LiteFold/GO · Datasets at Hugging Face

GO:0070375

70,375

ERK5 cascade

biological_process

A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the d...

[ "PMID:16376520", "PMID:16880823", "PMID:20811974", "PMID:23125017", "PMID:28903453" ]

null

[ "big MAP kinase signaling cascade", "BMK cascade", "BMK signaling pathway", "BMK signalling pathway", "BMK1 cascade", "ERK5 signaling pathway", "extracellular signal-regulated kinase 5 cascade", "MAPK7 cascade" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000165" ]

[]

[ "GO:0000165" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26806\" xsd:anyURI" ]

null

false

true

3

GO:0070376

70,376

regulation of ERK5 cascade

biological_process

Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.

[ "GOC:add", "ISBN:0121245462", "ISBN:0896039986" ]

null

[ "regulation of BMK cascade", "regulation of BMK signaling pathway", "regulation of BMK signalling pathway", "regulation of BMK1 cascade", "regulation of ERK5 signaling pathway", "regulation of MAPK7 cascade" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043408" ]

[ "regulates GO:0070375" ]

[ "regulates" ]

[ "GO:0070375" ]

[ "GO:0043408", "GO:0070375" ]

[ "GO:0065007", "regulates GO:0070375" ]

[]

null

false

true

5

GO:0070377

70,377

negative regulation of ERK5 cascade

biological_process

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.

[ "GOC:add", "ISBN:0121245462", "ISBN:0896039986" ]

null

[ "down regulation of BMK cascade", "down-regulation of BMK cascade", "downregulation of BMK cascade", "inhibition of BMK cascade", "negative regulation of BMK cascade", "negative regulation of BMK signaling pathway", "negative regulation of BMK signalling pathway", "negative regulation of BMK1 cascade"...

[ "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043409", "GO:0070376" ]

[ "negatively_regulates GO:0070375" ]

[ "negatively_regulates" ]

[ "GO:0070375" ]

[ "GO:0043409", "GO:0070375", "GO:0070376" ]

[ "GO:0065007", "negatively_regulates GO:0070375" ]

[]

null

false

true

9

GO:0070378

70,378

positive regulation of ERK5 cascade

biological_process

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.

[ "GOC:mah" ]

null

[ "activation of BMK cascade", "positive regulation of BMK cascade", "positive regulation of BMK signaling pathway", "positive regulation of BMK signalling pathway", "positive regulation of BMK1 cascade", "positive regulation of ERK5 signaling pathway", "positive regulation of MAPK7 cascade", "stimulati...

[ "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043410", "GO:0070376" ]

[ "positively_regulates GO:0070375" ]

[ "positively_regulates" ]

[ "GO:0070375" ]

[ "GO:0043410", "GO:0070375", "GO:0070376" ]

[ "GO:0065007", "positively_regulates GO:0070375" ]

[]

null

false

true

7

GO:0070379

70,379

high mobility group box 1 binding

molecular_function

Binding to high mobility group box 1 (HMBGB1).

[ "GOC:add", "PMID:18431461" ]

null

[ "HMGB1 binding" ]

[ "EXACT" ]

[]

[ "GO:0019955" ]

[]

[ "GO:0019955" ]

[]

null

false

true

6

GO:0070381

70,381

endosome to plasma membrane transport vesicle

cellular_component

A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis.

[ "GOC:kad", "GOC:mah", "PMID:10679016", "PMID:12110576" ]

null

[ "endosome to plasma membrane constitutive secretory pathway transport vesicle", "endosome-plasma membrane transport vesicle" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070382" ]

[]

[ "GO:0070382" ]

[]

null

false

true

1

GO:0070382

70,382

exocytic vesicle

cellular_component

A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.

[ "GOC:kad", "GOC:mah" ]

null

[ "exocytic constitutive secretory pathway transport vesicle", "exocytotic vesicle" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0030133", "GO:0099503" ]

[]

[ "GO:0030133", "GO:0099503" ]

[]

null

false

true

4

GO:0070383

70,383

DNA cytosine deamination

biological_process

The removal of an amino group from a cytosine residue in DNA, forming a uracil residue.

[ "GOC:mah" ]

null

[]

[ "GO:0045006" ]

[]

[ "GO:0045006" ]

[]

null

false

true

7

GO:0070384

70,384

Harderian gland development

biological_process

The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the spec...

[ "GOC:hjd", "PMID:16856596", "PMID:7559104" ]

Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages.

[]

[ "GO:0048732" ]

[]

[ "GO:0048732" ]

[]

null

false

true

1

GO:0070385

70,385

egasyn-beta-glucuronidase complex

cellular_component

A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum.

[ "PMID:7744842" ]

null

[]

[ "GO:0140534" ]

[]

[ "GO:0140534" ]

[]

null

false

true

7

GO:0070387

70,387

procollagen-proline 4-dioxygenase complex, alpha(II) type

cellular_component

A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations.

[ "PMID:14500733", "PMID:7753822" ]

null

[ "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type", "prolyl 4-hydroxylase complex (alpha(II)-type)" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0016222" ]

[]

[ "GO:0016222" ]

[]

null

false

true

3

GO:0070388

70,388

procollagen-proline 4-dioxygenase complex, alpha(III) type

cellular_component

A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform.

[ "PMID:14500733" ]

null

[ "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type", "prolyl 4-hydroxylase complex (alpha(III)-type)" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0016222" ]

[]

[ "GO:0016222" ]

[]

null

false

true

3

GO:0070390

70,390

transcription export complex 2

cellular_component

A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p.

[ "GOC:dgf", "GOC:mah", "PMID:17786152", "PMID:19289793", "PMID:28334829" ]

null

[ "Sac3-Thp1-Sus1-Sem1-Cdc31 complex", "TREX-2 complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0140513" ]

[]

[ "GO:0140513" ]

[]

null

false

true

6

GO:0070392

70,392

detection of lipoteichoic acid

biological_process

The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.

[ "GOC:add", "PMID:14665680", "PMID:16020688" ]

null

[ "detection of LTA" ]

[ "EXACT" ]

[]

[ "GO:0032490", "GO:0070391" ]

[]

[ "GO:0032490", "GO:0070391" ]

[]

null

false

true

5

GO:0070393

70,393

teichoic acid catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues.

[ "GOC:add", "PMID:14665680" ]

null

[ "teichoic acid breakdown", "teichoic acid catabolism", "teichoic acid degradation" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0009057", "GO:0046374", "GO:1901136" ]

[]

[ "GO:0009057", "GO:0046374", "GO:1901136" ]

[]

null

false

true

1

GO:0070394

70,394

obsolete lipoteichoic acid metabolic process

biological_process

OBSOLETE. The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.

[ "GOC:add", "PMID:14665680", "PMID:16020688" ]

This term was obsoleted because it is an unnecessary grouping class.

[ "lipoteichoic acid metabolism", "LTA metabolic process" ]

[ "EXACT", "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30524\" xsd:anyURI" ]

null

true

9

GO:0070396

70,396

lipoteichoic acid catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.

[ "GOC:add", "PMID:14665680" ]

null

[ "lipoteichoic acid breakdown", "lipoteichoic acid catabolism", "lipoteichoic acid degradation" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0070393" ]

[]

[ "GO:0070393" ]

[]

null

false

true

6

GO:0070397

70,397

obsolete wall teichoic acid metabolic process

biological_process

OBSOLETE. The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to pe...

[ "GOC:add", "PMID:14665680", "PMID:16020688" ]

This term was obsoleted because it is an unnecessary grouping term.

[ "wall teichoic acid metabolism", "WTA metabolic process" ]

[ "EXACT", "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30524\" xsd:anyURI" ]

null

true

4

GO:0070398

70,398

wall teichoic acid biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently li...

[ "GOC:add", "PMID:14665680", "PMID:16020688" ]

null

[ "wall teichoic acid anabolism", "wall teichoic acid biosynthesis", "wall teichoic acid formation", "wall teichoic acid synthesis", "WTA biosynthetic process" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0019350" ]

[]

[ "GO:0019350" ]

[]

null

false

true

9

GO:0070399

70,399

wall teichoic acid catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently li...

[ "GOC:add", "PMID:14665680" ]

null

[ "wall teichoic acid breakdown", "wall teichoic acid catabolism", "wall teichoic acid degradation" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0016998", "GO:0070393" ]

[]

[ "GO:0016998", "GO:0070393" ]

[]

null

false

true

7

GO:0070400

70,400

teichoic acid D-alanylation

biological_process

The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid.

[ "GOC:add", "PMID:14665680", "PMID:16020688" ]

null

[ "teichoic acid alanylation" ]

[ "EXACT" ]

[]

[ "GO:0019350" ]

[]

[ "GO:0019350" ]

[]

null

false

true

8

GO:0070401

70,401

NADP+ binding

molecular_function

Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

[ "GOC:mah" ]

null

[ "NADP (oxidized) binding", "NADP binding", "oxidized NADP binding", "oxidized nicotinamide adenine dinucleotide phosphate binding" ]

[ "EXACT", "RELATED", "EXACT", "EXACT" ]

[]

[ "GO:0043168", "GO:0050661" ]

[]

[ "GO:0043168", "GO:0050661" ]

[]

null

false

true

5

GO:0070402

70,402

NADPH binding

molecular_function

Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

[ "GOC:mah" ]

null

[ "NADP (reduced) binding", "reduced NADP binding", "reduced nicotinamide adenine dinucleotide phosphate binding" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043168", "GO:0050661" ]

[]

[ "GO:0043168", "GO:0050661" ]

[]

null

false

true

3

GO:0070403

70,403

NAD+ binding

molecular_function

Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

[ "GOC:mah" ]

null

[ "NAD (oxidized) binding", "NAD binding", "oxidized NAD binding", "oxidized nicotinamide adenine dinucleotide binding" ]

[ "EXACT", "RELATED", "EXACT", "EXACT" ]

[]

[ "GO:0043168", "GO:0051287" ]

[]

[ "GO:0043168", "GO:0051287" ]

[]

null

false

true

6

GO:0070404

70,404

NADH binding

molecular_function

Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

[ "GOC:mah" ]

null

[ "NAD (reduced) binding", "reduced NAD binding", "reduced nicotinamide adenine dinucleotide binding" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043168", "GO:0051287" ]

[]

[ "GO:0043168", "GO:0051287" ]

[]

null

false

true

1

GO:0070405

70,405

ammonium ion binding

molecular_function

Binding to ammonium ions (NH4+).

[ "CHEBI:28938", "GOC:ecd" ]

null

[ "ammonium binding" ]

[ "RELATED" ]

[]

[ "GO:0043169" ]

[]

[ "GO:0043169" ]

[]

null

false

true

3

GO:0070406

70,406

L-glutamine binding

molecular_function

Binding to L-glutamine, 2,5-diamino-5-oxopentanoic acid.

[ "GOC:ecd" ]

null

[ "glutamine binding" ]

[ "BROAD" ]

[]

[ "GO:0016597", "GO:0031406", "GO:0043169" ]

[]

[ "GO:0016597", "GO:0031406", "GO:0043169" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27059\" xsd:anyURI" ]

null

false

true

3

GO:0070407

70,407

oxidation-dependent protein catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein.

[ "GOC:mah" ]

null

[ "oxidation-dependent protein breakdown", "oxidation-dependent protein catabolism", "oxidation-dependent protein degradation", "oxidation-dependent proteolysis", "oxidized protein catabolic process" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0019941" ]

[]

[ "GO:0019941" ]

[]

null

false

true

7

GO:0070408

70,408

carbamoyl phosphate metabolic process

biological_process

The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.

[ "CHEBI:17672", "GOC:mah", "GOC:rph" ]

null

[ "carbamoyl phosphate metabolism" ]

[ "EXACT" ]

[]

[ "UM-BBD_pathwayID:bzn" ]

[ "GO:0006796", "GO:0019637" ]

[]

[ "GO:0006796", "GO:0019637" ]

[]

null

false

true

1

GO:0070409

70,409

carbamoyl phosphate biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.

[ "CHEBI:17672", "GOC:mah", "GOC:rph" ]

null

[ "carbamoyl phosphate anabolism", "carbamoyl phosphate biosynthesis", "carbamoyl phosphate formation", "carbamoyl phosphate synthesis", "carbamyl phosphate biosynthetic process" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0070408", "GO:0090407" ]

[]

[ "GO:0070408", "GO:0090407" ]

[]

null

false

true

1

GO:0070410

70,410

co-SMAD binding

molecular_function

Binding to a common mediator SMAD signaling protein.

[ "GOC:BHF", "GOC:vk", "PMID:19114992" ]

null

[ "common mediator SMAD binding", "common partner SMAD binding", "common-mediator SMAD binding", "common-partner SMAD binding" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0046332" ]

[]

[ "GO:0046332" ]

[]

null

false

true

6

GO:0070411

70,411

I-SMAD binding

molecular_function

Binding to an inhibitory SMAD signaling protein.

[ "GOC:BHF", "GOC:vk", "PMID:19114992" ]

null

[]

[ "GO:0046332" ]

[]

[ "GO:0046332" ]

[]

null

false

true

3

GO:0070412

70,412

R-SMAD binding

molecular_function

Binding to a receptor-regulated SMAD signaling protein.

[ "GOC:BHF", "GOC:vk", "PMID:19114992" ]

null

[ "pathway restricted SMAD binding", "pathway-restricted SMAD binding", "receptor regulated SMAD binding", "receptor-regulated SMAD binding" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0046332" ]

[]

[ "GO:0046332" ]

[]

null

false

true

3

GO:0070413

70,413

obsolete trehalose metabolism in response to stress

biological_process

OBSOLETE. The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.

[ "GOC:jp", "GOC:mah", "PMID:9797333" ]

The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.

[ "trehalose metabolic process involved in response to stress" ]

[ "EXACT" ]

[]

[ "GO:0005991" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28943\" xsd:anyURI" ]

null

true

3

GO:0070414

70,414

obsolete trehalose metabolism in response to heat stress

biological_process

OBSOLETE. The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

[ "GOC:jp", "GOC:mah", "PMID:9797333" ]

The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.

[ "trehalose metabolic process involved in response to heat stress" ]

[ "EXACT" ]

[]

[ "GO:0005991" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28943\" xsd:anyURI" ]

null

true

7

GO:0070415

70,415

obsolete trehalose metabolism in response to cold stress

biological_process

OBSOLETE. The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.

[ "GOC:jp", "GOC:mah", "PMID:9797333" ]

The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.

[ "trehalose metabolic process involved in response to cold stress" ]

[ "EXACT" ]

[]

[ "GO:0005991" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28943\" xsd:anyURI" ]

null

true

9

GO:0070416

70,416

obsolete trehalose metabolism in response to water deprivation

biological_process

OBSOLETE. The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water.

[ "GOC:jp", "GOC:mah", "PMID:9797333" ]

The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.

[ "trehalose metabolic process involved in response to water deprivation" ]

[ "EXACT" ]

[]

[ "GO:0005991" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28943\" xsd:anyURI" ]

null

true

8

GO:0070419

70,419

nonhomologous end joining complex

cellular_component

A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.

[ "GOC:mah", "PMID:17072889", "PMID:17938628" ]

null

[ "NHEJ complex", "non-homologous end joining complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0140535", "GO:1990391" ]

[]

[ "GO:0140535", "GO:1990391" ]

[]

null

false

true

1

GO:0070421

70,421

DNA ligase III-XRCC1 complex

cellular_component

A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.

[ "PMID:15141024", "PMID:7760816" ]

null

[]

[ "GO:0140513", "GO:1902494" ]

[]

[ "GO:0140513", "GO:1902494" ]

[]

null

false

true

8

GO:0070422

70,422

G-protein beta/gamma-Raf-1 complex

cellular_component

A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.

[ "GOC:mah", "PMID:7782277" ]

See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.

[ "G protein complex (GNG2, GNB2L1, RAF1)" ]

[ "RELATED" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:0032991" ]

[]

null

false

true

6

GO:0070423

70,423

obsolete nucleotide-binding oligomerization domain containing signaling pathway

biological_process

OBSOLETE. The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing (NOD) protein receptor, and ending with regulation of a downstream cellular process.

[ "GOC:add", "PMID:17944960", "PMID:18585455" ]

This term was obsoleted because it is an unnecessary grouping term.

[ "NOD signaling pathway", "nucleotide-binding oligomerization domain containing signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0035872" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26556\" xsd:anyURI" ]

null

true

1

GO:0070424

70,424

regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

biological_process

Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.

[ "GOC:add" ]

null

[ "regulation of NOD signaling pathway", "regulation of nucleotide-binding oligomerization domain containing signaling pathway", "regulation of nucleotide-binding oligomerization domain containing signalling pathway" ]

[ "NARROW", "NARROW", "NARROW" ]

[]

[ "GO:0039531" ]

[ "regulates GO:0035872" ]

[ "regulates" ]

[ "GO:0035872" ]

[ "GO:0035872", "GO:0039531" ]

[ "GO:0065007", "regulates GO:0035872" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26556\" xsd:anyURI" ]

null

false

true

1

GO:0070425

70,425

negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

biological_process

Any process that stops, prevents, or reduces the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.

[ "GOC:add" ]

null

[ "negative regulation of NOD signaling pathway", "negative regulation of nucleotide-binding oligomerization domain containing signaling pathway", "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" ]

[ "NARROW", "NARROW", "NARROW" ]

[]

[ "GO:0039532", "GO:0070424" ]

[ "negatively_regulates GO:0035872" ]

[ "negatively_regulates" ]

[ "GO:0035872" ]

[ "GO:0035872", "GO:0039532", "GO:0070424" ]

[ "GO:0065007", "negatively_regulates GO:0035872" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26556\" xsd:anyURI" ]

null

false

true

8

GO:0070426

70,426

positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

biological_process

Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.

[ "GOC:add" ]

null

[ "positive regulation of NOD signaling pathway", "positive regulation of nucleotide-binding oligomerization domain containing signaling pathway", "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" ]

[ "NARROW", "NARROW", "NARROW" ]

[]

[ "GO:0062208", "GO:0070424", "GO:1902533" ]

[ "positively_regulates GO:0035872" ]

[ "positively_regulates" ]

[ "GO:0035872" ]

[ "GO:0035872", "GO:0062208", "GO:0070424", "GO:1902533" ]

[ "GO:0065007", "positively_regulates GO:0035872" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26556\" xsd:anyURI" ]

null

false

true

6

GO:0070427

70,427

nucleotide-binding oligomerization domain containing 1 signaling pathway

biological_process

The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process.

[ "GOC:add", "PMID:17944960", "PMID:18585455" ]

null

[ "NOD1 signaling pathway", "nucleotide-binding oligomerization domain containing 1 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0035872" ]

[]

[ "GO:0035872" ]

[]

null

false

true

1

GO:0070428

70,428

regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

biological_process

Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.

[ "GOC:add" ]

null

[ "regulation of NOD1 signaling pathway", "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070424" ]

[ "regulates GO:0070427" ]

[ "regulates" ]

[ "GO:0070427" ]

[ "GO:0070424", "GO:0070427" ]

[ "GO:0065007", "regulates GO:0070427" ]

[]

null

false

true

8

GO:0070429

70,429

negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

biological_process

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.

[ "GOC:add" ]

null

[ "negative regulation of NOD1 signaling pathway", "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070425", "GO:0070428" ]

[ "negatively_regulates GO:0070427" ]

[ "negatively_regulates" ]

[ "GO:0070427" ]

[ "GO:0070425", "GO:0070427", "GO:0070428" ]

[ "GO:0065007", "negatively_regulates GO:0070427" ]

[]

null

false

true

6

GO:0070430

70,430

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

biological_process

Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.

[ "GOC:add" ]

null

[ "positive regulation of NOD1 signaling pathway", "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070426", "GO:0070428" ]

[ "positively_regulates GO:0070427" ]

[ "positively_regulates" ]

[ "GO:0070427" ]

[ "GO:0070426", "GO:0070427", "GO:0070428" ]

[ "GO:0065007", "positively_regulates GO:0070427" ]

[]

null

false

true

5

GO:0070431

70,431

nucleotide-binding oligomerization domain containing 2 signaling pathway

biological_process

The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.

[ "GOC:add", "PMID:17944960", "PMID:18585455" ]

null

[ "NOD2 signaling pathway", "nucleotide-binding oligomerization domain containing 2 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0035872" ]

[]

[ "GO:0035872" ]

[]

null

false

true

6

GO:0070432

70,432

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

biological_process

Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.

[ "GOC:add" ]

null

[ "regulation of NOD2 signaling pathway", "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070424" ]

[ "regulates GO:0070431" ]

[ "regulates" ]

[ "GO:0070431" ]

[ "GO:0070424", "GO:0070431" ]

[ "GO:0065007", "regulates GO:0070431" ]

[]

null

false

true

5

GO:0070433

70,433

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

biological_process

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.

[ "GOC:add" ]

null

[ "negative regulation of NOD2 signaling pathway", "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070425", "GO:0070432" ]

[ "negatively_regulates GO:0070431" ]

[ "negatively_regulates" ]

[ "GO:0070431" ]

[ "GO:0070425", "GO:0070431", "GO:0070432" ]

[ "GO:0065007", "negatively_regulates GO:0070431" ]

[]

null

false

true

9

GO:0070434

70,434

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

biological_process

Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.

[ "GOC:add" ]

null

[ "positive regulation of NOD2 signaling pathway", "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070426", "GO:0070432" ]

[ "positively_regulates GO:0070431" ]

[ "positively_regulates" ]

[ "GO:0070431" ]

[ "GO:0070426", "GO:0070431", "GO:0070432" ]

[ "GO:0065007", "positively_regulates GO:0070431" ]

[]

null

false

true

6

GO:0070435

70,435

Shc-EGFR complex

cellular_component

A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.

[ "GOC:mah", "PMID:7798267" ]

null

[ "Shc-Egfr complex, EGF stimulated" ]

[ "NARROW" ]

[]

[ "GO:0098797" ]

[]

[ "GO:0098797" ]

[]

null

false

true

4

GO:0070436

70,436

Grb2-EGFR complex

cellular_component

A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.

[ "GOC:mah", "PMID:7798267" ]

null

[ "Grb2-Egfr complex, EGF stimulated" ]

[ "NARROW" ]

[]

[ "GO:0098797" ]

[]

[ "GO:0098797" ]

[]

null

false

true

7

GO:0070438

70,438

obsolete mTOR-FKBP12-rapamycin complex

cellular_component

OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus).

[ "GOC:sl", "PMID:20005306", "PMID:7822316" ]

This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally.

[ "Fkbp1a-Frap1 complex", "mTOR-FKBP12-rapamycin complex" ]

[ "NARROW", "EXACT" ]

[]

null

true

7

GO:0070439

70,439

Mad-Max-mSin3A complex

cellular_component

A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.

[ "PMID:7889570" ]

null

[]

[ "GO:0090571" ]

[]

[ "GO:0090571" ]

[]

null

false

true

6

GO:0070440

70,440

Mad-Max-mSin3B complex

cellular_component

A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.

[ "PMID:7889570" ]

null

[]

[ "GO:0090571" ]

[]

[ "GO:0090571" ]

[]

null

false

true

6

GO:0070441

70,441

G-protein beta/gamma-Btk complex

cellular_component

A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.

[ "GOC:mah", "PMID:7972043" ]

See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.

[ "G protein complex (BTK, GNG1, GNG2)", "G protein complex (Btk, Gng2, Gnb1)" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:0032991" ]

[]

null

false

true

6

GO:0070442

70,442

integrin alphaIIb-beta3 complex

cellular_component

An integrin complex that comprises one alphaIIb subunit and one beta3 subunit.

[ "PMID:12297042" ]

null

[ "alphaIIb-beta3 integrin complex", "ITGA2B-ITGB3 complex" ]

[ "EXACT", "NARROW" ]

[]

[ "GO:0008305" ]

[]

[ "GO:0008305" ]

[]

null

false

true

9

GO:0070443

70,443

Mad-Max complex

cellular_component

A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.

[ "PMID:8224841" ]

null

[]

[ "GO:0090571" ]

[]

[ "GO:0090571" ]

[]

null

false

true

1

GO:0070444

70,444

oligodendrocyte progenitor proliferation

biological_process

The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.

[ "GOC:mah", "GOC:sl", "PMID:15504915" ]

null

[ "oligodendrocyte precursor proliferation" ]

[ "EXACT" ]

[]

[ "GO:0061351" ]

[ "part_of GO:0042063" ]

[ "part_of" ]

[ "GO:0042063" ]

[ "GO:0042063", "GO:0061351" ]

[]

null

false

true

2

GO:0070445

70,445

regulation of oligodendrocyte progenitor proliferation

biological_process

Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.

[ "GOC:mah", "GOC:sl" ]

null

[ "regulation of oligodendrocyte precursor proliferation" ]

[ "EXACT" ]

[]

[ "GO:2000177" ]

[ "regulates GO:0070444" ]

[ "regulates" ]

[ "GO:0070444" ]

[ "GO:0070444", "GO:2000177" ]

[ "GO:0065007", "regulates GO:0070444" ]

[]

null

false

true

8

GO:0070446

70,446

negative regulation of oligodendrocyte progenitor proliferation

biological_process

Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation.

[ "GOC:mah", "GOC:sl" ]

null

[ "negative regulation of oligodendrocyte precursor proliferation" ]

[ "EXACT" ]

[]

[ "GO:0014014", "GO:0070445", "GO:2000178" ]

[ "negatively_regulates GO:0070444" ]

[ "negatively_regulates" ]

[ "GO:0070444" ]

[ "GO:0014014", "GO:0070444", "GO:0070445", "GO:2000178" ]

[ "GO:0065007", "negatively_regulates GO:0070444" ]

[]

null

false

true

3

GO:0070447

70,447

positive regulation of oligodendrocyte progenitor proliferation

biological_process

Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.

[ "GOC:mah", "GOC:sl" ]

null

[ "positive regulation of oligodendrocyte precursor proliferation" ]

[ "EXACT" ]

[]

[ "GO:0014015", "GO:0070445", "GO:2000179" ]

[ "positively_regulates GO:0070444" ]

[ "positively_regulates" ]

[ "GO:0070444" ]

[ "GO:0014015", "GO:0070444", "GO:0070445", "GO:2000179" ]

[ "GO:0065007", "positively_regulates GO:0070444" ]

[]

null

false

true

8

GO:0070448

70,448

laricitrin 5'-O-methyltransferase activity

molecular_function

Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin.

[ "RHEA:25633" ]

null

[ "CrCOMT2", "flavonoid 3',5'-O-dimethyltransferase activity", "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "KEGG_REACTION:R06816", "MetaCyc:RXN-8452", "RHEA:25633" ]

[ "GO:0008171", "GO:0008757" ]

[]

[ "GO:0008171", "GO:0008757" ]

[]

[ "skos:broadMatch EC:2.1.1.267", "skos:exactMatch RHEA:25633", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI" ]

null

false

true

8

GO:0070450

70,450

interleukin4-interleukin-4 receptor complex

cellular_component

A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule.

[ "GOC:mah", "PMID:10358772" ]

null

[ "IL4-IL4 receptor complex", "IL4-IL4R-IL2RG complex" ]

[ "EXACT", "NARROW" ]

[]

[ "GO:0098797" ]

[]

[ "GO:0098797" ]

[]

null

false

true

2

GO:0070451

70,451

cell hair

cellular_component

A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.

[ "PMID:11526084" ]

null

[ "imaginal disc-derived wing hair", "non-sensory hair" ]

[ "NARROW", "EXACT" ]

[]

[ "Wikipedia:Membrane_nanotube" ]

[ "GO:0120025" ]

[]

[ "GO:0120025" ]

[]

null

false

true

3

GO:0070452

70,452

positive regulation of ergosterol biosynthetic process

biological_process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.

[ "GOC:mah" ]

null

[ "activation of ergosterol biosynthetic process", "positive regulation of ergosterol anabolism", "positive regulation of ergosterol biosynthesis", "positive regulation of ergosterol formation", "positive regulation of ergosterol synthesis", "stimulation of ergosterol biosynthetic process", "up regulation...

[ "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0032443", "GO:0106120", "GO:1902932" ]

[ "positively_regulates GO:0006696" ]

[ "positively_regulates" ]

[ "GO:0006696" ]

[ "GO:0006696", "GO:0032443", "GO:0106120", "GO:1902932" ]

[ "GO:0065007", "positively_regulates GO:0006696" ]

[]

null

false

true

1

GO:0070453

70,453

regulation of heme biosynthetic process

biological_process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.

[ "GOC:mah" ]

null

[ "regulation of haem biosynthesis", "regulation of haem biosynthetic process", "regulation of heme anabolism", "regulation of heme biosynthesis", "regulation of heme formation", "regulation of heme synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:1901463" ]

[ "regulates GO:0006783" ]

[ "regulates" ]

[ "GO:0006783" ]

[ "GO:0006783", "GO:1901463" ]

[ "GO:0065007", "regulates GO:0006783" ]

[]

null

false

true

3

GO:0070454

70,454

negative regulation of heme biosynthetic process

biological_process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.

[ "GOC:mah" ]

null

[ "down regulation of heme biosynthetic process", "down-regulation of heme biosynthetic process", "downregulation of heme biosynthetic process", "inhibition of heme biosynthetic process", "negative regulation of haem biosynthetic process", "negative regulation of heme anabolism", "negative regulation of h...

[ "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0070453", "GO:1901464" ]

[ "negatively_regulates GO:0006783" ]

[ "negatively_regulates" ]

[ "GO:0006783" ]

[ "GO:0006783", "GO:0070453", "GO:1901464" ]

[ "GO:0065007", "negatively_regulates GO:0006783" ]

[]

null

false

true

6

GO:0070455

70,455

positive regulation of heme biosynthetic process

biological_process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.

[ "GOC:mah" ]

null

[ "activation of heme biosynthetic process", "positive regulation of haem biosynthetic process", "positive regulation of heme anabolism", "positive regulation of heme biosynthesis", "positive regulation of heme formation", "positive regulation of heme synthesis", "stimulation of heme biosynthetic process"...

[ "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0070453", "GO:1901465" ]

[ "positively_regulates GO:0006783" ]

[ "positively_regulates" ]

[ "GO:0006783" ]

[ "GO:0006783", "GO:0070453", "GO:1901465" ]

[ "GO:0065007", "positively_regulates GO:0006783" ]

[]

null

false

true

4

GO:0070456

70,456

galactose-1-phosphate phosphatase activity

molecular_function

Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate.

[ "GOC:mah" ]

null

[]

[ "GO:0050308" ]

[]

[ "GO:0050308" ]

[]

null

false

true

7

GO:0070457

70,457

D-galactose-1-phosphate phosphatase activity

molecular_function

Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate.

[ "GOC:mah", "PMID:9462881" ]

null

[]

[ "GO:0070456" ]

[]

[ "GO:0070456" ]

[]

null

false

true

3

GO:0070458

70,458

cellular detoxification of nitrogen compound

biological_process

Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.

[ "GOC:mah" ]

null

[ "cellular detoxification of nitrogenous compound" ]

[ "EXACT" ]

[]

[ "GO:0051410", "GO:1990748" ]

[ "part_of GO:0033554" ]

[ "part_of" ]

[ "GO:0033554" ]

[ "GO:0033554", "GO:0051410", "GO:1990748" ]

[]

null

false

true

6

GO:0070460

70,460

thyroid-stimulating hormone secretion

biological_process

The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.

[ "GOC:mah", "ISBN:0198506732" ]

null

[ "thyroid stimulating hormone secretion", "TSH secretion" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0030072" ]

[]

[ "GO:0030072" ]

[]

null

false

true

3

GO:0070461

70,461

SAGA-type complex

cellular_component

A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins...

[ "GOC:mah", "PMID:10637607", "PMID:17337012" ]

null

[ "SAGA family complex" ]

[ "EXACT" ]

[]

[ "GO:0000123" ]

[]

[ "GO:0000123" ]

[]

null

false

true

7

GO:0070462

70,462

plus-end specific microtubule depolymerization

biological_process

The removal of tubulin heterodimers from the plus end of a microtubule.

[ "GOC:krc", "PMID:16906145", "PMID:16906148" ]

null

[]

[ "GO:0007019" ]

[]

[ "GO:0007019" ]

[]

null

false

true

6

GO:0070463

70,463

tubulin-dependent ATPase activity

molecular_function

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.

[ "GOC:mah", "PMID:16906148" ]

null

[ "tubulin-activated ATPase activity" ]

[ "EXACT" ]

[]

[ "GO:0140657" ]

[]

[ "GO:0140657" ]

[]

null

false

true

8

GO:0070464

70,464

alphav-beta3 integrin-collagen alpha3(VI) complex

cellular_component

A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen.

[ "PMID:8387021" ]

null

[]

[ "GO:0098797" ]

[]

[ "GO:0098797" ]

[]

null

false

true

2

GO:0070466

70,466

alpha2-beta1 integrin-alpha3(VI) complex

cellular_component

A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.

[ "PMID:8387021" ]

null

[ "ITGA2-ITGB1-COL6A3 complex" ]

[ "NARROW" ]

[]

[ "GO:0098797" ]

[]

[ "GO:0098797" ]

[]

null

false

true

2

GO:0070467

70,467

RC-1 DNA recombination complex

cellular_component

A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA.

[ "PMID:8392064", "PMID:8670910" ]

null

[ "DNA recombination complex RC-1", "RC-1 complex (recombination complex 1)" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0140513" ]

[]

[ "GO:0140513" ]

[]

null

false

true

8

GO:0070468

70,468

dentin extracellular matrix secretion

biological_process

The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin.

[ "GOC:mah", "PMID:12856968" ]

null

[ "dentin secretion", "dentine secretion", "predentin secretion" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0070278" ]

[ "part_of GO:0042475" ]

[ "part_of" ]

[ "GO:0042475" ]

[ "GO:0042475", "GO:0070278" ]

[]

null

false

true

6

GO:0070469

70,469

obsolete respirasome

cellular_component

OBSOLETE. The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acc...

[ "GOC:ecd", "GOC:mah", "ISBN:0198547684", "Wikipedia:Respirasome" ]

The reason for obsoletion is that this term is equivalent to respiratory chain complex.

[ "membrane electron transport chain", "respiratory chain" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0098803" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12846\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27253\" xsd:anyURI" ]

null

true

7

GO:0070470

70,470

obsolete plasma membrane respirasome

cellular_component

OBSOLETE. A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associa...

[ "GOC:curators", "GOC:imk", "GOC:mah", "ISBN:0198547684" ]

The reason for obsoletion is that this term unnecssarily specified a cellular compartment.

[ "plasma membrane electron transport chain", "plasma membrane respiratory chain" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0098803" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12846\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27253\" xsd:anyURI" ]

null

true

5

GO:0070471

70,471

uterine smooth muscle contraction

biological_process

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ...

[ "GOC:sl" ]

null

[ "myometrial contraction", "myometrial smooth muscle contraction", "myometrium contraction" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0006939" ]

[]

[ "GO:0006939" ]

[]

null

false

true

8

GO:0070472

70,472

regulation of uterine smooth muscle contraction

biological_process

Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.

[ "GOC:curators" ]

null

[ "regulation of myometrial contraction", "regulation of myometrial smooth muscle contraction", "regulation of myometrium contraction" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0006940" ]

[ "regulates GO:0070471" ]

[ "regulates" ]

[ "GO:0070471" ]

[ "GO:0006940", "GO:0070471" ]

[ "GO:0065007", "regulates GO:0070471" ]

[]

null

false

true

4

GO:0070473

70,473

negative regulation of uterine smooth muscle contraction

biological_process

Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.

[ "GOC:curators" ]

null

[ "down regulation of uterine smooth muscle contraction", "down-regulation of uterine smooth muscle contraction", "downregulation of uterine smooth muscle contraction", "inhibition of uterine smooth muscle contraction", "negative regulation of myometrial contraction", "negative regulation of myometrial smoo...

[ "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "GO:0045986", "GO:0070472" ]

[ "negatively_regulates GO:0070471" ]

[ "negatively_regulates" ]

[ "GO:0070471" ]

[ "GO:0045986", "GO:0070471", "GO:0070472" ]

[ "GO:0065007", "negatively_regulates GO:0070471" ]

[]

null

false

true

5

GO:0070474

70,474

positive regulation of uterine smooth muscle contraction

biological_process

Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.

[ "GOC:curators" ]

null

[ "activation of uterine smooth muscle contraction", "positive regulation of myometrial contraction", "positive regulation of myometrial smooth muscle contraction", "positive regulation of myometrium contraction", "stimulation of uterine smooth muscle contraction", "up regulation of uterine smooth muscle co...

[ "NARROW", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0045987", "GO:0070472" ]

[ "positively_regulates GO:0070471" ]

[ "positively_regulates" ]

[ "GO:0070471" ]

[ "GO:0045987", "GO:0070471", "GO:0070472" ]

[ "GO:0065007", "positively_regulates GO:0070471" ]

[]

null

false

true

7

GO:0070475

70,475

rRNA base methylation

biological_process

The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.

[ "GOC:mah" ]

null

[]

[ "GO:0031167" ]

[]

[ "GO:0031167" ]

[]

null

false

true

2

GO:0070476

70,476

rRNA (guanine-N7)-methylation

biological_process

The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule.

[ "GOC:mah" ]

null

[]

[ "GO:0036265", "GO:0070475" ]

[]

[ "GO:0036265", "GO:0070475" ]

[]

null

false

true

1

GO:0070477

70,477

endospore core

cellular_component

An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive.

[ "GOC:mah", "PMID:15035041", "PMID:18035610" ]

null

[]

[ "GO:0005622" ]

[]

[ "GO:0005622" ]

[]

null

false

true

7

GO:0070478

70,478

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

biological_process

The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.

[ "PMID:12769863" ]

null

[ "3'-5' NMD", "3'-5' nonsense-mediated decay", "3'-5' nonsense-mediated mRNA decay", "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA degradation, 3'-5' exonucle...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000184" ]

[]

[ "GO:0000184" ]

[]

null

false

true

3

GO:0070479

70,479

nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay

biological_process

The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction.

[ "PMID:18554525" ]

The reason for obsoletion is that this term was an unnecessary grouping term.

[ "5'-3' NMD", "5'-3' nonsense-mediated decay", "5'-3' nonsense-mediated mRNA decay", "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA degradation, 5'-3' exonucle...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000184" ]

[]

[ "GO:0000184" ]

[]

null

false

true

3

GO:0070480

70,480

obsolete exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay

biological_process

OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay.

[ "GOC:jp" ]

The reason for obsoletion is that this term was an unnecessary grouping term.

[]

[ "GO:0031086" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26796\" xsd:anyURI" ]

null

true

4

GO:0070481

70,481

nuclear-transcribed mRNA catabolic process, non-stop decay

biological_process

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.

[ "PMID:11910110" ]

null

[ "non-stop decay", "non-stop mRNA decay", "nonstop mRNA decay", "nuclear-transcribed mRNA breakdown, non-stop decay", "nuclear-transcribed mRNA catabolism, non-stop decay", "nuclear-transcribed mRNA degradation, non-stop decay" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000956" ]

[]

[ "GO:0000956" ]

[]

null

false

true

9

GO:0070482

70,482

response to oxygen levels

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

[ "GOC:BHF", "GOC:mah" ]

null

[]

[ "GO:0009628" ]

[]

[ "GO:0009628" ]

[]

null

false

true

6

GO:0070483

70,483

detection of hypoxia

biological_process

The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

[ "GOC:BHF", "GOC:mah" ]

null

[ "detection of reduced oxygen levels" ]

[ "EXACT" ]

[]

[ "GO:0001666", "GO:0003032" ]

[]

[ "GO:0001666", "GO:0003032" ]

[]

null

false

true

4

GO:0070484

70,484

obsolete dehydro-D-arabinono-1,4-lactone metabolic process

biological_process

OBSOLETE. The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.

[ "GOC:cjk", "GOC:mah" ]

This term was obsoleted because it is an unnecessary grouping class.

[ "dehydro-D-arabinono-1,4-lactone metabolism" ]

[ "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30524\" xsd:anyURI" ]

null

true

6

GO:0070485

70,485

dehydro-D-arabinono-1,4-lactone biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.

[ "GOC:cjk", "GOC:mah" ]

null

[ "dehydro-D-arabinono-1,4-lactone anabolism", "dehydro-D-arabinono-1,4-lactone biosynthesis", "dehydro-D-arabinono-1,4-lactone formation", "dehydro-D-arabinono-1,4-lactone synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:1901336" ]

[]

[ "GO:1901336" ]

[]

null

false

true

5

GO:0070487

70,487

monocyte aggregation

biological_process

The adhesion of one monocyte to one or more other monocytes via adhesion molecules.

[ "GOC:sl", "PMID:12972508" ]

null

[ "mononuclear phagocyte aggregation" ]

[ "EXACT" ]

[]

[ "GO:0070486" ]

[]

[ "GO:0070486" ]

[]

null

false

true

9