source_doi stringlengths 13 57 | source_mag_paper_id int64 490k 157M | source_abstract stringlengths 8 10.7k | target_doi stringlengths 14 27 | target_summary stringlengths 42 889 |
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10.1126/sciadv.1700263 | 125,091,722 | Compound extremely hot and dry summers become more frequent with higher CO 2 concentrations due to stronger interdependence. | 10.1038/s43017-020-0060-z | Reports an increase in the dependence between summer temperature and precipitation with global warming, leading to an elevated risk of extremely hot and dry summers on top of long-term climate trends (multivariate event) |
10.1175/mwr3160.1 | 124,296,215 | Abstract The clustering in time (seriality) of extratropical cyclones is responsible for large cumulative insured losses in western Europe, though surprisingly little scientific attention has been given to this important property. This study investigates and quantifies the seriality of extratropical cyclones in the Nor... | 10.1038/s43017-020-0060-z | Models the serial clustering of extratropical cyclones with a point-process approach and links the strength of clustering with teleconnection indices (temporally compounding) |
10.5194/egusphere-egu2020-20116 | 33,339,327 | <p>The 2016 wheat harvest in France suffered from an unforeseen and unprecedented production loss. At 5.4 tonnes ha<sup>-1</sup>, wheat yield was the lowest recorded since 1986 and 30% below the five-year average.  Crop yield forecasting can be considered as near-r... | 10.1038/s43017-020-0060-z | Reveals the drivers of the 2016 extreme wheat loss in France as a combination of unusually warm temperatures in late autumn and unusually wet conditions in the following spring (temporally compounding) |
10.1002/2015wr018525 | 79,916,096 | Abstract A time‐varying risk analysis is proposed for an adaptive design framework in nonstationary conditions arising from climate change. A Bayesian, dynamic conditional copula is developed for modeling the time‐varying dependence structure between mixed continuous and discrete multiattributes of multidimensional hyd... | 10.1038/s43017-020-0060-z | Introduces an approach to model multivariate events in a non-stationary environment with copulas |
10.1002/anie.201205449 | 20,453,650 | Abstract Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis. This review describes developments in the burgeoning field... | 10.1038/s44160-022-00143-z | A review article that presents an overview of asymmetric ion-pairing catalysis. |
10.1038/s41467-017-01061-x | 101,068,181 | Abstract The quantum Rabi model describing the fundamental interaction between light and matter is a cornerstone of quantum physics. It predicts exotic phenomena like quantum phase transitions and ground-state entanglement in ultrastrong and deep-strong coupling regimes, where coupling strengths are comparable to or la... | 10.1038/s42254-018-0006-2 | Experimental quantum simulation of the quantum Rabi model, demonstrating photonic Schrödinger’s cat states in the ground state of that model |
10.1126/science.abb2986 | 41,664,201 | The mammalian heart is derived from multiple cell lineages; however, our understanding of when and how the diverse cardiac cell types arise is limited. We mapped the origin of the embryonic mouse heart at single-cell resolution using a combination of transcriptomic, imaging, and genetic lineage labeling approaches. Thi... | 10.1038/s44161-022-00078-w | This study reports a detailed and spatially mapped single-cell analysis of the developing mouse heart |
10.1038/s41467-020-20615-0 | 83,531,121 | Abstract The active sites for CO 2 electroreduction (CO 2 R) to multi-carbon (C 2+ ) products over oxide-derived copper (OD-Cu) catalysts are under long-term intense debate. This paper describes the atomic structure motifs for product-specific active sites on OD-Cu catalysts in CO 2 R. Herein, we describe realistic OD-... | 10.1038/s41929-023-00911-w | Identifies active sites for C–C coupling by machine learning molecular dynamics simulations of reduction processes of oxide-derived copper catalysts |
10.1038/ncomms14621 | 20,431,660 | Abstract Surface reaction networks involving hydrocarbons exhibit enormous complexity with thousands of species and reactions for all but the very simplest of chemistries. We present a framework for optimization under uncertainty for heterogeneous catalysis reaction networks using surrogate models that are trained on t... | 10.1038/s41929-023-00911-w | Identifies the most likely reaction pathway for syngas conversion on Rh(111) from a multitude of pathways with machine learning |
10.1126/science.aaw3913 | 20,859,800 | The opening of epoxides typically requires electrophilic activation, and subsequent nucleophilic (S N 2) attack on the less substituted carbon leads to alcohols with Markovnikov regioselectivity. We describe a cooperative catalysis approach to anti-Markovnikov alcohols by combining titanocene-catalyzed epoxide opening ... | 10.1038/s44160-022-00047-y | This paper reports the ring opening of epoxides through cooperative catalysis |
10.1002/anie.200603224 | 62,550,019 | Abstract Complexes in which a σ‐HE bond (E=H, B, Si, C) acts as a two‐electron donor to the metal center are called σ complexes. Clues that it is possible to interconvert σ ligands without a change in oxidation state derive from CH activation reactions effecting isotope exchange and from dynamic rearrangements of σ c... | 10.1038/s42004-021-00611-1 | This paper outlines the σ-complex assisted metathesis mechanism and the differences from the traditional sigma bond metathesis mechanism |
10.5194/acp-17-5601-2017 | 59,724,054 | Abstract. The importance of wind-blown mineral dust for cloud droplet formation is studied by considering (i) the adsorption of water on the surface of insoluble particles, (ii) particle coating by soluble material (atmospheric aging) which augments cloud condensation nuclei (CCN) activity, and (iii) the effect of dust... | 10.1038/s43017-022-00379-5 | This article investigates the different mechanisms by which dust particles affect warm clouds, finding that dust increases cloud droplet number concentrations over deserts but decreases it over polluted regions. |
10.5194/acp-19-7397-2019 | 41,311,577 | Abstract. The chemical ageing of aeolian dust, through interactions with air pollution, affects the optical and hygroscopic properties of the mineral particles and hence their atmospheric residence time and climate forcing. Conversely, the chemical composition of the dust particles and their role as coagulation partner... | 10.1038/s43017-022-00379-5 | This article uses a chemistry–climate model to shed light on the climatic effects of the interactions between dust and anthropogenic air pollution. |
10.1029/2005jd006977 | 62,601,037 | Coating of mineral dust particles by air pollutants leads to core‐mantle particles. These composite aerosols could interact differently with atmospheric radiation than the uncoated dust. In our simplified radiative calculations we assumed that a spherical dust core is covered uniformly by a liquid refractive material, ... | 10.1038/s43017-022-00379-5 | This article provides a first attempt to evaluate the effects of dust coating by sulfate and nitrate on the aerosol direct radiative effect. |
10.5194/acp-21-6875-2021 | 76,602,808 | Abstract. Black carbon (BC), brown carbon (BrC), and soil dust are the most important radiation-absorbing aerosols (RAAs). When RAAs are deposited on the snowpack, they lower the snow albedo, causing an increase in the solar radiation absorption. The climatic impact associated with the snow darkening induced by RAAs is... | 10.1038/s43017-022-00379-5 | This article provides an observationally constrained estimate of the global mean dust-snow radiative effect with a comprehensive uncertainty analysis. |
10.1029/2019jd031807 | 38,228,850 | Abstract Airborne mineral dust influences cloud occurrence and optical properties, which may provide a pathway for recent and future changes in dust concentration to alter the temperature at Earth's surface. However, despite prior suggestions that dust‐cloud interactions are an important control on the Earth's radiatio... | 10.1038/s43017-022-00379-5 | This global modelling study of the various dust radiative effects on clouds finds that many of the interactions produce counteracting radiative effects. |
10.5194/acp-19-15503-2019 | 81,811,603 | Abstract. The optical properties of airborne mineral dust depend on its mineralogy, size distribution, and shape, and they might vary between different source regions. To date, large differences in refractive index values found in the literature have not been fully explained. In this paper we present a new dataset of c... | 10.1038/s43017-022-00379-5 | This article used laboratory experiments to obtain the shortwave optical properties of aerosols generated from desert soil samples across the world, finding that dust in climate models might be too absorbing. |
10.1126/science.288.5468.1042 | 125,164,038 | Measurements and models show that enhanced aerosol concentrations can augment cloud albedo not only by increasing total droplet cross-sectional area, but also by reducing precipitation and thereby increasing cloud water content and cloud coverage. Aerosol pollution is expected to exert a net cooling influence on the gl... | 10.1038/s43017-022-00379-5 | This article shows that absorbing aerosols within a cloud layer can reduce cloudiness. |
10.5194/acp-21-665-2021 | 122,946,940 | Abstract. Shallow clouds covering vast areas of the world's middle- and high-latitude oceans play a key role in dampening the global temperature rise associated with CO2. These clouds, which contain both ice and supercooled water, respond to a warming world by transitioning to a state with more liquid water and a great... | 10.1038/s43017-022-00379-5 | This article highlights the importance of understanding present and future emissions of dust and other ice nucleating particles for determining the cloud-phase climate feedback that partially controls climate sensitivity. |
10.5194/acp-22-2095-2022 | 136,317,214 | Abstract. Mineral dust impacts key processes in the Earth system, including the radiation budget, clouds, and nutrient cycles. We evaluate dust aerosols in 16 models participating in the sixth phase of the Coupled Model Intercomparison Project (CMIP6) against multiple reanalyses and observations. We note that both the ... | 10.1038/s43017-022-00379-5 | This article shows that many of the biases reported for simulated dust in CMIP5 climate models still exist in the more recent CMIP6 models and implies that, as model complexity grows, so does the intermodel spread in simulated dust. |
10.1038/s41467-017-02620-y | 81,927,127 | Abstract Feedbacks between the global dust cycle and the climate system might have amplified past climate changes. Yet, it remains unclear what role the dust–climate feedback will play in future anthropogenic climate change. Here, we estimate the direct dust–climate feedback, arising from changes in the dust direct rad... | 10.1038/s43017-022-00379-5 | This article estimates the dust-climate feedback on global and regional scales using models and observations. |
10.1073/pnas.0608803103 | 104,397,310 | Painting a glass slide with branched or linear N , N -dodecyl methyl-polyethylenimines (PEIs) and certain other hydrophobic PEI derivatives enables it to kill influenza virus with essentially a 100% efficiency (at least a 4-log reduction in the viral titer) within minutes, as well as the airborne human pathogenic bacte... | 10.1038/s43246-021-00153-y | Shows how PEI painted (coated) surfaces, in addition to being extremely bactericidal, reduce the amount of influenza A and shows the relationship between the viricidal activity and the coating polymer structure |
10.1002/smll.201904756 | 17,740,852 | Abstract Graphene coatings composed of vertical spikes are shown to mitigate bacterial attachment. Such coatings present hydrophobic edges of graphene, which penetrate the lipid bilayers causing physical disruption of bacterial cells. However, manufacturing of such surfaces on a scale required for antibacterial applica... | 10.1038/s43246-021-00153-y | Shows how graphite nanoplatelets can be used as a cheap and practical way of improving the antibacterial properties of polymer surfaces |
10.1126/sciadv.aar5931 | 122,984,816 | Daylight-driven antimicrobial nanomaterials serve as a novel barrier for transmission of emerging infectious diseases. | 10.1038/s43246-021-00153-y | Shows that the green bioprotective nanofibrous membranes (RNMs) with rechargeable antibacterial and antiviral activities can be incorporated into protective equipment to achieve robust bio-protection against pathogens either in aerosol or in liquid forms |
10.1098/rstb.2007.2166 | 41,509,109 | As a result of agricultural intensification, more food is produced today than needed to feed the entire world population and at prices that have never been so low. Yet despite this success and the impact of globalization and increasing world trade in agriculture, there remain large, persistent and, in some cases, worse... | 10.1038/s41893-018-0155-4 | A comprehensive review of the current challenges and options for improving global agricultural policy, including overcoming problems of land degradation |
10.1017/s1355770x1000032x | 123,301,784 | ABSTRACT This paper examines the complex relationship that exists between poverty and natural resource degradation in developing countries. The rural poor are often concentrated in fragile, or less favorable, environmental areas. Consequently, their livelihoods can be intimately dependent on natural resource use and ec... | 10.1038/s41893-018-0155-4 | Highlights the causes and consequences of a potential poverty–environment ‘downward spiral’; consistently one of the most read articles in Environment and Development Economics |
10.1146/annurev-resource-100815-095521 | 122,517,042 | The natural resource base, terrestrial and marine, provides rural households in lower-income countries with income, food, shelter, and medicines, which are variously gathered and hunted in common lands and waters. These resources may be actively managed, either by the government or local community; or they may be de fa... | 10.1038/s41893-018-0155-4 | A comprehensive review of the empirical evidence of how poor rural households depend on the surrounding natural environment |
10.1038/s41467-019-14113-1 | 62,248,803 | Abstract Porphyry deposits are natural suppliers of most copper and significant gold to our society. Whereas the Cu-richest (Au-poor) porphyries are related to Andean-type subduction and typical calc-alkaline magmatism, the Au-richest porphyries are associated with high-K calc-alkaline to alkaline magmatism in late to ... | 10.1038/s43017-021-00182-8 | Revealed different Au precipitation efficiencies between Au-rich and Au-poor porphyry Cu deposits and suggested a link between emplacement depth and Au endowment |
10.1038/srep44523 | 125,061,883 | Abstract Porphyry deposits, our main source of copper and of significant amounts of Mo, Re and Au, form at convergent margins in association with intermediate-felsic magmas. Although it is accepted that copper is transported and precipitated by fluids released by these magmas, the magmatic processes leading to the form... | 10.1038/s43017-021-00182-8 | Revealed the importance of prolonged magma accumulation and evolution in the lower crustal reservoir, generating large amounts of hydrous andesitic magma that contains enough water to deliver large amounts of Cu and Au in porphyry deposits |
10.1126/science.aah5237 | 62,306,756 | Optimizing designer metabolisms in vitro Biological carbon fixation requires several enzymes to turn CO 2 into biomass. Although this pathway evolved in plants, algae, and microorganisms over billions of years, many reactions and enzymes could aid in the production of desired chemical products instead of biomass. Schwa... | 10.1038/s41929-019-0421-5 | This work illustrates how the design and construction of a synthetic CO 2 fixation pathway that is in vitro much faster than the CBB cycle in cell extracts |
10.1126/sciadv.abh0952 | 134,503,037 | We constructed a large optical computer based on optical parametric oscillators coupled via measurement and feedback. | 10.1038/s41928-022-00752-8 | This paper reports a coherent Ising machine utilizing an optical fibre and field-programmable gate array chips |
10.1121/1.400907 | 42,558,917 | A stable force potential well was generated by two collimated focused ultrasonic (3.5 MHz) beams propagating along opposite directions. Latex particles (270-μm diameter) and clusters of frog eggs were trapped in the potential well. The trapped object can be moved axially or laterally by moving one of the PZT focusing t... | 10.1038/s43586-022-00109-7 | This study presents the first demonstration of 3D particle trapping and movement using standing acoustic waves and is the namesake for acoustical tweezers |
10.1038/s41467-020-18000-y | 20,110,323 | Abstract Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equ... | 10.1038/s43586-022-00109-7 | This study demonstrates the selective manipulation of individual cells within a microfluidic chamber using acoustic vortices |
10.1073/pnas.1209288109 | 41,483,620 | Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based “acoustic tweezers” that can trap and manipulate single microparticles, cells, and entire orga... | 10.1038/s43586-022-00109-7 | This study demonstrates an acoustic manipulation method to precisely control a single microparticle, cell or organism along an arbitrary path in two dimensions |
10.1038/s41467-018-07823-5 | 41,542,798 | Abstract The fabrication of functional tissues is essential for clinical applications such as disease treatment and drug discovery. Recent studies have revealed that the mechanical environments of tissues, determined by geometric cell patterns, material composition, or mechanical properties, play critical roles in ensu... | 10.1038/s43586-022-00109-7 | This article demonstrates how acoustofluidic technologies can be used in practical tissue engineering applications by creating artificial tissues with acoustically aligned cells and implanting them into a mouse model |
10.1002/mp.13839 | 81,698,987 | Thermoluminescent dosimeters (TLD) and optically stimulated luminescent dosimeters (OSLD) are practical, accurate, and precise tools for point dosimetry in medical physics applications. The charges of Task Group 191 were to detail the methodologies for practical and optimal luminescence dosimetry in a clinical setting.... | 10.1038/s43586-022-00102-0 | Important report from a task group of the American Associations of Physicists in Medicine on medical use of thermoluminescence and optically stimulated luminescent dosimeters |
10.1111/nyas.14337 | 104,155,179 | Abstract Globally, thermodynamics explains an increase in atmospheric water vapor with warming of around 7%/°C near to the surface. In contrast, global precipitation and evaporation are constrained by the Earth's energy balance to increase at ∼2–3%/°C. However, this rate of increase is suppressed by rapid atmospheric a... | 10.1038/s43017-021-00181-9 | Addresses the challenges in better understanding the sensitivity of the water cycle to climate change. |
10.1146/annurev-clinpsy-081219-092850 | 121,864,287 | Empirical publications inspired by the network approach to psychopathology have increased exponentially in the twenty-first century. The central idea that an episode of mental disorder arises from causal interactions among its symptomatic elements has especially resonated with those clinical scientists whose disenchant... | 10.1038/s43586-021-00055-w | This paper is a state-of-the-art overview of the status of network analysis in psychopathology |
10.31234/osf.io/km37w | 41,045,235 | The network theory of psychopathology posits that mental disorders are complex systems of mutually reinforcing symptoms. This overarching framework has proven highly generative but does not specify precisely how any specific mental disorder operates as such a system. We address this gap in the literature by developing ... | 10.1038/s43586-021-00055-w | This article is the first to augment symptom network models with substantively plausible formalized theory |
10.1002/ehf2.12003 | 83,267,688 | Abstract Large and growing body of data suggest that an increased late sodium current (I Na,late ) can have a significant pathophysiological role in heart failure and other heart diseases. The first goal of this article is to describe how I Na,late functions under physiological circumstances. The second goal is to show... | 10.1038/s44161-022-00077-x | A review article that presents recent advances in understanding of the role of I Na,L |
10.1126/sciadv.abc5491 | 103,649,453 | The earliest evidence for subduction, which could have been localized, does not signify when plate tectonics became a global phenomenon. To test the antiquity of global subduction, we investigated Paleoproterozoic time, for which seismic evidence is available from multiple continents. We used a new high-density seismic... | 10.1038/s43017-021-00160-0 | Reports the first global-scale evidence for subduction using seismic images from multiple continents, arguing for the onset of the global plate tectonic network by ca. 2 Ga |
10.1073/pnas.1608824114 | 18,898,269 | The first significant buildup in atmospheric oxygen, the Great Oxidation Event (GOE), began in the early Paleoproterozoic in association with global glaciations and continued until the end of the Lomagundi carbon isotope excursion ca. 2,060 Ma. The exact timing of and relationships among these events are debated becaus... | 10.1038/s43017-021-00160-0 | Offers a combined geologic and palaeomagnetic reconstruction of supercraton Superia and its context in low-latitude glaciation and the Great Oxidation Event |
10.1093/ageing/afaa207 | 20,465,550 | Abstract Background mortality in care homes has had a prominent focus during the COVID-19 outbreak. Care homes are particularly vulnerable to the spread of infectious diseases, which may lead to increased mortality risk. Multiple and interconnected challenges face the care home sector in the prevention and management o... | 10.1038/s43587-022-00235-7 | This paper compares mortality rates between 2016–2019 and 2020 from care home residents |
10.1093/ageing/afab060 | 61,383,212 | Abstract Background epidemiological data on COVID-19 infection in care homes are scarce. We analysed data from a large provider of long-term care for older people to investigate infection and mortality during the first wave of the pandemic. Methods cohort study of 179 UK care homes with 9,339 residents and 11,604 staff... | 10.1038/s43587-022-00235-7 | This paper reports the morality rates in care home residents who tested positive for SARS-CoV-2 |
10.1093/gerona/glaa183 | 83,386,263 | Abstract Background Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general older population) is unclear. We estimated associations between preexisting diagnoses and ... | 10.1038/s43587-022-00235-7 | This paper looks at pre-existing comorbidities and risk factors for predicting severe COVID-19 in older adults |
10.1186/s12916-021-01945-2 | 82,970,781 | Abstract Background To estimate excess mortality for care home residents during the COVID-19 pandemic in England, exploring associations with care home characteristics. Methods Daily number of deaths in all residential and nursing homes in England notified to the Care Quality Commission (CQC) from 1 January 2017 to 7 A... | 10.1038/s43587-022-00235-7 | This paper looks at excess mortality amongst care home residents during the COVID-19 pandemic in England |
10.1002/chem.201803074 | 60,967,014 | Abstract In the last decade, visible‐light photoredox catalysis has emerged as a powerful strategy to enable novel transformations in organic synthesis. Owing to mild reaction conditions (i.e., room temperature, use of visible light) and high functional‐group tolerance, photoredox catalysis could represent an ideal str... | 10.1038/s42004-020-00413-x | Reference 28 described the recent significant methods for achieving the photoredox modification of peptides and proteins |
10.5194/cp-4-153-2008 | 104,271,969 | Abstract. The global climate system experienced a series of drastic changes during the Cenozoic. In Asia, these include the climate transformation from a zonal pattern to a monsoon-dominated pattern, the disappearance of typical subtropical aridity, and the onset of inland deserts. Despite major advances in the last tw... | 10.1038/s43017-022-00331-7 | This work illustrates changes in the spatial patterns of the East Asian Monsoon and concludes that a major change in the environmental pattern of Asia occurred near the Oligocene–Miocene boundary |
10.5194/cp-16-847-2020 | 55,397,700 | Abstract. The Cenozoic inception and development of the Asian monsoons remain unclear and have generated much debate, as several hypotheses regarding circulation patterns at work in Asia during the Eocene have been proposed in the few last decades. These include (a) the existence of modern-like monsoons since the early... | 10.1038/s43017-022-00331-7 | This model suggests that a zonal arid climate prevailed over Asia before the initiation of monsoons that most likely occurred following Eocene palaeogeographic changes |
10.1126/sciadv.abb8227 | 125,167,653 | The origins and development of the arid and highly seasonal steppe-desert biome in Central Asia, the largest of its kind in the world, remain largely unconstrained by existing records. It is unclear how Cenozoic climatic, geological, and biological forces, acting at diverse spatial and temporal scales, shaped Central A... | 10.1038/s43017-022-00331-7 | This work shows that Central Asian steppe desert has existed since at least Eocene times but has experienced no less than two regime shifts, one at the Eocene–Oligocene transition and one in the middle Miocene |
10.1016/j.yqres.2014.01.002 | 62,514,717 | Abstract The way in which the NE Tibetan Plateau uplifted and its impact on climatic change are crucial to understanding the evolution of the Tibetan Plateau and the development of the present geomorphology and climate of Central and East Asia. This paper is not a comprehensive review of current thinking but instead sy... | 10.1038/s43017-022-00331-7 | This work describes a persistent stepwise accelerated enhancement of the East Asian Winter Monsoon and drying of the Asian interior coupled with tectonic uplifts since ~8 Ma and later also with global cooling |
10.1038/s41467-020-20213-0 | 19,436,354 | Abstract Advances in deep learning technology have enabled complex task solutions. The accuracy of image classification tasks has improved owing to the establishment of convolutional neural networks (CNN). Cellular senescence is a hallmark of ageing and is important for the pathogenesis of ageing-related diseases. Furt... | 10.1038/s43587-022-00265-1 | This paper shows that deep learning can detect senescence in cell culture. |
10.1111/j.1467-7652.2009.00496.x | 83,483,875 | Summary During the last decade, the spectre of an influenza pandemic of avian origin has led to a revision of national and global pandemic preparedness plans and has stressed the need for more efficient influenza vaccines and manufacturing practices. The 2009 A/H1N1 (swine flu) outbreak has further emphasized the neces... | 10.1038/s44222-023-00044-6 | This article reports that plants are able to form virus-like particles upon delivery of human viral membrane-bound proteins. |
10.1111/j.1467-7652.2009.00434.x | 38,297,386 | Summary Agro‐infiltration of leaf tissue with binary vectors harbouring a sequence of interest is a rapid method of expressing proteins in plants. It has recently been shown that flanking the sequence to be expressed with a modified 5′‐untranslated region (UTR) and the 3′‐UTR from Cowpea mosaic virus (CPMV) RNA‐2 (CPMV... | 10.1038/s44222-023-00044-6 | This review provides a comprehensive discussion of CPMV-based expression vectors. |
10.1073/pnas.0400149101 | 20,473,332 | We have developed an efficient, versatile, and user-friendly viral engineering and expression system that is based on in planta assembly of functional viral vectors from separate pro-vector modules. With this new system, instead of supplying a plant cell with a complete viral vector as a mature viral particle, an RNA o... | 10.1038/s44222-023-00044-6 | This article describes the power of viral-based transient expression modules. |
10.1073/pnas.1320544111 | 122,320,598 | Significance IgM antibodies are increasingly gaining interest as therapeutics; however, knowledge about this antibody class is scarce. Specifically the impact of N-glycans on the functional mechanism of this heavily glycosylated molecule is entirely unknown. To address this issue we produced different IgM glycoforms in... | 10.1038/s44222-023-00044-6 | This article demonstrates the plant-based expression of human pentameric IgMs with an engineered glycosylation profile, requiring the simultaneous expression of up to 14 foreign genes in a single plant cell. |
10.1073/pnas.1108360108 | 41,711,583 | No countermeasures currently exist for the prevention or treatment of the severe sequelae of Filovirus (such as Ebola virus; EBOV) infection. To overcome this limitation in our biodefense preparedness, we have designed monoclonal antibodies (mAbs) which could be used in humans as immunoprotectants for EBOV, starting wi... | 10.1038/s44222-023-00044-6 | This article reports the rapid production and delivery of engineered monoclonal antibodies during the Ebola outbreak in West Africa in 2014. |
10.1073/pnas.2107249118 | 127,321,281 | Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed at an unprecedented speed. Notwithstanding, there is a vague understanding of the various Ab functions induced beyond antigen binding by the heavy-chain constant domain. To explore the diverse roles of Abs in SARS-CoV-2 immunity, we... | 10.1038/s44222-023-00044-6 | This article reports the expression and functional analysis of IgG3. |
10.1111/pbi.12981 | 124,171,414 | Summary Plants offer fast, flexible and easily scalable alternative platforms for the production of pharmaceutical proteins, but differences between plant and mammalian N‐linked glycans, including the presence of β‐1,2‐xylose and core α‐1,3‐fucose residues in plants, can affect the activity, potency and immunogenicity ... | 10.1038/s44222-023-00044-6 | This article reports genome editing to manipulate post-translational modifications of proteins in plants. |
10.1038/s41591-021-01370-1 | 62,635,061 | Abstract Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations. Here we report Day 42 interim safety and immunogenicity data from an observer-blinded, dose es... | 10.1038/s44222-023-00044-6 | This article reports the results of a phase I clinical trial of a plant-produced SARS-CoV-2 vaccine. |
10.1111/pbi.12416 | 104,310,488 | Summary Although plant biotechnology has been widely investigated for the production of clinical‐grade monoclonal antibodies, no antibody products derived from transgenic plants have yet been approved by pharmaceutical regulators for clinical testing. In the Pharma‐Planta project, the HIV‐neutralizing human monoclonal ... | 10.1038/s44222-023-00044-6 | This article reports the first-in-human phase I clinical trial of a plant-produced monoclonal antibody. |
10.1002/elan.201000465 | 61,998,271 | Abstract This review presents and promotes preprocessing methods applied in electrochemistry prior to data exploration, calibration and classification. Smoothing by digital filtering, baseline correction, separation of overlapping signals, and also transformations to extract the relevant features of the curve are the a... | 10.1038/s43586-022-00143-5 | This work presents a comprehensive review of data evaluation methods in electrochemistry |
10.2174/157341108784911415 | 87,853,672 | The ability of nucleic acids (NA) and their components to accumulate at electrode surfaces and electrochemical properties of these species are closely related. This review is devoted to electrochemical stripping techniques applied in NA studies. Cathodic or anodic stripping voltammetry have been used for a highly sensi... | 10.1038/s43586-022-00143-5 | This work is a direct analysis of nucleic acids using ESA |
10.1152/ajpheart.00138.2005 | 82,777,573 | Assessment of left ventricular systolic and diastolic pump properties is fundamental to advancing the understanding of cardiovascular pathophysiology and therapeutics, especially for heart failure. The use of end-systolic and end-diastolic pressure-volume relationships derived from measurements of instantaneous left ve... | 10.1038/s44161-021-00007-3 | This review paper is a reference for the physiological concepts involving ventricular properties via pressure–volume analysis |
10.1113/jphysiol.2011.218271 | 62,624,950 | Key points Healthy sedentary ageing leads to stiffening of the heart; however, when this process occurs during ageing has been unknown. In this study, 70 healthy sedentary subjects were stratified into four groups: ‘young’– G 21−34 : 21–34 years; ‘early middle‐age’– G 35−49 : 35–49 years; ‘late middle‐age’– G 50−64 : 5... | 10.1038/s44161-021-00007-3 | This paper provided important results on the physiological aging of ventricular compliance |
10.1126/science.1188119 | 80,570,308 | Writing Conductive Lines with Hot Tips The interface within devices between conductors, semiconductors, and insulators is usually created by stacking patterned layers of different materials. For flexible electronics, it can be advantageous to avoid this architectural constraint. Graphene oxide, formed by chemical exfol... | 10.1038/s43586-022-00110-0 | This study demonstrates the use of tSPL for directly patterning nanometric conductive regions in insulating GO via thermochemical reduction |
10.1002/adfm.200901057 | 123,983,906 | Abstract Nanoscale chemical patterning of different chemical species (amine, thiol, aldehyde, and biotin) in independent nanopatterns is achieved by the iterative application of thermochemical nanolithography (TCNL) to inscribe amine patterns followed by their chemical conversion to other functional groups. Due to the ... | 10.1038/s43586-022-00110-0 | This study demonstrates the use of tSPL for nanopatterning different chemical species in independent nanopatterns |
10.1038/s41467-020-17241-1 | 20,810,922 | Abstract Understanding the atomistic origin of defects in two-dimensional transition metal dichalcogenides, their impact on the electronic properties, and how to control them is critical for future electronics and optoelectronics. Here, we demonstrate the integration of thermochemical scanning probe lithography (tc-SPL... | 10.1038/s43586-022-00110-0 | This study uses tSPL to directly create defects in 2D materials and control the electronic doping for fabricating electronic devices |
10.1126/sciadv.aay0414 | 125,086,162 | For semicrystalline poly(3,4-ethylene dioxythiophene) (PEDOT), oxidative chemical vapor deposition (oCVD) enables systematic control over the b -axis lattice parameter (π-π stacking distance). Decreasing the b -axis lattice parameter increases the charge transfer integral, thus enhancing intracrystallite mobility. To r... | 10.1038/s42254-020-0192-6 | Systematic tuning of the β-axis lattice parameter from 0.702 nm down to 0.697 nm, corresponded in 5,600% increase in electrical conductivity of face-on oriented semicrystalline thin films of oxidative CVD (oCVD) poly(3,4-ethylenedioxythiophene) (PEDOT) |
10.1039/c9me00087a | 58,721,770 | Deposition of materials onto liquid substrates provides complexity due to surface tension, viscosity, and solubility effects. | 10.1038/s42254-020-0192-6 | Provides synthetic guidelines for producing organic and hybrid organic/inorganic particles, films and gels using initiated CVD (iCVD) onto silicone oils and ionic liquids |
10.1002/aelm.201800688 | 41,582,193 | Abstract With the advent of artificial intelligence and the Internet of Things, demand has grown for flexible, low‐power, high‐density nonvolatile memory capable of handling vast amounts of information. Ultrathin‐layered 2D semiconductor materials such as molybdenum disulfide (MoS 2 ) have considerable potential for fl... | 10.1038/s42254-020-0192-6 | Ultrathin, ultrasmooth and flexible high- κ dielectrics ( κ ≈ 6.2) form from the initiated CVD (iCVD) copolymerization of the monomer 2-cyanoethyl acrylate and the di(ethylene glycol) divinyl ether |
10.1038/s41598-018-38390-w | 96,365,461 | Abstract Bulk polytetrafluoroethylene (PTFE) possesses excellent chemical stability and dielectric properties. Indeed, thin films with these same characteristics would be ideal for electret applications. Previously, the electret properties of PTFE-like thin films produced by rf sputtering or plasma enhanced chemical va... | 10.1038/s42254-020-0192-6 | Mechanical-flexible, triboelectric energy harvesters compatible with wearable electronics are demonstrated using initiated CVD (iCVD) fluoropolymer films ranging from 0.5 μm to 12 μm in thickness |
10.1038/s41598-018-24238-w | 55,254,992 | Abstract Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition ... | 10.1038/s42254-020-0192-6 | Systematic increase in the mesh size from 0.15 nm to 3.1 nm for iCVD hydrogels utilized as layers for controlling the release of drugs. |
10.1126/science.1191035 | 104,259,708 | Environment Matters Stem cells isolated from muscle can be used for muscle regeneration, but only if the stem cells are fresh. Under standard cell culture conditions in the laboratory, muscle stem cells fail to proliferate efficiently and lose their regenerative capacity. Gilbert et al. (p. 1078 , published online 15 J... | 10.1038/s43586-022-00179-7 | This article reports that culturing muscle satellite cells on 2D PEG hydrogels that match the stiffness of native muscle preserves their capacity for self-renewal and to contribute to muscle regeneration. |
10.1002/adma.202008111 | 135,167,594 | Abstract The extracellular matrix (ECM) forms through hierarchical assembly of small and larger polymeric molecules into a transient, hydrogel‐like fibrous network that provides mechanical support and biochemical cues to cells. Synthetic, fibrous supramolecular networks formed via non‐covalent assembly of various molec... | 10.1038/s43586-022-00179-7 | This article describes supramocular hydrogels based on the ureido-pyrimidinone motif with tunable mechanical, dynamic and bioactive properties for cell and spheroid encapsulation. |
10.1002/anie.201705684 | 107,258,963 | Abstract The relationship between ECM mechanics and cell behavior is dynamic, as cells remodel and respond to changes in their local environment. Most in vitro substrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible mechanical changes are needed. Herein, we developed hyaluronic... | 10.1038/s43586-022-00179-7 | This articles describes hyaluronic acid-based hydrogels with reversible mechanical properties that rely on photodegradation and photopolymerization strategies. |
10.1002/adma.201807359 | 62,352,850 | Abstract T cell therapies require the removal and culture of T cells ex vivo to expand several thousand‐fold. However, these cells often lose the phenotype and cytotoxic functionality for mediating effective therapeutic responses. The extracellular matrix (ECM) has been used to preserve and augment cell phenotype; howe... | 10.1038/s43586-022-00179-7 | This article shows that the biophysical properties of engineered HA hydrogels potentiate T cell stimulation, which can be harnessed for adoptive immunotherapy. |
10.1073/pnas.1704543115 | 80,108,453 | Although mechanisms of cell–material interaction and cellular mechanotransduction are increasingly understood, the mechanical insensitivity of mesenchymal cells to certain soft amorphous biomaterial substrates has remained largely unexplained. We reveal that surface energy-driven supramolecular ligand assembly can regu... | 10.1038/s43586-022-00179-7 | This study shows that cell mechanotransduction and fate depend heavily on hydrogel hydrophilicity and the conformation of secreted matrix proteins. |
10.1515/pac-2018-1111 | 2,602,217 | Abstract In this paper, we highlight some addition/cycloaddition reactions of allenylphosphonates and allenylphosphine oxides, mostly based on the work done in our laboratory. Thus the electrophilic addition of iodine monochloride (ICl) with allenylphosphine oxides affords cyclic phosphonium salts rather than γ-chloro-... | 10.1038/s44160-022-00127-z | This paper highlights addition and cycloaddition reactions of allenylphosphonates or allenylphosphine oxides. |
10.1126/science.aaf5039 | 41,677,494 | Artificial photosynthesis steps up Photosynthesis fixes CO 2 from the air by using sunlight. Industrial mimics of photosynthesis seek to convert CO 2 directly into biomass, fuels, or other useful products. Improving on a previous artificial photosynthesis design, Liu et al. combined the hydrogen-oxidizing bacterium Rai... | 10.1038/s41929-020-0428-y | The authors present a highly energy efficient device consisting of self regenerating non toxic electrodes and CO 2 fixing bacteria for production of bioplastics and biofuels |
10.1126/science.aad3317 | 125,081,095 | Using light in the darkness Solid-state devices can efficiently capture solar energy to produce chemicals and fuels from carbon dioxide. Yet biology has already developed a high-specificity, low-cost system to do just that through photosynthesis. Sakimoto et al. developed a biological-inorganic hybrid that combines the... | 10.1038/s41929-020-0428-y | This work illustrates the concept of membrane bound self precipitated quantum dots to power CO 2 fixation of live whole cell biocatalysts |
10.1126/sciadv.aap9253 | 104,265,222 | A bioinorganic hybrid system based on bacterial surface display and biomimetic silicification for hydrogen production. | 10.1038/s41929-020-0428-y | The authors illustrate the use of cadmium sulfide quantum dots to provide hydrogenase within E. coli with reducing equivalents for H 2 production |
10.1126/science.aat9777 | 83,398,607 | Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic hybrid platform that consists of highly ... | 10.1038/s41929-020-0428-y | In this study genetically modified yeast were enhanced with light active indium phosphide nanoparticles in order to improve the production of shikimic acid |
10.1073/pnas.1610554113 | 83,398,408 | The rise of inorganic–biological hybrid organisms for solar-to-chemical production has spurred mechanistic investigations into the dynamics of the biotic–abiotic interface to drive the development of next-generation systems. The model system, Moorella thermoacetica –cadmium sulfide (CdS), combines an inorganic semicond... | 10.1038/s41929-020-0428-y | Determined that photosensitized bacteria exhibit spectroscopic changes that allow the authors to propose charge transfer pathways |
10.1073/pnas.1808829115 | 41,736,636 | We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal-organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the death of strictly ana... | 10.1038/s41929-020-0428-y | A two-dimensional zirconium-based MOF nanosheet can be used to protect bacteria from oxygen and ROS |
10.1038/s41467-020-20470-z | 39,259,062 | Abstract Net primary production (NPP) is the foundation of the oceans’ ecosystems and the fisheries they support. In the Arctic Ocean, NPP is controlled by a complex interplay of light and nutrients supplied by upwelling as well as lateral inflows from adjacent oceans and land. But so far, the role of the input from la... | 10.1038/s43017-021-00232-1 | Highlights the importance of coastal erosion on ocean ecosystems and fisheries |
10.5194/tc-8-1777-2014 | 80,623,266 | Abstract. Sea ice limits the interaction of the land and ocean water in the Arctic winter and influences this interaction in the summer by governing the fetch. In many parts of the Arctic, the open-water season is increasing in duration and summertime sea-ice extents are decreasing. Sea ice provides a first-order contr... | 10.1038/s43017-021-00232-1 | Discusses the effect of sea ice on waves and water levels, and how changes in sea ice affect coastal erosion |
10.1029/jc090ic06p11983 | 20,830,499 | An analysis is made of the formation of a thermoerosional niche into a frozen bluff due to a storm surge on the Beaufort Sea coast. As a first attempt, the problem is treated as a one‐dimensional unsteady problem in which the vertical melting front of the thermoerosional niche migrates into the frozen bluff under the t... | 10.1038/s43017-021-00232-1 | One of the first, or perhaps the first, studies that presents a model of permafrost bluff niching, erosion and recession. |
10.1029/2019jc015745 | 121,411,291 | Abstract The Arctic Ocean wave climate is undergoing a dramatic change due to the sea ice retreat. This study presents simulations of the Arctic regional wave climate corresponding to the surface winds and sea ice concentrations as simulated by five CMIP5 (Coupled Model Intercomparison Project Phase 5) climate models f... | 10.1038/s43017-021-00232-1 | Presents the first end-of-twenty-first century, multimodel ensemble of projected extreme waves along the circum-Arctic coast |
10.1111/j.1365-2141.2008.07091.x | 125,092,476 | Summary Studies during the last three decades have enabled the development of detailed molecular insights into the structural basis of altered function in various inherited red cell membrane disorders. This review highlights our current understanding of molecular and mechanistic insights into various inherited red cell... | 10.1038/nrmicro2110 | Recent review of membrane protein organization in normal and abnormal RBCs. |
10.1126/science.8009226 | 20,658,159 | A 175-kilodalton erythrocyte binding protein, EBA-175, of the parasite Plasmodium falciparum mediates the invasion of erythrocytes. The erythrocyte receptor for EBA-175 is dependent on sialic acid. The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of EBA-175 ex... | 10.1038/nrmicro2110 | First identification of a ligand used by P. falciparum for invasion of RBCs |
10.1126/science.1102737 | 83,513,915 | Malaria parasites secrete proteins across the vacuolar membrane into the erythrocyte, inducing modifications linked to disease and parasite survival. We identified an 11–amino acid signal required for the secretion of proteins from the Plasmodium falciparum vacuole to the human erythrocyte. Bioinformatics predicted a s... | 10.1038/nrmicro2110 | References 78 and 79 define the motif that is involved in export of proteins across the PV membrane. |
10.1111/j.1365-2958.2008.06235.x | 26,839,821 | Summary During the intra‐erythrocytic development of Plasmodium falciparum , the parasite modifies the host cell surface by exporting proteins that interact with or insert into the erythrocyte membrane. These proteins include the principal mediator of cytoadherence, P. falciparum erythrocyte membrane protein 1 (PfEMP1)... | 10.1038/nrmicro2110 | Deletion of MAHRP1 alters Maurer's cleft morphology and interferes with PfEMP1 trafficking to the RBC surface. |
10.1083/jcb.200509122 | 18,744,866 | The high mortality of Plasmodium falciparum malaria is the result of a parasite ligand, PfEMP1 (P. falciparum) erythrocyte membrane protein 1), on the surface of infected red blood cells (IRBCs), which adheres to the vascular endothelium and causes the sequestration of IRBCs in the microvasculature. PfEMP1 transport to... | 10.1038/nrmicro2110 | First genetic knockdown of PfEMP1 in malaria parasites and first successful complementation of an asexual blood stage gene in P. falciparum |
10.1182/blood-2006-08-043364 | 18,607,314 | Abstract A key feature of Plasmodium falciparum, the parasite causing the most severe form of malaria in humans, is its ability to export parasite molecules onto the surface of the erythrocyte. The major virulence factor and variant surface protein PfEMP1 (P falciparum erythrocyte membrane protein 1) acts as a ligand t... | 10.1038/nrmicro2110 | References 152 and 153 show that deletion of PfSBP1 interferes with the trafficking of PfEMP1 to the RBC surface. |
10.1073/pnas.022018399 | 101,153,729 | Immunity to Plasmodium falciparum in African children has been correlated with antibodies to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant gene family expressed on the surface of infected red cells. We immunized Aotus monkeys with a subregion of the Malayan Camp variant antigen (MCvar1) that mediate... | 10.1038/nrmicro2110 | Demonstration of the importance of PfEMP1 in P. falciparum virulence. |
10.1146/annurev-biophys-070816-033654 | 103,704,632 | Binding free energy calculations based on molecular simulations provide predicted affinities for biomolecular complexes. These calculations begin with a detailed description of a system, including its chemical composition and the interactions among its components. Simulations of the system are then used to compute ther... | 10.1038/s43588-023-00396-4 | A review article that presents different binding free energy estimation methods. |
10.1073/pnas.0409005102 | 125,093,169 | A general methodology for calculating the equilibrium binding constant of a flexible ligand to a protein receptor is formulated on the basis of potentials of mean force. The overall process is decomposed into several stages that can be computed separately: the free ligand in the bulk is first restrained into the confor... | 10.1038/s43588-023-00396-4 | A research article that pioneers the stratification strategy for binding affinity estimation. |
10.1126/science.aat8126 | 101,062,357 | Although flakes of two-dimensional (2D) heterostructures at the micrometer scale can be formed with adhesive-tape exfoliation methods, isolation of 2D flakes into monolayers is extremely time consuming because it is a trial-and-error process. Controlling the number of 2D layers through direct growth also presents diffi... | 10.1038/s43586-022-00122-w | This paper demonstrates the principles of 2DLT and the role of stressor layers, which are theoretically investigated and experimentally shown |
10.1126/sciadv.aaz5180 | 61,035,332 | There have been rapidly increasing demands for flexible lighting apparatus, and micrometer-scale light-emitting diodes (LEDs) are regarded as one of the promising lighting sources for deformable device applications. Herein, we demonstrate a method of creating a deformable LED, based on remote heteroepitaxy of GaN micro... | 10.1038/s43586-022-00122-w | This paper reports flexible blue LEDs realized by remote epitaxy of GaN micro-rods |
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