors conclude from a range of literature relevant to the autistic condition that atypical strategies for the allocation of attention are central to the condition. This assertion is examined in the context of recent research, the diagnostic criteria for autism in DSMIV and ICD-10, and the personal experiences of ... | 10.1038/s44159-022-00099-z | This autistic-led article presents ‘monotropism’, an alternative account of autistic cognition that is widely discussed in the autistic community but has received little attention from established autism researchers |
10.3390/ijerph17197121 | 103,016,903 | There is both an intuitive and theoretical link between self-determination and quality of life for people with intellectual and developmental disabilities. Theoretically, definitions of self-determination have framed the construct with regard to its contribution to a person’s overall quality of life, while theoretical ... | 10.1038/s44159-022-00099-z | This paper presents a powerful analysis on the importance of self-determination to the lives of people with intellectual and developmental disabilities |
10.1177/1362361314529627 | 62,411,356 | The rise in the measured prevalence of autism has been accompanied by much new research and research investment internationally. This study sought to establish whether the pattern of current UK autism research funding maps on to the concerns of the autism community. Interviews and focus groups were conducted with autis... | 10.1038/s44159-022-00099-z | This large-scale consultation with members of the autistic and autism communities demonstrates the disconnect between what gets researched and what community members want to be researched |
10.3389/fpsyg.2021.727542 | 134,533,685 | There has been a focus on autistic-led and participatory research in autism research, but minimal discussion about whether the field is hospitable to autistic involvement. While the focus on participatory and/or autistic-led research is abundantly welcome, a wider conversation should also happen about how autistic peop... | 10.1038/s44159-022-00099-z | This piece is a powerful reflection into how the differing roles of autistic activist and autism researcher can intersect to inform autism research |
10.1177/1362361318786721 | 62,418,670 | Participatory research methods connect researchers with relevant communities to achieve shared goals. These methods can deliver results that are relevant to people’s lives and thus likely to have a positive impact. In the context of a large and growing body of autism research, with continued poor implementation, and so... | 10.1038/s44159-022-00099-z | This co-produced paper identifies five topics relevant to building a community of practice in participatory research, offering a useful guide for early-career and more senior researchers |
10.1002/idm2.12067 | 138,217,638 | Abstract Grain boundaries (GBs) can be treated as two‐dimensional (2‐D) interfacial phases (also called “complexions”) that can undergo interfacial phase‐like transitions. As bulk phase diagrams and calculation of phase diagram (CALPHAD) methods serve as a foundation for modern materials science, we propose to extend t... | 10.1038/s43246-023-00335-w | A perspective paper reviewed a series of transformative studies to compute grain boundary “phase” diagrams (including predicting the properties of grain boundaries in high-entropy alloys) and related concepts of grain boundary disordering and transitions, with a discussion on extending this research to high-entropy gra... |
10.1038/srep15758 | 41,520,497 | Abstract We address a fundamental problem that is systematically encountered when modeling real-world complex systems of societal relevance: the limitedness of the information available. In the case of economic and financial networks, privacy issues severely limit the information that can be accessed and, as a conseque... | 10.1038/s42254-021-00322-5 | In this paper the entropy-based approach is tailored to the reconstruction of financial networks. |
10.1038/ncomms14416 | 20,478,043 | Abstract Following the financial crisis of 2007–2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network mo... | 10.1038/s42254-021-00322-5 | This paper connects the stability of financial networks to the presence of specific topological structures. |
10.1287/mnsc.47.2.236.9835 | 29,302,152 | We consider default by firms that are part of a single clearing mechanism. The obligations of all firms within the system are determined simultaneously in a fashion consistent with the priority of debt claims and the limited liability of equity. We first show, via a fixed-point argument, that there always exists a “cle... | 10.1038/s42254-021-00322-5 | This paper introduces the foundational framework for clearing of interbank obligations and derives key results on the existence of solutions. |
10.1111/mafi.12272 | 81,415,542 | Abstract We introduce a general model for the balance‐sheet consistent valuation of interbank claims within an interconnected financial system. Our model represents an extension of clearing models of interdependent liabilities to account for the presence of uncertainty on banks' external assets. At the same time, it al... | 10.1038/s42254-021-00322-5 | This paper shows that different previously unrelated models of financial contagion can all be mapped to valuation models on a network. |
10.1098/rspa.2009.0410 | 123,100,617 | This paper develops an analytical model of contagion in financial networks with arbitrary structure. We explore how the probability and potential impact of contagion is influenced by aggregate and idiosyncratic shocks, changes in network structure and asset market liquidity. Our findings suggest that financial systems ... | 10.1038/s42254-021-00322-5 | This is one of the first papers to show that financial networks may be robust yet fragile, meaning that contagion events are rare but extremely severe. |
10.1126/science.262.5131.218 | 41,502,062 | A method for confining electrons to artificial structures at the nanometer lengthscale is presented. Surface state electrons on a copper(111) surface were confined to closed structures (corrals) defined by barriers built from iron adatoms. The barriers were assembled by individually positioning iron adatoms with the ti... | 10.1038/s43586-021-00033-2 | This article demonstrates the ability of manipulating atoms and constructing artificial quantum structures |
10.1063/1.122948 | 100,548,159 | Force sensors are key elements of atomic force microscopes and surface profilometers. Sensors with an integrated deflection meter are particularly desirable. Here, quartz tuning forks as used in watches are utilized as force sensors. A novel technique is employed which simplifies the interpretation of the data and incr... | 10.1038/s43586-021-00033-2 | This work pioneers qPlus-based AFM, which was demonstrated to surpass the spatial resolution of STM |
10.1038/s41467-017-02635-5 | 100,548,819 | Abstract Scanning probe microscopy has been extensively applied to probe interfacial water in many interdisciplinary fields but the disturbance of the probes on the hydrogen-bonding structure of water has remained an intractable problem. Here, we report submolecular-resolution imaging of the water clusters on a NaCl(00... | 10.1038/s43586-021-00033-2 | This article develops hydrogen-sensitive AFM for probing water molecules with submolecular resolution |
10.1126/science.aac8703 | 26,956,174 | EPR, one atom at a time Electron paramagnetic resonance (EPR) usually detects atoms with unpaired electrons as ensemble averages. Baumann et al. used a spin-polarized scanning tunneling microscope tip to measure EPR spectra of single iron atoms adsorbed on a magnesium oxide surface at cryogenic temperatures. The measur... | 10.1038/s43586-021-00033-2 | This article develops the first ESR-STM for measuring ESR and quantum coherence with atomic precision |
10.1126/science.280.5370.1732 | 20,522,539 | Vibrational spectra for a single molecule adsorbed on a solid surface have been obtained with a scanning tunneling microscope (STM). Inelastic electron tunneling spectra for an isolated acetylene (C 2 H 2 ) molecule adsorbed on the copper (100) surface showed an increase in the tunneling conductance at 358 millivolts, ... | 10.1038/s43586-021-00033-2 | This article develops IETS, enabling detection of single-molecule vibrations for chemical identification |
10.1073/pnas.152330199 | 100,738,448 | We report a microarray of cantilevers to detect multiple unlabeled biomolecules simultaneously at nanomolar concentrations within minutes. Ligand-receptor binding interactions such as DNA hybridization or protein recognition occurring on microfabricated silicon cantilevers generate nanomechanical bending, which is dete... | 10.1038/s43586-021-00033-2 | This pioneering microcantilever-based work directly detects the binding of complementary strands of DNA |
10.1002/esp.592 | 20,744,171 | Abstract In Central Yakutia, frozen river banks are affected by a combination of thermal and mechanical erosion. Exceptional bank retreat of up to 40 m per year is observed. This results from ground thawing produced by heat transfer from the flow of water through the frozen ground, followed by mechanical transport of th... | 10.1038/s43017-022-00268-x | This paper presents theoretical model development and field data of bank erosion in permafrost-affected rivers |
10.5194/tc-8-1777-2014 | 80,623,266 | Abstract. Sea ice limits the interaction of the land and ocean water in the Arctic winter and influences this interaction in the summer by governing the fetch. In many parts of the Arctic, the open-water season is increasing in duration and summertime sea-ice extents are decreasing. Sea ice provides a first-order contr... | 10.1038/s43017-022-00268-x | The mapping of the onset of open water and its duration along the entire Arctic coast from remote-sensing data shows a 1.5–3-fold expansion of sea-ice-free conditions over the past three decades |
10.1126/science.354.6316.1090 | 59,070,790 | How small startups are vying with corporate behemoths for quantum supremacy. | 10.1038/s41928-022-00738-6 | This article summarizes various qubit technologies that are being investigated for applications in quantum computing |
10.1002/alz.051496 | 127,754,222 | Abstract Background Given projected increases in population growth and population aging, the number of people with dementia is expected to increase in the future. Characterizing the distribution and magnitude of the anticipated growth is critical for public health planning and prioritization of resources. This study ai... | 10.1038/s43587-022-00344-3 | This paper by the Global Burden of Disease 2019 Dementia Forecasting Collaborators forecasts dementia prevalence in 2050 on the basis of population increase and different risk factors. |
10.1002/alz.12116 | 104,171,655 | Abstract Introduction The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer's disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety ... | 10.1038/s43587-022-00344-3 | This paper reports that repetitive negative thinking is associated with decline in cognitive domains affected early in dementia and with biomarkers of Alzheimer disease. |
10.1177/0956797610372634 | 83,005,721 | In this article, we examine the concept of emotional inertia as a fundamental property of the emotion dynamics that characterize psychological maladjustment. Emotional inertia refers to the degree to which emotional states are resistant to change. Because psychological maladjustment has been associated with both emotio... | 10.1038/s43587-022-00344-3 | This paper shows the relationship between emotional inertia and depression. |
10.1145/3306346.3322937 | 19,068,312 | Imaging objects outside a camera's direct line of sight has important applications in robotic vision, remote sensing, and many other domains. Time-of-flight-based non-line-of-sight (NLOS) imaging systems have recently demonstrated impressive results, but several challenges remain. Image formation and inversion models h... | 10.1038/s42254-020-0174-8 | A fast and accurate wave-optics method for 3D NLOS imaging at interactive frame-rates |
10.1111/cge.13455 | 74,951,466 | The nuclear lamins are important members of the intermediate filament (IF) family of proteins, involved in structural support and regulation of the nuclear lamina. Different mutations in various members of these type V IF proteins produce a staggering range of human disease phenotypes, which collectively have been term... | 10.1038/s43587-022-00324-7 | A review article that describes the mechanisms of age dependent heart dysfunction. |
10.1126/science.1127168 | 20,707,967 | Mutations in the nuclear structural protein lamin A cause the premature aging syndrome Hutchinson-Gilford progeria (HGPS). Whether lamin A plays any role in normal aging is unknown. We show that the same molecular mechanism responsible for HGPS is active in healthy cells. Cell nuclei from old individuals acquire defect... | 10.1038/s43587-022-00324-7 | A research article that demonstrates conserved nuclear remodeling in progeria syndrome and aged donor fibroblasts. |
10.3390/ijms20143494 | 107,112,486 | Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in se... | 10.1038/s44161-022-00110-z | This Review article presents platelets as crucial players in sepsis |
10.1038/s41467-020-14317-w | 82,807,417 | Abstract In the Caenorhabditis elegans zygote, PAR protein patterns, driven by mutual anatagonism, determine the anterior-posterior axis and facilitate the redistribution of proteins for the first cell division. Yet, the factors that determine the selection of the polarity axis remain unclear. We present a reaction-dif... | 10.1038/s42254-022-00461-3 | This study uses a reaction–diffusion model to demonstrate that axis selection during Par polarization in the C. elegans zygote depends on the local surface-to-volume ratio, highlighting the importance of cell geometry for pattern formation |
10.1126/science.1208619 | 124,761,762 | Patterning of Caenorhabditis elegans zygotes involves passive as well as active mechanisms. | 10.1038/s42254-022-00461-3 | The study shows that PAR polarity arises from an interplay between reaction–diffusion dynamics and advective transport |
10.1073/pnas.1810896115 | 38,319,823 | Mechanochemical processes in thin biological structures, such as the cellular cortex or epithelial sheets, play a key role during the morphogenesis of cells and tissues. In particular, they are responsible for the dynamical organization of active stresses that lead to flows and deformations of the material. Consequentl... | 10.1038/s42254-022-00461-3 | Combining the theory of active fluids with deformable surfaces, this theoretical study shows, by means of a minimal mathematical model, how mechanochemical feedback can lead to shape deformations |
10.1126/science.1154413 | 82,943,559 | In the bacterium Escherichia coli , the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min pro... | 10.1038/s42254-022-00461-3 | Combining experimental measurements with a reaction–diffusion model, this study analyses the Min protein patterns, providing a fundamental contribution to the modern study of guided pattern formation |
10.1126/science.1092586 | 125,091,624 | The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. Wi... | 10.1038/s42254-022-00461-3 | This study uses X-ray crystallography of the N-terminus of Drosophila amphiphysin to show that the BAR domain has a curved shape and can have both a curvature-sensing and membrane-bending function |
10.1038/s41467-017-00979-6 | 62,033,476 | Abstract Surface contraction waves (SCWs) in oocytes and embryos lead to large-scale shape changes coupled to cell cycle transitions and are spatially coordinated with the cell axis. Here, we show that SCWs in the starfish oocyte are generated by a traveling band of myosin II-driven cortical contractility. At the front... | 10.1038/s42254-022-00461-3 | Combining quantitative imaging of starfish oocytes with mathematical modelling, this study demonstrates how a decaying gradient of cdk1-cyclinB can guide a travelling mechanical response across the cell membrane |
10.1038/s41567-021-01213-3 | 62,389,943 | Abstract The healthy growth and maintenance of a biological system depends on the precise spatial organization of molecules within the cell through the dissipation of energy. Reaction–diffusion mechanisms can facilitate this organization, as can directional cargo transport orchestrated by motor proteins, by relying on ... | 10.1038/s42254-022-00461-3 | This study combines theoretical analysis with in vitro experiments on Min proteins and DNA origami nanostructures to propose diffusiophoresis, guided by protein patterns, as a motor-free directional transport mechanism of non-specific cargo |
10.1073/pnas.1401025111 | 20,450,096 | Significance The process of DNA segregation is of central importance for all organisms. Although the basic mechanism of eukaryotic mitosis is relatively well established, the most common mechanism used for bacterial DNA segregation has been unclear. ParA ATPases form dynamic patterns on the bacterial nucleoid to spatia... | 10.1038/s42254-022-00461-3 | Using a cell-free reconstitution of ATP-driven cargo transport, this study provides evidence of chemophoretic motion of surface-confined plasmid cargo guided by a protein gradient |
10.1098/rstb.2017.0115 | 82,969,114 | Eukaryote cells have flexible membranes that allow them to have a variety of dynamical shapes. The shapes of the cells serve important biological functions, both for cells within an intact tissue, and during embryogenesis and cellular motility. How cells control their shapes and the structures that they form on their s... | 10.1038/s42254-022-00461-3 | This review provides a state-of-the-art summary of the theoretical models studying the interaction between curved membrane proteins and shape deformations |
10.1002/anie.201808750 | 61,680,380 | Abstract The bacterial Min protein system was encapsulated in giant unilamellar vesicles (GUVs). Using confocal fluorescence microscopy, we identified several distinct modes of spatiotemporal patterns inside spherical GUVs. For osmotically deflated GUVs, the vesicle shape actively changed in concert with the Min oscill... | 10.1038/s42254-022-00461-3 | This study uses confocal microscopy to demonstrate spatiotemporal patterning of Min proteins in GUVs accompanied by changes of the vesicle shape and its mechanical properties, proposing a mechanism for shape control based entirely on self-organized protein patterns |
10.1126/science.aan5780 | 62,154,069 | Integrating glucose and fat Consuming too much glucose makes you fat, but it is unclear how this conversion is mediated by the body. Glycolysis links to gene transcription via the essential coenzyme nicotinamide adenine dinucleotide in its oxidized state (NAD + ). Ryu et al. found that compartmentalized NAD + synthesis... | 10.1038/s42255-020-00285-4 | This study shows a switch from nuclear to cytoplasmic NAD + production that sustains adipogenic differentiation through the PARP-dependent regulation of C/EBPβ |
10.1126/science.1164097 | 109,445,740 | Chromatin Modifier Modulates Gene Expression Modification of chromatin structure is usually thought of as a global, relatively nonspecific way of modulating gene expression. However, Wellen et al. (p. 1076 ; see the Perspective by Rathmell and Newgard ) demonstrate that such regulation helps link growth factor–stimulat... | 10.1038/s42255-020-00285-4 | This study identifies ACLY as a modulator of histone acetylation through the nuclear production of acetyl-CoA from citrate |
10.3389/fcvm.2021.680109 | 128,874,455 | Pulmonary arterial hypertension (PAH) is a progressive life-threatening disease. The notion that autoimmunity is associated with PAH is widely recognized by the observations that patients with connective tissue diseases or virus infections are more susceptible to PAH. However, growing evidence supports that the patient... | 10.1038/s44161-022-00104-x | A Review that presents the adaptive immune response in lungs with PAH |
10.1084/jem.20071008 | 103,713,076 | Pulmonary arterial remodeling characterized by increased vascular smooth muscle density is a common lesion seen in pulmonary arterial hypertension (PAH), a deadly condition. Clinical correlation studies have suggested an immune pathogenesis of pulmonary arterial remodeling, but experimental proof has been lacking. We s... | 10.1038/s44161-022-00104-x | A paper that reports pulmonary vascular remodeling in mice with ovalbumin-induced asthma |
10.1002/anie.201612462 | 19,021,093 | Abstract Recent developments of stereoselective biocatalytic and chemocatalytic methods are discussed. The review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthetic considerations and analysis. The transformations presented are organized accord... | 10.1038/s41929-019-0385-5 | This Review covers many examples of designing retrosynthetic routes with enzymes. |
10.1146/annurev-biochem-030409-143718 | 104,416,613 | Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other than those for which they evolved. Here, we discuss the structural, mechanistic, and evolutionary implications of this manifestation of infidelity of molecular recognition. We define promiscuity and related phenomena and also a... | 10.1038/s41929-019-0385-5 | An in-depth Review of how to recognize and understand enzyme promiscuity. |
10.1126/science.aao1482 | 20,624,952 | Teaching an enzyme to switch sites There has been a recent flurry of activity in modifying enzymes to conduct unnatural chemical reactions more cleanly or selectively than synthetic chemical catalysts. Hammer et al. now report application of a cytochrome P450 variant to an oxidation that has largely eluded efficient ca... | 10.1038/s41929-019-0385-5 | This study demonstrates how a new enzyme activity can be obtained by promoting an alternative reaction pathway. |
10.1126/science.1231434 | 62,268,984 | Putting a C in Cytochrome Cytochrome P450 enzymes oxidize hydrocarbons using a highly reactive iron oxo intermediate. Much research has focused on tuning the protein structure to broaden the range of hydrocarbons that can be functionalized. Coelho et al. (p. 307 , published online 20 December; see the Perspective by Na... | 10.1038/s41929-019-0385-5 | This report of a non-natural carbene-transfer reaction with an engineered haem enzyme laid the foundation for development of novel carbene and nitrene transferases. |
10.1073/pnas.1807027115 | 59,279,255 | Recently, heme proteins have been discovered and engineered by directed evolution to catalyze chemical transformations that are biochemically unprecedented. Many of these nonnatural enzyme-catalyzed reactions are assumed to proceed through a catalytic iron porphyrin carbene (IPC) intermediate, although this intermediat... | 10.1038/s41929-019-0385-5 | This report describes the first iron-carbene intermediate captured in a protein structure and is among the very few examples of a carbene intermediate bound to any type of iron complex |
10.1073/pnas.1901979116 | 125,142,202 | To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning into the directed evolution workflow. Combinatorial sequence space can be quite expensive to sample experimentally, but machin... | 10.1038/s41929-019-0385-5 | Machine learning-guided directed evolution of a haem protein for a non-native function facilitated exploration of sequence space. |
10.1002/smll.201402648 | 41,760,579 | The emerging graphene quantum dots (GQDs) and carbon dots (C‐dots) have gained tremendous attention for their enormous potentials for biomedical applications, owing to their unique and tunable photoluminescence properties, exceptional physicochemical properties, high photostability, biocompatibility, and small size. Th... | 10.1038/s43246-021-00214-2 | Structural and optical characteristics of CD and their use as bioimaging and biosensing probes |
10.1002/smll.201901673 | 107,255,226 | Abstract Intracellular pH is closely related with many biological processes, including cellular proliferation, apoptosis, endocytic processes, signal transduction, and enzymatic activity. The use of fluorescent probes has become an essential method for intracellular pH detection, but existing fluorescent probes have su... | 10.1038/s43246-021-00214-2 | Development of multifunctional RTCD for two-photon imaging and sensing of pH in vitro and in vivo |
10.1002/smll.202000680 | 123,023,409 | Abstract Carbon dots (CDs), with excellent optical property and cytocompatibility, are an ideal class of nanomaterials applied in the field of biomedicine. However, the weak response of CDs in the near‐infrared (NIR) region impedes their practical applications. Here, UV–vis–NIR full‐range responsive fluorine and nitrog... | 10.1038/s43246-021-00214-2 | Heteroatoms can significantly red-shift the emission and raise two-photon abosption efficiency of CD |
10.1002/ppsc.202000119 | 100,165,666 | Abstract Carbon dots possess versatile optical properties that have prompted their investigation in applications including photocatalysis, photovoltaics, imaging, and drug delivery, among others. However, the preparation of these nanodots is accompanied by the formation of fluorophores and intermediates, which can be d... | 10.1038/s43246-021-00214-2 | Purification profiles on a new CD system must be optimized to achieve high purity |
10.1116/1.572299 | 103,764,535 | Synthesis of ammonia from the elements (N2+3H2→2NH3) is performed over promoted iron catalysts at high pressures and temperatures (Haber–Bosch process) and represents, for about seventy years, one of the most important industrial catalytic reactions. This report is intended to demonstrate what kind of information on th... | 10.1038/s41929-021-00695-x | This report summarizes the surface science investigations on ammonia synthesis from N 2 and H 2 over single-crystal Fe surfaces |
10.1126/science.1106435 | 41,719,054 | The rate of ammonia synthesis over a nanoparticle ruthenium catalyst can be calculated directly on the basis of a quantum chemical treatment of the problem using density functional theory. We compared the results to measured rates over a ruthenium catalyst supported on magnesium aluminum spinel. When the size distribut... | 10.1038/s41929-021-00695-x | This paper presents the theoretical investigation of ammonia synthesis from N 2 and H 2 over a Ru metal surface |
10.1002/0470862106.ia087 | 123,689,534 | Abstract At present, some 50 different homoleptic transition (T) metal hydride complexes are known to occur in over 127 compounds that cover 47 structure types. The complexes form with T elements from group seven (Mn) to closed d‐shell elements of group twelve (Zn). While the great majority are centred by one T‐metal a... | 10.1038/s41929-021-00695-x | A book presenting the synthesis, structure and properties of solid-state transition metal complex hydrides. |
10.1002/cjoc.201800586 | 20,418,887 | Ammonia is feeding nearly half the world population and also holds the promise as a carbon‐free energy carrier. The development of ammonia synthesis and decomposition processes under milder conditions is a grand challenge for more than a century. Increasing effort is devoted to this area in recent years and encouraging... | 10.1038/s41929-021-00695-x | A review of research exploring alkali or alkaline earth metal amides, imides and hydrides for ammonia synthesis and decomposition |
10.1039/c9ee00802k | 103,791,423 | The vast difference in timescale of carrier transport detected in perovskite solar cells is associated with different kinetics processes involving electron, defects and large cations, which determines the device performance and I–V hysteresis. | 10.1038/s43586-021-00039-w | This article presents a comprehensive review of perovskite solar cells, with emphasis on the use of impedance spectroscopy for studying kinetics of bulk and interface processes |
10.1149/1945-7111/abc655 | 122,659,303 | Porous electrodes are prevalent in electrochemical devices. Electrochemical impedance spectroscopy (EIS) is widely used as a noninvasive, in situ characterization tool to investigate multi-phase (electronic, ionic, gaseous) transport and coupling interfacial reactions in porous electrodes. Interpretation of EIS data ne... | 10.1038/s43586-021-00039-w | This article is a systematic review of physics-based EIS models for porous electrodes with substantial mathematic details that may help model development |
10.1038/srep38568 | 107,217,799 | Abstract The electric characteristics of electric-double layer capacitors (EDLCs) are determined by their capacitance which is usually measured in the time domain from constant-current charging/discharging and cyclic voltammetry tests, and from the frequency domain using nonlinear least-squares fitting of spectral impe... | 10.1038/s43586-021-00039-w | This article presents a detailed description of the use of a CPE in cyclic voltammetry |
10.1126/sciadv.1701483 | 81,384,645 | Organic ligands can induce twist on nanometer-thin crystalline platelets and on their self-assembled ribbons. | 10.1038/s42004-021-00621-z | Oleic acid is shown to induce a shape change from flat to helicoidal CdSe nanoplatelets and their self-assembly into twisted ribbon after solvent evaporation |
10.1126/science.aan0202 | 125,324,550 | Conjugated covalent networks Although graphene and related materials are two-dimensional (2D) fully conjugated networks, similar covalent organic frameworks (COFs) could offer tailored electronic and magnetic properties. Jin et al. synthesized a fully π-conjugated COF through condensation reactions of tetrakis(4-formyl... | 10.1038/s43586-022-00181-z | This work reports the discovery of ferromagnetism in carbon-conjugated COFs. |
10.1126/science.1120411 | 104,420,153 | Covalent organic frameworks (COFs) have been designed and successfully synthesized by condensation reactions of phenyl diboronic acid {C 6 H 4 [B(OH) 2 ] 2 } and hexahydroxytriphenylene [C 18 H 6 (OH) 6 ]. Powder x-ray diffraction studies of the highly crystalline products (C 3 H 2 BO) 6 ·(C 9 H 12 ) 1 (COF-1) and C 9 ... | 10.1038/s43586-022-00181-z | This work reports the synthesis of the early example of COFs. |
10.1002/anie.201905886 | 18,935,106 | Abstract Two 2D covalent organic frameworks (COFs) linked by vinylene (−CH=CH−) groups (V‐COF‐1 and V‐COF‐2) are synthesized by exploiting the electron deficient nature of the aromatic s ‐triazine unit of C 3 ‐symmetric 2,4,6‐trimethyl‐ s ‐triazine (TMT). The acidic terminal methyl hydrogens of TMT can easily be abstra... | 10.1038/s43586-022-00181-z | This work reports the synthesis of a C=C COF with base conditions. |
10.1126/science.aat7679 | 104,396,743 | The crystallization problem is an outstanding challenge in the chemistry of porous covalent organic frameworks (COFs). Their structural characterization has been limited to modeling and solutions based on powder x-ray or electron diffraction data. Single crystals of COFs amenable to x-ray diffraction characterization h... | 10.1038/s43586-022-00181-z | This work reports a seeded growth strategy to prepare single-crystal 3D COFs 100 μm in size. |
10.1126/science.aar7883 | 41,653,407 | Polymerization of monomers into periodic two-dimensional networks provides structurally precise, layered macromolecular sheets that exhibit desirable mechanical, optoelectronic, and molecular transport properties. Two-dimensional covalent organic frameworks (2D COFs) offer broad monomer scope but are generally isolated... | 10.1038/s43586-022-00181-z | This work reports a seeded growth strategy to prepare single-crystal 2D COFs 1 μm in size. |
10.1038/s41467-019-11921-3 | 61,347,481 | Abstract Engineering conducting polymer thin films with morphological homogeneity and long-range molecular ordering is intriguing to achieve high-performance organic electronics. Polyaniline (PANI) has attracted considerable interest due to its appealing electrical conductivity and diverse chemistry. However, the synth... | 10.1038/s43586-022-00181-z | This work showcases a rare example of COFs as a chemiresistive sensor. |
10.1038/s41467-021-27128-4 | 128,522,585 | Abstract Progress over the past decades in water confinement has generated a variety of polymers and porous materials. However, most studies are based on a preconception that small hydrophobic pores eventually repulse water molecules, which precludes the exploration of hydrophobic microporous materials for water confin... | 10.1038/s43586-022-00181-z | This work showcases water confinement control in the COF channels. |
10.1038/s41534-017-0026-2 | 17,654,806 | Abstract Quantum key distribution provides an efficient means to exchange information in an unconditionally secure way. Historically, quantum key distribution protocols have been based on binary signal formats, such as two polarization states, and the transmitted information efficiency of the quantum key is intrinsical... | 10.1038/s42005-019-0269-7 | High-dimensional quantum key distribution session using multi-core fibers and integrated photonic circuits for the transmitting/receiving modules |
10.1007/s00259-022-05834-5 | 129,835,431 | Abstract Purpose A sensitive and specific imaging method to detect metastatic cancer cells in lymph nodes to detect the early-stage breast cancer is still a challenge. The purpose of this study was to investigate a novel breast cancer–targeting and tumour microenvironment ATP-responsive superparamagnetic iron oxide nan... | 10.1038/s44222-022-00017-1 | This article describes the combination of fluorescence molecular imaging and MPI for the precise and quantitative identification of metastatic lymph nodes without penetration depth limitation |
10.1098/rspa.1949.0075 | 103,839,797 | The subject of this paper is a new two-step method of optical imagery. In a first step the object is illuminated with a coherent monochromatic wave, and the diffraction pattern resulting from the interference of the coherent secondary wave issuing from the object with the strong, coherent background is recorded on a ph... | 10.1038/s43586-022-00165-z | Together with Gabor (1948), this paper demonstrates that it is possible to optically reconstruct a 3D representation of a specimen from its recorded hologram, a finding that launched the field of holographic microscopy |
10.1063/5.0015976 | 80,597,857 | In the past few years, the venerable field of holographic microscopy has been revitalized by computational data analysis. It is now possible to fit a generative (forward) model of scattering directly to experimentally obtained holograms of complex microscopic objects. This approach enables precision measurements: it al... | 10.1038/s43586-022-00165-z | This review highlights the historic development of the generative modelling approach to holograms (the only review to our knowledge that does so) and discusses the current abilities and limitations of existing generative models |
10.1038/ncomms13348 | 41,744,709 | Abstract Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expr... | 10.1038/s43587-022-00350-5 | This paper reports the activation of the cGAS–STING pathway mainly in microglia upon viral infection in the central nervous system. |
10.1038/srep25629 | 89,811,617 | Abstract CD23 has been implicated as a negative regulator of IgE and IgG antibody responses. However, whether CD23 has any role in B-cell activation remains unclear. We examined the expression of CD23 in different subsets of peripheral B cells and the impact of CD23 expression on the early events of B-cell receptor (BC... | 10.1038/s44161-022-00169-8 | This paper reports that CD23 downregulates BCR signaling by influencing actin-mediated clustering of the BCR and B cell morphological changes. |
10.3390/ijms22063091 | 105,721,133 | Non-alcoholic fatty liver disease is recognized as the leading cause of chronic liver disease. Overnutrition and obesity are associated with hepatic steatosis. G protein-coupled receptor 55 (GPR55) has not been extensively studied in hepatic steatosis, although its endogenous ligands have been implicated in liver disea... | 10.1038/s44161-022-00169-8 | This paper reports pro-steatotic effects in hepatocytes stimulated with the synthetic GPR55 agonist O-1602, effects that were reversed by the GPR55 antagonist CID16020046. |
10.1126/science.1170524 | 20,869,495 | Colloidal Nanocrystal Compounds Colloidal nanocrystals have properties that fall between those of the individual atoms but also differ from bulk due to confinement effects. They can thus be thought of as analogs of atoms, and, like atoms, there is a desire to bond together neighboring particles, which will also affect ... | 10.1038/s41928-021-00632-7 | This work explores the utility of molecular metal chalcogenide complexes as surface capping ligands for colloidal nanocrystals and nanowires |
10.1038/s41586-020-1943-3 | 83,488,365 | Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCG... | 10.1038/s43018-022-00512-9 | This landmark paper characterized mutational signatures from 4,645 whole-genome sequences and 19,184 exome sequences that encompass most types of cancer, as part of the Pan-Cancer Analysis of Whole Genomes. |
10.1038/nature25480 | 20,453,390 | Abstract Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and you... | 10.1038/s43018-022-00512-9 | This paper describes one of the largest pan-cancer genomic analyses of pediatric cancer, with information on patterns of genetic alterations and drug targets. |
10.1038/s41467-018-05228-y | 103,690,110 | Abstract Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair pathways are well established to increase lifetime cancer risk. Computational analysis of pan-cancer data has identified signatures of mutational processes thought to be responsible for the pattern of mutations in any give... | 10.1038/s43018-022-00512-9 | This review article presents the therapeutic implications of mutational signatures from DNA repair deficiency in cancer. |
10.1063/1.4990724 | 38,991,707 | Spin waves (SWs) may be used as potential information carriers in next generation low-power spintronics devices. Here, we report an experimental study on the excitation of propagating magnetostatic surface SWs by voltage-controlled magnetic anisotropy in a 2 nm thick CoFeB film. The SWs are detected by a pico-second ti... | 10.1038/s42005-019-0189-6 | First experimental report on spin wave excitation by voltage-controlled magnetic anisotropy and its advantages over Oersted field excitation |
10.1126/science.aaz3985 | 38,448,086 | Subwavelength optical resonators made of high-index dielectric materials provide efficient ways to manipulate light at the nanoscale through mode interferences and enhancement of both electric and magnetic fields. Such Mie-resonant dielectric structures have low absorption, and their functionalities are limited predomi... | 10.1038/s42005-022-00884-5 | High-Q quasi-BIC modes in an individual subwavelength dielectric resonator increased the nonlinear efficiency of second-harmonic generation |
10.1038/s41467-021-24502-0 | 135,369,217 | Abstract Wavelength-scale lasers provide promising applications through low power consumption requiring for optical cavities with increased quality factors. Cavity radiative losses can be suppressed strongly in the regime of optical bound states in the continuum; however, a finite size of the resonator limits the perfo... | 10.1038/s42005-022-00884-5 | A supercavity mode created by merging symmetry-protected and accidental BICs realized a low-threshold laser based on a finite-size cavity |
10.1038/s41467-018-02884-y | 109,410,095 | Abstract The large-scale production of hydrogen from biomass under industrial conditions is fundamental for a sustainable future. Here we present a multiscale study of the available reforming technologies based on a density functional theory open database that allows the formulation of linear scaling relationships and ... | 10.1038/s41929-019-0298-3 | An extensive first-principles-based microkinetic study of alcohol reforming on various transition metals exploring complex reaction networks and generating a valuable open, accessible, interoperable and reusable (FAIR) database |
10.1002/anie.201802113 | 32,883,799 | Abstract Heterogeneous catalysts are often designed as metal nanoparticles supported on oxide surfaces. Here, the relation between particle morphology and reaction kinetics is investigated by scaling relation kinetic Monte Carlo simulations using CO oxidation over Pt nanoparticles as a model reaction. We find that diff... | 10.1038/s41929-019-0298-3 | Constructing kinetic Monte Carlo models on metal nanoparticles allowed addressing structural complexity of metal catalysts and revealed synergistic effects between assemblies of active sites |
10.1038/ncomms7511 | 83,301,251 | Abstract Catalysis by gold supported on reducible oxides has been extensively studied, yet issues such as the nature of the catalytic site and the role of the reducible support remain fiercely debated topics. Here we present ab initio molecular dynamics simulations of an unprecedented dynamic single-atom catalytic mech... | 10.1038/s41929-019-0298-3 | Ab initio molecular dynamics were used to simulate the structural distortions of oxide -supported Au catalysts under reaction conditions, revealing the dynamic formation of highly active single-atom sites |
10.1126/science.aad8132 | 20,600,528 | Inject, baby, inject! Atmospheric CO 2 can be sequestered by injecting it into basaltic rocks, providing a potentially valuable way to undo some of the damage done by fossil fuel burning. Matter et al. injected CO 2 into wells in Iceland that pass through basaltic lavas and hyaloclastites at depths between 400 and 800 ... | 10.1038/s43017-019-0011-8 | Reports on the results from the rapid mineralization of the CarbFix pilot injection |
10.1073/pnas.0805794105 | 104,177,533 | The rate of natural carbonation of tectonically exposed mantle peridotite during weathering and low-temperature alteration can be enhanced to develop a significant sink for atmospheric CO 2 . Natural carbonation of peridotite in the Samail ophiolite, an uplifted slice of oceanic crust and upper mantle in the Sultanate ... | 10.1038/s43017-019-0011-8 | Reviews the carbonation of peridotites and their potential for CO 2 storage |
10.1039/c4cs00035h | 125,279,152 | Mineral carbonation is a promising and at the same time challenging option for the sequestration of anthropogenic CO 2 . | 10.1038/s43017-019-0011-8 | Reviews the potential of in situ and ex situ storage through mineral carbonation |
10.1055/s-0040-1705986 | 122,471,224 | Abstract Transition-metal-catalyzed cross-coupling of organohalides, ethers, sulfides, amines, and alcohols (and derivatives thereof) with Grignard reagents, known as the Kumada–Tamao–Corriu reaction, can be used to prepare important intermediates in the synthesis of numerous biologically active compounds. The most f... | 10.1038/s44160-022-00190-6 | A review article that presents the utility of Grignard reagents in modern organic synthesis. |
10.1177/0022343320984210 | 61,764,000 | The study of security implications of climate change has developed rapidly from a nascent area of academic inquiry into an important and thriving research field that traverses epistemological and disciplinary boundaries. Here, we take stock of scientific progress by benchmarking the latest decade of empirical research ... | 10.1038/s41893-022-00937-1 | A review of the latest progress in climate–conflict research, highlighting priorities, new results and remaining research gaps. |
10.1146/annurev.energy.32.041006.101434 | 81,124,599 | This review examines the state of conflict and cooperation over transboundary water resources from an environmental, political, and human development perspective. Although the potential for outright war between countries over water is low, cooperation is often missing in disputes over transboundary resources. This back... | 10.1038/s41893-022-00937-1 | A review on conflict and cooperation over transboundary water resources. |
10.1038/s41597-020-00612-0 | 41,445,018 | Abstract Accurately assessing green and blue water requirements from croplands is fundamental to promote sustainable water management. In the last decade, global hydrological models have provided important insights into global patterns of water requirements for crop production. As important as these models are, they do... | 10.1038/s41893-022-00937-1 | This paper presents the hydrological model used in our current study and provides the main results of the model. |
10.1126/science.aar3617 | 62,535,159 | Magnetic insulators are a key resource for next-generation spintronic and topological devices. The family of layered metal halides promises varied magnetic states, including ultrathin insulating multiferroics, spin liquids, and ferromagnets, but device-oriented characterization methods are needed to unlock their potent... | 10.1038/s41928-019-0273-7 | This paper reported the experimental demonstration of giant TMR in 2D MTJ |
10.1038/ncomms13372 | 104,308,111 | Abstract Future development in spintronic devices will require an advanced control of spin currents, for example by an electric field. Here we demonstrate an approach that differs from previous proposals such as the Datta and Das modulator, and that is based on a van de Waals heterostructure of atomically thin graphene... | 10.1038/s41928-019-0273-7 | This paper presented an experimental demonstration of a 2D spin logic device |
10.1038/s41467-019-13758-2 | 61,607,707 | Abstract Enzyme biosensors are useful tools that can monitor rapid changes in metabolite levels in real-time. However, current approaches are largely constrained to metabolites within a limited chemical space. With the rising development of artificial metalloenzymes (ArM), a unique opportunity exists to design biosenso... | 10.1038/s41929-021-00673-3 | An artificial metalloenzyme catalysing olefin metathesis to detect ethylene in fruit and leaf cuts |
10.1126/science.1259680 | 107,091,335 | The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing functional, three-dimensional protein structures from first principles. Here we report an artificial metallo-β-lactamase, constructed via the self-assembly of a st... | 10.1038/s41929-021-00673-3 | Design and evolution of an artificial metalloenzyme for the hydrolysis of β-lactams in the periplasm of E. coli through the design of protein interfaces. |
10.1002/anie.202014771 | 67,542,893 | Abstract We report the supramolecular assembly of artificial metalloenzymes (ArMs), based on the Lactococcal multidrug resistance regulator (LmrR) and an exogeneous copper(II)–phenanthroline complex, in the cytoplasm of E. coli cells. A combination of catalysis, cell‐fractionation, and inhibitor experiments, supplement... | 10.1038/s41929-021-00673-3 | Assembly of an artificial metalloenzyme in the cytoplasm of E. coli catalysing Diels–Alder and Friedel–Crafts reactions. |
10.1146/annurev-biodatasci-080917-013525 | 61,722,145 | An interplay of experimental and computational methods is required to achieve a comprehensive understanding of protein–RNA interactions. UV crosslinking and immunoprecipitation (CLIP) identifies endogenous interactions by sequencing RNA fragments that copurify with a selected RNA-binding protein under stringent conditi... | 10.1038/s43586-021-00018-1 | This study reviews computational methods and presents the analysis of RNA splicing maps as a way to assess the sensitivity and specificity of CLIP data |
10.1038/s41586-020-2077-3 | 83,414,608 | Abstract Many proteins regulate the expression of genes by binding to specific regions encoded in the genome 1 . Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the Encyclopedia of DNA Elements (ENCODE) project phase III. This... | 10.1038/s43586-021-00018-1 | This study performs eCLIP experiments for 103 RBPs from HepG2 and 120 RBPs from K562 cell lines, each in duplicate and with SMI controls, and carried out comparative analysis; the data are available as part of the ENCODE project |
10.1101/gr.229757.117 | 39,795,077 | Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3′ splice sites and recruits the spliceosome. We establish “in vitro iCLIP” experiments, in which recombinant RBPs are incubat... | 10.1038/s43586-021-00018-1 | This study describes the development of ‘in vitro iCLIP’ for the study of how protein–RNA interactions are determined by cis -acting sequences and modulated by trans -acting RBPs |
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