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10.1038/s41467-021-21708-0 | 29,130,890 | Abstract Wildfires are becoming more frequent and destructive in a changing climate. Fine particulate matter, PM 2.5 , in wildfire smoke adversely impacts human health. Recent toxicological studies suggest that wildfire particulate matter may be more toxic than equal doses of ambient PM 2.5 . Air quality regulations ho... | 10.1038/s41893-022-00958-w | This paper reports that wildfire smoke affects respiratory health more than ambient air pollution. |
10.1002/adsc.200600389 | 101,752,628 | Abstract Palladium( II ) acetate‐catalyzed Heck‐type reactions have been performed from the arene 1 and alkenes ( n ‐butyl acrylate, styrene) in acetic acid at room temperature, in the presence of a catalytic amount of benzoquinone or hydroquinone. The reactions have been made catalytic in benzoquinone [which is used t... | 10.1038/s44160-022-00199-x | This paper reports a Pd-catalysed electrochemical oxidative Heck-type reaction using the divided cell. |
10.1038/ncomms6788 | 62,391,685 | Abstract Decay of surface plasmons to hot carriers finds a wide variety of applications in energy conversion, photocatalysis and photodetection. However, a detailed theoretical description of plasmonic hot-carrier generation in real materials has remained incomplete. Here we report predictions for the prompt distributi... | 10.1038/s43586-023-00195-1 | This work provides a theoretical description of plasmonic hot carrier generation in different plasmonic materials |
10.1126/science.aao0872 | 19,844,902 | Direct plasmon chemistry Light can excite plasmons at a metal surface, which can then decay and create hot electrons that induce chemical reactions of adsorbed molecules. Kazuma et al. used a scanning tunneling microscope (STM) to induce and map out the surface dissociation of a dimethyl disulfide molecule on silver an... | 10.1038/s43586-023-00195-1 | This work discusses real-time and real-space mapping of a PMCR |
10.1126/science.aac5443 | 62,433,960 | Improving electron harvesting Small metal nanostructures generate electrons from light by creating surface plasmons, which can transfer “hot electrons” to a semiconductor. The efficiency of this process, however, is often low because of electron-electron scattering. Wu et al. demonstrate a pathway that allows the plasm... | 10.1038/s43586-023-00195-1 | This work shows that plasmon-induced interfacial charge transfer transition is demonstrated by transient spectroscopy |
10.1038/s41467-019-10771-3 | 62,519,764 | Abstract Plasmon-mediated chemical reactions (PMCRs) constitute a vibrant research field, advancing such goals as using sunlight to convert abundant precursors such as CO 2 and water to useful fuels and chemicals. A key question in this burgeoning field which has not, as yet, been fully resolved, relates to the precise... | 10.1038/s43586-023-00195-1 | This work presents the unique photoelectrochemical feature of plasmonic electrodes |
10.1126/science.aat6967 | 62,624,356 | Photocatalysis based on optically active, “plasmonic” metal nanoparticles has emerged as a promising approach to facilitate light-driven chemical conversions under far milder conditions than thermal catalysis. However, an understanding of the relation between thermal and electronic excitations has been lacking. We repo... | 10.1038/s43586-023-00195-1 | This article uses light-dependent activation barriers to distinguish the hot carrier and thermal contributions in PMCRs, and has sparked a lot of discussion about temperature measurement in PMCR systems |
10.1073/pnas.1609769113 | 60,894,943 | Metallic nanoparticles with strong optically resonant properties behave as nanoscale optical antennas, and have recently shown extraordinary promise as light-driven catalysts. Traditionally, however, heterogeneous catalysis has relied upon weakly light-absorbing metals such as Pd, Pt, Ru, or Rh to lower the activation ... | 10.1038/s43586-023-00195-1 | This work presents heterometallic antenna−reactor complexes with a plasmonic nanostructure and catalytic mediator for PMCRs |
10.1126/science.285.5430.1042 | 125,070,774 | Heating of a ruthenium surface on which carbon monoxide and atomic oxygen are coadsorbed leads exclusively to desorption of carbon monoxide. In contrast, excitation with femtosecond infrared laser pulses enables also the formation of carbon dioxide. The desorption is caused by coupling of the adsorbate to the phonon ba... | 10.1038/s43586-023-00195-1 | This article presents a comparison of phonon-mediated and electron-mediated chemical reaction |
10.1038/s41467-020-18016-4 | 101,374,849 | Abstract Surface plasmons (SPs) of metals enable the tight focusing and strong absorption of light to realize an efficient utilization of photons at nanoscale. In particular, the SP-generated hot carriers have emerged as a promising way to efficiently drive photochemical and photoelectric processes under moderate condi... | 10.1038/s43586-023-00195-1 | This article uses TERS to probe the nanoscale spatial distribution of plasmonically excited hot carriers |
10.1007/s12551-018-0419-2 | 20,773,013 | Abstract There is no doubt that ionic liquids have become a major subject of study for modern chemistry. We have become used to ever more publications in the field each year, although there is some evidence that this is beginning to plateau at approximately 3500 papers each year. They have been the subject of several m... | 10.1038/s43586-022-00129-3 | This introductory review discusses the evolution of the field of ILs, in terms of both fundamental understanding and practical applications |
10.1071/ch08558 | 38,257,718 | Phosphonium cation-based ionic liquids (ILs) are a readily available family of ILs that in some applications offer superior properties as compared to nitrogen cation-based ILs. Applications recently investigated include their use as extraction solvents, chemical synthesis solvents, electrolytes in batteries and super-c... | 10.1038/s43586-022-00129-3 | This thorough review introduces phosphonium cations for ILs, from their synthesis to their potential applications |
10.1351/pac200072122275 | 83,175,039 | We report here the first systematic study of the effect of impurities and additives (e.g., water, chloride, and cosolvents) on the physical properties of room-temperature ionic liquids. Remarkably, it was discovered that the viscosity of mixtures was dependent mainly on the mole fraction of added molecular solvents and... | 10.1038/s43586-022-00129-3 | This work discusses the effect of common contaminants on the physical properties of ILs |
10.1111/jhn.12904 | 41,076,330 | Abstract Background Dietary risks have raised attention worldwide during recent decades. The present burden‐of‐disease study aimed to evaluate the global dietary risks for non‐communicable diseases (NCDs) from 1990 to 2019 and quantify their impact on mortality and disability‐adjusted life‐years (DALYs). Data from the ... | 10.1038/s43016-022-00554-3 | A burden-of-disease study that presents the effects of dietary risks for NCDs on mortality and disability-adjusted life-years worldwide. |
10.1258/1355819054308530 | 20,700,512 | Evidence-based policy is a dominant theme in contemporary public services but the practical realities and challenges involved in using evidence in policy-making are formidable. Part of the problem is one of complexity. In health services and other public services, we are dealing with complex social interventions which ... | 10.1038/s43016-022-00554-3 | This article describes the realist review methodology used in our research. |
10.1038/s41467-020-17473-1 | 103,587,984 | Abstract Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused discovery strategy to provide an extensive map of O-glycans on peptide hormones. We find that... | 10.1038/s43586-022-00128-4 | Seminal work that describes the discovery of widespread O -glycosylation of endogenous peptide hormones with diverse biological functions |
10.1073/pnas.1813020116 | 102,910,767 | Mucin domains are densely O -glycosylated modular protein domains that are found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are known to be key players in a host of human diseases, especially cancer, wherein mucin expression and glycosylation patterns are altered. Mucin biology ... | 10.1038/s43586-022-00128-4 | Seminal paper that introduces the concept of using mucin-selective proteases to access previously inaccessible regions of the glycoproteome |
10.1002/jms.3210 | 40,117,707 | Mass spectrometry (MS) is used to quantify the relative distribution of glycans attached to particular protein glycosylation sites (micro‐heterogeneity) and evaluate the molar site occupancy (macro‐heterogeneity) in glycoproteomics. However, the accuracy of MS for such quantitative measurements remains to be clarified.... | 10.1038/s43586-022-00128-4 | A critical study providing some of the only experimental evidence on the impact of glycosylation events on the observed MS signal of glycopeptides compared with matching unglycosylated peptides at equal concentrations |
10.1155/2012/560391 | 17,441,654 | Currently, glycans are attracting attention from the scientific community as potential biomarkers or as posttranslational modifications (PTMs) of therapeutic proteins. However, structural characterization of glycoproteins and glycopeptides remains analytically challenging. Here, we report on the implementation of a nov... | 10.1038/s43586-022-00128-4 | Critical work that outlines the first example of using oxonium fragment ions to trigger the collection of electron transfer dissociation data |
10.1002/adma.201902254 | 20,704,093 | Abstract Over the past decade, the area of stretchable inorganic electronics has evolved very rapidly, in part because the results have opened up a series of unprecedented applications with broad interest and potential for impact, especially in bio‐integrated systems. Low modulus mechanics and the ability to accommodat... | 10.1038/s41928-023-00919-x | A review article that presents the strategies for developing stretchable electronic devices. |
10.1126/science.1127899 | 38,375,876 | Although enzymes often incorporate molecular recognition elements to orient substrates selectively, such strategies are rarely achieved by synthetic catalysts. We combined molecular recognition through hydrogen bonding with C-H activation to obtain high-turnover catalytic regioselective functionalization of sp 3 C-H bo... | 10.1038/s43586-021-00041-2 | This publication constitutes a milestone in C–H activation chemistry, owing to the elegant design of a hydrogen-bonding linker, which non-covalently binds to the substrates and enables remote C–H activation |
10.1002/anie.201812215 | 62,030,150 | Abstract Recent advances in Cp x M III catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp 2 )−H functionalization reactions, but enantioselective C(sp 3 )−H functionalization is still largely unexplored. We describe an asymmetric C(sp 3 )−H amidation of thioamides using an achiral Co III /chiral c... | 10.1038/s43586-021-00041-2 | This study accomplishes challenging asymmetric amidations of C( sp 3 )–H bonds via Earth-abundant cobalt/chiral carboxylic acid catalysis |
10.1039/c9cc06971b | 103,362,570 | PdNP bionanohybrid catalyzed selective C–H bond arylation of tryptophan residues in proteins in aqueous media at room temperature. | 10.1038/s43586-021-00041-2 | This publication represents the forefront of the application of C–H activation to peptide modification, detailing the site-selective C–H activation of one or two Trp residues in the protein Cal-B in aqueous media at room temperature using a palladium nanoparticle biohybrid catalyst |
10.1002/anie.201904214 | 125,315,691 | Abstract Molecular syntheses largely rely on time‐ and labour‐intensive prefunctionalization strategies. In contrast, C−H activation represents an increasingly powerful approach that avoids lengthy syntheses of prefunctionalized substrates, with great potential for drug discovery, the pharmaceutical industry, material ... | 10.1038/s43586-021-00041-2 | This review summarizes recent developments in the challenging area of asymmetric C–H activation under environmentally benign 3 d transition metal catalysis |
10.1002/anie.201915624 | 123,813,892 | Abstract A simple and efficient nitrile‐directed meta ‐C−H olefination, acetoxylation, and iodination of biaryl compounds is reported. Compared to the previous approach of installing a complex U‐shaped template to achieve a molecular U‐turn and assemble the large‐sized cyclophane transition state for the remote C−H act... | 10.1038/s43586-021-00041-2 | This combined experimental and computational study discloses efficient and selective nitrile-directed meta -C–H activations, proceeding through a hetero-bimetallic silver–palladium intermediate |
10.1038/ncomms10783 | 102,571,535 | Abstract Optoelectronic devices utilizing graphene have demonstrated unique capabilities and performances beyond state-of-the-art technologies. However, requirements in terms of device quality and uniformity are demanding. A major roadblock towards high-performance devices are nanoscale variations of the graphene devic... | 10.1038/s42254-022-00551-2 | This experiment demonstrated photocurrent mapping with 20 nm spatial resolution by combining a near-field microscope with photocurrent detection |
10.1126/sciadv.1501524 | 62,282,411 | There are a variety of nonlinear optical effects including higher harmonic generations, photovoltaic effects, and nonlinear Kerr rotations. They are realized by strong light irradiation to materials that results in nonlinear polarizations in the electric field. These are of great importance in studying the physics of e... | 10.1038/s42254-022-00551-2 | This paper unveiled the intimate connection between nonlinear optical responses and quantum geometry |
10.1126/science.aaz9146 | 35,655,271 | Van der Waals interfaces can be formed by layer stacking without regard to lattice constants or symmetries of individual building blocks. We engineered the symmetry of a van der Waals interface of tungsten selenide and black phosphorus and realized in-plane electronic polarization that led to the emergence of a spontan... | 10.1038/s42254-022-00551-2 | This experiment realized bulk quantum geometric photocurrents in a two-dimensional heterostructure using van der Waals interface engineering |
10.1126/science.1211384 | 83,451,413 | Photoexcited electrons in graphene remain thermally excited because they cannot transfer this energy to lattice vibrations. | 10.1038/s42254-022-00551-2 | This experiment demonstrated how the photothermoelectric effect dominates the photocurrent response of graphene and bilayer graphene |
10.1542/peds.2006-1801 | 21,790,449 | OBJECTIVE. This was a systematic evidence review for the US Preventive Services Task Force, intended to synthesize the published evidence regarding the effectiveness of selecting, testing, and managing children and adolescents with dyslipidemia in the course of routine primary care. METHODS. Literature searches were pe... | 10.1038/s41598-022-21262-9 | Evidence Syntheses, No. 47. Appendix 2. Units of measure conversion formulas |
10.1073/pnas.1312752110 | 20,155,578 | It is indisputable that modern life is enabled by the use of materials in its technologies. Those technologies do many things very well, largely because each material is used for purposes to which it is exquisitely fitted. The result over time has been a steady increase in product performance. We show that this materia... | 10.1038/s43017-021-00211-6 | Identified the growing trend for complexity of materials in modern society |
10.3390/min8120560 | 18,636,858 | Geometallurgy is an important addition to any evaluation project or mining operation. As an integrated approach, it establishes 3D models which enable the optimisation of net present value and effective orebody management, while minimising technical and operational risk to ultimately provide more resilient operations. ... | 10.1038/s43017-021-00211-6 | Providing a guideline and an overview on how to approach geometallurgy to understand mine operations and increase resilience of the operation |
10.1111/j.1532-5415.1972.tb00787.x | 103,818,707 | ABSTRACT: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen co... | 10.1038/s43587-023-00364-7 | An early article proposing mitochondria as central in controlling the rate of aging. |
10.1038/s41598-020-71269-3 | 123,574,431 | Abstract We study biological aging of elderly U.S. Americans born 1904–1966. We use thirteen waves of the Health and Retirement Study and construct a frailty index as the number of health deficits present in a person measured relative to the number of potential deficits. We find that, on average, Americans develop 5% m... | 10.1038/s43587-021-00099-3 | This paper demonstrates the use of the frailty index as a biological foundation of health economic theory |
10.2307/2061224 | 62,330,777 | Abstract Life table methods are developed for populations whose members differ in their endowment for longevity. Unlike standard methods, which ignore such heterogeneity, these methods use different calculations to construct cohort, period, and individual life tables. The results imply that standard methods overestimat... | 10.1038/s43587-021-00099-3 | This paper introduced the notion of variability in the rates of aging as defining frailty |
10.1100/tsw.2001.58 | 83,292,358 | This paper develops a method for appraising health status in elderly people. A frailty index was defined as the proportion of accumulated deficits (symptoms, signs, functional impairments, and laboratory abnormalities). It serves as an individual state variable, reflecting severity of illness and proximity to death. In... | 10.1038/s43587-021-00099-3 | This paper introduced the concept of frailty as a state defined by the accumulation of deficits |
10.1093/ageing/afz088 | 41,316,323 | Abstract Background routine frailty identification and management is national policy in England, but there remains a lack of evidence on the impact of frailty on healthcare resource use. We evaluated the impact of frailty on the use and costs of general practice and hospital care. Methods retrospective longitudinal ana... | 10.1038/s43587-021-00099-3 | This representative study suggests that per person cost to the health care system increases with the degree of frailty |
10.1017/thg.2016.72 | 20,380,550 | Our study examines the contribution of genetic and environmental factors (both shared and unique) to frailty, measured using the Rockwood Frailty Index (FI) in a sample of twins from the St Thomas’ UK Adult Twin Registry. The FI was based on 39 items of potential health deficit. Study participants were 3,375 volunteer ... | 10.1038/s43587-021-00099-3 | This twin study suggests that about half of the interindividual variation in frailty is heritable |
10.1007/s00439-020-02249-w | 58,849,801 | Abstract Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most aging-related diseases as well as immunological processes. However, little is known about aging, lifestyle and genetic factors influencing mitochondrial DNA (mtDNA) abundance. In this study, mtDNA abundance was estimated fr... | 10.1038/s43587-021-00099-3 | This paper demonstrates that mitochondrial dysfunction is related to the degree of frailty in a sex-specific fashion |
10.1038/srep43068 | 104,269,813 | Abstract Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measuring variability in health in animals of the same age. In humans, this variability has been quantified by... | 10.1038/s43587-021-00099-3 | This paper demonstrates that deficits accumulate in similar patterns across the life course in humans and in mice |
10.1093/gerona/gly219 | 123,598,460 | Abstract Studies on interventions that can delay or treat frailty in humans are limited. There is evidence of beneficial effects of angiotensin converting enzyme (ACE) inhibitors on aspects related to frailty, such as physical function, even in those without cardiovascular disease. This study aimed to longitudinally in... | 10.1038/s43587-021-00099-3 | This paper shows that long-term treatment of older mice with a drug that reduces inflammation improves health span |
10.1038/s41467-020-17910-1 | 79,693,661 | Abstract Through advanced mechanistic modeling and the generation of large high-quality datasets, machine learning is becoming an integral part of understanding and engineering living systems. Here we show that mechanistic and machine learning models can be combined to enable accurate genotype-to-phenotype predictions.... | 10.1038/s41929-022-00836-w | Good illustration of integrated system metabolic engineering approaches in yeast, based on modeling to identify five gene targets, Cas9-based editing of promoters variants for these genes, recording data with a tryptophan biosensor and using generated data for machine learning for further improve tryptophan production |
10.1073/pnas.2001588117 | 100,351,763 | Exploiting bacteriophage-derived homologous recombination processes has enabled precise, multiplex editing of microbial genomes and the construction of billions of customized genetic variants in a single day. The techniques that enable this, multiplex automated genome engineering (MAGE) and directed evolution with rand... | 10.1038/s41929-022-00836-w | This study provides a platform for identifying efficient single-stranded annealing proteins and allowed for more efficient recombineering in E. coli and several other bacteria |
10.1093/femsle/fnz086 | 45,477,422 | ABSTRACT Microbial production of chemical compounds often requires highly engineered microbial cell factories. During the last years, CRISPR-Cas nucleases have been repurposed as powerful tools for genome editing. Here, we briefly review the most frequently used CRISPR-Cas tools and describe some of their applications.... | 10.1038/s41929-022-00836-w | This review provides a comprehensive overview of CRISPR-Cas techniques and their performance for multiplexing in prokaryotic and eukaryotic microorganisms |
10.1038/s41467-022-30780-z | 128,017,003 | Abstract CRISPR/Cas technologies constitute a powerful tool for genome engineering, yet their use in non-traditional bacteria depends on host factors or exogenous recombinases, which limits both efficiency and throughput. Here we mitigate these practical constraints by developing a widely-applicable genome engineering ... | 10.1038/s41929-022-00836-w | This work established and demonstated an efficient base-editing tool for multiplex editing in the emerging model organism P. putida |
10.1073/pnas.1409523111 | 42,627,946 | Significance Microbes can be made to produce industrially valuable chemicals in high quantities by engineering their central metabolic pathways. This process may require evaluating billions of cells, each containing a unique pathway design, to identify the rare cells with high production phenotypes. We mutated targeted... | 10.1038/s41929-022-00836-w | This study demontrates the strenght of combining rational genome-wide targetting (MAGE) with product biosensors controlling selectable markers, leading to many-fold improved naringenin and glucaric acid production in E. coli |
10.7551/mitpress/1120.001.0001 | 74,943,792 | The proceedings of the 2001 Neural Information Processing Systems (NIPS) Conference. The annual conference on Neural Information Processing Systems (NIPS) is the flagship conference on neural computation. The conference is interdisciplinary, with contributions in algorithms, learning theory, cognitive science, neurosci... | 10.1038/s43588-022-00300-6 | An article that presents an early version of a mixture of Gaussian processes model. |
10.5194/wes-7-2491-2022 | 139,509,031 | Abstract. Wind energy is anticipated to play a central role in enabling a rapid transition from fossil fuels to a system based largely on renewable power. For wind power to fulfill its expected role as the backbone – providing nearly half of the electrical energy – of a renewable-based, carbon-neutral energy system, cr... | 10.1038/s43017-020-0101-7 | Emphasizes important trends within the wind energy industry and highlights resulting key research avenues |
10.1029/2018jd030094 | 82,454,191 | Abstract The year 2019 marks the thirtieth anniversary of the development of the first regional climate model (RCM), and here an overview is provided of the progress in regional modeling research and of the main challenges lying ahead. RCMs were primarily developed to provide fine‐scale climate information for impact s... | 10.1038/s43017-020-0101-7 | Summarizes the history of, challenges to and new prospects for regional climate modelling |
10.1038/s41467-020-16782-9 | 28,210,551 | Abstract Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label, non-randomized phase II study comparing NIHP to static cold preservation (SCS), the current standard for adult heart transplantation.... | 10.1038/s44161-022-00112-x | This is the clinical trial for non-ischemic cardiac preservation that is currently used to overcome primary graft dysfunction in allotransplantation and that seems to uniquely suite cardiac xenotransplantation as well. |
10.1111/xen.12161 | 103,623,834 | Abstract Background Simultaneous inactivation of pig GGTA 1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4Gal NT 2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan‐based species incompatibilities, we examined human and non‐human primate ant... | 10.1038/s44161-022-00112-x | This paper first demonstrated a potential paradoxical effect of carbohydrate knockouts in preclinical models in Old World monkey recipients of porcine-derived xenografts that is distinct from human recipients |
10.4049/jimmunol.155.11.5249 | 139,052,991 | Abstract Partially inbred, MHC homozygous miniature swine have been used to study the nature of the human xenogeneic cellular immune response to swine Ags in vitro. Human T cells responded to xeno-MHC Ags in MLR at least as well as they did to allo-MHC Ags and appeared to share similar requirements for APC of either st... | 10.1038/s44161-022-00112-x | This paper demonstrates the ability for human T cells to recognize porcine antigens via both direct and indirect means, laying to rest a previously controversial topic |
10.1038/ncomms11138 | 103,924,399 | Abstract Preventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and human thrombomodulin ( GTK... | 10.1038/s44161-022-00112-x | This study demonstrated proof-of-principle rejection-free survival in cardiac xenotransplantation using genetically modified pig donors with co-stimulation blockade, measured in years |
10.1111/xen.12744 | 135,717,341 | Abstract We report orthotopic (life‐supporting) survival of genetically engineered porcine cardiac xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work builds on our previously reported heterotopic cardiac xenograft (three gene modifications) survival up to 945 days with an anti‐... | 10.1038/s44161-022-00112-x | This paper demonstrated the longest survival to date in preclinical models of life-supporting cardiac xenotransplantation. |
10.1084/jem.171.4.1363 | 16,689,717 | Heparan sulfate proteoglycan associated with endothelial cells in normal blood vessels inhibits intravascular coagulation and egress of blood cells and plasma proteins, key features of hyperacute rejection. It was shown herein that exposure of cultured porcine endothelium to human serum as a source of natural antibodie... | 10.1038/s44161-022-00112-x | One of the sentinel papers describing incompatibilities between porcine and human-derived coagulation factors |
10.1111/xen.12576 | 34,380,315 | Abstract Background Transpulmonary thermodilution is well established as a tool for in‐depth hemodynamic monitoring of critically ill patients during surgical procedures and intensive care. It permits easy assessment of graft function following cardiac transplantation and guides post‐operative volume and catecholamine ... | 10.1038/s44161-022-00112-x | A paper that describes the physiological mismatch between pigs and non-human primates |
10.1111/j.1399-3089.2012.00693.x | 60,918,263 | Fishman JA, Scobie L, Takeuchi Y. Xenotransplantation‐associated infectious risk: a WHO consultation. Xenotransplantation 2012; 19: 72–81. © 2012 John Wiley & Sons A/S. Abstract: Xenotransplantation carries the potential risk of the transmission of infection with the cells or tissues of the graft. The degree of ris... | 10.1038/s44161-022-00112-x | An authoritative publication on the zoonotic risks of cross-species transplantation from swine |
10.1111/xen.12595 | 101,319,111 | Abstract Post‐transplantation infections are common. In immunosuppressed human xenograft recipients, infection is most likely to be due to the same pathogens seen in human allotransplantation. However, organisms derived from swine and transmitted with xenografts have the potential to cause novel infections in xenograft... | 10.1038/s44161-022-00112-x | The use of pathogen-free facility herds for source animals in solid-organ xenotransplantation to reduce the risk of xenozoonosis |
10.1101/gad.176826.111 | 62,622,635 | Transcription factors are adaptor molecules that detect regulatory sequences in the DNA and target the assembly of protein complexes that control gene expression. Yet much of the DNA in the eukaryotic cell is in nucleosomes and thereby occluded by histones, and can be further occluded by higher-order chromatin structur... | 10.1038/s43586-020-00008-9 | This review article describes the main properties of pioneer factors and their important role in establishing the chromatin landscape and in enabling cellular reprogramming |
10.1101/gr.143008.112 | 62,297,409 | DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using nuclease digestion requiring significant amounts of material and varying enzyme concentrations. We have developed a method (NOMe-seq) that uses a GpC methyltran... | 10.1038/s43586-020-00008-9 | This study develops the first genome-wide assay for single-molecule chromatin accessibility profiling, relying on methyltransferase enzymes that preferentially modify accessible DNA |
10.1126/science.948749 | 122,496,939 | Ten percent digestion of isolated nuclei by pancreatic deoxyribonuclease I preferentially removes globin DNA sequences from nuclei obtained from chick red blood cells but not from nuclei obtained from fibroblasts, from brain, or from a population of red blood cell precursors. Moreover, the nontranscribed ovalbumin sequ... | 10.1038/s43586-020-00008-9 | This pioneering work in the field of regulatory genomics shows that genomic regions of active transcription are particularly sensitive to digestion by DNase I, indicating a more permissive form of the chromatin |
10.1126/science.aab1601 | 41,705,559 | Chromatin state and the single cell Identifying the chromatin state of any single cell, which may or may not have a different function or represent different stages relative to others collected within any single culture, experiment, or tissue, has been challenging. Cusanovitch et al. skirted previously identified techn... | 10.1038/s43586-020-00008-9 | This study is one of the first to perform genome-wide chromatin accessibility profiling at a single-cell level, thus spearheading the now rising use of scATAC-seq |
10.1126/science.aau0730 | 62,310,361 | Although we can increasingly measure transcription, chromatin, methylation, and other aspects of molecular biology at single-cell resolution, most assays survey only one aspect of cellular biology. Here we describe sci-CAR, a combinatorial indexing–based coassay that jointly profiles chromatin accessibility and mRNA (C... | 10.1038/s43586-020-00008-9 | This work establishes the first scalable genome-wide technique that allows simulations profiling transcription and chromatin accessibility on a single-cell level, illustrating the advantage of a multi-omics single-cell assay to link regulatory elements to regulated genes |
10.1177/0361684313480044 | 100,901,725 | The validity and internal reliability for scores on four popular measures of sexist beliefs (the Modern Sexism scale, the Attitudes Toward Women scale, and the Benevolent and Hostile Sexism subscales of the Ambivalent Sexism Inventory; collected from 1994 to 1999 with college students) were tested across four U.S. ethn... | 10.1038/s44159-022-00136-x | This article highlights measurement invariance across ethnic/racial groups, pointing to the need to consider the cultural context of ambivalent sexism |
10.1038/ncomms6305 | 20,670,491 | Abstract In the discipline of bottom-up synthetic biology, vesicles define the boundaries of artificial cells and are increasingly being used as biochemical microreactors operating in physiological environments. As the field matures, there is a need to compartmentalize processes in different spatial localities within v... | 10.1038/s41929-020-0433-1 | The study describes the preparation of inter-connected lipid-stabilized microdroplets loaded with three enzymes and the operation of a multi-enzyme cascade in the ensemble |
10.1002/chem.201404122 | 60,082,855 | Abstract Mimicking cellular transformations and signal transduction pathways by means of biocatalytic cascades proceeding in organized media is a scientific challenge. We describe two DNA machines that enable the “ON/OFF” switchable activation and deactivation of three‐component biocatalytic cascades. One system consis... | 10.1038/s41929-020-0433-1 | The study introduces the switchable operation of a three-biocatalyst cascade using a DNA tweezer scaffold as driving machinary |
10.1073/pnas.0903323106 | 18,288,645 | The ≈3,450-million-year-old Strelley Pool Formation in Western Australia contains a reef-like assembly of laminated sedimentary accretion structures (stromatolites) that have macroscale characteristics suggestive of biological influence. However, direct microscale evidence of biology—namely, organic microbial remains o... | 10.1038/s43017-021-00169-5 | Detailed characterization of the morphological variation within the oldest assemblage of biogenic stromatolites |
10.1146/annurev-earth-042711-105327 | 103,046,691 | Stromatolites document microbial interactions with sediments and flowing water throughout recorded Earth history and have the potential to illuminate the long-term history of life and environments. Modern stromatolites, however, provide analogs to only a small subset of the structures preserved in Archean and Proterozo... | 10.1038/s43017-021-00169-5 | Review of stromatolite morphogenesis that considers the potential of stromatolite growth models and analyses to address biogenicity and reconstruct processes |
10.1126/science.1242777 | 62,205,018 | The Curiosity rover discovered fine-grained sedimentary rocks, which are inferred to represent an ancient lake and preserve evidence of an environment that would have been suited to support a martian biosphere founded on chemolithoautotrophy. This aqueous environment was characterized by neutral pH, low salinity, and v... | 10.1038/s43017-021-00169-5 | Sedimentary and chemical context of the lacustrine palaeoenvironment in Gale crater |
10.1146/annurev-earth-092010-152509 | 103,793,489 | Near-surface reaction of CO 2 -bearing fluids with silicate minerals in peridotite and basalt forms solid carbonate minerals. Such processes form abundant veins and travertine deposits, particularly in association with tectonically exposed mantle peridotite. This is important in the global carbon cycle, in weathering, ... | 10.1038/s43017-021-00169-5 | Review of water–rock reactions, processes and mineral products in ultramafic environments |
10.1126/science.aas9185 | 83,101,703 | Establishing the presence and state of organic matter, including its possible biosignatures, in martian materials has been an elusive quest, despite limited reports of the existence of organic matter on Mars. We report the in situ detection of organic matter preserved in lacustrine mudstones at the base of the ~3.5-bil... | 10.1038/s43017-021-00169-5 | In situ detection of carbonaceous material in the mudstones of Gale crater, Mars, by the Curiosity rover team |
10.1126/science.1258122 | 123,918,601 | The valley pseudospin is a degree of freedom that emerges in atomically thin two-dimensional transition metal dichalcogenides (MX 2 ). The capability to manipulate it, in analogy to the control of spin in spintronics, can open up exciting opportunities. Here, we demonstrate that an ultrafast and ultrahigh valley pseudo... | 10.1038/s42254-020-00276-0 | This study represents one of the earliest reports to engineer time-reversal symmetry breaking through coherent light–matter interaction |
10.1063/5.0012249 | 62,494,937 | We investigate WSe2–MoSe2 heterobilayers with different twist angles θ±δ between the two layers by low-frequency Raman scattering. In sufficiently aligned samples with θ=0° or θ=60° and δ≲3°, we observe an interlayer shear mode (ISM), which is a clear sign of a commensurate bilayer structure, i.e., the layers must unde... | 10.1038/s42254-020-00259-1 | A study that shows evidence of atomic reconstruction and stacking order in heterobilayers by means of low-frequency Raman spectroscopy |
10.3847/1538-4357/ab042c | 62,601,613 | Abstract We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the solar system, exploring the transient optical sky, and mapping the Milk... | 10.1038/s42254-019-0067-x | Overview of the design specifications and the science requirements of LSST |
10.1146/annurev-astro-081817-051756 | 123,197,809 | In our modern understanding of galaxy formation, every galaxy forms within a dark matter halo. The formation and growth of galaxies over time is connected to the growth of the halos in which they form. The advent of large galaxy surveys as well as high-resolution cosmological simulations has provided a new window into ... | 10.1038/s42254-019-0067-x | Review of the physics driving the relationship between galaxies, their observable properties and their host dark matter halos |
10.1155/2015/272858 | 67,591,685 | Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues. The adherens junction, a major mechanism of intercellular adhesion, is comprised of transmembrane cadherins forming homotypic interactions betw... | 10.1038/s44161-022-00195-6 | A review article that presents studies on the regulation of the vascular barrier through tyrosine phosphorylation. |
10.1038/s41467-020-16640-8 | 83,186,289 | Abstract Nanoelectronic devices based on 2D materials are far from delivering their full theoretical performance potential due to the lack of scalable insulators. Amorphous oxides that work well in silicon technology have ill-defined interfaces with 2D materials and numerous defects, while 2D hexagonal boron nitride do... | 10.1038/s41928-022-00835-6 | A review article that presents the insulators used in 2D semiconductors and the methods of quality evaluation. |
10.1155/2018/9593267 | 28,262,217 | Slow-moving clayey earthslides frequently exhibit seasonal activity suggesting that deformation processes do not only depend on slope and intrinsic geomechanical parameters. On the contrary, seasonal motion patterns are frequently observed with acceleration during the wet season and deceleration during the dry season. ... | 10.1038/s43017-020-0072-8 | Special issue “The Role and Impact of Geofluids in Geohazards” |
10.1126/science.1250366 | 41,750,535 | In the Kondo insulator samarium hexaboride (SmB 6 ), strong correlation and band hybridization lead to an insulating gap and a diverging resistance at low temperature. The resistance divergence ends at about 3 kelvin, a behavior that may arise from surface conductance. We used torque magnetometry to resolve the Fermi s... | 10.1038/s42254-020-0210-8 | This study is the first report of the quantum oscillations in magnetization in Kondo insulators |
10.1073/pnas.1901245116 | 102,939,372 | The inverted resistance method was used in this study to extend the bulk resistivity of S m B 6 to a regime where the surface conduction overwhelms the bulk. Remarkably, regardless of the large off-stoichiometric growth conditions (inducing disorder by samarium vacancies, boron interstitials, etc.), the bulk resistivit... | 10.1038/s42254-020-0210-8 | This study reveals the robust bulk insulating gap in SmB 6 |
10.1038/s41467-019-10353-3 | 52,737,607 | Abstract The peculiar metallic electronic states observed in the Kondo insulator, samarium hexaboride (SmB 6 ), has stimulated considerable attention among those studying non-trivial electronic phenomena. However, experimental studies of these states have led to controversial conclusions mainly due to the difficulty an... | 10.1038/s42254-020-0210-8 | The first direct observation of spin-textured surface states for a SmB 6 surface other than the natural (100) cleavage plane |
10.1038/s41467-018-05258-6 | 125,186,972 | Abstract Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. Here we show, through direct live-cell imaging of young, middle-aged, and old-aged primary human dermal fibroblasts, that aneuploidy increases with aging due ... | 10.1038/s43587-022-00211-1 | This paper reports that FOXM1 induction in mouse fibroblasts from naturally aged mice and those with Hutchison–Gilford progeria syndrome ameliorates cellular aging phenotypes |
10.1242/jcs.183954 | 62,509,787 | ABSTRACT Ubiquitin plays an essential role in modulating protein functions, and deregulation of the ubiquitin system leads to the development of multiple human diseases. Owing to its molecular features, ubiquitin can form various homo- and heterotypic polymers on substrate proteins, thereby provoking distinct cellular ... | 10.1038/s43586-021-00048-9 | This paper presents a method to unravel the complex architecture of ubiquitin chains to understand polyubiquitin signals |
10.1038/ncomms14109 | 20,080,994 | Abstract Crosstalk between the SUMO and ubiquitin pathways has recently been reported. However, no approach currently exists to determine the interrelationship between these modifications. Here, we report an optimized immunoaffinity method that permits the study of both protein ubiquitylation and SUMOylation from a sin... | 10.1038/s43586-021-00048-9 | This paper uses a dual-remnant immunoaffinity enrichment to identify protein SUMOylation and ubiquitylation in a site-specific manner |
10.1038/s41467-017-01271-3 | 83,116,337 | Abstract Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins. Proteome-wide detection of SUMOylation sites on target pro... | 10.1038/s43586-021-00048-9 | This paper features a method to enrich endogenous SUMOylated proteins and their identification by mass spectrometry, revealing more than 1,200 SUMO sites |
10.1126/science.1125907 | 62,547,989 | Using the freedom of design that metamaterials provide, we show how electromagnetic fields can be redirected at will and propose a design strategy. The conserved fields—electric displacement field D , magnetic induction field B , and Poynting vector B —are all displaced in a consistent manner. A simple illustration is ... | 10.1038/s42254-023-00565-4 | This study used coordinate transformations to design an optical cloak, which, together with ref. 3 , opens up the field of transformation optics. |
10.1126/science.1126493 | 83,288,410 | An invisibility device should guide light around an object as if nothing were there, regardless of where the light comes from. Ideal invisibility devices are impossible, owing to the wave nature of light. This study develops a general recipe for the design of media that create perfect invisibility within the accuracy o... | 10.1038/s42254-023-00565-4 | This study used conformal mapping to design an optical cloak, which, together with ref. 1 , opens up the field of transformation optics. |
10.1126/science.1246545 | 124,923,217 | The area of metamaterials may expand to find application in mechanics, acoustics, and thermodynamics. | 10.1038/s42254-023-00565-4 | This work clarified the physical mechanisms of thermal diffusion metamaterials by defining the characteristic length as thermal diffusion lengths, which differ from the incident wavelengths of wave metamaterials. |
10.1098/rsif.2013.0106 | 19,363,802 | Here, we adapt the concept of transformational thermodynamics, whereby the flux of temperature is controlled via anisotropic heterogeneous diffusivity, for the diffusion and transport of mass concentration. The n -dimensional, time-dependent, anisotropic heterogeneous Fick's equation is considered, which is a parabolic... | 10.1038/s42254-023-00565-4 | This work designed particle diffusion cloaks based on transformation theory. |
10.1063/1.2951600 | 62,575,225 | Based on a first-principles approach, we exploit a class of shaped graded materials in which thermal energy is apparently controlled to transfer from a region of lower temperature to a region of higher temperature. This phenomenon, which is in contrast to our common intuition, is indicative of an apparent negative ther... | 10.1038/s42254-023-00565-4 | This article proposes transformation thermotics (for steady-state thermal conduction), thus beginning the research on (thermal) diffusion metamaterials. |
10.1063/1.2988181 | 4,788,673 | We explore the possibility to cloak a region in curvilinearly anisotropic background materials in the context of conductivity. Materials with curvilinear anisotropy possess constant properties in specific curvilinear coordinate. For cylindrically and spherically anisotropic solids, the cloak center and the origin of ma... | 10.1038/s42254-023-00565-4 | This work developed the transformation thermotics theory for designing thermal cloaks in an anisotropic background medium. |
10.1063/1.3490226 | 60,982,175 | We theoretically explore a type of bifunctional cloak possessing both electrical and thermal cloaking functionality. We employ a composite material to design the cloak shell. By using effective medium theory, the effective electrical and thermal conductivities of the composite material should meet the perfect conductiv... | 10.1038/s42254-023-00565-4 | This study designed multiphysics metamaterials to simultaneously achieve thermal and electrical cloaking. |
10.1126/science.aaw6259 | 134,224,162 | Making heat stand still Dissipative oscillating systems (waves) can be described mathematically in terms of non-Hermitian physics. When parity-time symmetric systems have dissipative components, the interplay between gain and loss can lead to unusual and exotic behavior. Li et al. show theoretically and demonstrate exp... | 10.1038/s42254-023-00565-4 | This work reports anti-parity–time symmetry in heat diffusion systems and proposes the concept of non-Hermitian thermotics. |
10.1126/science.1150878 | 62,203,059 | We developed a chemical route to produce graphene nanoribbons (GNR) with width below 10 nanometers, as well as single ribbons with varying widths along their lengths or containing lattice-defined graphene junctions for potential molecular electronics. The GNRs were solution-phase–derived, stably suspended in solvents w... | 10.1038/s42254-021-00370-x | Demonstration of sub-10-nm-wide GNRs using chemical sonication and field-effect transistors with high on/off ratio of 10 7 at room temperature |
10.1002/adma.202001893 | 41,657,589 | Abstract Graphene nanoribbons (GNRs) are quasi‐1D graphene strips, which have attracted attention as a novel class of semiconducting materials for various applications in electronics and optoelectronics. GNRs exhibit unique electronic and optical properties, which sensitively depend on their chemical structures, especi... | 10.1038/s42254-021-00370-x | A comprehensive overview of the synthesis of GNRs on metal surface and devices studies for transistor applications |
10.1126/science.abb8880 | 62,121,280 | Atomically precise graphene nanoribbons (GNRs) attract great interest because of their highly tunable electronic, optical, and transport properties. However, on-surface synthesis of GNRs is typically based on metal surface–assisted chemical reactions, where metallic substrates strongly screen their designer electronic ... | 10.1038/s42254-021-00370-x | Report of bottom-up assembly of GNRs directly on oxide (non-metal) surfaces |
10.1038/ncomms9006 | 20,002,072 | Abstract Graphene can be transformed from a semimetal into a semiconductor if it is confined into nanoribbons narrower than 10 nm with controlled crystallographic orientation and well-defined armchair edges. However, the scalable synthesis of nanoribbons with this precision directly on insulating or semiconducting subs... | 10.1038/s42254-021-00370-x | Work reporting the production of AGNR on technologically relevant germanium wafer |
10.1038/ncomms14703 | 20,364,619 | Abstract Graphene nanoribbons (GNRs) are ultra-narrow strips of graphene that have the potential to be used in high-performance graphene-based semiconductor electronics. However, controlled growth of GNRs on dielectric substrates remains a challenge. Here, we report the successful growth of GNRs directly on hexagonal b... | 10.1038/s42254-021-00370-x | Report on the fabrication of sub-10-nm-wide GNRs embedded in the top layer of h -BN crystal with high chemical and mechanical stability |
10.1038/s41467-021-27454-7 | 133,457,475 | Abstract The emerging threat of atmospheric microplastic pollution has prompted researchers to study areas previously considered beyond the reach of plastic. Investigating the range of atmospheric microplastic transport is key to understanding the global extent of this problem. While atmospheric microplastics have been... | 10.1038/s43017-022-00292-x | This is a remote-area atmospheric MP quantification and modelling study, illustrating marine sources relative to the specific study site and duration |
10.1038/s41467-020-17201-9 | 20,420,077 | Abstract In recent years, marine, freshwater and terrestrial pollution with microplastics has been discussed extensively, whereas atmospheric microplastic transport has been largely overlooked. Here, we present global simulations of atmospheric transport of microplastic particles produced by road traffic (TWPs – tire w... | 10.1038/s43017-022-00292-x | Together with Brahney et al. (2021), this study models the global atmospheric flux of MP and considers the uncertainty in atmospheric MP flux estimation |
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