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PMC12507069 | core_pubmed_pmc | Molecular Docking and Dynamic Studies of Chlorogenic Acid Isomers as Antagonists of p53 Transcription Factor for Potential Adjuvant Radiotherapy | Molecular Docking and Dynamic Studies of Chlorogenic Acid Isomers as Antagonists of p53 Transcription Factor for Potential Adjuvant Radiotherapy Abstract Objective: Chlorogenic acids (CGAs) are among potential natural radioprotectant for inhibiting inappropriate p53 activation of adjacent normal tissues upon radiothera... |
PMC8553450 | core_pubmed_pmc | Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs | Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs Abstract Artemisinin-hydroxychloroquine sulfate tablets (AH) are relatively inexpensive and a novel combination therapy for the treatment of all forms of malaria, especially aminoquinine drug-resistant strains of P. f... |
PMC8231382 | core_pubmed_pmc | Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care | Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care Abstract Abstract Many patients with type 2 diabetes will ultimately require the inclusion of basal insulin in their treatment regimen. Since most people with type 2 diabetes are managed in the communit... |
PMC11389879 | core_pubmed_pmc | Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled Δ9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users | Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled Δ9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users Abstract Supplemental Digital Content is Available in the Text. Background: Unusually high variability in blood Δ9-tetrahydrocannabinol (THC) concentrations have bee... |
PMC12584182 | core_pubmed_pmc | Stenotrophomonas maltophilia : the need for randomized controlled trials to evaluate treatment options | Stenotrophomonas maltophilia : the need for randomized controlled trials to evaluate treatment options Abstract ABSTRACT The most optimal treatment for serious Stenotrophomonas maltophilia infections remains undetermined based on current evidence. The evolution of Infectious Diseases Society of America (IDSA) guidance ... |
PMC6689996 | core_pubmed_pmc | Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear | Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear Abstract Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolo... |
PMC12686613 | core_pubmed_pmc | Critical quality attributes of lipid nanoparticles and in vivo fate | Critical quality attributes of lipid nanoparticles and in vivo fate Abstract Abstract Lipid nanoparticles (LNPs) have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs, offering desired benefits for therapeutic applications. Optimization of the treatment efficacy of nanocarrie... |
PMC4984427 | core_pubmed_pmc | Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users | Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users Abstract Abstract Objectives . A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the tre... |
PMC10444713 | core_pubmed_pmc | Celecoxib Oral Solution and the Benefits of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Technology: A Narrative Review | Celecoxib Oral Solution and the Benefits of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Technology: A Narrative Review Abstract Introduction The oral route of drug delivery is the most widespread and preferred route of administration, but it has several limitations, including variable pharmacokinetics (PK), re... |
PMC9572066 | core_pubmed_pmc | Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of Acanthamoeba Keratitis | Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of Acanthamoeba Keratitis Abstract Abstract Acanthamoeba species are capable of causing amoebic keratitis (AK). As a monotherapy, alpha-mangostin is effective for the treat... |
PMC11286589 | core_pubmed_pmc | Population pharmacokinetics and exposure–response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer | Population pharmacokinetics and exposure–response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer Abstract Abstract Objective SAF-189s is a potent ALK/ROS1 inhibitor that is currently in clinical development for treating advanced ALK+/ROS1+ non-small cell lung cancer (NSCLC). Compreh... |
PMC6162918 | core_pubmed_pmc | Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol | Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol Abstract Abstract Background An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact o... |
PMC11816975 | core_pubmed_pmc | Bioactive Peptides from Milk Proteins with Antioxidant, Anti-Inflammatory, and Antihypertensive Activities | Bioactive Peptides from Milk Proteins with Antioxidant, Anti-Inflammatory, and Antihypertensive Activities Abstract Background/Objectives: Peptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effec... |
PMC8821864 | core_pubmed_pmc | Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions | Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions Abstract Abstract In vitro screening for pharmacological activity of existing drugs showed chloroquine and hydroxychloroquine to be effective against severe acute respiratory synd... |
PMC10799649 | core_pubmed_pmc | Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder | Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder Abstract Abstract Background Viloxazine ER (viloxazine extended-release capsules; Qelbree ® ), a nonstimulant attentio... |
PMC8218697 | core_pubmed_pmc | A pharmacokinetics–pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats | A pharmacokinetics–pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats Abstract Abstract Context Total Glucosides of Paeony (TGP) capsule possesses various hepatoprotective activities. No study is available concerning TGP’s concentration–effe... |
PMC11858958 | core_pubmed_pmc | Exploratory Study on Nanoparticle Co-Delivery of Temozolomide and Ligustilide for Enhanced Brain Tumor Therapy | Exploratory Study on Nanoparticle Co-Delivery of Temozolomide and Ligustilide for Enhanced Brain Tumor Therapy Abstract Background: Temozolomide (TMZ) is the first-line therapy for glioblastoma (GBM), but its clinical efficacy is limited by its short half-life, poor brain targeting, adverse side effects, and the develo... |
PMC5351003 | core_pubmed_pmc | Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 ( CES1 ) Variants | Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 ( CES1 ) Variants Abstract The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain ... |
PMC8241492 | core_pubmed_pmc | Timing HIV infection with a simple and accurate population viral dynamics model | Timing HIV infection with a simple and accurate population viral dynamics model Abstract Clinical trials for HIV prevention can require knowledge of infection times to subsequently determine protective drug levels. Yet, infection timing is difficult when study visits are sparse. Using population nonlinear mixed-effects... |
PMC12007624 | core_pubmed_pmc | Dolutegravir-based Antiretroviral Therapy in People With HIV With Solid Organ Transplantation: A Single-arm Pilot Clinical Trial (DTG-SOT) | Dolutegravir-based Antiretroviral Therapy in People With HIV With Solid Organ Transplantation: A Single-arm Pilot Clinical Trial (DTG-SOT) Abstract Abstract Background This study assessed the pharmacokinetic interactions between dolutegravir (DTG)-based antiretroviral therapy (ART) and immunosuppressants in solid organ... |
PMC12030442 | core_pubmed_pmc | Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood | Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood Abstract Background/Objectives : Agarwood has a good neuroprotective effect and is often used to relieve anxiety and treat insomnia. This study compared the similarities and differences in... |
PMC7256776 | core_pubmed_pmc | Pharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches | Pharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches Abstract Farfarae flos (FF) is widely used for cough over thousands of years in China, but little is known about their pharmacokinetics properties. ... |
PMC6561612 | core_pubmed_pmc | Complex Bayesian Modeling Workflows Encoding and Execution Made Easy With a Novel WinBUGS Plugin of the Drug Disease Model Resources Interoperability Framework | Complex Bayesian Modeling Workflows Encoding and Execution Made Easy With a Novel WinBUGS Plugin of the Drug Disease Model Resources Interoperability Framework Abstract The Drug Disease Model Resources (DDMoRe) Interoperability Framework (IOF) enables pharmacometric model encoding and execution via Model Description La... |
PMC7062083 | core_pubmed_pmc | Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate | Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate Abstract ET-26-HCl, a novel anaesthetic agent with promising pharmacological properties, lacks extensive studies on pharmacokinetics and disposition in vitro and in vivo . In this ... |
PMC3996367 | core_pubmed_pmc | Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery | Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery Abstract Abstract Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cel... |
PMC9633469 | core_pubmed_pmc | Combined Semi-mechanistic Target-Mediated Drug Disposition and Pharmacokinetic–Pharmacodynamic Models of Alirocumab, PCSK9, and Low-Density Lipoprotein Cholesterol in a Pooled Analysis of Randomized Phase I/II/III Studies | Combined Semi-mechanistic Target-Mediated Drug Disposition and Pharmacokinetic–Pharmacodynamic Models of Alirocumab, PCSK9, and Low-Density Lipoprotein Cholesterol in a Pooled Analysis of Randomized Phase I/II/III Studies Abstract Abstract Background and Objectives Alirocumab is a cholesterol-lowering monoclonal antibo... |
PMC7612724 | core_pubmed_pmc | Validation and Clinical Application of a Liquid Chromatography-Ultraviolet Detection Method to Quantify Dolutegravir in Dried Blood Spots | Validation and Clinical Application of a Liquid Chromatography-Ultraviolet Detection Method to Quantify Dolutegravir in Dried Blood Spots Abstract Abstract Background Dolutegravir is currently the preferred component of first-line antiretroviral therapy. To facilitate clinical pharmacology studies in key populations, q... |
PMC12276660 | core_pubmed_pmc | Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials | Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials Abstract Background Chronic obstructive pulmonary disease (COPD), the third leading cause of global mortality, remains a significant challenge in long-term management. ... |
PMC5240302 | core_pubmed_pmc | Anti-staphylococcal activity resulting from epithelial lining fluid (ELF) concentrations of amikacin inhale administered via the pulmonary drug delivery system | Anti-staphylococcal activity resulting from epithelial lining fluid (ELF) concentrations of amikacin inhale administered via the pulmonary drug delivery system Abstract Background Amikacin inhale (BAY41-6551), a unique drug—device combination of a specially formulated drug solution and a pulmonary drug delivery system ... |
PMC7470854 | core_pubmed_pmc | Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China | Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China Abstract Abstract Atypical antipsychotics exert remarkable long-term efficacy on the personal and social functions of schizophrenic patients. However, quantitative information on the social function of schizophreni... |
PMC12080763 | core_pubmed_pmc | Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy | Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy Abstract Abstract Fc fusion proteins, formed by fusing an active protein to the Fc region of immunoglobulin G, are a validated strategy for extending the half-life ... |
PMC12479639 | core_pubmed_pmc | Clinical Pharmacology Profile of the Claudin 18.2 Antibody Zolbetuximab | Clinical Pharmacology Profile of the Claudin 18.2 Antibody Zolbetuximab Abstract Abstract Zolbetuximab is a first-in-class chimeric (mouse/human) monoclonal antibody targeted to the tight junction protein claudin 18.2 (CLDN18.2), an emerging biomarker in gastric/gastroesophageal junction (G/GEJ) cancer. This review sum... |
PMC10129904 | core_pubmed_pmc | Interactions of Antiretroviral Drugs with Food, Beverages, Dietary Supplements, and Alcohol: A Systematic Review and Meta-analyses | Interactions of Antiretroviral Drugs with Food, Beverages, Dietary Supplements, and Alcohol: A Systematic Review and Meta-analyses Abstract Multiple factors may affect combined antiretroviral therapy (cART). We investigated the impact of food, beverages, dietary supplements, and alcohol on the pharmacokinetic and pharm... |
PMC10583688 | core_pubmed_pmc | Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis | Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis Abstract ABSTRACT Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The current regimen that is standard-of-care involves a combination of three different drugs administered for up t... |
PMC6617763 | core_pubmed_pmc | What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics? | What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics? Abstract Abstract Asparagus consumption is associated with the production of malodorous urine. Interindividual variability was previously characterized by an American Society for Clinical Pharmacology and Therapeutics crowdsourced study. ... |
PMC12948610 | core_pubmed_pmc | Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making | Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making Abstract Background Anticoagulation in atrial fibrillation often relies on a fixed dose and infrequent dose adjustment and does not incorporate patient preferences for risks of stroke, bleeding, and death. Objectives We... |
PMC9216474 | core_pubmed_pmc | Translational drug–interaction corpus | Translational drug–interaction corpus Abstract Abstract The discovery of drug–drug interactions (DDIs) that have a translational impact among in vitro pharmacokinetics (PK), in vivo PK and clinical outcomes depends largely on the quality of the annotated corpus available for text mining. We have developed a new DDI cor... |
PMC4338618 | core_pubmed_pmc | Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy | Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy Abstract Introduction Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxi... |
PMC4243578 | core_pubmed_pmc | A Phase 2 Study of Abiraterone Acetate in Japanese Men with Metastatic Castration-resistant Prostate Cancer Who Had Received Docetaxel-based Chemotherapy | A Phase 2 Study of Abiraterone Acetate in Japanese Men with Metastatic Castration-resistant Prostate Cancer Who Had Received Docetaxel-based Chemotherapy Abstract Objective In this Phase 2 multicenter study the efficacy and safety of oral abiraterone acetate (1000 mg/once daily) plus prednisolone (5 mg/twice daily) was... |
PMC10514878 | core_pubmed_pmc | Effects of Transition from Closed-Book to Open-Book Assessment on Students’ Scores in a Pharmacokinetics Course | Effects of Transition from Closed-Book to Open-Book Assessment on Students’ Scores in a Pharmacokinetics Course Abstract Abstract Closed-book summative assessment of student learning, common in pharmacy education, is challenging to administer in a remote setting due to the need for costly and intrusive monitoring techn... |
PMC8718750 | core_pubmed_pmc | Cerebral Oxygenation and Activity During Surgical Repair of Neonates With Congenital Diaphragmatic Hernia: A Center Comparison Analysis | Cerebral Oxygenation and Activity During Surgical Repair of Neonates With Congenital Diaphragmatic Hernia: A Center Comparison Analysis Abstract Abstract Background and aim: Neonatal brain monitoring is increasingly used due to reports of brain injury perioperatively. Little is known about the effect of sedatives (mida... |
PMC9756572 | core_pubmed_pmc | A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products | A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products Abstract Abstract Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict dru... |
PMC6150312 | core_pubmed_pmc | Simultaneous Determination of Seven Anthraquinone Aglycones of Crude and Processed Semen Cassiae Extracts in Rat Plasma by UPLC–MS/MS and Its Application to a Comparative Pharmacokinetic Study | Simultaneous Determination of Seven Anthraquinone Aglycones of Crude and Processed Semen Cassiae Extracts in Rat Plasma by UPLC–MS/MS and Its Application to a Comparative Pharmacokinetic Study Abstract Abstract Semen cassiae is the ripe seed of Cassia obtusifolia L. or Cassia tora L. of the family Leguminosae. In tradi... |
PMC12370499 | core_pubmed_pmc | Optimizing anti-thymocyte globulin dosing in allogeneic hematopoietic stem cell transplantation: individualized approaches and clinical implications | Optimizing anti-thymocyte globulin dosing in allogeneic hematopoietic stem cell transplantation: individualized approaches and clinical implications Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematologic malignancies. However, the initial clinical exper... |
PMC4360665 | core_pubmed_pmc | Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants | Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants Abstract Abstract This study describes the maturation of sirolimus clearance in a cohort of very young pediatric patients with vascular anomalies. The relationship b... |
PMC6752828 | core_pubmed_pmc | Oral dosing for antenatal corticosteroids in the Rhesus macaque | Oral dosing for antenatal corticosteroids in the Rhesus macaque Abstract Antenatal corticosteroids (ACS) are standard of care for women at risk of preterm delivery, although choice of drug, dose or route have not been systematically evaluated. Further, ACS are infrequently used in low resource environments where most o... |
PMC7816977 | core_pubmed_pmc | Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In - vitro evaluation, optimization and physiologically based pharmacokinetic modeling | Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In - vitro evaluation, optimization and physiologically based pharmacokinetic modeling Abstract Abstract Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited bioavailability. Solid dispers... |
PMC8359231 | core_pubmed_pmc | Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID‐19 Therapeutic Development | Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID‐19 Therapeutic Development Abstract Abstract The urgent global public health need presented by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) has brought scientists from diverse backgrounds toge... |
PMC6761554 | core_pubmed_pmc | Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction | Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction Abstract Evaluation of dosing regimens for critically ill patients requires pharmacokinetic data in this population. This prospective observational study aimed to describe the population pharmacokineti... |
PMC8140898 | core_pubmed_pmc | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis Abstract Abstract Background To establish a novel delivery system of pemirolast potassium-loaded gellan gum in situ gel in allergic conjunctivitis therapy. Methods The prepared in situ gels were studied in the ... |
PMC7407196 | core_pubmed_pmc | Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents | Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents Abstract Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX. The last three decades have witnessed a sudden bo... |
PMC9996380 | core_pubmed_pmc | Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B | Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B Abstract Gene therapy of Usher syndrome type 1B (USH1B) due to mutations in the large Myosin VIIA ( MYO7A ) gene is limited by the packaging capacity of adeno-associated viral (AAV) vectors. To overcome... |
PMC5400625 | core_pubmed_pmc | Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer | Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Abstract Rac GTPases have oncogenic roles in cell growth, survival, and migration. We tested response to the Rac inhibitor EHT1864 in a panel of breast cancer cell lines. EHT1864-induce... |
PMC9478743 | core_pubmed_pmc | Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance | Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance Abstract In recent decades, research scientists, molecular biologists, and pharmacologists have placed a strong emphasis on cutting-edge nanostructured materials technologies to increase medicine delivery... |
PMC10339696 | core_pubmed_pmc | In vivo tissue pharmacokinetics of ERBB2‐specific binding oligonucleotide‐based drugs by PET imaging | In vivo tissue pharmacokinetics of ERBB2‐specific binding oligonucleotide‐based drugs by PET imaging Abstract Abstract Although aptamers have shown excellent target specificity in preclinical and clinical studies either by themselves or as aptamer‐drug conjugates, their in vivo tissue pharmacokinetic (PK) analysis is s... |
PMC6492074 | core_pubmed_pmc | Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative | Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative Abstract Abstract The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the Comprehensive In Vi... |
PMC12087767 | core_pubmed_pmc | Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended‐Gate Field‐Effect‐Transistor Biosensors | Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended‐Gate Field‐Effect‐Transistor Biosensors Abstract The selection and optimization of therapies for cancer patients urgently need personalization. Portable point‐of‐care electronic biosensors emerge as a groundbreaking solution contributing to... |
PMC9506044 | core_pubmed_pmc | Identification of Protosappanoside D from Caesalpinia decapetala and Evaluation of Its Pharmacokinetic, Metabolism and Pharmacological Activity | Identification of Protosappanoside D from Caesalpinia decapetala and Evaluation of Its Pharmacokinetic, Metabolism and Pharmacological Activity Abstract Abstract Protosappanoside D (PTD) is a new component isolated from the extract of Caesalpinia decapetala for the first time. Its structure was identified as protosappa... |
PMC10674418 | core_pubmed_pmc | The FDA’s New Guideline “Generally Accepted Scientific Knowledge” (GASK): An Opportunity to Expedite the Approval of Biosimilars | The FDA’s New Guideline “Generally Accepted Scientific Knowledge” (GASK): An Opportunity to Expedite the Approval of Biosimilars Abstract Abstract The US FDA’s new guideline suggests using “Generally Accepted Science Knowledge” (GASK) to develop nonclinical testing protocols for developing drugs and biologicals to remo... |
PMC9349153 | core_pubmed_pmc | Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study | Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study Abstract Background and Objective Ciprofloxacin is a fluoroquinolone used for empirical and targeted therapy of a wide range of infections. Despite the increase in obesity... |
PMC12473779 | core_pubmed_pmc | Indirect Modeling of Post-Prandial Intestinal Lymphatic Uptake of Halofantrine Using PBPK Approaches: Limitations and Implications | Indirect Modeling of Post-Prandial Intestinal Lymphatic Uptake of Halofantrine Using PBPK Approaches: Limitations and Implications Abstract Abstract Background/Objectives: Despite the recognized importance and distinctive characteristics of the intestinal lymphatic pathway in drug absorption, its pharmacokinetic modeli... |
PMC8226118 | core_pubmed_pmc | A Regression Model to Predict Augmented Renal Clearance in Critically Ill Obstetric Patients and Effects on Vancomycin Treatment | A Regression Model to Predict Augmented Renal Clearance in Critically Ill Obstetric Patients and Effects on Vancomycin Treatment Abstract Background: Augmented renal clearance (ARC) risk factors and effects on vancomycin (VCM) of obstetric patients were possibly different from other populations based on pathophysiologi... |
PMC12745394 | core_pubmed_pmc | Remimazolam in pediatric ambulatory anesthesia: a critical review and clinical perspective | Remimazolam in pediatric ambulatory anesthesia: a critical review and clinical perspective Abstract The management of anesthesia for pediatric day surgery demands rapid onset, precise control, and predictable recovery. Remimazolam, an ultrashort-acting benzodiazepine with esterase-dependent metabolism, theoretically me... |
PMC11693943 | core_pubmed_pmc | Dosing Regimen Recommendations for Sirolimus in Adult Liver Transplant Recipients: Insights from a Population Pharmacokinetic Model | Dosing Regimen Recommendations for Sirolimus in Adult Liver Transplant Recipients: Insights from a Population Pharmacokinetic Model Abstract Abstract Background Sirolimus is a commonly used immunosuppressant administered after solid organ transplantation. It is characterized by a narrow therapeutic window and highly va... |
PMC9070076 | core_pubmed_pmc | An integrated pharmacokinetic study of Dengzhanxixin injection in rats by combination of multicomponent pharmacokinetics and anti-myocardial ischemic assay † | An integrated pharmacokinetic study of Dengzhanxixin injection in rats by combination of multicomponent pharmacokinetics and anti-myocardial ischemic assay † Abstract Abstract This study aimed to investigate the integrated pharmacokinetics (PK) of Dengzhanxixin injection (EBI) in rats by combination of multicomponent P... |
PMC12056914 | core_pubmed_pmc | In silico study of the potential of curcumin and its derivatives for increasing wild-type p53 expression and improving the function of p53 mutant R273H | In silico study of the potential of curcumin and its derivatives for increasing wild-type p53 expression and improving the function of p53 mutant R273H Abstract Background and Aim: p53 is a critical tumor suppressor protein responsible for regulating the cell cycle and inducing apoptosis. Mutations in the p53 gene, par... |
PMC10619513 | core_pubmed_pmc | Closed-loop control of anesthetic state in nonhuman primates | Closed-loop control of anesthetic state in nonhuman primates Abstract Abstract Research in human volunteers and surgical patients has shown that unconsciousness under general anesthesia can be reliably tracked using real-time electroencephalogram processing. Hence, a closed-loop anesthesia delivery (CLAD) system that m... |
PMC8078322 | core_pubmed_pmc | Cardiac Safety of Osimertinib: A Review of Data | Cardiac Safety of Osimertinib: A Review of Data Abstract PURPOSE Osimertinib is a third-generation, CNS-active, irreversible, oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that potently and selectively inhibits both EGFR-TKI-sensitizing and T790M resistance mutations. We assess the cardiac ... |
PMC10582655 | core_pubmed_pmc | Associations of HLA‐C*01:02 and HLA‐B*46:01 with regorafenib‐induced erythema multiforme in Japanese patients with metastatic colorectal cancer | Associations of HLA‐C*01:02 and HLA‐B*46:01 with regorafenib‐induced erythema multiforme in Japanese patients with metastatic colorectal cancer Abstract Abstract Regorafenib improves the survival of patients with metastatic colorectal cancer (mCRC); however, it is also characterized by detrimental dermal side effects t... |
PMC11546702 | core_pubmed_pmc | Novel 1,8-Naphthalimide Derivatives Inhibit Growth and Induce Apoptosis in Human Glioblastoma | Novel 1,8-Naphthalimide Derivatives Inhibit Growth and Induce Apoptosis in Human Glioblastoma Abstract Abstract Given the rapid advancement of functional 1,8-Naphthalimide derivatives in anticancer research, we synthesized these two novel naphthalimide derivatives with diverse substituents and investigated the effect o... |
PMC4234452 | core_pubmed_pmc | Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2 | Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2 Abstract Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the posttranslational modification of glutamine residues on protein or peptide substrates. A growing body of literature has implicated aberrantly r... |
PMC10264686 | core_pubmed_pmc | Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma | Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma Abstract In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatini... |
PMC11162477 | core_pubmed_pmc | Modulation of serotonin transporter expression by escitalopram under inflammation | Modulation of serotonin transporter expression by escitalopram under inflammation Abstract Selective serotonin reuptake inhibitors (SSRIs) are widely used for depression based on the monoamine deficiency hypothesis. However, the clinical use of these agents is controversial, in part because of their variable clinical e... |
PMC6271986 | core_pubmed_pmc | LC-ESI-MS/MS Analysis and Pharmacokinetics of Plantainoside D Isolated from Chirita longgangensis var. hongyao , a Potential Anti-Hypertensive Active Component in Rats | LC-ESI-MS/MS Analysis and Pharmacokinetics of Plantainoside D Isolated from Chirita longgangensis var. hongyao , a Potential Anti-Hypertensive Active Component in Rats Abstract Plantainoside D (PD) is a potential anti-hypertensive active ingredient newly isolated from the dried plants of Chirita longgangensis var. hong... |
PMC10126473 | core_pubmed_pmc | Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug | Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug Abstract Abstract Introduction: Niclosamide (Nc) is an FDA-approved anthelmintic drug that was recently identified in a drug repurposing screening to posses... |
PMC4888587 | core_pubmed_pmc | Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study | Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study Abstract Background The cost and complexity of current approaches to therapeutic drug monitoring during tuberculosis (TB) therapy limits widespread use in areas of greatest need. We sought to determine whether urine ... |
PMC12737318 | core_pubmed_pmc | Therapeutic Delivery of Phloretin by Mixed Emulsifier-Stabilized Nanoemulsion Alleviated Cerebral Ischemia/Reperfusion Injury | Therapeutic Delivery of Phloretin by Mixed Emulsifier-Stabilized Nanoemulsion Alleviated Cerebral Ischemia/Reperfusion Injury Abstract Background: Cerebral ischemia/reperfusion injury (CIRI) is a major challenge in ischemic stroke treatment. Phloretin (PHL), despite its potent antioxidant and anti-inflammatory properti... |
PMC6397271 | core_pubmed_pmc | Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin | Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin Abstract In the presented study, transportan 10 (TP10), an amphipathic cell penetrating peptide (CPP) with high translocation activity, was conjugated with vancomycin (Van), which is known for poor access to the intracellular bacteria and t... |
PMC8127508 | core_pubmed_pmc | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial Abstract Abstracts Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147... |
PMC4811842 | core_pubmed_pmc | Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo | Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo Abstract Abstract Aim To evaluate whether berberine hydrochloride (BBR) could modify the pharmacokinetic profiles of midazolam (MDZ), a substrate of CYP3A, and rhodamine 123 (Rh123), a substrate of P-glycolprotein (P-gp), in male ra... |
PMC8047500 | core_pubmed_pmc | The gut microbiome influences the bioavailability of olanzapine in rats | The gut microbiome influences the bioavailability of olanzapine in rats Abstract Abstract Background The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration ... |
PMC6871266 | core_pubmed_pmc | Electroencephalographic slow wave dynamics and loss of behavioural responsiveness induced by ketamine in human volunteers | Electroencephalographic slow wave dynamics and loss of behavioural responsiveness induced by ketamine in human volunteers Abstract Abstract Background Previous work on the electroencephalographic (EEG) effects of anaesthetic doses of ketamine has identified a characteristic signature of increased high frequency (beta–g... |
PMC7015754 | core_pubmed_pmc | Population pharmacokinetics of a triple‐secured fibrinogen concentrate administered to afibrinogenaemic patients: Observed age‐ and body weight‐related differences and consequences for dose adjustment in children | Population pharmacokinetics of a triple‐secured fibrinogen concentrate administered to afibrinogenaemic patients: Observed age‐ and body weight‐related differences and consequences for dose adjustment in children Abstract Aims The pharmacokinetics (PK) of a triple‐secured fibrinogen concentrate (FC) was assessed in pat... |
PMC5770454 | core_pubmed_pmc | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling Abstract The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study repor... |
PMC6765699 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction | Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction Abstract Physiologically‐based pharmacokinetic ( PBPK ) modeling is a powerful tool to quantitatively describe drug disposition profiles in vivo , thereby providing an alternative to predict drug–dru... |
PMC3706890 | core_pubmed_pmc | Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 | Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 Abstract Background Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1 ) mediate the hepatic uptake of endogenous compounds like bile a... |
PMC11254780 | core_pubmed_pmc | PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies | PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies Abstract Abstract The urgent need for safe, efficacious, and accessible drug treatments to treat coronavirus disease 2019 (COVID‐19) prompted a global effort to evaluate... |
PMC3041204 | core_pubmed_pmc | Accelerated Insulin Pharmacokinetics and Improved Postprandial Glycemic Control in Patients With Type 1 Diabetes After Coadministration of Prandial Insulins With Hyaluronidase | Accelerated Insulin Pharmacokinetics and Improved Postprandial Glycemic Control in Patients With Type 1 Diabetes After Coadministration of Prandial Insulins With Hyaluronidase Abstract OBJECTIVE To compare the pharmacokinetics, pharmacodynamics, and safety of insulin lispro or regular human insulin (RHI) with or withou... |
PMC7683227 | core_pubmed_pmc | Dataset of potential Rhizoma Polygonati compound-druggable targets and partial pharmacokinetics for treatment of COVID-19 | Dataset of potential Rhizoma Polygonati compound-druggable targets and partial pharmacokinetics for treatment of COVID-19 Abstract Abstract Rhizoma Polygonati (Chinese name as 黄精, pinyin as huangjing), as medicine and food homology of Traditional Chinese Medicine, has been recently applied for the complex prescriptions... |
PMC6510381 | core_pubmed_pmc | Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment | Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment Abstract Abstract Sparse data exist on the penetration of antiretrovirals into brain tissue. In this work, we present a framework to use efavirenz (EFV) pharmacokinetic (PK) ... |
PMC9016780 | core_pubmed_pmc | Polysaccharide Peptide Extract From Coriolus versicolor Increased T max of Tamoxifen and Maintained Biochemical Serum Parameters, With No Change in the Metabolism of Tamoxifen in the Rat | Polysaccharide Peptide Extract From Coriolus versicolor Increased T max of Tamoxifen and Maintained Biochemical Serum Parameters, With No Change in the Metabolism of Tamoxifen in the Rat Abstract Background: Polysaccharide peptide (PSP) extract of Coriolus versicolor (L.) Quél. (1886) ( Trametes ; Polyporaceae) is incr... |
PMC11859824 | core_pubmed_pmc | Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption | Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption Abstract Abstract Background/Objectives : Omeprazole undergoes degradation in acidic conditions, which makes it unstable in low pHs found in the gastric environment. The vast majority of already marketed omeprazole formulations use enteric polyme... |
PMC7848043 | core_pubmed_pmc | Effects of the reservoir bag disconnection on inspired gases during general anesthesia: a simulator-based study | Effects of the reservoir bag disconnection on inspired gases during general anesthesia: a simulator-based study Abstract Abstract Background Fresh gas decoupling is a feature of the modern anesthesia workstation, where the fresh gas flow (FGF) is diverted into the reservoir bag and is not added to the delivered tidal v... |
PMC11423471 | core_pubmed_pmc | Continuous sampling of healthy and mastitic quarters of lactating cattle by ultrafiltration after intramammary ceftiofur hydrochloride administration | Continuous sampling of healthy and mastitic quarters of lactating cattle by ultrafiltration after intramammary ceftiofur hydrochloride administration Abstract Abstract Background Pharmacological activity of intramammary drugs depends on adequate drug concentrations within the cistern, but sampling is often limited. Ins... |
PMC8103205 | core_pubmed_pmc | Disease Status–Dependent Drug–Herb Interactions: NASH Lowered the Risk of Hepatotoxicity in Rats Coadministered With Simvastatin and Gardenia jasminoides J. Ellis | Disease Status–Dependent Drug–Herb Interactions: NASH Lowered the Risk of Hepatotoxicity in Rats Coadministered With Simvastatin and Gardenia jasminoides J. Ellis Abstract Abstract Concurrent use of simvastatin (SV) and Gardenia jasminoides J. Ellis (GJ) was adopted in patients with multi-morbidity, such as stroke reha... |
PMC3575217 | core_pubmed_pmc | Double-blind, placebo-controlled, two-period, crossover trial to examine the pharmacokinetics of lisdexamfetamine dimesylate in healthy older adults | Double-blind, placebo-controlled, two-period, crossover trial to examine the pharmacokinetics of lisdexamfetamine dimesylate in healthy older adults Abstract Background Pharmacokinetic and safety data on stimulants in older adults are limited. The objective of this study was to characterize the pharmacokinetics of lisd... |
PMC8309183 | core_pubmed_pmc | Re-Assessing PK/PD Issues for Oral Protein and Peptide Delivery | Re-Assessing PK/PD Issues for Oral Protein and Peptide Delivery Abstract Abstract Due to a lack of safe and effective oral delivery strategies for most protein and peptide therapeutics, pharmaceutical drug developers have focused on parenteral routes to administer these agents. Recent advances in delivery technologies ... |
PMC7502670 | core_pubmed_pmc | Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial | Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial Abstract Background Low-dose interleukin-2 (ld-IL-2) enhances regulatory T-cell (Treg) function in auto-inflammatory conditions. Neuroinflammation being a pathogenic fe... |
PMC12135536 | core_pubmed_pmc | Ex vivo assessment and simulation to guide cefepime-taniborbactam dosing recommendations for patients receiving continuous renal replacement therapy | Ex vivo assessment and simulation to guide cefepime-taniborbactam dosing recommendations for patients receiving continuous renal replacement therapy Abstract ABSTRACT Cefepime-taniborbactam dosing in patients undergoing continuous renal replacement therapy (CRRT) is unknown. We employed an ex vivo CRRT model to charact... |
PMC12064607 | core_pubmed_pmc | Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19 | Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19 Abstract Abstract Background and Objectives There are limited data testing whether the licensed dose of remdesivir and its active metabolite GS-441524 achieve target concentrations in hospitalised pati... |
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