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PMC6121473 | core_pubmed_pmc | Investigation of Interactive Activity of Electro-Acupuncture on Pharmacokinetics of Sildenafil and Their Synergistic Effect on Penile Blood Flow in Rats | Investigation of Interactive Activity of Electro-Acupuncture on Pharmacokinetics of Sildenafil and Their Synergistic Effect on Penile Blood Flow in Rats Abstract Abstract Erectile dysfunction (ED) is a disorder found in males throughout the world, which negatively affects relationships with partners with advancing age.... |
PMC12888853 | core_pubmed_pmc | Pharmacokinetic-pharmacodynamic target attainment with continuous infusion piperacillin in patients admitted to the ICU with hospital-acquired pneumonia | Pharmacokinetic-pharmacodynamic target attainment with continuous infusion piperacillin in patients admitted to the ICU with hospital-acquired pneumonia Abstract ABSTRACT Optimizing β-lactam antibiotic exposure in critically ill patients with hospital-acquired pneumonia (HAP) remains a challenge due to significant phar... |
PMC9275846 | core_pubmed_pmc | Knowledge, Confidence, and Perception Toward Therapeutic Drug Monitoring Among Physicians and Pharmacists in Kuwait | Knowledge, Confidence, and Perception Toward Therapeutic Drug Monitoring Among Physicians and Pharmacists in Kuwait Abstract Supplemental Digital Content is Available in the Text. Key Words: therapeutic drug monitoring, clinical pharmacokinetics, perception, health care professionals, pharmacists Background: Therapeuti... |
PMC7455723 | core_pubmed_pmc | Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling | Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling Abstract Abstract Mosunetuzumab, a T-cell dependent bispecific antibody that binds CD3 and CD20 to drive T-cell mediated B-cell killing, is currently being te... |
PMC7269484 | core_pubmed_pmc | Nonclinical Pharmacokinetics, Protein Binding, and Elimination of KBP-7072, an Aminomethylcycline Antibiotic, in Animal Models | Nonclinical Pharmacokinetics, Protein Binding, and Elimination of KBP-7072, an Aminomethylcycline Antibiotic, in Animal Models Abstract KBP-7072 is a semisynthetic aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative pathogens, including multidrug-resistant bacterial strains. The phar... |
PMC9949646 | core_pubmed_pmc | p21 CIP/WAF1 saRNA inhibits proliferative vitreoretinopathy in a rabbit model | p21 CIP/WAF1 saRNA inhibits proliferative vitreoretinopathy in a rabbit model Abstract Abstract Purpose Proliferative vitreoretinopathy (PVR) is a disease process resulting from proliferation of retinal pigment epithelial (RPE) cells in the vitreous and periretinal area, leading to periretinal membrane formation and tr... |
PMC10003720 | core_pubmed_pmc | Pharmacokinetic Markers of Clinical Outcomes in Severe Mental Illness: A Systematic Review | Pharmacokinetic Markers of Clinical Outcomes in Severe Mental Illness: A Systematic Review Abstract The term severe mental illness (SMI) encompasses those psychiatric disorders exerting the highest clinical burden and socio-economic impact on the affected individuals and their communities. Pharmacogenomic (PGx) approac... |
PMC6587934 | core_pubmed_pmc | Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses | Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses Abstract Summary Background Misoprostol is an E prostanoid (EP) 2, 3 and 4 receptor agonist that is anecdotally used to treat and prevent NSAID‐induced GI injury in horses. Misoprostol elicits anti‐inflammatory effects in vivo in men a... |
PMC6698870 | core_pubmed_pmc | A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates | A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates Abstract Despite tremendous efforts in the field of targeted cancer therapy with antibody–drug conjugates (ADCs), attrition rates have been high. Historically, the priority in ADC developm... |
PMC10377753 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models | Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models Abstract Abstract Background Although polymyxin B has been in use since the late 1950s, there have been limited studies done to unravel its pharmacokinetics (PK) and pharmacodynamics (PD) ... |
PMC4740291 | core_pubmed_pmc | Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis | Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis Abstract Pericardial tuberculosis (TB) is associated with high therapy failure and high mortality rates. Antibiotics have to penetrate to site of infection at sufficient non-protein bound concentrations, and then enter bacteria to inhibit intr... |
PMC4599327 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects | Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects Abstract Abstract Introduction Nerve growth factor plays a key role in the pathology of osteoarthritis (OA) related chron... |
PMC11110484 | core_pubmed_pmc | Population pharmacokinetics and dose rationale for aciclovir in term and pre‐term neonates with herpes | Population pharmacokinetics and dose rationale for aciclovir in term and pre‐term neonates with herpes Abstract Abstract Aciclovir is considered the first‐line treatment against Herpes simplex virus (HSV) infections in new‐borns and infants. As renal excretion is the major route of elimination, in renally‐impaired pati... |
PMC10177510 | core_pubmed_pmc | A Multicenter, Open-Label, Phase I/II Study of FN-1501 in Patients with Advanced Solid Tumors | A Multicenter, Open-Label, Phase I/II Study of FN-1501 in Patients with Advanced Solid Tumors Abstract Abstract Simple Summary Fms-like tyrosine kinase type III (FLT3) inhibitors have been shown to induce significant clinical responses in patients with acute myeloid leukemia (AML) harboring FLT3 mutations. Responses to... |
PMC7889573 | core_pubmed_pmc | Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics | Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics Abstract Abstract Introduction Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the metabol... |
PMC8399305 | core_pubmed_pmc | The Influence of Omeprazole on the Dissolution Processes of pH-Dependent Magnetic Tablets Assessed by Pharmacomagnetography | The Influence of Omeprazole on the Dissolution Processes of pH-Dependent Magnetic Tablets Assessed by Pharmacomagnetography Abstract Abstract Pharmacomagnetography involves the simultaneous assessment of solid dosage forms (SDFs) in the human gastrointestinal (GI) tract and the drug plasmatic concentration, using a bio... |
PMC11280370 | core_pubmed_pmc | Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery | Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery Abstract Effective treatment of postoperative pain lasting for multiple days without opioids is an important clinical need. We previously reported analgesia lasting up to 96... |
PMC12970034 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial Abstract Abstract Purpose This study is the first-in-human study to evaluate the s... |
PMC5324643 | core_pubmed_pmc | Effect of Food on the Bioavailability of Omadacycline in Healthy Participants | Effect of Food on the Bioavailability of Omadacycline in Healthy Participants Abstract Abstract Omadacycline is a first‐in‐class aminomethylcycline antibiotic being evaluated in phase 3 studies as oral and intravenous monotherapy for bacterial infections. This was a phase 1, randomized, open‐label, 4‐period, crossover ... |
PMC6009247 | core_pubmed_pmc | General pharmacokinetic/pharmacodynamic concepts of mood stabilizers in the treatment of bipolar disorder | General pharmacokinetic/pharmacodynamic concepts of mood stabilizers in the treatment of bipolar disorder Abstract Abstract Introduction: Mood stabilizers are the recommended treatment for patients who receive a diagnosis of bipolar disorder. Because of the necessity of mood stabilizer treatment in patients with bipola... |
PMC9095526 | core_pubmed_pmc | Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review | Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review Abstract Background and Objective Clavulanic acid is a commonly used β-lactam inhibitor in pediatrics for a variety of infections. Clear insight into its mode of action is lacking, however, and a target has not been identifi... |
PMC5341069 | core_pubmed_pmc | Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto | Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto Abstract Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the mai... |
PMC6904902 | core_pubmed_pmc | An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats | An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats Abstract Abstract Background Injectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects. Objective This work aimed to develop an ... |
PMC9306723 | core_pubmed_pmc | A model‐based analysis to guide gonadotropin‐releasing hormone receptor antagonist use for management of endometriosis | A model‐based analysis to guide gonadotropin‐releasing hormone receptor antagonist use for management of endometriosis Abstract Aims To identify linzagolix doses, an oral GnRH receptor antagonist, that effectively lower oestradiol (E2) to relieve endometriosis‐related pelvic pain without compromising bone health. Metho... |
PMC5489386 | core_pubmed_pmc | Lipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS | Lipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS Methods Methods. Presented herein are PK results drawn at baseline and 1 year in the LA cohort of patients with secondary progressive MS enrolled in a randomized placebo-controlled trial of daily oral LA. The study was approved by the Veter... |
PMC10844526 | core_pubmed_pmc | Shizao decoction for cirrhotic ascites: assessing potential targets based on network analysis combined with pharmacokinetics and metabolomics | Shizao decoction for cirrhotic ascites: assessing potential targets based on network analysis combined with pharmacokinetics and metabolomics Abstract Introduction: Shizao decoction (SZD) is a traditional Chinese medicine decoction that has therapeutic effects on cirrhotic ascites (CAS). Because of the unclear treatmen... |
PMC12349936 | core_pubmed_pmc | Impact of Pharmacogenetics on Pharmacokinetics of First-Line Antituberculosis Drugs in the HIRIF Trial | Impact of Pharmacogenetics on Pharmacokinetics of First-Line Antituberculosis Drugs in the HIRIF Trial Abstract Abstract Background Variability in the pharmacokinetics (PK) of first-line antituberculosis drugs (rifampicin [RIF], isoniazid [INH], and pyrazinamide [PZA]) is high and may be influenced by pharmacogenetic p... |
PMC4596473 | core_pubmed_pmc | Randomized, Controlled, Thorough QT/QTc Study Shows Absence of QT Prolongation with Luseogliflozin in Healthy Japanese Subjects | Randomized, Controlled, Thorough QT/QTc Study Shows Absence of QT Prolongation with Luseogliflozin in Healthy Japanese Subjects Abstract Abstract Luseogliflozin is a selective sodium glucose co-transporter 2 (SGLT2) inhibitor. To evaluate the cardiac safety of luseogliflozin, a thorough QT/QTc study was conducted in he... |
PMC4207542 | core_pubmed_pmc | Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose | Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose Abstract Abstract Background The purpose of this study was to evaluate intestinal absorption, organ distribution, and urinary elimination of the rare sugar D-psicose, a 3-carbon stereoisomer of D-fructose that is currently bein... |
PMC9007601 | core_pubmed_pmc | Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups | Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups Abstract Abstract This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of dextromethorphan and its metabolites dextrorphan and dextrorphan O ‐g... |
PMC6595650 | core_pubmed_pmc | Efficacy and safety of simoctocog alfa (Nuwiq®) in patients with severe hemophilia A: a review of clinical trial data from the GENA program | Efficacy and safety of simoctocog alfa (Nuwiq®) in patients with severe hemophilia A: a review of clinical trial data from the GENA program Abstract Abstract Simoctocog alfa (human-cl rhFVIII, Nuwiq®) is a 4th generation recombinant FVIII (rFVIII), without chemical modification or fusion with any other protein/fragment... |
PMC9026229 | core_pubmed_pmc | High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics | High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics Abstract Abstract. Significance Dynamic diffuse fluorescence tomography (DFT) can recover the static distribution of fluorophores and track dynamic temporal events related to physiological and disease progression. Dynamic ... |
PMC6100585 | core_pubmed_pmc | Preparation, Characterization, Pharmacokinetics and Biodistribution of Baicalin-Loaded Liposome on Cerebral Ischemia-Reperfusion after i.v. Administration in Rats | Preparation, Characterization, Pharmacokinetics and Biodistribution of Baicalin-Loaded Liposome on Cerebral Ischemia-Reperfusion after i.v. Administration in Rats Abstract The dry root of Scutellaria baicalensis , has traditionally been applied in the treatment of cerebral ischemia in Chinese clinics. Baicalin (BA) is ... |
PMC10547006 | core_pubmed_pmc | Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions | Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions Abstract Abstract Objective This study compared the pharmacokinetic and safety profiles of generic and original vortioxetine hydrobromide tablets under fasting and fed conditions, and evaluated the bio... |
PMC9610297 | core_pubmed_pmc | An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations | An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations Abstract Abstract Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it p... |
PMC9761983 | core_pubmed_pmc | Pharmacogenetics of chemotherapy treatment response and -toxicities in patients with osteosarcoma: a systematic review | Pharmacogenetics of chemotherapy treatment response and -toxicities in patients with osteosarcoma: a systematic review Abstract Abstract Background Osteosarcoma is the most common bone tumor in children and adolescents. Despite multiagent chemotherapy, only 71% of patients survives and these survivors often experience ... |
PMC12394755 | core_pubmed_pmc | Optimizing Vancomycin Area under the Concentration-Time Curve Targets in Enterococcal Bacteremia: Balancing Efficacy and Nephrotoxicity | Optimizing Vancomycin Area under the Concentration-Time Curve Targets in Enterococcal Bacteremia: Balancing Efficacy and Nephrotoxicity Abstract Purpose Vancomycin is critical in treating enterococcal bacteremia; however, its optimal pharmacokinetic (PK)/pharmacodynamics (PD) targets remain unclear. This study evaluate... |
PMC2984118 | core_pubmed_pmc | Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits | Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits Abstract Abstract The aim of this study is to develop a sensitive HPLC method for the quantitative determination of cytisine in serum and to characterize the pharmacokinetic behaviour of cytisine after oral and intravenous administ... |
PMC5913959 | core_pubmed_pmc | Population Pharmacokinetics of High-Dose Tigecycline in Patients with Sepsis or Septic Shock | Population Pharmacokinetics of High-Dose Tigecycline in Patients with Sepsis or Septic Shock Abstract ABSTRACT Tigecycline is a glycylcycline often used in critically ill patients as the antibiotic of last resort. The pharmacokinetics (PK) of tigecycline in intensive care unit (ICU) patients can be affected by severe p... |
PMC10803641 | core_pubmed_pmc | Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study | Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study Abstract Abstract Objectives: Rituximab is frequently used off-label for the treatment of frequent-relapsing/steroid-... |
PMC11739178 | core_pubmed_pmc | No QT interval prolongation effect of sepiapterin: a concentration-QTc analysis of pooled data from phase 1 and phase 3 studies in healthy volunteers and patients with phenylketonuria | No QT interval prolongation effect of sepiapterin: a concentration-QTc analysis of pooled data from phase 1 and phase 3 studies in healthy volunteers and patients with phenylketonuria Abstract Abstract Sepiapterin is an exogenously synthesized new chemical entity that is structurally equivalent to endogenous sepiapteri... |
PMC5974000 | core_pubmed_pmc | Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling | Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling Abstract Abstract Background Fetal antiretroviral exposure is usually derived from the cord-to-maternal concentration ratio. This static parameter does not provide information on the... |
PMC5637898 | core_pubmed_pmc | Introduction of biosimilar insulins in Europe | Introduction of biosimilar insulins in Europe Abstract Abstract Regulatory approval of the first biosimilar insulin in Europe, LY 2963016 insulin glargine (Abasaglar ® ), in 2014 expanded the treatment options available to people with diabetes. As biosimilar insulin products come to market, it is important to recognize... |
PMC6086408 | core_pubmed_pmc | Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling | Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling Abstract Abstract Examining the dynamics of an agent in the tumor microenvironment can offer critical insights to the influx rate and accumulation of the agent. Intratumoral kinetic characterization in the in vivo setting can furth... |
PMC11656351 | core_pubmed_pmc | In Vitro and In Vivo Comparison of Random versus Site-Specific Conjugation of Bifunctional Chelating Agents to the CD33-Binding Antibody for Use in Alpha- and Beta-Radioimmunotherapy | In Vitro and In Vivo Comparison of Random versus Site-Specific Conjugation of Bifunctional Chelating Agents to the CD33-Binding Antibody for Use in Alpha- and Beta-Radioimmunotherapy Abstract Abstract Radiometal chelator conjugation is a cornerstone of radioimmunotherapy (RIT). Continued interest in selective placement... |
PMC7763912 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions | Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions Abstract The beta-blocker metoprolol (the sixth most commonly prescribed drug in the USA in 2017) is subject to considerable drug–gene interaction (DGI) effects caused by genetic va... |
PMC10107758 | core_pubmed_pmc | First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis | First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis Abstract Abstract Utreloxastat (PTC857) is a 15‐lipoxygenase inhibitor being developed to treat amyotrophic lateral sclerosis. This first‐in‐human study i... |
PMC8675330 | core_pubmed_pmc | Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation | Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation Abstract Abstract Depression is a common mental disorder. Its treatment with selective serotonin reuptake inhibitors (SSRIs) is effective only in a fraction of patients, and pharmacoresistance is increasing steadily. Intr... |
PMC7367921 | core_pubmed_pmc | Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation | Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation Abstract Abstract Background Bisphosphonates have very low bioavailability and cause irritation of the esophagus and stomach. This study was planned to improve the oral bioavaila... |
PMC6709472 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis | Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis Abstract The nitroimidazole DNDI-0690 is a clinical drug candidate for visceral leishmaniasis (VL) that also shows potent in vitro and in vivo activity against cutaneous leishmaniasis (CL). To support furthe... |
PMC11579191 | core_pubmed_pmc | Time Scale Calculus: a new approach to multi-dose pharmacokinetic modeling | Time Scale Calculus: a new approach to multi-dose pharmacokinetic modeling Abstract Abstract In this paper, we use Time Scale Calculus (TSC) to formulate and solve pharmacokinetic models exploring multiple dose dynamics. TSC is a mathematical framework that allows the modeling of dynamical systems comprising continuous... |
PMC4294077 | core_pubmed_pmc | Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response | Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response Abstract Abstract In oncology trials, overall survival (OS) is considered the most reliable and preferred endpoint to evaluate the benefit of drug treatment. Other relevant variables are also collected from patient... |
PMC7736906 | core_pubmed_pmc | Cabergoline as an adjuvant to standard heart failure treatment in peripartum cardiomyopathy: A case report and review of the literature | Cabergoline as an adjuvant to standard heart failure treatment in peripartum cardiomyopathy: A case report and review of the literature Abstract Abstract Introduction Peripartum cardiomyopathy (PPCM) is a rare and idiopathic form of dilated cardiomyopathy presenting late in pregnancy or early postpartum. Since the 16-k... |
PMC8146347 | core_pubmed_pmc | Role of Citicoline in the Management of Traumatic Brain Injury | Role of Citicoline in the Management of Traumatic Brain Injury Abstract Abstract Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improve... |
PMC8002057 | core_pubmed_pmc | Levothyroxine Interactions with Food and Dietary Supplements–A Systematic Review | Levothyroxine Interactions with Food and Dietary Supplements–A Systematic Review Abstract Abstract Levothyroxine ( l -thyroxine, l -T4) is a drug of choice for treating congenital and primary hypothyroidism. Although clinically significant interactions between l -T4 and food can alter the safety and efficacy of the tre... |
PMC3585840 | core_pubmed_pmc | Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-β-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects | Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-β-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects Abstract Background: Activation of the sympathetic nervous system is an important feature in hypertension and congestive heart failure. A strategy for directly m... |
PMC5790696 | core_pubmed_pmc | Separation and determination of acetyl-glutamine enantiomers by HPLC–MS and its application in pharmacokinetic study | Separation and determination of acetyl-glutamine enantiomers by HPLC–MS and its application in pharmacokinetic study Abstract A high-performance liquid chromatography coupled with mass spectrometry (HPLC–MS) method was established for the separation and determination of acetyl-glutamine enantiomers (acetyl- L -glutamin... |
PMC12460371 | core_pubmed_pmc | Deciphering structure-composition-efficacy transformation in processed Fuzi: an integrated SEM, XRD, metabolomics, and pharmacodynamics approach | Deciphering structure-composition-efficacy transformation in processed Fuzi: an integrated SEM, XRD, metabolomics, and pharmacodynamics approach Abstract Abstract Background Aconiti Lateralis Radix Praeparata (Fuzi), a vital yet toxic herbal medicine, faces significant challenges in standardization due to varied proces... |
PMC7984436 | core_pubmed_pmc | Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate | Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate Abstract Abstract This phase 1 study characterized the effect of multiple doses of upadacitinib, an oral Janus kinase 1 selective inhibitor, on the pharmacokinetics of the cytochrome P450... |
PMC5045027 | core_pubmed_pmc | Impact of pharmacist interventions in older patients: a prospective study in a tertiary hospital in Germany | Impact of pharmacist interventions in older patients: a prospective study in a tertiary hospital in Germany Abstract Abstract Background Inappropriate pharmacotherapy among older adults remains a critical issue in our health care systems. Besides polypharmacy and multiple comorbidities, the age-related pharmacokinetic ... |
PMC8753994 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Administered as an Adjunct to Bupivacaine for Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgery | Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Administered as an Adjunct to Bupivacaine for Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgery Abstract Abstract Background Despite the growing interest in dexmedetomidine as an adjunct to truncal blocks, little is known abo... |
PMC8451761 | core_pubmed_pmc | A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator | A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator Abstract Abstract Aims A mutation in the GBA1 gene is the most common genetic risk factor for developing Parkinson's disease. GBA1 encodes the lysosomal enzyme glucosylceramidase be... |
PMC8264131 | core_pubmed_pmc | In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model | In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model Abstract Abstract Background: Elimination of a drug during renal replacement therapy is not only dependent on flow rates, molecular size and protein binding, but is often influenc... |
PMC6272737 | core_pubmed_pmc | Simultaneous Determination of Five Components in Rat Plasma by UPLC–MS/MS and Its Application to a Comparative Pharmacokinetic Study in Baihe Zhimu Tang and Zhimu Extract | Simultaneous Determination of Five Components in Rat Plasma by UPLC–MS/MS and Its Application to a Comparative Pharmacokinetic Study in Baihe Zhimu Tang and Zhimu Extract Abstract Abstract Baihe Zhimu Tang (BZT) is a famous traditional Chinese medicine recipe to treat dry coughing due to yin deficiency and for moisturi... |
PMC6225219 | core_pubmed_pmc | Study on the Quality Evaluation of Compound Danshen Preparations Based on the xCELLigence Real-Time Cell-Based Assay and Pharmacodynamic Authentication | Study on the Quality Evaluation of Compound Danshen Preparations Based on the xCELLigence Real-Time Cell-Based Assay and Pharmacodynamic Authentication Abstract Objective : To perform a preliminary study on the quality evaluation of compound Danshen preparations based on the xCELLigence Real-Time Cell-based Assay (RTCA... |
PMC3425062 | core_pubmed_pmc | Two Formulations of Venlafaxine are Bioequivalent when Administered as Open Capsule Mixed with Applesauce to Healthy Subjects | Two Formulations of Venlafaxine are Bioequivalent when Administered as Open Capsule Mixed with Applesauce to Healthy Subjects Abstract Venlafaxine is a unique antidepressant approved for treatment of various depressive disorders. A single dose, cross-over bioequivalence study was performed with two different formulatio... |
PMC9103628 | core_pubmed_pmc | Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations | Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations Abstract Abstract Radiotherapy is one of the extensively used therapeutic modalities in glioblastoma and other types of cancers. Radiotherapy is either used as a fi... |
PMC12262704 | core_pubmed_pmc | Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus | Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus Abstract Lethal organophosphate (OP) exposure leads to status epilepticus (SE), which, despite standard-of-care therapy, is associated with ... |
PMC6791878 | core_pubmed_pmc | Evaluation of integrin αvβ 6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis | Evaluation of integrin αvβ 6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis Abstract Abstract Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knott... |
PMC8637440 | core_pubmed_pmc | Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids | Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids Abstract Abstract Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent modification of thiol... |
PMC6284592 | core_pubmed_pmc | Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia | Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia Abstract ABSTRACT Few treatment options are available for acute myeloid leukemia (AML) patients. DCLL9718A is an antibody-drug conjugate that targets C-type lectin-like molecule-1 (CLL-... |
PMC8161333 | core_pubmed_pmc | A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1 -Mutated Solid Tumors | A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1 -Mutated Solid Tumors Abstract Simple Summary Mutations in the isocitrate dehydrogenase 1 ( IDH1 ) gene occur in high-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma. Due to the lack of effective treatment options, ... |
PMC8453943 | core_pubmed_pmc | Single‐Dose Pharmacokinetics and Tolerability of the Oral Epidermal Growth Factor Receptor Inhibitor Mobocertinib (TAK‐788) in Healthy Volunteers: Low‐Fat Meal Effect and Relative Bioavailability of 2 Capsule Products | Single‐Dose Pharmacokinetics and Tolerability of the Oral Epidermal Growth Factor Receptor Inhibitor Mobocertinib (TAK‐788) in Healthy Volunteers: Low‐Fat Meal Effect and Relative Bioavailability of 2 Capsule Products Abstract Abstract Mobocertinib (TAK‐788) is a tyrosine kinase inhibitor under investigation for treatm... |
PMC12959156 | core_pubmed_pmc | Imipenem/cilastatin/relebactam dosing regimen justification using exposure–efficacy analyses in participants with hospital-acquired bacterial pneumonia or ventilator-associated bacterial pneumonia in the RESTORE-IMI 2 phase 3 study | Imipenem/cilastatin/relebactam dosing regimen justification using exposure–efficacy analyses in participants with hospital-acquired bacterial pneumonia or ventilator-associated bacterial pneumonia in the RESTORE-IMI 2 phase 3 study Abstract ABSTRACT An exposure–efficacy analysis of the phase 3 RESTORE-IMI 2 study ( NCT... |
PMC7901103 | core_pubmed_pmc | Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis | Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis Abstract Abstract Medications used for supportive care or prophylaxis constitute a significant portion of drug utilization in the intensive care unit. Evidence-based guidelines are available for many aspects ... |
PMC12567041 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling and Simulations in Lieu of Clinical Pharmacology Studies to Support the New Drug Application of Asciminib | Physiologically Based Pharmacokinetic Modeling and Simulations in Lieu of Clinical Pharmacology Studies to Support the New Drug Application of Asciminib Abstract Abstract Background : Asciminib (Scemblix ® ) is approved for the first-line treatment of adult patients with chronic myeloid leukemia in the chronic phase at... |
PMC8741448 | core_pubmed_pmc | Targeting immunoliposomes to EGFR-positive glioblastoma | Targeting immunoliposomes to EGFR-positive glioblastoma Abstract Background We assessed the capacity of epidermal growth factor receptor (EGFR)-targeted immunoliposomes to deliver cargo to brain tumor tissue in patients with relapsed glioblastoma harboring an EGFR amplification. We aimed to assess the tolerability and ... |
PMC8624226 | core_pubmed_pmc | Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study | Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study Abstract Levothyroxine (LT4) is a standard therapy in hypothyroidism; however, its bioavailability and therapeutic effects might... |
PMC5172848 | core_pubmed_pmc | First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics | First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics Abstract Abstract Objective: To evaluate the safety and pharmacokinetics of MIV-150 and zinc acetate in a carrageenan gel (PC-1005). Acceptability, adherence, and ... |
PMC4720490 | core_pubmed_pmc | Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015 | Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015 Abstract Drugs taken for cancer can interact with each other, with agents taken as part of supportive care, with drugs taken for comorbid cond... |
PMC11231114 | core_pubmed_pmc | Preclinical evaluation of [ 18 F]SYN1 and [ 18 F]SYN2, novel radiotracers for PET myocardial perfusion imaging | Preclinical evaluation of [ 18 F]SYN1 and [ 18 F]SYN2, novel radiotracers for PET myocardial perfusion imaging Abstract Background Positron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery disease, which is the main cause of death globally. The ... |
PMC5869557 | core_pubmed_pmc | Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects | Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects Abstract Abstract This study aimed to construct a physiologically based pharmacokinetic (PBPK) model of rifampicin that can accurately and quantitatively predict complex ... |
PMC5810840 | core_pubmed_pmc | Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients | Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients Abstract Background and purpose The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perio... |
PMC11394090 | core_pubmed_pmc | Laboratory Evaluation of Interferences Associated with Factor XIa Inhibitors Asundexian and Milvexian in Routine Coagulation Assays | Laboratory Evaluation of Interferences Associated with Factor XIa Inhibitors Asundexian and Milvexian in Routine Coagulation Assays Abstract Direct oral anticoagulants (DOACs) are increasingly used for the treatment of thrombosis. While inhibitors of factor IIa and factor Xa have shown effectiveness, the risk of bleedi... |
PMC8233537 | core_pubmed_pmc | Causes of vancomycin dosing error; problem detection and practical solutions; a retrospective, single-center, cross-sectional study | Causes of vancomycin dosing error; problem detection and practical solutions; a retrospective, single-center, cross-sectional study Abstract Vancomycindosing error and inappropriate monitoring is a common problem in hospital daily practice. In King Abdulaziz Medical City (KAMC) in Jeddah, a high percentage of abnormal ... |
PMC10301702 | core_pubmed_pmc | Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease | Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease Abstract Abstract INTRODUCTION Donanemab is an amyloid‐targeting therapy that specifically targets brain amyloid plaques. The objective of these analyses was to characterize the relationship of donanemab exposure with plasma biomarkers a... |
PMC7353904 | core_pubmed_pmc | Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review | Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review Abstract Background and objective : Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, whic... |
PMC3834946 | core_pubmed_pmc | Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure | Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure Abstract Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an oral drug would allow greater fl... |
PMC4223557 | core_pubmed_pmc | Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib | Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib Abstract Abstract Background Lenvatinib (E7080), an oral multi-kinase inhibitor, has inhibitory action on tumor cell proliferation and tumor angiogenesis in preclinical models. We evaluated cor... |
PMC8815855 | core_pubmed_pmc | Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease | Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease Abstract ABSTRACT The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective coh... |
PMC11889407 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of KT‐474, a Novel Selective Interleukin‐1 Receptor–Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults | Pharmacokinetics and Pharmacodynamics of KT‐474, a Novel Selective Interleukin‐1 Receptor–Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults Abstract ABSTRACT Interleukin‐1 receptor–associated kinase 4 (IRAK4), a key component of the Myddosome complex, mediates signaling through toll‐like and interleukin‐1 recepto... |
PMC8841439 | core_pubmed_pmc | Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial | Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial Abstract Abstract Tryptase is the most abundant secretory granule protein in human lung mast cells and plays an important role in asthma pathogenesis. MTPS9579A is a no... |
PMC9321387 | core_pubmed_pmc | Pharmacokinetics and Therapeutic Potential of Teucrium polium against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies | Pharmacokinetics and Therapeutic Potential of Teucrium polium against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies Abstract Abstract This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. ... |
PMC6852568 | core_pubmed_pmc | Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran | Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran Abstract Abstract Background Idarucizumab is a monoclonal antibody fragment that reverses dabigatran anticoagulation. Pharmacokinetics ( PK ) of idarucizumab have been described in ... |
PMC5803932 | core_pubmed_pmc | Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens | Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens Abstract Abstract Fosfomycin has emerged as a potential therapy for multidrug‐resistant bacterial infections. In most European countries, the oral formulation is only appro... |
PMC7076779 | core_pubmed_pmc | Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two-Compartment Hollow Fiber Infection Model | Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two-Compartment Hollow Fiber Infection Model Abstract Toxins produced by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) contribute to virulence. We developed a statistical approach to deter... |
PMC4790362 | core_pubmed_pmc | Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm | Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm Abstract The number of implanted medical devices is steadily increasing and has become an effective intervention improving life quality, but still carries the risk of infection. These infections are mainly cau... |
PMC11125362 | core_pubmed_pmc | Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication | Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication Abstract Abstract Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs. This study aimed to devel... |
PMC11678793 | core_pubmed_pmc | Pharmacodynamic Evaluation of Phage Therapy in Ameliorating ETEC-Induced Diarrhea in Mice Models | Pharmacodynamic Evaluation of Phage Therapy in Ameliorating ETEC-Induced Diarrhea in Mice Models Abstract Enterotoxigenic Escherichia coli (ETEC) is a major pathogen causing diarrhea in humans and animals, with increasing antimicrobial resistance posing a growing challenge in recent years. Lytic bacteriophages (phages)... |
PMC9885159 | core_pubmed_pmc | Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration | Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration Abstract Abstract Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. v... |
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