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PMC12199094 | core_pubmed_pmc | Pharmacology and relevant drug interactions of metamizole | Pharmacology and relevant drug interactions of metamizole Abstract Abstract Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical pract... |
PMC7595994 | core_pubmed_pmc | Influence of green tea consumption on endoxifen steady-state concentration in breast cancer patients treated with tamoxifen | Influence of green tea consumption on endoxifen steady-state concentration in breast cancer patients treated with tamoxifen Abstract Abstract Background Many cancer patients use additional herbs or supplements in combination with their anti-cancer therapy. Green tea—active ingredient epigallocatechin-3-gallate (EGCG)—i... |
PMC6635653 | core_pubmed_pmc | Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model | Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model Abstract Abstract Background: Common marmosets ( Callithrix jacchus ) are potentially useful non-human primate models for preclinical studies. Information for major drug-metaboliz... |
PMC9797597 | core_pubmed_pmc | Pharmacokinetics, metabolite profiling, safety, and tolerability of inhalation aerosol of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, in healthy Chinese subjects | Pharmacokinetics, metabolite profiling, safety, and tolerability of inhalation aerosol of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, in healthy Chinese subjects Abstract Abstract 101BHG-D01 is a novel, long-acting, selective muscarinic receptor antagonist for the treatment of chronic... |
PMC6584251 | core_pubmed_pmc | Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab | Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab Abstract Abstract Eculizumab is the first drug approved for the treatment of complement-mediated diseases, and current dosage schedules result in large interindividual drug concentrations. T... |
PMC12844929 | core_pubmed_pmc | Inhibitory Activity of LDT10 and LDT119, New Saturated Cardanols, Against Trypanosoma cruzi | Inhibitory Activity of LDT10 and LDT119, New Saturated Cardanols, Against Trypanosoma cruzi Abstract Abstract Background/Objectives: Chagas disease, caused by Trypanosoma cruzi , remains a major neglected tropical disease with limited therapeutic options restricted to benznidazole and nifurtimox, both associated with s... |
PMC6154618 | core_pubmed_pmc | The Effect and Mechanism of Transdermal Penetration Enhancement of Fu’s Cupping Therapy: New Physical Penetration Technology for Transdermal Administration with Traditional Chinese Medicine (TCM) Characteristics | The Effect and Mechanism of Transdermal Penetration Enhancement of Fu’s Cupping Therapy: New Physical Penetration Technology for Transdermal Administration with Traditional Chinese Medicine (TCM) Characteristics Abstract Abstract Background: In this paper, a new type of physical penetration technology for transdermal a... |
PMC7248054 | core_pubmed_pmc | Pharmacokinetics in children with chronic kidney disease | Pharmacokinetics in children with chronic kidney disease Abstract Abstract In children, the main causes of chronic kidney disease (CKD) are congenital diseases and glomerular disorders. CKD is associated with multiple physiological changes and may therefore influence various pharmacokinetic (PK) parameters. A well-know... |
PMC4745212 | core_pubmed_pmc | Assessment of Pharmacodynamic and Pharmacokinetic Interaction of Aqueous Extract of Cassia auriculata L. and Metformin in Rats | Assessment of Pharmacodynamic and Pharmacokinetic Interaction of Aqueous Extract of Cassia auriculata L. and Metformin in Rats Abstract Background: Cassia auriculata L. (CA) leaf extract might increase the body's production of insulin thereby suppressing the elevated blood glucose and lipid levels in diabetic rats. CA ... |
PMC11479413 | core_pubmed_pmc | Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals | Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals Abstract Abstract Background: Ainuovirine (ANV) is a new generation of non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) type 1 infection. T... |
PMC11430863 | core_pubmed_pmc | pH-Responsive Block Copolymer Micelles of Temsirolimus: Preparation, Characterization and Antitumor Activity Evaluation | pH-Responsive Block Copolymer Micelles of Temsirolimus: Preparation, Characterization and Antitumor Activity Evaluation Abstract Purpose Renal cell carcinoma (RCC) is the most common and lethal type of urogenital cancer, with one-third of new cases presenting as metastatic RCC (mRCC), which, being the seventh most comm... |
PMC5403837 | core_pubmed_pmc | A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer | A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer Abstract Purpose Cabozantinib is a multi-kinase inhibitor that targets MET, AXL, and VEGFR2, and may synergize with EGFR inhibition in NSCLC. Cabozantinib was assessed alone or in combination with erlotinib... |
PMC12814316 | core_pubmed_pmc | Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long‐Acting Intramuscular Injections | Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long‐Acting Intramuscular Injections Abstract Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months re... |
PMC3527585 | core_pubmed_pmc | Dried Whole Plant Artemisia annua as an Antimalarial Therapy | Dried Whole Plant Artemisia annua as an Antimalarial Therapy Abstract Abstract Drugs are primary weapons for reducing malaria in human populations. However emergence of resistant parasites has repeatedly curtailed the lifespan of each drug that is developed and deployed. Currently the most effective anti-malarial is ar... |
PMC4501164 | core_pubmed_pmc | Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis | Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis Abstract Allergic disorders of the ocular surface are primarily characterized as IgE- and/or T-lymphocyte-mediated disorders that affect the cornea, conjunctiva, and eyelid. Approximately 40% of individuals ... |
PMC12650446 | core_pubmed_pmc | Impact of Body Mass Index on Clinical Outcomes in Myocardial Infarction Patients Undergoing Coronary Stenting with Dual Antiplatelet Therapy | Impact of Body Mass Index on Clinical Outcomes in Myocardial Infarction Patients Undergoing Coronary Stenting with Dual Antiplatelet Therapy Abstract Abstract Background : Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 receptor inhibitor (P2Y12i), remains central to the management of acute myocardial ... |
PMC9398478 | core_pubmed_pmc | Suprachoroidal Injection of Triamcinolone Acetonide Suspension: Ocular Pharmacokinetics and Distribution in Rabbits Demonstrates High and Durable Levels in the Chorioretina | Suprachoroidal Injection of Triamcinolone Acetonide Suspension: Ocular Pharmacokinetics and Distribution in Rabbits Demonstrates High and Durable Levels in the Chorioretina Abstract Purpose: To compare ocular pharmacokinetics (PK), systemic absorption, and injectability of triamcinolone acetonide (TA) suprachoroidal (S... |
PMC8331026 | core_pubmed_pmc | Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors | Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors Abstract ABSTRACT Epidermal growth factor receptor (EGFR)-targeted cancer therapy such as anti-EGFR monoclonal antibodies and tyrosine kinase inhibitors have demonstrated clinical efficacy. However, there r... |
PMC9305109 | core_pubmed_pmc | Effect of Anti‐VEGF Therapy on the Disease Progression of Neovascular Age‐Related Macular Degeneration: A Systematic Review and Model‐Based Meta‐Analysis | Effect of Anti‐VEGF Therapy on the Disease Progression of Neovascular Age‐Related Macular Degeneration: A Systematic Review and Model‐Based Meta‐Analysis Abstract Abstract Anti–vascular endothelial growth factor (VEGF) therapy is used to slow the disease progression of neovascular age‐related macular degeneration. Due ... |
PMC4289333 | core_pubmed_pmc | P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer | P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer Abstract Background Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/onco... |
PMC6063742 | core_pubmed_pmc | PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants | PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants Abstract Abstract Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The... |
PMC3020159 | core_pubmed_pmc | Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN) | Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN) Abstract Abstract Background The Worldwide Antimalarial Resistance Network (WWARN) is a global collaboration to support the objective that anyone affected by malaria receives effective and ... |
PMC7293979 | core_pubmed_pmc | Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the treatment of venous thromboembolism | Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the treatment of venous thromboembolism Abstract Abstract Anticoagulant plasma concentrations and patient characteristics might affect the benefit–risk balance of therapy. This study assessed the im... |
PMC7223109 | core_pubmed_pmc | Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity | Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity Abstract Abstract Malaria is one of the major infectious diseases that remains a constant challenge to human being mainly due to the emergence of drug-resistant strains of parasite and also the ... |
PMC7927785 | core_pubmed_pmc | Dexmedetomidine sedation for endobronchial ultrasound-guided transbronchial needle aspiration, a randomised controlled trial | Dexmedetomidine sedation for endobronchial ultrasound-guided transbronchial needle aspiration, a randomised controlled trial Abstract Background and aim Appropriate sedation is important to the success of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Dexmedetomidine is a sedative agent t... |
PMC9323336 | core_pubmed_pmc | Pharmacokinetics and Metabolomic Profiling of Metformin and Andrographis paniculata : A Protocol for a Crossover Randomised Controlled Trial | Pharmacokinetics and Metabolomic Profiling of Metformin and Andrographis paniculata : A Protocol for a Crossover Randomised Controlled Trial Abstract Abstract This protocol aims to profile the pharmacokinetics of metformin and Andrographis paniculata (AP) and continue with untargeted pharmacometabolomics analysis on pr... |
PMC11124818 | core_pubmed_pmc | A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients | A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients Abstract Cystinosis is a rare lysosomal storage disorder caused by autosomal recessive mutations in the CTNS gene that encodes for the cystine transporter cystinosin, which is expressed on the lysosomal membrane med... |
PMC11372057 | core_pubmed_pmc | Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data | Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data Abstract Abstract The selection and combination of dose regimens for antimalarials involve complex considerations including pharmacokinetic and pharmacodynamic interactions. In this study, we use ... |
PMC11815446 | core_pubmed_pmc | Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel | Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel Abstract Abstract Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of cardiovascular diseases. However, clopidogrel responsiveness shows variability ba... |
PMC6973309 | core_pubmed_pmc | VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis | VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis Abstract ABSTRACT CX3CR1 has been identified as a highly attractive target for several therapeutic interventions. Despite this potential, no potent antagonists, either small molecule or monoclonal antibody, have been identified... |
PMC11858597 | core_pubmed_pmc | Synthesis, Anticancer Screening, and In Silico Evaluations of Thieno[2,3- c ]pyridine Derivatives as Hsp90 Inhibitors | Synthesis, Anticancer Screening, and In Silico Evaluations of Thieno[2,3- c ]pyridine Derivatives as Hsp90 Inhibitors Abstract Abstract Background : Thieno[2,3- c ]pyridines and their analogs are not well explored for their anticancer properties. Hence, our research aimed to establish the anticancer potential of thieno... |
PMC8266944 | core_pubmed_pmc | Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation | Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation Abstract Introduction Oral semaglutide is a novel tablet formulation of the human glucagon-like peptide-1 analogue semaglutide. In two trials, the effects of prior food inges... |
PMC8841458 | core_pubmed_pmc | Model‐informed assessment of ethnic sensitivity and dosage justification for Asian populations in the global clinical development and use of cladribine tablets | Model‐informed assessment of ethnic sensitivity and dosage justification for Asian populations in the global clinical development and use of cladribine tablets Abstract Abstract Cladribine tablets have been approved in many countries for the treatment of patients with various forms of relapsing multiple sclerosis (MS).... |
PMC7032219 | core_pubmed_pmc | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo Abstract Abstract The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery sy... |
PMC5044993 | core_pubmed_pmc | Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects | Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects Abstract Aim To determine the effective dose of glibenclamide by quantifying the dose–response relationship in South African type 2 diabetic patients. Patients and methods A total of 24 type 2 diabetic patients p... |
PMC9167390 | core_pubmed_pmc | A Phase I, Open-label, Single-Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of AMG 986 in Healthy Japanese Subjects | A Phase I, Open-label, Single-Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of AMG 986 in Healthy Japanese Subjects Abstract Abstract Background and Objective AMG 986 is a first-in-class, novel apelin receptor small molecule agonist initially developed as a treatment for patients with heart fail... |
PMC10531873 | core_pubmed_pmc | Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios | Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios Abstract It is well established that direct oral anticoagulants (DOACs) are the cornerstone of anticoagulant strategy in atrial fibrillation (AF) and venous thromboembolism (VTE) and should be preferred over vi... |
PMC9931008 | core_pubmed_pmc | Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment | Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment Abstract Abstract Herbal interactions with nifedipine/felodipine through cytochrome P450 (CYP) 3A inhibition is significant in humans. Shengmai-San (SMS), a three-herbal formula of Chinese medicine, is ... |
PMC10044059 | core_pubmed_pmc | The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics | The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics Abstract Abstract Extracorporeal membrane oxygenation (ECMO) is becoming increasingly utilized to support critically ill patients who experience life-threatening cardiac or pulmonary compromise. The provision of this intervention poses ... |
PMC6014657 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose denosumab in healthy Chinese volunteers: A randomized, single-blind, placebo-controlled study | Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose denosumab in healthy Chinese volunteers: A randomized, single-blind, placebo-controlled study Abstract Abstract Background Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, a cytokine es... |
PMC11443207 | core_pubmed_pmc | FZ-AD005, a Novel DLL3-Targeted Antibody–Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models | FZ-AD005, a Novel DLL3-Targeted Antibody–Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models Abstract Abstract Delta-like ligand 3 (DLL3) is overexpressed in small cell lung cancer (SCLC) and has been considered an attractive target for SCLC therapy. Rovalpituzumab tesir... |
PMC6064581 | core_pubmed_pmc | Semaglutide s.c. Once-Weekly in Type 2 Diabetes: A Population Pharmacokinetic Analysis | Semaglutide s.c. Once-Weekly in Type 2 Diabetes: A Population Pharmacokinetic Analysis Abstract Abstract Introduction Semaglutide, a new treatment option approved for the treatment of patients with type 2 diabetes mellitus, is a glucagon-like peptide-1 receptor agonist to be injected subcutaneously once weekly. This an... |
PMC7067710 | core_pubmed_pmc | Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations | Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations Abstract Introduction A fixed-dose combination (FDC) of ibuprofen and acetaminophen has been developed that provides greater analgesic efficacy than either agent alone at the same doses wi... |
PMC7937944 | core_pubmed_pmc | Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers | Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers Abstract Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, ... |
PMC5465338 | core_pubmed_pmc | Pharmacokinetics of obinutuzumab in Chinese patients with B‐cell lymphomas | Pharmacokinetics of obinutuzumab in Chinese patients with B‐cell lymphomas Abstract Aim The Phase Ib GERSHWIN study ( NCT01680991 ) assessed the pharmacokinetic (PK) profile of obinutuzumab following multiple intravenous (i.v.) doses to Chinese patients with B‐cell lymphomas, and compared findings with previous obinutu... |
PMC9326885 | core_pubmed_pmc | Transporter-mediated interaction of indican and methotrexate in rats | Transporter-mediated interaction of indican and methotrexate in rats Abstract Abstract Indican (indoxyl-β-D-glucoside) is present in several Chinese herbs e.g. Isatis indigotica , Polygonum tinctorium and Polygonum perfoliatum . The major metabolite of indican was indoxyl sulfate (IS), an uremic toxin which was a known... |
PMC11326817 | core_pubmed_pmc | Oral Favipiravir Exposure and Pharmacodynamic Effects in Adult Outpatients With Acute Influenza | Oral Favipiravir Exposure and Pharmacodynamic Effects in Adult Outpatients With Acute Influenza Abstract Abstract Background The pharmacokinetics of oral favipiravir and the relationships of plasma concentrations to antiviral effects are incompletely studied in influenza. Methods Serial plasma samples were collected fr... |
PMC7066044 | core_pubmed_pmc | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy Abstract Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGF... |
PMC8099437 | core_pubmed_pmc | A novel method based on unbiased correlations tests for covariate selection in nonlinear mixed effects models: The COSSAC approach | A novel method based on unbiased correlations tests for covariate selection in nonlinear mixed effects models: The COSSAC approach Abstract Abstract Building a covariate model is a crucial task in population pharmacokinetics and pharmacodynamics in order to understand the determinants of the interindividual variability... |
PMC7603467 | core_pubmed_pmc | A workflow to build PBTK models for novel species | A workflow to build PBTK models for novel species Abstract Physiology-based pharmacokinetic and toxicokinetic (PBPK/TK) models allow us to simulate the concentration of xenobiotica in the plasma and different tissues of an organism. PBPK/TK models are therefore routinely used in many fields of life sciences to simulate... |
PMC10511598 | core_pubmed_pmc | Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations | Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations Abstract Abstract Dysphagia is increasingly common in older adults; it is especially prevalent in long-term care settings. Patients with dysphagia likely require pharmacologic treatment for multiple comorbiditie... |
PMC4772267 | core_pubmed_pmc | Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans | Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans Abstract Background: The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice. Methods: We characterized the pharmacokinetic pr... |
PMC11179699 | core_pubmed_pmc | Population pharmacokinetic‐pharmacodynamic modeling of serum biomarkers as predictors of tumor dynamics following lenvatinib treatment in patients with radioiodine‐refractory differentiated thyroid cancer (RR‐DTC) | Population pharmacokinetic‐pharmacodynamic modeling of serum biomarkers as predictors of tumor dynamics following lenvatinib treatment in patients with radioiodine‐refractory differentiated thyroid cancer (RR‐DTC) Abstract Abstract Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial ... |
PMC8504825 | core_pubmed_pmc | Design and conduct considerations for studies in patients with impaired renal function | Design and conduct considerations for studies in patients with impaired renal function Abstract Abstract An impaired renal function, including acute and chronic kidney disease and end‐stage renal disease, can be the result of aging, certain disease conditions, the use of some medications, or as a result of smoking. In ... |
PMC8365608 | core_pubmed_pmc | Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis | Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis Abstract Abstract Background: The advent of cystic fibrosis transmembrane conductance regulator protein (CFTR) modulators like ivacaftor have revolutionised the treatment of cystic fibrosis (CF). However, due to the plethora of var... |
PMC5461648 | core_pubmed_pmc | Characterizing QT interval prolongation in early clinical development: a case study with methadone | Characterizing QT interval prolongation in early clinical development: a case study with methadone Abstract Abstract Recently, we have shown how pharmacokinetic–pharmacodynamic ( PKPD ) modeling can be used to assess the probability of QT interval prolongation both in dogs and humans. A correlation between species has ... |
PMC12189457 | core_pubmed_pmc | Impact of Recovery from Febrile Neutropenia on Intra-Individual Variability in Vancomycin Pharmacokinetics in Pediatric Patients | Impact of Recovery from Febrile Neutropenia on Intra-Individual Variability in Vancomycin Pharmacokinetics in Pediatric Patients Abstract Background/Objectives: The pharmacokinetics of vancomycin (VCM) in patients with febrile neutropenia (FN) are highly variable due to coexisting conditions such as systemic inflammato... |
PMC8492921 | core_pubmed_pmc | Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report | Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report Abstract Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantopraz... |
PMC8597753 | core_pubmed_pmc | Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections | Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections Abstract ABSTRACT Tedizolid phosphate is an oxazolidinone antibacterial agent approved for the treatment of Gram-positive acute bacte... |
PMC11947576 | core_pubmed_pmc | Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers | Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers Abstract Abstract Background Benzodiazepines can exacerbate opioid-induced respiratory depression by furthering the decrease in central respiratory drive and causing loss of upper airway patency potentia... |
PMC12030116 | core_pubmed_pmc | Computational Investigation of Montelukast and Its Structural Derivatives for Binding Affinity to Dopaminergic and Serotonergic Receptors: Insights from a Comprehensive Molecular Simulation | Computational Investigation of Montelukast and Its Structural Derivatives for Binding Affinity to Dopaminergic and Serotonergic Receptors: Insights from a Comprehensive Molecular Simulation Abstract Background/Objectives : Montelukast (MLK), a leukotriene receptor antagonist, has been associated with neuropsychiatric s... |
PMC7348046 | core_pubmed_pmc | Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges | Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges Abstract With the advancement of technology, drug delivery systems and molecules with more complex architecture are developed. As a result, the drug absorption and disposition processes after administration of these dru... |
PMC12499688 | core_pubmed_pmc | Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study | Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study Abstract Background (6S)-5-Methyltetrahydrofolate ((6S)-5-MethylTHF) is the physiological folate form in biological fluids. Salts of (6S)-5-MethylTHF may have advantages compar... |
PMC11169681 | core_pubmed_pmc | Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway | Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway Abstract Naringenin (NAR) has various biological activities but low bioavailability. The current study examines the effect of Naringenin-loaded hybridized nanoparticles (NAR-HNPs) and NAR on depression induced ... |
PMC4696350 | core_pubmed_pmc | Cyclosporine A: Novel concepts in its role in drug-induced gingival overgrowth | Cyclosporine A: Novel concepts in its role in drug-induced gingival overgrowth Abstract Abstract Cyclosporine is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers t... |
PMC11502701 | core_pubmed_pmc | In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells | In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells Abstract This study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with... |
PMC5923181 | core_pubmed_pmc | Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria | Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria Abstract ABSTRACT Sulfadoxine-pyrimethamine with amodiaquine is recommended by the World Health Organization as seasonal malaria chemoprevention for children ... |
PMC11726676 | core_pubmed_pmc | Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention | Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention Abstract Abstract Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically va... |
PMC10508276 | core_pubmed_pmc | Systemic Ropivacaine Concentrations Following Local Infiltration Analgesia and Femoral Nerve Block in Older Patients Undergoing Total Knee Arthroplasty | Systemic Ropivacaine Concentrations Following Local Infiltration Analgesia and Femoral Nerve Block in Older Patients Undergoing Total Knee Arthroplasty Abstract Purpose The study examined the pharmacokinetic profile of fixed formulation mixtures comprising 225 mg of ropivacaine for local infiltration analgesia with or ... |
PMC11157233 | core_pubmed_pmc | A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms | A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms Abstract Abstract Background Quercetin, a widespread polyphenolic flavonoid, is known for its extensive health benefits and is commonly found in the plant kingdom. The natural occurrence and extraction methods of quercetin are c... |
PMC4118969 | core_pubmed_pmc | Nonlinear Mixed-Effects (NLME) Diameter Growth Models for Individual China-Fir ( Cunninghamia lanceolata ) Trees in Southeast China | Nonlinear Mixed-Effects (NLME) Diameter Growth Models for Individual China-Fir ( Cunninghamia lanceolata ) Trees in Southeast China Abstract An individual-tree diameter growth model was developed for Cunninghamia lanceolata in Fujian province, southeast China. Data were obtained from 72 plantation-grown China-fir trees... |
PMC6269737 | core_pubmed_pmc | Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes | Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes Abstract Abstract Honokiol is a bioactive component isolated from the medicinal herbs Magnolia officinalis and Magnolia grandiflora that has antioxidative, anti-inflammatory, antithrombotic, and antitumor a... |
PMC6581871 | core_pubmed_pmc | The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice | The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice Abstract Abstract Approximately 20 million adults in the United States have an alcohol use disorder. In recent years, modulation of the behavioral effects of ethanol by phytochemicals has been explored. In this study, ... |
PMC12797542 | core_pubmed_pmc | Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections | Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections Abstract Abstract Objective To validate a predictive risk score of early aggressive pharmacokinetic/pharmaco... |
PMC7611757 | core_pubmed_pmc | The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva | The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva Abstract In light of the recent global pandemic, Molnupiravir (MPV) or EIDD-2801, developed for the treatment of patients with uncomplicated ... |
PMC3774662 | core_pubmed_pmc | Age-Related P-Glycoprotein Expression in the Intestine and Affecting the Pharmacokinetics of Orally Administered Enrofloxacin in Broilers | Age-Related P-Glycoprotein Expression in the Intestine and Affecting the Pharmacokinetics of Orally Administered Enrofloxacin in Broilers Abstract Abstract Bioavailability is the most important factor for the efficacy of any drug and it is determined by P- glycoprotein (P-gp) expression. Confirmation of P-gp expression... |
PMC3500920 | core_pubmed_pmc | Repeat-dose steady-state pharmacokinetic evaluation of once-daily hydromorphone extended-release (OROS ® hydromorphone ER) in patients with chronic pain | Repeat-dose steady-state pharmacokinetic evaluation of once-daily hydromorphone extended-release (OROS ® hydromorphone ER) in patients with chronic pain Abstract Objective To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant med... |
PMC10020303 | core_pubmed_pmc | A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer | A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer Abstract Abstract Purpose In nonmetastatic hormone receptor-positive and Her2-negative breast cancer, preoperative endocrine therapies can yield outcomes similar with chem... |
PMC12241295 | core_pubmed_pmc | Evaluating the value of entomotoxicology in forensic toxicology casework using the first minipig model | Evaluating the value of entomotoxicology in forensic toxicology casework using the first minipig model Abstract Purpose A principal objective of forensic entomotoxicology is to apply insect specimens for post-mortem toxicological analysis. Successful identification of drugs in necrophagous insects may depend on pharmac... |
PMC7943506 | core_pubmed_pmc | Context-sensitive decrement times for inhaled anesthetics in obese patients explored with Gas Man® | Context-sensitive decrement times for inhaled anesthetics in obese patients explored with Gas Man® Abstract Anesthesia care providers and anesthesia decision support tools use mathematical pharmacokinetic models to control delivery and especially removal of anesthetics from the patient’s body. However, these models are... |
PMC11053887 | core_pubmed_pmc | Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics | Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics Abstract Pralsetinib is a kinase inhibitor indicated for the treatment of metastatic rearranged during transfection ( RET ) fusion-positive non-small cell lung cancer. Pralsetinib is primarily eliminated by the liver and hence hepatic impairment... |
PMC9354768 | core_pubmed_pmc | An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy | An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy Abstract ABSTRACT Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1... |
PMC5400328 | core_pubmed_pmc | Prevalence and risk factors for efavirenz-based antiretroviral treatment–associated severe vitamin D deficiency | Prevalence and risk factors for efavirenz-based antiretroviral treatment–associated severe vitamin D deficiency Abstract Abstract Initiation of efavirenz-based combination antiretroviral therapy (cART) is associated with Vitamin D deficiency, but the risk factors including efavirenz pharmacokinetics for cART-induced se... |
PMC9274904 | core_pubmed_pmc | Population Pharmacokinetics and Exposure‐Safety Relationships of Alisertib in Children and Adolescents With Advanced Malignancies | Population Pharmacokinetics and Exposure‐Safety Relationships of Alisertib in Children and Adolescents With Advanced Malignancies Abstract Abstract Population pharmacokinetic (PK) and exposure‐safety analyses of alisertib were performed in children enrolled in 2 clinical trials: NCT02444884 and NCT01154816 . NCT0244488... |
PMC7924150 | core_pubmed_pmc | A Case of SGLT2 Inhibitor-Associated Euglycemic Diabetic Ketoacidosis Following Coronary Artery Bypass Surgery | A Case of SGLT2 Inhibitor-Associated Euglycemic Diabetic Ketoacidosis Following Coronary Artery Bypass Surgery Abstract Abstract Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel group of oral hypoglycemic agents with multiple proven beneficial effects. However, their use has been associated with ... |
PMC5686859 | core_pubmed_pmc | Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism | Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism Abstract Abstract Interaction of procainamide hydrochloride (PAH) with human serum albumin (HSA) is of great significance in understanding the pharmacokinetic and pharmacod... |
PMC7214662 | core_pubmed_pmc | Making Better Dose Decisions: Using Exposure‐Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment | Making Better Dose Decisions: Using Exposure‐Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment Abstract Ubrogepant (MK‐1602) is a novel, oral, calcitonin gene‐related peptide receptor antagonist in clinical development with positive phase III outcomes ... |
PMC8944696 | core_pubmed_pmc | Antibiotics and ECMO in the Adult Population—Persistent Challenges and Practical Guides | Antibiotics and ECMO in the Adult Population—Persistent Challenges and Practical Guides Abstract Abstract Extracorporeal membrane oxygenation (ECMO) is an emerging treatment modality associated with a high frequency of antibiotic use. However, several covariables emerge during ECMO implementation, potentially jeopardiz... |
PMC6733303 | core_pubmed_pmc | Intracochlear PLGA based implants for dexamethasone release: Challenges and solutions | Intracochlear PLGA based implants for dexamethasone release: Challenges and solutions Abstract Abstract The effective treatment of diseases of the inner ear is currently an unmet medical need. Local controlled drug delivery to the cochlea is challenging due to the hidden location, small volume and high sensitivity of t... |
PMC9559938 | core_pubmed_pmc | Study and exploration of the pharmacokinetics of traditional Tibetan medicine Ruyi Zhenbao tablets after single and long-term administration | Study and exploration of the pharmacokinetics of traditional Tibetan medicine Ruyi Zhenbao tablets after single and long-term administration Abstract Tibetan medicine is one of the oldest traditional medicine systems in the world. Taking the Ruyi Zhenbao tablet (RYZB) as an example, which is a widely used classic oral ... |
PMC5424002 | core_pubmed_pmc | Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments | Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments Abstract Abstract Nicotinic acid (NiAc) is a potent inhibitor of adipose tissue lipolysis. Acute administration results in a rapid reduction of plasma free fatty acid (FFA) concentrations. Sustained NiAc expos... |
PMC9812811 | core_pubmed_pmc | A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 Diabetes | A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 Diabetes Abstract Abstract Metformin is the most often prescribed drug for people with type 2 diabetes (T2D). More than 120 million patients with T2D use metformin worldwide. However, monotherapy fails to achieve glycemic... |
PMC10590554 | core_pubmed_pmc | A Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS | A Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS Abstract Aim The goal of our study was to investigate the effects of single-dose simvastatin and itraconazole application on the pharmacokinetics of erlotinib in rats. Methods Twenty-... |
PMC3913652 | core_pubmed_pmc | Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action | Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action Abstract The design, synthesis and pharmacology of novel long-acting exenatide analogs for the treatment of metabolic diseases are described. These molecules display enhanced pharmacokinetic profi... |
PMC3489052 | core_pubmed_pmc | Bioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects | Bioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects Abstract Background The present study was conducted to compare the bioavailability of two bisoprolol fumarate 5 mg film-coated tablet formulations (test and reference formulations). Patients and methods This study wa... |
PMC5445997 | core_pubmed_pmc | A randomised, single-blind, single-dose, three-arm, parallel-group study in healthy subjects to demonstrate pharmacokinetic equivalence of ABP 501 and adalimumab | A randomised, single-blind, single-dose, three-arm, parallel-group study in healthy subjects to demonstrate pharmacokinetic equivalence of ABP 501 and adalimumab Abstract Objective To demonstrate pharmacokinetic (PK) similarity of biosimilar candidate ABP 501 relative to adalimumab reference product from the USA and Eu... |
PMC9887395 | core_pubmed_pmc | Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea | Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea Abstract Background Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and is active against most... |
PMC8720913 | core_pubmed_pmc | The concentration of brain homogenates with the Amicon Ultra Centrifugal filters | The concentration of brain homogenates with the Amicon Ultra Centrifugal filters Abstract Accurately measuring the brain concentration of a neurotherapeutic is critical in determining its pharmacokinetic profile in vivo . Biologics are potential therapeutics for neurologic diseases and biologics fused to an antibody ta... |
PMC8841463 | core_pubmed_pmc | Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator | Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator Abstract Abstract Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T... |
PMC6766527 | core_pubmed_pmc | Pharmacokinetics of mycophenolic acid and its effect on CD4 + and CD8 + T cells after oral administration of mycophenolate mofetil to healthy cats | Pharmacokinetics of mycophenolic acid and its effect on CD4 + and CD8 + T cells after oral administration of mycophenolate mofetil to healthy cats Abstract Abstract Background Mycophenolate mofetil (MMF) is an immunosuppressant used in human and veterinary medicine. Little pharmacokinetic and pharmacodynamic informatio... |
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