LiteFold/InterPro · Datasets at Hugging Face

IPR016786

16,786

Uncharacterised protein YdeI, bacterial

YdeI_bac

Family

2,593

false

This entry specifically represents bacterial YdeI. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice [ ]. Production of the ydeI gene is regulated by the Rcs (regula...

[]

0

[ "PIRSF" ]

[ "PIRSF021308" ]

[ "UCP021308" ]

[ 2593 ]

1

[]

0

[]

0

[ "PUB00061992", "PUB00061993" ]

[ "17010160", "19767429" ]

[ "The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice.", "A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC." ]

[ 2006, 2009 ]

2

[]

0

null

[ "Bacteria", "Candidatus Nitrosomaritimum aestuariumsis", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 2571, 1, 1, 20 ]

4

[]

0

true

Family

Uncharacterised protein YdeI, bacterial

YdeI_bac

3

IPR016787

16,787

Uncharacterised conserved protein UCP021328

UCP021328

Family

1,744

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF11208", "PIRSF021328" ]

[ "DUF2992", "UCP021328" ]

[ 1744, 1497 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1735, 9 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP021328

UCP021328

8

IPR016789

16,789

Uncharacterised conserved protein UCP021389

UCP021389

Family

122

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF021389" ]

[ "UCP021389" ]

[ 122 ]

1

[]

0

[]

0

[]

0

[ "IPR019270" ]

[]

1

0

1

[ "Bacillales" ]

[ 122 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP021389

UCP021389

3

IPR016790

16,790

Thiol ester hydratase, Rv0216, predicted

Thiol_ester_hydratase_Rv0216

Family

1,803

false

This group represents a predicted thiol ester hydratase, Rv0216 type.

[]

0

[ "PIRSF" ]

[ "PIRSF021494" ]

[ "Rv0216_prd" ]

[ 1803 ]

1

[]

0

[ "2bi0", "4e3e", "8hgn" ]

3

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1786, 17 ]

2

[]

0

true

Family

Thiol ester hydratase, Rv0216, predicted

Thiol_ester_hydratase_Rv0216

9

IPR016791

16,791

Rubromycin-type polyketide biosynthesis protein, GrhN/RubW, predicted

Polyketide_synth_GrhN/RubW_prd

Family

315

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are found within operons involved in rubromycin-family polyketides [ ], and may be involved in their biosynthesis.

[]

0

[ "PIRSF" ]

[ "PIRSF021513" ]

[ "GrhN_RubW_prd" ]

[ 315 ]

1

[]

0

[]

0

[ "PUB00035941" ]

[ "12323376" ]

[ "A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A." ]

[ 2002 ]

1

[]

0

null

[ "Bacillati" ]

[ 315 ]

1

[]

0

true

Family

Rubromycin-type polyketide biosynthesis protein, GrhN/RubW, predicted

Polyketide_synth_GrhN/RubW_prd

4

IPR016792

16,792

Uncharacterised conserved protein UCP021573

UCP021573

Family

217

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF021573" ]

[ "UCP021573" ]

[ 217 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina" ]

[ 209, 8 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP021573

UCP021573

8

IPR016793

16,793

Uncharacterised conserved protein UCP021591

UCP021591

Family

603

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF021591" ]

[ "UCP021591" ]

[ 603 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycobacteriaceae" ]

[ 603 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP021591

UCP021591

6

IPR016795

16,795

Uncharacterised conserved protein UCP021697, membrane

UCP021697

Family

3,220

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PIRSF" ]

[ "PIRSF021697" ]

[ "UCP021697" ]

[ 3220 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 3201, 19 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP021697, membrane

UCP021697

1

IPR016796

16,796

Uncharacterised conserved protein UCP021774

UCP021774

Family

4,625

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae. The proteins members of this protein family adopt α/β fold consisting of a five-stranded β-sheet and α-helices packed on one side of the sheet [ ]. They form stable dimers involving the other side of their β-sheet . These proteins are s...

[]

0

[ "PIRSF" ]

[ "PIRSF021774" ]

[ "UCP021774" ]

[ 4625 ]

1

[]

0

[ "1j3m", "1q9u" ]

2

[ "PUB00028717" ]

[ "15481054" ]

[ "Crystal structure of a conserved hypothetical protein TT1751 from Thermus thermophilus HB8." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 565, 3946, 7, 107 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP021774

UCP021774

1

IPR016798

16,798

Uncharacterised conserved protein UCP021980, OB-fold

UCP021980_OB-fold

Family

3

false

This group represents a protein family with a predicted nucleic acid binding function.

[]

0

[ "PIRSF" ]

[ "PIRSF021980" ]

[ "UCP021980_RNA-bd" ]

[ 3 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanococcales" ]

[ 3 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP021980, OB-fold

UCP021980_OB-fold

6

IPR016799

16,799

Uncharacterised conserved protein UCP022062

UCP022062

Family

456

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF022062" ]

[ "UCP022062" ]

[ 456 ]

1

[]

0

[]

0

[]

0

[ "IPR013926" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 452, 4 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP022062

UCP022062

2

IPR016800

16,800

Uncharacterised conserved protein UCP022080

UCP022080

Family

149

false

This entry represents a family of archaeal proteins, including Ta0095 from Thermoplasma acidophilum ( ). This protein shows an α/β two-layer sandwich architecture formed by three α-helices and five β-strands. It is thought to bind a negatively charged molecule such as DNA, but its specific function remains unknown [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF022080" ]

[ "UCP022080" ]

[ 149 ]

1

[]

0

[ "2joi" ]

1

[ "PUB00047999" ]

[ "17766377" ]

[ "Solution structure of the hypothetical protein TA0095 from Thermoplasma acidophilum: a novel superfamily with a two-layer sandwich architecture." ]

[ 2007 ]

1

[]

0

null

[ "Methanobacteriati", "ecological metagenomes" ]

[ 145, 4 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP022080

UCP022080

2

IPR016801

16,801

Uncharacterised conserved protein UCP022207

UCP022207

Family

5

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF022207" ]

[ "UCP022207" ]

[ 5 ]

1

[]

0

[]

0

[]

0

[ "IPR009500" ]

[]

1

0

1

[ "Arabidopsis" ]

[ 5 ]

1

[ "Arabidopsis thaliana" ]

[ 3 ]

1

true

Family

Uncharacterised conserved protein UCP022207

UCP022207

4

IPR016802

16,802

Uncharacterised conserved protein UCP022260, magnoliopsida

UCP022260_magno

Family

23

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF022260" ]

[ "UCP022260" ]

[ 23 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mesangiospermae" ]

[ 23 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica" ]

[ 4, 3 ]

2

true

Family

Uncharacterised conserved protein UCP022260, magnoliopsida

UCP022260_magno

8

IPR016803

16,803

RGS1-HXK1-interacting protein 1

RHIP1

Family

28

false

RHIP1 provides a physical connection between the glucose signaling sensors RGS1 and HXK1, and is required for some glucose-regulated gene expression in plants [ ].

[ "GO:1902659" ]

[ "regulation of glucose mediated signaling pathway" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF022280" ]

[ "UCP022280" ]

[ 28 ]

1

[]

0

[]

0

[ "PUB00089257" ]

[ "26528314" ]

[ "Cooperative control between AtRGS1 and AtHXK1 in a WD40-repeat protein pathway in Arabidopsis thaliana." ]

[ 2015 ]

1

[ "IPR053284" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 28 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica" ]

[ 5, 2 ]

2

true

Family

RGS1-HXK1-interacting protein 1

RHIP1

9

IPR016804

16,804

Uncharacterised protein family UPF0114, plant

UPF0114_pln

Family

534

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF022348" ]

[ "UCP022348" ]

[ 534 ]

1

[]

0

[]

0

[]

0

[ "IPR005134" ]

[]

1

0

1

[ "Embryophyta" ]

[ 534 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 4, 4 ]

3

true

Family

Uncharacterised protein family UPF0114, plant

UPF0114_pln

9

IPR016805

16,805

Intermembrane space protein MIX23, fungal

MIX23_fungal

Family

799

false

The intermembrane space protein MIX23, also known as Caffeine-induced death protein 2 (Cid2), regulates or stabilises the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if th...

[ "GO:0005758" ]

[ "mitochondrial intermembrane space" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF022603" ]

[ "UCP022603" ]

[ 799 ]

1

[]

0

[]

0

[ "PUB00097118" ]

[ "32826315" ]

[ "The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor." ]

[ 2020 ]

1

[ "IPR019171" ]

[]

1

0

1

[ "Opisthokonta" ]

[ 799 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Intermembrane space protein MIX23, fungal

MIX23_fungal

6

IPR016806

16,806

COP9 signalosome complex, subunit 9, fungi

Csn9_fungi

Family

21

false

Csn9 is a component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes [ , ]. The CSN complex is involved in the regulation of the mating pheromone response [ ]....

[ "GO:0000338", "GO:0008180" ]

[ "protein deneddylation", "COP9 signalosome" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF022632" ]

[ "UCP022632" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00042896", "PUB00042897", "PUB00042898" ]

[ "12186635", "12672462", "12446563" ]

[ "Conservation of the COP9/signalosome in budding yeast.", "The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes.", "COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae." ]

[ 2002, 2003, 2002 ]

3

[]

0

null

[ "Saccharomycetaceae" ]

[ 21 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

COP9 signalosome complex, subunit 9, fungi

Csn9_fungi

9

IPR016807

16,807

Anaphase-promoting complex subunit Mnd2

Mnd2

Family

30

false

Mnd2 is part of the yeast anaphase-promoting complex (APC), a multisubunit E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis in eukaryotic cells [ ]. It is essential for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and sub...

[ "GO:0030071", "GO:0031145", "GO:0005680" ]

[ "regulation of mitotic metaphase/anaphase transition", "anaphase-promoting complex-dependent catabolic process", "anaphase-promoting complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF022699" ]

[ "MND2" ]

[ 30 ]

1

[]

0

[ "8a3t", "8a5y", "8a61" ]

3

[ "PUB00055007", "PUB00074596" ]

[ "12609981", "17459880" ]

[ "Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex.", "Mitotic phosphorylation of the anaphase-promoting complex inhibitory subunit Mnd2 is necessary for efficient progression through meiosis i." ]

[ 2003, 2007 ]

2

[]

0

null

[ "Saccharomycetaceae" ]

[ 30 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Anaphase-promoting complex subunit Mnd2

Mnd2

7

IPR016808

16,808

Mitochondrial morphogenesis protein Sld7

Sld7

Family

29

false

Sld7 interacts with Sld3 and is required for the proper function of Sld3 at the initiation of DNA replication [ ]. The origin association of Sld3, Sld7, and Cdc45 is the key to determining the temporal order of origin firing [ ]. Sld7 is also required for mitochondrial morphology [ ].

[ "GO:0030174" ]

[ "regulation of DNA-templated DNA replication initiation" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF022788" ]

[ "UCP022788" ]

[ 29 ]

1

[]

0

[]

0

[ "PUB00074950", "PUB00074951", "PUB00074952" ]

[ "21487389", "22169533", "16135527" ]

[ "Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast.", "Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing.", "Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae." ]

[ 2011, 2011, 2005 ]

3

[]

0

null

[ "Saccharomycotina" ]

[ 29 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial morphogenesis protein Sld7

Sld7

5

IPR016810

16,810

DNA repair protein Rad59

Rad59

Family

53

false

Rad59 is a paralogue of Rad52 and is involved in double-strand breaks (DSBs) DNA repair during vegetative growth via recombination and single-strand annealing [ ]. It is required for loading of Rad52 to DSBs [ ].

[ "GO:0045002" ]

[ "double-strand break repair via single-strand annealing" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF022936" ]

[ "RAD59_fungi" ]

[ 53 ]

1

[]

0

[]

0

[ "PUB00073604", "PUB00073605" ]

[ "23170228", "8769646" ]

[ "Rad59 regulates association of Rad52 with DNA double-strand breaks.", "A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae." ]

[ 2012, 1996 ]

2

[ "IPR007232" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 53 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

DNA repair protein Rad59

Rad59

4

IPR016811

16,811

Origin recognition complex, subunit 6, fungi

ORC6_fun

Family

144

false

This entry represents subunit 6, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1 and with trimethylated histone H3; phosphorylated by Cdc28 [ , ]. The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding comple...

[]

0

[ "PIRSF" ]

[ "PIRSF022941" ]

[ "ORC6_fun" ]

[ 144 ]

1

[]

0

[ "5v8f", "5zr1", "6rqc", "6wgc", "6wgg", "6wgi", "7mca", "7tjf", "7tjh", "7tji", "7tjj", "7tjk", "8zp5", "9bcx", "9gjp", "9gjw", "9gm5", "9i3i" ]

18

[ "PUB00011408", "PUB00052559", "PUB00052560", "PUB00052561", "PUB00052562", "PUB00052563", "PUB00052564", "PUB00052565", "PUB00052566", "PUB00052567", "PUB00052568", "PUB00052569", "PUB00052570", "PUB00052571", "PUB00052572", "PUB00052573", "PUB00052574", "PUB00052575", "PUB000525...

[ "11914271", "17241905", "17825065", "1579162", "7585959", "16716188", "7892251", "7781615", "16228006", "10966477", "12045100", "15680967", "11572976", "11429609", "16024805", "8622770", "9171055", "9038340", "11459976", "15610739", "16387651", "17053779", "9442876", "1...

[ "The origin recognition complex: from simple origins to complex functions.", "Multiple functions of the origin recognition complex.", "Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.", "ATP-dependent ...

[ 2002, 2007, 2007, 1992, 1995, 2006, 1995, 1995, 2005, 2000, 2002, 2005, 2001, 2001, 2005, 1996, 1997, 1997, 2001, 2004, 2006, 2006, 1997, 2003, 2004, 2007, 2019, 2020 ]

28

[]

0

null

[ "Dikarya" ]

[ 144 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Origin recognition complex, subunit 6, fungi

ORC6_fun

5

IPR016812

16,812

Protein phosphatase methylesterase, eukaryotic

PPase_methylesterase_euk

Family

4,940

false

This group represents eukaryotic protein phosphatase methylesterase 1. It demethylates proteins that have been reversibly carboxymethylated [ ]. Carboxymethylation is a highly conserved means of regulation in eukaryotic cells.

[ "GO:0051723", "GO:0006482" ]

[ "protein methylesterase activity", "protein demethylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF022950", "PTHR14189" ]

[ "PPase_methylesterase_euk", "" ]

[ 4010, 4940 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1.89", "R-BTA-69273", "R-CEL-69273", "R-DDI-69273", "R-HSA-69273", "R-MMU-69273", "R-RNO-69273", "R-SCE-69273", "R-SPO-69273" ]

[ "EC:3.1.1.89", "REACTOME:R-BTA-69273", "REACTOME:R-CEL-69273", "REACTOME:R-DDI-69273", "REACTOME:R-HSA-69273", "REACTOME:R-MMU-69273", "REACTOME:R-RNO-69273", "REACTOME:R-SCE-69273", "REACTOME:R-SPO-69273" ]

9

[ "3c5v", "3c5w", "7soy" ]

3

[ "PUB00068877" ]

[ "10318862" ]

[ "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 14, 4925, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 1, 2, 2, 1, 4, 4, 1, 1, 12 ]

12

true

Family

Protein phosphatase methylesterase, eukaryotic

PPase_methylesterase_euk

9

IPR016813

16,813

NADH-ubiquinone oxidoreductase 21.3 kDa subunit

NADH_Ub_cplx-1_21kDa

Family

1,604

false

This family represents a NADH-ubiquinone oxidoreductase 21.3 kDa subunit from Neurospora crassa [ ], NADH-ubiquinone oxidoreductase subunit NUO2 from Candida albicans [ , ] and similar fungal proteins.

[]

0

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF022976", "PTHR37325", "cd22849" ]

[ "NADH_Oxi_21kDa", "", "NuzM" ]

[ 1271, 1579, 1520 ]

3

[]

0

[ "6rfq", "6rfr", "6rfs", "6y79", "6yj4", "7b0n", "7o6y", "7o71", "7zm7", "7zmb", "7zmg", "9iho", "9ihp", "9ihq", "9ihr" ]

15

[ "PUB00084325", "PUB00148801", "PUB00153146" ]

[ "2137337", "25801605", "26087349" ]

[ "Primary structure, in vitro expression and import into mitochondria of a 29/21-kDa subunit of complex I from Neurospora crassa.", "Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis.", "Candida albicans cell shaving uncovers new p...

[ 1990, 2015, 2015 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1604 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

NADH-ubiquinone oxidoreductase 21.3 kDa subunit

NADH_Ub_cplx-1_21kDa

9

IPR016814

16,814

Profilin, apicomplexa

Profilin_apicomplexa

Family

109

false

Profilin is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). It can also in certain circumstance promote actin polymerisation. Profilin also binds to polyphosphoinositides such as PIP2. Overall sequence similarity amo...

[ "GO:0003779", "GO:0030036" ]

[ "actin binding", "actin cytoskeleton organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF022993" ]

[ "Profilin_apicomplexa" ]

[ 109 ]

1

[]

0

[ "2jkf", "2jkg", "3nec", "4d60" ]

4

[]

0

[ "IPR005455" ]

[]

1

0

1

[ "Apicomplexa" ]

[ 109 ]

1

[]

0

true

Family

Profilin, apicomplexa

Profilin_apicomplexa

3

IPR016815

16,815

Rhoptry 4/5

ROP4/5

Family

144

false

This entry represents rhoptry proteins ROP4 and ROP5 which are found in Toxoplasma gondii (phylum Apicomplexa), an obligate intracellular parasite for which the discharge of apical organelles named rhoptries is a key event in host cell invasion [ ]. These proteins contain a kinase-like domain ( ). ROP4 is localised to ...

[]

0

[ "PIRSF" ]

[ "PIRSF022995" ]

[ "Rhoptry_ROP2" ]

[ 144 ]

1

[]

0

[]

0

[ "PUB00042688", "PUB00042689", "PUB00042690", "PUB00042691", "PUB00052816", "PUB00065544", "PUB00160750", "PUB00160753", "PUB00160795", "PUB00160796", "PUB00160797", "PUB00160798", "PUB00160799" ]

[ "17022100", "15470260", "16879455", "17305424", "19197235", "21708941", "22802726", "26699401", "21436047", "21586633", "22761577", "23144612", "25118287" ]

[ "The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling.", "The Toxoplasma gondii rhoptry protein ROP4 is secreted into the parasitophorous vacuole and becomes phosphorylated in infected cells.", "Inverted topology of the Toxoplasma gondii ROP5 rhopt...

[ 2006, 2004, 2007, 2007, 2009, 2011, 2012, 2016, 2011, 2011, 2012, 2012, 2014 ]

13

[]

0

null

[ "Sarcocystidae" ]

[ 144 ]

1

[]

0

true

Family

Rhoptry 4/5

ROP4/5

2

IPR016816

16,816

Surface antigen p22

SAG2

Family

25

false

Toxoplasma gondii is an obligate intracellular apicomplexan protozoan parasite, with a complex lifestyle involving varied hosts. It has two phases of growth: an intestinal phase in feline hosts, and an extra-intestinal phase in other mammals. Oocysts from an infected cat develop into tachyzoites and, eventually, into b...

[]

0

[ "PIRSF" ]

[ "PIRSF022996" ]

[ "Surface_antigen_2" ]

[ 25 ]

1

[]

0

[]

0

[ "PUB00010595", "PUB00068149", "PUB00068150" ]

[ "10631570", "11052867", "23735002" ]

[ "Experimental approaches to understanding virulence in toxoplasmosis.", "Toxoplasma gondii: identification of a developmentally regulated family of genes related to SAG2.", "SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts." ]

[ 1999, 2000, 2013 ]

3

[]

0

null

[ "Toxoplasma gondii" ]

[ 25 ]

1

[]

0

true

Family

Surface antigen p22

SAG2

8

IPR016817

16,817

Mannose-P-dolichol utilization defect 1 protein

MannP-dilichol_defect-1

Family

6,085

false

This entry represents a group of eukaryotic transmembrane proteins, including mannose-P-dolichol utilization defect 1 protein [ ] and solute carrier family 66 member 3 (SLC66A3).

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF023381", "PTHR12226" ]

[ "MannP-dilichol_defect-1p", "" ]

[ 3801, 6085 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-446193", "R-DME-446193", "R-HSA-446193", "R-HSA-4687000", "R-MMU-446193" ]

[ "REACTOME:R-CEL-446193", "REACTOME:R-DME-446193", "REACTOME:R-HSA-446193", "REACTOME:R-HSA-4687000", "REACTOME:R-MMU-446193" ]

5

[]

0

[ "PUB00085119" ]

[ "11179430" ]

[ "Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6084, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 1, 5, 3, 24, 11, 1, 3, 8, 5 ]

10

true

Family

Mannose-P-dolichol utilization defect 1 protein

MannP-dilichol_defect-1

3

IPR016818

16,818

Nitric oxide synthase-interacting protein

NOSIP

Family

4,840

false

This entry includes animal NOSIP (nitric oxide synthase-interacting protein) and plant CSU1. They are ubiquitin E3 ligases [ , ]. Human NOSIP negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity [ , , ]. Arabidopsis CSU1 plays...

[ "GO:0061630" ]

[ "ubiquitin protein ligase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF023577", "PTHR13063" ]

[ "ENOS_interacting", "" ]

[ 2751, 4840 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-BTA-203754", "R-DDI-203754", "R-DME-203754", "R-HSA-203754", "R-MMU-203754" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-BTA-203754", "REACTOME:R-DDI-203754", "REACTOME:R-DME-203754", "REACTOME:R-HSA-203754", "REACTOME:R-MMU-203754" ]

7

[ "8c6j", "9fmd" ]

2

[ "PUB00073598", "PUB00073599", "PUB00073600", "PUB00086890", "PUB00086891" ]

[ "11149895", "15548660", "16135813", "25546391", "24838976" ]

[ "NOSIP, a novel modulator of endothelial nitric oxide synthase activity.", "Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.", "Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskelet...

[ 2001, 2004, 2005, 2014, 2014 ]

5

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4839, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 2, 2, 11, 7, 1, 4, 10, 16 ]

10

true

Family

Nitric oxide synthase-interacting protein

NOSIP

4

IPR016819

16,819

Ribonuclease P/MRP protein subunit Pop5

RNase_P/MRP_POP5

Family

2,359

false

Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [ ]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [ ]. Archaeal and eukaryote RNase P co...

[ "GO:0033204", "GO:0001682" ]

[ "ribonuclease P RNA binding", "tRNA 5'-leader removal" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF023803" ]

[ "Ribonuclease_P_prd" ]

[ 2359 ]

1

[ "REACTOME" ]

[ "R-HSA-6784531" ]

[ "REACTOME:R-HSA-6784531" ]

1

[ "6agb", "6ah3", "6ahr", "6ahu", "6w6v", "7c79", "7c7a" ]

7

[ "PUB00006321", "PUB00007201", "PUB00042727", "PUB00088366", "PUB00088367", "PUB00088368", "PUB00097414" ]

[ "7731988", "10024167", "15916546", "28971852", "21665995", "20627997", "21956908" ]

[ "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "Rpp14 and Rpp29, two protein subunits of human ribonuclease P.", "Probing the structure of Saccharomyces cerevisiae RNase MRP.", "Chance and necessity in the evolution of RNase P.", "Accumulation of noncoding RNA due to an RNase P de...

[ 1995, 1999, 2005, 2018, 2011, 2010, 2010 ]

7

[ "IPR002759" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "marine sediment metagenome" ]

[ 18, 2337, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 2, 2, 3, 3, 1, 1, 1, 4, 1, 1, 3 ]

11

true

Family

Ribonuclease P/MRP protein subunit Pop5

RNase_P/MRP_POP5

2

IPR016820

16,820

Mediator complex, subunit Med6, metazoa/plant

Mediator_Med6_met/pln

Family

1,655

false

null

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF023869" ]

[ "Mediator_MED6_meta/pln" ]

[ 1655 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

8

[ "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

14

[ "PUB00009761" ]

[ "9234719" ]

[ "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans." ]

[ 1997 ]

1

[ "IPR007018" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1655 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 1, 1, 1, 2, 4, 2, 2, 7, 1 ]

9

true

Family

Mediator complex, subunit Med6, metazoa/plant

Mediator_Med6_met/pln

7

IPR016821

16,821

G0/G1 switch protein 2

G0S2

Family

868

false

This group represents the G0/G1 switch protein 2 (G0S2) [ ]. In humans, it promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF15103", "PIRSF023925", "PTHR15570" ]

[ "G0-G1_switch_2", "G0/G1_switch_p2", "" ]

[ 868, 26, 854 ]

3

[ "REACTOME" ]

[ "R-HSA-1989781" ]

[ "REACTOME:R-HSA-1989781" ]

1

[]

0

[ "PUB00042869", "PUB00070028" ]

[ "1930693", "19706769" ]

[ "A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated.", "Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2." ]

[ 1991, 2009 ]

2

[]

0

null

[ "Canicola haemoglobinophilus", "Gnathostomata" ]

[ 1, 867 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1 ]

4

true

Family

G0/G1 switch protein 2

G0S2

6

IPR016823

16,823

Sulfur oxidation c-type cytochrome SoxX, type II

Thiosulf_SoxX_II

Family

449

false

Members of this family are SoxX, a c-type cytochrome with a CxxCH motif, part of a heterodimer with SoxA. SoxAX cytochromes play a key role in bacterial thiosulfate oxidation [ , ]. There are three distinct types of SoxAX proteins. Type I and II SoxAX proteins are heterodimers, while the heterotrimeric SoxAXK proteins ...

[]

0

[ "PIRSF" ]

[ "PIRSF024608" ]

[ "UCP024608" ]

[ 449 ]

1

[]

0

[ "3oa8", "3ocd" ]

2

[ "PUB00021732", "PUB00074852", "PUB00074853" ]

[ "12411478", "22907414", "21592966" ]

[ "Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.", "The bacterial SoxAX cytochromes.", "Insights into structure and function of the active site of SoxAX cytochromes." ]

[ 2002, 2013, 2011 ]

3

[ "IPR030999" ]

[]

1

0

1

[ "Bacteria", "mine drainage metagenome" ]

[ 447, 2 ]

2

[]

0

true

Family

Sulfur oxidation c-type cytochrome SoxX, type II

Thiosulf_SoxX_II

4

IPR016824

16,824

Tfp pilus assembly protein FimT

Tfp-pilus_assembly_FimT

Family

306

false

This group represents a Tfp pilus assembly protein FimT.

[]

0

[ "PIRSF" ]

[ "PIRSF024622" ]

[ "Tfp_FimT" ]

[ 306 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 306 ]

1

[]

0

true

Family

Tfp pilus assembly protein FimT

Tfp-pilus_assembly_FimT

1

IPR016825

16,825

Flagella-related protein F

Flagellin-rel_FlaF

Family

9

false

This group represents a predicted flagella-related protein F, found primarily, though not exclusively, in Pyrococcus spp.

[]

0

[ "PIRSF" ]

[ "PIRSF024658" ]

[ "FlaF_archaea_prd" ]

[ 9 ]

1

[]

0

[]

0

[]

0

[ "IPR002774" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 9 ]

1

[]

0

true

Family

Flagella-related protein F

Flagellin-rel_FlaF

5

IPR016827

16,827

Transcriptional adaptor 2

Ada2/TADA2

Family

5,086

false

This entry represents a group of transcriptional adaptors, including transcriptional adapter 2 (TADA2) from animals and plants, and Ada2 from yeasts. Ada2 is a component of the SAGA/ADA coactivator complex, which regulates numerous cellular processes by coordinating histone acetylation [ , ]. There are two Drosophila A...

[ "GO:0003713", "GO:0006357" ]

[ "transcription coactivator activity", "regulation of transcription by RNA polymerase II" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF025024" ]

[ "Transcriptional_adaptor_2" ]

[ 5086 ]

1

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2053", "GenProp2055", "R-BTA-9772755", "R-DME-5689880", "R-DRE-5689880", "R-HSA-3214847", "R-HSA-5689880", "R-HSA-9772755", "R-MMU-9772755", "R-RNO-9772755", "R-SCE-5689880", "R-SPO-5689880" ]

[ "GP:GenProp2053", "GP:GenProp2055", "REACTOME:R-BTA-9772755", "REACTOME:R-DME-5689880", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-9772755", "REACTOME:R-RNO-9772755", "REACTOME:R-SCE-5689880", "REACTOME:R-SPO-5689880"...

12

[]

0

[ "PUB00053704", "PUB00073506", "PUB00073507", "PUB00073508" ]

[ "19103755", "11777910", "19279142", "12697829" ]

[ "The double-histone-acetyltransferase complex ATAC is essential for mammalian development.", "The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.", "Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida ...

[ 2009, 2002, 2009, 2003 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5086 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 11, 3, 3, 5, 2, 1, 4, 6, 1, 1, 15 ]

11

true

Family

Transcriptional adaptor 2

Ada2/TADA2

7

IPR016829

16,829

Spodoptera frugiperda nuclear polyhedrosis virus (SfNPV), sf27

SfNPV_sf27

Family

76

false

This entry is represented by Spodoptera frugiperda nuclear polyhedrosis virus (SfNPV), sf27; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27725", "PIRSF025479" ]

[ "SfNPV_sf27", "UCP025479" ]

[ 76, 45 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Alphabaculovirus" ]

[ 76 ]

1

[]

0

true

Family

Spodoptera frugiperda nuclear polyhedrosis virus (SfNPV), sf27

SfNPV_sf27

1

IPR016830

16,830

Ubiquinone biosynthesis accessory factor UbiT

UbiT

Family

2,785

false

This family represents the UbiT (also known as YhbT) protein. It is involved in the ubiquinone biosynthesis pathway alongside UbiU (YhbU), and UbiV (YhbV). UbiT contains an SCP2 domain which binds the hydrophobic UQ biosynthetic intermediates and structures a multiprotein Ubi complex [ ].

[ "GO:0006744" ]

[ "ubiquinone biosynthetic process" ]

[ "biological_process" ]

1

[ "HAMAP", "PIRSF" ]

[ "MF_02231", "PIRSF025550" ]

[ "UbiT", "UCP025550_lpd_carrier" ]

[ 2783, 1811 ]

2

[]

0

[]

0

[ "PUB00093388" ]

[ "30686758" ]

[ "A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2769, 16 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ubiquinone biosynthesis accessory factor UbiT

UbiT

7

IPR016831

16,831

PPi-dependent kinase

PPi-dep_kinase

Family

77

false

This family includes proteins predominantly found in Bacteroidetes, such as from Thermotoga maritima. This enzyme, member of the ribokinase family, uses inorganic pyrophosphate (PPi) but neither ATP nor ADP to generate myo-inositol monophosphate. It contains two large hydrophobic residues partially obstructing the ATP-...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF025725", "cd01937" ]

[ "UCP025725", "ribokinase_group_D" ]

[ 55, 76 ]

2

[]

0

[ "1vk4", "5ysp", "5ysq", "7e4l" ]

4

[ "PUB00086033", "PUB00100671" ]

[ "23441918", "29720581" ]

[ "Novel inositol catabolic pathway in Thermotoga maritima.", "Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants." ]

[ 2013, 2018 ]

2

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 14, 61, 2 ]

3

[]

0

true

Family

PPi-dependent kinase

PPi-dep_kinase

8

IPR016833

16,833

Putative sodium bile acid cotransporter

Put_Na-Bile_cotransptr

Family

13,570

false

This family includes sodium/bile acid cotransporter 7 [ ] and other uncharacterised proteins with sodium bile acid cotransporter domain; they are found both in prokaryotes and eukaryotes.They are related to the human bile acid:sodium symporters, which are transmembrane proteins functioning in the liver in the uptake of...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF13593", "PIRSF026166", "PTHR18640" ]

[ "SBF_like", "UCP026166", "" ]

[ 13479, 9743, 12979 ]

3

[]

0

[]

0

[ "PUB00004723", "PUB00057362" ]

[ "1961729", "15932064" ]

[ "Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.", "Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family." ]

[ 1991, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 20, 9016, 4488, 46 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 8, 1, 1, 4, 2, 1, 8, 2, 26 ]

9

true

Family

Putative sodium bile acid cotransporter

Put_Na-Bile_cotransptr

1

IPR016835

16,835

Uncharacterised conserved protein UCP026317, WGR

UCP026317_WGR

Family

8

false

This group represents an uncharacterised protein with WGR domain.

[]

0

[ "PIRSF" ]

[ "PIRSF026317" ]

[ "UCP026317_WGR" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 8 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP026317, WGR

UCP026317_WGR

2

IPR016836

16,836

Long-chain acyl-[acyl-carrier-protein] reductase

AAR

Family

374

false

This entry represents Long-chain acyl-[acyl-carrier-protein] reductase from Synechococcus elongatus (ARR) and similar proteins from Cyanobacteria. ARR reduces a long-chain (mainly C16 or C18) fatty acyl ACP ester to its corresponding fatty aldehyde, releasing the acyl carrier protein (ACP) [ ]. NADPH is the reductant f...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF026396", "TIGR04058" ]

[ "UCP026396_short-chain_DH", "AcACP_reductase" ]

[ 367, 374 ]

2

[ "GP" ]

[ "GenProp0942" ]

[ "GP:GenProp0942" ]

1

[ "6jzq", "6jzu", "6jzy", "6jzz" ]

4

[ "PUB00055010", "PUB00100129" ]

[ "20671186", "32251275" ]

[ "Microbial biosynthesis of alkanes.", "Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase." ]

[ 2010, 2020 ]

2

[]

0

null

[ "Cyanobacteriota" ]

[ 374 ]

1

[]

0

true

Family

Long-chain acyl-[acyl-carrier-protein] reductase

AAR

3

IPR016837

16,837

Uncharacterised protein family Ycf55, cyanobacteria

Uncharacterised_Ycf55_cyanobac

Family

302

false

This entry represents proteins annotated as Ycf55. It is found encoded in the chloroplast genomes of algae, it is also found in plants and in the cyanobacteria. The function is unknown, though there are two completely conserved residues (L and D) that may be functionally important. As the family is exclusively found in...

[]

0

[ "PIRSF" ]

[ "PIRSF026434" ]

[ "RR_ycf55_prd" ]

[ 302 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 302 ]

1

[]

0

true

Family

Uncharacterised protein family Ycf55, cyanobacteria

Uncharacterised_Ycf55_cyanobac

7

IPR016838

16,838

Uncharacterised conserved protein UCP026449

UCP026449

Family

237

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF026449" ]

[ "UCP026449" ]

[ 237 ]

1

[]

0

[]

0

[]

0

[ "IPR019283" ]

[]

1

0

1

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 236, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP026449

UCP026449

2

IPR016839

16,839

Signal transduction diguanylate cyclase, CHASE2 sensor domain-containing, predicted

Sig_transdc_diG_cyclase_prd

Family

14

false

This entry represents predicted signal transduction diguanylate cyclases (diG cyclase) that have a CHASE2 sensor domain [ ]. DiG cyclase catalyses the synthesis of two molecules of cyclic dinucleotide bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) from two molecules of GTP. The cyclic nucleotide c-di-GMP...

[]

0

[ "PIRSF" ]

[ "PIRSF026492" ]

[ "ST_diguanylate_cyclase_prd" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00042801", "PUB00042802" ]

[ "17236651", "17697992" ]

[ "Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases.", "Diguanylate cyclase activation: it takes two." ]

[ 2006, 2007 ]

2

[]

0

null

[ "Bacteria" ]

[ 14 ]

1

[]

0

true

Family

Signal transduction diguanylate cyclase, CHASE2 sensor domain-containing, predicted

Sig_transdc_diG_cyclase_prd

8

IPR016840

16,840

Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase

Glyco_hydro_43_endo_a_Ara-ase

Family

4,483

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0046558" ]

[ "arabinan endo-1,5-alpha-L-arabinosidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF026534" ]

[ "Endo_alpha-L-arabinosidase" ]

[ 4483 ]

1

[ "EC" ]

[ "3.2.1.99" ]

[ "EC:3.2.1.99" ]

1

[ "1gyd", "1gye", "1gyh", "1uv4", "1wl7", "3cu9", "3d5y", "3d5z", "3d60", "3d61", "6a8h", "6a8i", "6b7k", "6f1g" ]

14

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[ "IPR006710" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2377, 2099, 7 ]

3

[]

0

true

Family

Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase

Glyco_hydro_43_endo_a_Ara-ase

2

IPR016841

16,841

Transcription regulator DksA-related, predicted

Tscrpt_reg_DksA-rel_prd

Family

188

false

This group represents a predicted transcriptional regulator DksA-related protein.

[]

0

[ "PIRSF" ]

[ "PIRSF026544" ]

[ "DksA_homologue_prd" ]

[ 188 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus" ]

[ 188 ]

1

[]

0

true

Family

Transcription regulator DksA-related, predicted

Tscrpt_reg_DksA-rel_prd

3

IPR016842

16,842

Protein of unknown function UCP026546, HtH-CBS

UCP026546_HTH-CBS

Family

2,316

false

This group represents an uncharacterised protein with a N-termial HtH domain and a C-terminal CBS domain pair. Proteins in this entry include transcriptional repressor CcpN from Bacillus subtilis. CcpN is a transcription repressor that binds to the promoter of gapB and pckA genes, preventing their expression. It acts a...

[]

0

[ "PIRSF" ]

[ "PIRSF026546" ]

[ "UCP026546_CBS_YqzB" ]

[ 2316 ]

1

[]

0

[]

0

[ "PUB00070772" ]

[ "15720552" ]

[ "CcpN (YqzB), a novel regulator for CcpA-independent catabolite repression of Bacillus subtilis gluconeogenic genes." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2305, 11 ]

2

[]

0

true

Family

Protein of unknown function UCP026546, HtH-CBS

UCP026546_HTH-CBS

5

IPR016843

16,843

S-adenosyl-L-methionine dependent adenine methyltransferase, bacteria, predicted

S-AdoMet-dep_Ade-MeTrfase_prd

Family

2,172

false

This group represents a predicted S-adenosyl-L-methionine dependent adenine methyltransferase, bacterial type.

[]

0

[ "PIRSF" ]

[ "PIRSF026567" ]

[ "Adenine_mtase_bact_prd" ]

[ 2172 ]

1

[]

0

[ "2f8l" ]

1

[]

0

[]

0

null

[ "Bacilli", "human gut metagenome" ]

[ 2171, 1 ]

2

[]

0

true

Family

S-adenosyl-L-methionine dependent adenine methyltransferase, bacteria, predicted

S-AdoMet-dep_Ade-MeTrfase_prd

7

IPR016844

16,844

Uncharacterised conserved protein UCP026610

UCP026610

Family

49

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF026610" ]

[ "UCP026610" ]

[ 49 ]

1

[]

0

[]

0

[]

0

[ "IPR060687" ]

[]

1

0

1

[ "Mycobacteriales" ]

[ 49 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP026610

UCP026610

3

IPR016845

16,845

Uncharacterised conserved protein UCP026633, TfuA-like, mycobacteria

UCP026633_TfuA-like

Family

51

false

This group represents an uncharacterised protein with TfuA-like domain, Mycobacterium type.

[]

0

[ "PIRSF" ]

[ "PIRSF026633" ]

[ "UCP026633_TfuA-like" ]

[ 51 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycobacterium" ]

[ 51 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP026633, TfuA-like, mycobacteria

UCP026633_TfuA-like

5

IPR016846

16,846

Predicted ion channel, cNMP-binding

cNMP-bd_ion_channel

Family

1,515

false

This entry represents a group of predicted ion channels with a cNMP-binding (cyclic nucleotide-binding) domain ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF026673" ]

[ "UCP026673_ion_chan" ]

[ 1515 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1515 ]

1

[]

0

true

Family

Predicted ion channel, cNMP-binding

cNMP-bd_ion_channel

1

IPR016847

16,847

Mannose-6-phosphate isomerase, Firmicutes, long form, predicted

Man6P_Isoase_Firm_lng_prd

Family

489

false

This group represents a predicted mannose-6-phosphate isomerase, Firmicutes type, long form. PMI_Firm_long_prd

[]

0

[ "PIRSF" ]

[ "PIRSF026713" ]

[ "PMI_Firm_long_prd" ]

[ 489 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 489 ]

1

[]

0

true

Family

Mannose-6-phosphate isomerase, Firmicutes, long form, predicted

Man6P_Isoase_Firm_lng_prd

4

IPR016848

16,848

Ribonuclease P/MRP subunit Rpp29

RNase_P/MRP_Rpp29-subunit

Family

4,600

false

Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [ ]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [ ]. Archaeal and eukaryote RNase P co...

[ "GO:0033204", "GO:0001682", "GO:0006396", "GO:0000172", "GO:0030677" ]

[ "ribonuclease P RNA binding", "tRNA 5'-leader removal", "RNA processing", "ribonuclease MRP complex", "ribonuclease P complex" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PIRSF", "PANTHER" ]

[ "PIRSF027081", "PTHR13348" ]

[ "RNase_P/MRP_p29_subunit", "" ]

[ 2192, 4600 ]

2

[ "REACTOME" ]

[ "R-HSA-6784531" ]

[ "REACTOME:R-HSA-6784531" ]

1

[ "1ts9", "1tsf", "2ki7", "6agb", "6ah3", "6ahr", "6ahu", "6k0a", "6k0b", "6w6v", "7c79", "7c7a" ]

12

[ "PUB00006321", "PUB00007201", "PUB00031561", "PUB00042726", "PUB00042727", "PUB00088366", "PUB00088367", "PUB00088368", "PUB00097414" ]

[ "7731988", "10024167", "15518563", "10352175", "15916546", "28971852", "21665995", "20627997", "21956908" ]

[ "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "Rpp14 and Rpp29, two protein subunits of human ribonuclease P.", "Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus.", "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleopro...

[ 1995, 1999, 2004, 1999, 2005, 2018, 2011, 2010, 2010 ]

9

[ "IPR002730" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "bioreactor metagenome" ]

[ 97, 4502, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 3, 5, 1, 1, 4, 2, 1, 1, 13 ]

12

true

Family

Ribonuclease P/MRP subunit Rpp29

RNase_P/MRP_Rpp29-subunit

6

IPR016849

16,849

Histone acetyltransferase Rtt109

Rtt109

Family

1,704

false

Rtt109, also known as KAT11, is fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome stability and resistance to a variety of DNA-damaging agents. Rtt109 does not show sequence conservation with other known HATs and depends on association with either of two histon...

[ "GO:0010484", "GO:0006325", "GO:0005634" ]

[ "histone H3 acetyltransferase activity", "chromatin organization", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PROFILE" ]

[ "PIRSF027124", "PS51728" ]

[ "Histone_acetylase_Rtt109", "RTT109_HAT" ]

[ 41, 1704 ]

2

[ "EC" ]

[ "2.3.1.48" ]

[ "EC:2.3.1.48" ]

1

[ "2rim", "2zfn", "3cz7", "3q33", "3q35", "3q66", "3q68", "3qm0", "5zb9", "5zba", "5zbb", "6o22", "7bwz", "7bx0", "7bx1", "7bxw", "7c3o", "8gq3", "8gq4" ]

19

[ "PUB00049390", "PUB00051187", "PUB00051225", "PUB00099563", "PUB00099564" ]

[ "18707894", "18719104", "18568037", "31194870", "29300933" ]

[ "Structural insights into histone H3 lysine 56 acetylation by Rtt109.", "Molecular basis for the autoregulation of the protein acetyl transferase Rtt109.", "Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.", "Two factor authentication: Asf1 mediates crosstalk b...

[ 2008, 2008, 2008, 2019, 2018 ]

5

[ "IPR013178" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1704 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Histone acetyltransferase Rtt109

Rtt109

4

IPR016850

16,850

Transcription initiation factor Rrn11, budding yeast

TIF_Rrn11_budding_yeast

Family

17

false

The RNA polymerase I specific transcription initiation factor Rrn11 is a member of a multiprotein complex essential for the initiation of transcription by RNA polymerase I, together with Rrn6 and Rrn7 subunits [ , ]. Binding to the DNA template is dependent on the initial binding of other factors [ ]. Rrn11 contains a ...

[]

0

[ "PIRSF" ]

[ "PIRSF027133" ]

[ "Rrn11" ]

[ 17 ]

1

[]

0

[ "5n5y", "5n5z", "5n60", "5n61", "5o7x", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6rqh", "6rql", "6rrd", "6rui", "6ruo", "6rwe", "6tps" ]

17

[ "PUB00020262", "PUB00099775", "PUB00100002" ]

[ "12095692", "28340337", "28623663" ]

[ "Characterization of a fission yeast subunit of an RNA polymerase I essential transcription initiation factor, SpRrn7h/TAF(I)68, that bridges yeast and mammals: association with SpRrn11h and the core ribosomal RNA gene promoter.", "Structural Basis of RNA Polymerase I Transcription Initiation.", "Structural mec...

[ 2002, 2017, 2017 ]

3

[ "IPR053029" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 17 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Transcription initiation factor Rrn11, budding yeast

TIF_Rrn11_budding_yeast

2

IPR016851

16,851

Kinetochore-associated protein Nnf1

Nnf1

Family

106

false

Nnf1 is an essential component of the MIND kinetochore complex required for accurate chromosome segregation [ ].

[ "GO:0000444" ]

[ "MIS12/MIND type complex" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF027153" ]

[ "Nnf1p" ]

[ 106 ]

1

[]

0

[ "5t58", "5wwl" ]

2

[ "PUB00017334" ]

[ "12455957" ]

[ "Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae." ]

[ 2002 ]

1

[ "IPR007128" ]

[]

1

0

1

[ "Dikarya" ]

[ 106 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2 ]

2

true

Family

Kinetochore-associated protein Nnf1

Nnf1

8

IPR016852

16,852

SET domain methyltransferase

SET_MeTrfase

Family

1,002

false

The ribosomal protein L12ab (Rpl12ab) in Saccharomyces cerevisiae is modified by methylation at both arginine and lysine residues. Rkm2 (ribosomal lysine methyltransferase 2) is responsible for the predominant epsilon-trimethylation at lysine 10 of Rpl12ab [ ]. This entry includes Rkm2 and other SET domain proteins tha...

[]

0

[ "PIRSF" ]

[ "PIRSF027158" ]

[ "Lys_MTase_YDR198C_prd" ]

[ 1002 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

148

[]

0

[ "PUB00073627" ]

[ "17005568" ]

[ "A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10." ]

[ 2006 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1002 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 3, 1, 1 ]

6

true

Family

SET domain methyltransferase

SET_MeTrfase

3

IPR016853

16,853

S-adenosyl-L-methionine binding protein, YMR209C, predicted

S-AdoMet-bd_YMR209C_prd

Family

23

false

This entry represents proteins predicted to function as S-adenosyl-L-methionine binding proteins, such as the uncharacterised protein YMR209C from Saccharomyces cerevisiae (Baker's yeast).

[]

0

[ "PIRSF" ]

[ "PIRSF027174" ]

[ "SAM_bd_YMR209C_prd" ]

[ 23 ]

1

[]

0

[]

0

[]

0

[ "IPR012901" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 23 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

S-adenosyl-L-methionine binding protein, YMR209C, predicted

S-AdoMet-bd_YMR209C_prd

6

IPR016854

16,854

Cell death protein 4

Ced-4

Family

2

false

Ced-4 is a family of apoptosis proteins from nematodes. Caenorhabditis elegans has three genes, ced-3, ced-4 and ced-9, which code for the components of an induction pathway of apoptosis that is conserved in the nematode and mammals. Homologues in have also been found in Drosophila [ ]. Egl-1 binds to and directly inhi...

[]

0

[ "PIRSF" ]

[ "PIRSF027202" ]

[ "Apop_reg_Ced-4" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00017281", "PUB00043497", "PUB00043498", "PUB00043499", "PUB00153724", "PUB00153725", "PUB00153726", "PUB00153727", "PUB00153728", "PUB00153729" ]

[ "11341280", "11042675", "11387322", "11076957", "17329362", "21901106", "22629231", "23106139", "25432023", "26074078" ]

[ "Apoptosis. Death of a monopoly?", "Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila.", "The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.", "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of ...

[ 2001, 2000, 2001, 2001, 2007, 2011, 2012, 2013, 2014, 2015 ]

10

[]

0

null

[ "Caenorhabditis briggsae" ]

[ 2 ]

1

[]

0

true

Family

Cell death protein 4

Ced-4

8

IPR016856

16,856

NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1

QueF_type1

Family

7,588

false

Members of this group are involved in the biosynthesis of queuosine, a 7-deazaguanine-modified nucleoside found in tRNA(GUN) of Bacteria and Eukarya. QueF (YkvM) from Bacillus subtilis has been shown to catalyse the NADPH-dependent reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine, a late step in the ...

[ "GO:0046857", "GO:0008616", "GO:0005737" ]

[ "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "tRNA queuosine(34) biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_00818", "PIRSF027377", "TIGR03139" ]

[ "QueF_type1", "Nitrile_oxidored_QueF", "QueF-II" ]

[ 7535, 5644, 7563 ]

3

[ "EC", "GP", "METACYC" ]

[ "1.7.1.13", "GenProp0677", "PWY-6700" ]

[ "EC:1.7.1.13", "GP:GenProp0677", "METACYC:PWY-6700" ]

3

[ "4f8b", "4fgc", "5udg" ]

3

[ "PUB00022220", "PUB00035931", "PUB00035932", "PUB00035933" ]

[ "12559918", "7063869", "14660578", "15767583" ]

[ "Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.", "Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature.", "Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.", "From cyclohydro...

[ 2003, 1982, 2004, 2005 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 9, 7321, 6, 24, 228 ]

5

[]

0

true

Family

NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1

QueF_type1

6

IPR016857

16,857

Uncharacterised conserved protein UCP027682, CUB, vWA

UCP027682_CUB_vWA

Family

6

false

This group represents an uncharacterised conserved protein with CUB and vWA domain from nematodes.

[]

0

[ "PIRSF" ]

[ "PIRSF027682" ]

[ "UCP027682_CUB_vWA" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 6 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP027682, CUB, vWA

UCP027682_CUB_vWA

1

IPR016858

16,858

N-lysine methyltransferase KMT5A-like

KMT5A-like

Family

1,960

false

This entry includes a group of animal proteins that belong to the class V-like SAM-binding methyltransferase superfamily and contain the SET domain usually flanked by other domains forming the so-called pre- and post-SET regions. The enzymes belonging to this class all N-methylate lysine in proteins. Most of them are h...

[ "GO:0042799" ]

[ "histone H4K20 methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PROFILE" ]

[ "PS51571" ]

[ "SAM_MT43_PR_SET" ]

[ 1960 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.1.1.-", "2.1.1.361", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601...

[ "EC:2.1.1.-", "EC:2.1.1.361", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729"...

172

[ "1zkk", "2bqz", "3f9w", "3f9x", "3f9y", "3f9z", "4ij8", "5hq2", "5t5g", "5teg", "5th7", "5v2n", "5w1y", "6boz", "7d1z", "7d20", "7xpx", "9cr7" ]

18

[ "PUB00007133", "PUB00038920", "PUB00054125", "PUB00057957", "PUB00057958", "PUB00058044", "PUB00058047", "PUB00058048", "PUB00085115" ]

[ "12372294", "15933070", "12826405", "16225687", "21858014", "12121615", "12086618", "15200950", "17327221" ]

[ "Structures of SET domain proteins: protein lysine methyltransferases make their mark.", "Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.", "Many paths to methyltransfer: a chronicle of convergence.", "Natural history of S-adenosylmethionine-binding proteins.", "Comprehens...

[ 2002, 2005, 2003, 2005, 2011, 2002, 2002, 2004, 2007 ]

9

[]

0

null

[ "Metazoa" ]

[ 1960 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 3, 5, 10 ]

6

true

Family

N-lysine methyltransferase KMT5A-like

KMT5A-like

1

IPR016859

16,859

Uncharacterised conserved protein UCP207779

UCP207779

Family

52

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF027779" ]

[ "UCP207779" ]

[ 52 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 52 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP207779

UCP207779

3

IPR016860

16,860

Cerberus

Family

970

false

This entry represents the cerberus family of proteins. Cerberus is a cytokine that may play a role in anterior neural induction and somite formation during embryogenesis, in part through a BMP-inhibitory mechanism [ ]. It can regulate Nodal signalling during gastrulation as well as the formation and patterning of the p...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF027807", "PTHR15273" ]

[ "Cerberus", "" ]

[ 780, 970 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-201451", "R-HSA-1181150", "R-HSA-1433617", "R-HSA-201451", "R-HSA-9937080", "R-MMU-201451", "R-XTR-201451" ]

[ "REACTOME:R-GGA-201451", "REACTOME:R-HSA-1181150", "REACTOME:R-HSA-1433617", "REACTOME:R-HSA-201451", "REACTOME:R-HSA-9937080", "REACTOME:R-MMU-201451", "REACTOME:R-XTR-201451" ]

7

[]

0

[ "PUB00042732" ]

[ "12431380" ]

[ "Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks." ]

[ 2002 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 970 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 4, 2 ]

4

true

Family

Cerberus

2

IPR016862

16,862

Uncharacterised conserved protein UCP027936

UCP027936

Family

22

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF027936" ]

[ "UCP027936" ]

[ 22 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spirochaetales" ]

[ 22 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP027936

UCP027936

7

IPR016863

16,863

dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

DesII

Family

52

false

DesII is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily involved in the biosynthesis of TDP-D-desosamine. D-Desosamine is found in a number of macrolide antibiotics produced by Streptomyces venezuelae [ ]. DesII catalyses the deamination of TDP-4-amino-4,6-dideoxy-d-glucose to form TDP-3-keto-...

[ "GO:0016841", "GO:0051539", "GO:0033068" ]

[ "ammonia-lyase activity", "4 iron, 4 sulfur cluster binding", "macrolide biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "SFLD", "NCBIFAM" ]

[ "PIRSF027982", "SFLDF00425", "TIGR04426" ]

[ "Reductase_EryCV_prd", "dTDP-4-amino-4_6-dideoxy-D-glu", "rSAM_desII" ]

[ 25, 49, 52 ]

3

[]

0

[ "8hzv", "8hzy" ]

2

[ "PUB00074641", "PUB00074642", "PUB00074643", "PUB00074644" ]

[ "19746907", "20121093", "21513273", "25826575" ]

[ "Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.", "Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII.", "Mechanistic studies of the radica...

[ 2009, 2010, 2011, 2015 ]

4

[]

0

null

[ "Bacteria" ]

[ 52 ]

1

[]

0

true

Family

dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

DesII

3

IPR016864

16,864

Uncharacterised conserved protein UCP028035

UCP028035

Family

370

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028035" ]

[ "UCP028035" ]

[ 370 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dikarya" ]

[ 370 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Family

Uncharacterised conserved protein UCP028035

UCP028035

1

IPR016865

16,865

Inner membrane protein RclC

RclC

Family

2,084

false

This entry includes inner membrane protein RclC which is a reactive chlorine-specific transcription factor in Escherichia coli . Oxidation of cysteine residues leads to activation of genes required for the response to reactive chlorine species [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF028065" ]

[ "UCP028065" ]

[ 2084 ]

1

[]

0

[]

0

[ "PUB00085116" ]

[ "24078635" ]

[ "The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli." ]

[ 2013 ]

1

[ "IPR007339" ]

[]

1

0

1

[ "Bacteria", "Tilletia caries", "bioreactor metagenome" ]

[ 2082, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein RclC

RclC

1

IPR016866

16,866

Uncharacterised conserved protein UCP028069

UCP028069

Family

2,468

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are found in an operon along with components of a TonB transport system (typified by Vibrio cholerae TonB2 [ ], and are predicted to be localized to the periplasm...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF11932", "PIRSF028069" ]

[ "DUF3450", "UCP028069" ]

[ 2468, 1842 ]

2

[]

0

[]

0

[ "PUB00035942" ]

[ "9781885" ]

[ "Vibrio cholerae iron transport: haem transport genes are linked to one of two sets of tonB, exbB, exbD genes." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2410, 6, 52 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP028069

UCP028069

3

IPR016867

16,867

Glycine cleavage system transcriptional repressor

GcvR

Family

5,677

false

Glycine cleavage system transcriptional repressor GcvR acts as a negative transcriptional regulator of the glycine cleavage system operon (GCV) [ ].

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF028103" ]

[ "GcvR" ]

[ 5677 ]

1

[]

0

[ "1u8s" ]

1

[ "PUB00078063" ]

[ "9537378" ]

[ "Promoter characterization and constitutive expression of the Escherichia coli gcvR gene." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 5597, 26, 54 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glycine cleavage system transcriptional repressor

GcvR

1

IPR016869

16,869

Uncharacterised conserved protein UCP028135, HipA-like

UCP028135_HipA-like

Family

826

false

This group represents an uncharacterised protein with HipA-like domain.

[]

0

[ "PIRSF" ]

[ "PIRSF028135" ]

[ "UCP028135_HipA-like" ]

[ 826 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 824, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028135, HipA-like

UCP028135_HipA-like

8

IPR016870

16,870

Uncharacterised conserved protein UCP028137, membrane

UCP028137

Family

820

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PIRSF" ]

[ "PIRSF028137" ]

[ "UCP028137" ]

[ 820 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 810, 10 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028137, membrane

UCP028137

1

IPR016871

16,871

MSHA biogenesis protein, MshI

MSHA_biogenesis_MshI

Family

274

false

This group represents a MSHA biogenesis protein, MshI type.

[]

0

[ "PIRSF" ]

[ "PIRSF028153" ]

[ "MSHA_biogenesis_protein_MshI" ]

[ 274 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 274 ]

1

[]

0

true

Family

MSHA biogenesis protein, MshI

MSHA_biogenesis_MshI

3

IPR016872

16,872

Uncharacterised conserved protein UCP028160

UCP028160

Family

334

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they possess a predicted signal peptide.

[]

0

[ "PIRSF" ]

[ "PIRSF028160" ]

[ "UCP028160" ]

[ 334 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 334 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028160

UCP028160

3

IPR016873

16,873

Capsular polysaccharide biosynthesis protein, BcbE, predicted

Caps_polysacc_synth_BcbE_prd

Family

1,175

false

This group represents a predicted capsular polysaccharide biosynthesis protein known as BcbE.

[]

0

[ "PIRSF" ]

[ "PIRSF028162" ]

[ "BcbE_prd" ]

[ 1175 ]

1

[]

0

[ "4evw" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 12, 1146, 2, 15 ]

4

[]

0

true

Family

Capsular polysaccharide biosynthesis protein, BcbE, predicted

Caps_polysacc_synth_BcbE_prd

5

IPR016874

16,874

Methyltransferase TcmP-like

TcmP-like

Family

4,178

false

This entry represents the enzyme tetracenomycin polyketide synthesis O-methyltransferase TcmP and related proteins. TcmP catalyses the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2, which is then further processed to produce the antibiotic TCM C [ ]. This entry also includes DpfgK fro...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF028177" ]

[ "Polyketide_synth_Omtfrase_TcmP" ]

[ 4178 ]

1

[]

0

[]

0

[ "PUB00070804", "PUB00095619" ]

[ "11009387", "32286350" ]

[ "Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.", "Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones." ]

[ 2000, 2020 ]

2

[ "IPR007213" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Inoviridae sp. ctsTh7", "metagenomes" ]

[ 48, 3915, 201, 1, 13 ]

5

[]

0

true

Family

Methyltransferase TcmP-like

TcmP-like

6

IPR016875

16,875

Uncharacterised conserved protein UCP028200

UCP028200

Family

1,773

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, several members are predicted to have a membrane lipoprotein lipid attachment site. In addition, there are several stringently conserved glutamine residues.

[]

0

[ "PIRSF" ]

[ "PIRSF028200" ]

[ "UCP028200" ]

[ 1773 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1764, 9 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028200

UCP028200

8

IPR016876

16,876

Uncharacterised conserved protein UCP028234

UCP028234

Family

398

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028234" ]

[ "UCP028234" ]

[ 398 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 395, 3 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028234

UCP028234

4

IPR016877

16,877

Uncharacterised conserved protein UCP028235

UCP028235

Family

1,091

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028235" ]

[ "UCP028235" ]

[ 1091 ]

1

[]

0

[ "7d62" ]

1

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1085, 6 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028235

UCP028235

4

IPR016878

16,878

Metal-independent carbonic anhydrase-like

MICAH-like

Family

659

false

This entry represents Metal-independent carbonic anhydrase from Nostoc sp. (MICAH, also known as all2909) and similar prokaryotic proteins. all2909 catalyses the hydration of carbon dioxide (CO2) to bicarbonate (HCO3-). It may function even in metal-poor environments [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF028288" ]

[ "UCP028288" ]

[ 659 ]

1

[]

0

[ "7c5v", "7c5w" ]

2

[ "PUB00151529" ]

[ "34006275" ]

[ "Characterization of a novel type of carbonic anhydrase that acts without metal cofactors." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 603, 50, 6 ]

3

[]

0

true

Family

Metal-independent carbonic anhydrase-like

MICAH-like

3

IPR016879

16,879

Uncharacterised conserved protein UCP028299

UCP028299

Family

290

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028299" ]

[ "UCP028299" ]

[ 290 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammaproteobacteria", "marine metagenome" ]

[ 289, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028299

UCP028299

6

IPR016880

16,880

ABC-type oligopeptide transport system, solute-binding component, Mycoplasmataceae, predicted

ABC_oligopep_solut-bd_myco_prd

Family

132

false

This group represents a predicted ABC-type oligopeptide transport system, solute-binding component, Mycoplasmataceae type.

[]

0

[ "PIRSF" ]

[ "PIRSF028335" ]

[ "ABC_oligopep_OppA_prd" ]

[ 132 ]

1

[]

0

[]

0

[]

0

[ "IPR039424" ]

[]

1

0

1

[ "Mycoplasmatota" ]

[ 132 ]

1

[]

0

true

Family

ABC-type oligopeptide transport system, solute-binding component, Mycoplasmataceae, predicted

ABC_oligopep_solut-bd_myco_prd

5

IPR016881

16,881

Uncharacterised conserved protein UCP028340

UCP028340

Family

25

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. They are closely related to the N-terminal portion of a KpnI-like type III restriction-modification system methyltransferase in Mycoplasmas ( ). However, they lack the conserve...

[]

0

[ "PIRSF" ]

[ "PIRSF028340" ]

[ "UCP028340" ]

[ 25 ]

1

[]

0

[]

0

[ "PUB00035943" ]

[ "7473738" ]

[ "Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes." ]

[ 1995 ]

1

[]

0

null

[ "Mycoplasmoidales" ]

[ 25 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028340

UCP028340

4

IPR016882

16,882

Nucleoside triphosphate/diphosphate phosphatase

SA1684

Family

2,407

false

This entry represents Nucleoside triphosphate/diphosphate phosphatase from Staphylococcus aureus (SA1684, ) and similar sequences predominantly found in firmicutes. This protein, which shows nucleoside phosphatase activity towards nucleoside triphosphates and nucleoside diphosphates, has a significant effect on the pro...

[]

0

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01568", "NF010183", "PIRSF028345" ]

[ "Ntdp", "PRK13662.1", "UCP028345" ]

[ 1761, 2255, 2403 ]

3

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.15", "3.6.1.6", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:3.6.1.15", "EC:3.6.1.6", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

7

[ "7d8g", "7d8i", "7d8l", "7d8q" ]

4

[ "PUB00009885", "PUB00035944", "PUB00100531" ]

[ "7500951", "12614195", "33955674" ]

[ "Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.", "Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus.", "The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity o...

[ 1995, 2003, 2021 ]

3

[ "IPR050212" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2402, 5 ]

2

[]

0

true

Family

Nucleoside triphosphate/diphosphate phosphatase

SA1684

6

IPR016883

16,883

Uncharacterised conserved protein UCP028431

UCP028431

Family

3,210

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia. This entry represents a family of proteins from bacteria whose function is unknown. Most members contain the domain , conserved in glyco...

[]

0

[ "PIRSF" ]

[ "PIRSF028431" ]

[ "UCP028431" ]

[ 3210 ]

1

[]

0

[ "3eu8", "4gl3", "4qt9", "5gzh", "5gzk", "8xul" ]

6

[]

0

[]

0

null

[ "Bacteria", "Knufia peltigerae", "metagenomes" ]

[ 3190, 1, 19 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP028431

UCP028431

9

IPR016884

16,884

Uncharacterised conserved protein UCP028438

UCP028438

Family

127

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028438" ]

[ "UCP028438" ]

[ 127 ]

1

[]

0

[]

0

[]

0

[ "IPR060691" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 127 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028438

UCP028438

5

IPR016885

16,885

Uncharacterised conserved protein UCP028445

UCP028445

Family

52

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF028445" ]

[ "UCP028445" ]

[ 52 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Lysobacteraceae" ]

[ 52 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028445

UCP028445

5

IPR016886

16,886

Predicted glycerophosphotransferase UCP028458

UCP028458_glyceroPtfrase

Family

726

false

This group represents an uncharacterised protein with glycerophosphotransferase domain.

[]

0

[ "PIRSF" ]

[ "PIRSF028458" ]

[ "UCP028458_glyceroPtfrase" ]

[ 726 ]

1

[]

0

[]

0

[]

0

[ "IPR007554" ]

[]

1

0

1

[ "Bacteria", "Knufia peltigerae", "ecological metagenomes" ]

[ 716, 1, 9 ]

3

[]

0

true

Family

Predicted glycerophosphotransferase UCP028458

UCP028458_glyceroPtfrase

5

IPR016887

16,887

Uncharacterised conserved protein UCP028470, steroid isomerase-related

UCP028470_steroid_isom-rel

Family

1,255

false

There is currently no experimental data for members of this family or their homologues. However they appear to be related to steroid isomerases.

[]

0

[ "PIRSF" ]

[ "PIRSF028470" ]

[ "UCP028470" ]

[ 1255 ]

1

[]

0

[ "3h51" ]

1

[]

0

[ "IPR011944" ]

[]

1

0

1

[ "Bacteria", "Chlamydomonas chlamydogama", "ecological metagenomes" ]

[ 1252, 1, 2 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP028470, steroid isomerase-related

UCP028470_steroid_isom-rel

1

IPR016888

16,888

Uncharacterised conserved protein UCP028498

UCP028498

Family

1,543

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10012", "PIRSF028498" ]

[ "DUF2255", "UCP028498" ]

[ 1543, 346 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 13, 1527, 3 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP028498

UCP028498

9

IPR016889

16,889

Uncharacterised conserved protein UCP028503

UCP028503

Family

170

false

This entry represents a group of uncharacterised proteins. There is currently no experimental data for any of the members of this group.

[]

0

[ "PIRSF" ]

[ "PIRSF028503" ]

[ "UCP028503" ]

[ 170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Pseudomonadota" ]

[ 8, 162 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028503

UCP028503

4

IPR016890

16,890

Uncharacterised conserved protein UCP028520

UCP028520

Family

994

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028520" ]

[ "UCP028520" ]

[ 994 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Dikarya", "ecological metagenomes" ]

[ 953, 2, 9, 30 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP028520

UCP028520

4

IPR016891

16,891

Protein of unknown function DUF2321

DUF2321

Family

184

false

Members of this family of hypothetical proteins have no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10083", "PIRSF028570" ]

[ "DUF2321", "UCP028570" ]

[ 184, 36 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "Opisthokonta", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 158, 16, 3, 5, 2 ]

5

[]

0

true

Family

Protein of unknown function DUF2321

DUF2321

2

IPR016892

16,892

Uncharacterised conserved protein UCP028583

UCP028583

Family

103

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27729", "PIRSF028583" ]

[ "UCP028583", "UCP028583" ]

[ 103, 20 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 103 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028583

UCP028583

4

IPR016893

16,893

Protein of unknown function UCP028589

UCP028589

Family

543

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028589" ]

[ "UCP028589" ]

[ 543 ]

1

[]

0

[ "8rk3", "8rk8", "8rqe" ]

3

[]

0

[]

0

null

[ "Bacteria", "Capitella teleta", "Viruses", "metagenomes" ]

[ 487, 1, 49, 6 ]

4

[]

0

true

Family

Protein of unknown function UCP028589

UCP028589

2

IPR016894

16,894

Uncharacterised conserved protein UCP028609

UCP028609

Family

2

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028609" ]

[ "UCP028609" ]

[ 2 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Xylella fastidiosa" ]

[ 2 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028609

UCP028609

4

IPR016895

16,895

Uncharacterised conserved protein UCP028680

UCP028680

Family

232

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028680" ]

[ "UCP028680" ]

[ 232 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 232 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028680

UCP028680

3

IPR016896

16,896

Protein of unknown function DUF2860

DUF2860

Family

823

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF11059", "PIRSF028696" ]

[ "DUF2860", "UCP028696" ]

[ 823, 768 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Potamilus streckersoni", "metagenomes" ]

[ 817, 2, 4 ]

3

[]

0

true

Family

Protein of unknown function DUF2860

DUF2860

1

IPR016897

16,897

S-phase kinase-associated protein 1

SKP1

Family

14,609

false

This entry includes SKP1 from yeasts, animals and plants.

[ "GO:0006511" ]

[ "ubiquitin-dependent protein catabolic process" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF028729", "PTHR11165" ]

[ "E3_ubiquit_lig_SCF_Skp", "" ]

[ 9824, 14609 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-174113", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2565942", "R-BTA-2871837", "R-BTA-5607761", "R-BTA-5607764", "R-BTA-5610780", "R-BTA-5610785", "R-BTA-5676590", "R-BTA-5684264", "R-BTA-68949", "R-BTA-69231", "R-BTA-69601", "R-BTA-8854050", "R-...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-174113", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2565942", "REACTOME:R-BTA-2871837", "REACTOME:R-BTA-5607761", "REACTOME:R-BTA-5607764", "REACTOME:R-BTA-5610780", "REACTOME:R-BTA-5610785", "REACTOME:R-...

156

[ "1fqv", "1fs1", "1fs2", "1ldk", "1nex", "1p22", "2ass", "2ast", "2e31", "2e32", "2ovp", "2ovq", "2ovr", "2p1m", "2p1n", "2p1o", "2p1p", "2p1q", "3c6n", "3c6o", "3c6p", "3l2o", "3mks", "3ogk", "3ogl", "3ogm", "3v7d", "3wso", "4i6j", "5an3", "5hyw", "5hzg"...

112

[ "PUB00006069", "PUB00006070", "PUB00058708", "PUB00067735", "PUB00076424", "PUB00076425", "PUB00076426", "PUB00076427", "PUB00076428" ]

[ "8670864", "7852383", "20181953", "11283612", "25460509", "26320228", "10528262", "12970487", "23226441" ]

[ "The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution.", "Characterization of FP21, a cytosolic glycoprotein from Dictyostelium.", "Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.", "Skp1 form...

[ 1996, 1995, 2010, 2001, 2015, 2015, 1999, 2003, 2012 ]

9

[ "IPR001232" ]

[]

1

0

1

[ "Eukaryota", "Viruses", "unclassified sequences" ]

[ 14572, 29, 8 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 67, 23, 1, 20, 8, 4, 1, 66, 4, 1, 1, 97 ]

12

true

Family

S-phase kinase-associated protein 1

SKP1

7